Baugh et al 2003, subclass MDpd_PC32, 155 genes Gene list file name: Baugh2003_classMDpd_PC32.txt Type of gene identifier: Affymetrix custom chip Description: Baugh et al 2005, Supplymental Dataset, subclass MDpd_PC32 Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations AC7.2 Aff_AC7.2 soc-2; sur-8; AC7.2; AC7.2a.1; AC7.2a.2; 4F892; CE25736; CE31275; NM_171332; WBGene00004929; WP:CE25736; WP:CE31275 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 AFF_F45D11_39.C Aff_F45D11_39.C AFF_F46F11.8 Aff_F46F11.8 AFF_R144.3 Aff_R144.3 AFF_Y38F2A_6126.E Aff_Y38F2A_6126.E AFF_Y55B1B_119.E Aff_Y55B1B_119.E B0001.2 Aff_B0001.2 B0001.2; 4M912; CE36776; WBGene00007087; WP:CE36776 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated B0244.8 Aff_B0244.8 egg-1; B0244.8; 3G819; CE32094; WBGene00015083; WP:CE32094 LDL receptor Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination B0280.5 Aff_B0280.5 B0280.5; 3I192; CE31868; WBGene00015102; WP:CE31868 B0280.5 encodes a protein with a chitin binding peritrophin-A domain that is required, in conjunction with CEJ-1, for early embryonic development; B0280.5 mRNA is expressed specifically in the adult hermaphrodite germ line, is a direct target of GLD-1, and has an RNAi phenotype consistent with the hypothesis that B0280.5 is an effector of GLD-1 in the germline. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination B0334.5 Aff_B0334.5 B0334.5; 2L789; CE30122; WBGene00007145; WP:CE30122 phytoene synthase precursor ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0361.5 Aff_B0361.5 psd-1; B0361.5; 3I360; CE37076; CE37696; WBGene00015159; WP:CE37076; WP:CE37696 Phosphatidylserine decarboxylase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 B0365.1 Aff_B0365.1 B0365.1; 5N599; CE07719; WBGene00007150; WP:CE07719 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ATP citrate lyase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA B0414.8 Aff_B0414.8 B0414.8; 1G380; CE30413; CE36910; WBGene00015176; WP:CE30413; WP:CE36910 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C01F1.2 Aff_C01F1.2 C01F1.2; 2E591; CE06743; WBGene00015297; WP:CE06743 C01F1.2 is orthologous to the human gene SCO (CYTOCHROME OXIDASE DEFICIENT, YEAST) HOMOLOG 1 (SCO1; OMIM:603644), which when mutated leads to early-onset hepatic failure; the C01F1.2 protein is predicted to be mitochondrial with 68% accuracy. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C01G8.6 Aff_C01G8.6 C01G8.6; 1F868; CE07807; WBGene00015313; WP:CE07807 Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated C04E6.11 Aff_C04E6.11 C04E6.11; 5G396; CE36911; WBGene00015425; WP:CE36911 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C04F12.10 Aff_C04F12.10 Ce-face-1; fce-1; C04F12.10; 1K288; CE19683; NM_060181; WBGene00001405; WP:CE19683 fce-1 encodes an ortholog of 'farnesylated-proteins converting enzyme 1' (FACE-1), and thus probably enables post-translational processing of proteins (such as LET-60/RAS) carrying a C-terminal CaaX motif; FCE-1 protein probably accounts for the EDTA-sensitive, tosylphenylalanylchloromethane-insensitive component of CaaX-proteolytic activity in membrane extracts from C. elegans, and FCE-1 can cleave a farnesylated peptide in vitro; the S. cerevisiae homolog of FCE-1 (Ste24p) cleaves the precursor of yeast a-factor mating pheromone after its farnesylated cysteine residue, and transgenic FCE-1 rescues a mating defect of mutant yeast lacking both the Ste24p and the Rce1p CaaX-proteases. Zinc-binding metalloprotease domain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C04F6.5 Aff_C04F6.5 dhs-27; C04F6.5; CE37079; NM_076190; WBGene00000990; WP:CE37079; XE32 dhs-27 encodes a short-chain dehydrogenase predicted to be mitochondrial. alcohol/ribitol dehydrogenase ViswanathanM et al 2005 S2 daf-16 Resveratrol C06A5.11 Aff_C06A5.3 sir-2.4; C06A5.11; 1G567; CE27656; NM_059332; WBGene00004803; WP:CE27656 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C07D8.6 Aff_C07D8.6 C07D8.6; C07D8.6.1; C07D8.6.2; CE06776; WBGene00015565; WP:CE06776; XH961 aldehyde reductase Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C10F3.1 Aff_C10F3.1 C10F3.1; 5G479; CE08066; WBGene00015677; WP:CE08066 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C14B1.2 Aff_C14B1.2 C14B1.2; 3E791; CE00899; WBGene00007573; WP:CE00899 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C14C10.4 