Baugh et al 2003, subclass E_101min, 325 genes Gene list file name: Baugh2003_classEpi_101min.txt Type of gene identifier: Affymetrix custom chip Description: Baugh et al 2005, Supplymental Dataset, subclass E_101min Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations AFF_AC8.J Aff_AC8.J AFF_C25D7.10 Aff_C25D7.10 AFF_C33A11.2 Aff_C33A11.2 AFF_E01A2.I Aff_E01A2.I AFF_F44A2.6 Aff_F44A2.6 AFF_W02A2.E Aff_W02A2.E AFF_Y119D3_465.L Aff_Y119D3_465.L AFF_Y25C1A.A Aff_Y25C1A.A AFF_Y52B11C.1 Aff_Y52B11C.1 AFF_Y53G8A_2706.A Aff_Y53G8A_2706.A AFF_Y59A8A.H Aff_Y59A8A.H AFF_Y71F9A_262.A Aff_Y71F9A_262.A AFF_Y71H2_389.E Aff_Y71H2_389.E B0218.3 Aff_B0218.3 pmk-1; B0218.3; 4I913; CE06686; NM_068964; WBGene00004055; WP:CE06686 pmk-1 encodes a mitogen-activated protein kinase (MAPK), orthologous to human p38 MAPK (OMIM:600289), that is required for eliciting gonadal programmed cell death in response to Salmonella enterica infection; PMK-1 lies upstream of CED-9, a negative regulator of apoptosis, in the programmed cell death pathway. ser/thr kinases McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0280.10 Aff_B0280.10 B0280.10; 3I222; CE29533; WBGene00015105; WP:CE29533 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0507.1 Aff_B0507.1 B0507.1; 5J259; CE28815; WBGene00015218; WP:CE28815 Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 B0507.3 Aff_B0507.3 B0507.3; 5J251; CE07762; CE39664; WBGene00015220; WP:CE07762; WP:CE39664 B0547.1 Aff_B0547.1 csn-5; B0547.1; B0547.1.1; B0547.1.2; 4G415; CE06722; NM_068440; WBGene00000817; WP:CE06722 csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated B0563.4 Aff_B0563.3 tag-132; B0563.4; CE30843; WBGene00006479; WP:CE30843; XJ777 ViswanathanM et al 2005 S2 sir-2.1 regulated C01B10.5 Aff_C01B10.5 hil-7; C01B10.5; C01B10.5b.1; C01B10.5b.2; H1.Q; 4H411; CE06736; CE26856; CE26857; CE33357; NM_068626; WBGene00001858; WP:CE06736; WP:CE26856; WP:CE26857; WP:CE33357 hil-7 encodes a histone H1.1 isoform that is required in the germline for chromatin silencing (assayed by silencing of transgenic DNA), for proliferation and differentiation, and for fertility; hil-7(RNAi) phenotypes resemble the Mes phenotype resulting from the desilencing of genes required for somatic differentiation in the germline; HIL-7 is required in both the hermaphrodite and the male germlines, and is ubiquitously expressed in all nuclei (somatic and germline). C01F4.2 Aff_F57C9.8 C01F4.2; 1F420; CE30414; CE33358; WBGene00015303; WP:CE30414; WP:CE33358 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C01G6.4 Aff_C01G6.4 C01G6.4; 2J562; CE00866; WBGene00007226; WP:CE00866 Zinc finger, C3HC4 type (RING finger) ViswanathanM et al 2005 S2 sir-2.1 regulated C01G8.9 Aff_C01G8.7 C01G8.9; 1F870; CE30415; CE33359; WBGene00015314; WP:CE30415; WP:CE33359 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C03C10.1 Aff_C03C10.1 kin-19; C03C10.1; C03C10.1.1; C03C10.1.2; C03C10.1.3; 3F174; CE00872; NM_065417; WBGene00002202; WP:CE00872 kin-19 encodes a serine/threonine kinase orthologous to human casein kinase I, alpha 1 (CSNK1A1, OMIM:600505); KIN-19 appears to be a component of the non-canonical Wnt signaling pathway that regulates endoderm formation in the early embryo; kin-19(RNAi) and mom-2(RNAi) enhance apr-1(RNAi), but not RNAi of each other. casein Kinase I McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C03H12.1 Aff_ZK662.1 C03H12.1; CE35380; WBGene00007284; WP:CE35380; XQ313 C05D9.5 Aff_C05D9.5 ife-4; C05D9.5; CE07931; NM_075809; WBGene00002062; WP:CE07931; XB723 The ife-4 gene encodes a member of the Initiation Factor 4E (eIF4E) family. initiation factor 4E (EIF-4E) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C06A1.1 Aff_C06A1.1 cdc-48.1; phi-31; C06A1.1; 2K850; CE02114; NM_063872; WBGene00007352; WP:CE02114 transitional endoplasmic reticulum ATPase homolog 1 (P97 protein) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C06A6.5 Aff_C06A6.5 C06A6.5; 4I598; CE27661; WBGene00015510; WP:CE27661 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C06B8.7 Aff_C06B8.7 C06B8.7; 5P989; CE30854; WBGene00007372; WP:CE30854 Human M130 antigen like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated C07G1.5 Aff_C07G1.5 hgrs-1; pqn-9; C07G1.5; 4I966; CE32574; NM_068974; WBGene00004101; WP:CE32574 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C08B11.7 Aff_C08B11.7 ubh-4; C08B11.7; 2I328; CE36913; NM_063283; WBGene00006724; WP:CE36913 thiolesterase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C09D4.2 Aff_C09D4.2 C09D4.2; 1G59; CE08031; WBGene00015633; WP:CE08031 Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C11G6.2 Aff_C11G6.2 C11G6.2; CE05256; WBGene00007523; WP:CE05256; XQ943 helicase like C13G3.3 Aff_C13G3.3 C13G3.3; C13G3.3a.1; C13G3.3a.2; C13G3.3b.1; C13G3.3b.2; 5L508; CE05279; CE20505; WBGene00007554; WP:CE05279; WP:CE20505 proteion phosphatase Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C13G5.1 Aff_C13G5.1 ceh-16; C13G5.1; 3J715; CE37477; NM_066497; WBGene00000439; WP:CE37477 ceh-16 encodes a protein that contains a homeobox domain. Engrailed homeotic protein Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C14A11.6 Aff_C14A11.6 C14A11.6; CE08154; WBGene00015751; WP:CE08154; XD426 C14B1.3 Aff_C14B1.3 C14B1.3; 3E793; CE00900; WBGene00007574; WP:CE00900 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C14B9.8 Aff_C14B9.8 C14B9.8; 3J230; CE38273; WBGene00015754; WP:CE38273 C14B9.8 is orthologous to the human gene PHOSPHORYLASE KINASE, LIVER, ALPHA-2 SUBUNIT (PHKA2; OMIM:306000), which when mutated leads to liver glycogenosis. Phosphorylase kinase Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit C14C10.4 Aff_C14C10.4 C14C10.4; C14C10.4.1; C14C10.4.2; 5N74; CE05283; WBGene00007587; WP:CE05283 Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C15H9.8 Aff_C15H9.8 prx-3; C15H9.8; CE04000; NM_076624; WBGene00004193; WP:CE04000; XG732 prx-3 is orthologous to the human gene PEROXISOMAL BIOGENESIS FACTOR 3 (PEX3; OMIM:603164), which when mutated leads to Zellweger syndrome of complementation group G. ViswanathanM et al 2005 S2 sir-2.1 regulated C16C10.5 Aff_C16C10.5 C16C10.5; 3F260; CE01496; WBGene00007626; WP:CE01496 Glutaredoxin, Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan C16D9.6 Aff_C16D9.6 C16D9.6; 5I726; CE35240; WBGene00015861; WP:CE35240 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C18A3.5 Aff_C18A3.5 C18A3.5; C18A3.5e.1; C18A3.5e.2; C18A3.5f.1; C18A3.5f.2; C18A3.5f.3; C18A3.5f.4; C18A3.5f.5; 2G2; CE27708; CE27709; CE27710; CE32130; CE32131; WBGene00015943; WP:CE27708; WP:CE27709; WP:CE27710; WP:CE32130; WP:CE32131 RNA binding protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma C18C4.10 Aff_C18C4.10 klc-2; C18C4.10; C18C4.10b.1; C18C4.10b.2; C18C4.10b.3; C18C4.10b.4; C18C4.10b.5; C18C4.10c.1; C18C4.10c.2; C18C4.10d.1; C18C4.10d.2; 5G58; CE27362; CE32802; CE32803; CE36917; WBGene00002215; WP:CE27362; WP:CE32802; WP:CE32803; WP:CE36917 klc-2 encodes a kinesin light chain and was identified as a protein that interacts with UNC-16 by the yeast two-hybrid system, this association suggests that KLC-2 may be involved in the regulation of synaptic vesicle localization by the UNC-16-JNK signaling complex. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C24F3.2 Aff_C24F3.2 C24F3.2; 4K987; CE18519; WBGene00007697; WP:CE18519 Dual specificity phosphatase, catalytic domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C24G6.4 Aff_C24G6.4 Csr-1; nhr-279; nhr-47; C24G6.4; C24G6.4.1; C24G6.4.2; 5F989; CE27727; NM_072054; WBGene00003637; WP:CE27727 nhr-47 is predicted to encode a nuclear hormone receptor (NHR); gene expression of nhr-47 appears to be induced upon exposure of worm cultures to estradiol. zinc finger protein ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C25G6.2 Aff_C25G6.2 tsp-9; C25G6.2; CE04083; NM_075831; WBGene00006635; WP:CE04083; XB865 transpanin ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C25G6.5 Aff_C25G6.5 C25G6.5; CE04086; WBGene00016110; WP:CE04086; XB868 G-protein coupled receptor (family 1) Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C26E6.6 Aff_C26E6.6 C26E6.6; C26E6.6.1; C26E6.6.2; 3G25; CE39477; WBGene00016142; WP:CE39477 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Ribosomal protein L3 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C27C12.1 Aff_C27C12.1 C27C12.1; CE05318; WBGene00007771; WP:CE05318; XP470 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C27F2.5 Aff_C27F2.5 C27F2.5; C27F2.5.1; C27F2.5.2; 3G50; CE26875; WBGene00016167; WP:CE26875 S. cerevisiae Snf8p McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C29E4.5 Aff_C29E4.5 tag-250; C29E4.5; 3J8; CE29682; CE38589; WBGene00016203; WP:CE29682; WP:CE38589 C30B5.2 Aff_C30B5.2 C30B5.2; 2G487; CE31889; CE31890; WBGene00016244; WP:CE31889; WP:CE31890 ViswanathanM et al 2005 S2 sir-2.1 regulated C31E10.6 Aff_C31E10.6 C31E10.6; CE08506; WBGene00007847; WP:CE08506; XO617 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C32B5.15 Aff_C32B5.15 C32B5.15; 2B258; CE08523; WBGene00016308; WP:CE08523 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C32B5.9 Aff_C32B5.9 C32B5.9; 2B247; CE08517; WBGene00016302; WP:CE08517 ViswanathanM et al 2005 S2 daf-16 Resveratrol C33E10.2 Aff_C33E10.2 