Baugh et al 2003, subclass E_83min, 413 genes Gene list file name: Baugh2003_classEpi_83min.txt Type of gene identifier: Affymetrix custom chip Description: Baugh et al 2005, Supplymental Dataset, subclass E_425min Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations AC3.7 Aff_AC3.7 dod-15; ugt-1; AC3.7; 5K877; CE05137; NM_073270; WBGene00007072; WP:CE05137 UDP-glucuronosyltransferase Kwon et al 2004 T1 late-induction Ethanol-response, Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T1 xenobiotic induced UDP-gl, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated AFF_C23H3.4 Aff_C23H3.4 AFF_C45E1.4 Aff_C45E1.4 AFF_F20D12.5 Aff_F20D12.5 AFF_F21H12.1 Aff_F21H12.1 AFF_F23F12.2 Aff_F23F12.2 AFF_F28B3.6 Aff_F28B3.6 AFF_F39D8.2 Aff_F39D8.2 AFF_F43C11_37.B Aff_F43C11_37.B AFF_F44B9.8 Aff_F44B9.8 AFF_H24O09.C Aff_H24O09.C AFF_R11D1.9 Aff_R11D1.9 AFF_W09G12.3 Aff_W09G12.3 AFF_Y105E8A.P Aff_Y105E8A.P AFF_Y116A8A.LL Aff_Y116A8A.LL AFF_Y116F11.ZZ17 Aff_Y116F11.ZZ17 AFF_Y25C1A.A Aff_Y25C1A.A AFF_Y45F10A.3 Aff_Y45F10A.3 AFF_Y46B2_176.B Aff_Y46B2_176.B AFF_Y55B1B_119.G Aff_Y55B1B_119.G AFF_Y59A8A.U Aff_Y59A8A.U AFF_Y71A12B.A Aff_Y71A12B.A AFF_Y75B8A.U Aff_Y75B8A.U AFF_Y77E11A_3443.Q Aff_Y77E11A_3443.Q AFF_ZK783.4 Aff_ZK783.4 B0205.6 Aff_B0205.6 B0205.6; 1L315; CE30405; WBGene00015021; WP:CE30405 aminotransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated B0280.8 Aff_B0280.8 nhr-10; B0280.8; 3I202; CE00815; NM_066153; WBGene00003609; WP:CE00815 nhr-10 encodes a predicted nuclear hormone receptor diverged from nuclear hormone receptors in other phyla; its mRNA is expressed throughout development with possibly lower expression from the L4 larval to adult stages, and the protein is expressed in neuronal processes. retinoic acid ViswanathanM et al 2005 S2 sir-2.1 regulated B0303.7 Aff_B0303.7 B0303.7; 3J787; CE36521; WBGene00015128; WP:CE36521 Neutrophil oxidase factor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0336.4 Aff_B0336.4 rgs-5; B0336.4; 3G791; CE32098; NM_065828; WBGene00004348; WBGene00015144; WP:CE32098 rgs-5 encodes a regulator of G protein signaling; by homology, RGS-5 is predicted to function as a GTPase-activating protein that binds G protein alpha subunits and negatively regulates heterotrimeric G protein signaling; loss of rgs-5 activity via RNAi or a deletion mutation results in no obvious defects, and likewise, rgs-5 overexpression has no measurable effect on egg-laying behavior, locomotion, or viability; an rgs-5 transcriptional reporter is expressed in head neurons in larvae and adults. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 B0432.10 Aff_B0432.10 B0432.10; 2A574; CE07748; WBGene00015191; WP:CE07748 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0432.3 Aff_B0432.3 B0432.3; 2A579; CE07741; WBGene00015185; WP:CE07741 ViswanathanM et al 2005 S2 sir-2.1 regulated B0454.9 Aff_B0454.9 B0454.9; 2D344; CE07759; WBGene00015200; WP:CE07759 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma B0491.1 Aff_B0491.1 B0491.1; 2L639; CE02103; WBGene00007189; WP:CE02103 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0547.1 Aff_B0547.1 csn-5; B0547.1; B0547.1.1; B0547.1.2; 4G415; CE06722; NM_068440; WBGene00000817; WP:CE06722 csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C01B12.8 Aff_C01B12.8 C01B12.8; CE07796; NM_061235; WBGene00015291; WP:CE07796 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories C01G10.9 Aff_C01G10.9 C01G10.9; 5P563; CE07818; WBGene00007236; WP:CE07818 Initiation factor 2 subunit McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C01G6.2 Aff_C01G6.2 C01G6.2; 2J557; CE02958; WBGene00007224; WP:CE02958 Reinke et al 2004, herm sperm, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, IVb male soma enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster D, ViswanathanM et al 2005 S2 sir-2.1 regulated C01G6.4 Aff_C01G6.4 C01G6.4; 2J562; CE00866; WBGene00007226; WP:CE00866 Zinc finger, C3HC4 type (RING finger) ViswanathanM et al 2005 S2 sir-2.1 regulated C02B10.4 Aff_C02B10.4 C02B10.4; C02B10.4.1; C02B10.4.2; 4F857; CE16801; WBGene00015329; WP:CE16801 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C03B1.7 Aff_C03B1.7 C03B1.7; CE03909; WBGene00015378; WP:CE03909; XG963 C03D6.4 Aff_C03D6.4 npp-14; C03D6.4; 1K238; CE05198; CeNup214; NM_060167; WBGene00003800; WP:CE05198 npp-14 is orthologous to the human gene NUCLEOPORIN, 214-KD (NUP214; OMIM:114350), which encodes part of the nucleopore complex mediating nucleocytoplasmic transport; NUP214, as a fusion gene with DEK (OMIM:125264), is found in a subset of acute myeloid leukemia. nucleoporin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C04F5.9 Aff_C04F5.9 C04F5.9; 5F594; CE19673; WBGene00015451; WP:CE19673 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C05C8.2 Aff_C05C8.2 C05C8.2; 5H713; CE07920; WBGene00015461; WP:CE07920 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C05D10.1 Aff_C05D10.1 C05D10.1; C05D10.1a.1; C05D10.1a.2; C05D10.1c.1; C05D10.1c.2; C05D10.1c.3; C05D10.1c.4; 3H173; CE24783; CE30420; CE37698; WBGene00015477; WP:CE24783; WP:CE30420; WP:CE37698 ViswanathanM et al 2005 S2 sir-2.1 regulated C05D10.3 Aff_C05D10.3 C05D10.3; 3H174; CE29170; WBGene00015479; WP:CE29170 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C05D11.9 Aff_C05D11.9 C05D11.9; 3H518; CE24787; WBGene00015486; WP:CE24787 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated C05D9.7 Aff_C05D9.7 C05D9.7; CE07933; WBGene00015474; WP:CE07933; XB736 C05E4.9 Aff_H24O09.A gei-7; C05E4.9; C05E4.9a.1; C05E4.9a.2; C05E4.9a.3; C05E4.9b.1; C05E4.9b.2; 5B204; CE23521; CE32565; NM_070905; WBGene00001564; WP:CE23521; WP:CE32565 gei-7 encodes a predicted isocitrate lyase/malate synthase, an enzyme known to function in the glyoxylate cycle; GEI-7 was identified in a screen for proteins that interact with GEX-3, a homolog of human HEM-2 which is required for embryonic development; GEI-7 is required for embryonic morphogenesis and appears to act downstream of DAF-16 to influence lifespan. McCarroll et al 2004 SFig5 conserved w/ yeast, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated C05G5.2 Aff_C05G5.2 C05G5.2; CE05225; WBGene00007348; WP:CE05225; XP367 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol C06A1.5 Aff_C06A1.5 C06A1.5; 2K871; CE02117; WBGene00007355; WP:CE02117 DNA directed RNA polymerase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C06A5.5 Aff_C06A5.5 C06A5.5; 1G558; CE07952; WBGene00015503; WP:CE07952 RNA-binding protein C06G1.4 Aff_C06G1.4 ain-1; C06G1.4; C06G1.4.1; C06G1.4.2; CE03967; WBGene00015547; WP:CE03967; XR231 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C07A12.3 Aff_C07A12.3 nhr-35; C07A12.3; CE30855; CE38483; NM_076378; WBGene00003628; WP:CE30855; WP:CE38483; XF155 zinc finger protein C08A9.6 Aff_C08A9.6 C08A9.6; CE06788; WBGene00015586; WP:CE06788; XR708 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C08B11.7 Aff_C08B11.7 ubh-4; C08B11.7; 2I328; CE36913; NM_063283; WBGene00006724; WP:CE36913 thiolesterase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C09G5.4 Aff_C09G5.4 col-39; C09G5.4; 2K995; CE01484; NM_063908; WBGene00000616; WP:CE01484 col-39 encodes a collagen that is individually dispensable for viability and gross morphology in mass RNAi screens; the amino- and carboxyl-terminal cysteine-rich regions of COL-39 are most closely related to those of COL-8, COL-19, and COL-35. collagen Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C10C5.5 Aff_C10C5.5 C10C5.5; 4K147; CE36099; WBGene00007509; WP:CE36099 aminoacylase-1 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C10E2.4 Aff_C10E2.4 C10E2.4; CE08063; WBGene00015674; WP:CE08063; XR360 C10F3.5 Aff_C10F3.5 pcm-1; C10F3.5; 5G442; CE08070; NM_072150; WBGene00003954; WP:CE08070 L-isoaspartyl/D-aspartyl methyltransferase ViswanathanM et al 2005 S2 sir-2.1 regulated C13C4.4 Aff_C13C4.4 C13C4.4; 5M590; CE20504; WBGene00007548; WP:CE20504 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes C14C10.4 Aff_C14C10.4 C14C10.4; C14C10.4.1; C14C10.4.2; 5N74; CE05283; WBGene00007587; WP:CE05283 Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C14F5.1 Aff_C14F5.1 BCL-2; C14F5.1; CE01780; CE29172; WBGene00015776; WP:CE01780; WP:CE29172; XI573 C15H11.8 Aff_C15H11.8 C15H11.8; 5O904; CE08185; WBGene00007616; WP:CE08185 DNA-directed RNA polymerase I like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C15H9.10 Aff_C15H9.10 C15H9.10; CE06836; WBGene00015804; WP:CE06836; XG730 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated C16A3.3 Aff_C16A3.3 C16A3.3; 3H477; CE27690; NM_065997; WBGene00015808; WP:CE27690 Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C16B8.4 Aff_C16B8.4 C16B8.4; CE30248; WBGene00015824; WP:CE30248; XE590 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B C17G10.1 Aff_C17G10.1 C17G10.1; C17G10.1.1; C17G10.1.2; 2F887; CE01785; WBGene00015915; WP:CE01785 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C18A11.7 Aff_C18A11.7 dim-1; C18A11.7; C18A11.7b.1; C18A11.7b.2; C18A11.7b.3; C18A11.7b.4; CE04038; CE27706; WBGene00001000; WP:CE04038; WP:CE27706; XI670 Link et al 2003 T2 Abeta repressed, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C C18A3.5 Aff_C18A3.5 C18A3.5; C18A3.5e.1; C18A3.5e.2; C18A3.5f.1; C18A3.5f.2; C18A3.5f.3; C18A3.5f.4; C18A3.5f.5; 2G2; CE27708; CE27709; CE27710; CE32130; CE32131; WBGene00015943; WP:CE27708; WP:CE27709; WP:CE27710; WP:CE32130; WP:CE32131 RNA binding protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma C18A3.8 Aff_C18A3.8 hlh-14; C18A3.8; 2G28; CE36629; NM_062730; WBGene00001958; WP:CE36629 hlh-14 encodes a basic helix-loop-helix (bHLH) transcription factor that is one of five C. elegans Achaete-Scute family homologs; HLH-14 activity is required generally for normal egg-laying, movement, body morphology, and larval development; more specifically, HLH-14 is required for proper neuronal development, particularly for regulation of the asymmetric cell division that gives rise to the PVQ/HSN/PHB neuroblasts and for normal differentiation of these neuroblast descendants, including their cell division patterns, migrations, and neurotransmitter expression; in specifying neuronal cell fates, genetic evidence suggests that hlh-14 acts together with hlh-2, which encodes the C. elegans E/Daughterless ortholog; HLH-14 is expresed exclusively in the embryo and detected in the left and right PVQ/HSN/PHB neuroblasts and their descendants, as well as in other cells identified, tentatively, as anterior neuroblasts and posterior neuroblasts such as Caapa. helix-loop-helix transcription factor C18B12.6 Aff_C18B12.6 C18B12.6; CE32590; WBGene00007668; WP:CE32590; XP624 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C18D11.2 Aff_C18D11.2 maa-1; C18D11.2; 3M910; CE18513; NM_067130; WBGene00007680; WP:CE18513 maa-1 encodes a predicted membrane-associated Acyl-CoA binding protein; loss of maa-1 activity via RNAi results in no obvious defects. Acyl CoA binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C18H7.3 Aff_C18H7.3 col-102; C18H7.3; 4B353; CE17428; NM_067556; WBGene00000676; WP:CE17428 cuticular collagen Romagnolo et al 2002 Fig3b Cell Structure, ViswanathanM et al 2005 S2 sir-2.1 regulated C18H9.3 Aff_C18H9.3 C18H9.3; 2G981; CE01803; WBGene00016002; WP:CE01803 C23G10.3 Aff_C23G10.3 rps-3; C23G10.3; C23G10.3.1; C23G10.3.2; 3H297; CE01810; NM_065948; WBGene00004472; WP:CE01810 rps-3 encodes a small ribosomal subunit S3 protein that contains a KH RNA-binding domain and by homology,is predicted to function in protein biosynthesis; in C. elegans, RPS-3 activity is required for embryonic and germline development, as well as the overall health of the animal. Ribosomal protein S3 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C25A1.13 Aff_C25A1.13 C25A1.13; 1K769; CE08379; WBGene00007712; WP:CE08379 NADH-ubiquinone oxidoreductase B8 subunit McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C26E6.6 Aff_C26E6.6 C26E6.6; C26E6.6.1; C26E6.6.2; 3G25; CE39477; WBGene00016142; WP:CE39477 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Ribosomal protein L3 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C27D8.3 Aff_C27D8.3 C27D8.3; 4N472; CE08422; CE39679; WBGene00007779; WP:CE08422; WP:CE39679 The C27D8.3 gene encodes a protein that may be involved in apoptosis. ViswanathanM et al 2005 S2 sir-2.1 regulated C27F2.8 Aff_C27F2.8 C27F2.8; 3G82; CE39000; WBGene00016170; WP:CE39000 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C27H6.4 Aff_C27H6.4 C27H6.4; 5K464; CE08428; CE31322; WBGene00007786; WP:CE08428; WP:CE31322 C29F9.7 Aff_C29F9.7 pat-4; C29F9.7; C29F9.7.1; C29F9.7.2; 3A708; CE19706; NM_064738; WBGene00003931; WP:CE19706 The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes. integrin-linked kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Roy et al 2002 S2 positivecontrol L1 muscle C31H2.4 Aff_C31H2.4 C31H2.4; CE04132; WBGene00016294; WP:CE04132; XF772 C31H2.4 is orthologous to human 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (HPD; OMIM:276710), which when mutated leads to tyrosinemia type III; C31H2.4 is somewhat less similar to human HPD than C. elegans HPD-1 (to which C31H2.4 is paralogous). Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated C32D5.9 Aff_C32D5.9 lgg-1; C32D5.9; C32D5.9.1; C32D5.9.2; 2G636; CE01849; NM_062876; WBGene00002980; WP:CE01849 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C32E8.2 Aff_C32E8.2 rpl-13; C32E8.2; C32E8.2a.1; C32E8.2a.2; C32E8.2a.3; C32E8.2b.1; C32E8.2b.2; 1E357; CE08526; CE33562; WBGene00004425; WP:CE08526; WP:CE33562 rpl-13 encodes a large ribosomal subunit L13 protein. ViswanathanM et al 2005 S2 sir-2.1 regulated C33H5.15 Aff_C33H5.15 sgo-1; C33H5.15; 4I560; CE34732; NM_068889; WBGene00016381; WP:CE34732 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C34E7.4 Aff_C34E7.4 C34E7.4; CE03061; WBGene00007934; WP:CE03061; XN552 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol C34G6.4 Aff_C34G6.4 pgp-2; C34G6.4; 1G471; CE29212; NM_059306; WBGene00003996; WP:CE29212 pgp-2 encodes a member of the ABC transporter family with highest similarity to the vertebrate MDR (multidrug resistance) family, and is orthologous to human MDR1 (ABCB1; OMIM:171050, mutated in Crohn disease); PGP-2 is expressed at lower levels during the embryonic stages with higher expression later in development. abc transporter McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C C34G6.6 Aff_C34G6.6 noah-1; C34G6.6; C34G6.6a.1; C34G6.6a.2; 1G452; CE29699; CE30432; WBGene00016422; WP:CE29699; WP:CE30432 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 C35D10.9 Aff_C35D10.9 ced-4; C35D10.9; 3F943; CE01203; CE38154; WBGene00000418; WP:CE01203; WP:CE38154 ced-4 encodes a novel protein; along with CED-3, CED-4 is required for the initiation of programmed cell death; accordingly, genetic analyses indicate that ced-3 and ced-4 function upstream of ced-1, ced-2, and nuc-1 in the programmed cell death pathway; in yeast two-hybrid experiments, and upon coexpression in mammalian cells, CED-4 interacts with CED-9, an anti-apoptotic BCL-2 homolog; coexpression of CED-4 and CED-9 results in redistribution of CED-4 from the cytosol to organellar membranes, suggesting that CED-9 may negatively regulate CED-4 activity by sequestering CED-4 to intracellular membranes. Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C37A2.5 Aff_F08B6.A pqn-21; C37A2.5; 1H350; CE27748; CE32818; WBGene00004111; WP:CE27748; WP:CE32818 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C37E2.4 Aff_C37E2.4 ceh-36; C37E2.4; CE08623; NM_077964; WBGene00000457; WP:CE08623; XO802 ceh-36 encodes a paired-like homeodomain transcription factor that is one of three orthodenticle (OTD)-like homeodomain proteins in C. elegans (the others being ttx-1 and ceh-37); CEH-36 is required broadly for specification of the AWC olfactory neuron and also for establishing the left-right asymmetry of the ASEL and ASER gustatory neurons; in addition, CEH-36 is sufficient to specify the AFD thermosensory neuron fate in some cell types; CEH-36 is expressed in the AWC and ASE chemosensory neurons. Homeobox domain C39E6.4 Aff_C39E6.3 mls-2; C39E6.4; CE30891; NM_076414; WBGene00003377; WP:CE30891; XF378 C39F7.2 Aff_C39F7.2, Aff_Y50D4A_25.A C39F7.2; C39F7.2.1; C39F7.2.2; 5B704; CE27581; WBGene00016539; WP:CE27581 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C40A11.2 Aff_C40A11.2 C40A11.2; C40A11.2.1; C40A11.2.2; 2C437; CE34742; WBGene00016545; WP:CE34742 C40A11.3 Aff_C40A11.3 C40A11.3; 2C433; CE19366; WBGene00016546; WP:CE19366 Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated C41A3.1 Aff_C41A3.1 C41A3.1; CE04187; WBGene00016558; WP:CE04187; XG59 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. polyketide synthase C41C4.8 Aff_C41C4.8 cdc-48.2; C41C4.8; C41C4.8.1; C41C4.8.2; C41C4.8.3; 2I431; CE05402; NM_063304; WBGene00008053; WP:CE05402 P97 protein Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C41D11.2 Aff_C41D11.2 eif-3.H; C41D11.2; 1F13; CE29220; NM_058969; WBGene00001231; WP:CE29220 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, male germline, Reinke et al 2004, wt males vs glp4 male enriched , Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C41H7.1 Aff_C41H7.1 C41H7.1; 2D307; CE32605; WBGene00016571; WP:CE32605 C43E11.9 Aff_C43E11.9 C43E11.9; C43E11.9.1; C43E11.9.2; 1E836; CE08687; WBGene00016607; WP:CE08687 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C43H8.1 Aff_C43H8.1 C43H8.1; C43H8.1.1; C43H8.1.2; 1L201; CE19377; WBGene00016621; WP:CE19377 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C45B11.1 Aff_C45B11.1 pak-4; tag-66; C45B11.1; 5L518; CE05425; CE20564; WBGene00006443; WP:CE05425; WP:CE20564 P21-Rho-binding domain ; Eukaryotic protein kinase domain Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C45E1.1 Aff_C45E1.1 nhr-64; C45E1.1; 1D677; CE39696; CE39697; WBGene00003654; WP:CE39696; WP:CE39697 nhr-64 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-64 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; however, as loss of nhr-64 activity via RNAi does not result in any obvious abnormalities, the precise role of NHR-64 in C. elegans development and/or behavior is not yet known; nhr-64 is broadly expressed and detected in anterior and posterior neurons, the ventral nerve cord, the pharynx, gut, and hypodermis. Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes in the dauer exit C45E5.6 Aff_C45E5.6 nhr-46; C45E5.6; C45E5.6a.1; C45E5.6a.2; C45E5.6c.1; C45E5.6c.2; C45E5.6c.3; C45E5.6c.4; C45E5.6c.5; C45E5.6c.6; C45E5.6c.7; C45E5.6c.8; 4G512; CE08734; CE29226; CE29227; NM_068457; WBGene00003636; WP:CE08734; WP:CE29226; WP:CE29227 nuclear hormone receptor ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C46C11.2 Aff_C46C11.2 C46C11.2; CE39005; CE39006; WBGene00016705; WP:CE39005; WP:CE39006; XF253 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C46H11.9 Aff_C46H11.9 phat-2; C46H11.9; 1F614; CE08791; WBGene00016733; WP:CE08791 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 C46H3.2 Aff_C46H3.2 C46H3.2; C46H3.2b.1; C46H3.2b.2; CE29228; CE33921; WBGene00016725; WP:CE29228; WP:CE33921; XB832 tyrosine-protein kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C47C12.3 Aff_C47C12.3 C47C12.3; C47C12.3a.1; C47C12.3a.2; CE33037; CE35437; NM_076907; WBGene00004335; WP:CE33037; WP:CE35437; XI361 ref-2 is orthologous to the human gene ZINC FINGER PROTEIN OF CEREBELLUM ZIC2 (ZIC2; OMIM:603073), which when mutated leads to disease. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C47E8.7 Aff_C47E8.7 unc-112; C47E8.7; C47E8.7.1; C47E8.7.2; 5P172; CE05443; NM_074227; WBGene00006836; WP:CE05443 The unc-112 gene encodes a pleckstrin homology domain-containing protein, orthologous to human Mitogen inducible gene-2, that is required for assembly of muscle dense bodies and M lines during embryogenesis; UNC-112 is a dense body/M-line component and requires PAT-3/beta-integrin, UNC-52/perlecan, and PAT-4/integrin-linked kinase for proper localization; UNC-112 binds PAT-4 directly, forms a ternary complex with PAT-4 and PAT-6/actopaxin, and is required for recruitment of PAT-3 and PAT-4 to muscle cell attachment sites; viable unc-112 mutations are suppressed by mutation of dim-1. mitogen inducible MIG-2 protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C C48B6.2 Aff_C48B6.2 C48B6.2; C48B6.2.1; C48B6.2.2; 1H493; CE08804; WBGene00016740; WP:CE08804 ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C48B6.9 Aff_C48B6.9 C48B6.9; 1H502; CE08811; WBGene00016745; WP:CE08811 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C48D1.1 Aff_C48D1.1 C48D1.1; 4N958; CE32833; CE39701; WBGene00008177; WP:CE32833; WP:CE39701 C.elegans ZYG-11 like protein Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes C49C3.15 Aff_C49C3.15 C49C3.15; 4S279; CE37493; WBGene00008204; WP:CE37493 C49C3.8 Aff_C49C3.8 C49C3.8; 4S281; CE19747; WBGene00008198; WP:CE19747 Jones et al 2001 Dauer specific genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit C49H3.6 Aff_C49H3.6 C49H3.6; 4I671; CE29380; CE30506; WBGene00016792; WP:CE29380; WP:CE30506 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C49H3.8 Aff_C49H3.8 C49H3.8; 4I664; CE04234; WBGene00016793; WP:CE04234 actin-like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C50B6.9 Aff_C50B6.9 C50B6.9; 5N819; CE08878; WBGene00008222; WP:CE08878 C52E2.2 Aff_C52E2.H C52E2.2; C52E2.H; 2C125b; CE20597; WBGene00016881; WP:CE20597 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C52E4.2 Aff_C52E4.2 mif-2; C52E4.2; C52E4.2.1; C52E4.2.2; 5M458; CE08944; NM_073602; WBGene00003235; WP:CE08944 macrophage migration inhibitory factor like protein ViswanathanM et al 2005 S2 sir-2.1 regulated C52E4.3 Aff_C52E4.3 snr-4; C52E4.3; C52E4.3.1; C52E4.3.2; 5M460; CE08945; NM_073603; WBGene00004917; WP:CE08945 small nuclear ribonucleoprotein D2 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories C53C11.4 Aff_C53C11.4 C53C11.4; CE04267; WBGene00016901; WP:CE04267; XR923 S. muris microneme antigen C55B6.2 Aff_C55B6.2 dnj-7; C55B6.2; CE09008; NM_076808; WBGene00001025; WP:CE09008; XH815 This gene encodes a protein containing a DnaJ ('J') domain that is predicted to be mitochondrial. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 C56C10.3 Aff_C56C10.3 phi-27; tag-309; C56C10.3; C56C10.3.1; C56C10.3.2; 2G881; CE02568; WBGene00016961; WP:CE02568 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C56G2.15 Aff_C56G2.15 C56G2.15; 3H456; CE01870; WBGene00016983; WP:CE01870 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol D1022.1 Aff_D1022.1 ubc-6; D1022.1; 2H771; CE29241; CE39712; NM_063165; WBGene00006703; WP:CE29241; WP:CE39712 Ubiquitin-conjugating enzyme Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol D1025.2 Aff_D1025.2 D1025.2; CE17610; WBGene00008354; WP:CE17610; XP132 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 D1069.4 Aff_D1069.4 D1069.4; 2A642; CE17616; WBGene00017038; WP:CE17616 D2007.5 Aff_D2007.5 D2007.5; D2007.5.1; D2007.5.2; 3J246; CE00130; WBGene00017045; WP:CE00130 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated D2089.3 Aff_D2089.3 D2089.3; 2K952; CE00938; WBGene00008434; WP:CE00938 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph E03A3.3 Aff_E03A3.3 his-69; E03A3.3; 3F148; CE00942; NM_065410; WBGene00001943; WP:CE00942 his-69 encodes a truncated H3 histone. histone H3 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol E03E2.1 Aff_E03E2.1 cyp-43A1; E03E2.1; E03E2.1.1; E03E2.1.2; CE29747; NM_076560; WBGene00017108; WP:CE29747; XG335 cytochrome P450 ViswanathanM et al 2005 S2 sir-2.1 regulated E04A4.8 Aff_E04A4.8, Aff_Y17G9B.E rpl-20; E04A4.8; E04A4.8.1; E04A4.8.2; 4F516; CE21392; NM_068229; WBGene00004432; WP:CE21392 rpl-20 encodes a large ribosomal subunit L18a protein. ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated EEED8.2 Aff_EEED8.2 EEED8.2; 2F707; CE01886; WBGene00017133; WP:CE01886 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol EEED8.8 Aff_EEED8.8 ndx-6; EEED8.8; 2F680; CE27911; NM_062614; WBGene00003583; WP:CE27911 The ndx-6 gene encodes a NUDIX hydrolase. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F01G10.8 Aff_F01G10.8 daf-14; F01G10.8; 4L19; CE29090; NM_069479; WBGene00000910; WP:CE29090 daf-14 encodes a Smad-related protein that is unusual in that while its C-terminus is well-conserved with Smad proteins, it lacks the N-terminal DNA binding domain found in all other known Smads; DAF-14 is predicted to function as a transducer of the DAF-7/TGF-beta-mediated signal that promotes reproductive growth and negatively regulates dauer formation; as reduction of daf-14 function enhances the dauer constitutive phenotype of daf-8 mutants, and overexpression of daf-14 can rescue daf-8 mutant animals, it is likely that the DAF-14 and DAF-8 Smad proteins function in parallel to control dauer formation; further genetic analyses suggest that DAF-14 and DAF-8 function to antagonize the activities of the DAF-3 Smad and DAF-5 Sno/Ski oncoprotein, which are required for dauer formation; a DAF-14::GFP reporter is expressed in a dynamic pattern in tissues, such as the hypodermis, intestine, and pharynx, that are remodeled during dauer development. Mouse MSMAD protein like Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F02A9.2 Aff_F02A9.2 far-1; F02A9.2; F02A9.2.1; F02A9.2.2; F02A9.2.3; 3K170; CE00133; NM_066609; WBGene00001385; WP:CE00133 far-1 encodes a fatty acid/retinol binding protein; expressed throughout development with highest expression levels in L3 stage larvae and in adult males. O. volvulus 20Kd antigenic peptide Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F02E8.3 Aff_F02E8.3 aps-2; F02E8.3; CE07018; NM_076366; WBGene00000157; WP:CE07018; XF77 The aps-2 gene encodes an adaptin: specifically, it encodes an ortholog of the sigma2 subunit of adaptor protein complex 2 (AP-2), which mediates endocytosis from the plasma membrane; APS-2 appears to be required for embryonic and larval development and for normal body morphology, but is not required for endocytosis of yolk protein in developing oocytes; APS-2 is expressed in nearly all cells during embryogenesis, but during larval and adult stages, expression is confined to neurons and some hypodermal cells, including vulval hypodermal cells during the fourth larval stage. Clathrin coat assembly protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F02E9.7 Aff_F02E9.7 F02E9.7; 1I991; CE09190; WBGene00008531; WP:CE09190 acid phosphatase Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F07A11.2 Aff_F07A11.2 F07A11.2; F07A11.2b.1; F07A11.2b.2; F07A11.2b.3; 2L884; CE03144; CE27915; WBGene00008546; WP:CE03144; WP:CE27915 glucosamine-fructose-6-phosphate aminotransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, IVb male soma enriched genes F07A5.7 Aff_F07A5.7 unc-15; F07A5.7; F07A5.7.1; F07A5.7.2; F07A5.7.3; F07A5.7.4; 1H954; CE09197; NM_059684; WBGene00006754; WP:CE09197 The unc-15 gene encodes a paramyosin ortholog; UNC-15 protein physically interacts with MHC A, one isoform of myosin heavy chain (MHC) in striated muscle; UNC-15 accumulation is decreased in the absence of UNC-54 (myosin B), implying that degradation of UNC-15 is inhibited by its binding myosin B; conversely, myosin B (but not MYO-3/myosin A) fails to accumulate in unc-15 mutants. paramyosin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, IVb male soma enriched genes, Roy et al 2002 S2 positivecontrol L1 muscle, ViswanathanM et al 2005 S2 sir-2.1 regulated F08B12.2 Aff_F08B12.2 prx-12; F08B12.2; CE03163; NM_077507; WBGene00004197; WP:CE03163; XM13 Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F08B6.1 Aff_F08B6.F F08B6.1; F08B6.F; 1H339; CE39717; WBGene00017239; WP:CE39717 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F08C6.6 Aff_F08C6.6 F08C6.6; CE27925; WBGene00017244; WP:CE27925; XI186 Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F08F8.2 Aff_F08F8.2 F08F8.2; 3I451; CE30649; WBGene00017268; WP:CE30649 Hydroxymethylglutaryl-coA reductase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F08G12.1 Aff_F08G12.1 F08G12.1; CE03166; WBGene00008585; WP:CE03166; XL922 ras-related like protein F09E5.3 Aff_F09E5.3 F09E5.3; F09E5.3.1; F09E5.3.2; 2F665; CE02610; WBGene00017283; WP:CE02610 Deoxyribose-phosphate aldolase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F09E5.8 Aff_F09E5.8 F09E5.8; 2F641; CE02615; WBGene00017286; WP:CE02615 Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F10C2.2 Aff_F10C2.2 kup-1; F10C2.2; 5M514; CE09306; NM_073615; WBGene00002241; WP:CE09306; kup1 kup-1 encodes a novel protein that is conserved in C. briggsae, but contains no other known homologs; kup-1 is the upstream gene in an operon with pkc-1, which encodes two protein kinase C isoforms of the nPKC isotype; the polycistronic kup-1/pkc-1 mRNA is detected at low levels in embryos and larvae, but its expression greatly increases in adults; as loss of kup-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kup-1 in C. elegans development and/or behavior is not yet known. KUP-1 protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F10C2.5 Aff_F10C2.5 F10C2.5; CE09309; NM_073617; WBGene00008646; WP:CE09309 mannosyl-oligosaccharide alpha-1,2-mannosidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Romagnolo et al 2002 Fig3b Adhesion F10D7.3 Aff_F10D7.3 F10D7.3; CE29754; WBGene00017340; WP:CE29754; XR988 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. glutaredoxin McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F10E7.1 Aff_F10E7.1 F10E7.1; 2H419; CE39350; WBGene00017343; WP:CE39350 ViswanathanM et al 2005 S2 daf-16 Resveratrol F10E7.7 Aff_F10E7.7 rpl-33; F10E7.7; F10E7.7.1; F10E7.7.2; 2H397; CE04362; NM_063067; WBGene00004447; WP:CE04362 rpl-33 encodes a large ribosomal subunit L35a protein. 60s ribosomal protein L35A McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated F11A3.2 Aff_F11A3.2 F11A3.2; 5J997; CE05586; CE38501; WBGene00008670; WP:CE05586; WP:CE38501 guanine nucleotide exchange factor Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F11E6.3 Aff_F11E6.3 F11E6.3; F11E6.3.1; F11E6.3.2; 4S414; CE19783; WBGene00008707; WP:CE19783 F13D12.2 Aff_F13D12.2 ldh-1; F13D12.2; 2M15; CE02181; LDH; NM_064102; WBGene00002262; WP:CE02181 ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency. L-lactate dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F13D12.4 Aff_F13D12.4 alh-8; F13D12.4; F13D12.4a.1; F13D12.4a.2; F13D12.4a.3; F13D12.4a.4; 2M21; CE02183; CE36262; WBGene00000114; WP:CE02183; WP:CE36262 alh-8 is orthologous to the human gene METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (ALDH6A1; OMIM:603178), which when mutated leads to MMSDH deficiency. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F14F3.2 Aff_F14F3.2 F14F3.2; CE31478; WBGene00008805; WP:CE31478; XL145 ankyrin motif McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F16B4.8 Aff_F16B4.8 cdc-25.2; F16B4.8; 5C63; CE19796; NM_071045; WBGene00000387; WP:CE19796 cdc-25.2 encodes a putative homolog of Cdc25 phosphatase protein family that affects germline proliferation. protein-tyrosine phosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol F16D3.4 Aff_F16D3.4 F16D3.4; 1I940; CE09437; WBGene00008887; WP:CE09437 F16D3.4 encodes an ortholog of human TUBULIN-SPECIFIC CHAPERONE D (TBCD; OMIM:604649), also known as tubulin-folding cofactor D; F16D3.4 may be a ligand and effector of the ARL2 ortholog EVL-20. Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F17C11.8 Aff_F17C11.8 tag-318; F17C11.8; F17C11.8.1; F17C11.8.2; 5L440; CE38502; WBGene00008919; WP:CE38502 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F17E9.10 Aff_F17E9.10 his-32; F17E9.10; 4J99; NM_069006; WBGene00001906 his-32 encodes an H3 histone; by homology, HIS-32 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-32 is a replication-dependent histone locus that resides in the HIS5 cluster on chromosome IV. histone H3 F17H10.1 Aff_F17H10.1 F17H10.1; CE03226; WBGene00008925; WP:CE03226; XN725 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F18C5.3 Aff_F18C5.3 tag-184; F18C5.3; 2G843; CE02652; WBGene00007050; WBGene00017558; WP:CE02652 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F20G4.1 Aff_F20G4.1 F20G4.1; 1I496; CE34296; WBGene00008990; WP:CE34296 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol F22F7.1 Aff_F22F7.1 F22F7.1; F22F7.1a.1; F22F7.1a.2; 5C603; CE17691; CE32871; WBGene00017719; WP:CE17691; WP:CE32871 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F23C8.4 Aff_F23C8.K ubxn-1; F23C8.4; F23C8.K; 1D3; CE20713; WBGene00017733; WP:CE20713 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F25B4.1 Aff_F25B4.1 F25B4.1; F25B4.1.1; F25B4.1.2; 5G193; CE09620; WBGene00017765; WP:CE09620 F25B4.1 is orthologous to the human gene GLYCINE CLEAVAGE SYSTEM T-PROTEIN (AMT; OMIM:238310), which when mutated leads to glycine encephalopathy. aminomethytransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 F25B4.8 Aff_F25B4.8 F25B4.8; 5G170; CE30761; CE30762; WBGene00017771; WP:CE30761; WP:CE30762 ViswanathanM et al 2005 S2 sir-2.1 regulated F25C8.4 Aff_F25C8.4 F25C8.4; 5V375; CE18637; WBGene00009106; WP:CE18637 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. AMP-binding enzymes ViswanathanM et al 2005 S2 sir-2.1 regulated F26F4.3 Aff_F26F4.3 rom-1; F26F4.3; 3F995; CE32392; NM_065628; WBGene00004400; WP:CE32392 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F26G5.9 Aff_F26G5.9 tam-1; F26G5.9; 5F438; CE09704; NM_071934; WBGene00006523; WP:CE09704 tam-1 encodes a broadly expressed nuclear protein with RING finger, B-box, and glutamine/asparagine-rich domains that promotes signalling in the class B synthetic-multivulva gene pathway (which includes the lin-35/RB gene), and also promotes the activity of genes in multicopy transgenic arrays; the normal role of TAM-1's class B activity is presumably to inhibit RAS pathway activity in vulval development, while TAM-1's effect on transgenes may be through changes in the acetylation state of histones in chromatin. Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma F26H9.6 Aff_F26H9.6 CE-RAB5; rab-5; F26H9.6; F26H9.6.1; F26H9.6.2; 1J885; CE09711; NM_060080; WBGene00004268; WP:CE09711 rab-5 encodes a rab related protein of the Ras GTPase superfamily that affects both the localization of P-granules and of PAR-2, and also affects embryonic and larval viability and the cytoplasmic appearance of cells in the early embryo. RAS-related protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories F29C4.7 Aff_F29C4.7 F29C4.7; F29C4.7a.1; F29C4.7a.2; F29C4.7b.1; F29C4.7b.2; 4A876; CE17724; CE31493; CE37226; WBGene00017929; WP:CE17724; WP:CE31493; WP:CE37226 F29C4.7 is orthologous to human RBM15 (OMIM:606077, mutated in infantile acute megakaryoblastic leukemia) and Drosophila NITO; F29C4.7 encodes a paralog of DIN-1; like DIN-1, it has N-terminal RNA recognition motifs (RRMs) and a C-terminal SID/RD (SMRT interaction domain/repressor) domain. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F29F11.1 Aff_F29F11.1 sqv-4; F29F11.1; F29F11.1.1; F29F11.1.2; 5L140; CE05767; NM_073329; WBGene00005022; WP:CE05767 sqv-4 encodes a UDP-glucose 6-dehydrogenase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-4 is orthologous to Drosophila SUGARLESS, human UGDH (OMIM:603370), and zebrafish JEKYLL; SQV-4 is expressed in many cell types, notably oocytes and uterine, seam, pharyngeal, and spermathecal cells, with expression being prominent in 14 of the 22 vulval nuclei of late L4 larvae; the common requirement for SQV-4 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. UDP-glucose dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F30A10.6 Aff_F30A10.6 F30A10.6; 1K67; CE09807; WBGene00009264; WP:CE09807 Yeast recessive suppressor RSD1 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F31C3.1 Aff_F31C3.1 cyn-5; cyp-5; F31C3.1; F31C3.1.1; F31C3.1.2; 1P632; CE17730; NM_061223; WBGene00000881; WP:CE17730 cyp-5 encodes a cyclophilin that is functional in vitro and is predicted to be a secreted protein that is structurally most similar to human cyclophilin B; expressed in the intestine. cyclophillin McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F31C3.5 Aff_F31C3.5 F31C3.5; 1P647; CE17734; WBGene00009287; WP:CE17734 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F32A5.6 Aff_F32A5.6 prx-13; F32A5.6; 2H540; CE28290; NM_063112; WBGene00004198; WP:CE28290 prx-13 is orthologous to the human gene PEX13 (OMIM:601789), which when mutated leads to Zellweger syndrome or neonatal adrenoleukodystrophy. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F32A6.4 Aff_F32A6.4 ags-3.1; ags-3; F32A6.4; CE04472; CE29783; CE34009; NM_171684; NM_171951; WBGene00000092; WP:CE04472; WP:CE29783; WP:CE34009; XF910 ags-3 encodes an ortholog of mammalian AGS3, a receptor independent activator of G protein signalling, and of Drosophila RAPSYNOID; AGS-3 proteins have four GoLoco motifs; AGS-3 is involved in polarity and spindle orientation during early embryogenesis; a region of AGS-3 encompassing three GoLoco motifs specifically binds GOA-1 in yeast two-hybrid assays; AGS-3 is expressed in all muscles, intestine, and weakly in some head and ventral nerve cord neurons, with subcellular localization in strong dots. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F32B6.6 Aff_F32B6.6 msp-77; F32B6.6; 4K659; CE09861; NM_069380; WBGene00003464; WP:CE09861 msp-77 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm F35E12.3 Aff_F35E12.3 F35E12.3; 5O205; CE09918; WBGene00009427; WP:CE09918 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Ser/Thr protein phosphatases Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes F36D4.2 Aff_F36D4.2 F36D4.2; 5J881; CE07190; WBGene00018088; WP:CE07190 synbindin TRS23 family McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F36H2.1 Aff_F36H2.1 tat-5; F36H2.1; 1J812; CE34183; CE34184; CE39367; WBGene00009498; WP:CE34183; WP:CE34184; WP:CE39367 E1-E2 ATPase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F37C12.2 Aff_F37C12.2 F37C12.2; 3I275; CE00741; WBGene00018150; WP:CE00741 Link et al 2003 T2 Abeta induced, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F37H8.1 Aff_F37H8.1 lir-3; F37H8.1; 2L474; CE15994; NM_063994; WBGene00003046; WP:CE15994 lir-3 encodes a lin-26-related protein that shares a unique C2H2 motif together with lir-1, lir-2 and lin-26; contains a region rich in acidic residues suggesting that it may be a transcription factor. Zinc finger, C2H2 type ViswanathanM et al 2005 S2 sir-2.1 regulated F38A6.1 Aff_F38A6.1 Ce-fkh-1; fkh-1; pha-4; F38A6.1; 5V229; CE15998; NM_075605; WBGene00004013; WP:CE15998 Fork head domain, eukaryotic transcription factors Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F39G3.3 Aff_F39G3.3 F39G3.3; 5F211; CE33083; WBGene00018208; WP:CE33083 ViswanathanM et al 2005 S2 sir-2.1 regulated F39H11.3 Aff_F39H11.3 cdk-8; F39H11.3; 1J281; CE32409; NM_059956; WBGene00000409; WP:CE32409 cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development. serine/threonine kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F39H2.4 Aff_F39H2.4 syp-3; F39H2.4; 1J240; CE17814; NM_059944; WBGene00006377; WP:CE17814 Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F40E10.6 Aff_F40E10.6 F40E10.6; F40E10.6.1; F40E10.6.2; F40E10.6.3; CE31508; WBGene00009574; WP:CE31508; XP322 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F40F4.4 Aff_F40F4.4 lbp-3; F40F4.4; CE30130; CE39932; NM_076155; WBGene00002255; WP:CE30130; WP:CE39932; XD877 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, Roy et al 2002 S3 muscle genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F40F9.7 Aff_F40F9.7 F40F9.7; F40F9.7a.1; F40F9.7a.2; F40F9.7b.1; F40F9.7b.2; F40F9.7b.3; F40F9.7b.4; 5K213; CE05856; CE33580; WBGene00009584; WP:CE05856; WP:CE33580 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F41E6.9 Aff_F41E6.9 F41E6.9; 5J86; CE10260; WBGene00018290; WP:CE10260 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F42A9.2 Aff_F42A9.2 lin-49; F42A9.2; 4J389; CE07224; NM_069074; WBGene00003034; WP:CE07224 zinc-finger protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F42G8.11 Aff_F42G8.11 sph-1; F42G8.11; 4I896; CE17070; NM_068959; WBGene00004979; WP:CE17070 sph-1 encodes a member of the synaptophysin/synaptoporin family that contains a MARVEL domain, a membrane-associating domain found in lipid-associating proteins, and contains a transmembrane domain. synaptic vesicle channel protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F42H11.2 Aff_F42H11.2 lem-3; F42H11.2; F42H11.2.1; F42H11.2.2; 1K156; CE10332; NM_060138; WBGene00002276; WP:CE10332 ankyrin domain Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F43G6.1 Aff_F43G6.1 dna-2; F43G6.1; 2M71; CE02219; CE23725; NM_064114; NM_064115; WBGene00001016; WP:CE02219; WP:CE23725 dna-2 encodes the C. elegans ortholog of the yeast and vertebrate Dna2 replication helicases; by homology, DNA-2 is predicted to function as an endonuclease and an ATP-dependent helicase that is involved in DNA replication and repair; in C. elegans, DNA-2 activity is required maternally and zygotically to maintain normal rates of cell division and for proper germ-line, embryonic, and larval development; DNA-2 activity is temperature-sensitive: animals lacking DNA-2 at 16 degrees Celsius (C) are less severely affected than those at 20 or 25 degrees C; in the hermaphrodite gonad, DNA-2 localizes to nuclei of germ cells and developing oocytes, and expression continues in embryos up to the comma stage; DNA-2 then reappears at the L3 larval stage, and in L3 and L4 larvae is visible in the proliferating somatic cells of the uterus and spermatheca. ViswanathanM et al 2005 S2 sir-2.1 regulated F43G6.7 Aff_F43G6.7 F43G6.7; 2M101; CE02225; WBGene00009659; WP:CE02225 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F44D12.5 Aff_F44D12.5 F44D12.5; 4K795; WBGene00009682 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F44E5.4 Aff_F44E5.4 F44E5.4; F44E5.4.1; F44E5.4.2; 2M48; CE18679; WBGene00009691; WP:CE18679 Heat shock hsp70 proteins Custodia et al 2001 T2 heat shock, GuhaThakurta et al 2002 T1 upregu on heat stress, Lund et al 2002 Aging time course Fig2C heatshock, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig2a heat shock, Shen et al 2005 T1 hif-1indepen hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated F44E7.9 Aff_F44E7.9 F44E7.9; 5G271; CE10396; WBGene00018431; WP:CE10396 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F45D11.10 Aff_F45D11_39.B F45D11.10; 2B281; CE23733; WBGene00018456; WP:CE23733 F45E12.5 Aff_F45E12.4 F45E12.5; F45E12.5b.1; F45E12.5b.2; 2H598; CE02741; CE32049; WBGene00018475; WP:CE02741; WP:CE32049 ViswanathanM et al 2005 S2 sir-2.1 regulated F45H11.1 Aff_F45H11.1 F45H11.1; 1K947; CE16055; CE38353; WBGene00009743; WP:CE16055; WP:CE38353 Zinc finger, C2H2 type F46A9.6 Aff_C17E4.11 mec-8; F46A9.6; F46A9.6.1; F46A9.6.2; F46A9.6.3; 1K18; CE08260; NM_060107; WBGene00003172; WP:CE08260 mecanosensory gene mec-8 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F46E10.2 Aff_F46E10.C F46E10.2; F46E10.2.1; F46E10.2.2; F46E10.C; F46E10.H; F46E10.J; 5H1; CE20813; WBGene00018489; WP:CE20813 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Zhang et al 2002, T1 mec-3 dependent genes F46F3.1 Aff_F46F3.1 ceh-27; F46F3.1; 5M140; CE36695; NM_073551; WBGene00000449; WP:CE36695 ceh-27 encodes a homeodomain protein of the NK-2 class that contains Drosophila scarecrow and human NKX-2 (OMIM:606727); CEH-27 activity is essential for embryogenesis and appears to be required for maintaining hypodermal integrity during movement as embryos lacking CEH-27 burst at a breach in the ventral hypodermis upon commencement of muscle contractions; CEH-27 expression is first detected in the ~100-cell embryo in what appear to be MS-derived cells while in later embryos expression is seen in a number of cells in the anterior head region. homeobox protein (NK-2 subfamily) ViswanathanM et al 2005 S2 sir-2.1 regulated F47A4.2 Aff_F47A4.2 dpy-22; mdt-12; psa-6; sop-1; F47A4.2; CE16058; NM_077244; WBGene00001081; WP:CE16058; XK430 dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation; DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression. Reinke et al 2004, wt herm vs wt male enriched gen F47G4.2 Aff_F47G4.2 F47G4.2; 1O670; CE19875; WBGene00009823; WP:CE19875 Leucine Rich Repeat (2 copies) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma F48E8.1 Aff_F48E8.1 lon-1; F48E8.1; 3G567; CE01953; CE29046; CE30996; NM_065765; NM_065766; NM_171866; WBGene00003055; WP:CE01953; WP:CE29046; WP:CE30996 The lon-1 gene encodes a protein belonging to the PR-protein superfamily that is a target of DBL-1 (TGF-beta) signaling, and that regulates polyploidization and body length. ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F49C12.9 Aff_F49C12.9 F49C12.9; 4K80; CE10780; WBGene00009878; WP:CE10780 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F52A8.5 Aff_F52A8.5 F52A8.5; F52A8.5.1; F52A8.5.2; 1H922; CE05912; WBGene00009918; WP:CE05912 F52A8.5 is orthologous to the human gene GLYCINE CLEAVAGE SYSTEM PROTEIN H (GCSH; OMIM:238330), which when mutated leads to glycine encephalopathy. glycine cleavage system H protein like ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F52E4.7 Aff_F52E4.7 F52E4.7; CE10836; WBGene00018703; WP:CE10836; XD714 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F52F12.7 Aff_F52F12.7 F52F12.7; 1K507; CE10852; WBGene00009940; WP:CE10852 F52F12.7 is orthologous to the human gene STEROIDOGENIC ACUTE REGULATORY PROTEIN (STAR; OMIM:600617), which when mutated leads to disease. steroidogenic acute regulatory protein like Kwon et al 2004 T1 late-induction Ethanol-response, ViswanathanM et al 2005 S2 sir-2.1 regulated F52G3.5 Aff_F52G3.5 F52G3.5; CE35720; WBGene00018713; WP:CE35720; XR588 ViswanathanM et al 2005 S2 sir-2.1 regulated F53E10.6 Aff_F53E10.6 F53E10.6; F53E10.6.1; F53E10.6.2; 5D80; CE10930; WBGene00018762; WP:CE10930 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F53G2.1 Aff_F53G2.1 F53G2.1; 2C783; CE10990; WBGene00018766; WP:CE10990 ViswanathanM et al 2005 S2 daf-16 Resveratrol F54A5.1 Aff_F54A5.E F54A5.1; F54A5.1.1; F54A5.1.2; F54A5.E; 1B465; CE20859; WBGene00018786; WP:CE20859 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F54B11.3 Aff_F54B11.3 unc-84; F54B11.3; CE27761; CE28236; WBGene00006816; WP:CE27761; WP:CE28236; XO207 unc-84 encodes a transmembrane protein that contains a SUN domain with homology to S. pombe Sad1 and affects nuclear migration and anchoring of various cell types together with UNC-83 and ANC-1, thereby affecting coordinated locomotion, vulval formation, and egg laying; UNC-84 is localized to the nuclear envelope and requires LMN-1 for this localization, and it is expressed in the nuclear envelope of essentially all adult and embryonic cells. ViswanathanM et al 2005 S2 sir-2.1 regulated F54C9.1 Aff_F54C9.1 iff-2; F54C9.1; F54C9.1.1; F54C9.1.2; F54C9.1.3; 2I850; CE02249; NM_063406; WBGene00002065; WP:CE02249 initiation factor 5A McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F54C9.9 Aff_F54C9.9 F54C9.9; 2I871; CE20865; WBGene00010044; WP:CE20865 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F54F2.2 Aff_F54F2.2 zfp-1; zpf-1; F54F2.2; F54F2.2a.1; F54F2.2a.2; F54F2.2a.3; F54F2.2c.1; F54F2.2c.2; 3J897; CE25003; CE26933; CE33653; WBGene00006975; WP:CE25003; WP:CE26933; WP:CE33653 zfp-1 encodes a leucine zipper, zinc finger, and PHD/LAP domain (plant homeodomain/leukemia-associated protein)-containing protein homologous to human AF10 (OMIM:602409, which is involved in chromosomal translocations associated with acute leukemia); loss of zfp-1 activity via RNA-mediated interference (RNAi) results in suppression of RNAi, suggesting that ZFP-1 plays a role in gene silencing; based on sequence similarity, ZFP-1 is predicted to associate with chromatin. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F55A12.8 Aff_F55A12.8 F55A12.8; F55A12.8.1; F55A12.8.2; F55A12.8.3; 1F918; CE11131; WBGene00018866; WP:CE11131 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes F55A8.1 Aff_F55A8.1 egl-18; elt-5; pvl-3; F55A8.1; F55A8.1.1; F55A8.1.2; F55A8.1.3; 4C681; CE28339; NM_067742; WBGene00001186; WP:CE28339 egl-18 encodes a member of the GATA-family of transcription factors that affects cell migration, cell fate specification; expressed in the head, in hypodermal seam cells, VC neurons, and vulval precursor cells. zinc finger protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F55D12.1 Aff_F55D12.1 F55D12.1; 1I459; CE05955; WBGene00010110; WP:CE05955 Jones et al 2001 Non dauer genes P<0.05 F55F3.1 Aff_F55F3.1 aakb-1; F55F3.1; F55F3.1.1; F55F3.1.2; CE18744; WBGene00010115; WP:CE18744; XO377 Golden et al 2004, N2 vs daf-2 different genes at , Golden et al 2004, N2 vs daf-2 age different gene, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol F55F8.5 Aff_F55F8.5 tag-345; F55F8.5; F55F8.5.1; F55F8.5.2; 1G224; CE11196; WBGene00018893; WP:CE11196 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56A11.3 Aff_F56A11.3 efn-4; mab-26; F56A11.3; 4B319; CE29503; NM_067546; WBGene00001165; WP:CE29503 efn-4 encodes a member of the ephrin family of ligands that affects neuroblast migrations during closure of the ventral gastrulation cleft and subsequent epidermal morphogenesis, possibly functioning independently of EFN-1, EFN-2, EFN-3, and the VAB-1 receptor during morphogenesis; can interact with VAB-1 in vitro, and is expressed in neural and epidermal precursors at the 100-cell stage, in head neurons, pharyngeal cells, lateral and tail neurons, and in the ectoderm during epidermal enclosure. Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order F56C11.6 Aff_F56C11.6 F56C11.6; 1A647; CE17905; CE33402; WBGene00018958; WP:CE17905; WP:CE33402 carboxylesterases McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, list of genes in cluster D, ViswanathanM et al 2005 S2 sir-2.1 regulated F56H1.3 Aff_C04F1.3 F56H1.3; 1G306; CE17914; WBGene00018994; WP:CE17914 Reinke et al 2004, herm sperm, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F57B9.1 Aff_F57B9.1 F57B9.1; 3I53; CE01335; WBGene00018996; WP:CE01335 PNP/PMP oxidase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Shen et al 2005 T1 hif-1 depend hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated F57B9.6 Aff_F57B9.6 inf-1; F57B9.6; F57B9.6a.1; F57B9.6a.2; 3I21; CE01341; CE38524; Ce1F; CeIF; NM_066108; WBGene00002083; WP:CE01341; WP:CE38524 inf-1 encodes a protein with high similarity to eukaryotic initiation factor 4A. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F57C12.5 Aff_F57C12.5 mrp-1; sdf-14; F57C12.5; F57C12.5d.1; F57C12.5d.2; F57C12.5d.3; CE25015; CE29412; CE31189; CE34565; CE39102; NM_075721; WBGene00003407; WP:CE25015; WP:CE29412; WP:CE31189; WP:CE34565; WP:CE39102; XB196 ABC transporter McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F57F4.2 Aff_F57F4.2 F57F4.2; 5G868; CE11340; WBGene00019016; WP:CE11340 Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F58D2.1 Aff_F58D2.1 F58D2.1; 4N951; CE18782; WBGene00010240; WP:CE18782 C.elegans ZYG-11 protein like Romagnolo et al 2002 Fig3b others F58E1.8 Aff_F58E1.8 fbxb-18; F58E1.8; 2B974; CE11386; WBGene00019039; WP:CE11386 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains leucine-rich repeats. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F58G6.1 Aff_F58G6.1 F58G6.1; F58G6.1.1; F58G6.1.2; 4K410; CE03428; WBGene00010272; WP:CE03428 amphiphysin like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F58G6.5 Aff_F58G6.5 nhr-34; F58G6.5; 4K430; CE27764; CE35564; CE35565; NM_069315; NM_171412; WBGene00003627; WP:CE27764; WP:CE35564; WP:CE35565 nhr-34 encodes a member of the nuclear receptor superfamily; phylogenetic analyses indicate that NHR-34 is a divergent nuclear receptor that likely arose from the expansion and diversification of the HNF4 (NR2A) subgroup in C. elegans; the role of NHR-34 in C. elegans development and/or behavior, and the NHR-34 expression pattern, are not yet known. F58H1.5 Aff_F58H1.5 F58H1.5; F58H1.5.1; F58H1.5.2; 5M441; CE06029; WBGene00010288; WP:CE06029 F59D6.1 Aff_F59D6.1 F59D6.1; 5D527; CE11476; WBGene00019103; WP:CE11476 ViswanathanM et al 2005 S2 sir-2.1 regulated H12C20.2 Aff_F38B7.7 pms-2; H12C20.2; 5M48; CE18807; CE19915; NM_073532; NM_073533; WBGene00004064; WP:CE18807; WP:CE19915 DNA mismatch repair protein (PMS2) Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen H12D21.8 Aff_H12D21.8 H12D21.8; 5P385; CE19921; WBGene00010384; WP:CE19921 H20J04.6 Aff_H20J04_717.A H20J04.6; H20J04.B; 2E613; CE20973; WBGene00019221; WP:CE20973 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated H28G03.1 Aff_H28G03.1 H28G03.1; H28G03.1a.1; H28G03.1a.2; H28G03.1c.1; H28G03.1c.2; CE30079; CE30080; CE31190; WBGene00019249; WP:CE30079; WP:CE30080; WP:CE31190; XF837 RNA binding protein ViswanathanM et al 2005 S2 sir-2.1 regulated H32C10.2 Aff_H32C10.B H32C10.2; 4G697; CE21004; WBGene00019256; WP:CE21004 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B K01D12.12 Aff_K01D12.12 cdr-6; K01D12.12; 5M892; CE06051; NM_073712; WBGene00010471; WP:CE06051 glutathione S-transferase ViswanathanM et al 2005 S2 sir-2.1 regulated K01G5.1 Aff_K01G5.1 tag-331; K01G5.1; 3K846; 3L846; CE26718; WBGene00010476; WP:CE26718 Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E K01G5.6 Aff_K01G5.6 rib-2; K01G5.6; 3L835; CE16196; NM_066967; WBGene00004361; WP:CE16196 The rib-2 gene encodes an ortholog of human EXT2, which when mutated leads to hereditary multiple exostoses, type II (OMIM:133701). MULTIPLE EXOSTOSES HOMOLOG 2 Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit K01H12.1 Aff_K01H12.1 K01H12.1; 4K471; CE03453; WBGene00010484; WP:CE03453 K01H12.1 encodes a small protein conserved in diverse eukaryotes, with a CSL motif (a probable zinc finger, sometimes found associated with the N-terminal domain of DnaJ protein); K01H12.1 is probably a small subunit or ancillary protein of RNA polymerase II Elongator or of a hypothetical diphthamide synthase complex; K01H12.1 is orthologous to to mammalian DESR1 (diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1) and S. cerevisiae KTI11; DESR1, and probably KTI11, enables the first step in posttranslational modification of histidine to dipthamide; K01H12.1 has no obvious function in mass RNAi assays. Lund et al 2002 Fig1 aging-regulated genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K02B2.1 Aff_K02B2.1 K02B2.1; 4G707; CE30082; WBGene00019295; WP:CE30082 6-phosphofructo-2-kinase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol K02E10.2 Aff_K02E10.2 hid-1; K02E10.2; CE04694; CE34327; NM_076053; WBGene00001844; WP:CE04694; WP:CE34327; XD111 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph K02G10.1 Aff_K02G10.1 K02G10.1; CE35736; WBGene00019344; WP:CE35736; XF327 ViswanathanM et al 2005 S2 sir-2.1 regulated K07A1.9 Aff_K07A1.9 K07A1.9; 1K188; CE32465; CE32466; CE32467; WBGene00010615; WP:CE32465; WP:CE32466; WP:CE32467 arginyl-tRNA protein transferase like (truncated) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K07B1.7 Aff_K07B1.7 K07B1.7; 5J826; CE29509; CE38846; WBGene00019467; WP:CE29509; WP:CE38846 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K08H10.9 Aff_K08H10.9 K08H10.9; 5K473; CE18881; WBGene00010699; WP:CE18881 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K08H2.6 Aff_K08H2.6 hpl-1; K08H2.6; CE06164; NM_077798; WBGene00001995; WP:CE06164; XN865 The hpl-1 gene encodes a homolog of heterochromatin protein 1 (HP1) that acts to support the activity of HPL-2 in promoting germline function, but that by itself is dispensable for any obvious function in vivo. murine modifier 2 protein like ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K09C4.8 Aff_K09C4.8 sul-1; tag-37; K09C4.8; CE04736; NM_076159; WBGene00006308; WP:CE04736; XD886 sul-1 encodes a member of the sulfatase family. sulfatase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K09E9.3 Aff_K09E9.3 K09E9.3; CE12014; WBGene00010726; WP:CE12014; XQ232 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K10B3.1 Aff_K10B3.1 K10B3.1; CE07364; CE37127; WBGene00019609; WP:CE07364; WP:CE37127; XD755 K10B3.5 Aff_K10B3.5 K10B3.5; CE07368; WBGene00019611; WP:CE07368; XD722 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K10H10.3 Aff_K10H10.3 dhs-8; K10H10.3; 2O785; CE16253; WBGene00000972; WP:CE16253 Alcohol/other dehydrogenases, short chain type ViswanathanM et al 2005 S2 sir-2.1 regulated K11B4.1 Aff_K11B4.1 K11B4.1; K11B4.1.1; K11B4.1.2; 1P387; CE29597; WBGene00010766; WP:CE29597 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA K11G12.5 Aff_K11G12.5 K11G12.5; CE02827; WBGene00019656; WP:CE02827; XH342 mitochondrial 2-oxoglutartae McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K12B6.1 Aff_K12B6.1 K12B6.1; 5G787; CE12164; WBGene00019666; WP:CE12164 M01F1.6 Aff_M01F1.6 M01F1.6; M01F1.6.1; M01F1.6.2; 3E601; CE37982; WBGene00010812; WP:CE37982 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph M03A8.1 Aff_M03A8.1 dhs-28; M03A8.1; CE04770; NM_076745; WBGene00000991; WP:CE04770; XH437 dhs-28 encodes an ortholog of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE 4 (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), which contains a C-terminal SCP-2 sterol transfer domain; the deletion allele dhs-28(ok450) is superficially wild-type. alcohol dehydrogenase; non-specific