Aff_C14C10.4 C14C10.4; C14C10.4.1; C14C10.4.2; 5N74; CE05283; WBGene00007587; WP:CE05283 Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C14C11.2 Aff_C14C11.2 C14C11.2; 5G143; CE06821; WBGene00015766; WP:CE06821 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C24H10.5 Aff_C24H10.5 uvt-2; C24H10.5; CE29674; NM_076463; WBGene00006861; WP:CE29674; XF690 uvt-2 encodes a protein that contains four EF-hand calcium binding motifs with similarity to human calmodulin; mRNA weakly expressed in L1 through L4 larval stages and in the adult hermaphrodite. EF-hand calcium binding protein C25A1.13 Aff_C25A1.13 C25A1.13; 1K769; CE08379; WBGene00007712; WP:CE08379 NADH-ubiquinone oxidoreductase B8 subunit McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C25G4.4 Aff_C25G4.4 tag-347; C25G4.4; 4N218; CE05305; WBGene00007732; WP:CE05305 SAND domain Jiang et al 2001 Fig1 male-enriched TF, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, GO categories, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C27F2.7 Aff_C27F2.7 C27F2.7; 3G72; CE38942; WBGene00016169; WP:CE38942 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C27H6.4 Aff_C27H6.4 C27H6.4; 5K464; CE08428; CE31322; WBGene00007786; WP:CE08428; WP:CE31322 C30C11.2 Aff_C30C11.2 rpn-3; C30C11.2; C30C11.2.1; C30C11.2.2; 3J537; CE00101; NM_066468; WBGene00004460; WP:CE00101 Diphenol oxidase A2 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C30G12.7 Aff_C30G12.7 puf-8; C30G12.7; 2H586; CE37486; NM_063122; WBGene00004244; WP:CE37486 Jones et al 2001 Dauer specific genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, IVb male soma enriched genes, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit C42C1.11 Aff_C42C1.11 AP-1; C42C1.11; C42C1.11a.1; C42C1.11a.2; C42C1.11c.1; C42C1.11c.2; 4N45; CE24840; CE33564; CE33565; WBGene00016589; WP:CE24840; WP:CE33564; WP:CE33565 peptidase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C43E11.7 Aff_C43E11.7 ndx-7; C43E11.7; 1E808; CE30504; NM_058935; WBGene00003584; WP:CE30504 ndx-7 encodes a NUDIX hydrolase; by sequence comparison, NDX-7 is predicted to function as a pyrophosphatase, and is most closely related to the mouse RP2 protein that has unknown substrate specificity but is regulated transcriptionally by the presence of androgens; in C. elegans, loss of ndx-7 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, consistent with the proposed nonessential roles for Nudix proteins in eliminating potentially toxic nucleotide metabolites from cells and modulating levels of metabolic intermediates by shuttling them into alternative biochemical pathways. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C44B9.3 Aff_C44B9.3 C44B9.3; 3L966; CE05405; WBGene00008080; WP:CE05405 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C44B9.5 Aff_C44B9.5 C44B9.5; 3L989; CE37755; WBGene00008082; WP:CE37755 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C46F11.3 Aff_C46F11.3 C46F11.3; 3E738; CE08774; WBGene00008118; WP:CE08774 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C48B4.6 Aff_C48B4.6 C48B4.6; 3K646; CE00482; WBGene00008169; WP:CE00482 Jones et al 2001 Dauer specific genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset C50F7.4 Aff_C50F7.4 C50F7.4; 4I495; CE04242; SCB2; WBGene00016844; WP:CE04242 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. succinyl-CoA synthetase beta chain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C56C10.10 Aff_C56C10.10 C56C10.10; 2G884; CE02564; WBGene00016966; WP:CE02564 TPR domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated CD4.6 Aff_CD4.6 pas-6; CD4.6; CD4.6.1; CD4.6.2; 5G64; CE16954; NM_072071; WBGene00003927; WP:CE16954 pas-6 encodes a type 1 alpha subunit of the 26S proteasome's 20S protease core particle (CP); PAS-6 is required for embryonic, larval, and germline development and by homology, is predicted to comprise the outer rings of the proteasome and to play a role in selective degradation of ubiquitinated proteins during development; in vitro, PAS-6 interacts with BRP-1, a glutamine/asparagine (Q/N)-rich domain-containing protein conserved amongst nematodes, and with other members of the proteasome. protease McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated D1007.5 Aff_D1007.5 D1007.5; D1007.5a.1; D1007.5a.2; D1007.5b.1; D1007.5b.2; 1F150; CE29034; CE33577; WBGene00017003; WP:CE29034; WP:CE33577 