fbxa-120; C33E10.2; CE17491; WBGene00016346; WP:CE17491; XR913 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C33H5.9 Aff_C33H5.9 C33H5.9; 4I544; CE04152; WBGene00016376; WP:CE04152 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C34E11.1 Aff_C34E11.1 rsd-3; C34E11.1; C34E11.1.1; C34E11.1.2; CE03062; NM_077572; WBGene00004682; WP:CE03062; XM421 yeast hypothetical L8167.6 like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C34G6.5 Aff_C34G6.5 C34G6.5; 1G449; CE26909; WBGene00016421; WP:CE26909 ser/thr-protein kinase Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E C34G6.7 Aff_C34G6.7 pqn-19; C34G6.7; C34G6.7a.1; C34G6.7a.2; C34G6.7b.1; C34G6.7b.2; 1G480; CE29700; CE32816; NM_059309; NM_182013; WBGene00004109; WP:CE29700; WP:CE32816 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C35D10.8 Aff_C35D10.8 C35D10.8; 3F945; CE29702; WBGene00016445; WP:CE29702 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order C35D10.9 Aff_C35D10.9 ced-4; C35D10.9; 3F943; CE01203; CE38154; WBGene00000418; WP:CE01203; WP:CE38154 ced-4 encodes a novel protein; along with CED-3, CED-4 is required for the initiation of programmed cell death; accordingly, genetic analyses indicate that ced-3 and ced-4 function upstream of ced-1, ced-2, and nuc-1 in the programmed cell death pathway; in yeast two-hybrid experiments, and upon coexpression in mammalian cells, CED-4 interacts with CED-9, an anti-apoptotic BCL-2 homolog; coexpression of CED-4 and CED-9 results in redistribution of CED-4 from the cytosol to organellar membranes, suggesting that CED-9 may negatively regulate CED-4 activity by sequestering CED-4 to intracellular membranes. Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C36E8.3 Aff_C36E8.3 C36E8.3; 3F99; CE30889; WBGene00007982; WP:CE30889 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol C38C3.5 Aff_F53E2.C UNC-60A; unc-60; unc-66; C38C3.5; C38C3.5c.1; C38C3.5c.2; C38C3.5c.3; 5B957; CE20547; CE20549; CE31893; NM_071026; WBGene00006794; WP:CE20547; WP:CE20549; WP:CE31893 unc-60 encodes orthologs of actin depolymerizing factor/cofilin, actin-binding proteins that regulate actin filament dynamics; one UNC-60 isoform, UNC-60A, primarily binds G-actin, depolymerizes actin filaments, and inhibits actin polymerization; UNC-60A is essential during early embryonic development for polar body extrusion, cytokinesis, and embryonic patterning; UNC-60B, which does not inhibit actin polymerization, binds F- and G-actin and influences the rate of actin polymerization by the UNC-60B:actin ratio; UNC-60B is required for actin filament organization in body wall muscle, locomotion, and for efficient actin filament disassembly by UNC-78, an actin interactin protein 1 (AIP1) ortholog; UNC-60A and UNC-60B are differentially expressed: UNC-60A is found in oocytes, embryos, and the adult gonad and intestine, while UNC-60B is found in body wall muscle, the vulva, and spermatheca. Roy et al 2002 S2 positivecontrol L1 muscle, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C38D4.6 Aff_C38D4.6 ceh-3; nob-2; pal-1; C38D4.6; C38D4.6a.1; C38D4.6a.2; C38D4.6b.1; C38D4.6b.2; 3F896; CE05383; CE27837; NM_065590; WBGene00003912; WP:CE05383; WP:CE27837 pal-1 encodes a homeodomain protein that is the C. elegans Caudal ortholog; PAL-1 is required maternally and embryonically for cell fate specification and posterior patterning during embryogenesis; PAL-1 is also required postembryonically for fate specification of the posterior V6 neuroectoblast during male tail development; PAL-1 is expressed in posterior blastomeres beginning at the four-cell stage of embryogenesis and its expression continues during embryogenesis in posterior-derived tissues and cells undergoing movement or forming midline structures; pal-1 is subject to both transcriptional and translational regulation. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E C39F7.4 Aff_C39F7.4 rab-1; C39F7.4; C39F7.4.1; C39F7.4.2; 5B742; CE16905; NM_070996; WBGene00004266; WP:CE16905 rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline. RAS-related protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C44B7.2 Aff_C44B7.2 C44B7.2; C44B7.2a.1; C44B7.2a.2; CE25812; CE34752; WBGene00016624; WP:CE25812; WP:CE34752 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C45B2.5 Aff_C45B2.5 gln-1; C45B2.5; C45B2.5.1; C45B2.5.2; CE27854; NM_076611; WBGene00001602; WP:CE27854; XG677 Glutamine synthetase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated C46C2.1 Aff_C46C2.1 wnk-1; C46C2.1; 4J975; CE37331; CE37332; NM_069202; NM_182275; WBGene00006941; WP:CE37331; WP:CE37332 wnk-1 is orthologous to the human gene PROTEIN KINASE, LYSINE-DEFICIENT 1 (PRKWNK1; OMIM:605232), which when mutated leads to pseudohypoaldosteronism type II. serine/threonine kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C47G2.2 Aff_C47G2.2 unc-130; C47G2.2; 2L573; CE02166; NM_064010; WBGene00006853; WP:CE02166 A member of the forkhead domain family of transcription factors that affects the generation of the AWA and ASG chemosensory neurons and is partially required for male tail morphogenesis and embryogenesis; it is expressed in the AWA and ASG precursors; it is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor. fork head domain protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C50F2.6 Aff_C50F2.6 dao-8; fkb-5; C50F2.6; C50F2.6a.1; C50F2.6a.2; 1E466; CE08912; CE27878; NM_058856; NM_058857; WBGene00001430; WP:CE08912; WP:CE27878 fkb-5 encodes a homolog of human FK506 binding protein 9. Link et al 2003 T2 Abeta repressed, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C52B11.2 Aff_C52B11.2 tag-303; C52B11.2; CE04258; WBGene00016871; WP:CE04258; XB927 potassium channel protein Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit C56A3.6 Aff_C56A3.6 C56A3.6; 5O34; CE32339; WBGene00008345; WP:CE32339 EF hand (2 domains) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated D1025.2 Aff_D1025.2 D1025.2; CE17610; WBGene00008354; WP:CE17610; XP132 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 D1044.6 Aff_D1044.6 D1044.6; 3G626; CE32173; WBGene00017031; WP:CE32173 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen D2013.6 Aff_D2013.6 D2013.6; 2J621; CE00931; WBGene00008404; WP:CE00931 ViswanathanM et al 2005 S2 sir-2.1 regulated D2023.5 Aff_D2023.5 D2023.5; 5M306; CE09075; WBGene00008409; WP:CE09075 thiosulphate sulphurtransferase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA D2030.5 Aff_D2030.5 mce-1; D2030.5; 1I159; CE09082; WBGene00008415; WP:CE09082 B.subtilis YQJC protein like ViswanathanM et al 2005 S2 sir-2.1 regulated D2045.9 Aff_D2045.9 D2045.9; CE33988; WBGene00008426; WP:CE33988 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 E04A4.1 Aff_E04A4.1 fbxb-78; E04A4.1; 4F501; CE32346; WBGene00017116; WP:CE32346 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated F01F1.8 Aff_F01F1.8 cct-6; F01F1.8; F01F1.8a.1; F01F1.8a.2; F01F1.8b.1; F01F1.8b.2; F01F1.8b.3; 3G944; CE01234; CE30647; NM_171135; NM_171136; WBGene00000381; WP:CE01234; WP:CE30647 eukaryotic cytosolic chaperonin; affects viability and fertility, and is expressed in various muscle and neuronal cells: near the pharynx, near the anal sphincter, in the ventral nerve cord and the nerve ring; occasionally the expression is visible in hypodermal cells and in some vulval cells. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F02E9.7 Aff_F02E9.7 F02E9.7; 1I991; CE09190; WBGene00008531; WP:CE09190 acid phosphatase Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08F1.7 Aff_F08F1.7 tag-123; F08F1.7; CE09254; WBGene00006472; WP:CE09254; XJ38 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated F08G12.3 Aff_F08G12.3 F08G12.3; CE03168; WBGene00008587; WP:CE03168; XL921 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma F09C3.5 Aff_F09C3.3 fbxb-69; F09C3.5; 1O872; CE24886; WBGene00008613; WP:CE24886 F09F7.4 Aff_F09F7.4 F09F7.4; F09F7.4a.1; F09F7.4a.2; F09F7.4b.1; F09F7.4b.2; F09F7.4b.3; 3G645; CE00689; CE30654; WBGene00017301; WP:CE00689; WP:CE30654 Enoyl-CoA hydratase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F09G2.2 Aff_F09G2.2 F09G2.2; 5H677; CE37626; WBGene00017311; WP:CE37626 ViswanathanM et al 2005 S2 sir-2.1 regulated F09G8.3 Aff_F09G8.3 F09G8.3; 3J357; CE24890; WBGene00017319; WP:CE24890 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F10B5.7 Aff_F10B5.7 rrf-3; F10B5.7; 2I457; CE02178; NM_063312; WBGene00004510; WP:CE02178 rrf-3 encodes an RNA-directed RNA polymerase (RdRP) homolog that inhibits somatic RNAi, and thus promotes activity of repeated genes (e.g., multicopy transgenic arrays); the effect of RRF-3 on RNAi is opposite to that of RRF-1 (which stimulates somatic RNAi), which might arise from competition by RRF-3 with RRF-1 or EGO-1 in RNAi formation; rrf-3(allele) or rrf-3(allele2) mutants are hypersensitive to somatic RNAi, and conversely suppress the activity of an integrated rol6 (su1006) transgene. Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Metabolism F10C2.5 Aff_F10C2.5 F10C2.5; CE09309; NM_073617; WBGene00008646; WP:CE09309 mannosyl-oligosaccharide alpha-1,2-mannosidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Romagnolo et al 2002 Fig3b Adhesion F10D7.2 Aff_F10D7.2 F10D7.2; F10D7.2.1; F10D7.2.2; CE04352; WBGene00017339; WP:CE04352; XR980 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. calcium alpha subunit; tetracycline resistance Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig3b Transporters, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F11A3.2 Aff_F11A3.2 F11A3.2; 5J997; CE05586; CE38501; WBGene00008670; WP:CE05586; WP:CE38501 guanine nucleotide exchange factor Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F11C1.1 Aff_F11C1.1 F11C1.1; CE03186; WBGene00008690; WP:CE03186; XN606 Jones et al 2001 Dauer specific genes P<0.05, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F11E6.1 Aff_F11E6.1 F11E6.1; 4S421; CE20669; CE26698; CE31166; WBGene00008706; WP:CE20669; WP:CE26698; WP:CE31166 F11E6.1 is homologous to to the human gene GLUCOCEREBROSIDASE (GBA; OMIM:606463), which when mutated leads to Gaucher disease. Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, IVb male soma enriched genes, Reinke et al 2004, mixed sperm soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 F11G11.7 Aff_F11G11.7 dnj-9; F11G11.7; 2F149; CE07060; NM_062471; WBGene00001027; WP:CE07060 This gene encodes a protein containing a DnaJ ('J') domain. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F12F6.6 Aff_F12F6.6 sec-24.1; F12F6.6; 4M328; CE05594; NM_069777; WBGene00004755; WP:CE05594 sec-24.1 encodes one of two C. elegans Sec24 homologs; in Saccharomyces cerevisiae, Sec24 is a member of the Sec24-Sec23 subunit of the COPII coat complex, assembly of which is essential for the first step of secretory protein transport from the endoplasmic reticulum (ER) to the Golgi; by homology with Sec24, SEC-24.1 is predicted to facilitate vesicle cargo selection, and likely contains multiple, independent sites for binding to secreted proteins; loss of sec-24.1 activity via RNAi indicates that SEC-24.1 is required for cuticle secretion and oogenesis. Yeast hypothetical YIK9 protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F13D12.4 Aff_F13D12.4 alh-8; F13D12.4; F13D12.4a.1; F13D12.4a.2; F13D12.4a.3; F13D12.4a.4; 2M21; CE02183; CE36262; WBGene00000114; WP:CE02183; WP:CE36262 alh-8 is orthologous to the human gene METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (ALDH6A1; OMIM:603178), which when mutated leads to MMSDH deficiency. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F13G3.11 Aff_F13G3.7 F13G3.11; F13G3.11.1; F13G3.11.2; 1H885; CE28913; WBGene00008769; WP:CE28913 F13H10.4 Aff_F13H10.4 F13H10.4; 4L782; CE05625; WBGene00008775; WP:CE05625 F13H10.4 is orthologous to the human gene A-GLUCOSIDASE I (GCS1; OMIM:601336), which when mutated leads to disease. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F14F3.2 Aff_F14F3.2 F14F3.2; CE31478; WBGene00008805; WP:CE31478; XL145 ankyrin motif McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F18C5.10 Aff_F18C5.4 F18C5.10; F18C5.10.1; F18C5.10.2; 2G850; CE31790; WBGene00017563; WP:CE31790 F19H8.1 Aff_F19H8.1 tps-2; F19H8.1; CE37507; NM_064634; WBGene00006603; WP:CE37507 tps-2 encodes one of two trehalose-6-phosphate synthase proteins in C. elegans, and RNAi of both enzymes leads to a more than 90% reduction decrease in trehalose levels, but does not appear to affect viability or development; the tps-2 mRNA is expressed throughout development. trehalose phosphate synthase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan F20B6.2 Aff_F20B6.2 vha-12; F20B6.2; F20B6.2.1; F20B6.2.2; CE04424; NM_076310; WBGene00006921; WP:CE04424; XE811 vacuolar ATP synthase (strong) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F20D1.3 Aff_F20D1.3 F20D1.3; F20D1.3.1; F20D1.3.2; CE31486; WBGene00008975; WP:CE31486; XP595 F21G4.2 Aff_F21G4.2 mrp-4; F21G4.2; CE09548; NM_077257; WBGene00003410; WP:CE09548; XK507 The mrp-4 gene encodes a homolog of human CFTR, which when mutated leads to cystic fibrosis (OMIM:219700). multidrug resistance-associated protein Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F23F1.3 Aff_F23F1.3 F23F1.3; 2A323; CE31795; WBGene00017744; WP:CE31795 ViswanathanM et al 2005 S2 sir-2.1 regulated F25B4.8 Aff_F25B4.8 F25B4.8; 5G170; CE30761; CE30762; WBGene00017771; WP:CE30761; WP:CE30762 ViswanathanM et al 2005 S2 sir-2.1 regulated F25H5.6 Aff_F25H5.6 F25H5.6; F25H5.6.1; F25H5.6.2; 1J734; CE29591; WBGene00009128; WP:CE29591 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F26B1.2 Aff_F26B1.2 F26B1.2; F26B1.2c.1; F26B1.2c.2; F26B1.2c.3; 1G895; CE09674; CE33057; CE33058; CE33059; CE33060; WBGene00017816; WP:CE09674; WP:CE33057; WP:CE33058; WP:CE33059; WP:CE33060 RNA-binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F26D11.11 Aff_F26D11.11 let-413; F26D11.11; 5I454; CE29778; CE37008; NM_072650; WBGene00002632; WP:CE29778; WP:CE37008 let-413 encodes a protein with strong similarity to human ERBIN, rat DENSIN, Drosophila SCRIB and its human ortholog hSCRIB; LET-413 protein is localized to the basolateral region of epithelial cells, and is required for the assembly of adherens junctions. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F27D4.2 Aff_F27D4.2 F27D4.2; F27D4.2.1; F27D4.2.2; F27D4.2.3; F27D4.2.4; 1I282; CE36140; WBGene00009188; WP:CE36140 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F27D4.5 Aff_F27D4.5 tag-173; F27D4.5; F27D4.5.1; F27D4.5.2; 1I305; CE05736; WBGene00006518; WP:CE05736 tag-173/F27D4.5 is orthologous to the human gene BRANCHED CHAIN KETO ACID DEHYDROGENASE E1, ALPHA POLYPEPTIDE (BCKDHB; OMIM:248600), which when mutated leads to maple syrup urine disease, type 1a; F27D4.5 protein is predicted to be mitochondrial. 2-oxoisovalerate dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F27E5.2 Aff_F27E5.2 pax-3; F27E5.2; 2K439; CE35862; NM_063788; WBGene00003939; WP:CE35862 pax-3 encodes a divergent paired-like homeodomain protein that does not belong to the Q50, K50, or S50 classes; PAX-3 is required for locomotion and vulval development; pax-3(RNAi) animals have consistent Pvl and Unc phenotypes (as well as less consistent Bmd, Rup, and Stp phenotypes). 'Paired box' domain, homeobox protein (paired subfamily) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F28B3.1 Aff_F28B3.1 F28B3.1; 1F517; CE36644; WBGene00017882; WP:CE36644 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F28D1.10 Aff_F28D1.10 gex-3; F28D1.10; 4N171; CE05750; NM_069967; WBGene00001580; WP:CE05750 The gex-3 gene encodes a homolog of NAP1/NCKAP1, a mammalian protein ligand of the small GTPase Rac1, and of Drosophila HEM2/NAP1/KETTE; gex-3 is required for tissue morphogenesis and cell migrations; in gex-3 mutants, cells differentiate properly but fail to become organized. Drosophila dhem transmembrane protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F29F11.6 Aff_F29F11.6 CEGLC-7A; Ce-glc-7alpha; glc-7; gsp-1; F29F11.6; F29F11.6.1; F29F11.6.2; F29F11.6.3; F29F11.6.4; 5L165; CE20735; NM_073332; WBGene00001747; WP:CE20735 serine/threonine protein phosphatase ViswanathanM et al 2005 S2 sir-2.1 regulated F30A10.10 Aff_F30A10.10 F30A10.10; 1K87; CE32639; WBGene00009267; WP:CE32639 ubiquitin carboxyl-termianl hydrolase Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F30A10.6 Aff_F30A10.6 F30A10.6; 1K67; CE09807; WBGene00009264; WP:CE09807 Yeast recessive suppressor RSD1 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F32A5.6 Aff_F32A5.6 prx-13; F32A5.6; 2H540; CE28290; NM_063112; WBGene00004198; WP:CE28290 prx-13 is orthologous to the human gene PEX13 (OMIM:601789), which when mutated leads to Zellweger syndrome or neonatal adrenoleukodystrophy. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F32B6.1 Aff_F32B6.1 nhr-4; F32B6.1; F32B6.1.1; F32B6.1.2; 4K645; CE24934; NM_069374; WBGene00003603; WP:CE24934 nhr-4 is predicted to encode a nuclear hormone receptor (NHR); expression may peak during the late larval stages, based on mRNA expression analysis. Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F33A8.3 Aff_F33A8.3 cey-1; F33A8.3; F33A8.3.1; F33A8.3.2; 2L330; CE17755; NM_063965; WBGene00000472; WP:CE17755 cey-1 encodes a protein with a cold-shock/Y-box domain that is expressed in early embryonic blastomeres (at the 15-cell stage, i.e., pre-gastrulation), but is normally repressed in early germline blastomeres by PIE-1; it is predicted to be mitochondrial by phylogenetic profiling. 'Cold-shock' DNA-binding domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F33H2.1 Aff_F33H2.1 dog-1; F33H2.1; 1P610; CE17764; NM_061217; WBGene00001049; WP:CE17764 dog-1 encodes a predicted DEAH helicase, orthologous to the human BRCA1-binding protein BACH1 (OMIM:605882, mutated in early-onset breast cancer); DOG-1 is required for maintenance of polyguanine tracts of germline and somatic DNA, and is proposed to resolve the secondary structure that can occur in guanine-rich DNA during lagging-strand DNA synthesis. Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F35D2.3 Aff_F35D2.3 F35D2.3; 2H861; CE31804; WBGene00018041; WP:CE31804 Baugh et al 2005, PAL-1 target genes, Jones et al 2001 Non dauer genes P<0.05 F35G12.12 Aff_F35G12.12 F35G12.12; F35G12.12.1; F35G12.12.2; 3F673; CE31499; WBGene00009445; WP:CE31499 Lund et al 2002 Fig3C Germline-intrinsic, Lund et al 2002 Fig1 aging-regulated genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F36H2.1 Aff_F36H2.1 tat-5; F36H2.1; 1J812; CE34183; CE34184; CE39367; WBGene00009498; WP:CE34183; WP:CE34184; WP:CE39367 E1-E2 ATPase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F37C12.2 Aff_F37C12.2 F37C12.2; 3I275; CE00741; WBGene00018150; WP:CE00741 Link et al 2003 T2 Abeta induced, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F37C12.7 Aff_F37C12.7 F37C12.7; 3I259; CE29312; WBGene00018152; WP:CE29312 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F38A5.2 Aff_F38A5.2 F38A5.2; F38A5.2b.1; F38A5.2b.2; CE34010; CE34011; WBGene00018161; WP:CE34010; WP:CE34011 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F38E9.5 Aff_F38E9.5 F38E9.5; F38E9.5.1; F38E9.5.2; CE28307; WBGene00018187; WP:CE28307; XR65 protein tyrosine kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C F38H4.9 Aff_F38H4.9 PP2A-C; let-92; F38H4.9; F38H4.9.1; F38H4.9.2; 4M623; CE10074; NM_069846; WBGene00002363; WP:CE10074 let-92 encodes a homolog of PP2AC, the catalytic subunit of protein phosphatase 2A (PP2A), identified genetically in screens for essential genes on chromosome IV; LET-92 may regulate a number of signal transduction pathways as it is required for embryogenesis, larval development, Ras-mediated vulval development, and axonal guidance in the DD and VD neurons; let-92 interacts genetically with sur-6 which encodes a regulatory subunit of PP2A; LET-92 protein is bound both by SMG-2 and by POS-1, and also interacts in vitro with UNC-51 and UNC-14; LET-92 is expressed cytoplasmically in nearly all cells and strongly in many neurons. serine/threonine protein phosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F39H11.3 Aff_F39H11.3 cdk-8; F39H11.3; 1J281; CE32409; NM_059956; WBGene00000409; WP:CE32409 cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development. serine/threonine kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F40F11.2 Aff_F40F11.2 F40F11.2; 4M365; CE28557; WBGene00009587; WP:CE28557 ViswanathanM et al 2005 S2 sir-2.1 regulated F40F9.7 Aff_F40F9.7 F40F9.7; F40F9.7a.1; F40F9.7a.2; F40F9.7b.1; F40F9.7b.2; F40F9.7b.3; F40F9.7b.4; 5K213; CE05856; CE33580; WBGene00009584; WP:CE05856; WP:CE33580 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F41E6.6 Aff_F41E6.6 tag-196; F41E6.6; F41E6.6.1; F41E6.6.2; 5J77; CE35305; WBGene00007055; WBGene00018287; WP:CE35305 cysteine protease and a protease inhibitor Kwon et al 2004 T1 late-induction Ethanol-response, Lund et al 2002 Fig1 aging-regulated genes, Lund et al 2002 Fig4 Mount 15, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F41H10.3 Aff_F41H10.3 F41H10.3; 4G139; CE10276; CE31694; WBGene00018316; WP:CE10276; WP:CE31694 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F42G9.4 Aff_F42G9.4 F42G9.4; 3B379; CE30789; WBGene00018363; WP:CE30789 Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F42H10.7 Aff_F42H10.7 F42H10.7; 3J578; CE00169; CE37109; WBGene00018371; WP:CE00169; WP:CE37109 Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F44B9.3 Aff_F44B9.3 cit-1.2; F44B9.3; 3J103; CE29042; CE32417; NM_066344; NM_181926; WBGene00000508; WP:CE29042; WP:CE32417 cit-1.2 encodes one of two C. elegans cyclin T orthologs; RNAi experiments indicate that CIT-1.2 functions redundantly with CIT-1.1 to broadly regulate embryonic transcription; by homology, CIT-1.1 and CIT-1.2 are predicted to interact with the CDK-9 kinase to form the P-TEFb transcription elongation factor that in C. elegans is required for Ser2, but not Ser5, phosphorylation in the C-terminal domain (CTD) repeat of AMA-1/PolII. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F44E2.8 Aff_F44E2.8 F44E2.8; 3J938; CE32420; WBGene00018421; WP:CE32420 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F46C5.9 Aff_F46C5.9 F46C5.9; 2J100; CE10584; WBGene00009784; WP:CE10584 G-protein ViswanathanM et al 2005 S2 sir-2.1 regulated F46C8.3 Aff_F46C8.3 F46C8.3; CE28334; WBGene00018485; WP:CE28334; XI145 ViswanathanM et al 2005 S2 sir-2.1 regulated F47G4.2 Aff_F47G4.2 F47G4.2; 1O670; CE19875; WBGene00009823; WP:CE19875 Leucine Rich Repeat (2 copies) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma F48C1.6 Aff_F48C1.6 F48C1.6; 1F886; CE10742; WBGene00018599; WP:CE10742 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F49D11.9 Aff_F49D11.9 tag-296; F49D11.9; 1L520; CE17083; CE33286; WBGene00018632; WP:CE17083; WP:CE33286 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F52B11.5 Aff_F52B11.5 F52B11.5; 4O866; CE18725; WBGene00009927; WP:CE18725 F52D10.2 Aff_F52D10.2 F52D10.2; CE03388; WBGene00009930; WP:CE03388; XM208 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F52D10.3 Aff_F52D10.3 ftt-2; F52D10.3; F52D10.3a.1; F52D10.3a.2; F52D10.3b.1; F52D10.3b.2; CE03389; CE36489; NM_077537; NM_077538; WBGene00001502; WP:CE03389; WP:CE36489; XM222 14-3-3 protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, IVb male soma enriched genes F52E4.7 Aff_F52E4.7 F52E4.7; CE10836; WBGene00018703; WP:CE10836; XD714 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F53B3.5 Aff_F53B3.5 F53B3.5; CE30142; WBGene00018743; WP:CE30142; XD492 F53B3.5 encodes a claudin homolog that may regulate ion channels; F53B3.5 is distantly similar to mammalian voltage-dependent calcium channel gamma subunits that are known or suspected to prevent epilepsy in vivo (e.g., stargazin; MGI:1316660); F53B3.5 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F54B11.3 Aff_F54B11.3 unc-84; F54B11.3; CE27761; CE28236; WBGene00006816; WP:CE27761; WP:CE28236; XO207 unc-84 encodes a transmembrane protein that contains a SUN domain with homology to S. pombe Sad1 and affects nuclear migration and anchoring of various cell types together with UNC-83 and ANC-1, thereby affecting coordinated locomotion, vulval formation, and egg laying; UNC-84 is localized to the nuclear envelope and requires LMN-1 for this localization, and it is expressed in the nuclear envelope of essentially all adult and embryonic cells. ViswanathanM et al 2005 S2 sir-2.1 regulated F54D11.2 Aff_F54D11.2 F54D11.2; F54D11.2.1; F54D11.2.2; F54D11.2.3; 5F105; CE30805; WBGene00018812; WP:CE30805 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol F54D5.8 Aff_F54D5.8 dnj-13; F54D5.8; 2L839; CE03412; NM_064067; WBGene00001031; WP:CE03412 This gene encodes a protein containing a DnaJ ('J') domain. DNAJ protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F54F3.4 Aff_F54F3.4 F54F3.4; 5N403; CE19894; WBGene00010063; WP:CE19894 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. dehydrogenase Wang et al 2003 S6 removed genes of contamination F54H12.3 Aff_F54H12.3 F54H12.3; 3J48; CE00545; WBGene00018843; WP:CE00545 ViswanathanM et al 2005 S2 sir-2.1 regulated F55A12.2 Aff_F55A12.2 F55A12.2; F55A12.2d.1; F55A12.2d.2; 1F933; CE29396; CE30540; CE34317; CE34318; WBGene00018863; WP:CE29396; WP:CE30540; WP:CE34317; WP:CE34318 ViswanathanM et al 2005 S2 sir-2.1 regulated F55F8.3 Aff_F55F8.3 F55F8.3; 1G218; CE30542; WBGene00018891; WP:CE30542 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F55H2.2 Aff_F55H2.2 vha-14; F55H2.2; F55H2.2.1; F55H2.2.2; 3K599; CE00209; NM_066693; WBGene00010130; WP:CE00209 Membrane-associated atpase gamma chain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56D2.2 Aff_F56D2.2 F56D2.2; 3G677; CE11228; WBGene00018964; WP:CE11228 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F56H9.5 Aff_F56H9.5 lin-25; F56H9.5; 5N137; CE05975; NM_073761; WBGene00003011; WP:CE05975 lin-25 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F57B9.2 Aff_F57B9.2 ntl-1; F57B9.2; 3I47; CE01337; NM_066115; WBGene00003824; WP:CE01337 Lund et al 2002 Fig1 aging-regulated genes, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol F57B9.7 Aff_T07E3.7 F57B9.7; 3I14; CE31011; CE31012; WBGene00018998; WP:CE31011; WP:CE31012 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F57G12.1 Aff_F57G12.1 F57G12.1; F57G12.1.1; F57G12.1.2; CE03426; WBGene00010221; WP:CE03426; XM788 Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F58F9.7 Aff_F58F9.7 F58F9.7; F58F9.7.1; F58F9.7.2; 4H10; CE07304; WBGene00019060; WP:CE07304 acyl-coenzyme A oxidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F58G11.2 Aff_F58G11.2 F58G11.2; 5O149; CE11402; WBGene00010280; WP:CE11402 ATP-dependent RNA helicase like ViswanathanM et al 2005 S2 sir-2.1 regulated F58G11.6 Aff_F58G11.6 F58G11.6; 5O161; CE11410; WBGene00010283; WP:CE11410 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F58H1.1 Aff_F58H1.1 F58H1.1; 5M408; CE06025; CE39509; WBGene00010284; WP:CE06025; WP:CE39509 alpha-mannosidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F58H7.7 Aff_F58H7.7 F58H7.7; 4B667; CE34326; WBGene00019072; WP:CE34326 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. H12C20.2 Aff_F38B7.7 pms-2; H12C20.2; 5M48; CE18807; CE19915; NM_073532; NM_073533; WBGene00004064; WP:CE18807; WP:CE19915 DNA mismatch repair protein (PMS2) Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen H20J04.6 Aff_H20J04_717.A H20J04.6; H20J04.B; 2E613; CE20973; WBGene00019221; WP:CE20973 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K01A6.2 Aff_K01A6.1 magi-1; K01A6.2; 4M493; CE37387; WBGene00010444; WP:CE37387 membrane-associated guanylate kinase homolog (MAGUK) Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 daf-16 Resveratrol K01G5.1 Aff_K01G5.1 tag-331; K01G5.1; 3K846; 3L846; CE26718; WBGene00010476; WP:CE26718 Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E