Please read the Fall 2006 syllabus --it contains answers to most initial questions.
Textbook used is "Why We Age: What Science Is Discovering about the Body's Journey through Life" by Steven N. Austad
Reading assignment for Friday 4/24 and 4/26 classes:
Time to Talk SENS: Critiquing the Immutability of Human AgingAubrey D. N. J. de Grey, Bruce N. Ames, Julie K. Andersen, Andrzej Bartke, Judith Campisi, Christopher B. Heward, Roger J. M. McCarter and Gregory Stock, Ann NY Acad Sci.
Position Statement on Human Aging. Olshansky SJ, Hayflick L, and Carnes BA. 2002. J Geron Biol Sci.
Reading assignment for Friday 4/14 class:
New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen. Malene Hansen, Ao-Lin Hsu¤a, Andrew Dillin¤b, Cynthia Kenyon. PLoS. 2005. 1:119-28.
PDF
Reading assignment Wednesday 4/12 class:
Murine Models of Life Span Extension. Quarrie and Riabowol, 2004, SAGE KE
Reading assignment for Friday 4/7 class:
Longevity: Don't hold your breath. Siu Sylvia Lee and Gary Ruvkun.
and
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Su-Ju Lin, Matt Kaeberlein, Alex A. Andalis, Lori A. Sturtz, Pierre-Antoine Defossez, Valeria C. Culotta, Gerald R. Fink and Leonard Guarente Nature 418, 344-348 (18 July 2002)
Reading assignment for Insulin-like pathway lecture (3/6): Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993 Dec 2;366(6454):461-4
Textbook Reading assigned: Ch 1-8, 10.
Exam 2 will be given on March 29.