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated D2023.5 Aff_D2023.5 D2023.5; 5M306; CE09075; WBGene00008409; WP:CE09075 thiosulphate sulphurtransferase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA D2030.8 Aff_D2030.8 D2030.8; 1I169; CE28545; WBGene00008418; WP:CE28545 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated D2096.4 Aff_D2096.4 sqv-1; D2096.4; D2096.4.1; D2096.4.2; 4J127; CE04302; NM_069017; WBGene00005019; WP:CE04302 sqv-1 encodes a UDP-glucuronic acid decarboxylase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-1 is coexpressed with the nucleotide-sugar transporter homolog SQV-7 in in the vulva and in oocytes; SQV-1 colocalizes with SQV-5 and SQV-7 to punctate foci (probably the Golgi apparatus) in the cytoplasm of the vulva, the uterus and oocytes, within which SQV-1 may act to promote the biosynthesis of chondroitin glycosaminoglycans; the common requirement for SQV-1 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, McElwee et al 2003 T1 targets of daf-16, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA E02H1.2 Aff_E02H1.2 E02H1.2; 2J878; CE01537; WBGene00008456; WP:CE01537 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. GTP binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F09E5.3 Aff_F09E5.3 F09E5.3; F09E5.3.1; F09E5.3.2; 2F665; CE02610; WBGene00017283; WP:CE02610 Deoxyribose-phosphate aldolase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F13C5.1 Aff_F13C5.1 F13C5.1; CE19383; WBGene00017422; WP:CE19383; XB223 Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F15B10.1 Aff_F15B10.1 F15B10.1; 4H370; CE16987; CE39241; WBGene00017480; WP:CE16987; WP:CE39241 The F15B10.1 gene encodes an ortholog of the Kluyveromyces lactis UDP-N-acetylglucosamine (UPD-GlcNAc) transporter; when expressed in human cells deficient for GDP-fucose transport into the Golgi, F15B10.1 is able to weakly restore such transport (with ~10% efficiency). McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F16D3.4 Aff_F16D3.4 F16D3.4; 1I940; CE09437; WBGene00008887; WP:CE09437 F16D3.4 encodes an ortholog of human TUBULIN-SPECIFIC CHAPERONE D (TBCD; OMIM:604649), also known as tubulin-folding cofactor D; F16D3.4 may be a ligand and effector of the ARL2 ortholog EVL-20. Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F16H11.3 Aff_F16H11.3 F16H11.3; CE04398; NM_076394; WBGene00017532; WP:CE04398; XF264 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F17A9.2 Aff_F17A9.2 F17A9.2; 5G593; CE19798; WBGene00017534; WP:CE19798 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F20D1.3 Aff_F20D1.3 F20D1.3; F20D1.3.1; F20D1.3.2; CE31486; WBGene00008975; WP:CE31486; XP595 F21F3.4 Aff_F21F3.4 F21F3.4; 1F465; CE09534; WBGene00017674; WP:CE09534 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F25H2.5 Aff_F25H2.5 F25H2.5; F25H2.5.1; F25H2.5.2; F25H2.5.3; 1L130; CE09650; WBGene00009119; WP:CE09650 nucleoside diphosphate kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F26H9.4 Aff_F26H9.4 F26H9.4; 1J882; CE09709; WBGene00009176; WP:CE09709 Yeast hypothetical protein YG15 like Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F29C12.4 Aff_F29C12.4 F29C12.4; 2N411; CE19822; WBGene00009246; WP:CE19822 Elongation factor Tu family (contains ATP/GTP binding P-loop), Elongation factor G C-terminus McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated F32D1.6 Aff_F32D1.6 F32D1.6; 5E852; CE09870; WBGene00017985; WP:CE09870 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F35C11.5 Aff_F35C11.5 F35C11.5; 2I545; CE03285; WBGene00009404; WP:CE03285 phospholipase A2 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F38E1.7 Aff_F38E1.7 mom-2; F38E1.7; 5I837; CE17806; NM_072753; WBGene00003395; WP:CE17806 mom-2 encodes a member of the Wnt family of secreted signaling glycoproteins that is required for induction of endodermal (gut) tissue in the 4-cell stage embryo; MOM-2, required in the inducing blastomere (P2) at the 4-cell stage, may be the ligand for MOM-5, a Frizzled homolog, thought to act in the receiving blastomere (EMS); MOM-2 genetically interacts in the same pathway as KIN-19, but parallel to APR-1; MOM-2 also may be a ligand for LIN-18, a Ryk homolog. WNT family protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F43D2.2 Aff_F43D2.2 F43D2.2; 5P112; CE10336; WBGene00009651; WP:CE10336 ViswanathanM et al 2005 S2 sir-2.1 regulated F44G4.3 Aff_F44G4.3 F44G4.3; 2J288; CE02230; WBGene00009713; WP:CE02230 