K02D10.1 Aff_K02D10.1 K02D10.1; K02D10.1b.1; K02D10.1b.2; 3J865; CE17151; CE29423; WBGene00019301; WP:CE17151; WP:CE29423 4-NITROPHENYLPHOSPHATASE McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K02D3.1 Aff_K02D3.1 K02D3.1; CE06069; WBGene00010504; WP:CE06069; XO323 K02G10.8 Aff_K02G10.8 dnj-14; K02G10.8; CE04708; NM_076405; WBGene00001032; WP:CE04708; XF330 This gene encodes a protein containing a DnaJ ('J') domain. Lund et al 2002 Fig3B neuro-specific genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K03D10.1 Aff_K03D10.1 kal-1; K03D10.1; 1O722; CE35892; NM_061067; WBGene00002181; WP:CE35892 kal-1 encodes a cell surface protein that contains a WAP-type protease inhibitor domain and Type III fibronectin domains and is the C. elegans ortholog of human KAL-1, mutated in the X-linked form of the neurological disorder Kallmann syndrome; in C. elegans, both kal-1 loss-of-function mutations and kal-1 overexpression result in similar phenotypes that indicate KAL-1 activity is required for epithelial morphogenesis and axon branching; kal-1 transcriptional reporters reveal expression beginning in the 50-cell stage embryo in 2-3 cells with later embryonic expression in at least 8-10 AB-derived ventral neuroblasts that are a substrate for migrating epidermal cells during ventral enclosure; later expression in larvae and adults is restricted to anterior neurons, including AIY, AIZ, RID, M5, ASI, and labial sensory neurons, ventral nerve cord motorneurons, midbody neurons HSN, CAN, and PVM, tail neurons DVB, DVC, and PDB, and the nonneuronal excretory cell as well as in uterine muscles; in the AIY interneurons, kal-1 is part of a gene battery whose expression is under the control of the CEH-10 and TTX-3 Paired and LIM-type homeodomains, respectively. WAP-type (Whey Acidic Protein) 'four-disulfide core', Fibronectin type III domain (3 domains) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol K04G2.6 Aff_K04G2.6 K04G2.6; K04G2.6.1; K04G2.6.2; 1I619; CE06100; WBGene00010565; WP:CE06100 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K05C4.2 Aff_K05C4.2 K05C4.2; K05C4.2.1; K05C4.2.2; 1P312; CE19970; WBGene00010579; WP:CE19970 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K07B1.5 Aff_K07B1.5 acl-14; K07B1.5; K07B1.5a.1; K07B1.5a.2; 5J808; CE29507; CE30091; NM_073010; NM_073011; WBGene00019465; WP:CE29507; WP:CE30091 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K07C5.1 Aff_K07C5.1 arx-2; K07C5.1; 5K816; CE06111; NM_073256; WBGene00000200; WP:CE06111 actin McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated K08D10.4 Aff_K08D10.4 rnp-2; K08D10.4; 4E937; CE28597; NM_068103; WBGene00004385; WP:CE28597 U1 small nuclear ribonucleoprotein A Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K08F4.2 Aff_K08F4.2 K08F4.2; 4K892; CE37535; WBGene00010677; WP:CE37535 RNA recognition motif. (aka RRM, RBD, or RNP domain) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated K08H2.6 Aff_K08H2.6 hpl-1; K08H2.6; CE06164; NM_077798; WBGene00001995; WP:CE06164; XN865 The hpl-1 gene encodes a homolog of heterochromatin protein 1 (HP1) that acts to support the activity of HPL-2 in promoting germline function, but that by itself is dispensable for any obvious function in vivo. murine modifier 2 protein like ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K09A9.1 Aff_K09A9.1 K09A9.1; CE33670; WBGene00010700; WP:CE33670; XQ229 serine/threonine kinase Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order K09A9.2 Aff_K09A9.2 rab-14; K09A9.2; K09A9.2.1; K09A9.2.2; CE11974; NM_078171; WBGene00004276; WP:CE11974; XQ224 rab-14 encodes a member of the Rab GTPase family. RAS-related protein Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated K09H9.7 Aff_K09H9.7 K09H9.7; 1D718; CE39596; WBGene00019598; WP:CE39596 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated K10B3.5 Aff_K10B3.5 K10B3.5; CE07368; WBGene00019611; WP:CE07368; XD722 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K11H3.1 Aff_K11H3.1 K11H3.1; K11H3.1b.1; K11H3.1b.2; 3K944; CE31850; CE31851; WBGene00010778; WP:CE31850; WP:CE31851 K11H3.1 encodes one of two C. elegans glycerol 3-phosphate dehydrogenases; although loss of K11H3.1 activity via large-scale RNAi screens results in no obvious defects, expression of a K11H3.1 cDNA in Saccharomyces cerevisiae hog1 mutants is able to rescue the high osmolarity-sensitive growth phenotype of these mutants, suggesting that K11H3.1 encodes a functional glycerol 3-phosphate dehydrogenase. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K12F2.2 Aff_K12F2.2 klp-5; unc-107; vab-8; K12F2.2; 5M705; CE23870; CE31041; NM_073662; NM_073663; WBGene00006874; WP:CE23870; WP:CE31041 The vab-8 gene encodes a novel protein containing an atypical kinesin-like motor domain that is required for many posteriorly-directed cell migrations, as well as axonal outgrowth and pathfinding; vab-8 encodes two protein isoforms: VAB-8S, a novel protein expressed in migrating cells, and VAB-8L, which contains a kinesin-related domain, is expressed in neurons and functions in growth cone migrations; VAB-8 interacts with UNC-51, a serine-threonine kinase also required for axon outgrowth. kinesin-like protein M01B2.10 Aff_M01B2.10 M01B2.10; 5P742; CE16271; WBGene00010803; WP:CE16271 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol M02A10.3 Aff_M02A10.3 sli-1; M02A10.3; CE25058; CE27393; CE37131; NM_075744; WBGene00004829; WP:CE25058; WP:CE27393; WP:CE37131; XB340 adaptor-like E3 ubiquitin ligase ViswanathanM et al 2005 S2 sir-2.1 regulated M03F4.7 Aff_M03F4.7 M03F4.7; CE12368; CE34060; WBGene00019760; WP:CE12368; WP:CE34060; XF588 calcium binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Zhang et al 2002, T1 mec-3 dependent genes M88.6 Aff_M88.6 pan-1; M88.6; 3F655; CE01041; CE23886; NM_065523; NM_065524; WBGene00003915; WP:CE01041; WP:CE23886 Leucine-rich repeats ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 PAR2.1 Aff_PAR2.1 PAR2.1; PAR2.1.1; PAR2.1.2; 3J859; CE00768; WBGene00019800; WP:CE00768 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R02E12.6 Aff_R02E12.6 R02E12.6; R02E12.6.1; R02E12.6.2; CE30099; WBGene00019830; WP:CE30099; XE628 Jones et al 2001 Dauer specific genes P<0.05, Jones et al 2001 T3 20 most abundant Dauer, Wang et al 2003 S8 SAGE genes in the dauer exit R03A10.4 Aff_R03A10.4 R03A10.4; R03A10.4a.1; R03A10.4a.2; R03A10.4b.1; R03A10.4b.2; CE29335; CE37983; WBGene00010984; WP:CE29335; WP:CE37983; XQ61 gluamine-phenylpyruvate transaminase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated R06C7.5 Aff_R06C7.5 R06C7.5; R06C7.5b.1; R06C7.5b.2; 1H824; CE06248; CE32476; WBGene00011064; WP:CE06248; WP:CE32476 The R06C7.5 gene encodes an ortholog of the human gene ADSL, which when mutated leads to adenylosuccinate lyase deficiency (OMIM:103050). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated R06F6.6 Aff_R06F6.6 R06F6.6; 2L101; CE01622; WBGene00011069; WP:CE01622 Homeobox domain ViswanathanM et al 2005 S2 daf-16 Resveratrol R07E4.4 Aff_R07E4.4 mig-23; R07E4.4; R07E4.4.1; R07E4.4.2; CE28748; NM_076593; WBGene00003254; WP:CE28748; XG566 guanosine-diphosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated R07E5.7 Aff_R07E5.7 R07E5.7; R07E5.7.1; R07E5.7.2; 3F510; CE00672; WBGene00011115; WP:CE00672 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R08B4.2 Aff_R08B4.2 alr-1; sns-10; R08B4.2; CE03536; WBGene00011138; WBGene00044330; WP:CE03536; XL742 homeobox protein (otd subfamily) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol R08E3.4 Aff_R08E3.4 R08E3.4; CE37662; CE37663; WBGene00019960; WP:CE37662; WP:CE37663; XF426 C2H2-type zinc finger McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol R10E11.1 Aff_R10E11.1 cbp-1; cep-1; R10E11.1; 3K863; CE21117; CE28069; NM_066759; NM_066760; WBGene00000366; WP:CE21117; WP:CE28069 cbp-1 encodes a homolog of the mammalian transcriptional cofactors CBP (OMIM:600140) and p300 (E1A-BINDING PROTEIN, 300-KD; OMIM:602700) that have been shown to possess histone acetyltransferase activity, and which, when mutated, lead to Rubinstein-Taybi syndrome (OMIM:180849) and colorectal cancer (OMIM:114500); at least one splicing form of CBP-1 exhibits histone acetyltransferase (HAT) activity in vitro and has a glutamine/asparagine-rich domain; CBP-1 is required during embryogenesis for differentiation of all non-neuronal somatic cell types; CBP-1 is expressed very early in embryogenesis, suggesting that it may interact with maternally provided transcription factors, such as SKN-1, to specific developmental fates. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph R10E11.8 Aff_R10E11.8 vha-1; R10E11.8; R10E11.8.1; R10E11.8.2; R10E11.8.3; 3K871; CE06291; NM_066764; WBGene00006910; WP:CE06291 vha-1 encodes a 16-kDa proteolipid of the vacuolar-type H+-ATPase (V-ATPase) and is required for embryogenesis and for oocyte ovulation, based on RNAi analysis; expressed in the excretory cells and the rectum of adult animals as well as in a pair of cells posterior to the anus. ATP synthase subunit C (2 domains) Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C R11E3.8 Aff_R11E3.8 dpf-5; R11E3.8; R11E3.8.1; R11E3.8.2; R11E3.8.3; 4F568; CE29985; NM_068246; WBGene00001058; WP:CE29985 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated R12C12.1 Aff_R12C12.1 R12C12.1; R12C12.1a.1; R12C12.1a.2; 2G343; CE02846; CE33434; WBGene00020022; WP:CE02846; WP:CE33434 R12C12.1 is orthologous to human GLYCINE DECARBOXYLASE (GLDC; OMIM:238300), which when mutated leads to glycine encephalopathy. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 R57.1 Aff_R57.1 R57.1; R57.1b.1; R57.1b.2; R57.1c.1; R57.1c.2; R57.1c.3; CE12844; CE30114; CE37270; WBGene00020082; WP:CE12844; WP:CE30114; WP:CE37270; XA925 trans-membrane protein McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R74.6 Aff_R74.6 R74.6; 3F292; CE01059; WBGene00011280; WP:CE01059 DOM34 protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated T03D8.3 Aff_T03D8.3 sbt-1; T03D8.3; 5V298; CE18921; WBGene00011392; WP:CE18921 neuroendocrine protein 7B2 Jiang et al 2001 Fig1 male-enriched neuronal, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T03F1.1 Aff_T03F1.1 T03F1.1; 1E443; CE13096; WBGene00020184; WP:CE13096 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T03F1.3 Aff_T03F1.3 T03F1.3; 1E435; CE13100; WBGene00020185; WP:CE13100 T03F1.3 is orthologous to the human gene PHOSPHOGLYCERETE KINASE 1 (PGK1; OMIM:311800), which when mutated leads to hemolytic anemia and neurologic disturbances. phosphoglycerate kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 T04C10.2 Aff_T04C10.2 epn-1; T04C10.2; CE26820; CE26821; NM_078057; NM_078058; WBGene00001329; WP:CE26820; WP:CE26821; XP436 Yeast hypothetical protein L8167.6 like ViswanathanM et al 2005 S2 sir-2.1 regulated T05B4.2 Aff_T05B4.2 nhr-57; T05B4.2; 5E613; CE13195; NM_071752; WBGene00003647; WP:CE13195 zinc finger protein Jones et al 2001 Dauer specific genes P<0.05, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit T05E11.5 Aff_T05E11.5 imp-2; T05E11.5; 4L882; CE06364; NM_069678; WBGene00011481; WP:CE06364 Yeast YKK0 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T05H4.6 Aff_T05H4.6 phi-21; T05H4.6; T05H4.6.1; T05H4.6.2; T05H4.6.3; 5G915; CE13279; WBGene00020269; WP:CE13279 eukaryotic peptide chain release factor subunit 1 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T06E8.1 Aff_T06E8.1 acl-2; T06E8.1; 5K510; CE06378; NM_073177; WBGene00011543; WP:CE06378 T06E8.1 is orthologous to the human gene 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 2 (LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE, BETA) (AGPAT2; OMIM:603100), which when mutated leads to disease; T06E8.1 protein is predicted to be mitochondrial. 1-acyl-SN-glycerol-3-phophate acyltransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T07A5.2 Aff_T07A5.2 T07A5.2; 3L404; CE36501; WBGene00011555; WP:CE36501 YK10 homolog McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T07E3.5 Aff_T07E3.5 brc-2; T07E3.5; 3H990; CE32718; NM_066101; WBGene00020316; WP:CE32718 The T07E3.5 gene encodes a single BRC domain (in residues 12-109) that might promote double-stranded DNA break repair; eight tandem BRC domains are encoded by the central coding region of the human BRCA2 gene, which when mutated leads to early-onset breast cancer 2 or hereditary male breast cancer (OMIM:600185). Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T08D10.2 Aff_T08D10.2 T08D10.2; CE33174; WBGene00011615; WP:CE33174; XM569 T08D10.2 encodes an ortholog of the human histone demethylase LSD1 (KIAA0601), and a paralog of C. elegans SPR-5; similar histone demethylase homologs are found in human, mouse, Drosophila, fission yeast, and Arabidopsis; T08D10.2 is predicted to demethylate histone H3 lysine 4 residues and act as a transcriptional corepressor. corticosteroid-binding protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T08G11.4 Aff_T08G11.4 T08G11.4; T08G11.4.1; T08G11.4.2; 1J480; CE23958; WBGene00011631; WP:CE23958 McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen T09B4.10 Aff_T09B4.10 chn-1; tag-69; T09B4.10; T09B4.10.1; T09B4.10.2; 1G758; CE29991; NM_059380; WBGene00000500; WP:CE29991 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E T09B9.4 Aff_T09B9.4 T09B9.4; T09B9.4.1; T09B9.4.2; CE01652; WBGene00011645; WP:CE01652; XK390 T09B9.4 is orthologous to the human gene PUTATIVE CYTOSKELETAL PROTEIN (D10S170; OMIM:601985), which when mutated leads to disease. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T10C6.6 Aff_T10C6.6 T10C6.6; T10C6.6a.1; T10C6.6a.2; T10C6.6a.3; T10C6.6b.1; T10C6.6b.2; T10C6.6b.3; T10C6.6b.4; T10C6.6b.5; 5Q507; CE16381; CE23965; WBGene00011688; WP:CE16381; WP:CE23965 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ViswanathanM et al 2005 S2 sir-2.1 regulated T12B3.4 Aff_T12B3.A T12B3.4; 4I150; CE21179; WBGene00020447; WP:CE21179 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T12D8.2 Aff_T12D8.2 drr-2; T12D8.2; T12D8.2.1; T12D8.2.2; 3O734; CE16399; WBGene00011730; WP:CE16399 RNA recognition motif. (aka RRM, RBD, or RNP domain) Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T14F9.3 Aff_T14F9.3 T14F9.3; CE07499; WBGene00020509; WP:CE07499; XC843 T14F9.3 is orthologous to the human gene CERVICAL CANCER PROTO-ONCOGENE 7 (HEXB; OMIM:606873), which when mutated leads to disease. beta-hexosaminidase beta subunit McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T14F9.5 Aff_T14F9.5 hlh-7; lin-32; T14F9.5; CE33318; NM_076009; WBGene00003018; WP:CE33318; XC846 lin-32 encodes a basic helix-loop-helix transcription factor that is required for development of several types of neurons, including the touch receptor neurons and the male sensory ray neurons. hlh transcription factor ViswanathanM et al 2005 S2 sir-2.1 regulated T14G10.2 Aff_T14G10.2 pxf-1; ra-gef; T14G10.2; T14G10.2a.1; T14G10.2a.2; T14G10.2b.1; T14G10.2b.2; 4K930; CE28080; CE28081; PXF; WBGene00004254; WP:CE28080; WP:CE28081 cell division control protein 25 like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol T14G12.4 Aff_T14G12.4 fkh-2; T14G12.4; T14G12.4b.1; T14G12.4b.2; CE04965; CE29342; NM_076243; NM_076244; WBGene00001434; WP:CE04965; WP:CE29342; XE360 fkh-2 encodes one of 15 forkhead transcriptional regulators encoded by the C. elegans genome, and is homologous to Drosophila sloppy-paired (slp) and the vertebrate Brain Factor 1 (BF-1, OMIM:164874, expression is restricted to the central nervous system); by homology, FKH-2 is predicted to function as a transcription factor that regulates gene expression during development; while loss of fkh-2 activity via RNA-mediated interference (RNAi) results only in mild locomotion defects in L1 larvae, further RNAi experiments indicate that fkh-2 and pes-1, which encodes another C. elegans forkhead transcription factor, are required redundantly for completion of embryonic and larval development; fkh-2 expression, which partially overlaps that of pes-1, is detected in embryos in descendants of the D and AB founder cell lineages. Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit T16H12.5 Aff_T16H12.5 bath-43; T16H12.5; T16H12.5b.1; T16H12.5b.2; T16H12.5b.3; 3L182; CE00510; CE29054; WBGene00011815; WP:CE00510; WP:CE29054 The T16H12.5 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis. Kruppel-like zinc finger protein (outside zinc fingers) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Shen et al 2005 T1 hif-1indepen hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated T19A5.1 Aff_T19A5.1 T19A5.1; T19A5.1.1; T19A5.1.2; 5J441; CE07509; WBGene00020553; WP:CE07509 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T20D4.15 Aff_T20D4.15 T20D4.15; 5D868; CE13806; WBGene00020620; WP:CE13806 T21B10.1 Aff_T21B10.1 T21B10.1; 2J221; CE03683; WBGene00011883; WP:CE03683 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T21B6.1 Aff_T21B6.1 dgn-1; T21B6.1; T21B6.1.1; T21B6.1.2; CE03679; NM_077425; WBGene00000961; WP:CE03679; XL540 T21E3.3 Aff_T21E3.3 lrp-2; T21E3.3; 1E504; CE28688; NM_058869; WBGene00003072; WP:CE28688 EGF-like protein ViswanathanM et al 2005 S2 daf-16 Resveratrol T22H2.4 Aff_T22H2.4 T22H2.4; 1M288; CE14002; WBGene00011934; WP:CE14002 ViswanathanM et al 2005 S2 sir-2.1 regulated T23B12.3 Aff_T23B12.3 T23B12.3; 5I947; CE14030; WBGene00020718; WP:CE14030 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated T23C6.4 Aff_T23C6.4 T23C6.4; CE07529; WBGene00020726; WP:CE07529; XR762 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order T23D8.4 Aff_T23D8.4 eif-3.C; T23D8.4; T23D8.4.1; T23D8.4.2; 1K554; CE18958; NM_060237; WBGene00001226; WP:CE18958 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T23H2.1 Aff_T23H2.1 npp-12; T23H2.1; 1H29; CE14106; NM_059454; WBGene00003798; WP:CE14106 npp-12 encodes Gp210, an evolutionarily conserved membrane protein of the nuclear pore complex (NPC); NPP-12 is required for embryonic viability and normal nuclear membrane structures. integral membrane protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T24D1.4 Aff_T24D1.4 tag-179; T24D1.4; 1K538; CE14168; WBGene00007043; WBGene00011987; WP:CE14168 Yeast DIE2 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T26E3.4 Aff_T26E3.4 T26E3.4; 1N259; CE24015; WBGene00012037; WP:CE24015 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated T26H2.2 Aff_T26H2.2 fbxb-115; T26H2.2; 5T708; CE16488; WBGene00012064; WP:CE16488 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated T27E9.3 Aff_T27E9.3 cdk-5; T27E9.3; 3O554; CE21213; NM_067382; WBGene00000407; WP:CE21213 cdk-5 encodes