lipid transfer protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated M03A8.2 Aff_M03A8.2 M03A8.2; CE30679; WBGene00019748; WP:CE30679; XH435 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph M03F4.7 Aff_M03F4.7 M03F4.7; CE12368; CE34060; WBGene00019760; WP:CE12368; WP:CE34060; XF588 calcium binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Zhang et al 2002, T1 mec-3 dependent genes M04B2.4 Aff_M04B2.4 M04B2.4; M04B2.4.1; M04B2.4.2; 4M284; CE12390; WBGene00010847; WP:CE12390 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated M04B2.5 Aff_M04B2.5 M04B2.5; 4M273; CE36554; NM_069769; WBGene00006678; WP:CE36554 potassium channel protein Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated M04F3.4 Aff_M04F3.4 M04F3.4; 1F340; CE12418; WBGene00019770; WP:CE12418 calcium binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph M117.5 Aff_M117.5 fbxb-4; M117.5; 4M595; CE18086; WBGene00010921; WP:CE18086 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 daf-16 Resveratrol M142.8 Aff_M142.5 M142.8; 3M25; CE37540; WBGene00043057; WP:CE37540 R02D3.1 Aff_R02D3.1 R02D3.1; 4B3; CE18095; WBGene00019819; WP:CE18095 The R02D3.1 gene encodes an ortholog of the human gene ALPHA-AMINOADIPATE SEMIALDEHYDE SYNTHASE (AASS; OMIM:605113), which when mutated leads to hyperlysinemia (OMIM:238700). dehydrogenase Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated R04A9.4 Aff_R04A9.4 ife-2; R04A9.4; CE04791; NM_075693; WBGene00002060; WP:CE04791; XB2 The ife-2 gene encodes a member of the Initiation Factor 4E (eIF4E) family. eukaryotic initiation factor 4E (EIF-4E) Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA R04B3.2 Aff_R04B3.2 R04B3.2; CE28745; WBGene00019867; WP:CE28745; XD90 The R04B3.2 gene encodes an ortholog of the human gene LYSOSOMAL GLYCOSYLASPARAGINASE (AGA; OMIM:208400), which when mutated leads to aspartylglucosaminuria (OMIM:208400). glycosylasparaginase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R05D11.6 Aff_R05D11.6 R05D11.6; 1J173; CE32473; WBGene00011034; WP:CE32473 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen R05D3.9 Aff_R05D3.9 R05D3.9; 3J452; CE31049; WBGene00019882; WP:CE31049 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 R05F9.9 Aff_R05F9.9 R05F9.9; 2F190; CE04812; WBGene00019892; WP:CE04812 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R06A4.8 Aff_R06A4.8 R06A4.8; 2O638; CE18115; WBGene00011050; WP:CE18115 R06A4.8 is orthologous to the human gene GLYCOGEN DEBRANCHING ENZYME ISOFORM 6 (AGL; OMIM:232400), which when mutated leads to glycogen storage disease, type III. Alpha amylase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol R07B5.9 Aff_R07B5.8 R07B5.9; CE31575; WBGene00011086; WP:CE31575 R07C3.2 Aff_R07C3.2 R07C3.2; 2B233; CE12524; WBGene00019918; WP:CE12524 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA R07C3.5 Aff_R07C3.5 R07C3.5; 2B217; CE12530; WBGene00019921; WP:CE12530 R08C7.3 Aff_R08C7.3 htz-1; R08C7.3; R08C7.3.1; R08C7.3.2; R08C7.3.3; 4F211; CE07426; WBGene00019947; WP:CE07426 histone H2A variant McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated R08D7.2 Aff_R08D7.2 R08D7.2; 3K59; CE00290; WBGene00011143; WP:CE00290 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated R08E5.3 Aff_R08E5.3 R08E5.3; R08E5.3.1; R08E5.3.2; 5E251; CE12576; WBGene00019963; WP:CE12576 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R09H10.3 Aff_R09H10.3 R09H10.3; 4L369; CE34083; WBGene00011181; WP:CE34083 R09H10.3 is orthologous to the human gene TRANSTHYRETIN (PREALBUMIN, AMYLOIDOSIS TYPE I) (TTR; OMIM:176300), which when mutated leads to disease. ViswanathanM et al 2005 S2 sir-2.1 regulated R10E11.3 Aff_R10E11.3 R10E11.3; R10E11.3a.1; R10E11.3a.2; 3K867; CE23922; CE23923; WBGene00011216; WP:CE23922; WP:CE23923 Ubiquitin-specifc processing protease Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen R11E3.6 Aff_R11E3.6 eor-1; R11E3.6; R11E3.6.1; R11E3.6.2; R11E3.6.3; 4F558; CE19548; NM_068244; WBGene00001324; WP:CE19548 eor-1 encodes an ortholog of the human BTB/zinc-finger transcription factor PLZF (OMIM:176797), which is is found as a retinoic acid receptor alpha (RARA) fusion in acute promyelocytic leukemia (APL); EOR-1 positively regulates RAS/RAF-mediated signalling during excretory system development, as well as RAS/RAF- and WNT-mediated signalling during P12 fate specification; EOR-1 may function with EOR-2 and Hox genes to control the expression of Ras- and Wnt-responsive genes. zinc-finger protein Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol R12C12.1 Aff_R12C12.1 R12C12.1; R12C12.1a.1; R12C12.1a.2; 2G343; CE02846; CE33434; WBGene00020022; WP:CE02846; WP:CE33434 R12C12.1 is orthologous to human GLYCINE DECARBOXYLASE (GLDC; OMIM:238300), which when mutated leads to glycine encephalopathy. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 R12E2.12 Aff_R12E2.12 R12E2.12; 1E742; CE33159; WBGene00020037; WP:CE33159 ViswanathanM et al 2005 S2 sir-2.1 regulated R13G10.2 Aff_R13G10.2 amx-1; R13G10.2; 3E915; CE25088; NM_065371; WBGene00000137; WP:CE25088 monoamine oxidase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R13H4.4 Aff_R13H4.4 hmp-1; R13H4.4; 5M331; CE25089; NM_073584; WBGene00001978; WP:CE25089 alpha-catenin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen T01B11.2 Aff_T01B11.2 T01B11.2; 4J214; CE12894; CE33686; WBGene00020139; WP:CE12894; WP:CE33686 aminotransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 T01H10.8 Aff_T01H10.8 T01H10.8; CE03607; WBGene00011361; WP:CE03607; XM748 Yeast hypothetical protein YCR32 like Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T02G6.5 Aff_T02G6.5 T02G6.5; 1M411; CE18176; WBGene00011388; WP:CE18176 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T03E6.7 Aff_T03E6.7 cpl-1; T03E6.7; T03E6.7.1; T03E6.7.2; 5R74; CE16333; NM_074798; WBGene00000776; WP:CE16333 cpl-1 encodes a member of the cathepsin L-like cysteine protease family required for embryonic viability and normal growth; expressed in eggshells and throughout early embryos, accumulates in intestinal cells during late embryogenesis, and expressed in the cuticle, gonad, and pharynx later in development. cathepsin-like protease McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched T03F1.3 Aff_T03F1.3 T03F1.3; 1E435; CE13100; WBGene00020185; WP:CE13100 T03F1.3 is orthologous to the human gene PHOSPHOGLYCERETE KINASE 1 (PGK1; OMIM:311800), which when mutated leads to hemolytic anemia and neurologic disturbances. phosphoglycerate kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 T04D1.4 Aff_T04D1.4 tag-192; T04D1.4; 1F262; CE18196; WBGene00007053; WBGene00020213; WP:CE18196 helicase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T05D4.1 Aff_T05D4.1 T05D4.1; T05D4.1.1; T05D4.1.2; 3O652; CE16341; WBGene00011474; WP:CE16341 T05D4.1 is orthologous to the human gene ALDOLASE A, FRUCTOSE-BISPHOSPHATE (ALDOA; OMIM:103850), which when mutated leads to aldolase A deficiency. Fructose-bisphosphate aldolase class-I McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T05E11.3 Aff_T05E11.3 T05E11.3; T05E11.3.1; T05E11.3.2; 4L887; CE06362; WBGene00011480; WP:CE06362 endoplasmin precursor (GRP94) Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated T05F1.1 Aff_T05F1.1 T05F1.1; T05F1.1.1; T05F1.1.2; 1K197; CE13267; WBGene00011488; WP:CE13267 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T07C4.2 Aff_T07C4.2 tbx-8; T07C4.2; 3L437; CE36891; NM_066886; WBGene00006545; WP:CE36891 Brachyury Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes T07C4.6 Aff_T07C4.6 tbx-9; T07C4.6; T07C4.6.1; T07C4.6.2; 3L430; CE36892; NM_066885; WBGene00006546; WP:CE36892 Brachyury Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E T07D3.7 Aff_T07D3.7 alg-2; T07D3.7; TO7D3.7; 2B167; CE13367; CE32063; NM_061436; NM_182192; WBGene00000106; WP:CE13367; WP:CE32063 alg-2 encodes a PAZ and PIWI-domain containing protein that is a member of the highly conserved eukaryotic RDE-1/AGO1/PIWI family of proteins that regulate posttranscriptional gene silencing (PTGS); ALG-2 functions with ALG-1 to control specific developmental timing events by positively regulating expression of small temporal RNAs (stRNAs) encoded by lin-4 and let-7; ALG-2 and ALG-1 are also required for RNAi in the germline, although they are not required for RNAi in the soma. ViswanathanM et al 2005 S2 sir-2.1 regulated T08B2.8 Aff_T08B2.8 T08B2.8; 1G786; CE13433; WBGene00020348; WP:CE13433 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T08D10.2 Aff_T08D10.2 T08D10.2; CE33174; WBGene00011615; WP:CE33174; XM569 T08D10.2 encodes an ortholog of the human histone demethylase LSD1 (KIAA0601), and a paralog of C. elegans SPR-5; similar histone demethylase homologs are found in human, mouse, Drosophila, fission yeast, and Arabidopsis; T08D10.2 is predicted to demethylate histone H3 lysine 4 residues and act as a transcriptional corepressor. corticosteroid-binding protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T08E11.5 Aff_T08E11.5 T08E11.5; 2C113; CE33448; WBGene00020361; WP:CE33448 T10B5.8 Aff_T10B5.8 T10B5.8; 5C323; CE18238; WBGene00020394; WP:CE18238 NADH oxidase Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 T12F5.1 Aff_T12F5.1 T12F5.1; 1E311; CE13595; WBGene00020466; WP:CE13595 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T13F2.3 Aff_T13F2.3 pis-1; T13F2.3; 4K558; CE13623; CE23980; NM_069347; NM_069348; WBGene00004031; WP:CE13623; WP:CE23980 pis-1 encodes an ortholog of mammalian Pax transcription activation domain interacting protein PTIP; PIS-1 has an N-terminal glutamine/asparagine-rich domain and four C-terminal BRCT domains, and is dispensable for obvious functions in mass RNAi assays; mammalian PTIP binds to the activation domain of Pax2 and other Pax proteins, and colocalizes with Pax2 to actively expressed chromatin, and appears to be required for embryonic mitosis (perhaps because of a link between BRCT domains and DNA repair). ViswanathanM et al 2005 S2 sir-2.1 regulated T14G10.5 Aff_T14G10.5 T14G10.5; T14G10.5a.1; T14G10.5a.2; 4K919; CE06451; CE39281; WBGene00011775; WP:CE06451; WP:CE39281 T14G10.5 encodes a gamma subunit of the coatomer (COPI) complex; in mass RNAi assays, T14G10.5 is required for locomotion, fertility, normally rapid growth, and general health. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T16G1.10 Aff_T16G1.10 pqn-68; T16G1.10; 5N431; CE20080; NM_073839; WBGene00004151; WP:CE20080 The protein product of this gene was predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS72 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T17E9.2 Aff_T17E9.2 T17E9.2; T17E9.2c.1; T17E9.2c.2; 3H204; CE01406; CE28669; CE31611; WBGene00020549; WP:CE01406; WP:CE28669; WP:CE31611 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T18H9.6 Aff_T18H9.6 mdt-27; T18H9.6; 5J690; CE04974; NM_072985; WBGene00007023; WP:CE04974 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T19E7.3 Aff_T19E7.3 bec-1; T19E7.3; T19E7.3.1; T19E7.3.2; 4G426; CE27592; NM_068443; WBGene00000247; WP:CE27592 bec-1 encodes a coiled-coil protein that is orthologous to the yeast and mammalian autophagy proteins Apg6/Vps30p/beclin1; bec-1 activity is required for normal dauer morphogenesis and survival of dauer larvae, as well as for adult life span extension of daf-2(e1370) mutants at 15 degrees; in addition, loss of bec-1 activity by large-scale RNAi indicates that BEC-1 is required for normal growth rates, movement, and vulval morphogenesis; by homology, BEC-1 may be part of a Class III phosphatidylinositol 3-kinase complex that plays a role in localizing autophagy proteins to preautophagosomal structures, and overexpression of C. elegans bec-1 in S. cerevisiae APG6/VPS30 mutants can rescue associated autophagy defects; a bec-1::GFP reporter fusion is expressed in the hypodermis, intestine, nervous system, pharynx, and reproductive organs, all tissues that are remodelled during dauer larval development. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 T20B12.3 Aff_T20B12.3 T20B12.3; T20B12.3.1; T20B12.3.2; 3I473; CE01409; WBGene00020601; WP:CE01409 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T20G5.10 Aff_T20G5.10 T20G5.10; 3L300; CE00629; WBGene00011872; WP:CE00629 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T22B7.3 Aff_T22B7.2 T22B7.3; CE31242; WBGene00020672; WP:CE31242; XG273 Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, IVb male soma enriched genes, Romagnolo et al 2002 Fig3b Unkown T23B12.3 Aff_T23B12.3 T23B12.3; 5I947; CE14030; WBGene00020718; WP:CE14030 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated T23C6.1 Aff_T23C6.1 mdt-1.2; T23C6.1; CE07526; NM_078377; WBGene00007011; WP:CE07526; XR767 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T23C6.4 Aff_T23C6.2 T23C6.4; CE07529; WBGene00020726; WP:CE07529; XR762 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order T23D8.1 Aff_T23D8.1 mom-5; T23D8.1; 1K545; CE14048; NM_060234; WBGene00003397; WP:CE14048 Drosophila tissue polarity protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E T23F11.4 Aff_T23F11.4 T23F11.4; 3F754; CE01097; WBGene00011956; WP:CE01097 Zinc finger protein (C2H2 type) ViswanathanM et al 2005 S2 sir-2.1 regulated T23F2.5 Aff_T23F2.5 T23F2.5; CE05000; WBGene00020738; WP:CE05000; XG134 Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated T23F6.4 Aff_T23F6.4 rbd-1; T23F6.4; T23F6.4.1; T23F6.4.2; 4N493; CE18963; NM_070031; WBGene00004315; WP:CE18963 RNA recognition motif. (aka RRM, RBD, or RNP domain) (6 domains) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated T23G4.1 Aff_T23G4.1 tlp-1; T23G4.1; T23G4.1.1; T23G4.1.2; 4O466; CE16453; NM_070246; WBGene00006580; WP:CE16453 The tlp-1 gene encodes a C2H2-type zinc finger of the Sp-1-like protein family, which is required for normal asymmetry in the divisions of the T.p and T.ap cells; such asymmetry, in turn, is required for normal, rounded tail morphology in adult males. ViswanathanM et al 2005 S2 sir-2.1 regulated T24D1.4 Aff_T24D1.4 tag-179; T24D1.4; 1K538; CE14168; WBGene00007043; WBGene00011987; WP:CE14168 Yeast DIE2 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T25B9.8 Aff_T25B9.8 T25B9.8; 4L532; CE32940; WBGene00012014; WP:CE32940 lin-15a like protein Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T25D3.2 Aff_T25D3.2 T25D3.2; 2A446; CE19599; WBGene00020796; WP:CE19599 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated T25G12.4 Aff_T25G12.4 rab-6.2; T25G12.4; CE07541; NM_078389; WBGene00004270; WP:CE07541; XR837 rab-6.2 encodes a small, monomeric Rab GTPase that is most closely related to the Drosophila Rab6 and mammalian Rab6a GTPases; by homology, RAB-6.2 is predicted to function as a membrane-associated GTPase required for intracellular vesicular trafficking and for regulation of endo- and exocytosis; however, as loss of rab-6.2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of RAB-6.2 in C. elegans development and/or behavior is not yet known. ras-related protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T26C11.5 Aff_T26C11.5 ceh-41; T26C11.5; CE05024; NM_075939; WBGene00000462; WP:CE05024; XC466 ceh-41 encodes a a ONECUT class CUT homeobox protein with a single N-terminal OCAM domain; the OCAM domain is a nematode-specific motif conserved between CEH-21, CEH-41, and T02B5.2; ceh-41 is one of three nematode-specific ONECUT genes in a cluster with ceh-21 and ceh-39; ceh-41 has no obvious function in mass RNAi assays. paired-type homeobox protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Romagnolo et al 2002 Fig3b TF, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T26C11.6 Aff_T26C11.6 ceh-21; T26C11.6; CE29823; NM_075940; WBGene00000444; WP:CE29823; XC468 ceh-21 encodes a a ONECUT class CUT homeobox protein with a single N-terminal cut domain and an OCAM domain; the cut domain may be a compact DNA-binding domain composed of alpha helices; the OCAM domain is a nematode-specific motif conserved between CEH-21, CEH-41, and T02B5.2; ceh-21 is one of three nematode-specific ONECUT genes in a cluster with ceh-39 and ceh-41; CEH-21 may be required for muscle formation and differentiation, and is expressed in muscle precursor cells and differentiated gut cells; ceh-21 has no obvious function in mass RNAi assays. homeobox Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated T26G10.1 Aff_T26G10.1 T26G10.1; 3K494; CE00337; WBGene00012059; WP:CE00337 RNA helicase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated T27D12.1 Aff_T27D12.1 T27D12.1; T27D12.1.1; T27D12.1.2; T27D12.1.3; 2M135; CE06516; WBGene00012085; WP:CE06516 sodium/phosphate transporter Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol T27F6.5 Aff_T27F6.5 prs-2; T27F6.5; T27F6.5.1; T27F6.5.2; 1N81; CE16514; NM_060767; WBGene00004190; WP:CE16514 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T28B8.1 Aff_T28B8.1 T28B8.1; T28B8.1.1; T28B8.1.2; 1I711; CE14329; WBGene00012113; WP:CE14329 Reinke et al 2004, IVb male soma enriched genes, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated T28C6.4 Aff_T28C6.4 T28C6.4; 4J588; NM_069125; WBGene00000691 cuticle collagen Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T28F2.2 Aff_T28F2.2 T28F2.2; 1E207; CE31075; WBGene00020901; WP:CE31075 ViswanathanM et al 2005 S2 sir-2.1 regulated W01G7.5 Aff_W01G7.5 lem-2; W01G7.5; 2O355; CE20129; NM_064543; WBGene00002275; WP:CE20129 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes W03D8.2 Aff_W03D8.2 W03D8.2; 1D368; CE18322; WBGene00020985; WP:CE18322 ser/thr protein phosphatase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, fem3 enriched genes W04C9.4 Aff_W04C9.4 W04C9.4; 1A935; CE18335; WBGene00021026; WP:CE18335 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes W04D2.1 Aff_W04D2.1 atn-1; W04D2.1; 5M963; CE06539; CE21256; NM_073726; NM_073727; WBGene00000228; WP:CE06539; WP:CE21256 atn-1 encodes an alpha-actinin homolog. W04D2.5 Aff_W04D2.5 W04D2.5; W04D2.5.1; W04D2.5.2; 5M974; CE06542; WBGene00012244; WP:CE06542 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. mitochondrial ribosomal protein S11 like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated W05H7.3 Aff_W05H7.3 sedl-1; W05H7.3; CE14652; NM_075871; WBGene00021046; WP:CE14652; XC58 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol W05H9.1 Aff_W05H9.1 W05H9.1; W05H9.1.1; W05H9.1.2; CE05036; WBGene00021048; WP:CE05036; XG891 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Zhang et al 2002, T1 mec-3 dependent genes, Zhang et al. 2002, Fig2b overexpressed in mec-3MT W08E3.2 Aff_T04D3.7 W08E3.2; 1N926; CE26028; WBGene00012343; WP:CE26028 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated W09D10.3 Aff_W09D10.3 W09D10.3; 3L797; CE16564; WBGene00012361; WP:CE16564 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ribosomal protein L7/L12 mitochondrial Golden et al 2004, N2 vs daf-2 age different gene, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y105E8B.5 Aff_Y105E8A.K Y105E8B.5; 1P253; CE24099; WBGene00013690; WP:CE24099 The Y105E8B. Y17G7B.12 Aff_Y17G7B.12 Y17G7B.12; 2M315; CE19046; WBGene00012465; WP:CE19046 Exonuclease McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories Y17G7B.7 Aff_Y17G7B.7 tpi-1; Y17G7B.7; Y17G7B.7.1; Y17G7B.7.2; 2M328; CE19040; NM_064162; TPI; WBGene00006601; WP:CE19040 tpi-1 is orthologous to the human gene TRIOSEPHOSPHATE ISOMERASE 1 (TPI1; OMIM:190450), which when mutated leads to disease. Triosephosphate isomerase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y17G9B.8 Aff_Y17G9B.C Y17G9B.8; 4F522; CE34607; WBGene00021205; WP:CE34607 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y23H5A.1 Aff_Y23H5A.1 crs-2; Y23H5A.1; 1D199; CE31095; CE32959; NM_170831; NM_170832; WBGene00000801; WP:CE31095; WP:CE32959 crs-2 encodes a predicted cysteinyl-tRNA synthetase required for fertility. Y34D9A.4 Aff_Y34D9A_151.A spd-1; Y34D9A.4; 1B504; CE37061; NM_058408; WBGene00004952; WBGene00021330; WP:CE37061 spd-1 encodes a homolog of human PRC1, tobacco MAP-65, and S. cerevisiae Ase1p that is required for embryonic viability due to its requirement for mitotic spindle stability during the late stages of cytokinesis; SPD-1 is also required for fertility, gonad development, locomotion, and vulval development. Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y37A1B.5 Aff_Y37A1B.5 Y37A1B.5; 4O819; CE19075; WBGene00012538; WP:CE19075 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination Y37E11AR.6 Aff_Y37E11A_93.A efn-1; vab-2; Y37E11AR.6; 4E526; CE27606; NM_068011; WBGene00006869; WP:CE27606 The vab-2 gene encodes an ephrin molecule related to human ephrin B2 (OMIM:600527); VAB-2, expressed primarily in neuronal cells, is a ligand for the VAB-1 ephrin receptor and plays a role in embryonic cell movements, epidermal morphogenesis during later embryogenesis, and oocyte maturation; VAB-2 synergizes with PTP-3, a LAR-like receptor tyrosine phosphatase, to regulate morphogenesis. Bishop et al 2004 T4 57 vhl-1 depend hif-1 indep, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster B Y37E11B.6 Aff_Y37E11B.6 Y37E11B.6; 4E362; CE19616; WBGene00021378; WP:CE19616 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E Y39A1A.12 Aff_Y39A1A.12 Y39A1A.12; Y39A1A.12.1; Y39A1A.12.2; 3L735; CE19131; WBGene00012650; WP:CE19131 Y39A1A.12 encodes a homolog of origin recognition complex 1, which is also a distant paralog of CDC-6; both Y39A1A.12 and CDC-6 encode homologs of the origin complex which, in yeast, controls the start of DNA replication; whether either Y39A1A.12 or CDC-6 are required for this function in C. elegans, individually or in parallel, is unknown. ATPases associated with various cellular activities (AAA) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E Y39A1A.14 Aff_Y39A1A.14 Y39A1A.14; 3L739; CE19133; WBGene00012652; WP:CE19133 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated Y39A1A.3 Aff_Y39A1A.3 Y39A1A.3; 3L682; CE19121; WBGene00012643; WP:CE19121 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y39A1A.6 Aff_Y39A1A.6 Y39A1A.6; 3L707; CE19125; WBGene00012645; WP:CE19125 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y39G8B.2 Aff_Y39G8B.D Y39G8B.2; 2O264; CE24244; WBGene00012723; WP:CE24244 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Shen et al 2005 T1 hif-1indepen hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated Y40B1B.6 Aff_Y40B1B.6 spr-5; Y40B1B.6; Y40B1B.6.1; Y40B1B.6.2; 1O41; CE20240; NM_060965; WBGene00005010; WP:CE20240 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated Y41C4A.10 Aff_Y41C4A.10 elb-1; Y41C4A.10; 3L686; 3M808; CE20250; NM_067116; WBGene00001235; WP:CE20250 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated Y41D4A.4 Aff_Y41D4A_5905.B Y41D4A.4; Y41D4A.4.1; Y41D4A.4.2; 4C515; CE21847; WBGene00021506; WP:CE21847 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y41D4B.12 Aff_Y41D4A_2615.A Y41D4B.12; CE27623; CE31647; WBGene00021515; WP:CE27623; WP:CE31647 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated Y43F4B.5 Aff_Y43F4B.5 Y43F4B.5; Y43F4B.5a.1; Y43F4B.5a.2; 3O391; CE16630; CE34117; WBGene00012803; WP:CE16630; WP:CE34117 Phosphoglucomutase and phosphomannomutase phosphoserine McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y43F8C.13 Aff_Y116F11.ZZ9 Y43F8C.13; 5U164; CE21911; WBGene00012834; WP:CE21911 Inosine-uridine preferring nucleoside hydrolase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes Y45F10A.6 Aff_Y45F10A.6 Y45F10A.6; 4O242; CE18397; CE19171; WBGene00012868; WP:CE18397; WP:CE19171 Probable rabGAP domains McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y45F10D.10 Aff_Y45F10D.10 Y45F10D.10; 4O550; CE16648; WBGene00012889; WP:CE16648 Jones et al 2001 Dauer specific genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit Y47D3B.9 Aff_Y47D3B.9 Y47D3B.9; 3M554; CE19173; WBGene00012943; WP:CE19173 ViswanathanM et al 2005 S2 daf-16 Resveratrol Y47D7A.8 Aff_Y47D7A_138.D skr-14; Y47D7A.8; 5E900; CE22057; NM_071819; WBGene00004820; WP:CE22057 The skr-14 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-14(RNAi) animals are at least superficially normal. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y48A6B.11 Aff_Y48A6B.11 Y48A6B.11; 3M157; CE24379; CE34514; WBGene00012972; WP:CE24379; WP:CE34514 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order Y48A6B.3 Aff_Y48A6B.3 Y48A6B.3; Y48A6B.3.1; Y48A6B.3.2; 3M97; CE19186; WBGene00012964; WP:CE19186 Ribosomal protein L7Ae McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y48B6A.1 Aff_Y48B6A.A Y48B6A.1; Y48B6A.1.1; Y48B6A.1.2; 2O442; CE22116; WBGene00012978; WP:CE22116 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y48E1A.1 Aff_Y48E1A.1 Y48E1A.1; 2N962; CE22157; CE37860; WBGene00012999; WP:CE22157; WP:CE37860 DNA-directed RNA polymerase I largest subunit McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y48G1A.4 Aff_Y48G1A_54.D Y48G1A.4; 1A803; CE27000; WBGene00021660; WP:CE27000 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y4C6B.1 Aff_Y4C6B.H Y4C6B.1; Y4C6B.H; 4G119; CE21305; WBGene00021155; WP:CE21305 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y52B11A.10 Aff_Y52B11A.10 Y52B11A.10; 1L643; CE20298; WBGene00013129; WP:CE20298 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y53C12B.1 Aff_Y53C12B.1 Y53C12B.1; 2K34; CE14894; WBGene00013143; WP:CE14894 WD domain, G-beta repeats (4 domains) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y54E5A.1 Aff_Y105E8A.AA Y54E5A.1; 1P280; CE28791; WBGene00013197; WP:CE28791 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C Y55F3AR.2 Aff_Y55F3A_750.E Y55F3AR.2; Y55F3A_750.E; 4B849; CE34418; WBGene00021933; WP:CE34418 Y56A3A.18 Aff_Y56A3A.Q Y56A3A.18; Y56A3A.18.1; Y56A3A.18.2; 3N8; CE22586; WBGene00013236; WP:CE22586 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y57A10A.19 Aff_Y57A10A.S Y57A10A.19; 2M517; CE25503; WBGene00013260; WP:CE25503 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order Y58G8A.4 Aff_Y58G8A_208.A Y58G8A.4; 5A756; CE33345; CE36962; WBGene00021983; WP:CE33345; WP:CE36962 Y59C2A.3 Aff_Y59C2A.3 Y59C2A.3; 2C506; CE37171; WBGene00021986; WP:CE37171 Y61A9LA.1 Aff_Y61A9LA_74.D Y61A9LA.1; 5F79; CE29895; WBGene00022014; WP:CE29895 ViswanathanM et al 2005 S2 sir-2.1 regulated Y63D3A.2 Aff_Y63D3A.2 fbxb-100; Y63D3A.2; 1O684; CE20333; WBGene00013403; WP:CE20333 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated Y71F9AL.6 Aff_Y71F9A_262.B Y71F9AL.6; 1D459; CE22840; WBGene00022111; WP:CE22840 Y71F9B.5 Aff_Y71F9B_287.C, Aff_Y71F9B_299.B lin-17; Y71F9B.5; Y71F9B.5b.1; Y71F9B.5b.2; Y71F9B_287.C; 1D285; CE25569; CE28810; NM_058627; WBGene00003006; WP:CE25569; WP:CE28810 lin-17 encodes one of four C. elegans Frizzled homologs, integral membrane proteins that contain an external cysteine rich domain (CRD) and seven transmembrane domains and that function in a wide variety of species as receptors for Wnt glycoprotein signaling molecules; LIN-17 activity is required for specifying the polarity of a number of asymmetric cell divisions that, in C. elegans, are essential for development of such structures as the vulva, somatic gonad, and tail; LIN-17 is also required for the proper polarity of neuronal migrations along the anterior-posterior axis; genetic interactions indicate that LIN-17 likely functions as a receptor for several different Wnt molecules, including LIN-44 and EGL-20, and that in specifying cell fates, the LIN-17-mediated signaling pathway often functions redundantly with other signaling pathways, including the RTK/Ras pathway; a LIN-17 translational reporter fusion shows membrane-associated expression in all of the Pn.pxx vulval precursor cells, in the descendants of V6 and T in males, in the P11.p and B cells, as well as their daughters, and granddaughters, and weakly in P10.p and its daughters; the reporter fusion does not reveal expression in P7.p, Z1, Z4, and T Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y73C8B.4 Aff_Y73C8B.D lag-2; let-461; sel-3; Y73C8B.4; Y73C8B.D; 5D667; CE22970; NM_071476; WBGene00002246; WP:CE22970 lag-2 encodes a transmembrane protein of the Delta/Serrate/Lag-2 (DSL) family that functions as a signaling ligand for the GLP-1 and LIN-12 Notch-like receptors; LAG-2 is required for larval viability and for cell fate decisions involving the germline (meiosis vs mitosis), the somatic gonad, and the early embryo; in addition, LAG-2 functions redundantly with the transmembrane APX-1 and secreted DSL-1 ligands to regulate lateral signaling during vulval development; LAG-2 is expressed in the distal tip cell of the somatic gonad, the ventral nerve cord, the descendants of ABalap and MSap in the developing embryo, and in all six vulval precursor cells (VPCs) during the early L3 stage, with later expression in the VPCs generally restricted to P6.p; lag-2 expression in the vulval cells is regulated by the LET-23/EGF receptor signaling pathway and the SUR-2 component of the Mediator transcription complex. intercellular signal protein ViswanathanM et al 2005 S2 sir-2.1 regulated Y76A2B.3 Aff_Y76A2B.3 Y76A2B.3; 3O630; CE19275; WBGene00013575; WP:CE19275 AMP-binding enzyme Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C Y77E11A.10 Aff_Y77E11A_3443.M clp-6; Y77E11A.10; 4C192; CE25611; NM_067680; WBGene00000546; WP:CE25611 clp-6 encodes a calpain homolog that has significant identity to mammalian calpains over its whole length and that contains motifs typical of calpains, including a thiol (cysteine) protease active site and a Ca[2+]-binding domain; CLP-6 is not required for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf), since clp-6(RNAi) has no effect on such degeneration. Reinke et al 2004, herm sperm, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, GO categories, Reinke et al 2004, fem3 enriched genes Y82E9BR.14 Aff_Y119D3_446.D Y82E9BR.14; Y82E9BR.14a.1; Y82E9BR.14a.2; 3C500; CE27038; CE34433; WBGene00022347; WP:CE27038; WP:CE34433 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y87G2A.2 Aff_Y87G2A.H Y87G2A.2; 1O127; CE28719; WBGene00013594; WP:CE28719 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated Y94H6A.5 Aff_Y94H6A_149.A Y94H6A.5; 4D454; CE37302; CE37303; WBGene00022378; WP:CE37302; WP:CE37303 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph ZC302.2 Aff_ZC302.2 ZC302.2; 5L219; CE06574; WBGene00013862; WP:CE06574 guanine nucleotide binding protein Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC376.5 Aff_ZC376.5 trm-1; ZC376.5; 5O664; CE15201; NM_074112; Trm1; WBGene00006613; WP:CE15201 N2,N2-dimethylguanosine tRNA methyltransferase Jones et al 2001 Non dauer genes P<0.05, Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA ZK1098.5 Aff_ZK1098.5 ZK1098.5; 3K615; CE00368; WBGene00014222; WP:CE00368 ZK1098.5 encodes a unfamiliar protein that is individually dispensable for viability and gross morphology in RNAi assays, but is cotranscribed with ZK1098.1 and thus might act in concert with it. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1127.5 Aff_ZK1127.5 ZK1127.5; 2H339; CE32083; WBGene00022852; WP:CE32083 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Romagnolo et al 2002 Fig3b Metabolism, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1236.3 Aff_ZK1236.3 phi-57; ZK1236.3; 3J511; CE00532; WBGene00023405; WP:CE00532 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK154.3 Aff_ZK154.3 mec-7; ZK154.3; CE15257; NM_076912; WBGene00003171; WP:CE15257; XI394 mec-7 encodes a beta-tubulin required for touch sensitivity along the body wall, and for normal levels of locomotor activity; it is strongly expressed in six touch receptor neurons, with weak expression in FLP, PVD, and BDU cells. beta tubulin Roy et al 2002 S3 muscle genes, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK180.3 Aff_ZK180.3 ZK180.3; ZK180.3b.1; ZK180.3b.2; ZK180.3b.3; 4F274; CE07621; CE33959; WBGene00022677; WP:CE07621; WP:CE33959 Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit ZK185.2 Aff_ZK185.2 ZK185.2; 4F305; CE31747; WBGene00022682; WP:CE31747 ZK265.6 Aff_ZK265.6 ZK265.6; 1I831; CE15299; WBGene00013958; WP:CE15299 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated ZK484.4 Aff_ZK484.4 ZK484.4; 1G648; CE27354; CE27355; WBGene00022750; WP:CE27354; WP:CE27355 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK512.3 Aff_ZK512.3 ced-11; ZK512.3; 3K213; CE00409; NM_066620; WBGene00000425; WP:CE00409 The ced-11 gene encodes a predicted transmembrane ion channel related to the long transient receptor potential channel (LTRPC) subfamily of TRP channels found in Drosophila and mammals; CED-11 functions as a downstream effector in the programmed cell death pathway and may play a role in affecting the morphological changes seen in the nucleus, cytoplasm, and plasma membrane of apoptotic cells. Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK593.1 Aff_ZK593.1 ZK593.1; 4L677; CE24731; WBGene00014001; WP:CE24731 pyruvate kinase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK593.8 Aff_ZK593.8 ZK593.8; 4L703; CE28722; WBGene00014004; WP:CE28722 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK84.1 Aff_ZK84.1 ZK84.1; 2G313; CE02924; WBGene00022649; WP:CE02924 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK858.7 Aff_ZK858.7 ZK858.7; 1J718; CE35204; WBGene00014120; WP:CE35204 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK899.8 Aff_C07B5.1 GAP-2-4; gap-2; ZK899.8; ZK899.8i.1; ZK899.8i.2; CE23470; CE23471; CE23472; CE23473; CE23474; CE23475; CE28277; CE31677; CE39119; NM_077193; WBGene00001516; WP:CE23470; WP:CE23471; WP:CE23472; WP:CE23473; WP:CE23474; WP:CE23475; WP:CE28277; WP:CE31677; WP:CE39119; XK133 gap-2 encodes a Ras GTPase-activating protein (RasGAP) that is orthologous to mammalian nGAP and synGAP (OMIM:606136, OMIM:603384, synGAP is essential for postnatal survival and neuronal development); by homology, GAP-2 is predicted to function as a negative regulator of Ras signaling by enhancing the intrinsically weak Ras GTPase activity; gap-2 loss-of-function mutations partially suppress the larval lethality of let-23 and let-60 loss-of-function mutations, supporting a role for gap-2 in negative regulation of Ras signaling in vivo; gap-2 can encode at least eight different isoforms that appear to be expressed in a wide variety of tissues including the vulva, gonad, pharynx, neurons, and blast/rectal cells of the tail. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK938.2 Aff_ZK938.2 ZK938.2; 2K128; CE02397; WBGene00014159; WP:CE02397 ViswanathanM et al 2005 S2 daf-16 Resveratrol