Baugh et al 2003, subclass MDpd_41min, 362 genes Gene list file name: Baugh2003_classMDpd_41min.txt Type of gene identifier: Affymetrix custom chip Description: Baugh et al 2005, Supplymental Dataset, subclass MDpd_41min Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations AFF_C05C8.1 Aff_C05C8.1 AFF_C06A1.4 Aff_C06A1.4 AFF_C33A11.2 Aff_C33A11.2 AFF_E01A2.I Aff_E01A2.I AFF_F44A2.6 Aff_F44A2.6 AFF_F49H12.D Aff_F49H12.D AFF_F58E10.1 Aff_F58E10.1 AFF_Y41D4A_3457.B Aff_Y41D4A_3457.B AFF_Y53G8B_93.B Aff_Y53G8B_93.B AFF_Y57E12_242.A Aff_Y57E12_242.A AFF_Y73F8A.AA Aff_Y73F8A.AA AFF_ZK546.13 Aff_ZK546.13 AH6.5 Aff_AH6.5 mex-6; AH6.5; 2J815; CE26846; NM_063642; WBGene00003231; WP:CE26846 mex-6 encodes a CCCH zinc-finger protein highly similar to MEX-5 that functions with MEX-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish PIE-1, MEX-1, and POS-1 asymmetry in embryos, and also affects formation of intestinal cells; MEX-6 and MEX-5 may act downstream of the PAR proteins. zinc finger protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0035.14 Aff_B0035.14 dnj-1; B0035.14; 4M69; CE05169; NM_069721; WBGene00001019; WP:CE05169 This gene encodes a protein containing a DnaJ ('J') domain. DNAJ protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0207.6 Aff_B0207.6 B0207.6; 1G512; CE30229; WBGene00015029; WP:CE30229 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0213.3 Aff_B0213.3 nlp-28; B0213.3; 5E463; CE16774; NM_071709; WBGene00003766; WP:CE16774 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination B0238.10 Aff_B0238.10 B0238.10; 5F753; CE07700; WBGene00015074; WP:CE07700 acyltransfersase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E B0304.2 Aff_B0304.2 B0304.2; 2E815; CE02424; WBGene00015134; WP:CE02424 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0334.11 Aff_B0334.11 mel-19; ooc-3; B0334.11; 2L784; CE19661; CE32788; NM_064055; NM_182110; WBGene00003868; WP:CE19661; WP:CE32788 ooc-3 encodes a nematode-specific protein with a predicted signal sequence, four predicted transmembrane domains, and two putative PEST sequences; OOC-3 is probably localized to the endoplasmic reticulum (ER), and is maternally required for correct localization of PAR-2 and PAR-3 in the P1 blastomere of the two-cell stage embryo; specifically, OOC-3 is required for restricting PAR-3 to the anterior cortex of the P1 blastomere to assure PAR-2 localization at the posterior cortex; more generally, OOC-3 is required to establish asymmetrical anterior-posterior cortical domains and spindle orientation in P1. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0334.4 Aff_B0334.4 B0334.4; 2L787; CE02936; WBGene00007144; WP:CE02936 Yeast hypothetical protein L8167.12 like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0393.6 Aff_B0393.6 B0393.6; 3F870; CE33964; WBGene00007171; WP:CE33964 Zinc finger, C3HC4 type (RING finger) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated B0464.4 Aff_B0464.4 bre-3; B0464.4; B0464.4.1; B0464.4.2; 3K560; CE33592; NM_066686; WBGene00000268; WP:CE33592 bre-3 encodes a protein similar to beta-glycosyltransferases from bacteria that is required for the toxicity of Bacillus thuringiensis Cry5B; BRE-3 may act in a pathway with bre-5 and is expressed and functions in the gut epithelium. zw4 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0511.12 Aff_B0511.12 B0511.12; 1L232; CE28877; WBGene00015237; WP:CE28877 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated B0547.1 Aff_B0547.1 csn-5; B0547.1; B0547.1.1; B0547.1.2; 4G415; CE06722; NM_068440; WBGene00000817; WP:CE06722 csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C01F6.8 Aff_C01F6.8 icl-1; C01F6.8; 4J860; CE17360; CE30069; ICln; WBGene00002046; WP:CE17360; WP:CE30069 The icl-1 gene encodes, through alternative splicing, two alternative forms (ICL-1A, or 'IClnN1', and ICL-1B, or 'IClnN2'), with distinct electrophysiological properties, of an anion channel homolog. nucleotide-sensitive chloride ion channel Kwon et al 2004 T1 late-induction Ethanol-response, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Transporters, ViswanathanM et al 2005 S2 sir-2.1 regulated C01G10.7 Aff_C01G10.7 C01G10.7; 5P567; CE07816; WBGene00007234; WP:CE07816 citrate lyase beta chain Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C01G5.2 Aff_C01G5.2 tag-292; C01G5.2; 4H292; CE06748; WBGene00015304; WP:CE06748 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C01G6.4 Aff_C01G6.4 C01G6.4; 2J562; CE00866; WBGene00007226; WP:CE00866 Zinc finger, C3HC4 type (RING finger) ViswanathanM et al 2005 S2 sir-2.1 regulated C02B10.1 Aff_C02B10.1 C02B10.1; 4F852; CE16798; IVD; WBGene00015326; WP:CE16798 The C02B10.1 gene encodes an isovaleryl-CoA dehydrogenase; this function has been verified by both sequence homology and direct biochemical assay. acyl-CoA dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C02B10.2 Aff_C02B10.2 C02B10.2; 4F854; CE24776; WBGene00015327; WP:CE24776 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C03E10.4 Aff_C03E10.4 gly-20; C03E10.4; 5L765; CE26613; GnT II; MGAT2; NM_073463; WBGene00001645; WP:CE26613 gly-20 is orthologous to the human gene MANNOSYL (ALPHA-1,6-)-GLYCOPROTEIN BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE (MGAT2; OMIM:602616), which when mutated leads to carbohydrate-deficient glycoprotein syndrome, type II. UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C04B4.2 Aff_C04B4.2 C04B4.2; CE05204; WBGene00007290; WP:CE05204; XM903 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C04F5.9 Aff_C04F5.9 C04F5.9; 5F594; CE19673; WBGene00015451; WP:CE19673 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C04G6.4 Aff_C04G6.4 C04G6.4; 2F372; CE32112; WBGene00015454; WP:CE32112 salt-stress induced peptide Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C05C10.6 Aff_C05C10.6 C05C10.6; CE02113; CE27796; WBGene00007333; WP:CE02113; WP:CE27796 phospholipase activating protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen C06A1.1 Aff_C06A1.1 cdc-48.1; phi-31; C06A1.1; 2K850; CE02114; NM_063872; WBGene00007352; WP:CE02114 transitional endoplasmic reticulum ATPase homolog 1 (P97 protein) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C06A5.6 Aff_C06A5.6 C06A5.6; 1G560; CE07953; WBGene00015504; WP:CE07953 Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C06A8.4 Aff_C06A8.4 skr-17; C06A8.4; 2I75; CE02455; NM_063237; WBGene00004823; WP:CE02455 skr-17 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-17 has no known function in vivo, since skr-17(RNAi) animals are at least superficially normal, and SKR-17 does not appear to interact in vitro with any of the C. elegans cullin homologs. Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C06E7.3 Aff_C06E7.3 C06E7.3; C06E7.3b.1; C06E7.3b.2; C06E7.3b.3; C06E7.3b.4; 4G610; CE03959; CE33517; WBGene00015540; WP:CE03959; WP:CE33517 S-adenosylmethionine synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C07G1.5 Aff_C07G1.5 hgrs-1; pqn-9; C07G1.5; 4I966; CE32574; NM_068974; WBGene00004101; WP:CE32574 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C07H4.2 Aff_C07H4.2 clh-5; C07H4.2; C07H4.2.1; C07H4.2.2; 2J386; CE27360; NM_063539; WBGene00000532; WP:CE27360 The clh-5 gene encodes a chloride channel, whose human homologs include CLC1 and CLCN5; the latter homolog is imvolved in receptor-mediated endocytosis. chloride channel protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C08B11.1 Aff_C08B11.1 zyg-11; C08B11.1; 2I309; CE01471; NM_063276; WBGene00006996; WP:CE01471 Leucine Rich Repeat (2 copies) Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination C08C3.4 Aff_C08C3.4 C08C3.4; 3I884; CE00069; CE39671; WBGene00015591; WP:CE00069; WP:CE39671 C08F8.2 Aff_C08F8.2 C08F8.2; C08F8.2b.1; C08F8.2b.2; 4L917; CE05249; CE19689; WBGene00007444; WP:CE05249; WP:CE19689 ATP-dependent RNA helicase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories C09F5.2 Aff_C09F5.2 C09F5.2; 3B271; CE01774; WBGene00015648; WP:CE01774 Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit C09G4.1 Aff_C09G4.1 LAG1-1; hyl-1; C09G4.1; C09G4.1.1; C09G4.1.2; 4J307; CE27675; NM_069058; WBGene00002043; WP:CE27675 hyl-1 encodes a predicted transmembrane protein that is related to Saccharomyces cerevisiae LAG1 (longevity assurance gene), a protein preferentially expressed in young yeasts; by homology, HYL-1 is predicted to have several possible functions, including regulation of lipid, particularly ceramide, biosynthesis, regulation of lipid transport, and regulation of protein translocation in the endoplasmic reticulum; in C. elegans, however, neither the precise role of HYL-1 in development and/or behavior nor the hyl-1 expression pattern is yet known. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C09G9.6 Aff_C09G9.6 moe-1; oma-1; C09G9.6; C09G9.6.1; C09G9.6.2; 4J655; CE03005; NM_069141; WBGene00003864; WP:CE03005 The oma-1 gene encodes a zinc finger protein of the TIS11 finger type that is paralogous to OMA-2; while either oma-1 or oma-2 individually have no obvious mutant phenotype, a normal copy of at least one of these genes is required for oocyte maturation. Zinc finger protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination C12D8.11 Aff_C12D8.11 rop-1; C12D8.11; C12D8.11.1; C12D8.11.2; 5K734; CE15613; NM_073237; WBGene00004405; WP:CE15613; rop1 ROP-1 ribonucleoprotein RO autoantigen ViswanathanM et al 2005 S2 sir-2.1 regulated C13B9.3 Aff_C13B9.3 phi-30; C13B9.3; 3H712; CE01778; WBGene00015734; WP:CE01778 C13B9.3 encodes a delta subunit of the coatomer (COPI) complex; in mass RNAi assays, C13B9.3 is required for fertility and general health. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C14A11.6 Aff_C14A11.6 C14A11.6; CE08154; WBGene00015751; WP:CE08154; XD426 C14C11.6 Aff_C14C11.6 mut-14; C14C11.6; 5G140; CE06825; NM_072089; WBGene00003507; WP:CE06825 mut-14 mutants exhibit germline transposon activation, a deficient response to RNAi, resistance to co-suppression, and transgene desilencing. helicase Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C14F11.1 Aff_C14F11.1 C14F11.1; C14F11.1b.1; C14F11.1b.2; CE02477; CE30862; WBGene00015778; WP:CE02477; WP:CE30862; XG861 Aspartate aminotransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C15H11.4 Aff_C15H11.4 dhs-22; C15H11.4; 5O900; CE08181; NM_074169; WBGene00000985; WP:CE08181 dhs-22 encodes a short-chain dehydrogenase predicted to be mitochondrial. dehydrogenase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C15H11.6 Aff_C15H11.6 nxf-2; C15H11.6; 5O896; CE36102; NM_074167; WBGene00003835; WP:CE36102 nxf-2 encodes a predicted homolog of human TAP protein, a member of the NXF family of shuttling transport receptors for nuclear export of mRNA, and it affects embryonic viability. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C16A11.4 Aff_C16A11.4 C16A11.4; 2E519; CE34688; WBGene00015817; WP:CE34688 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes C16A3.2 Aff_C16A3.2 C16A3.2; 3H479; CE08188; WBGene00015807; WP:CE08188 protein-tyrosine phosphatase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C16C10.1 Aff_C16C10.1 C16C10.1; C16C10.1.1; C16C10.1.2; 3F270; CE33519; WBGene00007622; WP:CE33519 carrier protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C16C8.12 Aff_C16C8.12 C16C8.12; 2D745; CE34693; WBGene00015850; WP:CE34693 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C17G10.2 Aff_C17G10.2 C17G10.2; 2F885; CE29583; WBGene00015916; WP:CE29583 TPR domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C18E9.6 Aff_C18E9.6 C18E9.6; 2J262; CE05298; WBGene00007686; WP:CE05298 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C18G1.5 Aff_C18G1.5 hil-4; C18G1.5; C18G1.5.1; C18G1.5.2; H1.4; 5F233; CE17421; NM_071876; WBGene00001855; WP:CE17421 histone H1 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C26E6.5 Aff_C26E6.5 fsn-1; C26E6.5; 3G27; CE01163; NM_065645; WBGene00001499; WBGene00016141; WP:CE01163 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C27A7.6 Aff_C27A7.6 C27A7.6; 5M604; CE08409; WBGene00007757; WP:CE08409 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C27D6.4 Aff_C27D6.5 C27D6.4; C27D6.4b.1; C27D6.4b.2; 2F468; CE32146; CE32147; CE32148; WBGene00016162; WP:CE32146; WP:CE32147; WP:CE32148 BZIP protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C27D9.1 Aff_C27D9.1 C27D9.1; 2F45; CE06891; WBGene00016163; WP:CE06891 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C28D4.2 Aff_C28D4.2 cka-1; C28D4.2; 4K498; CE20533; NM_069331; WBGene00000509; WP:CE20533 choline kinase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C29E4.8 Aff_C29E4.8 C29E4.8; C29E4.8.1; C29E4.8.2; 3J40; CE29198; WBGene00016205; WP:CE29198 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Adenylate kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C30F12.4 Aff_C30F12.4 C30F12.4; 1H548; CE16884; WBGene00016263; WP:CE16884 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C30H6.9 Aff_C30H6.9 C30H6.9; 4S322; CE19707; WBGene00007826; WP:CE19707 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C31H1.8 Aff_C31H1.8 C31H1.8; 4G576; CE27808; WBGene00016291; WP:CE27808 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C33F10.4 Aff_C33F10.4 C33F10.4; 2F87; CE02530; CE02531; CE27103; WBGene00016353; WP:CE02530; WP:CE02531; WP:CE27103 McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C34C12.8 Aff_C34C12.8 C34C12.8; 3E551; CE03057; WBGene00007927; WP:CE03057 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. GRPE protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C34D4.4 Aff_C34D4.4 C34D4.4; 4H913; CE06925; CE39683; WBGene00016400; WP:CE06925; WP:CE39683 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C34G6.7 Aff_C34G6.7 pqn-19; C34G6.7; C34G6.7a.1; C34G6.7a.2; C34G6.7b.1; C34G6.7b.2; 1G480; CE29700; CE32816; NM_059309; NM_182013; WBGene00004109; WP:CE29700; WP:CE32816 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C35B8.3 Aff_C35B8.3 C35B8.3; C35B8.3a.1; C35B8.3a.2; CE02536; CE27827; WBGene00016438; WP:CE02536; WP:CE27827; XJ835 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol C35D10.9 Aff_C35D10.9 ced-4; C35D10.9; 3F943; CE01203; CE38154; WBGene00000418; WP:CE01203; WP:CE38154 ced-4 encodes a novel protein; along with CED-3, CED-4 is required for the initiation of programmed cell death; accordingly, genetic analyses indicate that ced-3 and ced-4 function upstream of ced-1, ced-2, and nuc-1 in the programmed cell death pathway; in yeast two-hybrid experiments, and upon coexpression in mammalian cells, CED-4 interacts with CED-9, an anti-apoptotic BCL-2 homolog; coexpression of CED-4 and CED-9 results in redistribution of CED-4 from the cytosol to organellar membranes, suggesting that CED-9 may negatively regulate CED-4 activity by sequestering CED-4 to intracellular membranes. Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C36A4.4 Aff_C36A4.4 C36A4.4; C36A4.4.1; C36A4.4.2; 3E932; CE27831; WBGene00007965; WP:CE27831 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C36A4.9 Aff_C36A4.9 C36A4.9; C36A4.9a.1; C36A4.9a.2; C36A4.9a.3; 3E955; CE03076; CE37209; WBGene00007969; WP:CE03076; WP:CE37209 acetyl-coenzyme A synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Shen et al 2005 T1 hif-1 depend hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated C36F7.2 Aff_C36F7.2 C36F7.2; 1K133; CE24828; WBGene00007985; WP:CE24828 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C37H5.3 Aff_C37H5.3 C37H5.3; 5F325; CE08627; CE32824; WBGene00016507; WP:CE08627; WP:CE32824 Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, IVb male soma enriched genes, Reinke et al 2004, mixed sperm soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched C38D4.6 Aff_C38D4.6 ceh-3; nob-2; pal-1; C38D4.6; C38D4.6a.1; C38D4.6a.2; C38D4.6b.1; C38D4.6b.2; 3F896; CE05383; CE27837; NM_065590; WBGene00003912; WP:CE05383; WP:CE27837 pal-1 encodes a homeodomain protein that is the C. elegans Caudal ortholog; PAL-1 is required maternally and embryonically for cell fate specification and posterior patterning during embryogenesis; PAL-1 is also required postembryonically for fate specification of the posterior V6 neuroectoblast during male tail development; PAL-1 is expressed in posterior blastomeres beginning at the four-cell stage of embryogenesis and its expression continues during embryogenesis in posterior-derived tissues and cells undergoing movement or forming midline structures; pal-1 is subject to both transcriptional and translational regulation. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E C42C1.16 Aff_C42C1.10 C42C1.16; 4N49; CE29223; WBGene00016593; WP:CE29223 C45G9.2 Aff_C45G9.2 C45G9.2; 3G159; CE29722; WBGene00016674; WP:CE29722 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated C46H3.2 Aff_C46H3.2 C46H3.2; C46H3.2b.1; C46H3.2b.2; CE29228; CE33921; WBGene00016725; WP:CE29228; WP:CE33921; XB832 tyrosine-protein kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C48B4.8 Aff_C48B4.8 C48B4.8; 3K650; CE00484; WBGene00008171; WP:CE00484 ViswanathanM et al 2005 S2 sir-2.1 regulated C48B4.9 Aff_C48B4.9 C48B4.9; 3K652; CE00485; WBGene00008172; WP:CE00485 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C50B8.1 Aff_C50B8.1 C50B8.1; C50B8.1.1; C50B8.1.2; 5O47; CE08881; WBGene00008224; WP:CE08881 RNA binding protein ViswanathanM et al 2005 S2 sir-2.1 regulated C50B8.2 Aff_C50B8.2 bir-2; C50B8.2; 5O49; CE08882; NM_073961; WBGene00000250; WP:CE08882 The bir-2 gene encodes a protein with two BIR domains that may be involved in apoptosis. Inhibitor of Apoptosis domain. McElwee et al 2003 T1 targets of daf-16, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C50F4.16 Aff_C50F4.11 C50F4.16; C50F4.16.1; C50F4.16.2; 5K18; CE28213; WBGene00008238; WP:CE28213 The C50F4.16 gene encodes a NUDIX hydrolase. C52B11.3 Aff_C52B11.3 dop-4; C52B11.3; CE39139; WBGene00016872; WP:CE39139; XB915 G-protein coupled receptor C52E4.4 Aff_C52E4.4 rpt-1; C52E4.4; C52E4.4.1; C52E4.4.2; C52E4.4.3; 5M462; CE08946; NM_073604; WBGene00004501; WP:CE08946 rpt-1 encodes a predicted ATPase subunit of the 19S regulatory complex of the proteasome that affects fertility and embryonic viability. 26S protease regulatory subunit 7 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C53A5.2 Aff_C53A5.2 C53A5.2; 5P0; CE17599; WBGene00008263; WP:CE17599 Neurospora met-10 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C53D6.4 Aff_C53D6.4 C53D6.4; 4J784; CE36284; WBGene00008281; WP:CE36284 angiotensin receptor like Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C55B7.11 Aff_C55B7.11 C55B7.11; 1H88; CE09022; WBGene00016947; WP:CE09022 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C55C3.5 Aff_C55C3.5 C55C3.5; 4G462; CE29735; WBGene00016955; WP:CE29735 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C56A3.6 Aff_C56A3.6 C56A3.6; 5O34; CE32339; WBGene00008345; WP:CE32339 EF hand (2 domains) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C56G2.6 Aff_C56G2.6 dhs-10; let-767; C56G2.6; C56G2.6.1; C56G2.6.2; 3H428; CE30639; NM_065985; WBGene00002891; WP:CE30639 let-767 encodes a short-chain dehydrogenase, reported to be required for efficient cholesterol metabolism; LET-767 is predicted to be required for the metabolism of a sterol and to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 CD4.4 Aff_CD4.4 CD4.4; 5G71; CE16952; WBGene00016990; WP:CE16952 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated D1007.10 Aff_D1007.10 D1007.10; 1F157; CE09045; CE34282; CE36921; WBGene00017007; WP:CE09045; WP:CE34282; WP:CE36921 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated D1014.2 Aff_D1014.2 SRQ-5; D1014.2; 5I625; CE07004; WBGene00017015; WP:CE07004 D1054.2 Aff_D1054.2 pas-2; tag-166; D1054.2; 5L251; CE05521; NM_073349; WBGene00003923; WP:CE05521 pas-2 encodes a proteasome subunit with highest similarity to vertebrate proteasome alpha 2 subunits. proteasome component C3 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated D1086.4 Aff_D1086.4 D1086.4; 5O571; CE09062; WBGene00008391; WP:CE09062 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated D2013.6 Aff_D2013.6 D2013.6; 2J621; CE00931; WBGene00008404; WP:CE00931 ViswanathanM et al 2005 S2 sir-2.1 regulated D2021.2 Aff_D2021.2 tag-233; D2021.2; CE34286; CE34287; WBGene00017047; WBGene00044071; WP:CE34286; WP:CE34287; XJ173 Jones et al 2001 Dauer specific genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit D2024.6 Aff_D2024.6 cap-1; D2024.6; D2024.6.1; D2024.6.2; 4H994; CAPZ/A; CE04295; NM_068744; WBGene00000292; WP:CE04295 cap-1 encodes an F-actin capping protein alpha subunit that affects fertility; likely expressed in touch receptor neurons. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated D2030.5 Aff_D2030.5 mce-1; D2030.5; 1I159; CE09082; WBGene00008415; WP:CE09082 B.subtilis YQJC protein like ViswanathanM et al 2005 S2 sir-2.1 regulated D2030.7 Aff_D2030.7 D2030.7; D2030.7.1; D2030.7.2; 1I165; CE30270; WBGene00008417; WP:CE30270 Zinc finger, C3HC4 type (RING finger) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination D2063.3 Aff_D2063.A D2063.3; 5E818; CE29745; CE36922; WBGene00017062; WP:CE29745; WP:CE36922 D2089.3 Aff_D2089.3 D2089.3; 2K952; CE00938; WBGene00008434; WP:CE00938 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph E02H1.5 Aff_E02H1.5 E02H1.5; 2J885; CE01540; WBGene00008457; WP:CE01540 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated EEED8.10 Aff_EEED8.10 EEED8.10; 2F686; CE39344; WBGene00017138; WP:CE39344 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Probable RNA binding protein. Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F01F1.8 Aff_F01F1.8 cct-6; F01F1.8; F01F1.8a.1; F01F1.8a.2; F01F1.8b.1; F01F1.8b.2; F01F1.8b.3; 3G944; CE01234; CE30647; NM_171135; NM_171136; WBGene00000381; WP:CE01234; WP:CE30647 eukaryotic cytosolic chaperonin; affects viability and fertility, and is expressed in various muscle and neuronal cells: near the pharynx, near the anal sphincter, in the ventral nerve cord and the nerve ring; occasionally the expression is visible in hypodermal cells and in some vulval cells. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F02D10.6 Aff_F02D10.6 F02D10.6; CE03141; WBGene00008526; WP:CE03141; XO70 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F02E8.3 Aff_F02E8.3 aps-2; F02E8.3; CE07018; NM_076366; WBGene00000157; WP:CE07018; XF77 The aps-2 gene encodes an adaptin: specifically, it encodes an ortholog of the sigma2 subunit of adaptor protein complex 2 (AP-2), which mediates endocytosis from the plasma membrane; APS-2 appears to be required for embryonic and larval development and for normal body morphology, but is not required for endocytosis of yolk protein in developing oocytes; APS-2 is expressed in nearly all cells during embryogenesis, but during larval and adult stages, expression is confined to neurons and some hypodermal cells, including vulval hypodermal cells during the fourth larval stage. Clathrin coat assembly protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F02E8.4 Aff_F02E8.4 F02E8.4; CE07019; WBGene00017177; WP:CE07019; XF75 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F02E9.5 Aff_F02E9.5 F02E9.5; 1J2; CE23628; WBGene00008530; WP:CE23628 Jones et al 2001 Dauer specific genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F02H6.4 Aff_F02H6.4 F02H6.4; 4O981; CE17628; WBGene00008537; WP:CE17628 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F07H5.10 Aff_F07H5.10 F07H5.10; 2J98; CE28906; WBGene00008561; WP:CE28906 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08F3.2 Aff_F08F3.2 acl-6; F08F3.2; F08F3.2a.1; F08F3.2a.2; 5F913; CE09258; CE35851; WBGene00017261; WP:CE09258; WP:CE35851 glycerol-3-phosphate acyltransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F08F8.2 Aff_F08F8.2 F08F8.2; 3I451; CE30649; WBGene00017268; WP:CE30649 Hydroxymethylglutaryl-coA reductase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F08G2.4 Aff_F08G2.4 F08G2.4; 2O121; 2O123; CE19776; WBGene00008576; WP:CE19776 Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F09E5.13 Aff_F09E5.13 agt-2; cAGT-2; F09E5.13; 2F660; CE02608; NM_062607; WBGene00000094; WP:CE02608 agt-2 encodes a paralog of the DNA repair enzyme O6-Alkylguanine DNA-alkyltransferase (AGT); AGT-2 has AGT biochemical activity and is expressed at all developmental stages. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F09E5.7 Aff_F09E5.7 F09E5.7; F09E5.7.1; F09E5.7.2; 2F643; CE02614; WBGene00017285; WP:CE02614 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F09E8.3 Aff_F09E8.3 msh-5; F09E8.3; 4N927; CE26678; NM_070130; WBGene00003421; WP:CE26678 msh-5 encodes a germline-specific homolog of the yeast and mammalian DNA mismatch repair protein MSH5 (MutS-family) that is required for crossing over and chiasma formation during Caenorhabditis elegans meiosis; inactivation of both rad-51 and msh-5 induces chromosome fragmentation, not seen with inactivation of either gene alone. Yeast DNA mismatch repair protein MSH5 like McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F10G7.9 Aff_F10G7.9 F10G7.9; F10G7.9b.1; F10G7.9b.2; 2E994; CE32371; CE32372; WBGene00017372; WP:CE32371; WP:CE32372 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F11A10.5 Aff_F11A10.5 F11A10.5; 4M859; CE03185; WBGene00008686; WP:CE03185 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F11G11.7 Aff_F11G11.7 dnj-9; F11G11.7; 2F149; CE07060; NM_062471; WBGene00001027; WP:CE07060 This gene encodes a protein containing a DnaJ ('J') domain. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F12F6.6 Aff_F12F6.6 sec-24.1; F12F6.6; 4M328; CE05594; NM_069777; WBGene00004755; WP:CE05594 sec-24.1 encodes one of two C. elegans Sec24 homologs; in Saccharomyces cerevisiae, Sec24 is a member of the Sec24-Sec23 subunit of the COPII coat complex, assembly of which is essential for the first step of secretory protein transport from the endoplasmic reticulum (ER) to the Golgi; by homology with Sec24, SEC-24.1 is predicted to facilitate vesicle cargo selection, and likely contains multiple, independent sites for binding to secreted proteins; loss of sec-24.1 activity via RNAi indicates that SEC-24.1 is required for cuticle secretion and oogenesis. Yeast hypothetical YIK9 protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F13B9.8 Aff_F13B9.8 fis-2; F13B9.8; CE04385; CE37102; WBGene00001425; WP:CE04385; WP:CE37102; XI900 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F13D12.2 Aff_F13D12.2 ldh-1; F13D12.2; 2M15; CE02181; LDH; NM_064102; WBGene00002262; WP:CE02181 ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency. L-lactate dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F13G3.4 Aff_F13G3.4 dylt-1; F13G3.4; 1H876; CE17659; NM_059662; WBGene00008764; WP:CE17659 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated F13H10.4 Aff_F13H10.4 F13H10.4; 4L782; CE05625; WBGene00008775; WP:CE05625 F13H10.4 is orthologous to the human gene A-GLUCOSIDASE I (GCS1; OMIM:601336), which when mutated leads to disease. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F14D2.4 Aff_F14D2.4 bath-29; F14D2.4; 2D647; CE16979; CE31788; WBGene00017452; WP:CE16979; WP:CE31788 Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F17H10.1 Aff_F17H10.1 F17H10.1; CE03226; WBGene00008925; WP:CE03226; XN725 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F20B6.2 Aff_F20B6.2 vha-12; F20B6.2; F20B6.2.1; F20B6.2.2; CE04424; NM_076310; WBGene00006921; WP:CE04424; XE811 vacuolar ATP synthase (strong) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F20H11.3 Aff_F20H11.3 mdh-1; F20H11.3; F20H11.3.1; F20H11.3.2; F20H11.3.3; 3H696; CE09512; NM_066056; WBGene00003162; WP:CE09512 mdh-1 encodes a homolog of malate dehydrogenase that is predicted to be mitochondrial. malate dehydrogenase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F21G4.2 Aff_F21G4.2 mrp-4; F21G4.2; CE09548; NM_077257; WBGene00003410; WP:CE09548; XK507 The mrp-4 gene encodes a homolog of human CFTR, which when mutated leads to cystic fibrosis (OMIM:219700). multidrug resistance-associated protein Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F22D6.3 Aff_F22D6.3 nrs-1; F22D6.3; F22D6.3a.1; F22D6.3a.2; 1H664; CE05684; WBGene00003815; WP:CE05684 nrs-1 encodes an asparaginyl-tRNA synthetase that is required for embryonic viability and fertility asparaginyl-tRNA synthetase Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F22E5.9 Aff_F22E5.9 F22E5.9; 2C927; CE09561; WBGene00017708; WP:CE09561 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F25B5.3 Aff_F25B5.3 F25B5.3; F25B5.3c.1; F25B5.3c.2; F25B5.3c.3; F25B5.3c.4; 3H41; CE26890; CE28001; CE29776; CE30663; CE30664; WBGene00017775; WP:CE26890; WP:CE28001; WP:CE29776; WP:CE30663; WP:CE30664 F25B5.3 is orthologous to the human gene NUCLEOTIDASE, 5-PRIME, CYTOSOLIC III (NT5C3; OMIM:606224), which when mutated leads to hemolytic anemia due to UMPH1 deficiency McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F25D1.1 Aff_F25D1.1 tag-93; F25D1.1; 5L14; CE05722; CE36134; WBGene00006460; WP:CE05722; WP:CE36134 protein phosphatase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F25D7.1 Aff_F25D7.1 cup-2; tag-352; F25D7.1; 1K976; CE09629; WBGene00000843; WBGene00009111; WP:CE09629 The primary phenotype of cup-2 animals is an accumulation of secreted GFP in the pseudocoelom, suggesting a decrease in, or the absence of, endocytosis in coelomocytes. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F25H2.13 Aff_F25H2.13 F25H2.13; 1L153; CE15894; WBGene00009124; WP:CE15894 DEAH-type helicase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol F26B1.2 Aff_F26B1.2 F26B1.2; F26B1.2c.1; F26B1.2c.2; F26B1.2c.3; 1G895; CE09674; CE33057; CE33058; CE33059; CE33060; WBGene00017816; WP:CE09674; WP:CE33057; WP:CE33058; WP:CE33059; WP:CE33060 RNA-binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F26F4.4 Aff_F26F4.4 tag-340; F26F4.4; F26F4.4.1; F26F4.4.2; F26F4.4.3; 3F991; CE30767; WBGene00017826; WP:CE30767 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F26H11.4 Aff_F26H11.4 F26H11.4; 2O697; CE15911; WBGene00009182; WP:CE15911 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F26H11.5 Aff_F26H11.5 exl-1; F26H11.5; 2O698; CE24922; NM_064599; WBGene00001371; WP:CE24922 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F27C8.6 Aff_F27C8.6 F27C8.6; F27C8.6.1; F27C8.6.2; 4K352; CE03271; WBGene00009186; WP:CE03271 esterase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination F28F8.6 Aff_F28F8.6 atx-3; tag-70; F28F8.6; 5Q56; CE09760; NM_074472; WBGene00006446; WP:CE09760 tag-70/F28F8.6 encodes an ortholog of human ATAXIN-3 (OMIM:607047, mutated in Machado-Joseph disease). Human Machedo-Joseph disease protein 1 like Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol F29G9.2 Aff_F29G9.2 F29G9.2; F29G9.2b.1; F29G9.2b.2; F29G9.2b.3; CE09796; CE27374; NM_072159; NM_182341; WBGene00017931; WP:CE09796; WP:CE27374 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E F30F8.1 Aff_F30F8.1 F30F8.1; 1I410; CE09813; WBGene00009270; WP:CE09813 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E F30F8.9 Aff_F30F8.3 F30F8.9; F30F8.9a.1; F30F8.9a.2; F30F8.9b.1; F30F8.9b.2; 1I415; CE27148; CE32398; WBGene00009276; WP:CE27148; WP:CE32398 F31B9.3 Aff_F31B9.3 F31B9.3; CE17729; WBGene00009280; WP:CE17729; XQ541 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F32B6.8 Aff_F32B6.8 F32B6.8; F32B6.8a.1; F32B6.8a.2; F32B6.8b.1; F32B6.8b.2; 4K665; CE09863; CE35519; WBGene00009322; WP:CE09863; WP:CE35519 Yeast ORF YOR070C protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F33A8.5 Aff_F33A8.5 F33A8.5; F33A8.5.1; F33A8.5.2; 2L340; CE17757; WBGene00009353; WP:CE17757 F33A8.5 is orthologous to the human gene SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT D, INTEGRAL MEMBRANE PROTEIN (SDHD; OMIM:602690), which when mutated leads to disease. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F33G12.2 Aff_F33G12.2 F33G12.2; 2F320; CE27149; WBGene00018014; WP:CE27149 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F33G12.3 Aff_F33G12.3 F33G12.3; 2F322; CE04481; WBGene00018015; WP:CE04481 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories F35D11.4 Aff_F35D11.4 F35D11.4; 2E893; CE32648; WBGene00018045; WP:CE32648 Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S4 Climbing, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S4 genes pass two-wayANOVA P0 F35H10.7 Aff_F35H10.7 F35H10.7; 4J63; CE04507; WBGene00018072; WP:CE04507 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F37C12.2 Aff_F37C12.2 F37C12.2; 3I275; CE00741; WBGene00018150; WP:CE00741 Link et al 2003 T2 Abeta induced, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F38H4.10 Aff_F38H4.10 F38H4.10; 4M625; CE32887; WBGene00009551; WP:CE32887 Yeast hypothetical protein YIK6 like Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F38H4.8 Aff_F38H4.8 ech-2; F38H4.8; 4M616; CE17808; NM_069845; WBGene00001151; WP:CE17808 enoyl-CoA hydratase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 F39H2.3 Aff_F39H2.3 F39H2.3; 1J241; CE37516; WBGene00009563; WP:CE37516 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. S.pombe hypothetical protein C21E11.07 like Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F40A3.3 Aff_F40A3.3 F40A3.3; F40A3.3b.1; F40A3.3b.2; 5I359; CE10146; CE38516; WBGene00018218; WP:CE10146; WP:CE38516 phosphatidylethanolamine binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 F40F9.7 Aff_F40F9.7 F40F9.7; F40F9.7a.1; F40F9.7a.2; F40F9.7b.1; F40F9.7b.2; F40F9.7b.3; F40F9.7b.4; 5K213; CE05856; CE33580; WBGene00009584; WP:CE05856; WP:CE33580 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F40G9.11 Aff_F40G9.11 mxl-2; F40G9.11; 3A804; CE19858; NM_064772; WBGene00003510; WP:CE19858 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F41H10.10 Aff_F41H10.10 htp-1; tag-35; F41H10.10; 4G156; CE31692; NM_068398; WBGene00002032; WP:CE31692 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F41H10.11 Aff_F41H10.4 sand-1; F41H10.11; 4G133; CE31693; WBGene00018321; WP:CE31693 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F41H10.3 Aff_F41H10.3 F41H10.3; 4G139; CE10276; CE31694; WBGene00018316; WP:CE10276; WP:CE31694 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F43C1.4 Aff_F43C1.4 nhr-20; F43C1.4; 3F320; CE28025; NM_065448; WBGene00003619; WP:CE28025 Zinc finger, C4 type (two domains) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma F44F4.2 Aff_F44F4.2 F44F4.2; F44F4.2.1; F44F4.2.2; 2L174; CE00998; WBGene00009701; WP:CE00998 Protein-tyrosine phosphatase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F45G2.3 Aff_F45G2.3 F45G2.3; 3O513; CE28728; WBGene00009731; WP:CE28728 XPG N-terminal domain, XPG I-region McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E F46B6.6 Aff_F46B6.6 F46B6.6; 5K264; CE26974; WBGene00009771; WP:CE26974 initiation factor IF-2 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F46C5.8 Aff_F46C5.8 F46C5.8; 2J103; CE03349; WBGene00009783; WP:CE03349 endoplasmic reticular protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F46C5.9 Aff_F46C5.9 F46C5.9; 2J100; CE10584; WBGene00009784; WP:CE10584 G-protein ViswanathanM et al 2005 S2 sir-2.1 regulated F48E8.6 Aff_F48E8.6 F48E8.6; 3G535; CE02758; WBGene00018612; WP:CE02758 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F52E1.1 Aff_F52E1.1 pos-1; F52E1.1; 5I895; CE04629; NM_072771; WBGene00004078; WP:CE04629 pos-1 encodes a CCCH-type zinc-finger protein; during embryogenesis, maternally provided POS-1 is essential for proper fate specification of germ cells, intestine, pharynx, and hypodermis; POS-1's role in cell fate specification is likely as a translational regulator, as POS-1 is required, in posterior blastomeres, for positive regulation of apx-1 mRNA translation and negative regulation of glp-1 mRNA translation via direct binding to the spatial control region (SCR) in the glp-1 mRNA 3' UTR; in regulating mRNA translation, POS-1 interacts with SPN-4, an RNP-type RNA binding protein, that may function to negatively regulate POS-1 activity; pos-1 mRNA is first detected in the gonads of L4 and adult animals, and is present uniformly in oocytes and newly fertilized embryos; during early embryonic divisions, pos-1 mRNA is present at higher levels in germline blastomeres until it disappears following the division of P4; POS-1 protein is first apparent at low levels in 1-cell embryos, with subsequent expression mirroring that of pos-1 mRNA: high levels in germline blastomeres until its disappearance after the P4 division; in the germline blastomeres P1, P2, P3, and P4, POS-1 colocalizes with cytoplasmic and perinuclear P granules. zinc-finger protein Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination F54E7.3 Aff_F54E7.3 par-3; F54E7.3; 3G765; CE28449; CE28450; CE39941; NM_065816; WBGene00003918; WP:CE28449; WP:CE28450; WP:CE39941 par-3 encodes a PDZ domain-containing protein orthologous to mammalian atypical PKC isotype-specific interacting protein (ASIP) and Drosophila Bazooka; PAR-3 is required maternally for polarization of the zygote along the anterior-posterior (A-P) axis; PAR-3, PAR-6, and PKC-3 form a complex that localizes to the anterior cytoplasmic cortex of the one- and two-cell embryo; this localization is regulated spatially by PAR-2, which segregates to the posterior cortex. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F56C11.5 Aff_F56C11.5 F56C11.5; 1A651; CE34322; WBGene00018957; WP:CE34322 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F56C9.3 Aff_F56C9.3 F56C9.3; 3I401; CE29406; NM_066210; WBGene00018948; WP:CE29406 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F56D1.7 Aff_F56D1.5 daz-1; F56D1.7; 2F747; CE27175; NM_062635; WBGene00000935; WP:CE27175 daz-1 encodes a protein containing an RNA recognition motif that is required for the progression of meiosis during oogenesis; expressed in the germline and expression levels peak in the proximal pachytene region. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F56H11.4 Aff_F56H11.4 elo-1; pea-1; F56H11.4; 4K291; CE05979; CEEL01; NM_069288; WBGene00001239; WP:CE05979; ceelo1 elo-1 encodes a component of C-18 polyunsaturated fatty acid (PUFA) elongase that is required for normal elongation of n-6 and n-3 20-carbon PUFA in vivo; ELO-1 is a condensing enzyme that elongates n-6 and n-7 (and, with less efficiency, n-3) series C18 PUFAs. Yeast YJT6 like McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F57B9.6 Aff_F57B9.6 inf-1; F57B9.6; F57B9.6a.1; F57B9.6a.2; 3I21; CE01341; CE38524; Ce1F; CeIF; NM_066108; WBGene00002083; WP:CE01341; WP:CE38524 inf-1 encodes a protein with high similarity to eukaryotic initiation factor 4A. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F57B9.7 Aff_T07E3.7 F57B9.7; 3I14; CE31011; CE31012; WBGene00018998; WP:CE31011; WP:CE31012 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F57C9.7 Aff_F57C9.7 F57C9.7; 1F394; CE11334; WBGene00019013; WP:CE11334 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F58B3.6 Aff_F58B3.6 F58B3.6; F58B3.6.1; F58B3.6.2; F58B3.6.3; 4M401; CE06008; WBGene00010232; WP:CE06008 interferon-related protein PC4 like Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F58G1.1 Aff_F58G1.1 F58G1.1; 2N213; CE17921; WBGene00010263; WP:CE17921 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated F58G1.2 Aff_F58G1.2 F58G1.2; F58G1.2.1; F58G1.2.2; 2N206; CE35561; WBGene00010264; WP:CE35561 Zinc finger, C2H2 type (6 domains) Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F59D12.5 Aff_F59D12.5 F59D12.5; CE19909; WBGene00010332; WP:CE19909; XQ262 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma F59G1.1 Aff_F59G1.1 F59G1.1; F59G1.1b.1; F59G1.1b.2; F59G1.1b.3; F59G1.1c.1; F59G1.1c.2; F59G1.1d.1; F59G1.1d.2; F59G1.1d.3; F59G1.1d.4; F59G1.1d.5; 2G205; CE29810; CE29811; CE30378; CE33409; WBGene00019127; WP:CE29810; WP:CE29811; WP:CE30378; WP:CE33409 ViswanathanM et al 2005 S2 sir-2.1 regulated F59G1.7 Aff_F59G1.7 frh-1; F59G1.7; F59G1.7.1; F59G1.7.2; 2G207; CE19476; NM_062782; WBGene00001486; WP:CE19476 frh-1 encodes the C. elegans frataxin ortholog;, by homology, FRH-1 is predicted to be a mitochondrial protein required for biogenesis of iron-sulfur clusters, co-factors necessary for proper function of electron transport chain proteins; in C. elegans, loss of frh-1 activity via RNAi results in small body size, pale coloration, reduced egg-laying and fertility, altered responses to oxidative stress, and a significant lifespan extension. Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated H19N07.1 Aff_H19N07.1 phi-19; H19N07.1; H19N07.1.1; H19N07.1.2; 5L592; CE32460; WBGene00010405; WP:CE32460 elongation factor McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA H19N07.3 Aff_H19N07.3 H19N07.3; H19N07.3.1; H19N07.3.2; 5L598; CE16184; WBGene00010407; WP:CE16184 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination H19N07.4 Aff_H19N07.4 H19N07.4; H19N07.4.1; H19N07.4.2; 5L600; CE16185; WBGene00010408; WP:CE16185 H19N07.4 encodes an integral membrane protein with acyl-CoA:diacylglycerol o-acyltransferase activity when expressed in yeast; H19N07.4 belongs to the MBOAT protein family, whose biochemically characterized members transfer fatty acids or acetate to membrane-associated hydroxyl-bearing substrates such as cholesterol, diacylglycerol, long-chain alcohols, or alginate; MBOAT proteins include MOM-1 and its Drosophila homolog PORCUPINE, involved in Wnt signalling; H19N07.4 has no obvious function in mass RNAi assays. McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched H20J04.5 Aff_H20J04_717.C tag-355; H20J04.5; H20J04.5.1; H20J04.5.2; H20J04.5.3; 2E617; CE23815; WBGene00019220; WP:CE23815 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated H21P03.1 Aff_H21P03.1 mbf-1; H21P03.1; 4M244; CE18819; NM_069765; WBGene00003148; WP:CE18819 Helix-turn-helix McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated H21P03.2 Aff_H21P03.2 H21P03.2; 4M247; CE18820; WBGene00010409; WP:CE18820 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated H25P06.1 Aff_H25P06.1 H25P06.1; H25P06.1.1; H25P06.1.2; 1L904; CE18823; WBGene00010416; WP:CE18823 Hexokinases ViswanathanM et al 2005 S2 sir-2.1 regulated K01G5.1 Aff_K01G5.1 tag-331; K01G5.1; 3K846; 3L846; CE26718; WBGene00010476; WP:CE26718 Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E K02B2.1 Aff_K02B2.1 K02B2.1; 4G707; CE30082; WBGene00019295; WP:CE30082 6-phosphofructo-2-kinase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol K02B2.4 Aff_K02B2.4 inx-7; opu-7; K02B2.4; 4G708; CE04690; NM_068493; WBGene00002129; WP:CE04690 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K02B9.1 Aff_K02B9.1 K02B9.1; CE16206; WBGene00010492; WP:CE16206; XO546 isocitrate lyase like Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K02F2.4 Aff_K02F2.4 ulp-5; K02F2.4; 1H387; CE17156; NM_059551; WBGene00006740; WP:CE17156 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K04D7.2 Aff_K04D7.2 K04D7.2; 4K943; CE28240; CE28241; WBGene00010557; WP:CE28240; WP:CE28241 TAT binding homolog 4 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA K07A1.1 Aff_K07A1.1 K07A1.1; 1K158; CE18854; WBGene00010608; WP:CE18854 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K07A1.8 Aff_K07A1.8 ile-1; K07A1.8; K07A1.8.1; K07A1.8.2; 1K186; CE11854; NM_060147; WBGene00002070; WP:CE11854 ile-1 is orthologous to the human gene human ERGIC-53, which when mutated leads to deficiency of coagulation factors V/VIII (OMIM:227300). P58 protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA K07B1.3 Aff_K07B1.3 ucp-4; K07B1.3; 5J815; CE28591; NM_073013; WBGene00006729; WP:CE28591 proton-channel protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated K07B1.4 Aff_K07B1.4 K07B1.4; K07B1.4b.1; K07B1.4b.2; 5J811; CE11882; CE27391; WBGene00019464; WP:CE11882; WP:CE27391 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, McElwee et al 2003 T1 targets of daf-16, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K07C5.1 Aff_K07C5.1 arx-2; K07C5.1; 5K816; CE06111; NM_073256; WBGene00000200; WP:CE06111 actin McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated K07H8.2 Aff_K07H8.2 K07H8.2; K07H8.2b.1; K07H8.2b.2; K07H8.2c.1; K07H8.2c.2; K07H8.2c.3; 4J57; CE18022; CE28593; CE37721; WBGene00019504; WP:CE18022; WP:CE28593; WP:CE37721 Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K08F4.2 Aff_K08F4.2 K08F4.2; 4K892; CE37535; WBGene00010677; WP:CE37535 RNA recognition motif. (aka RRM, RBD, or RNP domain) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated K08H2.6 Aff_K08H2.6 hpl-1; K08H2.6; CE06164; NM_077798; WBGene00001995; WP:CE06164; XN865 The hpl-1 gene encodes a homolog of heterochromatin protein 1 (HP1) that acts to support the activity of HPL-2 in promoting germline function, but that by itself is dispensable for any obvious function in vivo. murine modifier 2 protein like ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K09A9.2 Aff_K09A9.2 rab-14; K09A9.2; K09A9.2.1; K09A9.2.2; CE11974; NM_078171; WBGene00004276; WP:CE11974; XQ224 rab-14 encodes a member of the Rab GTPase family. RAS-related protein Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated K10B3.8 Aff_K10B3.8 gpd-2; K10B3.8; CE07371; NM_076134; WBGene00001684; WP:CE07371; XD732 gpd-2 encodes one of four C. elegans glyceraldehyde-3-phosphate dehydrogenases (GAPDHs); by homology, GPD-2 is predicted to reversibly catalyze the oxidation and phosphorylation of glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate during glycolysis; in C. elegans, GPD-2 and GPD-3 constitute the major GAPDH isoenzymes and are expressed at highest levels during postembryonic development, primarily in the actin-containing A and I zones of body-wall muscle; loss of gpd-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Roy et al 2002 S3 muscle genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 K10D2.6 Aff_K10D2.6 emb-8; K10D2.6; K10D2.6.1; K10D2.6.2; 3G286; CE02018; WBGene00001262; WBGene00019632; WP:CE02018 Uncloned locus required for embryonic viability, for the normal generation of anterior-posterior asymmetry in the early embryo, and for normal P Granule and GLP-1 asymmetry in early embryos. NADPH-cytochrome P450 Custodia et al 2001 T2 Cytochrome P450, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph K11D12.5 Aff_K11D12.5 K11D12.5; 5F508; CE12134; WBGene00019645; WP:CE12134 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol K11G12.5 Aff_K11G12.5 K11G12.5; CE02827; WBGene00019656; WP:CE02827; XH342 mitochondrial 2-oxoglutartae McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 M01B12.3 Aff_M01B12.3 arx-7; M01B12.3; 1D638; CE18061; NM_058698; WBGene00000205; WP:CE18061 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated M01B12.4 Aff_M01B12.4 M01B12.4; M01B12.4a.1; M01B12.4a.2; CE29982; CE30554; CE37031; NM_170839; NM_170840; NM_171834; WBGene00019697; WP:CE29982; WP:CE30554; WP:CE37031 ViswanathanM et al 2005 S2 sir-2.1 regulated M01E11.6 Aff_M01E11.6 klp-15; M01E11.6; 1G146; CE12298; NM_059232; WBGene00002225; WP:CE12298 kinesins Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories M01F1.8 Aff_M01F1.8 M01F1.8; 3E590; CE33806; CE34206; WBGene00010814; WP:CE33806; WP:CE34206 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated M01H9.3 Aff_M01H9.3 M01H9.3; M01H9.3a.1; M01H9.3a.2; 4F234; CE28614; CE28615; CE37722; WBGene00019719; WP:CE28614; WP:CE28615; WP:CE37722 Murphy et al 2003 Fig2 Class1 elongate lifespan, Shen et al 2005 T1 hif-1 depend hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 M106.2 Aff_M106.2 M106.2; 2L132; CE30680; WBGene00010910; WP:CE30680 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated R03D7.1 Aff_R03D7.1 R03D7.1; 2L219; CE01609; WBGene00010988; WP:CE01609 R03D7.1 is orthologous to the human gene METHIONINE SYNTHASE (MTR; OMIM:156570), which when mutated leads to disease. 5-methyltetrahydrofolate-homocysteine methyltransferase ViswanathanM et al 2005 S2 daf-16 Resveratrol R05D11.3 Aff_R05D11.3 CE-NTF2; ran-4; R05D11.3; R05D11.3.1; R05D11.3.2; 1J167; CE06238; NM_059921; WBGene00004305; WP:CE06238 ran-4 encodes a ortholog of NUCLEAR TRANSPORT FACTOR 2 (NTF2) from S. cerevisiae and metazoa, which is predicted to interact with nucleoporins and to promote transport of RAN-1(+GDP) into the nucleus; RAN-4/NTF2 proteins are paralogous to the N-terminal domain of RasGAP SH3 binding proteins such as Drosophila RASPUTIN, and to delta-5-3-ketosteroid isomerases, while having no homology to Ran proteins per se; RAN-4 is essential for early embryogenesis; in mass RNAi assays, ran-4 is needed for embryonic viability, normally rapid growth, fertility, and normal pronuclear envelopes in the embryo. nuclear transport factor 2 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA R05D11.6 Aff_R05D11.6 R05D11.6; 1J173; CE32473; WBGene00011034; WP:CE32473 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen R05F9.10 Aff_R05F9.10 sgt-1; R05F9.10; 2F192; CE04813; WBGene00019893; WP:CE04813 TPR domain repeats McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated R06C7.5 Aff_R06C7.5 R06C7.5; R06C7.5b.1; R06C7.5b.2; 1H824; CE06248; CE32476; WBGene00011064; WP:CE06248; WP:CE32476 The R06C7.5 gene encodes an ortholog of the human gene ADSL, which when mutated leads to adenylosuccinate lyase deficiency (OMIM:103050). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated R06F6.4 Aff_R06F6.4 R06F6.4; 2L84; CE16303; WBGene00011068; WP:CE16303 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated R07B7.2 Aff_R07B7.2 R07B7.2; 5M540; CE38533; WBGene00011087; WP:CE38533 Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol R07E4.4 Aff_R07E4.4 mig-23; R07E4.4; R07E4.4.1; R07E4.4.2; CE28748; NM_076593; WBGene00003254; WP:CE28748; XG566 guanosine-diphosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated R08D7.8 Aff_R08D7.4 R08D7.8; CE33293; WBGene00011148; WP:CE33293 Reinke et al 2004, wt herm vs wt male enriched gen R107.2 Aff_R107.2 R107.2; 3K134; CE23917; WBGene00011298; WP:CE23917 Uncharacterized protein family UPF0031 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R107.5 Aff_R107.5 R107.5; 3K142; CE00300; CE23918; WBGene00011300; WP:CE00300; WP:CE23918 ViswanathanM et al 2005 S2 daf-16 Resveratrol R10E11.8 Aff_R10E11.8 vha-1; R10E11.8; R10E11.8.1; R10E11.8.2; R10E11.8.3; 3K871; CE06291; NM_066764; WBGene00006910; WP:CE06291 vha-1 encodes a 16-kDa proteolipid of the vacuolar-type H+-ATPase (V-ATPase) and is required for embryogenesis and for oocyte ovulation, based on RNAi analysis; expressed in the excretory cells and the rectum of adult animals as well as in a pair of cells posterior to the anus. ATP synthase subunit C (2 domains) Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C R10H10.1 Aff_R10H10.1 lpd-8; R10H10.1; R10H10.1.1; R10H10.1.2; 4L153; CE06292; NM_069516; WBGene00003064; WP:CE06292 lpd-8 encodes a homolog of human and mouse HIRA-interacting protein-5; LPD-8 has C-terminal similarity to a domain of NifU observed in thioredoxin-like proteins and domains (COG0694), and is predicted to be mitochondrial on phylogenetic grounds. Yeast hypothetical protein YKE0 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated R13A5.7 Aff_R13A5.7 R13A5.7; 3I656; CE30389; WBGene00020050; WP:CE30389 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated R13D11.3 Aff_R13D11.3 R13D11.3; 5B293; CE28769; WBGene00020057; WP:CE28769 Jones et al 2001 Dauer specific genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit R53.7 Aff_R53.7 R53.7; R53.7a.1; R53.7a.2; 2K262; CE03577; CE32921; WBGene00011276; WP:CE03577; WP:CE32921 protein kinase like protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 R74.8 Aff_R74.8 R74.8; 3F297; CE35361; CE37038; WBGene00011282; WP:CE35361; WP:CE37038 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T02G5.9 Aff_T02G5.9 krs-1; T02G5.9; T02G5.9c.1; T02G5.9c.2; T02G5.9c.3; T02G5.9c.4; 2H362; CE04861; CE28247; CE38540; NM_063052; NM_063053; WBGene00002238; WP:CE04861; WP:CE28247; WP:CE38540 lysyl-tRNA synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 T03D8.2 Aff_T03D8.2 T03D8.2; 5V309; CE18920; WBGene00011391; WP:CE18920 Ribosomal protein S12 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T03F1.1 Aff_T03F1.1 T03F1.1; 1E443; CE13096; WBGene00020184; WP:CE13096 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T03F1.8 Aff_T03F1.8 T03F1.8; 1E428; CE29460; WBGene00020190; WP:CE29460 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. guanylate kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T04A8.7 Aff_T04A8.7 T04A8.7; CE01076; CE33539; NM_065560; NM_181902; WBGene00011409; WP:CE01076; WP:CE33539 T04A8.7 is orthologous to human GLUCOSIDASE, ACID BETA (GBA; OMIM:606463), which when mutated leads to Gaucher disease. Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T04C10.2 Aff_T04C10.2 epn-1; T04C10.2; CE26820; CE26821; NM_078057; NM_078058; WBGene00001329; WP:CE26820; WP:CE26821; XP436 Yeast hypothetical protein L8167.6 like ViswanathanM et al 2005 S2 sir-2.1 regulated T04D1.3 Aff_T04D1.3 unc-57; T04D1.3; 1F243; CE37042; CE39765; NM_059023; WBGene00006791; WP:CE37042; WP:CE39765 unc-57 encodes an ortholog of endophilin A that is required for synaptic vesicle endocytosis; UNC-57 is expressed in all neurons, at synapses and neuromuscular junctions, and (weakly) in the spermetheca; like other endophilins, UNC-57 has a large BAR domain, an N-terminal coiled-coil domain within the BAR domain, and a C-terminal SH3 domain; UNC-57 protein is necessary for proper localization of UNC-26 (synaptojanin) protein, which in turn is needed for endocytosis; unc-57 and unc-26 mutants are morphologically, ultrastructurally, and electrophysiologically similar both to one another and to double mutants, indicating that UNC-57 and UNC-26 act in a single genetic pathway. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T04F8.1 Aff_T04F8.1 T04F8.1; CE03614; WBGene00011440; WP:CE03614; XM278 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T05A6.2 Aff_T05A6.2 cki-2; T05A6.2; 2I109; CE18928; CE31824; NM_063241; WBGene00000517; WP:CE18928; WP:CE31824 cki-2 encodes a cyclin-dependent kinase (CDK) inhibitor of the CIP/KIP family, orthologous to human CDKN1C (OMIM:600856, which when mutated leads to Beckwith-Wiedemann syndrome) that may play a role in cell cycle progression during embryogenesis; CKI-2 interacts with PCN-1, a proliferating cell nuclear antigen homolog, SMO-1, a SUMO (ubiquitin related) homolog, and the RING domain-containing protein C06A5.9. posterior sex combs protein-like domain Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated T05E11.5 Aff_T05E11.5 imp-2; T05E11.5; 4L882; CE06364; NM_069678; WBGene00011481; WP:CE06364 Yeast YKK0 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T05G5.7 Aff_T05G5.7 T05G5.7; 3K849; CE00319; WBGene00011501; WP:CE00319 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E T05H10.1 Aff_T05H10.1 T05H10.1; 2I337; CE32928; WBGene00011507; WP:CE32928 ubiquitin carboxyl-terminal hydrolase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories T06D8.5 Aff_T06D8.5 T06D8.5; T06D8.5.1; T06D8.5.2; T06D8.5.3; 2L522; CE02326; WBGene00011526; WP:CE02326 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. YER141W McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 T06E4.3 Aff_T06E4.3 Ce-atl1; atl-1; T06E4.3; 5K116; CE25103; CE28250; NM_073086; WBGene00000226; WP:CE25103; WP:CE28250 The atl-1 gene encodes a large, 2514-residue protein of the ATM family, homologous to human AT (OMIM:208900, mutated in ataxia telangiectasia); the C-terminal sequence of ATL-1 contains a PI-3 kinase-like domain; ATL-1 is required for survival through early embryogenesis and normal chromosomal segregation; atl-1 is expressed in both the mitotic and meiotic cells of adult gonads. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes T07E3.3 Aff_T07E3.3 T07E3.3; 3H993; CE01384; WBGene00020314; WP:CE01384 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched T08D2.5 Aff_T08D2.I T08D2.5; T08D2.I; CE21171; WBGene00011610; WP:CE21171; XA806 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen T09A12.4 Aff_T09A12.4 nhr-66; T09A12.4; T09A12.4a.1; T09A12.4a.2; T09A12.4a.3; T09A12.4a.4; T09A12.4d.1; T09A12.4d.2; 4I992; CE31061; CE31062; CE31063; CE37723; NM_171396; NM_171397; NM_171398; WBGene00003656; WP:CE31061; WP:CE31062; WP:CE31063; WP:CE37723 nhr-66 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain; expression studies using GFP fusions indicate that nhr-66 is expressed in several neuronal and nonneuronal cells; microarray analysis indicates that expression of nhr-66 in neurons and seam cells is upregulated in response to exposure to cholesterol. Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma T10C6.6 Aff_T10C6.6 T10C6.6; T10C6.6a.1; T10C6.6a.2; T10C6.6a.3; T10C6.6b.1; T10C6.6b.2; T10C6.6b.3; T10C6.6b.4; T10C6.6b.5; 5Q507; CE16381; CE23965; WBGene00011688; WP:CE16381; WP:CE23965 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ViswanathanM et al 2005 S2 sir-2.1 regulated T12D8.2 Aff_T12D8.2 drr-2; T12D8.2; T12D8.2.1; T12D8.2.2; 3O734; CE16399; WBGene00011730; WP:CE16399 RNA recognition motif. (aka RRM, RBD, or RNP domain) Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T13F2.6 Aff_T13F2.6 T13F2.6; 4K545; CE13629; WBGene00011746; WP:CE13629 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T14B4.1 Aff_T14B4.1 T14B4.1; 2H31; CE32068; WBGene00020498; WP:CE32068 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. rRNA methylase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T19A5.1 Aff_T19A5.1 T19A5.1; T19A5.1.1; T19A5.1.2; 5J441; CE07509; WBGene00020553; WP:CE07509 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T19B10.8 Aff_T19B10.8 T19B10.8; 5L723; CE06462; WBGene00011835; WP:CE06462 Yeast hyptothetical protein YFC5 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 T20D3.8 Aff_T20D3.8 T20D3.8; 4K106; CE23990; WBGene00011860; WP:CE23990 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T20F5.2 Aff_T20F5.2 pbs-4; T20F5.2; 1E477; CE13818; NM_058860; WBGene00003950; WP:CE13818 pbs-4 encodes a B-type subunit of the 26S proteasome's 20S protease core particle; by homology, PBS-4 is predicted to function in ATP/ubiquitin-dependent nonlysosomal protein degradation; loss of pbs-4 activity via RNAi indicates that, in C. elegans, PBS-4 is required for embryonic, germline, and larval development. peptidase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T21B10.3 Aff_T21B10.3 T21B10.3; 2J227; CE23993; WBGene00011885; WP:CE23993 Jones et al 2001 Non dauer genes P<0.05, Lund et al 2002 Fig1 aging-regulated genes, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Romagnolo et al 2002 Fig3b Unkown T21B10.4 Aff_T21B10.4 T21B10.4; 2J235; CE03686; WBGene00011886; WP:CE03686 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T21B10.5 Aff_T21B10.5 T21B10.5; 2J230; CE23994; WBGene00011887; WP:CE23994 transcriptional repressor like Jones et al 2001 Dauer specific genes P<0.05, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset T21B10.7 Aff_T21B10.7 T21B10.7; T21B10.7.1; T21B10.7.2; 2J219; CE16437; WBGene00011889; WP:CE16437 t-complex protein 1 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T22B11.5 Aff_T22B11.5 T22B11.5; 4F462; CE28486; WBGene00020679; WP:CE28486 The T22B11.5 gene encodes an ortholog of the human gene OGDH, which when mutated leads to alpha-ketoglutarate deficiency (OMIM:203740); the T22B11.5 protein is predicted to be mitochondrial with 68% accuracy. 2-oxoglutarate dehydrogenase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T22D1.9 Aff_T22D1.9 rpn-1; T22D1.9; T22D1.9.1; T22D1.9.2; 4H672; CE17253; NM_068663; WBGene00004458; WP:CE17253 rpn-1 encodes a non-ATPase subunit of the 26S proteasome's 19S regulatory particle (RP) base subcomplex; RPN-1 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding and recognition of protein substrates and/or recycling of ubiquitin moieties during protein degradation. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated T23D8.7 Aff_T23D8.7 T23D8.7; 1K569; CE14058; WBGene00011945; WP:CE14058 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T23G11.2 Aff_T23G11.2 gna-2; T23G11.2; T23G11.2.1; T23G11.2.2; 1I277; CE16458; NM_059743; WBGene00001647; WP:CE16458 gna-2 encodes a member of the phosphoglucosamine acetyltransferase protein family that affects cytokinesis, embryonic viability, and fertility. Acetyltransferase (GNAT) family (2 domains) Jones et al 2001 Non dauer genes P<0.05, Jones et al 2001 T3 20 most abundant Mixed-stage, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T24D1.4 Aff_T24D1.4 tag-179; T24D1.4; 1K538; CE14168; WBGene00007043; WBGene00011987; WP:CE14168 Yeast DIE2 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T24H10.4 Aff_T24H10.4 T24H10.4; 2J401; CE35030; WBGene00012002; WP:CE35030 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T27E9.3 Aff_T27E9.3 cdk-5; T27E9.3; 3O554; CE21213; NM_067382; WBGene00000407; WP:CE21213 cdk-5 encodes a putative homolog of cyclin dependent kinase 5 that affects pronuclear migration and rotation in one-cell embryos and may affect neuronal development; expressed in neurons. serine/threonine kinase (CDC2/CDKX subfamily) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E T28F3.3 Aff_F26D10.5 tag-230; T28F3.3; 4S230; CE36329; WBGene00012129; WBGene00044067; WP:CE36329 Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated W01A8.5 Aff_W01A8.5 W01A8.5; 1H647; CE06535; WBGene00012167; WP:CE06535 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated W02D3.4 Aff_W02D3.4 W02D3.4; 1H296; CE14424; WBGene00020933; WP:CE14424 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 W02F12.3 Aff_W02F12.3 W02F12.3; 5H183; CE14476; WBGene00020948; WP:CE14476 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated W02F12.5 Aff_W02F12.5 W02F12.5; W02F12.5.1; W02F12.5.2; W02F12.5.3; 5H188; CE31083; WBGene00020950; WP:CE31083 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. dihydrolipoamide succinyltransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated W05B10.1 Aff_W05B10.1 W05B10.1; 5N140; CE06544; WBGene00012276; WP:CE06544 Core histones H2A, H2B, H3 and H4 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated W05H7.3 Aff_W05H7.3 sedl-1; W05H7.3; CE14652; NM_075871; WBGene00021046; WP:CE14652; XC58 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol W06E11.4 Aff_W06E11.4 W06E11.4; 3B254; CE30118; WBGene00021063; WP:CE30118 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated W07A12.7 Aff_W07A12.7 tag-323; W07A12.7; 2J453; CE20163; WBGene00012324; WP:CE20163 Jones et al 2001 Dauer specific genes P<0.05, Jones et al 2001 T3 20 most abundant Dauer, Shen et al 2005 T1 hif-1 depend hypoxia, Wang et al 2003 S6 removed genes of contamination, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit W08E12.7 Aff_W08E12_12.E W08E12.7; W08E12.7.1; W08E12.7.2; W08E12.7.3; W08E12.E; 4E61; CE21275; WBGene00021088; WP:CE21275 peptidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 W08E3.3 Aff_W08E3.3 tag-210; W08E3.3; 1N935; CE14708; WBGene00012344; WBGene00044075; WP:CE14708 GTP-binding protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated W10D9.4 Aff_W10D9.4 W10D9.4; 2A752; CE14792; WBGene00021132; WP:CE14792 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y113G7B.23 Aff_Y113G7B.L psa-1; Y113G7B.23; 5U710; CE25208; NM_075505; WBGene00004203; WP:CE25208 psa-1 encodes an ortholog of SWI3, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-1 is probably required during mitosis of the T cells for asymmetric cell division, and in addition, is required for embryonic and larval development, as well as normal levels of fertility; psa-1 exhibits strong genetic interactions with lin-35/Rb, as psa-1 larval lethality and sterility at 20 degrees C are greatly enhanced in lin-35;psa-1 double mutants. SWI/SNF protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y17G7B.4 Aff_Y17G7B.4 Y17G7B.4; 2M287; CE19037; WBGene00012460; WP:CE19037 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y17G7B.7 Aff_Y17G7B.7 tpi-1; Y17G7B.7; Y17G7B.7.1; Y17G7B.7.2; 2M328; CE19040; NM_064162; TPI; WBGene00006601; WP:CE19040 tpi-1 is orthologous to the human gene TRIOSEPHOSPHATE ISOMERASE 1 (TPI1; OMIM:190450), which when mutated leads to disease. Triosephosphate isomerase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y18D10A.11 Aff_Y18D10A.K Y18D10A.11; 1N454; CE21407; WBGene00012481; WP:CE21407 Jones et al 2001 Non dauer genes P<0.05, Jones et al 2001 T3 20 most abundant Mixed-stage, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y18D10A.20 Aff_Y18D10A.T pfn-1; Y18D10A.20; Y18D10A.20.1; Y18D10A.20.2; Y18D10A.T; 1N515; CE21418; NM_060857; WBGene00003989; WP:CE21418 Profilins Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y34D9A.1 Aff_Y34D9A_151.C Y34D9A.1; 1B494; CE27249; WBGene00021327; WP:CE27249 Bishop et al 2004 T1 Upregulated in vhl-1 vs WT, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y37A1B.2 Aff_Y37A1B.3 lst-4; Y37A1B.2; 4O826; CE19071; CE32245; CE32246; CE32247; NM_070292; NM_070293; NM_070294; NM_182290; WBGene00003086; WP:CE19071; WP:CE32245; WP:CE32246; WP:CE32247 Src homology domain 3 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y37D8A.13 Aff_Y37D8A.13 adm-1; max-3; unc-71; Y37D8A.13; 3N972; CE20217; NM_067279; WBGene00006804; WP:CE20217 unc-71 encodes an ADAM, a disintegrin and metalloprotease-containing transmembrane protein that is a member of the metzincin superfamily of proteases; UNC-71 is required non-cell autonomously for motor axon guidance and sex myoblast migration; UNC-71 does not appear to have an active metalloprotease domain, but functions with UNC-6/netrin and integrins INA-1/PAT-3 to provide guidance cues during axonal migration; UNC-71 is expressed in a restricted pattern in the excretory and excretory gland cells, some head neurons, the sphincter muscles, and hypodermal cells surrounding the vulva. Disintegrin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E Y37E11B.3 Aff_Y37E11B.3 Y37E11B.3; 4E346; CE19613; WBGene00021376; WP:CE19613 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y38A8.2 Aff_Y38A8.2 pbs-3; Y38A8.2; Y38A8.2.1; Y38A8.2.2; 2F244; CE07571; NM_062512; WBGene00003949; WP:CE07571 pbs-3 encodes a B-type subunit of the 26S proteasome's 20S protease core particle; by homology, PBS-3 is predicted to function in ATP/ubiquitin-dependent nonlysosomal protein degradation; loss of pbs-3 activity via large-scale RNAi screens indicates that, in C. elegans, PBS-3 is required for embryonic and germline development, movement, normal body coloration, and normal body morphology. Peptidase Golden et al 2004, N2 vs daf-2 different genes at , Golden et al 2004, N2 vs daf-2 age different gene, Golden et al 2004, N2 differentially expressed gen, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y38F2AR.2 Aff_Y38F2A_6126.I Y38F2AR.2; Y38F2AR.2.1; Y38F2AR.2.2; Y38F2A_6126.I; 4D153; CE21634; WBGene00021420; WP:CE21634 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y39A1A.3 Aff_Y39A1A.3 Y39A1A.3; 3L682; CE19121; WBGene00012643; WP:CE19121 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y39B6A.13 Aff_Y39B6.S Y39B6A.13; Y39B6B.S; 5T592; CE21694; WBGene00012675; WP:CE21694 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E Y39B6A.16 Aff_Y39B6.B Y39B6A.16; Y39B6B.B; CE29858; WBGene00012678; WP:CE29858 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes Y39E4B.2 Aff_Y39E4B.K Y39E4B.2; Y39E4B.K; 3O256; CE21714; WBGene00012715; WP:CE21714 Y39G10AR.21 Aff_Y39G10A_246.B Y39G10AR.21; Y39G10AR.21.1; Y39G10AR.21.2; 1C879; CE28981; WBGene00021476; WP:CE28981 Y39G10AR.21 is orthologous to the human gene SIMILAR TO RIKEN CDNA 2810405F18 GENE (FAAH; OMIM:602935), which when mutated leads to disease. Y39G8B.2 Aff_Y39G8B.D Y39G8B.2; 2O264; CE24244; WBGene00012723; WP:CE24244 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Shen et al 2005 T1 hif-1indepen hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated Y40B10A.8 Aff_Y40B10A_107.B nhr-86; Y40B10A.8; 5C540; CE31110; NM_071160; WBGene00003676; WP:CE31110 Y41E3.7 Aff_Y41E3.7 Y41E3.7; Y41E3.7c.1; Y41E3.7c.2; 4P789; CE18375; CE24268; CE39435; WBGene00012765; WP:CE18375; WP:CE24268; WP:CE39435 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y42G9A.6 Aff_Y42G9A_141.B Y42G9A.6; Y42G9A.6b.1; Y42G9A.6b.2; Y42G9A.A; Y42G9A.B; 3H232; CE33223; CE39827; WBGene00021535; WP:CE33223; WP:CE39827 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, herm soma enriched genes Y43E12A.1 Aff_Y43E12A.1 cyb-2.1; Y43E12A.1; 4L751; CE28122; NM_069646; WBGene00000866; WP:CE28122 cyclin B Jiang et al 2001 Fig2 cyclin-genes, McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y43F8C.12 Aff_Y116F11.ZZ8 mrp-7; Y43F8C.12; 5U161; CE32017; NM_075411; WBGene00003413; WP:CE32017 mrp-7 encodes a predicted ATP-binding cassette (ABC) transporter that is a member of the ABCC subfamily of ABC transporters that includes the multidrug resistance-associated proteins and the cystic fibrosis transmembrane conductance regulator; by homology, MRP-7 is predicted to function as an ATP-dependent organic anion transporter that transports molecules across the plasma membrane into the extracellular space; at present, the precise role of MRP-7 in C. elegans development and/or behavior is not yet known. ABC transporter ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y43F8C.14 Aff_Y116F11.ZZ10 ani-3; Y43F8C.14; 5U173; CE21912; NM_075413; WBGene00012835; WP:CE21912 PH (pleckstrin homology) domain Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y43F8C.8 Aff_Y116F11.ZZ6 Y43F8C.8; 5U119; CE21906; WBGene00012830; WP:CE21906 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y47G6A.2 Aff_Y47G6A_232.A inx-22; Y47G6A.2; Y47G6A.2.1; Y47G6A.2.2; 1E179; CE39849; NM_058785; WBGene00002144; WP:CE39849 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E Y47G6A.25 Aff_Y47G6A_240.C Y47G6A.25; Y47G6A_240.C; 1E176; CE34403; WBGene00021649; WP:CE34403 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E Y48C3A.10 Aff_Y48C3A.K Y48C3A.10; 2N629; CE22143; WBGene00012992; WP:CE22143 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y49A3A.2 