F46E10.10 Aff_F46E10.D F46E10.10; F46E10.10b.1; F46E10.10b.2; F46E10.10c.1; F46E10.10c.2; F46E10.D; F46E10.I; 5G996; CE20820; CE33096; CE33097; WBGene00018491; WP:CE20820; WP:CE33096; WP:CE33097 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Link et al 2003 T2 Abeta repressed, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F46F11.2 Aff_F46F11.2 cey-2; F46F11.2; F46F11.2.1; F46F11.2.2; 1G189; CE10598; NM_059244; WBGene00000473; WP:CE10598 cey-2 encodes a cold-shock/Y-box domain-containing protein; by homology, CEY-2 is predicted to function as either an RNA-binding protein involved in translation or RNA processing, or a DNA-binding protein involved in transcriptional regulation; cey-2 mRNA is expressed maternally in the early embryo, in a pattern characteristic of class II maternal RNAs, which are initially detected throughout the embryo but restricted to the P, or germline, lineage as cell division progresses; as loss of cey-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cey-2 in C. elegans development and/or behavior is not yet known. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F48C1.6 Aff_F48C1.6 F48C1.6; 1F886; CE10742; WBGene00018599; WP:CE10742 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F52C6.8 Aff_F52C6.8 bath-4; F52C6.8; 2C172; CE10816; WBGene00018665; WP:CE10816 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F54B3.3 Aff_F54B3.3 F54B3.3; F54B3.3.1; F54B3.3.2; F54B3.3.3; 2K539; CE35878; WBGene00010015; WP:CE35878 ATPases associated with various cellular activities (AAA) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F54C8.2 Aff_F54C8.2 F54C8.2; 3K519; CE00188; WBGene00010036; WP:CE00188 Histone H3 similarity Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, Reinke et al 2004, IVb male soma enriched genes F54C9.8 Aff_F54C9.8 puf-5; F54C9.8; 2I867; CE02258; NM_063413; WBGene00004241; WP:CE02258 Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain) (6 domains) Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination F54E12.2 Aff_F54E12.2 F54E12.2; F54E12.2.1; F54E12.2.2; 4M98; CE11083; WBGene00010061; WP:CE11083 helicase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F55A12.2 Aff_F55A12.2 F55A12.2; F55A12.2d.1; F55A12.2d.2; 1F933; CE29396; CE30540; CE34317; CE34318; WBGene00018863; WP:CE29396; WP:CE30540; WP:CE34317; WP:CE34318 ViswanathanM et al 2005 S2 sir-2.1 regulated F56A4.12 Aff_F56A4.A F56A4.12; 5C954; CE25010; WBGene00018920; WP:CE25010 ViswanathanM et al 2005 S2 sir-2.1 regulated F56B3.8 Aff_F56B3.8 F56B3.8; 4B529; CE34320; WBGene00018932; WP:CE34320 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56G4.5 Aff_Y53H1C.A F56G4.5; F56G4.5.1; F56G4.5.2; 1L979; CE23786; WBGene00010160; WP:CE23786 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Thioredoxins McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F57B10.3 Aff_F57B10.3 F57B10.3; F57B10.3b.1; F57B10.3b.2; F57B10.3b.3; F57B10.3b.4; 1H147; CE11302; CE33113; WBGene00019001; WP:CE11302; WP:CE33113 F57B10.3 encodes an experimentally confirmed cofactor-independent phosphoglycerate mutase that is essential for embryonic and larval viability, and for normal body morphology; paradoxically, F57B10.3 is also required for normally short livespan (in mass RNAi screens for Age phenotypes); F57B10.3 is expressed widely in larvae and adults, with highest expression in the nerve ring, intestine and body wall muscles; F57B10.3 probably functions in glycolytic and gluconeogenic metabolism. ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F57C2.2 Aff_F57C2.2 F57C2.2; 2O804; CE16153; WBGene00010194; WP:CE16153 BTB (also known as BR-C/Ttk) domain. Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated F58B3.5 Aff_F58B3.5 mrs-1; F58B3.5; 4M398; CE06007; NM_069795; WBGene00003415; WP:CE06007 mrs-1 encodes a predicted cytoplasmic methionyl-tRNA synthetase (MetRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of methionine to its cognate tRNA and is thus required for protein biosynthesis; MRS-1 is essential for embryogenesis and required also for a normal rate of postembryonic growth. methionyl-tRNA synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol F59B2.7 Aff_F59B2.7 rab-6.1; F59B2.7; 3K94; CE00234; NM_066592; WBGene00004269; WP:CE00234 Rab6 (ras protein) McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F59F4.4 Aff_F59F4.4 acl-1; F59F4.4; CE11552; NM_078205; WBGene00010339; WP:CE11552; XQ469 