a putative homolog of cyclin dependent kinase 5 that affects pronuclear migration and rotation in one-cell embryos and may affect neuronal development; expressed in neurons. serine/threonine kinase (CDC2/CDKX subfamily) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E VF39H2L.1 Aff_VF39H2L.1 VF39H2L.1; 1J221; CE18300; WBGene00012150; WP:CE18300 ViswanathanM et al 2005 S2 sir-2.1 regulated W02A11.3 Aff_W02A11.3 W02A11.3; W02A11.3.1; W02A11.3.2; 1N331; CE18990; WBGene00012194; WP:CE18990 Zinc finger, C3HC4 type (RING finger) ViswanathanM et al 2005 S2 sir-2.1 regulated W02B12.8 Aff_W02B12.8 rga-1; W02B12.8; W02B12.8b.1; W02B12.8b.2; 2L757; CE03768; CE38231; WBGene00012203; WP:CE03768; WP:CE38231 GTPase-activating (rhoGAP) like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated W04A8.1 Aff_W04A8.1 W04A8.1; 1O428; CE16535; WBGene00012236; WP:CE16535 W04A8.1 encodes a protein weakly similar to human microcephalin (MCPH1; OMIM:607117, mutated in primary microcephaly); while their primary sequence similarity is very subtle (only being detectable with psi-BLAST on NCBI-nr, using C. briggsae CBG13622 as a query sequence), both W04A8.1 and microcephalin has similar ordering of BRCT domains (one N-terminal, two C-terminal); W04A8.1 has no obvious function in mass RNAi screens. BRCA1 C Terminus (BRCT) domain Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol W05H7.3 Aff_W05H7.3 sedl-1; W05H7.3; CE14652; NM_075871; WBGene00021046; WP:CE14652; XC58 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol W05H9.2 Aff_W05H9.2 W05H9.2; CE33720; WBGene00021049; WP:CE33720; XG889 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated W06H8.1 Aff_W06H8.E rme-1; W06H8.1; W06H8.1f.1; W06H8.1f.2; W06H8.1f.3; 5G697; CE25146; CE25147; CE25148; CE30204; CE31086; CE33335; WBGene00004373; WP:CE25146; WP:CE25147; WP:CE25148; WP:CE30204; WP:CE31086; WP:CE33335 The rme-1 gene encodes a C. elegans protein required for endocytosis. W07G4.4 Aff_W07G4.4 W07G4.4; 5N525; CE03794; WBGene00012338; WP:CE03794 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. cytosolic aminopeptidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated W08E3.3 Aff_W08E3.3 tag-210; W08E3.3; 1N935; CE14708; WBGene00012344; WBGene00044075; WP:CE14708 GTP-binding protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated W09C5.2 Aff_W09C5.2 unc-59; unc-88; W09C5.2; W09C5.2.1; W09C5.2.2; 1O225; CE20165; NM_060987; WBGene00006793; WP:CE20165 unc-59, by alternative splicing, encodes two septin isoforms required (like the septins UNC-61A/B) for normal axonal migration, distal tip cell migration, and postembryonic cytokinesis (at the cellular level) and for normal locomotion and formation of the postembryonic vulva, somatic gonad, and male tail (at the organismal level); both UNC-59 and UNC-61A/B are dispensable for embryonic cytokinesis and development, but are thought to be required for all postembryonic cytokinesis; UNC-59 and UNC-61A/B depend on each other for localization to the cytokinetic furrow. Cell division protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated W09D10.3 Aff_W09D10.3 W09D10.3; 3L797; CE16564; WBGene00012361; WP:CE16564 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ribosomal protein L7/L12 mitochondrial Golden et al 2004, N2 vs daf-2 age different gene, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y102A5A.1 Aff_Y102A5A.1 cand-1; Y102A5A.1; 5R293; CE20378; WBGene00013606; WP:CE20378 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y105C5A.14 Aff_Y105C5.N Y105C5A.14; 4Q408; CE39802; WBGene00013638; WP:CE39802 ViswanathanM et al 2005 S2 sir-2.1 regulated Y105E8B.2 Aff_Y105E8A.Y Y105E8B.2; Y105E8B.2b.1; Y105E8B.2b.2; 1P228; CE28785; CE34105; WBGene00013687; WP:CE28785; WP:CE34105 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma Y14H12B.1 Aff_Y14H12B_90.B Y14H12B.1; 2E225; CE21365; CE32075; CE39810; WBGene00021191; WP:CE21365; WP:CE32075; WP:CE39810 zinc-finger protein Jiang et al 2001 Fig1 hermaphrodite-enriched TF, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y17G7B.12 Aff_Y17G7B.12 Y17G7B.12; 2M315; CE19046; WBGene00012465; WP:CE19046 Exonuclease McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories Y18D10A.5 Aff_Y18D10A.F gsk-3; sgg-1; Y18D10A.5; Y18D10A.F; 1N417; CE21401; NM_060842; WBGene00001746; WP:CE21401 Eukaryotic protein kinase domain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y18D10A.9 Aff_Y18D10A.I Y18D10A.9; Y18D10A.I; 1N446; CE34506; WBGene00012479; WP:CE34506 WD domain, G-beta repeat McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y24D9A.2 Aff_Y24D9A_29.G Y24D9A.2; 4F157; CE33849; WBGene00021282; WP:CE33849 Y24D9A.2 encodes a histone H3 (Lys9) methyltransferase ortholog, predicted to function in transcriptional repression; Y24D9A.2 protein is specifically cleaved by CED-3, both in a genomic expression screen and in an in vitro assay. ViswanathanM et al 2005 S2 sir-2.1 regulated Y37D8A.13 Aff_Y37D8A.13 adm-1; max-3; unc-71; Y37D8A.13; 3N972; CE20217; NM_067279; WBGene00006804; WP:CE20217 unc-71 encodes an ADAM, a disintegrin and metalloprotease-containing transmembrane protein that is a member of the metzincin superfamily of proteases; UNC-71 is required non-cell autonomously for motor axon guidance and sex myoblast migration; UNC-71 does not appear to have an active metalloprotease domain, but functions with UNC-6/netrin and integrins INA-1/PAT-3 to provide guidance cues during axonal migration; UNC-71 is expressed in a restricted pattern in the excretory and excretory gland cells, some head neurons, the sphincter muscles, and hypodermal cells surrounding the vulva. Disintegrin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E Y37D8A.17 Aff_Y37D8A.17 Y37D8A.17; 3O12; CE20221; WBGene00012555; WP:CE20221 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y37D8A.4 Aff_Y37D8A.4 Y37D8A.4; 3N928; CE20209; WBGene00012546; WP:CE20209 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination Y37E11B.1 Aff_Y37E11B.1 Y37E11B.1; 4E345; CE33856; CE34609; WBGene00021374; WP:CE33856; WP:CE34609 zinc finger protein Y38H6C.10 Aff_Y38H6C.10 Y38H6C.10; 5U988; CE19104; WBGene00012623; WP:CE19104 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y39A1A.12 Aff_Y39A1A.12 Y39A1A.12; Y39A1A.12.1; Y39A1A.12.2; 3L735; CE19131; WBGene00012650; WP:CE19131 Y39A1A.12 encodes a homolog of origin recognition complex 1, which is also a distant paralog of CDC-6; both Y39A1A.12 and CDC-6 encode homologs of the origin complex which, in yeast, controls the start of DNA replication; whether either Y39A1A.12 or CDC-6 are required for this function in C. elegans, individually or in parallel, is unknown. ATPases associated with various cellular activities (AAA) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E Y39B6A.13 Aff_Y39B6.S Y39B6A.13; Y39B6B.S; 5T592; CE21694; WBGene00012675; WP:CE21694 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E Y39G8B.2 Aff_Y39G8B.D Y39G8B.2; 2O264; CE24244; WBGene00012723; WP:CE24244 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Shen et al 2005 T1 hif-1indepen hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated Y40B10A.8 Aff_Y40B10A_107.B nhr-86; Y40B10A.8; 5C540; CE31110; NM_071160; WBGene00003676; WP:CE31110 Y41D4B.9 Aff_Y41D4A_2699.A nhr-122; Y41D4B.9; 4C379; CE26096; NM_067708; WBGene00003712; WP:CE26096 ViswanathanM et al 2005 S2 sir-2.1 regulated Y43F8C.8 Aff_Y116F11.ZZ6 Y43F8C.8; 5U119; CE21906; WBGene00012830; WP:CE21906 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y44E3A.1 Aff_Y44E3A.G Y44E3A.1; Y44E3A.G; 1D913; CE21926; CE33225; WBGene00021547; WP:CE21926; WP:CE33225 Y45F10D.7 Aff_Y45F10D.8 Y45F10D.7; Y45F10D.8; 4O559; CE39843; WBGene00012887; WP:CE39843 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y46E12A.4 Aff_Y119D3_463.A Y46H3A.7 Aff_Y46H3A.H Y46H3A.7; CE38646; WBGene00044344; WP:CE38646 Y47D3A.15 Aff_Y47D3A.Q aakb-2; Y47D3A.15; 3M327; CE22044; WBGene00012928; WP:CE22044 McCarroll et al 2004 SFig5 conserved w/ yeast Y47G6A.6 Aff_Y47G6A_241.B pcaf-1; Y47G6A.6; 1E91; CE24372; NM_058772; WBGene00021636; WP:CE24372 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y48B6A.1 Aff_Y48B6A.A Y48B6A.1; Y48B6A.1.1; Y48B6A.1.2; 2O442; CE22116; WBGene00012978; WP:CE22116 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y48C3A.10 Aff_Y48C3A.K Y48C3A.10; 2N629; CE22143; WBGene00012992; WP:CE22143 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y48E1A.1 Aff_Y48E1A.1 Y48E1A.1; 2N962; CE22157; CE37860; WBGene00012999; WP:CE22157; WP:CE37860 DNA-directed RNA polymerase I largest subunit McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y48G8AL.13 Aff_Y48G8A_3051.A Y48G8AL.13; Y48G8AL.13.1; Y48G8AL.13.2; Y48G8AL.13.3; 1B698; CE22187; WBGene00021691; WP:CE22187 Lund et al 2002 Fig4 Mount 15, Romagnolo et al 2002 Fig3b Transporters, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y49A3A.2 Aff_Y49A3A.C phi-51; vha-13; Y49A3A.2; Y49A3A.2.1; Y49A3A.2.2; Y49A3A.2.3; Y49A3A.2.4; Y49A3A.B; Y49A3A.C; CE22210; NM_074158; WBGene00013025; WP:CE22210 ATP synthase alpha and beta subunits ; ATP synthase ab C terminal McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y49E10.1 Aff_Y49E10.C rpt-6; Y49E10.1; Y49E10.B; Y49E10.C; 3N461; CE22219; NM_067208; WBGene00004506; WP:CE22219 rpt-6 encodes a triple A ATPase that is a subunit of the 26S proteasome 19S regulatory particle (RP) base subcomplex; RPT-6 is required for embryonic and larval development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome. ATPases associated with various cellular activities (AAA) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated Y51A2D.17 Aff_Y51A2D.17 nhr-70; Y51A2D.17; 5T99; CE22324; NM_075235; WBGene00003660; WP:CE22324 Zinc finger, C4 type (two domains) ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y51H1A.4 Aff_Y51H1A.4 Y51H1A.4; Y51H1A.4.1; Y51H1A.4.2; CE20286; WBGene00013095; WP:CE20286 Y51H1A.4 is orthologous to the human gene P33ING1B (ING1; OMIM:601566), which when mutated leads to disease. PHD-finger. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated Y53C12A.1 Aff_Y53C12A.1 wee-1.3; spe-37; Y53C12A.1; 2K4; CE14884; NM_063694; WBGene00006940; WP:CE14884 serine/threonine kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster E Y54E10BR.5 Aff_Y54E10B_159.D Y54E10BR.5; 1D598; CE22466; WBGene00021844; WP:CE22466 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y54E2A.12 Aff_Y54E2A.12 Y54E2A.12; 2P85; CE37068; WBGene00013196; WP:CE37068 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated Y54E5B.2 Aff_Y54E5B.2 Y54E5B.2; 1P408; CE19226; WBGene00013204; WP:CE19226 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y55F3BR.8 Aff_Y55F3A_747.F Y55F3BR.8; 4B602; CE31657; CE37730; WBGene00021945; WP:CE31657; WP:CE37730 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated Y56A3A.12 Aff_Y56A3A.L Y56A3A.12; Y56A3A.12a.1; Y56A3A.12a.2; Y56A3A.12b.1; Y56A3A.12b.2; 3M990; CE24467; CE24468; WBGene00013232; WP:CE24467; WP:CE24468 Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y57A10A.23 Aff_Y57A10A.W Y57A10A.23; Y57A10A.23.1; Y57A10A.23.2; 2M531; CE22626; WBGene00013263; WP:CE22626 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y57E12AL.1 Aff_Y57E12_242.B Y57E12AL.1; Y57E12AL.1a.1; Y57E12AL.1a.2; 5H541; CE29890; CE29891; WBGene00021956; WP:CE29890; WP:CE29891 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57G11C.11 Aff_Y57G11C.11 coq-3; Y57G11C.11; 4P558; CE14946; NM_070388; WBGene00000763; WP:CE14946 coq-3 encodes a putative 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, orthologous to S. cerevisiae COQ3; COQ-3 is required for ubiquinone biosynthesis and for normally short lifespan; coq-3(RNAi) animals have reduced levels of coenzyme Q8, coenzyme Q9, and superoxide, and have abnormally long lifespans. dihydroxypolyprenylbenzoate methyltransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57G11C.13 Aff_Y57G11C.13 Y57G11C.13; 4P563; CE14950; WBGene00013309; WP:CE14950 ADP-ribosylation factor Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57G11C.15 Aff_Y57G11C.15 Y57G11C.15; Y57G11C.15.1; Y57G11C.15.2; Y57G11C.15.3; 4P588; CE14954; WBGene00013311; WP:CE14954 protein transport protein SEC61 alpha subunit McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y61A9LA.1 Aff_Y61A9LA_74.D Y61A9LA.1; 5F79; CE29895; WBGene00022014; WP:CE29895 ViswanathanM et al 2005 S2 sir-2.1 regulated Y63D3A.8 Aff_Y63D3A.8 Y63D3A.8; 1O709; CE39301; WBGene00013407; WP:CE39301 Y65B4BL.5 Aff_Y65B4B_9.A Y65B4BL.5; Y65B4BL.B; 1A982; CE24550; WBGene00022037; WP:CE24550 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated Y69H2.7 Aff_Y69H2.K Y69H2.7; Y69H2.K; 5T175; CE37450; WBGene00013482; WP:CE37450 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y6B3B.5 Aff_Y6B3B.5 Y6B3B.5; 1O344; CE37581; CE37582; WBGene00012390; WP:CE37581; WP:CE37582 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y71F9AL.9 Aff_Y71F9A_294.D Y71F9AL.9; Y71F9AL.9.1; Y71F9AL.9.2; Y71F9A_294.D; 1D445; CE22858; WBGene00022114; WP:CE22858 ViswanathanM et al 2005 S2 sir-2.1 regulated Y71F9B.8 Aff_Y71F9B_297.C Y71F9B.8; 1D304; CE25571; WBGene00022129; WP:CE25571 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y71H2AM.6 Aff_Y71H2_388.B Y71H2AM.6; 3D871; CE22938; WBGene00022171; WP:CE22938 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y75B8A.14 Aff_Y75B8A.R Y75B8A.14; 3N306; CE23026; WBGene00013550; WP:CE23026 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes Y75B8A.2 Aff_Y75B8A.C nob-1; Y75B8A.2; Y75B8A.C; 3N168; CE29009; CE29010; WBGene00003779; WP:CE29009; WP:CE29010 The nob-1 gene encodes one of three C. elegans posterior group homeodomain transcription factors orthologous to Drosophila Abd-B and the vertebrate Hox9-13 proteins; NOB-1, along with an additional posterior Hox ortholog, PHP-3, is required during embryogenesis for proper fate specification and morphogenesis of cells in the posterior region. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes Y75B8A.30 Aff_Y75B8A.NN pph-4.1; Y75B8A.30; 3N436; CE23041; NM_067202; WBGene00004085; WP:CE23041 Ser/Thr protein phosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y79H2A.6 Aff_Y79H2A.F arx-3; Y79H2A.6; 3N122; CE24672; NM_067169; WBGene00000201; WP:CE24672 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y82E9BR.1 Aff_Y119D3_465.J Y82E9BR.1; 3C557; CE27035; WBGene00022334; WP:CE27035 ViswanathanM et al 2005 S2 daf-16 Resveratrol Y94H6A.9 Aff_Y94H6A_132.B ubxn-2; Y94H6A.9; Y94H6A_132.B; 4D486; CE27555; CE33955; WBGene00022381; WP:CE27555; WP:CE33955 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph ZK1193.5 Aff_ZK1193.5 ZK1193.5; CE33746; CE33747; CE33748; WBGene00022861; WP:CE33746; WP:CE33747; WP:CE33748; XB46 ZK1193.5 encodes, by alternative splicing, three proteins with a COMPASS (CMP) domain and two homeodomains; the CMP domain is found in the N-terminus of SATB-class CUT homeodomain proteins (e.g. human SATB1), and in Drosophila DEFECTIVE PROVENTRICULUS (DVE), to which ZK1193.5 may be orthologous; both DVE and ZK1193.5 encode two homeodomains which are highly divergent, but homologous between species, and probably derived by intragenic duplication; ZK1193.5 is required for a normally high rate of growth, fluid excretion, and larval viability in in mass RNAi assays. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK1236.3 Aff_ZK1236.3 phi-57; ZK1236.3; 3J511; CE00532; WBGene00023405; WP:CE00532 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK228.3 Aff_ZK228.3 ZK228.3; 5S940; CE24719; WBGene00013946; WP:CE24719 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK265.9 Aff_ZK265.5 ZK265.9; 1I830; CE38132; WBGene00044094; WP:CE38132 Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK270.1 Aff_ZK270.1 ptr-23; ZK270.1; 1P503; CE15305; NM_061202; WBGene00004237; WP:CE15305 Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order ZK287.8 Aff_ZK287.8 her-1; ZK287.8; 5K181; CE06617; CE37304; WBGene00001842; WP:CE06617; WP:CE37304 The autosomal gene her-1 is repressed by SDC-2 to elicit hermaphrodite differentiation; SDC-2 also represses transcription of X chromosomes to achieve dosage compensation. Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes ZK455.1 Aff_ZK455.1 aco-1; gei-22; ZK455.1; ZK455.1.1; ZK455.1.2; CE03812; NM_077497; WBGene00000040; WP:CE03812; XL961 aco-1 encodes an aconitase that is homologous to mammalian iron regulatory protein-1 (IRP1); aco-1 activity is required for normal brood sizes and, under iron stress conditions, for normal lifespan and L4-to-adult growth rates; ACO-1 physically interacts with GEX-3; like IRP1, ACO-1 has aconitase activity and is post-translationally regulated by iron, but, unlike IRP1, it lacks RNA-binding activity; ACO-1 is predicted to be mitochondrial, and its mRNA levels appear to decrease in response to iron treatment. iron-responsive element-binding like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK622.3 Aff_ZK622.3 phi-40; ZK622.3; ZK622.3a.1; ZK622.3a.2; ZK622.3a.3; ZK622.3c.1; ZK622.3c.10; ZK622.3c.11; ZK622.3c.2; ZK622.3c.3; ZK622.3c.4; ZK622.3c.5; ZK622.3c.6; ZK622.3c.7; ZK622.3c.8; ZK622.3c.9; ZK622.3d.1; ZK622.3d.2; ZK622.3d.3; ZK622.3d.4; ZK622.3d.5; ZK622.3d.6; ZK622.3d.7; ZK622.3d.8; 2F570; CE29162; CE32290; CE33504; CE33505; WBGene00022781; WP:CE29162; WP:CE32290; WP:CE33504; WP:CE33505 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK792.6 Aff_ZK792.6 let-60; lin-34; ZK792.6; 4M454; CE03827; NM_069812; WBGene00002335; WP:CE03827 The let-60 gene encodes a member of the GTP-binding RAS protooncogene family that affects viability, vulval development, spicule development, germ line meiotic progression, posterior development of the hypodermis, and chemotaxis; it acts genetically downstream of let-23 with respect to vulval development and upstream of the MAPK pathway with respect to chemotaxis, and is expressed in neural, muscle, and hypodermal lineages. LET-60 RAS protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b signaling ZK809.5 Aff_ZK809.5 ZK809.5; 4M423; CE28874; CE33911; WBGene00014087; WP:CE28874; WP:CE33911 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK809.7 Aff_ZK809.7 prx-2; ZK809.7; 4M411; CE03835; NM_069800; WBGene00004192; WP:CE03835 prx-2 is orthologous to the human gene PEROXISOMAL MEMBRANE PROTEIN 3 (PXMP3; OMIM:170993), which when mutated leads to Zellweger syndrome 3 or infantile Refsum disease. Zinc finger, C3HC4 type (RING finger) Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order ZK909.5 Aff_ZK909.5 fbxb-70; ZK909.5; 1P546; CE15481; WBGene00014149; WP:CE15481 ViswanathanM et al 2005 S2 daf-16 Resveratrol