Aff_Y49A3A.B, Aff_Y49A3A.C phi-51; vha-13; Y49A3A.2; Y49A3A.2.1; Y49A3A.2.2; Y49A3A.2.3; Y49A3A.2.4; Y49A3A.B; Y49A3A.C; CE22210; NM_074158; WBGene00013025; WP:CE22210 ATP synthase alpha and beta subunits ; ATP synthase ab C terminal McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y4C6A.3 Aff_Y4C6A.G Y4C6A.3; 4G216; CE21299; WBGene00021153; WP:CE21299 zinc finger protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated Y54E10A.12 Aff_Y54E10A_150.B Y54E10A.12; 1D762; CE24441; WBGene00021832; WP:CE24441 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated Y54E10BR.5 Aff_Y54E10B_159.D Y54E10BR.5; 1D598; CE22466; WBGene00021844; WP:CE22466 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y54G9A.5 Aff_Y54G9A.5 Y54G9A.5; 2O13; CE20321; WBGene00013208; WP:CE20321 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y56A3A.22 Aff_Y56A3A.T Y56A3A.22; Y56A3A.T; 3N13; CE26190; WBGene00013239; WP:CE26190 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57E12AL.1 Aff_Y57E12_242.B Y57E12AL.1; Y57E12AL.1a.1; Y57E12AL.1a.2; 5H541; CE29890; CE29891; WBGene00021956; WP:CE29890; WP:CE29891 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57G11C.13 Aff_Y57G11C.13 Y57G11C.13; 4P563; CE14950; WBGene00013309; WP:CE14950 ADP-ribosylation factor Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57G11C.15 Aff_Y57G11C.15 Y57G11C.15; Y57G11C.15.1; Y57G11C.15.2; Y57G11C.15.3; 4P588; CE14954; WBGene00013311; WP:CE14954 protein transport protein SEC61 alpha subunit McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y63D3A.4 Aff_Y63D3A.4 Y63D3A.4; 1O690; CE20335; WBGene00013405; WP:CE20335 Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated Y67D8A.1 Aff_Y67D8A_386.A Y67D8A.1; Y67D8A.1.1; Y67D8A.1.2; 4E15; CE31660; WBGene00022058; WP:CE31660 Y67D8A.1 is orthologous to the human gene PHOSPHORYLASE KINASE, BETA SUBUNIT (PHKB; OMIM:172490), which when mutated leads to glycogen storage disease. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y69A2AR.18 Aff_Y69A2A_2991.A Y69A2AR.18; Y69A2AR.18a.1; Y69A2AR.18a.2; Y69A2AR.18a.3; Y69A2AR.18b.1; Y69A2AR.18b.2; Y69A2AR.18c.1; Y69A2AR.18c.2; 4D261; CE27514; CE29133; CE33241; WBGene00022089; WP:CE27514; WP:CE29133; WP:CE33241 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y6B3B.9 Aff_Y6B3B.9 Y6B3B.9; 1O328; CE34133; WBGene00012393; WP:CE34133 Y6D11A.2 Aff_Y6D11A_150.A arx-4; tag-286; Y6D11A.2; 3B481; CE30060; WBGene00021170; WP:CE30060 Y71F9AL.16 Aff_Y71F9A_294.A arx-1; Y71F9AL.16; Y71F9AL.F; 1D452; CE25554; NM_058665; WBGene00000199; WP:CE25554 actin McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y71F9B.2 Aff_Y71F9B_275.B, Aff_Y71F9B_297.D Y71F9B.2; Y71F9B.O; 1D303; CE28809; WBGene00022126; WP:CE28809 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y71F9B.3 Aff_Y71F9B_275.A Y71F9B.3; Y71F9B.3.1; Y71F9B.3.2; 1D299; CE24624; WBGene00022127; WP:CE24624 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y75B8A.16 Aff_Y75B8A.S Y75B8A.16; Y75B8A.S; 3N313; CE24667; WBGene00013551; WP:CE24667 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y75B8A.30 Aff_Y75B8A.NN pph-4.1; Y75B8A.30; 3N436; CE23041; NM_067202; WBGene00004085; WP:CE23041 Ser/Thr protein phosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y75D11A.3 Aff_Y75D11A_91.A Y75D11A.3; Y75D11A.C; CE23050; WBGene00022292; WP:CE23050; XC364 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, IVb male soma enriched genes Y76A2B.5 Aff_Y76A2B.5 Y76A2B.5; 3O636; CE19277; WBGene00013577; WP:CE19277 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y79H2A.6 Aff_Y79H2A.F arx-3; Y79H2A.6; 3N122; CE24672; NM_067169; WBGene00000201; WP:CE24672 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y87G2A.7 Aff_Y87G2A.L Y87G2A.7; 1O167; CE23136; WBGene00013596; WP:CE23136 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y87G2A.8 Aff_Y87G2A.M gpi-1; Y87G2A.8; Y87G2A.8a.1; Y87G2A.8a.2; Y87G2A.8a.3; 1O173; CE24687; CE36253; WBGene00013597; WP:CE24687; WP:CE36253 Y87G2A.8 is orthologous to the human gene GLUCOSE PHOSPHATE ISOMERASE (GPI; OMIM:172400), which when mutated leads to disease. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y95B8A.11 Aff_Y95B8A_84.B Y95B8A.11; 1B354; CE34441; WBGene00022390; WP:CE34441 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol ZC155.1 Aff_ZC155.1 nex-1; ZC155.1; ZC155.1.1; ZC155.1.2; ZC155.1.3; 3G315; CE01431; NM_065708; WBGene00003588; WP:CE01431 nex-1 encodes an annexin, a member of a family of calcium-dependent phospholipid binding proteins; NEX-1 is required for efficient engulfment of apoptotic cell corpses in the pharynx, and may also function in other membrane fusion events, such as exocytosis; NEX-1 in vitro can bind phosphatidylserine, phosphatidylinositol, heparin, heparan sulfate, and chondroitin sulfate; NEX-1 is expressed in the pharynx, hypodermal cells, the vulva, the uterus, the spermathecal valve, and yolk granules of maturing oocytes. ViswanathanM et al 2005 S2 sir-2.1 regulated ZC376.5 Aff_ZC376.5 trm-1; ZC376.5; 5O664; CE15201; NM_074112; Trm1; WBGene00006613; WP:CE15201 N2,N2-dimethylguanosine tRNA methyltransferase Jones et al 2001 Non dauer genes P<0.05, Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA ZC376.7 Aff_ZC376.7 ZC376.7; ZC376.7a.1; ZC376.7a.2; ZC376.7b.1; ZC376.7b.2; 5O677; CE15205; CE32033; CE38576; WBGene00013878; WP:CE15205; WP:CE32033; WP:CE38576 DNA binding domain ViswanathanM et al 2005 S2 sir-2.1 regulated ZC434.8 Aff_ZC434.8 ZC434.8; 1K924; CE06583; WBGene00013894; WP:CE06583 arginine kinase ViswanathanM et al 2005 S2 sir-2.1 regulated ZC53.1 Aff_ZC53.1 ZC53.1; CE35813; WBGene00022508; WP:CE35813; XC526 ZK1058.1 Aff_ZK1058.1 mmcm-1; ZK1058.1; ZK1058.1.1; ZK1058.1.2; 3E994; CE30404; WBGene00014202; WP:CE30404 ZK1058.1 is orthologous to the human gene METHYLMALONYL CoA MUTASE (MUT; OMIM:251000) which when mutated leads to the mut class of methylmalonic acidemia (methylmalonicaciduria). Methylmalonyl-coA mutase ViswanathanM et al 2005 S2 sir-2.1 regulated ZK154.6 Aff_ZK154.6 ZK154.6; CE28178; CE35816; WBGene00022668; WP:CE28178; WP:CE35816; XI410 ZK177.8 Aff_ZK177.8 ZK177.8; ZK177.8b.1; ZK177.8b.2; 2F800; CE02097; CE07618; WBGene00022673; WP:CE02097; WP:CE07618 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK353.7 Aff_ZK353.7 ZK353.7; 3J492; CE00391; WBGene00022702; WP:CE00391 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK370.7 Aff_ZK370.7 ZK370.7; 3J836; CE29642; WBGene00022721; WP:CE29642 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK381.4 Aff_ZK381.4 pgl-1; ZK381.4; ZK381.4a.1; ZK381.4a.2; 4H740; CE07628; CE25689; NM_068676; WBGene00003992; WP:CE07628; WP:CE25689 pgl-1 encodes a predicted RNA-binding protein that contains a number of C-terminal RGG box motifs; PGL-1 activity is required at high temperatures during midlarval to adult stages for postembryonic germline development and hence fertility, and also for proper formation of the germline-specific P granules; PGL-1 protein, supplied maternally and embryonically, is a constitutive P granule component and thus, its localization is cytoplasmic in oocytes and early embryos, while perinuclear in the germline blastomere P4 and proliferating germ cells of larvae and adults; pgl-1 mRNA is expressed exclusively in hermaphrodite and male germlines and is detectable at all stages of development, with highest levels seen in adults; PGL-1 localization to P granules requires wild-type activity of the predicted germline helicase GLH-1. Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK418.5 Aff_ZK418.5 ZK418.5; 3I162; CE28189; WBGene00022734; WP:CE28189 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA ZK546.2 Aff_ZK546.16 ZK546.2; 2F237; CE07632; CE36076; CE36077; WBGene00022759; WP:CE07632; WP:CE36076; WP:CE36077 Adenylate cyclase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK550.3 Aff_ZK550.3 ZK550.3; ZK550.3.1; ZK550.3.2; 4S197; CE37464; WBGene00013997; WP:CE37464 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA ZK632.4 Aff_ZK632.4 ZK632.4; 3K896; CE36417; WBGene00014013; WP:CE36417 ZK632.4 is orthologous to the human gene PHOSPHOMANNOSE ISOMERASE (MPI; OMIM:154550), which when mutated leads to disease. Mannose 6-phosphate isomerase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK792.6 Aff_ZK792.6 let-60; lin-34; ZK792.6; 4M454; CE03827; NM_069812; WBGene00002335; WP:CE03827 The let-60 gene encodes a member of the GTP-binding RAS protooncogene family that affects viability, vulval development, spicule development, germ line meiotic progression, posterior development of the hypodermis, and chemotaxis; it acts genetically downstream of let-23 with respect to vulval development and upstream of the MAPK pathway with respect to chemotaxis, and is expressed in neural, muscle, and hypodermal lineages. LET-60 RAS protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b signaling ZK809.5 Aff_ZK809.5 ZK809.5; 4M423; CE28874; CE33911; WBGene00014087; WP:CE28874; WP:CE33911 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK829.4 Aff_ZK829.4 ZK829.4; ZK829.4.1; ZK829.4.2; ZK829.4.3; ZK829.4.4; 4M719; CE06652; WBGene00014095; WP:CE06652 ZK829.4 is orthologous to the human gene GLYCINE DECARBOXYLASE PRECURSOR (GLUD1; OMIM:238300), which when mutated leads to disease. glutamate dehydrogenase Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK829.7 Aff_ZK829.7 ZK829.7; 4M724; CE18467; WBGene00014096; WP:CE18467 alcohl dehydrogenase like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK856.11 Aff_ZK856.11 ZK856.11; 5K684; CE06668; WBGene00014112; WP:CE06668 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK945.2 Aff_ZK945.2 pas-7; ZK945.2; ZK945.2.1; ZK945.2.2; 2K388; CE36420; NM_063776; WBGene00003928; WP:CE36420 proteasome component (A-type) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Proteases, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA ZK973.3 Aff_ZK973_14.K ZK973.3; ZK973.3.1; ZK973.3.2; 1E937; CE24749; WBGene00022832; WP:CE24749 phosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0