1-acyl-SN-glycerol-3-phosphate acyltransferase Jones et al 2001 Non dauer genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched H02I12.1 Aff_H02I12.1 H02I12.1; 4M141; CE37527; WBGene00010351; WP:CE37527 Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated H02I12.5 Aff_H02I12.5 H02I12.5; 4M166; CE16162; WBGene00010353; WP:CE16162 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated H11L12.1 Aff_H11L12.1 H11L12.1; CE20957; WBGene00019189; WP:CE20957; XS322 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K01C8.3 Aff_K01C8.3 adc-1; tdc-1; K01C8.3; 2I563; CE21011; CE28344; NM_063342; NM_063343; WBGene00006562; WP:CE21011; WP:CE28344 aromatic-L-amino-acid decarboxylase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, IVb male soma enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K01C8.6 Aff_K01C8.6 K01C8.6; 2I566; CE02267; WBGene00010458; WP:CE02267 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ViswanathanM et al 2005 S2 sir-2.1 regulated K01C8.7 Aff_K01C8.7 K01C8.7; 2I565; CE02268; WBGene00010459; WP:CE02268 Mitochondrial carrier proteins McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K01D12.12 Aff_K01D12.12 cdr-6; K01D12.12; 5M892; CE06051; NM_073712; WBGene00010471; WP:CE06051 glutathione S-transferase ViswanathanM et al 2005 S2 sir-2.1 regulated K02D10.1 Aff_K02D10.1 K02D10.1; K02D10.1b.1; K02D10.1b.2; 3J865; CE17151; CE29423; WBGene00019301; WP:CE17151; WP:CE29423 4-NITROPHENYLPHOSPHATASE McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K04F10.6 Aff_K04F10.6 rde-3; K04F10.6; 1G930; CE11740; CE33137; NM_059433; NM_182080; WBGene00004325; WBGene00019398; WP:CE11740; WP:CE33137 rde-3 encodes a nucleotidyltransferase that is a member of the polymerase beta nucleotidyltransferase superfamily that includes poly(A) polymerases, 2-5 oligoadenylate synthetases, C. elegans GLD-2, and S. cerevisiae Trf4p; by homology, RDE-3 is predicted to function as a poly(A) polymerase whose activity is required for meiotic chromosome segregation, negative regulation of DNA transposition, non-transgene-induced RNAi (i.e. RNAi via feeding is affected, whereas RNAi via expression of sense and antisense RNA from a transgene is not), fertility, and viability; analysis of siRNA levels in rde-3 mutant animals indicates that during RNAi, RDE-3 activity is required at a point upstream of siRNA accumulation; neither the precise mechanistic role of RDE-3 in posttranscriptional silencing, nor the RDE-3 expression pattern, is yet known. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K04G2.6 Aff_K04G2.6 K04G2.6; K04G2.6.1; K04G2.6.2; 1I619; CE06100; WBGene00010565; WP:CE06100 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K07C11.9 Aff_K07C11.9 cogc-6; K07C11.9; 5I700; CE07351; WBGene00019481; WP:CE07351 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K07H8.3 Aff_K07H8.3 K07H8.3; 4J55; CE18023; WBGene00019505; WP:CE18023 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K08F4.3 Aff_K08F4.3 K08F4.3; 4K895; CE06151; WBGene00010678; WP:CE06151 translocon-associated protein Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated K08H2.3 Aff_K08H2.3 K08H2.3; CE06161; WBGene00010690; WP:CE06161; XN855 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R01H2.3 Aff_R01H2.3 egg-2; R01H2.3; 3I146; CE00802; WBGene00019811; WP:CE00802 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R03D7.7 Aff_R03D7.7 nos-1; R03D7.7; 2L242; CE01614; NM_063957; WBGene00003783; WP:CE01614 nos-1 encodes an putative RNA-binding protein that contains a zinc-binding motif homologous to that of Drosophila Nanos, a posterior-group protein required for embryonic patterning and primordial germ cell development; in C. elegans, NOS-1 is required redundantly with NOS-2, a second Nanos homolog, for maintenance of germ cell viability during postembryonic development and for preventing primordial germ cells from dividing in the absence of food; nos-1 mRNA is expressed dynamically in the embryo, with early expression seen throughout the embryo and later expression restricted solely to germline blastomeres; nos-1 mRNA becomes undetectable after the 200-cell stage, but reappears later at the 550-cell stage; NOS-1 protein is not detectable in germline blastomeres until the 550-cell stage, suggesting that NOS-1 might actually function zygotically in germline specification. nanos protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R05F9.6 Aff_R05F9.6 R05F9.6; 2F181; CE04809; WBGene00019890; WP:CE04809 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. phosphoglucomutase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched R06C7.4 Aff_R06C7.4 R06C7.4; 1H821; CE06247; WBGene00011063; WP:CE06247 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination R06F6.9 Aff_R06F6.9 acbp-2; ech-4; R06F6.9; 2L111; CE01625; NM_063929; WBGene00001153; WP:CE01625 enoyl CoA hydratase/isomerase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Metabolism, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 R09B3.4 Aff_R09B3.4 ubc-12; R09B3.4; 1M503; CE16309; NM_060623; WBGene00006707; WP:CE16309 The ubc-12 gene encodes a ubiquitin-conjugating enzyme whose substrate is NED-8, and which is required for both embryogenesis and terminal hypodermal differentiation; ubc-12(RNAi) mutants either arrest during embryonic development or show pleotropic defects (e.g., vulval eversion during the L4 stage), as well as defective alae. Ubiquitin-conjugating enzymes ViswanathanM et al 2005 S2 sir-2.1 regulated R107.7 Aff_R107.7 gst-1; R107.7; R107.7.1; R107.7.2; 3K149; CE00302; NM_066605; WBGene00001749; WP:CE00302 gst-1 encodes a putative glutathione S-transferase with highest similarity to the pi class. glutathione S-transferase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination R10E4.5 Aff_R10E4.5 R10E4.5; 3F380; CE03559; WBGene00011201; WP:CE03559 endonuclease McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated R12E2.10 Aff_R12E2.10 R12E2.10; 1E738; CE18142; WBGene00020035; WP:CE18142 protein-tyrosine phosphatase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R166.3 Aff_R166.3 R166.3; 2K828; CE03582; WBGene00011303; WP:CE03582 The R166.3 gene encodes an unfamiliar protein, with homologs in yeast and archaea, that is orthologous to the human gene ALPORT SYNDROME, MENTAL RETARDATION, MIDFACE HYPOPLASIA, AND ELLIPTOCYTOSIS CHROMOSOMAL REGION GENE 1 (AMMECR1; OMIM:300195); AMMECR1, when mutated, may be at least partially responsible for mental retardation, midface hypoplasia, or elliptocytosis. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R186.3 Aff_R186.3 R186.3; 5N446; CE12874; WBGene00011306; WP:CE12874 signal recognition particle receptor beta subunit like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T01G5.7 Aff_T01G5.7 T01G5.7; 5P593; CE12986; WBGene00011342; WP:CE12986 Zinc finger, C3HC4 type (RING finger) Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T02G5.8 Aff_T02G5.8 kat-1; T02G5.8; 2H367; CE29990; NM_063054; WBGene00002183; WP:CE29990 kat-1 encodes a homolog of the human gene ACAT1, which when mutated leads to alpha-methylacetoaceticaciduria (OMIM:203750). acetoacetyl-C0A thiolase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T03F1.3 Aff_T03F1.3 T03F1.3; 1E435; CE13100; WBGene00020185; WP:CE13100 T03F1.3 is orthologous to the human gene PHOSPHOGLYCERETE KINASE 1 (PGK1; OMIM:311800), which when mutated leads to hemolytic anemia and neurologic disturbances. phosphoglycerate kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 T03F1.7 Aff_T03F1.7 T03F1.7; 1E420; CE30685; WBGene00020189; WP:CE30685 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T04A8.11 Aff_T04A8.11 T04A8.11; 3F793; CE01066; WBGene00011412; WP:CE01066 50S ribosomal protein L16 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T05A6.1 Aff_T05A6.1 cki-1; T05A6.1; 2I101; CE03628; NM_063240; WBGene00000516; WP:CE03628 cki-1 encodes a homolog of the mammalian cyclin-dependent kinase inhibitor p27/KIP1 that is required for the arrest of cell division in larval blast lineages, dauer larvae and starved L1 larvae; excess CKI-1 expression prematurely stops cell division while cki-1(RNAi) induces extra cell divisions, indicating that CKI-1 quantitatively regulates the amount of mitosis in postembryonic worms. Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order T05G11.1 Aff_T05G11.1 T05G11.1; 5Q408; CE18930; WBGene00011505; WP:CE18930 Zinc finger, C2H2 (2 domains) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination T06E8.1 Aff_T06E8.1 acl-2; T06E8.1; 5K510; CE06378; NM_073177; WBGene00011543; WP:CE06378 T06E8.1 is orthologous to the human gene 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 2 (LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE, BETA) (AGPAT2; OMIM:603100), which when mutated leads to disease; T06E8.1 protein is predicted to be mitochondrial. 