Please read the Fall 2006 syllabus --it contains answers to most initial questions.

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Textbook used is "Handbook of the Biology of Aging, 5th Ed.", Edited by Edward J. Masuro, Steven N. Austad

Final: 8:00 AM Monday Dec. 11, in 245 CB (the normal classroom)

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Aging in the news: Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16^INK4a Pdf, Nature, News and Views summary

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Reading assigned:
Handbook of the Biology of Aging, Ch 1.
Why We Age Ch 2 and Ch 3. (pdf)
Handbook of the Biology of Aging, Ch 12: Immune System Activity.
Laboratory Evolution of Postponed Senescence in Drosophila. MR Rose. Evolution. v38; 1004-10
Genetic alterations in accelerated ageing syndromes Do they play a role in natural ageing? Monika Puzianowska-Kuznicka. Jacek Kuznicki. 2005. IJBCB, 37; 947-60.
Handbook of the Biology of Aging, Ch 8: Cell Proliferation in Mammalian Aging
Handbook of the Biology of Aging, Ch 3: Protein Structure and Turnover
Handbook of the Biology of Aging, Ch 4: Instability of the Nuclear Genome and the Role of DNA Repair
Handbook of the Biology of Aging, Ch 2: Oxidative Processes in Aging
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Su-Ju Lin, Matt Kaeberlein, Alex A. Andalis, Lori A. Sturtz, Pierre-Antoine Defossez, Valeria C. Culotta, Gerald R. Fink and Leonard Guarente Nature 418, 344-348 (18 July 2002)
This News and Views article summarizes the Lin et al. article, you may want to read it: Longevity: Don't hold your breath. Siu Sylvia Lee and Gary Ruvkun.
Handbook of the Biology of Aging, Ch 5: Alterations of the Mitochondria1 Genome
Handbook of the Biology of Aging, Ch 15: Dietary Restriction: An Experimental Approach to the Study of the Biology of Aging
Handbook of the Biology of Aging, Ch 9: Apoptosis and Aging
New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen. Malene Hansen, Ao-Lin Hsu, Andrew Dillin, Cynthia Kenyon. PLoS Genet 1(1): e17. pdf html
Murine Models of Life Span Extension. Quarrie and Riabowol, 2004, SAGE KE
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. PDF HTML
Stem cells, ageing and the quest for immortality PDF HTML
Position Statement on Human Aging PDF