1-acyl-SN-glycerol-3-phophate acyltransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T06H11.4 Aff_T06H11.4 moc-1; T06H11.4; CE31596; NM_077299; WBGene00003384; WP:CE31596; XK756 moc-1 encodes an ortholog of human GEPHYRIN (GPHN; OMIM:603930), which when mutated leads to molybdenum cofactor (MoCo) deficiency; MOC-1 is also paralogous to LIN-46. gephyrin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated T11F8.3 Aff_T11F8.3 rme-2; T11F8.3; 4G237; CE22368; NM_068414; WBGene00004374; WP:CE22368 LDL-like receptor Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination T12A2.8 Aff_T12A2.8 T12A2.8; T12A2.8.1; T12A2.8.2; 3H336; CE01401; WBGene00020442; WP:CE01401 DNA repair protein Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T12D8.8 Aff_T12D8.8 T12D8.8; T12D8.8.1; T12D8.8.2; T12D8.8.3; 3O704; CE16405; WBGene00011735; WP:CE16405 TPR Domain (2 domains) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T12G3.4 Aff_T12G3.4 T12G3.4; 4M813; CE06440; WBGene00011739; WP:CE06440 strictosidine synthase like ViswanathanM et al 2005 S2 sir-2.1 regulated T17E9.2 Aff_T17E9.2 T17E9.2; T17E9.2c.1; T17E9.2c.2; 3H204; CE01406; CE28669; CE31611; WBGene00020549; WP:CE01406; WP:CE28669; WP:CE31611 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T20F7.1 Aff_T20F7.1 T20F7.1; CE33698; WBGene00020630; WP:CE33698; XR491 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen T21B10.1 Aff_T21B10.1 T21B10.1; 2J221; CE03683; WBGene00011883; WP:CE03683 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T21C9.2 Aff_T21C9.2 vps-54; T21C9.2; 5L46; CE31365; NM_073310; WBGene00006934; WP:CE31365 The vps-54 gene encodes an ortholog of VPS54 in S. cerevisiae, a protein involved in vacuolar trafficking. Zinc finger, C2H2 type McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated T23B12.2 Aff_T23B12.2 T23B12.2; 5I949; CE14028; WBGene00020717; WP:CE14028 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ribosomal protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T24D1.3 Aff_T24D1.3 T24D1.3; 1K536; CE14166; WBGene00011986; WP:CE14166 Golden et al 2004, N2 vs daf-2 different genes at , Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T25D3.2 Aff_T25D3.2 T25D3.2; 2A446; CE19599; WBGene00020796; WP:CE19599 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated T27E9.4 Aff_T27E9.4 kel-3; T27E9.4; T27E9.4a.1; T27E9.4a.2; T27E9.4a.3; 3O559; CE29824; CE29825; NM_067383; NM_067384; WBGene00002185; WP:CE29824; WP:CE29825 ring canal protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated W01A11.2 Aff_W01A11.2 W01A11.2; 5G979; CE14392; WBGene00020910; WP:CE14392 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated W05F2.3 Aff_W05F2.3 W05F2.3; 1D936; CE14616; WBGene00021035; WP:CE14616 Jones et al 2001 Non dauer genes P<0.05, Jones et al 2001 T3 20 most abundant Mixed-stage, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination W08F4.3 Aff_W08F4.3 W08F4.3; W08F4.3.1; W08F4.3.2; 2A871; CE14716; WBGene00021093; WP:CE14716 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated W09B7.2 Aff_W09B7.B W09B7.2; W09B7.B; 5J305; WBGene00021107 Y105E8B.5 Aff_Y105E8A.K Y105E8B.5; 1P253; CE24099; WBGene00013690; WP:CE24099 The Y105E8B. Y106G6H.14 Aff_Y106G6H.14 Y106G6H.14; 1L48; CE24111; WBGene00013724; WP:CE24111 Src homology domain 3 ; Ank repeat Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated Y17G9B.9 Aff_Y17G9B.A Y17G9B.9; 4F524; CE24188; WBGene00021206; WP:CE24188 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y24D9A.8 Aff_Y24D9A_29.F Y24D9A.8; Y24D9A.8a.1; Y24D9A.8a.2; Y24D9A.8a.3; Y24D9A.8b.1; Y24D9A.8b.2; 4F153; CE28974; CE30402; WBGene00021286; WP:CE28974; WP:CE30402 Y24D9A.8 is orthologous to the human gene TRANSALDOLASE 1 (TALDO1; OMIM:602063), which when mutated leads to disease. Y39E4B.5 Aff_Y39E4B.L Y39E4B.5; Y39E4B.L; 3O261; CE21717; WBGene00012716; WP:CE21717 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y40B10A.1 Aff_Y40B10A_106.C lbp-9; Y40B10A.1; Y40B10A.1b.1; Y40B10A.1b.2; 5C547; CE26077; CE39188; NM_071161; WBGene00021486; WP:CE26077; WP:CE39188 Reinke et al 2004, herm soma enriched genes Y45F10A.2 Aff_Y45F10A.2 puf-3; Y45F10A.2; Y45F10A.2.1; Y45F10A.2.2; 4O276; CE18393; NM_070205; WBGene00004239; WP:CE18393 The puf-3 gene encodes a predicted RNA binding protein that is a member of the conserved PUF (Pumilio and FBF) family of RNA binding proteins; PUF-3 is expressed in the ovary and is required for multiple aspects of early embryogenesis including proper cell cycle timing, spindle positioning, and formation of the polar bodies and pronuclei. Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain) Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination Y46H3A.7 Aff_Y46H3A.H Y46H3A.7; CE38646; WBGene00044344; WP:CE38646 Y47G6A.20 Aff_Y47G6A_245.F rnp-6; Y47G6A.20; 1E108; CE24365; CE24366; CE31375; NM_058775; NM_058776; NM_170843; WBGene00004389; WP:CE24365; WP:CE24366; WP:CE31375 rnp-6 encodes an ortholog of HALF-PINT in D. melanogaster and FBP Interacting Repressor (FIR)/PUF60 in mammals, predicted to be involved in mRNA splicing regulation, mRNA localization, or transcriptional regulation via TFIIH. Y48B6A.13 Aff_Y48B6A.L Y48B6A.13; Y48B6A.13b.1; Y48B6A.13b.2; 2O512; CE22128; CE22129; WBGene00012984; WP:CE22128; WP:CE22129 Y50D7A.9 Aff_Y50D7_165.D Y50D7A.9; 3A905; CE28994; WBGene00021757; WP:CE28994 Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y52B11A.2 Aff_Y52B11A.2 Y52B11A.2; 1L558; CE20291; CE36243; WBGene00013122; WP:CE20291; WP:CE36243 Uncharacterized protein family UPF0029 McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories Y53C12B.1 Aff_Y53C12B.1 Y53C12B.1; 2K34; CE14894; WBGene00013143; WP:CE14894 WD domain, G-beta repeats (4 domains) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y54E10A.7 Aff_Y54E10A_159.B Y54E10A.7; Y54E10A_159.B; 1D731; CE38572; WBGene00021829; WP:CE38572 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y54G2A.36 Aff_Y94H6A_148.S Y54G2A.36; 4D661; CE34417; WBGene00021898; WP:CE34417 Y57A10A.30 Aff_Y57A10A.JJ ife-5; Y57A10A.30; Y57A10A.30b.1; Y57A10A.30b.2; 2M573; CE22608; CE25509; NM_064207; WBGene00002063; WP:CE22608; WP:CE25509 ife-5 encodes a member of the Initiation Factor 4E (eIF4E) family; it is expressed in the germ line. Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated Y66A7A.2 Aff_Y66A7A.2 Y66A7A.2; 3M576; CE22751; WBGene00013422; WP:CE22751 Y71F9AL.8 Aff_Y71F9A_294.E Y71F9AL.8; 1D447; CE25560; WBGene00022113; WP:CE25560 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y71F9AM.4 Aff_Y71F9A_269.A cogc-3; mig-29; Y71F9AM.4; 1D513; CE33242; CE37070; WBGene00022121; WP:CE33242; WP:CE37070 Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y75B12B.2 Aff_Y75B12B.2 cyn-7; cyp-7; Y75B12B.2; Y75B12B.2.1; Y75B12B.2.2; Y75B12B.2.3; 5P666; CE20371; NM_074348; WBGene00000883; WP:CE20371 cyp-7 encodes a cyclophilin A isoform; while not tested peptidyl-prolyl isomerase activity in vitro, it is very similar to CYP-3 and closely resembles the prototypical CypA, and is therefore likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; CYP-7 was required for embryonic viability in one set of mass RNAi assays. Peptidyl-prolyl cis-trans isomerases McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated Y82E9BR.14 Aff_Y119D3_446.D Y82E9BR.14; Y82E9BR.14a.1; Y82E9BR.14a.2; 3C500; CE27038; CE34433; WBGene00022347; WP:CE27038; WP:CE34433 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph ZK1098.4 Aff_ZK1098.4 ZK1098.4; 3K633; CE00367; WBGene00014221; WP:CE00367 GCN3 (yeast transcription activator) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1236.1 Aff_ZK1236.1 ZK1236.1; 3J519; CE01446; WBGene00022862; WP:CE01446 homology with E.coli lepA protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK1248.3 Aff_ZK1248.3 ehs-1; ZK1248.3; 2G113; CE02903; CE32289; NM_062754; WBGene00001224; WP:CE02903; WP:CE32289 The ehs-1 gene encodes an ortholog of mammalian EPS15 that probably functions in endocytosis. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1307.5 Aff_ZK1307.5 spe-2; sqv-8; ZK1307.5; 2J939; CE01694; NM_063675; WBGene00005026; WP:CE01694 The sqv-8 gene encodes a glucuronyl transferase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-8 is homologous to three distinct glucuronyl transferases (GlcAT-I, GlcAT-P and GlcAT-D) that play a role in the synthesis of different glycoconjugates; the common requirement for SQV-8 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E ZK829.5 Aff_ZK829.5 tbx-36; ZK829.5; 4M717; CE06653; NM_069865; WBGene00006555; WP:CE06653 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK858.7 Aff_ZK858.7 ZK858.7; 1J718; CE35204; WBGene00014120; WP:CE35204 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated