Baugh et al 2003, subclass E_53min, 865 genes Gene list file name: Baugh2003_classEpi_53min.txt Type of gene identifier: Affymetrix custom chip Description: Baugh et al 2005, Supplymental Dataset, subclass E_53min Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations AC3.3 Aff_AC3.3 abu-1; pqn-1; AC3.3; 5K858; CE05133; NM_073266; WBGene00000024; WP:CE05133 abu-1 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-1 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-1 may help protect the organism from damage by improperly folded nascent protein. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 Fig6A Resveratrol, ViswanathanM et al 2005 S2 daf-16 Resveratrol AFF_C10B5.2 Aff_C10B5.2 AFF_C25A1.6 Aff_C25A1.6 AFF_C46A5.6 Aff_C46A5.6 AFF_F07H5.5 Aff_F07H5.5 AFF_F17C11.1 Aff_F17C11.1 AFF_F22E5.15 Aff_F22E5.15 AFF_F23A7.6 Aff_F23A7.6 AFF_F36H5.7 Aff_F36H5.7 AFF_F40F12.2 Aff_F40F12.2 AFF_F45E6.5 Aff_F45E6.5 AFF_F52G2.2 Aff_F52G2.2 AFF_H20H17.1 Aff_H20H17.1 AFF_K02B12.5 Aff_K02B12.5 AFF_K08B12.3 Aff_K08B12.3 AFF_K11D12.7 Aff_K11D12.7 AFF_M03A1.3 Aff_M03A1.3 AFF_R06A4.3 Aff_R06A4.3 AFF_R07G3.4 Aff_R07G3.4 AFF_T05H4.8 Aff_T05H4.8 AFF_T05H4.9 Aff_T05H4.9 AFF_T08B6.1 Aff_T08B6.1 AFF_T21C12.4 Aff_T21C12.4 AFF_Y13C8_223.B Aff_Y13C8_223.B AFF_Y13C8_223.D Aff_Y13C8_223.D AFF_Y17G9B.D Aff_Y17G9B.D AFF_Y32F6A.1 Aff_Y32F6A.1 AFF_Y38A10A.C Aff_Y38A10A.C AFF_Y39B6.R Aff_Y39B6.R AFF_Y39G10A_246.I Aff_Y39G10A_246.I AFF_Y40B10A_112.B Aff_Y40B10A_112.B AFF_Y40H7.D Aff_Y40H7.D AFF_Y41E3.5 Aff_Y41E3.5 AFF_Y47D3A.O Aff_Y47D3A.O AFF_Y4C6A.D Aff_Y4C6A.D AFF_Y53G8B_93.E Aff_Y53G8B_93.E AFF_Y54C5B.1 Aff_Y54C5B.1 AFF_Y63D3A.1 Aff_Y63D3A.1 AFF_ZK105_3.G Aff_ZK105_3.G B0001.6 Aff_B0001.6 B0001.6; B0001.6.1; B0001.6.2; B0001.6.3; 4M927; CE31863; WBGene00007091; WP:CE31863 B0025.1 Aff_B0025.1 let-512; vps-34; B0025.1; B0025.1b.1; B0025.1b.2; B0025.1c.1; B0025.1c.2; B0025.1d.1; B0025.1d.2; 1G609; CE24759; CE24760; CE37691; CE37738; CE37739; NM_059340; WBGene00006932; WP:CE24759; WP:CE24760; WP:CE37691; WP:CE37738; WP:CE37739 The vps-34 gene encodes an ortholog of the phosphoinositide 3-kinase VPS34 in S. cerevisiae, a protein that regulates multiple steps in endocytosis, and that is required for growth at normal rates during development. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0035.14 Aff_B0035.14 dnj-1; B0035.14; 4M69; CE05169; NM_069721; WBGene00001019; WP:CE05169 This gene encodes a protein containing a DnaJ ('J') domain. DNAJ protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0035.7 Aff_F54E12.5 his-47; B0035.7; 4M88; NM_069730; WBGene00001921; his 12 his-47 encodes an H2A histone; by homology, HIS-47 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-47 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV. histone H2A Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated B0035.9 Aff_F54E12.3 his-46; B0035.9; 4M90; NM_069732; WBGene00001920 his-46 encodes an H4 histone. histone H4 ViswanathanM et al 2005 S2 sir-2.1 regulated B0041.2 Aff_B0041.2 B0041.2; B0041.2a.1; B0041.2a.2; 1F227; CE27563; CE29526; CE33546; WBGene00015007; WP:CE27563; WP:CE29526; WP:CE33546 ViswanathanM et al 2005 S2 sir-2.1 regulated B0041.4 Aff_B0041.4 rpl-4; B0041.4; B0041.4.1; B0041.4.2; B0041.4.3; 1F214; CE07669; NM_059015; WBGene00004415; WP:CE07669 rpl-4 encodes a large ribosomal subunit L4 protein. ribosomal protein L1 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0041.7 Aff_B0041.7 slr-8; xnp-1; B0041.7; 1F234; CE17314; NM_059022; WBGene00006961; WP:CE17314 xnp-1 encodes an ATP-dependent DNA helicase of the SNF2 family that is orthologous to human XNP/ATR-X, which is associated with a number of X-linked mental retardation syndromes; in C. elegans, xnp-1 activity is required at high temperatures for embryogenesis, somatic gonad development, fertility, and vulval morphogenesis; in addition, animals doubly mutant for xnp-1 and lin-35/Rb, hpl-2/HP1, or nucleosome remodelling and histone deacetylase (NuRD) complex members such as lin-53 and let-418, display larval arrest with growth cessation but continued cell proliferation; xnp-1 is also required, with lin-35/Rb and hpl-2/HP1, for proper regulation of transgene expression; xnp-1 mRNA, detectable in embryos and the germline by in situ hybridization, is expressed at highest levels in embryos with decreasing levels seen in successive larval stages; xnp-1 transcriptional reporter fusions exhibit strong expression beginning at mid-embryogenesis but fading by embryonic morphogenesis; at hatching, expression is observed in all dividing cells including the P lineage, and at later larval stages expression is observed in the vulval precursor cells. helicase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph B0207.12 Aff_B0207.12 avr-14; gbr-2; B0207.12; 1G544; CE26421; CE30227; CE32092; WBGene00000232; WP:CE26421; WP:CE30227; WP:CE32092 avr-14 encodes an alpha-type subunit of a glutamate-gated chloride channel homologous to human GLRA2, which when mutated leads to hyperekplexia (OMIM:149400); AVR-14 affects sensitivity to the antiparisitic drug, ivermectin, in parallel with avr-15 and glc-1 and in a genetic pathway with unc-9; it functions in the extrapharyngeal nervous system, and is expressed in a subset of neurons in the ring ganglia, ventral cord, and some mechanosensory neurons. B0238.1 Aff_B0238.1 B0238.1; 5F718; CE07691; WBGene00015067; WP:CE07691 carboxylesterase Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T1 B0250.1 Aff_B0250.1 rpl-2; B0250.1; B0250.1.1; B0250.1.2; 5U949; CE18478; NM_075539; WBGene00004413; WP:CE18478 rpl-2 encodes a large ribosomal subunit L8 protein. Ribosomal Proteins L2 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0252.2 Aff_B0252.2 asm-1; B0252.2; 2H201; CE30230; NM_063014; WBGene00000211; WP:CE30230 Spingomyelin phosphodiesterase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0280.3 Aff_B0280.3 B0280.3; B0280.3.1; B0280.3.2; 3I213; CE00733; WBGene00015101; WP:CE00733 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0284.3 Aff_B0284.3 B0284.3; 3F468; CE28525; WBGene00007133; WP:CE28525 B0285.7 Aff_B0285.7 B0285.7; 3F453; CE00646; WBGene00007139; WP:CE00646 Aminopeptidase Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0304.1 Aff_B0304.1 hlh-1; B0304.1; 2E811; CE02423; CE30067; CE31766; MyoD1; WBGene00001948; WP:CE02423; WP:CE30067; WP:CE31766 hlh-1 encodes a basic helix-loop-helix (bHLH) transcription factor that is the sole C. elegans member of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryonic development for the proper differentiation and function of body wall muscle cells, indicating that unlike its vertebrate counterparts, hlh-1 is not absolutely required for body wall muscle specification; however, ectopic expression of hlh-1 in the embryo is sufficient to convert nearly all embryonic cell types to a muscle-like fate; in regulating body wall muscle cell development in some cell lineages, hlh-1 likely lies downstream of the PAL-1 homeodomain protein that is required for specification of the C and D founder cell fates; HLH-1 is expressed in nuclei and first appears in body wall muscle precursors beginning at the ~80-cell stage of embryogenesis; expression then continues in these cells and their differentiated descendants throughout embryonic, larval, and adult stages of development. helix-loop-helix transcription factor Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Roy et al 2002 S2 positivecontrol L1 muscle, ViswanathanM et al 2005 S2 sir-2.1 regulated B0310.4 Aff_B0310.4 B0310.4; CE03877; WBGene00015140; WP:CE03877; XB132 repetitive proline-rich cell wall protein B0336.10 Aff_B0336.10 rpl-23; B0336.10; B0336.10.1; B0336.10.2; 3G794; CE00778; NM_065830; WBGene00004435; WP:CE00778 rpl-23 encodes a large ribosomal subunit L23 protein. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0511.1 Aff_B0511.1 fkb-7; B0511.1; 1L245; CE26851; NM_060391; WBGene00001432; WP:CE26851 fkb-7 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506-binding proteins; by homology, FKB-7 could function in a number of different processes including protein folding, signal transduction, and regulation of muscle contraction; however, as loss of fkb-7 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of FKB-7 in C. elegans development and/or behavior is not yet known. Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated B0511.6 Aff_B0511.6 B0511.6; B0511.6.1; B0511.6.2; 1L203; CE26853; WBGene00015232; WP:CE26853 helicase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0563.8 Aff_B0563.8 B0563.8; CE39467; WBGene00015265; WP:CE39467; XJ788 C01G10.8 Aff_C01G10.8 C01G10.8; C01G10.8.1; C01G10.8.2; 5P564; CE07817; WBGene00007235; WP:CE07817 Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C01G5.6 Aff_C01G5.6 C01G5.6; 4H289; CE23513; WBGene00015308; WP:CE23513 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched C01G6.3 Aff_C01G6.3 C01G6.3; 2J561; CE37474; WBGene00007225; WP:CE37474 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C01H6.7 Aff_C01H6.7 tag-298; C01H6.7; 1H803; CE05190; WBGene00007256; WP:CE05190 Bromodomain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C02B8.2 Aff_C02B8.2 C02B8.2; CE03891; WBGene00015321; WP:CE03891; XI761 C02F5.1 Aff_C02F5.1 knl-1; C02F5.1; 3J343; CE02450; NM_066410; WBGene00002231; WP:CE02450 knl-1 encodes a novel acidic protein with a coiled-coil region at its C-terminus; KNL-1 is an essential kinetochore component that is required for proper spindle elongation and chromosome separation, and in the kinetochore assembly pathway, plays a key role in linking the initiation of kinetochore formation with the construction of a functional microtubule-binding interface; in the assembly pathway, KNL-1 functions downstream of the DNA-proximal kinetochore components CeCENP-A/HCP-3 and CeCENP-B/HCP-4 and upstream of the outer kinetochore components HIM-10/Nuf2p, NDC-80/HEC1, CeBUB-1, HCP-1, and CeCLASP2/CLS-2; in expression studies in the one-cell embryo, KNL-1 localizes to kinetochores throughout mitosis. Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C02F5.6 Aff_C02F5.6 C02F5.6; CE00042; CE30417; NM_171212; NM_171213; WBGene00015349; WP:CE00042; WP:CE30417 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C03B1.12 Aff_C03B1.12 lmp-1; C03B1.12; C03B1.12.1; C03B1.12.2; CE03912; NM_076671; WBGene00003053; WP:CE03912; XG996 lmp-1 encodes a protein with similarity to vertebrate lysosome-associated membrane proteins CD68, and appears to be the only protein in C. elegans that has a GYXX (phi) vertebrate lysosomal targeting sequence at its carboxy terminus; localized to the periphery of a large population of membrane bound organelles (granules) seen throughout the early embryos and restricted to the cells of the intestine during later stages. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C03D6.3 Aff_C03D6.3 cel-1; C03D6.3; 1K243; CE05197; CE32300; NM_060168; WBGene00000466; WP:CE05197; WP:CE32300 cel-1 encodes a mRNA capping enzyme, with a N-terminal region with RNA triphosphatase activity and a C-terminal region containing motifs found in yeast and vaccinia virus capping enzyme guanylytransferases; cel-1 is required for embryonic viability, body morphology, and vulval development. Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset C03H5.7 Aff_C03H5.7 C03H5.7; 2A673; CE07900; WBGene00015409; WP:CE07900 ViswanathanM et al 2005 S2 daf-16 Resveratrol C04A2.1 Aff_C04A2.1 C04A2.1; 2H139; CE36523; WBGene00015410; WP:CE36523 Shen et al 2005 T1 hif-1 depend hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C04E7.2 Aff_C04E7.2 C04E7.2; CE28816; WBGene00015429; WP:CE28816; XA975 C04F12.9 Aff_C04F12.9 C04F12.9; 1K286; CE19682; WBGene00007303; WP:CE19682 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Golden et al 2004, N2 vs daf-2 different genes at , Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C04F6.3 Aff_C04F6.3 cht-1; C04F6.3; C04F6.3.1; C04F6.3.2; CE03923; CHT1; NM_076187; WBGene00000503; WP:CE03923; XE16 cht-1 encodes a chitinase orthologous to human chitinase-1 (OMIM:600031, mutations are associated with chitotriosidase deficiency); CHT-1 is predicted to function as an extracellular O-glycosyl hydrolase that hydrolyzes the glycosidic bond between two or more carbohydrates; in C. elegans, CHT-1 may play a role in embryogenesis, and may also be required for cuticle degradation during molting and degradation of chitin-containing pathogens as part of a host defense mechanism. glycosyl hydrolase (family 18) Bishop et al 2004 T1 Upregulated in vhl-1 vs WT, Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C05B5.4 Aff_C05B5.4 C05B5.4; 3L81; CE00880; WBGene00007321; WP:CE00880 ViswanathanM et al 2005 S2 sir-2.1 regulated C05C10.2 Aff_C05C10.2 C05C10.2; C05C10.2b.1; C05C10.2b.2; 2K219; CE01466; CE27795; WBGene00007329; WP:CE01466; WP:CE27795 NAM7 protein ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C05C8.5 Aff_C05C8.5 C05C8.5; 5H714; CE07923; WBGene00015462; WP:CE07923 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C05E4.1 Aff_C05E4.1 pes-21; C05E4.1; 5B243; CE07935; NM_070917; WBGene00005643; WP:CE07935 srp-2 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily that is orthologous to human NEUROSERPIN (OMIM:602445, mutated in familial encephalopathy with neuroserpin inclusion bodies); SRP-2 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases, and in vitro, recombinant SRP-2 is able to inhibit granzyme B activity; however, as loss of srp-2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-2 in C. elegans development and/or behavior is not yet known; srp-2 expression is detected in hypodermal cells, particularly in the lateral seam cells. serine protease inhibitor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S6 removed genes of contamination C05G5.3 Aff_C05G5.3 C05G5.3; CE30853; WBGene00007349; WP:CE30853; XP370 C05G5.4 Aff_C05G5.4 C05G5.4; CE05227; WBGene00007350; WP:CE05227; XP373 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. succinyl-CoA synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C06A6.2 Aff_C06A6.1 C06A6.2; 4I617; CE31152; CE31153; WBGene00015507; WP:CE31152; WP:CE31153 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C06A8.3 Aff_C06A8.3 C06A8.3; 2I81; CE02454; WBGene00015514; WP:CE02454 17k antigen (O. volvulus) ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Zhang et al 2002, T1 mec-3 dependent genes C06A8.5 Aff_C06A8.5 C06A8.5; 2I73; CE02456; WBGene00015515; WP:CE02456 Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated C06E1.1 Aff_C06E1.1 C06E1.1; 3J695; CE00054; WBGene00015518; WP:CE00054 ViswanathanM et al 2005 S2 sir-2.1 regulated C06E7.4 Aff_C06E7.4 C06E7.4; 4G616; CE29026; WBGene00015541; WP:CE29026 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol C06G4.2 Aff_C06G4.2 clp-1; C06G4.2; C06G4.2a.1; C06G4.2a.2; C06G4.2b.1; C06G4.2b.2; C06G4.2b.3; 3J75; CE00517; CE30486; CE37743; CE37744; NM_066339; NM_066340; NM_171201; NM_171886; WBGene00000542; WP:CE00517; WP:CE30486; WP:CE37743; WP:CE37744 clp-1 encodes a calpain homolog that has significant identity to mammalian calpains over its whole length and that contains motifs typical of calpains, including a thiol (cysteine) protease active site and a Ca[2+]-binding domain; CLP-1 is required, in parallel with TRA-3 but in series with ASP-3 and ASP-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C07A12.7 Aff_C07A12.7 C07A12.7; C07A12.7a.1; C07A12.7a.2; C07A12.7c.1; C07A12.7c.2; CE25764; CE27055; CE33557; WBGene00015561; WP:CE25764; WP:CE27055; WP:CE33557; XF138 C07A9.2 Aff_C07A9.2 C07A9.2; C07A9.2.1; C07A9.2.2; 3J784; 3K784; CE00499; WBGene00007400; WP:CE00499 G10 protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories C07A9.6 Aff_C07A9.6 ugt-60; C07A9.6; C07A9.6.1; C07A9.6.2; 3K766; CE33970; WBGene00007402; WP:CE33970 UDP-glucuronosyltransferase C07D10.5 Aff_C07D10.5 C07D10.5; 2H673; CE36628; WBGene00015569; WP:CE36628 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C08A9.7 Aff_C08A9.7 sdz-2; C08A9.7; CE06789; WBGene00015587; WP:CE06789; XR714 ViswanathanM et al 2005 S2 daf-16 Resveratrol C08F1.3 Aff_C08F1.3 fbxb-13; C08F1.3; 2C79; CE08018; WBGene00015607; WP:CE08018 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C08F1.6 Aff_C08F1.6 C08F1.6; 2C78; CE08021; WBGene00015610; WP:CE08021 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol C08F8.4 Aff_C08F8.4 C08F8.4; 4L922; CE05251; WBGene00007446; WP:CE05251 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm C08F8.5 Aff_C08F8.5 fbxb-9; C08F8.5; 4L924; CE05252; WBGene00007447; WP:CE05252 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol C09B8.5 Aff_C09B8.5 C09B8.5; CE02465; WBGene00015624; WP:CE02465; XG640 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated C09D4.5 Aff_C09D4.5 rpl-19; C09D4.5; C09D4.5.1; C09D4.5.2; C09D4.5.3; 1G54; CE08034; NM_059207; WBGene00004431; WP:CE08034 rpl-19 encodes a large ribosomal subunit L19 protein. 60S ribosomal protein L19 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C09H6.3 Aff_C09H6.3 mau-2; C09H6.3; 1I705; CE15611; NM_059827; WBGene00003136; WBGene00007498; WP:CE15611 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C10F3.4 Aff_C10F3.4 C10F3.4; 5G449; CE30723; CE37609; WBGene00015678; WP:CE30723; WP:CE37609 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C10G11.7 Aff_C10G11.7 C10G11.7; C10G11.7.1; C10G11.7.2; C10G11.7.3; 1G865; CE08086; WBGene00015687; WP:CE08086 Reinke et al 2004, list of genes in cluster order C10G8.6 Aff_C10G8.6 ceh-34; C10G8.6; 5F794; CE20496; NM_072018; WBGene00000455; WP:CE20496 ceh-34 encodes a homeodomain protein, homologous to human SIX2 (OMIM:604994), that is expressed very weakly in the pharynxes of late embryos and early larvae; it has no known function. homeobox protein C10H11.3 Aff_C10H11.3 ugt-25; C10H11.3; 1F303; CE08092; WBGene00015692; WP:CE08092 7TM chemoreceptor, ugt family Kwon et al 2004 T1 late-induction Ethanol-response, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, fem3 enriched genes C13C12.2 Aff_C13C12.2 C13C12.2; 5N4; CE08133; WBGene00007552; WP:CE08133 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 C14A4.1 Aff_C14A4.1 tag-242; C14A4.1; C14A4.1.1; C14A4.1.2; CE02138; WBGene00007555; WP:CE02138 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C15C8.1 Aff_C15C8.1 C15C8.1; 5N215; CE05285; WBGene00007604; WP:CE05285 ViswanathanM et al 2005 S2 daf-16 Resveratrol C15H9.7 Aff_C15H9.7 C15H9.7; CE06835; WBGene00015802; WP:CE06835; XG726 kynureninase McCarroll et al 2004 SFig5 conserved w/ yeast, Murphy et al 2003 Fig2 Class2 shorten lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C16C4.6 Aff_C16C4.6 fbxb-98; C16C4.6; 2C131; CE08202; WBGene00015830; WP:CE08202 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 daf-16 Resveratrol C17B7.3 Aff_C17B7.3 C17B7.3; 5D823; CE16851; WBGene00015877; WP:CE16851 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C17G1.3 Aff_C17G1.3 ugt-23; C17G1.3; CE08282; WBGene00007650; WP:CE08282; XK542 UDP-glucosyltransferase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C18A11.5 Aff_C18A11.5 xol-1; C18A11.5; CE24807; CE35708; CE35709; WBGene00006962; WP:CE24807; WP:CE35708; WP:CE35709; XI661 ViswanathanM et al 2005 S2 sir-2.1 regulated C18D1.1 Aff_C18D1.1 die-1; C18D1.1; C18D1.1.1; C18D1.1.2; 2K352; CE01501; NM_063774; WBGene00000995; WP:CE01501 die-1 encodes a C2H2 zinc finger protein containing four fingers, homologous to CG18265-PA in Drosophila; DIE-1 is autonomously required in the posterior dorsal hypodermis for intercalation, for morphogenesis in other embryonic tissues, and for normal postembryonic growth and vulval development. Zinc finger, C2H2 type (3 domains) Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol C18D11.4 Aff_C18D11.4 rsp-8; C18D11.4; C18D11.4.1; C18D11.4.2; 3M919; CE18515; NM_067132; WBGene00004705; WP:CE18515 RNA recognition motif. (aka RRM, RBD, or RNP domain) ViswanathanM et al 2005 S2 sir-2.1 regulated C18G1.2 Aff_C18G1.2 C18G1.2; 5F251; CE17418; WBGene00015981; WP:CE17418 GATA transcription factor Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C23G10.8 Aff_C23G10.8 C23G10.8; C23G10.9; 3H292; CE25784; WBGene00016015; WP:CE25784 S. pombe adenylyl cyclase-associated protein (weak) Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen C24B5.4 Aff_C24B5.4 C24B5.4; 5J674; CE37611; WBGene00016046; WP:CE37611 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C24H11.2 Aff_C24H11.1 C24H11.2; 3M880; CE18525; WBGene00007700; WP:CE18525 Protein phosphatase-1 (PP1) Reinke et al 2004, male sperm, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, mixed sperm soma, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, GO categories C24H12.4 Aff_C24H12.4 C24H12.4; 2A705; CE27728; CE29675; WBGene00016073; WP:CE27728; WP:CE29675 helicase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen C25A1.4 Aff_C25A1.4 C25A1.4; C25A1.4.1; C25A1.4.2; 1K746; CE08369; WBGene00007706; WP:CE08369 RNA binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C25D7.3 Aff_C25D7.3 dpy-29; sdc-3; C25D7.3; 5P520; CE08389; NM_074302; WBGene00004747; WP:CE08389 sdc-3 encodes a protein that contains two mutationally separable domains: a zinc finger motif required for dosage compensation and a myosin- like putative ATP- binding region required for her-1 regulation of sex determination; SDC-3 activates dosage compensation by directing the dosage compensation protein complex to the hermaphrodite X chromosomes, and is functionally redundant with SDC-2 with respect to dosage compensation; SDC-1, SDC-2, and SDC-3 proteins form a complex. Zinc finger, C2H2 type Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C25F6.3 Aff_C25F6.3 C25F6.3; CE38489; WBGene00016103; WP:CE38489; XG89 The C25F6.3 gene encodes an ortholog of the human gene DIHYDROPYRIMIDINE DEHYDROGENASE (DPYD), which when mutated leads to thymine-uraciluria (OMIM:274270). McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C26B9.1 Aff_C26B9.1 C26B9.1; CE30880; CE34262; NM_076507; WBGene00016131; WP:CE30880; WP:CE34262 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C26E6.8 Aff_C26E6.8 ula-1; C26E6.8; C26E6.8.1; C26E6.8.2; 3G8; CE29678; NM_065636; WBGene00006735; WP:CE29678 The ula-1 gene encodes a component of the enzyme that activates NED-8, which in turn is a ubiquitin-like protein whose conjugating enzyme is UBC-12. Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C27A12.6 Aff_C27A12.6 C27A12.6; 1G630; CE08415; WBGene00016156; WP:CE08415 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C27C7.7 Aff_C27C7.7 C27C7.7; 1M11; CE18537; WBGene00007769; WP:CE18537 C28A5.4 Aff_C28A5.4 ceh-43; C28A5.4; 3F536; CE05325; NM_065503; WBGene00000463; WP:CE05325 A homeobox protein of the Distal-less (Dll) class that is required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability; it is predominantly expressed in the head hypdodermis, neuronal support cells and CAN neurons. homeobox protein (distal-less subfamily) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Portman et al 2004 T1 25 candidate ray genes, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C28C12.7 Aff_C28C12.7 spp-10; C28C12.7; C28C12.7a.1; C28C12.7a.2; 4J243; CE29486; CE31323; NM_171399; NM_171400; WBGene00004995; WP:CE29486; WP:CE31323 spp-10 encodes two protein isoforms that are orthologous to the human gene PROSAPOSIN (PSAP; OMIM:176801, mutated in Gaucher disease and metachromatic leukodystrophy); SPP-10A and -10B are predicted to have 3 and 4 embedded saposin sequences, that are likely to be split into individual saposin peptides by proteolysis; in mammals, saposins activate the enzymes sphingomyelinphosphodiesterase and beta-glucosylceramidase; spp-10 has no obvious function in mass RNAi assays. 7TM chemoreceptor, spp family Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C28G1.4 Aff_C28G1.4 C28G1.4; CE04121; WBGene00016189; WP:CE04121; XJ468 zinc finger C28H8.1 Aff_C28H8.1 C28H8.1; 3H17; CE01820; WBGene00016192; WP:CE01820 C28H8.1 is orthologous to the human gene BCL7A (OMIM:601406), which when mutated leads to high-grade B-cell non-Hodgkin lymphoma. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, IVb male soma enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C29A12.3 Aff_C29A12.3 lig-1; C29A12.3; 5L295; CE37480; CE37481; NM_171537; NM_171538; WBGene00002985; WP:CE37480; WP:CE37481 lig-1 is orthologous to the human gene LIM HOMEOBOX PROTEIN 3 ISOFORM B (LIG1; OMIM:600577), which when mutated leads to disease. Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C29F3.1 Aff_C29F3.1 ech-1; C29F3.1; 5P838; CE08435; NM_074409; WBGene00001150; WP:CE08435 long-chain enoyl-CoA hydratase C29F4.1 Aff_C29F4.1 col-125; C29F4.1; C29F4.1.1; C29F4.1.2; 4L991; CE03038; NM_069706; WBGene00000699; WP:CE03038 collagen Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C29F7.2 Aff_C29F7.2 C29F7.2; CE35414; WBGene00007811; WP:CE35414; XO35 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes C29F7.6 Aff_C29F7.6 C29F7.6; CE08447; WBGene00007813; WP:CE08447; XO59 Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C30G4.3 Aff_C30G4.3 gcy-11; C30G4.3; CE39901; NM_078354; WBGene00001537; WP:CE39901; XR660 guanylate cyclase receptor Baugh et al 2005, PAL-1 target genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C30G4.6 Aff_C30G4.6 C30G4.6; CE39902; WBGene00016271; WP:CE39902; XR688 ViswanathanM et al 2005 S2 daf-16 Resveratrol C31B8.8 Aff_C31B8.8 C31B8.8; 5D384; CE26674; WBGene00016283; WP:CE26674 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C31E10.7 Aff_C31E10.7 C31E10.7; C31E10.7.1; C31E10.7.2; CE37487; WBGene00007848; WP:CE37487; XO621 C31E10.7 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:10230) (CYB5; OMIM:250790), which when mutated leads to disease. cytochrome b5 Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C31G12.1 Aff_C31G12.1 C31G12.1; 5S657; CE15660; WBGene00007850; WP:CE15660 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C31H5.4 Aff_C31H5.4 C31H5.4; C31H5.4.1; C31H5.4.2; 1J618; CE17484; NM_060029; WBGene00007855; WP:CE17484 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C32B5.14 Aff_C32B5.14 C32B5.14; 2B254; CE08522; WBGene00016307; WP:CE08522 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C32B5.16 Aff_C32B5.16 sdz-4; C32B5.16; 2B251; CE08524; WBGene00016309; WP:CE08524 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C32B5.5 Aff_C32B5.5 C32B5.5; 2B261; CE34725; WBGene00016298; WP:CE34725 C32E8.7 Aff_C32E8.7 ric-19; C32E8.7; 1E346; CE39089; NM_058815; WBGene00004368; WP:CE39089 The ric-19 gene encodes an evolutionarily conserved cytosolic protein involved in neuroendocrine secretion via association with secretory vesicles. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C32F10.2 Aff_C32F10.2 lin-35; C32F10.2; 1G391; CE24823; NM_059285; WBGene00003020; WP:CE24823 lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, lin-35 activity is required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C33A12.2 Aff_C33A12.2 nlp-35; C33A12.2; 4K284; CE05348; WBGene00007881; WP:CE05348 C33C12.5 Aff_C33C12.5 fbxb-38; C33C12.5; 2C458; CE08553; WBGene00016337; WP:CE08553 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes C33F10.4 Aff_C33F10.3 C33F10.4; 2F87; CE02530; CE02531; CE27103; WBGene00016353; WP:CE02530; WP:CE02531; WP:CE27103 McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C33G3.3 Aff_C33G3.3 C33G3.3; CE08559; WBGene00007903; WP:CE08559; XO686 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C33G3.4 Aff_C33G3.4 C33G3.4; CE08560; WBGene00007904; WP:CE08560; XO693 C33G3.4 is orthologous to the human gene BETA-MANNOSIDASE (MANBA; OMIM:248510), which when mutated leads to disease. beta-mannosidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C34B2.3 Aff_C34B2.3 C34B2.3; 1L251; CE34266; WBGene00016388; WP:CE34266 protein kinase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, GO categories, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 sir-2.1 regulated C34C6.6 Aff_C34C6.6 PEX-5; prx-5; C34C6.6; 2I995; CE03054; CE36377; WBGene00004194; WP:CE03054; WP:CE36377 prx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B C34D10.1 Aff_C34D10.1 C34D10.1; CE02532; WBGene00016406; WP:CE02532; XI649 ViswanathanM et al 2005 S2 sir-2.1 regulated C34E10.7 Aff_C34E10.7 cnd-1; hlh-5; C34E10.7; 3G328; CE01187; NM_065714; WBGene00000561; WP:CE01187 cnd-1 is orthologous to the human gene NEUROGENIC DIFFERENTIATION 1 (NEUROD1; OMIM:601724), which when mutated leads to disease. C34F11.4 Aff_C34F11.4 msp-50; C34F11.4; 2F491; NM_062571; WBGene00003443 msp-50 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C34F6.6 Aff_C34F6.6 C34F6.6; CE15675; WBGene00007940; WP:CE15675; XL826 ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT C35C5.1 Aff_C35C5.1 sdc-2; C35C5.1; CE18542; NM_077523; WBGene00004746; WP:CE18542; XM151 The sdc-2 gene encodes a protein that represses transcription of X chromosomes to achieve dosage compensation, and that also represses the male sex-determination gene her-1 to elicit hermaphrodite differentiation. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C35D10.13 Aff_C35D10.13 C35D10.13; 3F966; CE01194; WBGene00016449; WP:CE01194 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C36B1.5 Aff_C36B1.5 C36B1.5; C36B1.5.1; C36B1.5.2; 1J310; CE05372; WBGene00007972; WP:CE05372 U4/U6 small nuclear ribonucleoprotein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C37A2.8 Aff_C37A2.8 C37A2.8; 1H376; CE08617; CE29218; WBGene00016494; WP:CE08617; WP:CE29218 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C37C3.8 Aff_C37C3.8 tag-253; C37C3.8; C37C3.8a.1; C37C3.8a.2; C37C3.8a.3; C37C3.8a.4; 5I326; CE06933; CE30736; WBGene00016500; WP:CE06933; WP:CE30736 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C37E2.1 Aff_C37E2.1 C37E2.1; C37E2.1.1; C37E2.1.2; C37E2.1.3; CE08620; WBGene00007993; WP:CE08620; XO790 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. isocitrate dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C38C10.4 Aff_C38C10.4 ags-3.3; gpr-2; C38C10.4; 3K482; CE00107; NM_066665; WBGene00001689; WP:CE00107 gpr-2 encodes a protein containing a GPR (G Protein Regulator)/GoLoco motif characteristic of guanine nucleotide exchange factors specific for G-alpha GTPases; GPR-2 appears to function redundantly during early embryogenesis and germ-line development to regulate chromosome and spindle movements during cell division; GPR-2 likely acts as a positive regulator of G protein signaling and specifically, may regulate GOA-1 signaling in the embryo; GPR-2 forms a protein complex with the nearly identical GPR-1 and with LIN-5, a coiled-coil protein that is required for proper localization of GPR-2 to the cell cortex and spindle asters of the early embryo; in addition, proper GPR-2/GPR-1/LIN-5 localization between the P2 and EMS blastomeres at the four-cell stage, which may contribute to spindle positioning in EMS, requires the MES-1/SRC-1 tyrosine kinase signaling pathway; GPR-2 is believed to act downstream of, or in parallel to, PAR-3, a PDZ domain-containing protein, in mitotic spindle positioning in the early embryo. Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C38C6.4 Aff_C38C6.4 sre-13; C38C6.4; 2O918; CE38042; NM_064641; WBGene00007997; WP:CE38042 7TM receptor, sre family C39D10.8 Aff_C39D10.4 C39D10.8; CE29713; CE29714; CE30501; WBGene00016535; WP:CE29713; WP:CE29714; WP:CE30501; XI498 Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C39E9.11 Aff_C39E9.11 C39E9.11; 4N856; CE20559; WBGene00008034; WP:CE20559 C39E9.11 is orthologous to the human gene PAPILLARY RENAL CELL CARCINOMA (TRANSLOCATION-ASSOCIATED) (PRCC; OMIM:179755), which when mutated leads to disease. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C40A11.4 Aff_C40A11.4 C40A11.4; 2C429; CE36797; WBGene00016547; WP:CE36797 C40A11.7 Aff_C40A11.7 C40A11.7; 2C438; CE19370; WBGene00016550; WP:CE19370 C43D7.2 Aff_C43D7.2 fbxb-65; C43D7.2; 5T805; CE18547; WBGene00008066; WP:CE18547 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C43D7.8 Aff_Y116F11.I C43D7.8; 5T784; CE18552; WBGene00008070; WP:CE18552 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 daf-16 Resveratrol C43E11.10 Aff_C43E11.10 cdc-6; C43E11.10; 1E838; CE08688; NM_058942; WBGene00000382; WP:CE08688 cdc-6 encodes a homolog of an origin complex component (CDC6) which in yeast controls the start of DNA replication, and also has a distant paralog (Y39A1A.12) within the C. elegans genome; CDC-6 is superficially dispensable for embryonic viability, perhaps because of redundancy with Y39A1A.12. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C43H6.4 Aff_C43H6.4 C43H6.4; CE33917; WBGene00016617; WP:CE33917; XD25 Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C43H6.7 Aff_C43H6.7 C43H6.7; CE06958; WBGene00016620; WP:CE06958; XD16 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C44B9.3 Aff_C44B9.3 C44B9.3; 3L966; CE05405; WBGene00008080; WP:CE05405 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C44C1.1 Aff_C44C1.1 C44C1.1; CE35432; WBGene00016641; WP:CE35432; XB601 Romagnolo et al 2002 Fig3b Unkown, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C44C10.1 Aff_C44C10.1 col-180; C44C10.1; CE05408; NM_077559; WBGene00000753; WP:CE05408; XM332 collagen Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C44C8.6 Aff_C44C8.6 mak-2; C44C8.6; C44C8.6b.1; C44C8.6b.2; 4B641; CE17545; CE33566; NM_067604; NM_067605; WBGene00007007; WP:CE17545; WP:CE33566 protein kinase ViswanathanM et al 2005 S2 sir-2.1 regulated C44E4.6 Aff_C44E4.6 acbp-1; C44E4.6; C44E4.6.1; C44E4.6.2; C44E4.6.3; C44E4.6.4; 1F204; CE08720; NM_059011; WBGene00016655; WP:CE08720 acyl-CoA-binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C44F1.3 Aff_C44F1.3 lec-4; C44F1.3; 3E862; CE02163; NM_065362; WBGene00002267; WP:CE02163 lec-4 encodes a predicted galectin that exhibits sugar binding properties in vitro. galactoside binding lectin Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C44H4.5 Aff_C44H4.5 tap-1; C44H4.5; CE08726; NM_078027; WBGene00006524; WP:CE08726; XP209 Protein phosphatase 2C Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C45G3.1 Aff_C45G3.1 tag-255; C45G3.1; 1J798; CE15710; WBGene00008107; WP:CE15710 The C45G3.1 gene encodes a protein, with one N-terminal calponin-like actin-binding domain and two IQ calmodulin-binding domains, that is likely to be required for spindle structure and function, and (indirectly) for neural function, based on its orthology to Drosophila ABNORMAL SPINDLE and on its joint sterile and uncoordinated RNAi phenotypes; C45G3.1 is also orthologous to human ASPM (OMIM:605481), which when mutated leads to primary microcephaly; C45G3.1 is required for embryonic and larval viability, germline maintenance, vulval morphogenesis, meiosis, and locomotion. Actinin-type actin-binding domain containing proteins McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen C45G3.5 Aff_C45G3.3 C45G3.5; C45G3.5.1; C45G3.5.2; CE37812; WBGene00044008; WP:CE37812 C45G7.4 Aff_C45G7.4 C45G7.4; 4D199; CE17550; WBGene00016671; WP:CE17550 zinc finger protein ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT C46H11.2 Aff_C46H11.2 C46H11.2; 1F619; CE08784; WBGene00016728; WP:CE08784 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 C47D12.4 Aff_C47D12.4 C47D12.4; 2L969; CE20568; WBGene00008138; WP:CE20568 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol C47E12.8 Aff_C47E12.8 CeCRMP/DHP-2; dhp-2; C47E12.8; 4K745; CE05452; NM_069396; WBGene00000964; WP:CE05452 The dhp-2 gene encodes an ortholog of the human gene DIHYDROPYRIMIDINASE (DPYS), which when mutated leads to dihydropyrimidinuria (OMIM:222748). Ulip like protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C47E8.4 Aff_C47E8.4 C47E8.4; 5P164; CE35838; WBGene00008143; WP:CE35838 Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C48E7.1 Aff_C48E7.1 C48E7.1; 1G839; CE08816; WBGene00016749; WP:CE08816 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C50F2.1 Aff_C50F2.1 C50F2.1; 1E461; CE36635; WBGene00016835; WP:CE36635 ViswanathanM et al 2005 S2 sir-2.1 regulated C50F2.4 Aff_C50F2.4 C50F2.4; 1E456; CE08910; WBGene00016838; WP:CE08910 C50F2.7 Aff_C50F2.7 C50F2.7; 1E468; CE08913; WBGene00016840; WP:CE08913 ViswanathanM et al 2005 S2 sir-2.1 regulated C50F4.6 Aff_C50F4.6 his-36; C50F4.6; 5K25; CE05471; NM_073064; WBGene00001910; WP:CE05471 his-36 encodes an UNSPECIFIED histone. C50F4.7 Aff_C50F4.7 his-37; C50F4.7; 5K27; NM_073065; WBGene00001911 his-37 encodes an H4 histone. histone H4 ViswanathanM et al 2005 S2 sir-2.1 regulated C51E3.2 Aff_C51E3.2 srsx-27; C51E3.2; 5K627; CE33986; NM_073208; WBGene00008248; WP:CE33986 opoid receptor C52A10.3 Aff_C52A10.3 C52A10.3; 5F716; CE17584; WBGene00016864; WP:CE17584 ViswanathanM et al 2005 S2 sir-2.1 regulated C52B9.7 Aff_C52B9.7 paf-2; C52B9.7; CE30264; CE30265; NM_171668; WBGene00003907; WP:CE30264; WP:CE30265; XE910 paf-2 encodes a homolog of vertebrate Type II Platelet-activating factor-acetylhydrolase (PAF-AH) that is 70% identical to PAF-2 that is required for embryogenesis and affects organization of the hypodermis. ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C52E2.1 Aff_C52E2.I fbxb-95; C52E2.1; C52E2.I; 2C127; CE25826; WBGene00016880; WP:CE25826 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C52E2.6 Aff_C52E2.B fbxb-97; C52E2.6; C52E2.B; 2C122; CE36808; WBGene00016885; WP:CE36808 C53A5.3 Aff_C53A5.3 gon-10; hda-1; C53A5.3; C53A5.3.1; C53A5.3.2; 5P7; CE08952; NM_074198; WBGene00001834; WP:CE08952 The hda-1 gene encodes a histone deacetylase 1, similar to histone deacetylases RPD3 from yeast and fly; maternal and zygotic expression of hda-1 is required for embryonic viability, and zygotic expression of hda-1 is also required for gonadogenesis and vulval development. Yeast RPD3 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C53D5.5 Aff_C53D5_1638.C C53D5.5; C53D5.5.1; C53D5.5.2; C53D5.5.3; CE23612; NM_058313; WBGene00016906; WP:CE23612 The C53D5.5 gene encodes an ortholog of the human gene GAMMA-GLUTAMYLTRANSFERASE 1 (GGT1), which when mutated leads to glutathionuria (OMIM:231950). gamma-glutamyltranspeptidase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C53H9.2 Aff_C53H9.2 C53H9.2; C53H9.2b.1; C53H9.2b.2; C53H9.2b.3; C53H9.2b.4; C53H9.2c.1; C53H9.2c.2; C53H9.2c.3; C53H9.2c.4; 1C307; CE08963; CE33575; CE39907; WBGene00016907; WP:CE08963; WP:CE33575; WP:CE39907 C53H9.2 encodes at least three protein isoforms orthologous to the GTP-binding proteins human GNL1 (HSR1; OMIM:143024) and murine MMR1, as well as LSG1 in S. cerevisiae and many other eukaryotic and bacterial proteins; one alternative transcription unit of the C53H9.2 locus, C53H9.2a, has a natural nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that C53H9.2 is a natural substrate for SMG-mediated nonsense suppresssion; C53H9.2 is required in mass RNAi assays for embryonic viability, normally rapid growth, and early embryonic nuclear positioning; since several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-8, rpl-10a, rpl-12) have protein products that are involved in translation, C53H9.2's protein products may function in translation as well, an inference supported by the observed role of LSG1 in cytoplasmic 60S ribosomal subunit biogenesis. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C54G7.2 Aff_C54G7.2 C54G7.2; C54G7.2.1; C54G7.2.2; CE04270; WBGene00016934; WP:CE04270; XG140 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C55A6.9 Aff_C55A6.9 C55A6.9; 5M3; CE20614; WBGene00008338; WP:CE20614 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated D1007.6 Aff_D1007.6 rps-10; D1007.6; D1007.6.1; D1007.6.2; 1F152; CE09041; NM_058997; WBGene00004479; WP:CE09041 rps-10 encodes a small ribosomal subunit S10 protein. 40S ribosomal protein S10 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol D1009.1 Aff_D1009.1 D1009.1; CE04285; CE27891; WBGene00017012; WP:CE04285; WP:CE27891; XJ557 fatty acid transporter protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 D1022.4 Aff_D1022.4 D1022.4; 2H746; CE02578; WBGene00017023; WP:CE02578 ViswanathanM et al 2005 S2 sir-2.1 regulated D1044.1 Aff_D1044.1 D1044.1; 3G635; CE39140; WBGene00017027; WP:CE39140 ViswanathanM et al 2005 S2 sir-2.1 regulated D1046.1 Aff_D1046.1 D1046.1; D1046.1.1; D1046.1.2; D1046.1.3; D1046.1.4; 4J693; CE03094; WBGene00008362; WP:CE03094 glycine-rich RNA-binding protein Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen D1053.1 Aff_D1053.1 gst-42; D1053.1; CE03099; NM_077561; WBGene00001790; WP:CE03099; XM346 gst-42 is orthologous to the human gene GLUTATHIONE TRANSFERASE ZETA-1 (also known as MALEYLACETOACETATE ISOMERASE; GSTZ1; OMIM:603758), which when mutated is thought to lead to a variety of type I tyrosinemia. glutathione S-transferase Kwon et al 2004 T1 late-repression Ethanol-respon, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b Oxidation, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 D1081.2 Aff_D1081.2 unc-120; D1081.2; 1J37; CE05534; NM_059895; WBGene00006844; WP:CE05534 unc-120 encodes a member of the MADS-box family of transcription factors that contains human and Drosophila serum response factor (SRF) and Saccharomyces cerevisiae MCM1 and ARG80; UNC-120 is required for locomotion and muscle development and for formation of the normal number of muscle A and I bands; UNC-120 is also required for maintaining wild-type expression levels of the muscle components actin and myosin; UNC-120 is first expressed in the early embryo in body wall muscle precursors and later is expressed in both body wall and vulval muscles. MADS domain Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order D1081.8 Aff_D1081.8 phi-7; D1081.8; D1081.8.1; D1081.8.2; 1J71; CE05540; WBGene00008386; WP:CE05540 MYB transforming protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E D2045.7 Aff_D2045.7 D2045.7; 3L565; CE37761; WBGene00008424; WP:CE37761 serine/threonine kinase Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, fem3 enriched genes, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit D2089.1 Aff_D2089.1 rsp-7; D2089.1; D2089.1b.1; D2089.1b.2; D2089.1b.3; 2K951; CE03111; CE30507; NM_171033; NM_171034; WBGene00004704; WP:CE03111; WP:CE30507 RNA binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes D2092.2 Aff_D2092.2 D2092.2; D2092.2.1; D2092.2.2; 1H202; CE09101; WBGene00017064; WP:CE09101 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated DY3.2 Aff_DY3.2 lmn-1; DY3.2; DY3.2.1; DY3.2.2; 1J341; CE15746; Lam1; NM_059970; WBGene00003052; WP:CE15746 The lmn-1 gene encodes a nuclear lamin; LMN-1 protein is essential for the nuclear envelope localization of emerin (EMR-1) protein during during early development. Intermediate filament proteins (2 domains) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated E01A2.2 Aff_E01A2.H E01A2.2; E01A2.2b.1; E01A2.2b.2; 1E703; CE20643; CE33369; WBGene00017085; WP:CE20643; WP:CE33369 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen E01A2.4 Aff_E01A2.D, Aff_E01A2.E, Aff_E01A2.F E01A2.4; 1E698; CE24871; WBGene00017086; WP:CE24871 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated E02D9.1 Aff_C37A2.1 C37A2.1; E02D9.1; E02D9.1b.1; E02D9.1b.2; 1H379; CE08610; CE27902; CE31335; CE31336; WBGene00017098; WP:CE08610; WP:CE27902; WP:CE31335; WP:CE31336 protein kinase Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 E02H1.4 Aff_E02H1.4 pme-2; E02H1.4; 2J883; CE01539; WBGene00004050; WP:CE01539 ADP-Ribosyltransferase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated E04F6.2 Aff_E04F6.2 E04F6.2; 2H491; CE01214; WBGene00017122; WP:CE01214 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated EEED8.4 Aff_EEED8.4 EEED8.4; 2F699; CE39716; WBGene00017135; WP:CE39716 Probable RNA binding protein F01D4.5 Aff_F01D4.5 F01D4.5; 4L248; CE29035; CE29036; WBGene00008488; WP:CE29035; WP:CE29036 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F01F1.6 Aff_F01F1.6 alh-9; F01F1.6; F01F1.6.1; F01F1.6.2; F01F1.6.3; 3G947; CE39486; NM_065862; WBGene00000115; WP:CE39486 Aldehyde dehydrogenase Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F01G10.7 Aff_F01G10.7 F01G10.7; 4L4; CE09169; WBGene00008510; WP:CE09169 triacylglycerol lipase Jones et al 2001 Non dauer genes P<0.05 F02E9.10 Aff_F02E9.6 F02E9.10; F02E9.10a.1; F02E9.10a.2; F02E9.10b.1; F02E9.10b.2; 1J4; CE27119; CE38314; WBGene00008533; WP:CE27119; WP:CE38314 F07A11.5 Aff_F07A11.5 F07A11.5; 2L903; CE03147; WBGene00008548; WP:CE03147 ribokinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F07C3.9 Aff_F07C3.9 F07C3.9; 5J734; CE07030; WBGene00017197; WP:CE07030 Jones et al 2001 Dauer specific genes P<0.05, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F07E5.2 Aff_F07E5.2 fbxb-35; F07E5.2; 2C343; CE09215; WBGene00017208; WP:CE09215 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated F07E5.6 Aff_F07E5.6 fbxb-36; F07E5.6; 2C348; CE09218; WBGene00017211; WP:CE09218 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes F08B4.5 Aff_F08B4.5 F08B4.5; 4J448; CE29749; WBGene00017237; WP:CE29749 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F08B4.7 Aff_F08B4.7 F08B4.7; F08B4.7.1; F08B4.7.2; 4J452; CE09232; WBGene00017238; WP:CE09232 U1 small nuclear ribonucleoprotein C McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08B6.2 Aff_F08B6.E gpc-2; F08B6.2; F08B6.2.1; F08B6.2.2; F08B6.2.3; 1H335; CE20656; NM_059534; WBGene00001682; WP:CE20656 gpc-2 encodes one of two C. elegans heterotrimeric G protein gamma subunits; gpc-2 is required, along with its partner GPB-1, a G protein beta subunit, for proper mitotic spindle positioning and orientation during early embryonic cell divisions; to date, GPC-2 expression has been reported in electrically excitable cells (all neurons and muscles). ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08C6.2 Aff_F08C6.2 F08C6.2; CCT; CE30937; CE39144; WBGene00017241; WP:CE30937; WP:CE39144; XI199 F08C6.2 encodes a lipid-activated CTP:phosphocholine cytidylyltransferase (CCT), with CCT activity in vitro; recombinant F08C6.2 enzyme is most activated by a 1:1 mixture of phosphatidylcholine:oleate vesicles; a inhibitory 21-residue segment (residues 246-266) is critical for specific activation of F08C6.2 by lipids, since deletion or mutation of this segment causes F08C6.2 to be constitutively active without its normal lipid substrate; F08C6.2 has no obvious function in mass RNAi assays. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F08D12.11 Aff_F08D12.11 fbxb-111; F08D12.11; 2D64; CE09244; WBGene00017254; WP:CE09244 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F08D12.8 Aff_F08D12.8 fbxb-105; F08D12.8; 2D58; CE09241; WBGene00017251; WP:CE09241 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08D12.9 Aff_F08D12.9 fbxb-109; sdz-10; F08D12.9; 2D60; CE09242; WBGene00017252; WP:CE09242 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08F1.5 Aff_F08F1.5 ced-8; F08F1.5; CE34294; NM_077026; WBGene00000422; WP:CE34294; XJ34 The ced-8 gene encodes a homolog of the human putative membrane transporter XK; ced-8 is required for apoptosis to occur with normal speed during embryonic development. Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E F08G12.2 Aff_F08G12.2 F08G12.2; CE18578; WBGene00008586; WP:CE18578; XL916 WD domain, G-beta repeat (6 domains) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F08G2.3 Aff_F08G2.3 his-42; F08G2.3; 2O120; NM_064498; WBGene00001916 his-42 encodes an H3 histone. Core histones H2A, H2B, H3 and H4 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F08G2.7 Aff_F08G2.7 F08G2.7; 2O128; CE19779; WBGene00008578; WP:CE19779 F08G2.8 Aff_F08G2.8 F08G2.8; 2O145; CE19780; WBGene00008579; WP:CE19780 F09C3.4 Aff_F09C3.4 fbxa-103; F09C3.4; 1O876; CE09279; WBGene00008612; WP:CE09279 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F09E5.10 Aff_F09E5.10 F09E5.10; 2F638; CE02605; WBGene00017288; WP:CE02605 ViswanathanM et al 2005 S2 sir-2.1 regulated F09F7.8 Aff_F09F7.8 nspb-12; F09F7.8; 3G656; CE38594; WBGene00017305; WP:CE38594 nspb family ViswanathanM et al 2005 S2 sir-2.1 regulated F09G2.4 Aff_F09G2.4 F09G2.4; 5H661; CE09299; WBGene00017313; WP:CE09299 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol F10C5.1 Aff_Y55B1A_115.C apc-8; mat-3; pod-4; vex-2; F10C5.1; F10C5.1.1; F10C5.1.2; 3B99; CE26888; NM_064802; WBGene00003134; WBGene00006909; WP:CE26888 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F10D2.6 Aff_F10D2.6 ugt-37; F10D2.6; 5H616; CE30747; WBGene00017332; WP:CE30747 7TM chemoreceptor, ugt family Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F10E9.8 Aff_F10E9.8 dcd-1; sas-4; F10E9.8; 3J404; CE29756; NM_066427; WBGene00004726; WP:CE29756 sas-4 encodes a predicted coiled-coil protein and centriole component recruited to the centrosome once per cell cycle at the time of organelle duplication and is required for centriole duplication and spindle assembly, levels dictate centrosome size, and also affects germ cell proliferation and locomotion; colocalizes with gamma-tubulin to centrosomes both in sperm and in the syncitial part of the gonad. Lund et al 2002 Fig1 aging-regulated genes, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F11H8.1 Aff_F11H8.1 cyk-5; rfl-1; uba-3; F11H8.1; 3I113; CE34538; NM_066133; WBGene00004341; WP:CE34538 rfl-1 (also known as cyk-5) encodes an ortholog of UBA3, a Nedd8 activating enzyme for ubiquitin-like proteins, which is required for proper cytokinesis and spindle orientation; NED-8 is presumably activated by an ULA-1/RFL-1 heterodimer. ubiquitin-activating enzyme McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 Resveratrol regulate WT F13B10.2 Aff_F13B10.2 rpl-3; F13B10.2; F13B10.2a.1; F13B10.2a.2; F13B10.2d.1; F13B10.2d.2; 3E959; CE05598; CE36996; CE36997; NM_065382; WBGene00004414; WP:CE05598; WP:CE36996; WP:CE36997 rpl-3 encodes a large ribosomal subunit L3 protein required in mass RNAi assays for embryonic and larval viability, fertility, and general health; the rpl-3 transcription unit has a nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-3 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-7, rpl-10, rpl-12) have protein products that are involved in translation. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F13B12.1 Aff_F13B12.1 F13B12.1; F13B12.1.1; F13B12.1.2; 4L188; CE05599; WBGene00008729; WP:CE05599 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F13B9.1 Aff_F13B9.1 F13B9.1; CE30949; CE35469; CE37100; WBGene00017419; WP:CE30949; WP:CE35469; WP:CE37100; XI911 F13B9.1 encodes two proteins by alternative splicing which contain both an immunoglobulin/MHC-like domain and a glutamine/asparagine-rich domain. ViswanathanM et al 2005 S2 sir-2.1 regulated F13C5.2 Aff_F13C5.2 F13C5.2; CE19384; WBGene00017423; WP:CE19384; XB213 bromodomain-containing protein McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol F13E6.1 Aff_F13E6.1 F13E6.1; CE31474; WBGene00008745; WP:CE31474; XL294 D52 protein Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F13G3.10 Aff_F13G3.10 F13G3.10; CE17660; NM_059669; WBGene00008768; WP:CE17660 ViswanathanM et al 2005 S2 sir-2.1 regulated F13H8.7 Aff_F13H8.7 F13H8.7; F13H8.7.1; F13H8.7.2; F13H8.7.3; 2G578; CE02641; WBGene00017440; WP:CE02641 beta-ureidopropionase (rat) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F14B6.3 Aff_F14B6.3 F14B6.3; 1M823; CE17665; WBGene00008784; WP:CE17665 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol F14B6.6 Aff_F14B6.6 F14B6.6; 1M825; CE25856; WBGene00008787; WP:CE25856 Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F14E5.4 Aff_F14E5.4 F14E5.4; 2I720; CE03207; WBGene00008802; WP:CE03207 acid phosphatase Reinke et al 2004, male sperm, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, mixed sperm soma, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, GO categories F14H3.3 Aff_F14H3.3 F14H3.3; 5Q532; CE23651; WBGene00008822; WP:CE23651 Golden et al 2004, daf-2 differentially expressed , Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F15A4.2 Aff_F15A4.2 F15A4.2; 2M755; CE15839; WBGene00008838; WP:CE15839 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F15B10.2 Aff_F15B10.2 drh-1; F15B10.2; F15B10.2.1; F15B10.2.2; 4H372; CE16988; NM_068617; WBGene00001090; WP:CE16988 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Reinke et al 2004, wt herm vs wt male enriched gen F15C11.2 Aff_F15C11.2 F15C11.2; 1H603; CE09413; CE31479; CE31480; WBGene00008852; WP:CE09413; WP:CE31479; WP:CE31480 Ubiquitin family McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F16H11.2 Aff_F16H11.2 F16H11.2; CE04397; WBGene00017531; WP:CE04397; XF281 ViswanathanM et al 2005 S2 sir-2.1 regulated F17A9.2 Aff_F17A9.2 F17A9.2; 5G593; CE19798; WBGene00017534; WP:CE19798 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F17A9.5 Aff_F17A9.5 F17A9.5; 5G592; CE09449; WBGene00017537; WP:CE09449 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination F17A9.6 Aff_F17A9.6 ceh-49; F17A9.6; 5G600; CE27970; WBGene00017538; WP:CE27970 F17A9.6 encodes a divergent ONECUT class CUT homeobox protein with a single N-terminal cut domain; F17A9.6 has an atypical tyrosine residue at position 48 of its homeodomain rather than a phenylalanine or tryptophan residue; the cut domain may be a compact DNA-binding domain composed of alpha helices; phylogenetically, F17A9.6 is (somewhat distantly) affiliated with C17H12.9, Drosophila ONECUT, and mammalian HNF6 proteins; F17A9.6 has no obvious function in mass RNAi assays. homeobox protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F17C11.2 Aff_F17C11.2 F17C11.2; F17C11.2.1; F17C11.2.2; 5L427; CE05649; WBGene00008914; WP:CE05649 Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F17C11.4 Aff_F17C11.4 F17C11.4; 5L433; CE05651; WBGene00008915; WP:CE05651 Jones et al 2001 Dauer specific genes P<0.05, Jones et al 2001 T3 20 most abundant Dauer, Lund et al 2002 Fig4 Mount 15, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F17E9.12 Aff_F17E9.12 his-31; F17E9.12; 4J96; NM_069005; WBGene00001905 his-31 encodes an H4 histone; his-31 is contained within the histone gene cluster HIS5. ViswanathanM et al 2005 S2 sir-2.1 regulated F17E9.13 Aff_F35H10.1 his-33; F17E9.13; 4J100; NM_069007; WBGene00001907 his-33 encodes an H2A histone; by homology, HIS-33 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-33 is a replication-dependent histone locus that resides in the HIS5 cluster on chromosome IV. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F17H10.3 Aff_F17H10.3 F17H10.3; CE31483; WBGene00008927; WP:CE31483; XN732 PhoX homologous domain, present in p47phox and p40phox. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F19B10.1 Aff_F19B10.1 F19B10.1; 2D975; CE09468; WBGene00017583; WP:CE09468 ViswanathanM et al 2005 S2 sir-2.1 regulated F19C7.3 Aff_F19C7.3 F19C7.3; 4F361; CE04417; WBGene00017593; WP:CE04417 F19F10.5 Aff_F19F10.5 F19F10.5; 5I36; CE09485; WBGene00017601; WP:CE09485 DNA-binding protein ViswanathanM et al 2005 S2 sir-2.1 regulated F20B6.7 Aff_F20B6.7 F20B6.7; CE04429; WBGene00017631; WP:CE04429; XE826 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F21D9.1 Aff_F21D9.1 F21D9.1; 5T745; CE18627; WBGene00009015; WP:CE18627 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F21D9.3 Aff_F21D9.3 F21D9.3; 5T724; CE18629; WBGene00009017; WP:CE18629 Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, shared sperm F21D9.5 Aff_F21D9.5 F21D9.5; 5T721; CE18631; WBGene00009019; WP:CE18631 F22B3.2 Aff_F22B3.2 his-63; F22B3.2; 4M170; NM_069752; WBGene00001937 his-63 encodes an H3 histone; by homology, HIS-63 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-63 is a replication-dependent histone locus. histone H3 Jones et al 2001 Non dauer genes P<0.05 F22B5.2 Aff_F22B5.2 eif-3.G; F22B5.2; 2I733; CE02197; NM_063377; WBGene00001230; WP:CE02197 eif-3.G encodes a homolog of eukaryotic translation initiation factor 3, subunit 4 that affects embryonic viability, fertility, and growth. RNA binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F22B7.9 Aff_F22B7.9 F22B7.9; 3J742; CE29771; WBGene00017698; WP:CE29771 Jones et al 2001 Dauer specific genes P<0.05, Kwon et al 2004 T1 late-repression Ethanol-respon, Lund et al 2002 Fig4 Mount 15, Romagnolo et al 2002 Fig3b Unkown, Romagnolo et al 2002 Fig5 genes in let-60 timecour, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F22B8.6 Aff_F22B8.6 F22B8.6; F22B8.6.1; F22B8.6.2; 5Q581; CE15884; WBGene00009048; WP:CE15884 cystathione gamma-lyase like Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F22B8.7 Aff_F22B8.7 F22B8.7; 5Q577; CE37509; WBGene00009049; WP:CE37509 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F22E5.1 Aff_F22E5.1 F22E5.1; 2C965; CE09553; WBGene00017703; WP:CE09553 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F22E5.17 Aff_F34D6.1 F22E5.17; 2C969; CE27992; WBGene00017712; WP:CE27992 F22F1.1 Aff_F22F1.1 hil-3; F22F1.1; H1.3; CE04443; NM_076974; WBGene00001854; WP:CE04443; XI779 histone h1 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes F22H10.4 Aff_F22H10.4 F22H10.4; CE09573; WBGene00017728; WP:CE09573; XR296 F23A7.1 Aff_F23A7.1 F23A7.1; CE09576; WBGene00009067; WP:CE09576; XQ831 F23A7.4 Aff_F23A7.4 F23A7.4; CE09578; WBGene00009069; WP:CE09578; XQ825 glutamate receptor epsilon subunit like ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F23D12.5 Aff_F23D12.5 F23D12.5; CE15893; WBGene00009089; WP:CE15893; XP71 F23H11.5 Aff_F23H11.5 F23H11.5; F23H11.5.1; F23H11.5.2; F23H11.5.3; 3B528; CE09613; WBGene00000263; WP:CE09613 The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway. ViswanathanM et al 2005 S2 sir-2.1 regulated F25B4.6 Aff_F25B4.6 phi-50; F25B4.6; 5G164; CE09624; WBGene00017769; WP:CE09624 F25B4.6 is orthologous to the human gene 3-HYDROXY-3-METHYLGLUTARYL COA SYNTHASE (HMGCS2; OMIM:600234), which when mutated leads to disease. hydroxymethlglutaryl-CoA synthase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F25B5.7 Aff_F25B5.7 F25B5.7; 3H44; CE01924; CE29284; CE29285; CE32391; WBGene00017778; WP:CE01924; WP:CE29284; WP:CE29285; WP:CE32391 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F25C8.2 Aff_F25C8.2 amx-3; F25C8.2; 5V368; CE39726; NM_075633; WBGene00000139; WP:CE39726 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F25E2.5 Aff_F25E2.5 daf-3; F25E2.5; CE26364; CE28002; CE30963; NM_075760; WBGene00000899; WP:CE26364; WP:CE28002; WP:CE30963; XB438 daf-3 encodes a Smad protein; DAF-3 functions as a transcriptional regulator that is required for formation of the alternative dauer larval stage; DAF-3 activity is antagonized by signaling through the DAF-7/TGF-beta pathway which promotes reproductive growth; in yeast two-hybrid studies, DAF-3 interacts with SMA-3, another Smad protein that does not appear to have a role in dauer formation; a DAF-3::GFP fusion protein is expressed in many tissues that undergo remodeling during dauer development; DAF-3 localizes predominantly to the cytoplasm, but is also found associated with chromosomes in mitotic cells. Jones et al 2001 T2 lifespan and Dauer, ViswanathanM et al 2005 S2 daf-16 Resveratrol F25G6.3 Aff_F25G6.3 acr-16; F25G6.3; 5J43; CE09639; CE32878; Ce21; NM_072806; WBGene00000055; WP:CE09639; WP:CE32878 acr-16 encodes an alpha-7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily orthologous to human nicotinic cholinergic receptor alpha 7 (CHRNA7; OMIM:118511; possibly associated with schizophrenia and juvenile myoclonic epilepsy); ACR-16 functions as a ligand-gated ion channel that probably regulates fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-16 is active as a homomeric receptor and responds robustly to acetylcholine when expressed in Xenopus oocytes. Lund et al 2002 Fig3B neuro-specific genes, Romagnolo et al 2002 Fig3b signaling, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F25H2.10 Aff_F25H2.10 rpa-0; F25H2.10; F25H2.10.1; F25H2.10.2; 1L145; CE09655; NM_060365; WBGene00004408; WP:CE09655 rpa-0 encodes an acidic ribosomal subunit protein P0. deoxyribonuclease McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F26A3.8 Aff_F26A3.3 rrf-1; F26A3.8; 1I220; CE27141; NM_059730; WBGene00004508; WP:CE27141 rrf-1 encodes an RNA-directed RNA polymerase (RdRP) homolog required for somatic (but not germline) RNAi; RRF-1 is also required for 'transitive interference'. F26D10.11 Aff_F26D10.11 F26D10.11; 4S219; CE19811; WBGene00009155; WP:CE19811 F26D10.11 encodes an ortholog of murine TMHS (mutated in hurry-scurry/hscy mice), a predicted tetraspan membrane protein required for stereociliary function and a possible ortholog of human DFNB53; the cysteine mutated in hscy mice is conserved in F26D10.11. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F26D10.12 Aff_F26D10.12 F26D10.12; 4S221; CE19812; WBGene00009156; WP:CE19812 Lectin C-type domain Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E F26F12.7 Aff_F26F12.7 chd-4; evl-11; let-418; F26F12.7; 5G311; CE17716; NM_072122; WBGene00002637; WP:CE17716 The let-418 gene encodes a homolog of Mi-2/CHD3, a component of the nucleosome remodeling and histone deacetylase (NURD) complex; LET-418 is similar to DNA helicases, homologous to human AIRE (OMIM:607358, mutated in autoimmune polyendocrinopathy syndrome), and paralogous to CHD-3; with MEP-1, LET-418 is required to repress germline-specific genes in somatic cells, and also negatively regulates RAS-dependent postembryonic vulval development (via the synMuvB pathway); LET-418 and CHD-3 are redundantly required for specification of secondary cell fates in vulval development; LET-418 is expressed in all interphase nuclei throughout development; LET-418 is bound by MEP-1, and also interacts with HDA-1 and PIE-1; these interactions probably reflect repression of LET-418 by PIE-1 in the germline. DNA helicase Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F27C1.4 Aff_F27C1.4 F27C1.4; 1F991; CE09717; WBGene00017854; WP:CE09717 ViswanathanM et al 2005 S2 sir-2.1 regulated F27D9.6 Aff_F27D9.6 dhs-29; F27D9.6; CE28011; NM_076893; WBGene00000992; WP:CE28011; XI282 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 F27E11.3 Aff_F27E11.3 cfz-2; F27E11.3; 5D920; CE39149; CE39150; CFZ2; NM_071563; NM_071564; WBGene00000478; WP:CE39149; WP:CE39150 cfz-2 encodes a member of the Frizzled family of membrane receptors. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol F28C6.7 Aff_F28C6.7 rpl-26; F28C6.7; F28C6.7a.1; F28C6.7a.2; 2I893; CE03278; CE20731; CE32883; NM_063422; NM_063423; NM_182165; WBGene00004440; WP:CE03278; WP:CE20731; WP:CE32883 rpl-26 encodes a large ribosomal subunit L26 protein; by homology, RPL-26 is predicted to function in protein biosynthesis; in C. elegans, RPL-26 activity is required for embryonic and germline development and normal rates of postembryonic growth. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F28F8.3 Aff_F28F8.3 lsm-5; F28F8.3; F28F8.3.1; F28F8.3.2; 5Q49; CE09757; NM_074469; WBGene00003079; WP:CE09757 small nuclear ribonucleoprotein E (SNRNP-E) like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F29A7.1 Aff_F29A7.1 fbxb-106; F29A7.1; 2D53; CE09772; WBGene00017911; WP:CE09772 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes F29A7.2 Aff_F29A7.2 fbxb-107; F29A7.2; 2D51; CE36834; WBGene00017912; WP:CE36834 F29D11.2 Aff_F29D11.2 F29D11.2; 1I212; CE09790; WBGene00009254; WP:CE09790 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F31D5.6 Aff_F31D5.6 F31D5.6; 2E501; CE19829; WBGene00017949; WP:CE19829 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated F31E3.1 Aff_F31E3.1 ceh-20; F31E3.1; 3I71; CE01241; WBGene00000443; WP:CE01241 A co-factor homeodomain protein and homolog of Drosophila Extradenticle (Exd) that together with ceh-40 affects embryogenesis, loss of both functions affect embryonic viability; it is required as a cofactor for LIN-39- and MAB-5- dependent postembryonic mesoderm patterning; it genetically interacts with unc-62. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F32A11.6 Aff_F32A11.6 moe-3; F32A11.6; 2N452; CE18657; NM_064394; WBGene00003388; WP:CE18657 Zinc finger C-x8-C-x5-C-x3-H type (and similar). ViswanathanM et al 2005 S2 sir-2.1 regulated F32B6.9 Aff_F32B6.9 F32B6.9; 4K667; CE09864; WBGene00009323; WP:CE09864 Putative membrane protein F32D1.10 Aff_F32D1.10 mcm-7; F32D1.10; F32D1.10.1; F32D1.10.2; 5E827; CE09874; NM_071798; WBGene00003159; WP:CE09874 cell division control protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F32D1.5 Aff_F32D1.5 F32D1.5; F32D1.5.1; F32D1.5.2; 5E848; CE09869; WBGene00017984; WP:CE09869 GMP reductase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F32E10.6 Aff_F32E10.6 F32E10.6; F32E10.6.1; F32E10.6.2; 4I344; CE04479; WBGene00017993; WP:CE04479 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F33C8.1 Aff_F33C8.1 tag-53; F33C8.1; CE32400; CE32401; WBGene00006432; WP:CE32400; WP:CE32401; XP337 tag-53 encodes a protein with high similarity to human Attractin, and affects fertility and locomotion. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F33E2.5 Aff_F33E2.5 F33E2.5; F33E2.5.1; F33E2.5.2; 1N184; CE09906; NM_060790; WBGene00009361; WP:CE09906 Jones et al 2001 Non dauer genes P<0.05 F34H10.3 Aff_F34H10.3 F34H10.3; F34H10.3.1; F34H10.3.2; CE01573; WBGene00009380; WP:CE01573; XK252 protein S10 ViswanathanM et al 2005 S2 sir-2.1 regulated F35C11.6 Aff_F35C11.6 F35C11.6; 2I548; CE02212; WBGene00009405; WP:CE02212 F35E2.2 Aff_F35E2.2 F35E2.2; 1M326; CE17772; WBGene00009410; WP:CE17772 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated F35E2.8 Aff_F35E2.8 F35E2.8; 1M309; CE17777; WBGene00009415; WP:CE17777 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated F35H10.11 Aff_F17E9.9 his-29; F35H10.11; 4J92; NM_069002; WBGene00001903 his-29 encodes an H2B histone. histone H2B F35H8.7 Aff_F35H8.7 wee-1.1; F35H8.7; 2J872; CE09940; NM_063657; WBGene00006938; WP:CE09940 serine/threonine kinase ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F36A2.3 Aff_F36A2.3 F36A2.3; 1J377; CE15964; WBGene00009453; WP:CE15964 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F36H5.4 Aff_F36H5.4 F36H5.4; 2C53; CE09961; WBGene00018103; WP:CE09961 F36H5.8 Aff_F36H5.8 F36H5.8; 2C38; CE09965; WBGene00018106; WP:CE09965 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Murphy et al 2003 Fig2 Class2 shorten lifespan F37C12.1 Aff_F37C12.1 F37C12.1; 3I277; CE00742; WBGene00018149; WP:CE00742 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F37C12.4 Aff_F37C12.4 rpl-36; F37C12.4; F37C12.4.1; F37C12.4.2; F37C12.4.3; 3I271; CE30781; NM_066172; WBGene00004450; WP:CE30781 rpl-36 encodes a large ribosomal subunit L36 protein; by homology, RPL-36 is predicted to function in protein biosynthesis; in C. elegans, RPL-36 activity is required for embryonic and germline development and normal postembryonic growth rates. Ribosomal protein YL39 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F37C4.6 Aff_F37C4.6 F37C4.6; F37C4.6.1; F37C4.6.2; 4E640; CE17049; WBGene00018146; WP:CE17049 phytoene desaturase Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F37D6.4 Aff_F37D6.4 F37D6.4; 1L65; CE05821; WBGene00009510; WP:CE05821 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma F37H8.5 Aff_F37H8.5 F37H8.5; CE15997; WBGene00009514; WP:CE15997 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F38B2.4 Aff_F38B2.4 F38B2.4; F38B2.4.1; F38B2.4.2; CE02218; WBGene00009531; WP:CE02218; XL906 F38B2.4 is orthologous to the human gene ADENYLATE KINASE 1 (AK1; OMIM:103000), which when mutated leads to hemolytic anemia. adenylate kinase Link et al 2003 T2 Abeta repressed, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b Metabolism, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F38E11.3 Aff_F38E11.3 cpin-1; F38E11.3; 4K215; CE26624; NM_069268; WBGene00000775; WP:CE26624 cpi-1 is orthologous to a mammalian protein variously identified as guanine aminohydrolase (or guanine deaminase, or guanase), cypin, or p51-nedasin. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F38H4.2 Aff_F38H4.2 fbxb-3; F38H4.2; 4M605; CE10060; WBGene00009546; WP:CE10060 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated F39F10.4 Aff_F39F10.4 F39F10.4; CE07206; WBGene00018204; WP:CE07206; XR516 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma F39G3.2 Aff_F39G3.2 F39G3.2; 5F217; CE35304; WBGene00018207; WP:CE35304 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F39H2.5 Aff_F39H2.1 F39H2.5; F39H2.5.1; F39H2.5.2; 1J239; CE30531; WBGene00009564; WP:CE30531 Jones et al 2001 T3 20 most abundant Dauer, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes F40F4.1 Aff_F40F4.1 fbxb-71; F40F4.1; CE04531; WBGene00018236; WP:CE04531; XD883 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Murphy et al 2003 Fig2 Class2 shorten lifespan, Romagnolo et al 2002 Fig3b Unkown, Romagnolo et al 2002 Fig5 genes in let-60 timecour, ViswanathanM et al 2005 S2 sir-2.1 regulated F40F9.5 Aff_F40F9.5 F40F9.5; 5K202; CE37834; WBGene00009582; WP:CE37834 translocase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F40F9.6 Aff_F40F9.6 F40F9.6; F40F9.6b.1; F40F9.6b.2; 5K206; CE05855; CE23714; WBGene00009583; WP:CE05855; WP:CE23714 glycosyl hydrolase F40G9.5 Aff_F40G9.5 F40G9.5; 3A799; CE19852; WBGene00018241; WP:CE19852 Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F40G9.6 Aff_F40G9.6 F40G9.6; 3A795; CE19853; WBGene00018242; WP:CE19853 Reinke et al 2004, list of genes in cluster order F40H6.4 Aff_F40H6.4 CE-TBX-11; tbx-11; F40H6.4; 3H134; CE01281; NM_065916; WBGene00006547; WP:CE01281 tbx-11 encodes a T-box transcription factor that is orthologous to members of the Tbx2 subfamily of T-box transcription factors; by homology, TBX-11 is predicted to function in transcriptional regulation during cellular differentiation, potentially as both an activator and a repressor; however, as loss of tbx-11 function via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of tbx-11 in C. elegans development and/or behavior is not yet known. Reinke et al 2004, list of genes in cluster order F41C6.1 Aff_F41C6.1 unc-106; unc-6; F41C6.1; F41C6.1.1; F41C6.1.2; CE04538; NM_076764; WBGene00006746; WP:CE04538; XH515 unc-6 encodes a netrin orthologous to the human and mouse netrin-1 precursor proteins; UNC-6 functions as a guidance molecule that regulates the migrations of pioneer axons and mesodermal cells, such as the gonadal distal tip cell, along the dorsoventral axis; a secreted molecule, UNC-6 is expressed during embryogenesis by epidermoblasts and neurons; UNC-6 is involved in both attractive and repulsive interactions that are mediated by the UNC-40 and UNC-5 netrin receptors, respectively. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F41E6.13 Aff_F41E6.13 tag-283; F41E6.13; F41E6.13b.1; F41E6.13b.2; 5J110; CE10268; CE30784; WBGene00018294; WP:CE10268; WP:CE30784 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F42A6.7 Aff_F42A6.7 hrp-1; rbp-1; F42A6.7; F42A6.7a.1; F42A6.7a.2; F42A6.7a.3; F42A6.7b.1; F42A6.7b.2; F42A6.7b.3; F42A6.7b.4; 4E102; CE17059; CE29317; CE31510; CE39251; NM_067925; WBGene00001999; WP:CE17059; WP:CE29317; WP:CE31510; WP:CE39251 The hrp-1 gene encodes a homolog of the human DRPLA gene (OMIM:125370), which when mutated leads to dentatorubral-pallidoluysian atrophy or to Haw River syndrome (OMIM:140340). McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F42E11.1 Aff_F42E11.1 pgp-4; F42E11.1; F42E11.1.1; F42E11.1.2; CE03308; NM_077501; WBGene00003998; WP:CE03308; XL981 pgp-4 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-4 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-4 activity via deletion mutations or RNAi results in no obvious defects, the precise role of PGP-4 in C. elegans development and/or behavior is not yet known; pgp-4 promoter-gfp fusion proteins are expressed in the larval excretory cell. p-glycoprotein F42G2.6 Aff_F42G2.6 F42G2.6; 2C718; CE32659; WBGene00018355; WP:CE32659 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol F42G9.2 Aff_F42G9.2 cyn-6; cyp-6; F42G9.2; 3B391; CE01301; NM_064856; WBGene00000882; WP:CE01301 cyp-6 encodes a cyclophilin most similar to human secreted cyclophilin type B isoforms that is functional when expressed in E. coli; it is expressed in the intestine. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F43C11.6 Aff_F43C11_37.D F43C11.6; 2C633; CE20780; WBGene00018383; WP:CE20780 ViswanathanM et al 2005 S2 sir-2.1 regulated F43G9.10 Aff_F43G9.10 F43G9.10; 1J216; CE10372; WBGene00009671; WP:CE10372 MICROFIBRILLAR-ASSOCIATED PROTEIN 1 (ASSOCIATED MICROFIBRIL PROTEIN) (AMF) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Cell Structure, ViswanathanM et al 2005 S2 sir-2.1 regulated F43H9.1 Aff_F43H9.1 ech-3; F43H9.1; 5I503; CE07245; NM_072665; WBGene00001152; WP:CE07245 enoyl-coA hydratase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F44A2.7 Aff_F44A2.7 F44A2.7; 5J799; CE35308; WBGene00018406; WP:CE35308 F44B9.7 Aff_F44B9.7 pqn-38; F44B9.7; 3J116; CE29043; NM_066348; WBGene00004125; WP:CE29043 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F44C4.5 Aff_F44C4.5 ppt-1; F44C4.5; 5H104; CE07253; NM_072283; WBGene00004092; WP:CE07253 ppt-1 is orthologous to the human gene PALMITOYL-PROTEIN THIOESTERASE 1 (PPT1; OMIM:600722), which when mutated leads to infantile neuronal ceroid lipofuscinosis 1 (OMIM:256730) and juvenile neuronal ceroid lipofuscinosis with granular osmiophilic deposits (OMIM:600680). palmitoyl-protein thioesterase precursor Lund et al 2002 Fig1 aging-regulated genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F44E2.3 Aff_F44E2.3 F44E2.3; 3J918; CE00181; WBGene00018417; WP:CE00181 DnaJ Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F44E5.2 Aff_F44E5.2 F44E5.2; 2M63; CE18677; WBGene00009689; WP:CE18677 Leucine Rich Repeat (2 copies) F45C12.11 Aff_F45C12.11 bath-32; sdz-18; F45C12.11; 2B994; CE10456; WBGene00018442; WP:CE10456 ViswanathanM et al 2005 S2 sir-2.1 regulated F45C12.13 Aff_F45C12.13 fbxb-48; F45C12.13; 2C6; CE10460; WBGene00018444; WP:CE10460 F45C12.14 Aff_F45C12.14 fbxb-5; F45C12.14; 2C8; CE36850; WBGene00018445; WP:CE36850 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F45C12.6 Aff_F45C12.6 F45C12.6; 2C13; CE10446; WBGene00018437; WP:CE10446 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F45D11.13 Aff_F45D11_40.E fbxb-30; F45D11.13; 2B292; CE35933; WBGene00018458; WP:CE35933 F45D11.6 Aff_F45D11_40.H F45D11.6; 2B289; CE35935; WBGene00018453; WP:CE35935 F45E1.6 Aff_F45E1.6 his-71; F45E1.6; F45E1.6.1; F45E1.6.2; CE01943; NM_076943; WBGene00001945; WP:CE01943; XI600 his-71 encodes an H3 histone required for embryonic viability, body morphology, and larval viability. Histone H3 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F45F2.3 Aff_F45F2.3 his-5; F45F2.3; 5J15; NM_072799; WBGene00001879 his-5 encodes an H4 histone. histone H4 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F45F2.4 Aff_F45F2.4 his-7; F45F2.4; 5J13; NM_072797; WBGene00001881 his-7 encodes an H2A histone. histone H2A Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated F46E10.2 Aff_F46E10.J F46E10.2; F46E10.2.1; F46E10.2.2; F46E10.C; F46E10.H; F46E10.J; 5H1; CE20813; WBGene00018489; WP:CE20813 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Zhang et al 2002, T1 mec-3 dependent genes F46H5.4 Aff_F46H5.4 F46H5.4; CE04590; WBGene00018520; WP:CE04590; XH864 Rat trg gene product McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol F47B10.1 Aff_F47B10.1 F47B10.1; F47B10.1.1; F47B10.1.2; CE03351; SCB1; WBGene00009812; WP:CE03351; XL516 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. succinate-CoA ligase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F47B7.1 Aff_F47B7.1 F47B7.1; F47B7.1.1; F47B7.1.2; CE02743; WBGene00018532; WP:CE02743; XE407 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination F47B7.2 Aff_F47B7.2 F47B7.2; CE04599; CE28394; CE28395; WBGene00018533; WP:CE04599; WP:CE28394; WP:CE28395; XE395 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F47D12.3 Aff_F47D12.3 F47D12.3; 3H389; CE01947; WBGene00018560; WP:CE01947 ViswanathanM et al 2005 S2 sir-2.1 regulated F47D12.5 Aff_F47D12.5 F47D12.5; 3H372; CE01949; WBGene00018561; WP:CE01949 Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F48E3.3 Aff_F48E3.3 F48E3.3; CE02751; WBGene00018604; WP:CE02751; XI114 killer toxin-resistance protein (S. cerevisiae) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F48F7.4 Aff_F48F7.4 pqn-39; F48F7.4; CE05891; NM_077924; WBGene00004126; WP:CE05891; XO584 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). ViswanathanM et al 2005 S2 sir-2.1 regulated F49B2.1 Aff_F49B2.1 fbxb-8; F49B2.1; 1O891; CE28559; WBGene00009861; WP:CE28559 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Lund et al 2002 Fig1 aging-regulated genes F49H12.1 Aff_F49H12.I lsy-2; F49H12.1; F49H12.1b.1; F49H12.1b.2; CE28437; CE38521; NM_075984; WBGene00003087; WP:CE28437; WP:CE38521; XC711 C2H2-type zinc finger protein ViswanathanM et al 2005 S2 sir-2.1 regulated F52B5.5 Aff_F52B5.5 F52B5.5; F52B5.5a.1; F52B5.5a.2; F52B5.5b.1; F52B5.5b.2; 1I901; CE29805; CE38369; NM_059861; WBGene00000467; WP:CE29805; WP:CE38369 cep-1 encodes an ortholog of the human tumor suppressor p53 (OMIM:191170, mutated in Li-Fraumeni syndrome) that promotes DNA damage-induced apoptosis and is required for normal meiotic segregation in the germ line, and affects sensitivity to hypoxia-induced lethality and longevity in response to starvation; CEP-1 is expressed ubiquitously in embryos and in the nucleoli of a subset of pharyngeal cells. Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster E, Wang et al 2003 S6 removed genes of contamination F52C9.8 Aff_F52C9.4 pqe-1; F52C9.8; F52C9.8d.1; F52C9.8d.2; 3G411; CE30672; CE30673; CE30674; CE30675; CE30802; CE30998; CE39256; NM_065734; NM_065735; NM_065736; NM_171119; NM_171120; NM_171864; WBGene00004095; WP:CE30672; WP:CE30673; WP:CE30674; WP:CE30675; WP:CE30802; WP:CE30998; WP:CE39256 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes F52D1.1 Aff_F52D1.1 F52D1.1; CE38522; WBGene00018682; WP:CE38522; XB85 acid alpha-glucosidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F52E10.1 Aff_F52E10.1 egl-16; sdc-1; F52E10.1; CE03393; NM_078249; WBGene00004745; WP:CE03393; XQ895 sdc-1 encodes a zinc-finger protein of the C2H2-type that affects egg laying and vulval development, and hermaphrodite sex determination; expressed at highest levels in embryos and in adults. Zinc finger, C2H2 type (3 domains) Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E F52E4.8 Aff_F32E4.8 F32E4.8; F52E4.8; CE09875; WBGene00018704; WP:CE09875; XD718 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F52G3.4 Aff_F52G3.4 F52G3.4; CE10860; WBGene00018712; WP:CE10860; XR560 F52H3.5 Aff_F52H3.5 F52H3.5; 2K321; CE03401; WBGene00009947; WP:CE03401 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F53A2.3 Aff_F53A2.3 F53A2.3; 3O426; CE16095; WBGene00009951; WP:CE16095 ViswanathanM et al 2005 S2 sir-2.1 regulated F53A3.3 Aff_F53A3.3 rps-22; F53A3.3; F53A3.3.1; F53A3.3.2; F53A3.3.3; 3D39; CE10884; NM_065080; WBGene00004491; WP:CE10884 rps-22 encodes a small ribosomal subunit S15a protein. 40S ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F53B2.6 Aff_F53B2.6 ham-1; F53B2.6; 4N309; CE17851; NM_070000; WBGene00001820; WP:CE17851 ham-1 encodes a novel protein with a winged helix DNA-binding motif; ham-1 is required for the asymmetric divisions of several neuroblasts in the developing embryo and may influence their spindle position; ham-1 mutations also exhibit HSN motor neuron migration defects; HAM-1 interacts with itself in a yeast two-hybrid screen and observations suggest that its multimerization is required for its proper localization; HAM-1 is cytoplasmic and is asymmetrically distributed to the posterior of the HSNPHB neuroblast. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F53B3.1 Aff_F53B3.1 F53B3.1; CE28444; WBGene00018740; WP:CE28444; XD472 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F53B7.3 Aff_F53B7.3 F53B7.3; 5L480; CE05922; WBGene00009966; WP:CE05922 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F53C3.11 Aff_F53C3.11 F53C3.11; 2E196; CE19449; WBGene00018754; WP:CE19449 F53F4.11 Aff_F53F4.11 F53F4.11; F53F4.11.1; F53F4.11.2; 5O104; CE20849; WBGene00009993; WP:CE20849 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F53F4.14 Aff_F53F4.14 F53F4.14; F53F4.14.1; F53F4.14.2; 5O109; CE29593; WBGene00009996; WP:CE29593 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E F53F8.3 Aff_F53F8.3 F53F8.3; 5V158; CE17857; WBGene00010000; WP:CE17857 Zinc finger, C3HC4 type (RING finger) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F53G12.10 Aff_F53G12.10 rpl-7; F53G12.10; F53G12.10.1; F53G12.10.2; 1A583; CE11024; NM_058275; WBGene00004418; WP:CE11024 rpl-7 encodes a large ribosomal subunit L7 protein required in mass RNAi assays for embryonic viability and normally rapid growth. ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F53H1.4 Aff_F53H1.4 F53H1.4; 4C91; CE31539; CE33651; CE33652; WBGene00018778; WP:CE31539; WP:CE33651; WP:CE33652 F53H2.3 Aff_F53H2.3 F53H2.3; 5U866; CE19888; WBGene00010006; WP:CE19888 F53H4.3 Aff_F53H4.3 F53H4.3; CE11032; WBGene00010008; WP:CE11032; XQ504 ViswanathanM et al 2005 S2 sir-2.1 regulated F53H8.3 Aff_F53H8.3 F53H8.3; CE04656; WBGene00018779; WP:CE04656; XB557 glucose transporter Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F53H8.4 Aff_F53H8.4 sms-2; F53H8.4; CE04657; NM_075781; WBGene00004893; WP:CE04657; XB564 F54C4.4 Aff_F54C4.4 F54C4.4; 3A704; CE19893; WBGene00018795; WP:CE19893 F54C9.5 Aff_F54C9.5 rpl-5; F54C9.5; F54C9.5.1; F54C9.5.2; 2I861; CE02255; NM_063410; WBGene00004416; WP:CE02255 rpl-5 encodes a large ribosomal subunit L5 protein; by homology, RPL-5 is predicted to function in protein biosynthesis; in C. elegans RPL-5 activity is broadly required for embryonic, larval, germline, and vulval development, as well as normal body coloration, morphology, and postembryonic growth rates. 60S ribosomal protein L5 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F54D10.2 Aff_F54D10.2 fbxa-24; F54D10.2; 2E107; CE32677; WBGene00018803; WP:CE32677 Lund et al 2002 Fig1 aging-regulated genes, Lund et al 2002 Fig4 Mount 15, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F54D11.1 Aff_F54D11.1 F54D11.1; 5F113; CE11068; WBGene00018811; WP:CE11068 ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F54D7.2 Aff_F54D7.2 F54D7.2; 1F377; CE36936; WBGene00018797; WP:CE36936 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F54D8.1 Aff_F54D8.1 dpy-17; F54D8.1; F54D8.1.1; F54D8.1.2; 3G197; CE11066; NM_065685; WBGene00001076; WBGene00018799; WP:CE11066 Uncloned locus that affects body length and outgrowth of posterior canal cell processes. Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F54E12.1 Aff_F54E12.1 his-55; F54E12.1; 4M102; NM_069737; WBGene00001929 his-55 encodes an H3 histone; by homology, HIS-55 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-55 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV. histone H3 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F54F7.1 Aff_F54F7.1 TAF-8.1; taf-7.1; F54F7.1; CE03416; NM_077575; WBGene00006388; WP:CE03416; XM454 The taf-7.1 gene encodes an ortholog of mammalian TATA-binding protein associated factor TAF7L (TAFIIQ, OMIM:300314) that in mice exhibits testis-specific expression; TAF-7 function in C. elegans is not yet known, as taf-7 inactivation by RNA interference does not result in any obvious developmental defects. McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma F55A12.7 Aff_F55A12.7 apm-1; F55A12.7; 1F912; CE30145; NM_059171; WBGene00000150; WP:CE30145 The apm-1 gene encodes an adaptin: specifically, it encodes an ortholog of the mu1-II subunit of adaptor protein complex 1 (AP-1). clathrin coat assembly protein complex 1 medium chain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol F55A4.8 Aff_F55A4.8 F55A4.8; F55A4.8c.1; F55A4.8c.2; CE19463; CE31182; CE31183; WBGene00018860; WP:CE19463; WP:CE31182; WP:CE31183; XB658 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F55A8.1 Aff_Y48A5B.B egl-18; elt-5; pvl-3; F55A8.1; F55A8.1.1; F55A8.1.2; F55A8.1.3; 4C681; CE28339; NM_067742; WBGene00001186; WP:CE28339 egl-18 encodes a member of the GATA-family of transcription factors that affects cell migration, cell fate specification; expressed in the head, in hypodermal seam cells, VC neurons, and vulval precursor cells. zinc finger protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F55C9.1 Aff_F55C9.1 fbxb-117; F55C9.1; 5T759; CE18733; WBGene00010099; WP:CE18733 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F55C9.10 Aff_F55C9.10 fbxb-61; F55C9.10; 5T775; CE18742; WBGene00010106; WP:CE18742 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F55C9.13 Aff_F55C9.9 fbxb-63; F55C9.13; F55C9.9; CE18741; WBGene00044197; WP:CE18741 ViswanathanM et al 2005 S2 sir-2.1 regulated F55C9.5 Aff_F55C9.5 F55C9.5; 5T764; CE18737; WBGene00010102; WP:CE18737 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F55D10.2 Aff_F55D10.2 rpl-25.1; F55D10.2; F55D10.2.1; F55D10.2.2; CE02777; NM_076407; WBGene00004438; WP:CE02777; XF335 rpl-25.1 encodes a large ribosomal subunit L23a protein. Ribosomal protein L23 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F55D10.3 Aff_F55D10.3 glit-1; F55D10.3; CE04659; NM_076406; WBGene00018878; WP:CE04659; XF333 Esterase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F55G1.10 Aff_F55G1.10 his-61; F55G1.10; 4I250; NM_068800; WBGene00001935 his-61 encodes an H2A histone. Histone ViswanathanM et al 2005 S2 sir-2.1 regulated F55G1.2 Aff_F55G1.2 his-59; F55G1.2; 4I253; NM_068803; WBGene00001933 his-59 encodes an H3 histone; by homology, HIS-59 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-59 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV. Histone Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories F55G7.2 Aff_F55G7.2 F55G7.2; CE03424; WBGene00010120; WP:CE03424; XM546 F55H12.5 Aff_F55H12.2 F55H12.5; 1J447; CE32441; WBGene00010136; WP:CE32441 Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, shared sperm F56A12.1 Aff_F56A12.1 mig-3; unc-39; F56A12.1; 5O855; CE37921; NM_074162; WBGene00006775; WP:CE37921 unc-39 encodes a homeodomain transcription factor that belongs to the Six4/5 family of homeodomain proteins that includes human Six5; UNC-39 is required for axonal pathfinding in anterior-derived neurons and for specification of most mesodermal cell types and may regulate a developmental decision between migration and differentiation; UNC-39 is expressed in the embryo in anterior neurons, posteriorly derived mesoderm (somatic gonad, M mesoblast, and possibly the coelomocytes and muIntR), the CAN neurons, and body wall muscle. so class homeobox protein ViswanathanM et al 2005 S2 sir-2.1 regulated F56A4.12 Aff_F56A4.A, Aff_Y19D10A.F F56A4.12; 5C954; CE25010; WBGene00018920; WP:CE25010 ViswanathanM et al 2005 S2 sir-2.1 regulated F56A8.4 Aff_F56A8.4 F56A8.4; 3O353; CE16124; WBGene00010140; WP:CE16124 Jones et al 2001 Dauer specific genes P<0.05, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F56B3.2 Aff_F56B3.2 F56B3.2; 4B518; CE29402; CE31545; WBGene00018928; WP:CE29402; WP:CE31545 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56B6.2 Aff_F56B6.2 rgs-7; F56B6.2; CE29403; CE29404; CE30151; CE39019; NM_076209; WBGene00004350; WBGene00018936; WP:CE29403; WP:CE29404; WP:CE30151; WP:CE39019; XE175 F56B6.2 encodes three isoforms of an atypical regulator of G protein signaling (RGS) protein that contains both a C2 and an RGS domain, and that binds EGL-30 via both domains, similar in organization to mammalian PDZ-RGS3; the RGS domain has GTPase activator protein (GAP) activity in vitro on mammalian G[alphai]3; F56B6.2 thus may stably bind EGL-30 at all stages of EGL-30's GTPase cycle, might organize EGL-30 into a stable multiprotein signalling complex (with GTP[gamma]S), and might persistently inhibit EGL-30 when triggered by calcium or phospholipids; F56B6.2 has no obvious function in mass RNAi assays Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56F3.2 Aff_F56F3.2 ndg-4; F56F3.2; 3F554; CE01015; CE33658; NM_065506; WBGene00003577; WP:CE01015; WP:CE33658 Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56F3.5 Aff_F56F3.5 rps-1; F56F3.5; F56F3.5.1; F56F3.5.2; 3F565; CE00664; NM_065509; WBGene00004470; WP:CE00664 rps-1 encodes a small ribosomal subunit S3A protein. Ribosomal protein S3a (human) homolog. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F56H6.2 Aff_F56H6.2 F56H6.2; 1M871; CE28567; WBGene00010163; WP:CE28567 F57B10.11 Aff_F57B10.11 bag-1; F57B10.11; 1H140; CE11318; NM_059492; WBGene00000236; WP:CE11318 A homolog of the human BAG-family of co-chaperone proteins, negatively regulates Hsp70 and affects cell stress and cell growth. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F57B10.4 Aff_F57B10.4 F57B10.4; 1H143; CE11304; WBGene00019002; WP:CE11304 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F57B10.6 Aff_F57B10.6 F57B10.6; 1H135; CE11308; WBGene00019004; WP:CE11308 F57B10.6 is orthologous to the human gene EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 5 (XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G (COCKAYNE SYNDROME)) (ERCC5; OMIM:133530), which when mutated leads to disease. DNA repair protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F57C9.4 Aff_F57C9.4 F57C9.4; 1F403; CE28474; CE28475; WBGene00019011; WP:CE28474; WP:CE28475 Reinke et al 2004, intrinsic, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F57F5.4 Aff_F57F5.4 add-2; F57F5.4; F57F5.4.1; F57F5.4.2; 5M490; CE06002; NM_073612; WBGene00000073; WP:CE06002 add-2 encodes a protein containing an alpha-adducin-like head domain that while highly similar in sequence to the head domain of vertebrate and Drosophila adducins, atypically resides at the C-, rather than N-, terminus of the protein; by homology, ADD-2 is predicted to be a cell membrane-associated cytoskeletal protein that mediates cytoskeletal rearrangements in response to activation of signal transduction cascades; as loss of add-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of ADD-2 in C. elegans development and/or behavior is not yet known. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F58A4.4 Aff_F58A4.4 pri-1; F58A4.4; 3K702; CE00220; NM_066725; WBGene00004180; WP:CE00220 pri-1 encodes a homolog of the DNA polymerase alpha-primase subunit D that is required in embryos for the normal timing of embryonic cell divisions, much as DIV-1 is. DNA primase 49Kd subunit McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F58E1.10 Aff_F58E1.10 F58E1.10; 2B980; CE11390; WBGene00019041; WP:CE11390 Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F58E1.11 Aff_F58E1.11 F58E1.11; 2B982; CE36171; WBGene00019042; WP:CE36171 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol F58E1.12 Aff_F58E1.12 F58E1.12; 2B984; CE11394; WBGene00019043; WP:CE11394 Reinke et al 2004, list of genes in cluster order, Romagnolo et al 2002 Fig3b Unkown F58E1.14 Aff_F58E1.14 fbxb-47; F58E1.14; 2B992; CE11398; WBGene00019045; WP:CE11398 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol F58E1.3 Aff_F58E1.3 fbxb-26; F58E1.3; 2B971; CE11376; WBGene00019035; WP:CE11376 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated F58E1.9 Aff_F58E1.9 fbxb-19; F58E1.9; 2B976; CE11388; WBGene00019040; WP:CE11388 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F58E10.2 Aff_F58E10.2 end-1; F58E10.2; 5O467; CE18784; NM_074074; WBGene00001310; WP:CE18784 end-1 encodes a GATA-like transcription factor sufficient to initiate endoderm differentiation and binds to the canonical target DNA sequence WGATAR with specificity similar to GATA-1 and D4 transcription factors; its expression bypasses requirement for maternal SKN-1 and the maternal Wnt signaling pathway in endoderm formation and it activates endoderm differentiation in isolated Xenopus ectoderm. GATA family of transcription factors Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F58E10.5 Aff_F58E10.5 end-3; F58E10.5; 5O495; CE18787; NM_074079; WBGene00001311; WP:CE18787 end-3 encodes a GATA zinc finger protein, paralogous to end-1, that helps specify mesoendodermal (as opposed to mesectodermal) lineages derived from the E blastomere. GATA family of transcription factors F58E10.7 Aff_F58E10.7 F58E10.7; 5O473; CE18789; WBGene00010262; WP:CE18789 Reinke et al 2004, IVb male soma enriched genes, Romagnolo et al 2002 Fig3b Unkown, Romagnolo et al 2002 Fig5 genes in let-60 timecour, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F59A1.10 Aff_F59A1.10 F59A1.10; 5S141; CE18794; WBGene00010296; WP:CE18794 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen F59A2.4 Aff_F59A2.4 F59A2.4; 3E489; CE17941; CE39740; WBGene00010304; WP:CE17941; WP:CE39740 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F59A6.5 Aff_F59A6.5 F59A6.5; 2F293; CE02790; WBGene00019087; WP:CE02790 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E F59A7.4 Aff_F59A7.4 hil-6; F59A7.4; H1.6; 5C506; CE11442; NM_071153; WBGene00001857; WP:CE11442 histone H1 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F59B2.3 Aff_F59B2.3 F59B2.3; 3K88; CE00231; WBGene00010308; WP:CE00231 N-acetyl-glucosamine-6-phosphate deacetylase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F59C6.5 Aff_F59C6.5 F59C6.5; F59C6.5.1; F59C6.5.2; 1L97; CE11464; WBGene00010326; WP:CE11464 NADH ubiquinone oxidoreductase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Oxidation, ViswanathanM et al 2005 S2 sir-2.1 regulated F59E10.2 Aff_F59E10.2 cyn-4; cyp-4; mog-6; F59E10.2; 2L162; CE01596; NM_063936; WBGene00000880; WP:CE01596 cyp-4 encodes a peptidyl-propyl cis-trans isomerase of the cyclophilin family that is required for sexual differentiation of germ cells in hermaphrodites and affects body-wall muscle cell development; expression is most abundant in early larval stages and is observed exclusively in body- wall striated muscle cells. cyclophilin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 daf-16 Resveratrol H06I04.4 Aff_Y53G8B_1025.B ubl-1; H06I04.4; H06I04.4a.1; H06I04.4a.2; H06I04.4a.3; H06I04.4b.1; H06I04.4b.2; 3E159; CE20938; CE31022; NM_171089; WBGene00006725; WP:CE20938; WP:CE31022 ubl-1 encodes a protein similar to Drosophila ubiquitin/ ribosomal protein S27a that affects body length, fertility, and larval viability. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated H24O09.2 Aff_H24O09.B fbxb-72; H24O09.2; 5B202; CE23825; WBGene00019243; WP:CE23825 Reinke et al 2004, male sperm, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, mixed sperm soma, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, fem3 enriched genes H28G03.2 Aff_H28G03.2 H28G03.2; H28G03.2c.1; H28G03.2c.2; CE29419; CE31191; CE31192; WBGene00019250; WP:CE29419; WP:CE31191; WP:CE31192; XF833 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 H38K22.2 Aff_H38K22.2 dcn-1; H38K22.2; 3F405; CE33527; CE33528; NM_065465; NM_065466; WBGene00010428; WP:CE33527; WP:CE33528 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated H40L08.1 Aff_H40L08.1 H40L08.1; CE16188; WBGene00010433; WP:CE16188; XP700 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K01A2.5 Aff_K01A2.5 K01A2.5; 2A593; CE19513; WBGene00019280; WP:CE19513 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 K01C8.9 Aff_K01C8.9 nst-1; K01C8.9; 2I572; CE02270; NM_063348; WBGene00003821; WP:CE02270 nst-1 encodes a homolog of human FLJ10613 and nucleostemin (OMIM:608011); nucleostemin is a nucleolar protein found in stem cells that is required in quantitatively correct amounts (neither too little nor too much) for continued cell division and survival by stem cells or transformed cells; NST-1 is required in mass RNAi assays for normally rapid growth, larval viability, and normal body morphology and pigmentation; it is thus possible that NST-1 acts in the nucleolus to maintain cell proliferation. GTP-binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K01D12.13 Aff_K01D12.13 cdr-7; K01D12.13; 5M890; CE38388; CE38389; WBGene00010472; WP:CE38388; WP:CE38389 glutathione S-transferase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b Oxidation, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K02B12.8 Aff_K02B12.8 zhp-3; K02B12.8; 1J106; CE34201; NM_059910; WBGene00006976; WP:CE34201 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E K02B2.5 Aff_K02B2.5 rps-25; K02B2.5; K02B2.5.1; K02B2.5.2; 4G712; CE04691; NM_068494; WBGene00004494; WP:CE04691 rps-25 encodes a small ribosomal subunit S25 protein. ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K02E2.4 Aff_K02E2.4 ins-35; K02E2.4; 5U845; CE18839; NM_075525; WBGene00002118; WP:CE18839 ins-35 encodes one of several insulin-related peptides. Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order K02E7.5 Aff_K02E7.5 K02E7.5; 2B353; CE33416; WBGene00019310; WP:CE33416 K02F2.3 Aff_K02F2.3 phi-6; tag-203; K02F2.3; 1H409; CE17155; WBGene00019323; WP:CE17155 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA K02F2.6 Aff_K02F2.6 ser-3; K02F2.6; 1H400; CE17158; NM_059553; WBGene00004778; WP:CE17158 ser-3 encodes a predicted G protein-coupled receptor that is a candidate metabotropic serotonin receptor; SER-3 activity is required for fertility and for embryonic development; to date, SER-3 expression has been detected in the pharynx. seven trans-membrane receptor ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 K03A1.6 Aff_K03A1.6 his-38; K03A1.6; NM_076830; WBGene00001912; XH928 his-38 encodes an H4 histone; by homology, HIS-38 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-38 is a replication-dependent histone locus that does not reside in a cluster, but exists as a single histone locus on the X chromosome. histone-H4 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated K03B8.4 Aff_K03B8.4 K03B8.4; 5L872; CE06078; WBGene00010523; WP:CE06078 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K03H1.7 Aff_K03H1.7 K03H1.7; 3L37; CE00573; WBGene00010542; WP:CE00573 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K04C1.3 Aff_K04C1.3 K04C1.3; K04C1.3.1; K04C1.3.2; CE06087; WBGene00010553; WP:CE06087; XO860 Zinc finger, C2H2 type Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated K04G7.11 Aff_K04G7.12 K04G7.11; 3I250; CE39587; WBGene00019402; WP:CE39587 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol K04H4.6 Aff_K04H4.6 crn-6; K04H4.6; 3K459; CE25043; CE31813; NM_066660; NM_066661; WBGene00000799; WP:CE25043; WP:CE31813; YMV6 K05F1.5 Aff_K05F1.4 K05F1.5; 2G83; CE28587; WBGene00019407; WP:CE28587 K05F6.1 Aff_K05F6.1 fbxb-49; K05F6.1; 2B861; CE17159; WBGene00019412; WP:CE17159 ViswanathanM et al 2005 S2 daf-16 Resveratrol K05F6.4 Aff_K05F6.4 K05F6.4; 2B837; CE17162; WBGene00019415; WP:CE17162 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K05F6.9 Aff_K05F6.9 fbxb-46; K05F6.9; 2B858; CE17167; WBGene00019420; WP:CE17167 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 daf-16 Resveratrol K06A5.4 Aff_K06A5.4 K06A5.4; 1H39; CE26645; WBGene00019432; WP:CE26645 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K06G5.2 Aff_K06G5.2 cyp-13B2; K06G5.2; CE37720; NM_077968; WBGene00010606; WP:CE37720; XO845 Cytochrome P450 Menzel et al 2001 T3 CYP genes, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E K06H7.4 Aff_K06H7.4 grp-1; K06H7.4; K06H7.4.1; K06H7.4.2; 3J177; CE26942; NM_066363; WBGene00001743; WP:CE26942 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. sec7 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated K07A1.12 Aff_K07A1.12 lin-53; rba-2; K07A1.12; K07A1.12.1; K07A1.12.2; 1K196; CE16234; NM_060151; WBGene00003036; WP:CE16234 chromatin assembly factor 1 P55 subunit like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K07C5.3 Aff_K07C5.3 K07C5.3; 5K825; CE06113; WBGene00010626; WP:CE06113 DNA ligase like domain Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated K07C5.5 Aff_K07C5.5 K07C5.5; 5K836; CE06115; WBGene00010628; WP:CE06115 hydrolase ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 K07E3.2 Aff_K07E3.2 K07E3.2; CE39594; WBGene00019491; WP:CE39594; XI727 Lund et al 2002 Fig1 aging-regulated genes, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated K07E3.3 Aff_K07E3.3 dao-3; K07E3.3; CE25047; NM_076961; WBGene00000929; WP:CE25047; XI704 dao-3 encodes a protein containing a tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; expression is regulated by DAF-2. methylenetetrahydrofolate dehydrogenase Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination K07E3.4 Aff_K07E3.4 K07E3.4; CE18020; WBGene00019492; WP:CE18020; XI700 tetrahydrofolate synthase ViswanathanM et al 2005 S2 sir-2.1 regulated K07F5.1 Aff_K07F5.1 msp-81; K07F5.1; 4K600; NM_069358; WBGene00003467 msp-81 encodes a member of the major sperm protein family. major sperm protein K07F5.2 Aff_K07F5.2 msp-10; K07F5.2; 4K603; CE03853; NM_069359; WBGene00003425; WP:CE03853 msp-10 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm K08B12.2 Aff_K08B12.2 K08B12.2; 5G731; CE29814; CE30817; WBGene00019521; WP:CE29814; WP:CE30817 K08B5.1 Aff_K08B5.1 K08B5.1; CE35740; WBGene00019518; WP:CE35740; XR175 Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K08C7.3 Aff_K08C7.3 egf-3; epi-1; lgx-3; K08C7.3; 4L443; CE06136; CE25049; NM_069569; WBGene00001328; WP:CE06136; WP:CE25049 epi-1 encodes a laminin alpha chain that affects oogenesis due to its affect on gonad development, and also affects cell migrations, axon extension and GABAergic defasciculation, morphology of the VD and DD motor neurons, body morphology, locomotion, gonad sheath epithelialization, body muscle structure, and germ cell proliferation. laminin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K08D10.3 Aff_K08D10.3 rnp-3; K08D10.3; 4E939; CE07355; NM_068104; WBGene00004386; WP:CE07355 U1 small nuclear ribonucleoprotein A McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K08D10.8 Aff_K08D10.8 K08D10.8; K08D10.8.1; K08D10.8.2; 4E929; CE07360; WBGene00019531; WP:CE07360 K08D10.7 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; a close paralog of K08D10.8 is K08D10.7, and other paralogs include F46A8.9, F46A8.10, and Y50E8A.9> Exposure of phosphatidylserine on the surface of apoptotic cells occurs because of a phospholipid scramblase and inactivation of an aminophospolipid translocase that would normally keep the PS on the interior of the cell; by virtue of its similarity to mammalian scramblase, K08D10.8 may promote clearage of apoptotic cells by phagocytosis. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 sir-2.1 regulated K08F4.1 Aff_K08F4.1 K08F4.1; K08F4.1.1; K08F4.1.2; 4K888; CE06149; WBGene00010676; WP:CE06149 Yeast Chl2p like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated K08F4.8 Aff_K08F4.8 msp-38; K08F4.8; 4K908; CE06156; NM_069448; WBGene00003434; WP:CE06156 msp-38 encodes a member of the major sperm protein family; msp-38 has a C. briggsae homolog as predicted by the Wobble Bulk Aware Bulk Aligner (WABA). major sperm protein MSP-38 K09A11.1 Aff_K09A11.1 K09A11.1; CE31558; WBGene00010704; WP:CE31558; XN881 transposase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories K09C6.6 Aff_K09C6.6 K09C6.6; 5B323; CE11998; WBGene00019560; WP:CE11998 K09F6.8 Aff_K09F6.8 K09F6.8; 2C584; CE12038; WBGene00019591; WP:CE12038 ViswanathanM et al 2005 S2 sir-2.1 regulated K10B3.10 Aff_K10B3.10 imo-1; spc-1; K10B3.10; CE07373; NM_076136; WBGene00004951; WP:CE07373; XD738 spectrin alpha chain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C K10B4.6 Aff_K10B4.6 Wnt-1; cwn-1; K10B4.6; 2A422; CE12072; CE33421; WBGene00000857; WP:CE12072; WP:CE33421 cwn-1 encodes one of five C. elegans Wnt signaling ligands; although the precise developmental role of cwn-1 is not yet known, during embryogenesis cwn-1 likely functions as a downstream target of the PAL-1 homeodomain protein in the regulatory network that specifies cell fates in the C lineage that gives rise to ectodermal and muscle tissue; consistent with this role, loss of cwn-1 activity via RNAi results in rare larval tail defects that may result, in part, from abnormal morphogenesis of C lineage descendants; a cwn-1 reporter is expressed in C and D muscle cells, as well as in two posterior C ectodermal cells; cwn-1 mRNA is detectable at all developmental stages, with highest levels of expression seen in embryonic stages. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes K10C2.4 Aff_K10C2.4 phi-43; K10C2.4; K10C2.4.1; K10C2.4.2; CE04750; WBGene00019620; WP:CE04750; XH66 K10C2.4 is orthologous to the human gene FUMARYLACETOACETATE (FAH; OMIM:276700), which when mutated leads to disease. fumarylacetoacetase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K10D2.7 Aff_K10D2.7 K10D2.7; 3G285; CE02019; WBGene00019633; WP:CE02019 Jones et al 2001 Dauer specific genes P<0.05, Wang et al 2003 S8 SAGE genes in the dauer exit K10D6.4 Aff_K10D6.4 K10D6.4; K10D6.4.1; K10D6.4.2; 5L695; CE36185; WBGene00010744; WP:CE36185 ViswanathanM et al 2005 S2 daf-16 Resveratrol K11D2.3 Aff_K11D2.3 unc-101; K11D2.3; K11D2.3.1; K11D2.3.2; 1N105; CE28050; NM_060773; WBGene00006829; WP:CE28050 unc-101 encodes an adaptin orthologous to the mu1-I subunit of adaptor protein complex 1 (AP-1) that is involved in motility, egg-laying, negative regulation of LET-23 / EGF-receptor signalling, and localization of the neuronal receptors ODR-10 and GLR-1; it is broadly expressed. K11G9.1 Aff_K11G9.1 K11G9.1; 5H159; CE07374; WBGene00019652; WP:CE07374 esterase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 K11H12.7 Aff_K11H12.7 K11H12.7; 4B419; CE12158; WBGene00019663; WP:CE12158 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated K12D12.2 Aff_K12D12.2 npp-3; K12D12.2; K12D12.2.1; K12D12.2.2; 2M156; CE02271; NM_064133; WBGene00003789; WP:CE02271 npp-3 encodes a predicted nucleoporin that is a homolog of vertebrate Nup205, and is required for normal nuclear pore complex distribution in the nuclear envelope, affects nuclear exclusion of large non-nuclear macromolecules, chromatin condensation, early embryonic viability, body integrity and locomotion. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol K12H6.11 Aff_K12H6.11 K12H6.11; 2D109; CE20014; WBGene00019690; WP:CE20014 K12H6.7 Aff_K12H6.7 K12H6.7; 2D126; CE20010; WBGene00019687; WP:CE20010 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol M01D1.1 Aff_M01D1.1 str-148; M01D1.1; 2B337; CE21071; NM_061497; WBGene00006195; WP:CE21071 7TM chemoreceptor, str family M01D1.3 Aff_M01D1.3 M01D1.3; 2B314; CE23871; WBGene00019700; WP:CE23871 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol M01D1.9 Aff_M01D1.9 fbxb-40; M01D1.9; 2B340; CE12258; WBGene00019704; WP:CE12258 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. M01D7.1 Aff_M01D7.1 M01D7.1; 1C330; CE12260; WBGene00019706; WP:CE12260 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 daf-16 Resveratrol M01F1.2 Aff_M01F1.2 rpl-16; M01F1.2; M01F1.2.1; M01F1.2.2; 3E592; CE01030; NM_065320; WBGene00004428; WP:CE01030 rpl-16 encodes a large ribosomal subunit L13a protein. L13P family ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated M01F1.3 Aff_M01F1.3 M01F1.3; M01F1.3.1; M01F1.3.2; M01F1.3.3; CE01031; NM_065321; WBGene00010809; WP:CE01031 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. lipoic acid synthase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated M03B6.4 Aff_M03B6.4 M03B6.4; CE12340; WBGene00010836; WP:CE12340; XO477 ViswanathanM et al 2005 S2 sir-2.1 regulated M03C11.8 Aff_M03C11.8 M03C11.8; 3L518; CE34059; WBGene00010845; WP:CE34059 helicase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated M03F8.3 Aff_M03F8.3 phi-12; M03F8.3; 5G423; CE28622; WBGene00019762; WP:CE28622 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated M04F3.1 Aff_M04F3.1 M04F3.1; M04F3.1.1; M04F3.1.2; 1F339; CE12414; WBGene00019767; WP:CE12414 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated M05B5.5 Aff_M05B5.5 hlh-2; M05B5.5; M05B5.5a.1; M05B5.5a.2; 1H768; CE06191; NM_059633; WBGene00001949; WP:CE06191 hlh-2 encodes a Class I basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the mammalian E and Drosophila Daughterless transcriptional activators; HLH-2 activity is required for cell fate specifications occuring during embryonic and larval development that affect such processes as gonadogenesis, male tail formation, and programmed cell death; HLH-2 has been shown to dimerize with at least two C. elegans Acheate-scute homologs, LIN-32, a neural-specific protein with which it functions in male tail development and HLH-3, with which it is coexpressed in the nuclei of embryonic neuronal prescursors and with which it regulates the transcription of the EGL-1 cell death activator in the NSM sister cells; in gonadogenesis, HLH-2 is required for bestowing proAC competence on the cells that undergo the AC/VU (anchor cell/ventral uterine precursor) cell fate decision, for specification, differentiation, and function of the distal tip cell (DTC) and AC, including transcriptional regulation of the LAG-2 Delta-like ligand in the latter, and for formation of the uterine seam cell (utse); genetic analysis also suggests that HLH-2 functions with HLH-14, an additional Acaete-scute homolog, to specify the PVQ/HSN/PHB neuroblast cell lineage; HLH-2 is expressed in all nuclei of early embryos until the ~200-cell stage, when expression becomes increasingly restricted to neuronal cells and their immediate precursors; later expression is detected in, but not limited to, pharyngeal cells, anterior neurons, vulval and uterine muscles, the DTCs, the presumptive and mature AC, the Q neuroblast, and enteric muscles; comparative analysis of transcriptional and translational reporters indicates that hlh-2 is expressed in both the anchor cell and the ventral uterine (VU) precursor, but that expression in the latter is subject to post-transcriptional down-regulation; HLH-2 accumulation in the presumptive AC is the first detectable difference between the AC and VU precursors during the lateral specification event that distinguishes these two cell fates. transcription factor E2-A like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated M05D6.7 Aff_M05D6.7 gbh-2; M05D6.7; 2I777; CE35896; NM_063392; WBGene00001523; WP:CE35896 gbh-2 encodes an ortholog of human gamma butyrobetaine hydroxilase 2 involved in carnitine biosynthesis; RNA interference of gbh-2 results in malformation of the gonad and accumulation of fat in the pseudocoelomic cavity and in intestinal cells; the GBH-2-GFP fusion protein is predominantly expressed in intestinal cells from early embryogenesis. gamma-butyrobetaine,2-oxoglutarate dioxygenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph M106.1 Aff_M106.1 let-29; mix-1; smc-2; M106.1; R06F6.10; 2L131; CE18083; NM_063930; WBGene00003367; WP:CE18083 The mix-1 gene encodes a homolog of SMC2 involved in chromosome segregation, X-chromosome gene regulation, and repression of X-linked genes during dosage compensation. mitotic chromosome and X-chromosome associated MIX-1 protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated M110.4 Aff_M110.4 ifg-1; M110.4; 2I511; CE02277; CE35745; WBGene00002066; WP:CE02277; WP:CE35745 ifg-1 encodes, by alternative splicing, two orthologs of the translational initiation factor eIF4 (eIF-4) gamma. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph M142.1 Aff_M142.1 unc-119; M142.1; 3L997; CE06203; NM_066998; WBGene00006843; WP:CE06203 unc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated M151.8 Aff_M151.6 fbxb-33; M151.8; CE38623; WBGene00044314; WP:CE38623 M153.1 Aff_M153.1 M153.1; CE03511; WBGene00010924; WP:CE03511; XM767 pyrroline-5-carboxylate reductase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig3b Metabolism, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 LateList M163.3 Aff_M163.3 his-24; M163.3; CE12450; HH1; NM_078009; WBGene00001898; WP:CE12450; XP109 The his-24 gene encodes a histone H1 isoform (H1.1) that is essential for chromatin silencing and germline development. histone H1 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, IVb male soma enriched genes M18.7 Aff_M18.7 aly-3; M18.7; M18.7.1; M18.7.2; 4M889; CE06198; NM_069900; WBGene00000122; WP:CE06198 RNA recognition motif. (aka RRM, RBD, or RNP domain) Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated M57.1 Aff_M57.1 M57.1; 4E303; CE19540; WBGene00019777; WP:CE19540 ViswanathanM et al 2005 S2 sir-2.1 regulated M7.5 Aff_M7.5 M7.5; M7.5.1; M7.5.2; 4L844; CE18887; WBGene00010882; WP:CE18887 Yeast YHX1 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated R01H10.1 Aff_R01H10.1 ccd-1; div-1; R01H10.1; 3L336; CE28840; NM_066867; WBGene00001002; WP:CE28840 div-1 encodes a homolog of the B subunit of the DNA polymerase alpha-primase complex; DIV-1 is required in embryos for the normal timing of interphase in cell divisions, and for the asymmetric distribution of PIE-1 and P granules. DNA polymerase alpha associated subunit McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R02D3.3 Aff_R02D3.3 R02D3.3; R02D3.3.1; R02D3.3.2; 4A980; CE36601; WBGene00019821; WP:CE36601 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R02D3.4 Aff_R02D3.4 R02D3.4; 4A986; CE18098; WBGene00019822; WP:CE18098 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R03E9.2 Aff_R03E9.2 R03E9.2; CE04785; WBGene00019843; WP:CE04785; XH350 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 R03G5.1 Aff_R03G5.1 eft-4; eln-2; R03G5.1; R03G5.1a.1; R03G5.1a.2; R03G5.1a.3; R03G5.1a.4; R03G5.1a.5; R03G5.1c.1; R03G5.1c.2; R03G5.1c.3; CE33153; CE33154; CE33155; NM_076922; NM_182442; NM_182443; NM_182444; WBGene00001169; WP:CE33153; WP:CE33154; WP:CE33155; XI443 eft-4 encodes a translation elongation factor 1-alpha homolog that is required for embryonic viability, fertility, and a normal postembryonic growth rate; eft-4 encodes at least one alternatively spliced coding sequence identical to that of eft-3. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R04B5.5 Aff_R04B5.5 R04B5.5; 5K569; CE06215; WBGene00011003; WP:CE06215 sorbitol dehydrogenase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol R04D3.4 Aff_R04D3.4 R04D3.4; CE06225; WBGene00011012; WP:CE06225; XN906 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R05D11.9 Aff_R05D11.5 R05D11.9; 1J171; CE32474; WBGene00011037; WP:CE32474 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated R06A4.2 Aff_R06A4.2 R06A4.2; R06A4.2.1; R06A4.2.2; 2O649; CE18109; WBGene00011047; WP:CE18109 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol R06C1.1 Aff_R06C1.1 hda-3; R06C1.1; R06C1.1.1; R06C1.1.2; 1M506; CE18116; NM_060625; WBGene00001836; WP:CE18116 hda-3 encodes a member of the histone deacetylase family most similar to human histone deacetylase 1 (HD1) that affects radiation sensitivity. Histone deacetylase family Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes R06C1.4 Aff_R06C1.4 R06C1.4; 1M523; CE18119; WBGene00011059; WP:CE18119 RNA recognition motif. (aka RRM, RBD, or RNP domain) Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA R06C7.3 Aff_R06C7.3 CeCRMP/DHP-1; dhp-1; R06C7.3; R06C7.3.1; R06C7.3.2; 1H816; CE30293; NM_170899; WBGene00000963; WP:CE30293 The R06C7.3 gene encodes a homolog of the human gene DPYS, which when mutated leads to dihydropyrimidinuria (OMIM:222748). dihydropyrimidinase R06C7.7 Aff_R06C7.7 lin-61; rls-1; R06C7.7; R06C7.7.1; R06C7.7.2; 1H826; CE37542; NM_059649; WBGene00003041; WP:CE37542 lin-61 encodes a protein that contains mbt repeats and has similarity to the Drosophila Polycomb group protein Sex Comb on Midleg and human protein H-l-(3)mbl-like; by homology, LIN-61 is predicted to function as part of a transcriptional regulatory complex that may play a role in transcriptional repression during development; loss of lin-61 activity via RNAi and forward mutations indicates that LIN-61 is required for: 1) genome stability in the soma and germline, and 2) postembryonic developmental processes such as vulval development, in which lin-61 acts as a class B synthetic multivulval (SynMuv) gene. Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol R06C7.8 Aff_R06C7.8 bub-1; R06C7.8; 1H831; CE06251; NM_059650; WBGene00000275; WP:CE06251 bub-1 encodes a serine/threonine kinase orthologous to Saccharomyces cerevisiae BUB1 which is required for proper function of the mitotic spindle assembly checkpoint and human BUB1 (OMIM:602452) which is mutated in some colorectal cancers; BUB-1 activity is required at several stages of development, including embryogenesis; BUB-1 is expressed predominantly in the anterior of the embryo and in hypodermal seam cells during the L1 and L2 larval stages. Eukaryotic protein kinase domain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated R06F6.1 Aff_R06F6.1 cdl-1; R06F6.1; R06F6.1.1; R06F6.1.2; 2L75; CE01616; NM_063919; WBGene00000411; WP:CE01616; hbp cdl-1 encodes a homolog of human hairpin (stem-loop) binding proteins (HBP/SLBP) that bind to the hairpin (stem-loop) structure in the 3' untranslated region (3' UTR) of histone mRNAs, and thus promote histone pre-mRNA processing and translation of mature histone mRNA; CDL-1 is required for normally high levels of histone gene expression, normal cell division during late larval development, embryonic viability, normal vulval morphogenesis, normally rapid apoptosis, and fertility; CDL-1 binds to the stem-loop structure in the 3' UTR of core-histone mRNA; the cdl-1 promoter is most active in dividing cells during embryogenesis and postembryonic development; both CDL-1 and human HBP contain a minimal RNA-binding domain (RBD) of roughly 73 amino acids that has no similarity with other known RNA-binding motifs. Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R07B7.10 Aff_R07B7.10 R07B7.10; 5M565; CE35596; WBGene00011094; WP:CE35596 mitochondrial carrier protein ViswanathanM et al 2005 S2 sir-2.1 regulated R07B7.11 Aff_R07B7.11 gana-1; R07B7.11; 5M569; CE06273; NM_073630; WBGene00011095; WP:CE06273 R07B7.11 is orthologous to the human gene ALPHA-GALACTOSIDASE B (GALB; OMIM:104170), which when mutated leads to Schindler disease, Kanzaki disease, or NAGA deficiency. alpha-N-acetylgalactosaminidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig3b Metabolism, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA R07C3.11 Aff_R07C3.11 R07C3.11; 2B196; CE12542; WBGene00019927; WP:CE12542 Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol R07C3.7 Aff_R07C3.7 R07C3.7; 2B207; CE12534; WBGene00019923; WP:CE12534 ViswanathanM et al 2005 S2 sir-2.1 regulated R07C3.8 Aff_R07C3.8 R07C3.8; 2B205; CE12536; WBGene00019924; WP:CE12536 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R07C3.9 Aff_R07C3.9 R07C3.9; 2B203; CE12538; WBGene00019925; WP:CE12538 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R07E5.10 Aff_R07E5.10 pdcd-2; R07E5.10; 3F508; CE18125; WBGene00011116; WP:CE18125 This gene encodes a homolog of mammalian PROGRAMMED CELL DEATH 2 (PDCD2). Apoptosis protein RP-8 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R07E5.3 Aff_R07E5.3 R07E5.3; 3F495; CE01045; WBGene00011111; WP:CE01045 The R07E5.3 gene encodes a homolog of SNF5/Ini1, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; R07E5.3 may be involved in asymmetric cell division of the T cells. Snf5 (yeast) Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R07H5.4 Aff_R07H5.4 sdz-27; R07H5.4; 4L953; CE12556; WBGene00011124; WP:CE12556 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination R07H5.8 Aff_R07H5.8 R07H5.8; R07H5.8.1; R07H5.8.2; 4L974; CE12564; WBGene00011128; WP:CE12564 adenosine kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 R07H5.9 Aff_R07H5.9 R07H5.9; 4L975; CE39953; WBGene00011129; WP:CE39953 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 R08C7.9 Aff_R08C7.9 fbxb-74; R08C7.9; 4F202; CE33682; WBGene00019952; WP:CE33682 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 daf-16 Resveratrol R09A8.3 Aff_R09A8.3 tag-147; R09A8.3; R09A8.3.1; R09A8.3.2; R09A8.3.3; CE03539; WBGene00006493; WP:CE03539; XN244 ring canal like protein ViswanathanM et al 2005 S2 sir-2.1 regulated R09B3.4 Aff_R09B3.4 ubc-12; R09B3.4; 1M503; CE16309; NM_060623; WBGene00006707; WP:CE16309 The ubc-12 gene encodes a ubiquitin-conjugating enzyme whose substrate is NED-8, and which is required for both embryogenesis and terminal hypodermal differentiation; ubc-12(RNAi) mutants either arrest during embryonic development or show pleotropic defects (e.g., vulval eversion during the L4 stage), as well as defective alae. Ubiquitin-conjugating enzymes ViswanathanM et al 2005 S2 sir-2.1 regulated R09B3.5 Aff_R09B3.5 mag-1; R09B3.5; R09B3.5.1; R09B3.5.2; 1M504; CE16310; NM_060624; WBGene00003123; WP:CE16310 MAGO NASHI PROTEIN McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R09E10.7 Aff_R09E10.7 pqn-55; R09E10.7; 4L57; CE37845; NM_069487; WBGene00004140; WP:CE37845 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma R107.8 Aff_R107.8 lin-12; R107.8; 3K150; CE00274; NM_066606; WBGene00003001; WP:CE00274 The lin-12 gene encodes a member of the Notch/LIN-12/glp-1 transmembrane receptor family that affects cell fate specification events during development, notably including the anchor cell, secondary vulval precursor cells, and the embryonic ABplp lineage; its expression is dynamic, including Z1.ppp and Z4.aaa, ABplaa descendants, ABplpa descendants, and the intestinal primordium. LIN-12 protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol R10D12.1 Aff_R10D12.1 R10D12.1; 5O414; CE12672; WBGene00011185; WP:CE12672 sodium/phosphate transporter Reinke et al 2004, IVb male soma enriched genes, Shen et al 2005 T1 hif-1 depend hypoxia, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 R10E12.2 Aff_R10E12.2 R10E12.2; 3L50; CE00311; WBGene00011221; WP:CE00311 ViswanathanM et al 2005 S2 daf-16 Resveratrol R10E4.4 Aff_R10E4.4 mcm-5; R10E4.4; R10E4.4.1; R10E4.4.2; 3F378; CE03558; NM_065457; WBGene00003157; WP:CE03558 CDC46 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated R11A8.4 Aff_R11A8.4 sir-2.1; R11A8.4; R11A8.4.1; R11A8.4.2; 4L128; CE06302; NM_069511; WBGene00004800; WP:CE06302 sir-2.1 encodes a homolog of the S. cerevisiae gene SIR2. Yeast regulatory protein SIR2 like Jones et al 2001 T2 lifespan and Dauer, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 R12B2.4 Aff_R12B2.4 him-10; R12B2.4; 3G893; CE01367; NM_065852; WBGene00001869; WP:CE01367 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen R12E2.15 Aff_R12E2.15 R12E2.15; 1E716; CE18147; WBGene00020040; WP:CE18147 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 R12E2.6 Aff_R12E2.6 R12E2.6; 1E720; CE18138; WBGene00020032; WP:CE18138 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated R12H7.2 Aff_R12H7.2 asp-4; R12H7.2; CE03567; NM_077790; WBGene00000217; WP:CE03567; XN838 asp-4 encodes an aspartyl protease homolog that is required, in parallel with ASP-3 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). aspartyl protease McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R12H7.3 Aff_R12H7.3 skr-19; R12H7.3; CE03568; NM_077792; WBGene00004825; WP:CE03568; XN842 The skr-19 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-19(RNAi) animals are at least superficially normal. RNA polymerase II elongation factor like ViswanathanM et al 2005 S2 sir-2.1 regulated R12H7.5 Aff_R12H7.5 skr-20; R12H7.5; CE06317; NM_077791; WBGene00004826; WP:CE06317; XN840 The skr-20 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-20(RNAi) animals are at least superficially normal. RNA polymerase II elongation factor like ViswanathanM et al 2005 S2 sir-2.1 regulated R13A5.8 Aff_R13A5.8 rpl-9; R13A5.8; R13A5.8.1; R13A5.8.2; 3I662; CE01380; NM_066259; WBGene00004420; WP:CE01380 rpl-9 encodes a large ribosomal subunit L9 protein that affects fertility and embryonic viability. Ribosomal protein L9 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R144.4 Aff_R144.4 R144.4; 3G109; CE34587; CE34588; WBGene00020094; WP:CE34587; WP:CE34588 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R151.2 Aff_R151.2 R151.2; R151.2b.1; R151.2b.2; R151.2b.3; R151.2b.4; R151.2b.5; R151.2d.1; R151.2d.2; 3I303; CE00745; CE29454; CE29987; CE37138; WBGene00020107; WP:CE00745; WP:CE29454; WP:CE29987; WP:CE37138 R151.2 is orthologous to the human gene PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE 1 (PRPS1; OMIM:311850), which when mutated leads to disease Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Romagnolo et al 2002 Fig3b Metabolism, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 R151.3 Aff_R151.3 rpl-6; R151.3; R151.3.1; R151.3.2; 3I299; CE00744; NM_066183; WBGene00004417; WP:CE00744 rpl-6 encodes a large ribosomal subunit L6 protein. Ribosomal protein ML16 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated R151.9 Aff_R151.9 R151.9; 3H288; 3I288; CE00827; WBGene00020112; WP:CE00827 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R155.1 Aff_R155.1 R155.1; R155.1a.1; R155.1a.2; R155.1a.3; R155.1b.1; R155.1b.2; R155.1b.3; 3D42; CE32713; CE33935; WBGene00020115; WP:CE32713; WP:CE33935 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R186.7 Aff_R186.4 R186.7; 5N453; CE27772; WBGene00011308; WP:CE27772 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R53.5 Aff_R53.5 R53.5; 2K260; CE03575; WBGene00011274; WP:CE03575 R74.1 Aff_R74.1 lrs-1; R74.1; R74.1.1; R74.1.2; 3F272; CE16317; NM_065436; WBGene00003073; WP:CE16317 lrs-1 encodes a predicted cytoplasmic leucyl-tRNA synthetase (LeuRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of leucine to its cognate tRNA and is thus required for protein biosynthesis; LRS-1 activity is required for embryonic, larval, and germline development, as well as normal body morphology and rates of postembryonic growth. leucyl-tRNA synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T01C3.6 Aff_T01C3.6 rps-16; T01C3.6; T01C3.6.1; T01C3.6.2; 5P480; CE12918; NM_074289; WBGene00004485; WP:CE12918 rps-16 encodes a small ribosomal subunit S16 protein. 40S ribosomal protein S16 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T01C4.2 Aff_T01C4.2 odr-2; T01C4.2; 5H593; CE28348; CE28349; CE28350; WBGene00003849; WP:CE28348; WP:CE28349; WP:CE28350 odr-2 encodes three isoforms of a predicted membrane-associated protein related to the Ly-6 (leukocyte antigen-6) family of GPI (glycosylated phosphatidylinositol)-linked signaling proteins; ODR-2 activity is required for proper functioning of the AWC olfactory neurons and thus for chemotaxis in response to AWC-sensed odorants; ODR-2 is expressed at high levels in sensory neurons, motor neurons, and interneurons, where it appears to be enriched in axons. T01C8.5 Aff_T01C8.5 T01C8.5; CE07462; WBGene00020146; WP:CE07462; XR406 aminotransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T01G9.4 Aff_T01G9.4 kup-2; npp-2; T01G9.4; 1I868; CE06341; NM_059855; WBGene00003788; WP:CE06341 npp-2 encodes a protein with low similarity to rat nucleoporin Nup75 that affects embryonic viability and has a variety of other defects in RNAi screens including: nuclear morphology, growth, fertility, locomotion, and egg laying; enriched in oocytes. Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T01H8.2 Aff_T01H8.2 T01H8.2; 1J146; CE13016; WBGene00011353; WP:CE13016 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. threonine dehydratase ViswanathanM et al 2005 S2 sir-2.1 regulated T02C1.1 Aff_T02C1.1 T02C1.1; 3K337; CE00312; WBGene00011365; WP:CE00312 Zinc finger, C3HC4 type (RING finger) ViswanathanM et al 2005 S2 daf-16 Resveratrol T02C5.3 Aff_T02C5.3 igcm-3; tag-311; T02C5.3; CE34589; NM_076078; WBGene00020160; WP:CE34589; XD318 Reinke et al 2004, list of genes in cluster order T02G5.1 Aff_T02G5.1 T02G5.1; 2H387; CE04853; WBGene00020161; WP:CE04853 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T02G6.6 Aff_T02G6.6 T02G6.6; 1M413; CE18177; WBGene00011389; WP:CE18177 ViswanathanM et al 2005 S2 sir-2.1 regulated T03D3.5 Aff_T03D3.5 T03D3.5; 5D302; CE33823; WBGene00020183; WP:CE33823 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated T03D8.6 Aff_T03D8.6 T03D8.6; 5V288; CE37271; WBGene00011393; WP:CE37271 Gamma-glutamyltranspeptidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T04B8.3 Aff_T04B8.3 T04B8.3; 2A919; CE39176; WBGene00020205; WP:CE39176 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E T04C12.4 Aff_T04C12.4 act-3; T04C12.4; T04C12.4.1; T04C12.4.2; T04C12.4.3; T04C12.4.4; 5L552; NM_073416; WBGene00000065; act1; act3 act-3 encodes an invertebrate actin, highly similar to ACT-1, ACT-2, and ACT-4, that functions in body wall muscle. actin Golden et al 2004, daf-2 differentially expressed , Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Roy et al 2002 S3 muscle genes T04C9.2 Aff_T04C9.2 T04C9.2; 3H83; CE04877; WBGene00020210; WP:CE04877 T05A12.4 Aff_T22D1.7 T05A12.4; 4H661; CE37666; CE37667; WBGene00020235; WP:CE37666; WP:CE37667 helicase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT T05B11.1 Aff_T05B11.1 T05B11.1; 5I231; CE07464; WBGene00020245; WP:CE07464 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, list of genes in cluster B T05C3.5 Aff_C24G6.5, Aff_T05C3.5 dnj-19; T05C3.5; T05C3.5.1; T05C3.5.2; CE13229; NM_072051; WBGene00001037; WP:CE13229 This gene encodes a protein containing a DnaJ ('J') domain. DNAJ-like protein Lund et al 2002 Aging time course Fig2C heatshock, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated T05E11.1 Aff_T05E11.1 rps-5; T05E11.1; T05E11.1.1; T05E11.1.2; 4L874; CE06360; NM_069676; WBGene00004474; WP:CE06360 rps-5 encodes a small ribosomal subunit S5 protein. 40S ribosomal protein S5 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T05E7.1 Aff_T05E7.1 T05E7.1; 1G781; CE13231; WBGene00020258; WP:CE13231 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 T05E8.3 Aff_T05E8.3 T05E8.3; 1G42; CE37043; WBGene00020263; WP:CE37043 The T05E8.3 gene encodes a divergent DEAH helicase that is (apparently) unique to Caenorhabditis; it has no well-characterized orthologs in the complete Drosophila or S. cerevisiae genomes, and no obvious orthologs in the draft human genome sequence either. helicase Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories T05H10.3 Aff_T05H10.3 T05H10.3; 2I340; CE01640; WBGene00011508; WP:CE01640 T05H10.4 Aff_T05H10.4 T05H10.4; T05H10.4.1; T05H10.4.2; 2I343; CE01641; WBGene00011509; WP:CE01641 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T06C10.4 Aff_T06C10.4 flp-10; T06C10.4; T06C10.4.1; T06C10.4.2; 4I635; CE04902; NM_068905; WBGene00001453; WP:CE04902 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T06E6.1 Aff_T06E6.1 T06E6.1; 5P874; CE13313; WBGene00011538; WP:CE13313 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories T07D1.4 Aff_T07D1.4 fox-1; T07D1.4; T07D1.4.1; T07D1.4.2; CE25105; NM_076045; WBGene00001484; WP:CE25105; XD66 fox-1 encodes an RNA-binding protein of the RNA recognition motif (RRM) superfamily of ribonucleic acid binding proteins; during C. elegans development, FOX-1 functions redundantly with other numerator elements to effect proper dosage compensation in the early embryo; in influencing dosage compensation, FOX-1 likely acts via post-transcriptional regulation of xol-1 mRNA levels; in addition to its role in dosage compensation, fox-1 activity is also required for normal male mating behavior; Western analysis and lacZ reporter constructs indicate that FOX-1 is expressed throughout the life cycle, beginning at the 18-20-cell stage of embryogenesis and continuing on through larval stages and into adult hermaphrodites and males; while early embryonic expression of fox-1 is ubiquitous, postembryonic expression is limited to a subset of head and tail neurons. RNA-binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T07E3.4 Aff_T07E3.4 T07E3.4; T07E3.4a.1; T07E3.4a.2; T07E3.4b.1; T07E3.4b.2; 3H989; CE01385; CE32717; WBGene00020315; WP:CE01385; WP:CE32717 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C T07F10.3 Aff_T07F10.3 T07F10.3; 5N348; CE06396; WBGene00011589; WP:CE06396 polyadenylate-binding protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T08B1.6 Aff_T08B1.6 T08B1.6; 5C451; CE27444; WBGene00020343; WP:CE27444 long-chain fatty-acid CoA ligase Romagnolo et al 2002 Fig3b Metabolism, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 T08B2.10 Aff_T08B2.10 rps-17; T08B2.10; T08B2.10.1; T08B2.10.2; 1G796; CE26948; NM_059394; WBGene00004486; WP:CE26948 rps-17 encodes a small ribosomal subunit S17 protein. 40S ribosomal protein S17 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T08B2.5 Aff_T08B2.6 T08B2.5; 1G795; CE13429; CE25984; CE26949; CE30298; CE33171; CE33172; CE38728; WBGene00020346; WP:CE13429; WP:CE25984; WP:CE26949; WP:CE30298; WP:CE33171; WP:CE33172; WP:CE38728 ViswanathanM et al 2005 S2 sir-2.1 regulated T08D10.1 Aff_T08D10.1 tag-295; T08D10.1; CE03642; WBGene00011614; WP:CE03642; XM564 DNA binding protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T08E11.6 Aff_T08E11.6 fbxb-10; T08E11.6; 2C104; CE19573; WBGene00020362; WP:CE19573 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E T09B4.5 Aff_T09B4.5 T09B4.5; T09B4.5a.1; T09B4.5a.2; 1G733; CE13465; CE33175; WBGene00020379; WP:CE13465; WP:CE33175 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T09B4.8 Aff_T09B4.8 T09B4.8; 1G742; CE33176; WBGene00020382; WP:CE33176 aminotransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T10B11.3 Aff_T10B11.3 ztf-4; T10B11.3; 1H505; CE34364; WBGene00020399; WP:CE34364 RNA-binding Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 T10C6.12 Aff_T10C6.12 his-3; T10C6.12; 5Q521; CE04501; NM_074631; WBGene00001877; WP:CE04501 his-3 encodes an H2A histone; by homology, HIS-3 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-3 is a replication-dependent histone locus that resides in the HIS1 cluster on chromosome V. histone H2A Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated T10C6.14 Aff_T10C6.14 his-1; T10C6.14; 5Q523; CE03252; NM_074633; WBGene00001875; WP:CE03252 his-1 encodes an H4 histone; his-1 is contained within the histone gene cluster HIS1; transcript analysis suggests that it encodes the major class of H4 transcripts. histone H4 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 T10C6.5 Aff_T10C6.5 T10C6.5; 5Q503; CE16380; WBGene00011687; WP:CE16380 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T11B7.1 Aff_T11B7.1 T11B7.1; 4J607; CE23976; WBGene00011706; WP:CE23976 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T11F9.11 Aff_T11F9.11 dhs-19; T11F9.11; 5L970; CE06423; NM_073514; WBGene00000982; WP:CE06423 dhs-19 encodes a short-chain dehydrogenase predicted to be mitochondrial. 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 T12G3.1 Aff_T12G3.1 T12G3.1; T12G3.1.1; T12G3.1.2; 4M801; CE37554; WBGene00011737; WP:CE37554 Drosphila REF (2)P like ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 T12G3.2 Aff_T12G3.2 T12G3.2; T12G3.2a.1; T12G3.2a.2; T12G3.2b.1; T12G3.2b.2; T12G3.2b.3; 4M804; CE06439; CE36199; CE36200; WBGene00011738; WP:CE06439; WP:CE36199; WP:CE36200 The T12G3.2 gene encodes a protein that may be involved in apoptosis. ViswanathanM et al 2005 S2 sir-2.1 regulated T13F2.1 Aff_T13F2.1 fat-4; T13F2.1; T13F2.1.1; T13F2.1.2; T13F2.1.3; 4K565; CE25113; NM_069350; WBGene00001396; WP:CE25113 fat-4 encodes a delta-5 fatty acid desaturase; when expressed heterologously in S. cerevisiae, FAT-4 converts di-homo-gamma-linolenic acid (20:3delta8,11,14) to arachidonic acid (20:4delta5,8,11,14), an important precursor in eicosanoid metabolism, as well as on other fatty acids (C18 to C20); FAT-4 is is required in vivo for delta-5 unsaturated fatty acid synthesis. cytochrome B5 containing fusion protein McElwee et al 2003 T1 targets of daf-16, ViswanathanM et al 2005 S2 sir-2.1 regulated T13F2.11 Aff_T13F2.11 msp-78; T13F2.11; 4K535; CE13638; NM_069341; WBGene00003465; WP:CE13638 msp-78 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated T13F2.7 Aff_T13F2.7 T13F2.7; 4K540; CE13631; WBGene00011747; WP:CE13631 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T13F2.8 Aff_T13F2.8 cav-1; T13F2.8; T13F2.8.1; T13F2.8.2; 4K537; CE13633; NM_069342; WBGene00000301; WP:CE13633 cav-1 encodes a member of the caveolin protein family that affects viability and Ras/MAP-kinase-dependent progression through the meiotic cell cycle meiotic; expressed in the adult germ line and during embryonic development. caveolin Jones et al 2001 Non dauer genes P<0.05, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T13H2.4 Aff_T13H2.4 pqn-65; T13H2.4; CE30179; CE30180; NM_171672; NM_171673; WBGene00004148; WP:CE30179; WP:CE30180; XF230 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma T13H5.4 Aff_T13H5.4 phi-8; T13H5.4; T13H5.4.1; T13H5.4.2; 2I814; CE23981; WBGene00011758; WP:CE23981 PRP9 like protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated T14G8.1 Aff_T14G8.1 chd-3; T14G8.1; CE03657; NM_077739; WBGene00000482; WP:CE03657; XN466 chd-3 encodes a PHD-finger SNF2 family member containing a chromo domain and a C-terminal helicase domain that affects Notch-dependent vulval development; expressed in virtually all embryonic cells and in many larval nuclei. helicase-DNA-binding like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol T14G8.2 Aff_T14G8.2 T14G8.2; CE03658; WBGene00011770; WP:CE03658; XN477 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T14G8.3 Aff_T14G8.3 T14G8.3; CE37407; CE37408; WBGene00011771; WP:CE37407; WP:CE37408; XN487 T14G8.3 encodes an ortholog of hypoxia-upregulated vertebrate proteins such as human HYOU1; T14G8.3, its C. elegans paralog T24H7.2, and HYOU1 are ER resident hsp70 family molecular chaperone homologs; the grp (glucose regulated protein) 170 family is a collection of related large hsp70 chaperones confined to the ER; members of this family are present in all eukaryotes, participating in a wide range of cellular functions. heat shock protein Lund et al 2002 Aging time course Fig2C heatshock, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated T15B7.5 Aff_T15B7.5 col-141; T15B7.5; 5H311; CE13656; NM_072334; WBGene00000714; WP:CE13656 collagen Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T16A1.8 Aff_T16A1.8 fbxb-37; T16A1.8; 2C376; CE13716; WBGene00020537; WP:CE13716 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated T17A3.4 Aff_T17A3.4 fbxb-82; T17A3.4; 3A756; CE19582; WBGene00020542; WP:CE19582 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E T18D3.1 Aff_T18D3.1 T18D3.1; CE03662; WBGene00011820; WP:CE03662; XN75 ViswanathanM et al 2005 S2 sir-2.1 regulated T19B10.2 Aff_T19B10.2 phi-59; T19B10.2; T19B10.2.1; T19B10.2.2; 5L703; CE16413; WBGene00011831; WP:CE16413 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 T19C3.5 Aff_T19C3.5 T19C3.5; 3B242; CE29347; WBGene00020563; WP:CE29347 T19C4.1 Aff_T19C4.1 T19C4.1; 5L629; CE06465; WBGene00011838; WP:CE06465 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T19H12.1 Aff_T19H12.1 ugt-9; T19H12.1; 5F375; CE13752; WBGene00020587; WP:CE13752 7TM chemoreceptor, ugt family Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Romagnolo et al 2002 Fig5 genes in let-60 timecour, Romagnolo et al 2002 Fig3b Detoxification, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T19H12.2 Aff_T19H12.2 T19H12.2; T19H12.2.1; T19H12.2.2; 5F369; CE13754; WBGene00020588; WP:CE13754 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T19H5.4 Aff_T19H5.4 T19H5.4; 2J776; CE01675; WBGene00011849; WP:CE01675 ViswanathanM et al 2005 S2 sir-2.1 regulated T20B12.6 Aff_T20B12.6 mml-1; T20B12.6; 3I460; CE30186; CE32727; MYC; WBGene00003378; WP:CE30186; WP:CE32727; mio Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit T20B5.1 Aff_T20B5.1 apa-2; apt-4; T20B5.1; T20B5.1.1; T20B5.1.2; CE28680; NM_077171; WBGene00000161; WP:CE28680; XJ961 The apt-4 gene encodes an adaptin: specifically, it encodes an ortholog of the alpha subunit of adaptor protein complex 2 (AP-2). alpha-adaptin McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated T20D4.19 Aff_T20D4.19 T20D4.19; 5D900; CE13814; WBGene00020624; WP:CE13814 T20G5.4 Aff_T20G5.4 T20G5.4; 3L303; CE28844; WBGene00011868; WP:CE28844 Putative membrane protein T20G5.7 Aff_T20G5.7 dod-6; T20G5.7; 3L287; CE00587; NM_066856; WBGene00011869; WP:CE00587 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol T20H4.4 Aff_T20H4.4 adr-2; T20H4.4; T20H4.4.1; T20H4.4.2; 3I322; CE25120; WBGene00000080; WP:CE25120 adr-2 encodes an adenosine deaminase that acts on RNA (ADAR); ADARs are RNA-editing enzymes that deaminate adenosines to create inosines in double-stranded RNA (dsRNA); adr-2 is expressed ubiquitously in early embryos, as well as in the germline of early adults; ADR-2 is required for ADAR activity in vivo, and for normal chemotaxis. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T22A3.8 Aff_C43H8.3 lam-3; T22A3.8; 1L197; CE31067; NM_060374; WBGene00002248; WP:CE31067; lama1/2 lam-3 is orthologous to human LAMININ ALPHA-2 (LAMA2; OMIM:156225), which when mutated leads to merosin-deficient congenital muscular dystrophy. laminin B McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T22B7.4 Aff_T22B7.4 T22B7.4; CE13946; WBGene00020673; WP:CE13946; XG258 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T22C8.4 Aff_T22C8.4 T22C8.4; 2I914; CE36510; WBGene00011925; WP:CE36510 Zinc finger, C2H2 type ViswanathanM et al 2005 S2 sir-2.1 regulated T22F3.4 Aff_T22F3.4 rpl-11.1; T22F3.4; T22F3.4.1; T22F3.4.2; 5E64; CE13968; NM_071607; WBGene00004422; WP:CE13968 rpl-11.1 encodes a large ribosomal subunit L11 protein. 60S ribososmal protein L11 Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, IVb male soma enriched genes, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated T22F7.5 Aff_T22F7.3 T22F7.5; 3B132; CE30305; WBGene00020704; WP:CE30305 T22H2.6 Aff_T22H2.6 T22H2.6; 1M295; CE24004; CE24005; WBGene00011936; WP:CE24004; WP:CE24005 granulin precursor ViswanathanM et al 2005 S2 sir-2.1 regulated T22H6.2 Aff_T22H6.2 T22H6.2; T22H6.2a.1; T22H6.2a.2; CE03697; CE26824; WBGene00011938; WP:CE03697; WP:CE26824; XN405 1-pyroline-5-carboxylate synthetase ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T23B5.1 Aff_T23B5.1 T23B5.1; T23B5.1a.1; T23B5.1a.2; 4N442; CE18281; CE39779; CE39780; WBGene00011939; WP:CE18281; WP:CE39779; WP:CE39780 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T23D8.3 Aff_T23D8.3 T23D8.3; 1K550; CE14052; WBGene00011944; WP:CE14052 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T23G11.4 Aff_T23G11.4 T23G11.4; 1I271; CE14098; WBGene00011969; WP:CE14098 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T23G5.2 Aff_T23G5.2 T23G5.2; T23G5.2a.1; T23G5.2a.2; T23G5.2b.1; T23G5.2b.2; 3K322; CE39782; CE39783; WBGene00011962; WP:CE39782; WP:CE39783 SEC14 (yeast) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated T24A6.17 Aff_T24A6.17 T24A6.17; 5E42; WBGene00020754 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T24B8.1 Aff_T24B8.1 rpl-32; T24B8.1; T24B8.1.1; T24B8.1.2; T24B8.1.3; T24B8.1.4; 2J346; CE03709; NM_063533; WBGene00004446; WP:CE03709 rpl-32 encodes a large ribosomal subunit L32 protein. 60S ribosomal protein L32 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T24B8.3 Aff_T24B8.3 T24B8.3; T24B8.3a.1; T24B8.3a.2; T24B8.3b.1; T24B8.3b.2; 2J350; CE35910; CE35911; WBGene00011977; WP:CE35910; WP:CE35911 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order T24B8.6 Aff_T24B8.6 hlh-3; T24B8.6; 2J377; CE03714; NM_063537; WBGene00001950; WP:CE03714 hlh-3 encodes a basic helix-loop-helix transcription factor homologous to Drosophila Achaete-scute; in vitro, HLH-3 can heterodimerize, and bind an E-box-containing probe, with HLH-2, the C. elegans E/daughterless ortholog with which it is coexpressed in the nuclei of embryonic neuronal precursors. helix-loop-helix protein T24C12.3 Aff_T24C12.3 T24C12.3; CE31247; WBGene00020765; WP:CE31247; XC816 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, herm soma enriched genes T24H7.2 Aff_T24H7.2 T24H7.2; T24H7.2.1; T24H7.2.2; 2G539; CE02884; WBGene00020781; WP:CE02884 T24H7.2 encodes an ortholog of hypoxia-upregulated vertebrate proteins such as human HYOU1; T24H7.2, its C. elegans paralog T14G8.3, and HYOU1 are ER resident hsp70 family molecular chaperone homologs; the grp (glucose regulated protein) 170 family is a collection of related large hsp70 chaperones confined to the ER; members of this family are present in all eukaryotes, participating in a wide range of cellular functions. Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated T25B6.4 Aff_T25B6.4 T25B6.4; CE05014; WBGene00020790; WP:CE05014; XJ633 ViswanathanM et al 2005 S2 sir-2.1 regulated T25D10.4 Aff_T25D10.4 T25D10.4; 2G700; CE02061; WBGene00020801; WP:CE02061 ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination T25G12.8 Aff_T25G12.8 T25G12.8; CE07545; WBGene00020814; WP:CE07545; XR852 Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T26A5.7 Aff_T26A5.7 set-1; T26A5.7; T26A5.7b.1; T26A5.7b.2; 3H540; CE19602; CE34599; WBGene00004781; WP:CE19602; WP:CE34599 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T26A5.8 Aff_T26A5.8 T26A5.8; 3H552; CE00787; WBGene00020823; WP:CE00787 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E T26E3.5 Aff_T26E3.5 T26E3.5; 1N254; CE14192; WBGene00012038; WP:CE14192 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes T26E3.8 Aff_T26E3.8 T26E3.8; 1N250; CE21207; WBGene00012041; WP:CE21207 ViswanathanM et al 2005 S2 daf-16 Resveratrol T26H2.1 Aff_T26H2.1 fbxb-1; T26H2.1; 5T711; CE16487; WBGene00012063; WP:CE16487 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T26H2.3 Aff_T26H2.3 fbxb-2; T26H2.3; 5T706; CE16489; WBGene00012065; WP:CE16489 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T26H2.4 Aff_T26H2.4 fbxb-116; T26H2.4; 5T705; CE16490; WBGene00012066; WP:CE16490 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated T26H2.7 Aff_T26H2.7 T26H2.7; 5T697; CE16492; WBGene00012068; WP:CE16492 Romagnolo et al 2002 Fig3b signaling, ViswanathanM et al 2005 S2 daf-16 Resveratrol T27A10.3 Aff_T27A10.3 ckc-1; T27A10.3; T27A10.3a.1; T27A10.3a.2; CE07553; CE33710; WBGene00000515; WP:CE07553; WP:CE33710; XE193 choline kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T27C4.4 Aff_T27C4.4 egr-1; T27C4.4; 5E189; CE21211; CE21212; CE33330; CE33331; NM_071630; NM_071631; NM_182323; NM_182324; WBGene00001219; WP:CE21211; WP:CE21212; WP:CE33330; WP:CE33331 egr-1 encodes a homolog of human MTA1, part of an ATP-dependent complex with nucleosome remodelling and histone deacetylation activities that may promote tumor metastasis; in conjunction with its paralog egl-27, egr-1 is required for proper organization in all parts of the embryo, and for the embryonic expression of hlh-8. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma T27D12.4 Aff_Y6D1A.D pes-5; T27D12.4; 2M118; CE26472; NM_064126; WBGene00003979; WP:CE26472 pes-5 encodes a novel protein that contains several arginine-rich regions, but no recognizably conserved domains; pes-5 was identified in promoter trapping screens, and as loss of pes-5 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of pes-5 in C. elegans development and/or behavior is not yet known; a pes-5 reporter is expressed in most cells in the early embryo from the 28-cell stage through the end of cellular proliferation, with no expression detected past the comma stage of embryogenesis or in post-embryonic stages; embryonic expression is particularly strong in cells derived from the AB lineage. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T27E4.1 Aff_T27E4.1 T27E4.1; 5J573; CE29357; WBGene00020861; WP:CE29357 Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T27E4.8 Aff_T27E4.2 hsp-16.1; hsp-16; T27E4.8; 5J568; CE14249; NM_072953; WBGene00002015; WP:CE14249 hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein HSP16-1 Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated T27E4.9 Aff_T27E4.3 hsp-16.49; T27E4.9; 5J570; NM_072955; WBGene00002020 hsp-16.49 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.48; HSP-16.49 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein HSP16-48 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated T27F2.1 Aff_T27F2.1 skp-1; T27F2.1; T27F2.1.1; T27F2.1.2; 5M129; CE06519; NM_073549; WBGene00004806; WP:CE06519 Drosophila puff specific protein BX42 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T27F2.3 Aff_T27F2.3 bir-1; T27F2.3; T27F2.3.1; T27F2.3.2; 5M125; CE06521; NM_073548; WBGene00000249; WP:CE06521 bir-1 encodes a homolog of the baculoviral inhibitor-of-apoptosis (IAP) repeat (BIR) proteins (BIRPs) family. Inhibitor of Apoptosis domain. ViswanathanM et al 2005 S2 sir-2.1 regulated T27F7.2 Aff_T27F7.2 T27F7.2; T27F7.2b.1; T27F7.2b.2; 2F277; CE07558; CE27212; CE30457; WBGene00020867; WP:CE07558; WP:CE27212; WP:CE30457 T27F7.2 encodes three proteins by multiple splicing, two of which (T27F7.2A-B) are fully orthologous to vertebrate Shc proteins (e.g., p52/p46SHC and p66SHC); like their orthologs, T27F7.2A-B have a PTB and an SH2 domain in N- to C-terminal order; T27F7.2 is expressed in gastrulating embryos (probably in neural precursors); T27F7.2 might be involved in RAS signal transduction or regulation of apoptosis. ViswanathanM et al 2005 S2 sir-2.1 regulated T28D9.10 Aff_T28D9.10 snr-3; T28D9.10; T28D9.10.1; T28D9.10.2; T28D9.10.3; 2G778; CE02065; NM_062905; WBGene00004916; WP:CE02065 snr-3 encodes an ortholog of human small nuclear ribonucleoprotein Sm D1, a protein that forms part of a heptameric complex required for biogenesis and function of the snRNPs that catalyze mRNA splicing; in combination with the gene that encodes the human Sm D2 ortholog (snr-4), snr-3 affects embryonic viability and nuclear association and localization of P granules in embryos, based on an RNAi assay; affects embryonic and larval viability based on large-scale RNAi assays; snr-3 is expressed in embryos and adult gonads. small nuclear ribonucleoprotein Sm D1 (snRNP core protein D1) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 T28F2.4 Aff_T28F2.4 T28F2.4; 1E200; CE28497; CE37050; WBGene00020902; WP:CE28497; WP:CE37050 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 VH15N14R.1 Aff_VH15N14R.1 VH15N14R.1; 1I356; CE20120; WBGene00012151; WP:CE20120 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated VW06B3R.1 Aff_VW06B3R.1 VW06B3R.1; VW06B3R.1a.1; VW06B3R.1a.2; CE20123; CE26825; WBGene00012158; WP:CE20123; WP:CE26825; XM639 Insulinase (proteinase M16) Golden et al 2004, N2 vs daf-2 different genes at , ViswanathanM et al 2005 S2 sir-2.1 regulated W02B12.2 Aff_W02B12.2 rsp-2; srp-4; W02B12.2; W02B12.2.1; W02B12.2.2; 2L742; CE03762; CeSRp40; NM_064040; WBGene00004699; WBGene00005645; WP:CE03762 pre-mRNA splicing factor like protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated W02B12.3 Aff_W02B12.3 rsp-1; srp-5; W02B12.3; W02B12.3b.1; W02B12.3b.2; 2L745; CE03763; CE32944; CE32945; CeSRp75; NM_064041; NM_182113; NM_182114; WBGene00004698; WP:CE03763; WP:CE32944; WP:CE32945 pre-mRNA splicing factor like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated W02D3.11 Aff_F08B6.D F08B6.D; W02D3.11; 1H330; CE26020; CE31078; WBGene00020936; WP:CE26020; WP:CE31078 W02D3.11 encodes, by alternative splicing, two protein isoforms orthologous to human hnRNP F and hnRNP H proteins, which activate alternative mRNA splicing in neurons; W02D3.11A-B proteins localize to nuclear speckles thought to represent foci of pre-mRNA; with EXC-7 and UNC-75, W02D3.11A-B may act as pre-mRNA splicing factors. W02D3.7 Aff_W02D3.7 lbp-5; W02D3.7; W02D3.7.1; W02D3.7.2; 1H308; CE14430; NM_059527; WBGene00002257; WP:CE14430 lbp-5 encodes a predicted intracellular fatty acid binding protein (iFABP) that is most similar to the vertebrate muscle and heart FABPs; by homology, LBP-5 is predicted to function as an intracellular transporter for small hydrophobic molecules such as lipids and steroid hormones; loss of lbp-5 activity via large-scale RNAi screens indicates that, in C. elegans, LBP-5 is required for movement. fatty acid-binding protein Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated W02D3.9 Aff_W02D3.9 let-76; unc-37; W02D3.9; W02D3.9.1; W02D3.9.2; W02D3.9.3; 1H320; CE14434; ESG; NM_059531; WBGene00006773; WP:CE14434 The unc-37 gene encodes a transducin-like WD-repeat protein homologous to Drosophila GROUCHO that genetically interacts with components of the transcriptional Mediator complex. transducin-like enhancer protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated W02H5.8 Aff_W02H5_1932.J W02H5.8; W02H5.A; W02H5_1932.A; 5D126; CE21240; WBGene00020962; WP:CE21240 McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 W03C9.6 Aff_W03C9.6 W03C9.6; W03C9.6.1; W03C9.6.2; 2M251; CE32948; WBGene00012222; WP:CE32948 W03F9.10 Aff_W03F9.10 W03F9.10; W03F9.10.1; W03F9.10.2; 5A609; CE14540; WBGene00021004; WP:CE14540 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph W03F9.5 Aff_W01A6.J ttb-1; W03F9.5; W03F9.5.1; W03F9.5.2; W03F9.5.3; 5A645; CE27396; CETFIIB; NM_070745; WBGene00006648; WP:CE27396 transcription factor McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated W04A8.4 Aff_W04A8.4 W04A8.4; 1O434; CE16538; WBGene00012239; WP:CE16538 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order W04A8.5 Aff_W04A8.5 W04A8.5; 1O442; CE16539; WBGene00012240; WP:CE16539 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated W04D2.6 Aff_W04D2.6 W04D2.6; 5M983; CE32000; CE32001; WBGene00012245; WP:CE32000; WP:CE32001 RNA recognition motif. (aka RRM, RBD, or RNP domain) Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated W05E10.3 Aff_W05E10.3 ceh-32; W05E10.3; W05E10.3.1; W05E10.3.2; 5M182; CE29364; NM_073557; WBGene00000453; WP:CE29364 ceh-32 encodes a Six/sine oculis-type homeodomain protein most closely related to the Six3/6 subfamily that contains Drosophila OPTIX and human SIX3 (OMIM:603714, which when mutated leads to holoprosencephaly 2); CEH-32 appears to be essential for development and required for proper head morphogenesis; during embryogenesis, CEH-32 is expressed in hypodermal and neuronal precursors, and at later stages, in the descendants of these cells and in gonadal sheath cells; in some hypodermal cells, ceh-32 is a direct transcriptional target of VAB-3, a PAX-6 ortholog sufficient to induce ceh-32 expression in some cell types and able to bind the ceh-32 promoter in vitro. homeobox protein (so subfamily) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol W05H12.2 Aff_W05H12.2 W05H12.2; 1O0; CE14660; WBGene00012290; WP:CE14660 ViswanathanM et al 2005 S2 sir-2.1 regulated W05H9.3 Aff_W05H9.3 W05H9.3; W05H9.3.1; W05H9.3.2; CE05038; WBGene00021050; WP:CE05038; XG873 Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated W06A11.2 Aff_W06A11.2 W06A11.2; 2E350; CE05040; WBGene00021053; WP:CE05040 W06D11.2 Aff_W06D11.2 W06D11.2; CE06553; WBGene00012300; WP:CE06553; XM914 W06D4.4 Aff_T06D10.B W06D4.4; W06D4.4.1; W06D4.4.2; 1J638; CE16546; WBGene00012298; WP:CE16546 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated W06D4.5 Aff_T06D10.C tag-157; W06D4.5; 1J640; CE16547; WBGene00006503; WP:CE16547 PhoX homologous domain, present in p47phox and p40phox. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated W07E6.1 Aff_W07E6.1 W07E6.1; W07E6.1.1; W07E6.1.2; W07E6.1.3; 2A762; CE28259; WBGene00021073; WP:CE28259 nucleolar protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA W08G11.3 Aff_W08G11.3 W08G11.3; 5Q849; CE39423; CE39424; WBGene00012347; WP:CE39423; WP:CE39424 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol W08G11.4 Aff_W08G11.4 W08G11.4; 5Q845; CE39425; WBGene00012348; WP:CE39425 RTS1 PROTEIN (SCS1 PROTEIN) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph W09C2.3 Aff_W09C2.3 mca-1; W09C2.3; 4K392; CE03800; CE25154; CE32951; NM_069308; WBGene00003151; WP:CE03800; WP:CE25154; WP:CE32951 calcium ATPase, isoform c ViswanathanM et al 2005 S2 daf-16 Resveratrol W09C5.1 Aff_W09C5.1 W09C5.1; W09C5.1.1; W09C5.1.2; 1O220; CE20164; WBGene00012351; WP:CE20164 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated W09D10.5 Aff_W09D10.5 W09D10.5; 3L798; CE37798; WBGene00012363; WP:CE37798 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, fem3 enriched genes, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA W09D6.4 Aff_W09D6.4 W09D6.4; 3M169; CE19018; WBGene00012357; WP:CE19018 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 sir-2.1 regulated W10C8.2 Aff_W03D8.4, Aff_W10C8.2 pop-1; sys-2; W10C8.2; 1D392; CE26031; NM_058652; WBGene00004077; WP:CE26031 pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E Y102A5C.12 Aff_Y102A5C.10 Y102A5C.12; 5R422; CE20384; WBGene00013618; WP:CE20384 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y102A5C.22 Aff_Y102A5C.22 srx-54; Y102A5C.22; 5R455; CE36333; NM_074892; WBGene00005945; WP:CE36333 7TM receptor, srx family Romagnolo et al 2002 Fig3b signaling, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y105C5B.28 Aff_Y105C5.ZZ3 gln-3; Y105C5B.28; 4Q934; CE24078; CE39807; NM_070516; WBGene00001604; WP:CE24078; WP:CE39807 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y105E8B.6 Aff_Y105E8A.M Y105E8B.6; 1P255; CE24100; WBGene00013691; WP:CE24100 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated Y106G6D.2 Aff_Y106G6D.2 Y106G6D.2; 1K687; CE19300; WBGene00013699; WP:CE19300 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated Y106G6E.5 Aff_Y106G6E.5 ced-12; mig-16; Y106G6E.5; Y106G6E.5.1; Y106G6E.5.2; 1K800; CE27228; NM_060292; WBGene00000426; WP:CE27228 ced-12 is required both for phagocytotic engulfment of dying (apoptotic) cells, and for normal migrations of healthy cells during development. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y106G6H.4 Aff_Y106G6H.4 Y106G6H.4; 1L14; CE20414; WBGene00013717; WP:CE20414 Y108G3AL.2 Aff_W01A6.G Y108G3AL.2; 5A653; CE26040; WBGene00022434; WP:CE26040 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y111B2A.18 Aff_Y111B2A.M rsp-3; Y111B2A.18; Y111B2A.18.1; Y111B2A.18.2; Y111B2A.18.3; 3N776; CE31089; CeSF2; CeSF2/ASF; NM_067248; WBGene00004700; WP:CE31089 rsp-3 encodes a putative ortholog of human SF2/ASF and member of the SR protein family of nuclear phosphoproteins that are required for constitutive splicing and influence alternative splicing regulation; rsp-3 affects the development of oocytes together with rsr-1, and is required for late embryonic viability; SPK-1 binds directly to and phosphorylates the RS domain of RSP-3 in vitro and the mRNA of rsp-3 is predominantly expressed in the germline. splicing factor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y116A8C.17 Aff_Y116A8A.I Y116A8C.17; 4R968; CE23326; WBGene00013794; WP:CE23326 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y11D7A.12 Aff_Y11D7A.12 Y11D7A.12; 4K28; CE35915; WBGene00012435; WP:CE35915 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y11D7A.13 Aff_Y11D7A.13 Y11D7A.13; 4K37; CE35649; WBGene00012436; WP:CE35649 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y11D7A.3 Aff_Y11D7A.3 Y11D7A.3; 4K5; CE19029; CE39969; WBGene00012428; WP:CE19029; WP:CE39969 ViswanathanM et al 2005 S2 sir-2.1 regulated Y18D10A.19 Aff_Y18D10A.S fkb-2; Y18D10A.19; Y18D10A.19.1; Y18D10A.19.2; 1N511; CE21417; NM_060855; NM_170930; WBGene00001427; WP:CE21417 fkb-2 encodes a peptidylprolyl cis/trans isomerase homologous to the mammalian FK506 immunosuppressant-binding protein 1A (FKBP1A, OMIM:186945, mutations associated with myocardial noncompaction); by homology, FKB-2 could function in a number of processes including protein folding, signal transduction, and regulation of muscle contraction; however, the precise role of FKB-2 in C. elegans development and/or behavior is not yet known,. FKBP-type peptidyl-prolyl cis-trans isomerases Y24D9A.4 Aff_Y24D9A_29.D phi-22; rpl-7A; rpl-8; Y24D9A.4; Y24D9A.4a.1; Y24D9A.4a.2; 4F154; CE27398; CE30401; NM_171316; NM_171904; WBGene00004419; WP:CE27398; WP:CE30401 rpl-8 encodes a large ribosomal subunit L7a protein required in mass RNAi assays for fertility, vulval development, and general health; the rpl-8 transcription unit has one nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-8 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-10, rpl-12) have protein products that are involved in translation. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y32H12A.2 Aff_ZK121.A Y32H12A.2; Y32H12A.2.1; Y32H12A.2.2; Y32H12A_56.A; 3G436; CE24199; WBGene00021311; WP:CE24199 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y32H12A.4 Aff_Y32H12A_57.E Y32H12A.4; Y32H12A.E; 3G460; CE28515; WBGene00021312; WP:CE28515 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y34B4A.7 Aff_Y34B4A_3.B Y34B4A.7; Y34B4A.7.1; Y34B4A.7.2; Y34B4A.B; CE29371; WBGene00021323; WP:CE29371; XF865 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated Y34D9A.4 Aff_Y34D9A_151.B spd-1; Y34D9A.4; 1B504; CE37061; NM_058408; WBGene00004952; WBGene00021330; WP:CE37061 spd-1 encodes a homolog of human PRC1, tobacco MAP-65, and S. cerevisiae Ase1p that is required for embryonic viability due to its requirement for mitotic spindle stability during the late stages of cytokinesis; SPD-1 is also required for fertility, gonad development, locomotion, and vulval development. Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y37A1B.1 Aff_Y37A1B.1 lst-3; Y37A1B.1; 4O841; CE19070; CE33850; WBGene00003085; WP:CE19070; WP:CE33850 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated Y38C1AA.2 Aff_Y38C1_90.A csn-3; Y38C1AA.2; 4A955; CE33861; NM_067477; WBGene00000815; WP:CE33861 csn-3 encodes a subunit ortholog of the eukaryotic COP9/signalosome complex which promotes deneddylation of CUL-3 and is involved in the degradation of the microtubule-severing Katanin-like protein MEI-1 during mitosis; RNA interference of csn-3 results in spindle orientation and cytokinesis defects in the embryo. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y38F2AL.1 Aff_Y38F2A_5743.J Y38F2AL.1; 4D91; CE39822; WBGene00021415; WP:CE39822 Y38F2AL.1 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; Y38F2AL.1 is worm-specific, with obvious homologs only in C. elegans; Y38F2AL.1 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y38H6C.11 Aff_Y38H6C.11 Y38H6C.11; 5U995; CE19105; WBGene00012624; WP:CE19105 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Lund et al 2002 Fig1 aging-regulated genes Y38H6C.7 Aff_Y38H6C.7 Y38H6C.7; 5U985; CE19101; WBGene00012620; WP:CE19101 GuhaThakurta et al 2002 T1 upregu on heat stress Y39A1C.1 Aff_Y39A1C.1 Y39A1C.1; 3L943; CE19146; WBGene00012662; WP:CE19146 Y39A3CL.5 Aff_Y39A3C_85.A clp-4; Y39A3CL.5; Y39A3CL.5b.1; Y39A3CL.5b.2; 3C898; CE33219; CE33220; NM_065059; NM_181914; WBGene00000545; WP:CE33219; WP:CE33220 clp-4 encodes a large calpain subunit that is homologous to Drosophila CalpainB and the mammalian muscle-specific Calpain 3 proteins (OMIM:114240, mutations are associated with limb-girdle muscular dystrophy); by homology, CLP-4 is predicted to function as a nonlysosomal, calcium-dependent, cysteine protease that is involved in intracellular proteolysis and peptidolysis; however, as loss of clp-4 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of CLP-4 in C. elegans development and/or behavior is not yet known. Y39B6A.12 Aff_Y39B6.T Y39B6A.12; Y39B6B.T; Y39B6B.U; 5T594; CE29855; CE38444; WBGene00012674; WP:CE29855; WP:CE38444 Y39B6A.34 Aff_Y39B6.P Y39B6A.34; Y39B6B.P; 5T475; CE29872; WBGene00012693; WP:CE29872 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y39B6A.6 Aff_B0413.A tsp-13; Y39B6A.6; 5T631; CE21670; NM_171602; WBGene00006639; WP:CE21670 Y39G10AR.18 Aff_Y39G10A_233.A Y39G10AR.18; 1C952; CE36735; CE38003; WBGene00021474; WP:CE36735; WP:CE38003 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y40B10B.2 Aff_Y40B10B.A srj-15; Y40B10B.2; Y40B10B.A; 5C440; CE21799; NM_071138; WBGene00005603; WP:CE21799 7TM chemoreceptor, srj family ViswanathanM et al 2005 S2 sir-2.1 regulated Y40B1B.3 Aff_Y40B1B.3 fbxb-66; tag-228; Y40B1B.3; 1O14; CE20237; WBGene00012737; WBGene00044066; WP:CE20237 Y40G12A.1 Aff_F46E10.F ubh-3; Y40G12A.1; 5G986; CE30001; NM_072252; WBGene00006723; WP:CE30001 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y43F4B.2 Aff_Y43F4B.2 Y43F4B.2; 3O384; CE39650; WBGene00012801; WP:CE39650 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y43F8B.2 Aff_Y116F11.OO, Aff_Y43F8B.M Y43F8B.2; 5T994; CE21886; CE21887; WBGene00012813; WP:CE21886; WP:CE21887 ViswanathanM et al 2005 S2 sir-2.1 regulated Y45F10D.9 Aff_Y45F10D.9 sas-6; Y45F10D.9; 4O552; CE16647; NM_070259; WBGene00012888; WP:CE16647 sas-6 encodes a protein that contains a coiled-coil region and a novel PISA (present in SAS-6) motif which is conserved in similar proteins in at least eight other species that contain basal bodies or centrioles; SAS-6 activity, along with that of ZYG-1, SAS-4, SAS-5, and SPD-2, is essential for centriole duplication; SAS-6 functions in a dose-dependent manner and localizes to centriolar cylinders; SAS-6 co-localizes to centrioles with SAS-4 and SAS-5, and is mutually dependent upon SAS-5, with which it interacts physically, for centriolar localization; SAS-6 localization also requires the activity of the ZYG-1 kinase; in addition to the early embryo, SAS-6 is also detected in sperm. Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen Y46B2A.1 Aff_Y46B2_176.C Y46B2A.1; 2B161; CE21951; WBGene00021576; WP:CE21951 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y46H3A.1 Aff_Y32G9B_366.D srt-42; Y46H3A.1; 5C285; CE35804; CE38004; WBGene00021599; WP:CE35804; WP:CE38004 7TM chemoreceptor, srt family ViswanathanM et al 2005 S2 sir-2.1 regulated Y46H3A.2 Aff_Y46H3A.E hsp-16.41; HSP16-41; Y46H3A.2; Y46H3A.E; 5C283; CE22003; NM_071107; WBGene00002018; WP:CE22003 hsp-16.41 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; an hsp-16.41 reporter fusion, expressed broadly but strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.41 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein Golden et al 2004, N2 differentially expressed gen, Link et al 2003 T3 Abeta highly induced, Link et al 2003 T2 Abeta induced, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated Y46H3A.3 Aff_Y46H3A.D hsp-16.2; Y46H3A.3; Y46H3A.D; 5C282; CE22002; NM_071106; WBGene00002016; WP:CE22002 hsp-16.2 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; hsp-16.2 expression, strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; HSP-16.2 has been shown to interact with intracellular human beta amyloid peptide, a primary component of the extracellular plaques found in Alzheimer's disease; HSP-16.2 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein Golden et al 2004, N2 differentially expressed gen, Golden et al 2004, daf-2 differentially expressed , Link et al 2003 T3 Abeta highly induced, Link et al 2003 T2 Abeta induced, Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated Y46H3C.6 Aff_Y46H3C_14.B Y46H3C.6; 5C176; CE35806; WBGene00021606; WP:CE35806 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated Y47D3A.1 Aff_Y47D3A.B Y47D3A.1; 3M228; CE28853; WBGene00012922; WP:CE28853 Y47D3A.28 Aff_Y47D3A.FF Y47D3A.28; 3M415; CE24338; WBGene00012935; WP:CE24338 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y47D3B.10 Aff_Y47D3B.10 dpy-18; phy-1; T28D6.1; Y47D3B.10; Y47D3B.10.1; Y47D3B.10.2; Y47D3B.10.3; Y47D3B.10.4; 3M464; CE20261; NM_067063; WBGene00001077; WP:CE20261 An alpha subunit of prolyl-4-hydroxylase which is a procollagen modifying enzyme required for exoskeleton formation, morphogenesis and maintenance of body shape; it is expressed throughout the hypodermis and certain head and posterior neurons. PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PRECURSOR (EC 1.14.11.2) Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y47G6A.14 Aff_Y47G6A_242.B Y47G6A.14; 1E30; CE34401; WBGene00021640; WP:CE34401 zinc finger protein Reinke et al 2004, list of genes in cluster order, Romagnolo et al 2002 Fig3b Unkown Y47G6A.20 Aff_Y47G6A_245.F rnp-6; Y47G6A.20; 1E108; CE24365; CE24366; CE31375; NM_058775; NM_058776; NM_170843; WBGene00004389; WP:CE24365; WP:CE24366; WP:CE31375 rnp-6 encodes an ortholog of HALF-PINT in D. melanogaster and FBP Interacting Repressor (FIR)/PUF60 in mammals, predicted to be involved in mRNA splicing regulation, mRNA localization, or transcriptional regulation via TFIIH. Y47G6A.7 Aff_Y47G6A_247.J Y47G6A.7; Y47G6A.7a.1; Y47G6A.7a.2; Y47G6A.7b.1; Y47G6A.7b.2; 1E71; CE24373; CE37067; WBGene00021637; WP:CE24373; WP:CE37067 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y47H9B.2 Aff_Y47H9B.1 Y47H9B.2; 1M339; CE34123; WBGene00012946; WP:CE34123 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y47H9C.5 Aff_Y47H9C.5 dnj-27; Y47H9C.5; Y47H9C.5.1; Y47H9C.5.2; 1M477; CE20265; NM_060609; WBGene00001045; WP:CE20265 This gene encodes a protein containing a DnaJ ('J') domain. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C Y48A6B.2 Aff_Y48A6B.2 Y48A6B.2; 3M81; CE19185; WBGene00012963; WP:CE19185 ViswanathanM et al 2005 S2 sir-2.1 regulated Y48B6A.14 Aff_Y48B6A.Q hmg-1.1; Y48B6A.14; Y48B6A.14.1; Y48B6A.14.2; Y48B6A.Q; 2O541; CE29377; NM_064569; WBGene00001971; WP:CE29377 hmg-1.1 encodes a member of the high mobility group (HMG) family of proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated Y48B6A.6 Aff_Y48B6A.G Y48B6A.6; Y48B6A.6a.1; Y48B6A.6a.2; Y48B6A.G; 2O479; CE32970; CE32971; WBGene00012980; WP:CE32970; WP:CE32971 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y48G1C.6 Aff_Y48G1B_55.E Y48G1C.6; 1A558; CE22175; WBGene00021679; WP:CE22175 ViswanathanM et al 2005 S2 sir-2.1 regulated Y48G8AL.8 Aff_Y48G8A_3945.C rpl-17; Y48G8AL.8; Y48G8AL.8a.1; Y48G8AL.8a.2; Y48G8AL.8a.3; Y48G8A_3945.C; 1B631; CE22195; CE30023; NM_170799; NM_171832; WBGene00004429; WP:CE22195; WP:CE30023 rpl-17 encodes a large ribosomal subunit L17 protein; by homology, RPL-17 is predicted to function in protein biosynthesis; in C. elegans, RPL-17 activity is required for embryonic and germline development, as well as normal postembryonic growth rates. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Zhang et al 2002, T1 mec-3 dependent genes Y49E10.15 Aff_Y49E10.O snr-6; Y49E10.15; Y49E10.O; 3N518; CE22230; NM_067219; WBGene00004919; WP:CE22230 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated Y49E10.6 Aff_Y49E10.A his-72; Y49E10.6; Y49E10.6.1; Y49E10.6.2; Y49E10.A; 3N456; CE22223; NM_067207; WBGene00001946; WP:CE22223 his-72 encodes an H3 histone required for embryonic viability. Core histone H2A/H2B/H3/H4 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated Y49F6C.3 Aff_Y49F6C.G bath-9; Y49F6C.3; Y49F6C.G; 2D667; CE22267; WBGene00021725; WP:CE22267 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E Y51B9A.3 Aff_Y51B9A.3 Y51B9A.3; 2J696; CE19213; WBGene00013085; WP:CE19213 Reinke et al 2004, male sperm, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, mixed sperm soma, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, fem3 enriched genes Y53C10A.5 Aff_Y53C10A.B Y53C10A.5; 1M593; CE22373; WBGene00013136; WP:CE22373 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y54E10BR.4 Aff_Y54E10B_159.G Y54E10BR.4; Y54E10BR.F; Y54E10BR.G; Y54E10B_159.F; Y54E10B_159.G; 1D589; CE27481; WBGene00021843; WP:CE27481 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y54E5A.4 Aff_Y105E8A.CC npp-4; Y54E5A.4; Y54E5A.4.1; Y54E5A.4.2; 1P294; CE20315; NM_061151; WBGene00003790; WP:CE20315 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order Y54E5A.5 Aff_Y105E8A.DD Y54E5A.5; Y54E5A.5.1; Y54E5A.5.2; 1P298; CE20316; WBGene00013200; WP:CE20316 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y55B1AR.1 Aff_Y55B1A_120.D lec-6; Y55B1AR.1; Y55B1AR.1.1; Y55B1AR.1.2; 3B218; CE22493; NM_064814; WBGene00002269; WP:CE22493 lec-6 encodes a 'proto' type galectin (beta-galactosyl-binding lectin) containing a single carbohydrate recognition domain; by homology, LEC-6 may play roles in cell adhesion and aggregation, proliferation, or programmed cell death, but as loss of lec-6 activity via large-scale RNAi screens does not result in obvious abnormalities, the precise role of LEC-6 in C. elegans development and/or behavior is not yet known; in vitro, LEC-6 can interact with several types of blood group precursor oligosaccharides and gangliosides. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, IVb male soma enriched genes Y55D5A.1 Aff_Y55D5A_392.F Y55D5A.1; 3E77; CE27294; CE34131; WBGene00021915; WP:CE27294; WP:CE34131 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y55D5A.6 Aff_Y55D5A_391.A Y55D5A.6; 3E132; CE22512; WBGene00021919; WP:CE22512 Golden et al 2004, N2 vs daf-2 different genes at Y55F3AR.2 Aff_Y55F3A_750.A Y55F3AR.2; Y55F3A_750.E; 4B849; CE34418; WBGene00021933; WP:CE34418 Y56A3A.10 Aff_Y56A3A.G fbxb-22; Y56A3A.10; 3M972; CE24465; WBGene00013230; WP:CE24465 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated Y57A10A.13 Aff_Y57A10A.K Y57A10A.13; 2M468; CE25500; WBGene00013256; WP:CE25500 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT Y57A10A.26 Aff_Y57A10A.BB Y57A10A.26; Y57A10A.26.1; Y57A10A.26.2; 2M555; CE22631; WBGene00013266; WP:CE22631 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57A10C.1 Aff_Y57A10C.1 Y57A10C.1; 2M702; CE22632; WBGene00013280; WP:CE22632 Y57G11C.16 Aff_Y57G11C.16 rps-18; Y57G11C.16; Y57G11C.16.1; Y57G11C.16.2; Y57G11C.16.3; Y57G11C.16.4; 4P591; CE14956; NM_070393; WBGene00004487; WP:CE14956 rps-18 encodes a small ribosomal subunit S18 protein. ribosomal protein S13 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57G11C.8 Aff_Y57G11C.8 Y57G11C.8; 4P547; CE39974; WBGene00013306; WP:CE39974 Reinke et al 2004, herm sperm, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57G7A.2 Aff_Y57G7A.2 Y57G7A.2; 2B587; CE19631; WBGene00021966; WP:CE19631 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y59A8B.10 Aff_Y59A8A.G Y59A8B.10; 5S550; CE26206; WBGene00013347; WP:CE26206 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y59A8B.22 Aff_Y59A8A.T Y59A8B.22; Y59A8B.22.1; Y59A8B.22.2; 5S448; CE39869; WBGene00013354; WP:CE39869 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y61A9LA.3 Aff_Y61A9LA_71.B Y61A9LA.3; 5F63; CE27412; CE31122; CE36964; WBGene00022015; WP:CE27412; WP:CE31122; WP:CE36964 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y63D3A.3 Aff_Y63D3A.3 fbxb-101; Y63D3A.3; 1O681; CE25528; WBGene00013404; WP:CE25528 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y63D3A.9 Aff_Y63D3A.9 fbxb-93; Y63D3A.9; 1O672; CE20341; WBGene00013408; WP:CE20341 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y65A5A.1 Aff_Y65A5A.A Y65A5A.1; 4R164; CE22718; WBGene00013418; WP:CE22718 Y69A2AR.29 Aff_Y69A2A_7278.I ngn-1; Y69A2AR.29; 4D392; CE26560; NM_067835; WBGene00003595; WP:CE26560 ngn-1 encodes a member of the neurogenein family that is required for axonal guidance and connectivity of a subset of neurons, and also affects locomotion. Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated Y69H2.6 Aff_Y69H2.I ubc-19; Y69H2.6; Y69H2.I; 5T168; CE22824; NM_075246; WBGene00006714; WP:CE22824 ubc-19 encodes a predicted conjgating enzyme (UBCs/E2s) of the ubiquitin-conjugation system with a potentially low effect on embryonic viability, based on RNAi analysis. ViswanathanM et al 2005 S2 daf-16 Resveratrol Y71A12B.3 Aff_Y71A12B.M Y71A12B.3; 1O485; WBGene00013501 Y71D11A.2 Aff_Y71D11A.D smr-1; Y71D11A.2; 3C233; CE24602; CE34424; WBGene00004891; WP:CE24602; WP:CE34424 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y71F9AL.7 Aff_Y71F9A_294.G Y71F9AL.7; 1D457; CE22861; WBGene00022112; WP:CE22861 ViswanathanM et al 2005 S2 sir-2.1 regulated Y71F9B.10 Aff_Y71F9B_271.A mdt-1.1; sop-3; Y71F9B.10; Y71F9B.10a.1; Y71F9B.10a.2; 1D330; CE28808; CE29912; NM_170837; WBGene00004946; WP:CE28808; WP:CE29912 The sop-3 gene encodes a novel protein that regulates Hox gene expression by modulating Wnt signaling. Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated Y71G12B.6 Aff_Y71G12A_203.E Y71G12B.6; Y71G12B.6.1; Y71G12B.6.2; 1C269; CE29138; WBGene00022146; WP:CE29138 Y71H10A.1 Aff_Y71H10A.1 Y71H10A.1; Y71H10A.1b.1; Y71H10A.1b.2; Y71H10A.1b.3; CE28266; CE37296; WBGene00022199; WP:CE28266; WP:CE37296; XD563 Y71H10A.1 is orthologous to the human gene PHOSPHOFRUCTOKINASE, MUSCLE TYPE (PFKM; OMIM:232800), which when mutated leads to glycogen storage disease VII. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y71H2AM.13 Aff_Y71H2_390.F Y71H2AM.13; 3D824; CE22953; WBGene00022178; WP:CE22953 Y71H2AM.17 Aff_Y71H2_375.B Y71H2AM.17; 3D854; CE39070; WBGene00022182; WP:CE39070 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y71H2B.2 Aff_Y71H2_391.B Y71H2B.2; 3D715; CE24629; WBGene00022192; WP:CE24629 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y74C10AR.1 Aff_Y39G10A_237.B eif-3.I; Y74C10AR.1; Y74C10AR.B; 1D57; CE30325; NM_058587; WBGene00001232; WP:CE30325 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y75B8A.25 Aff_Y75B8A.EE Y75B8A.25; 3N371; CE23036; WBGene00013558; WP:CE23036 ViswanathanM et al 2005 S2 sir-2.1 regulated Y75B8A.7 Aff_Y75B8A.H Y75B8A.7; Y75B8A.I; 3N249; CE23019; WBGene00013544; WP:CE23019 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y76B12C.8 Aff_Y76B12C_67.D Y76B12C.8; Y76B12C.8.1; Y76B12C.8.2; 4C743; CE23063; WBGene00022302; WP:CE23063 Y82E9BL.2 Aff_Y119D3_465.D Y82E9BL.2; 3C442; CE23418; WBGene00022319; WP:CE23418 Y82E9BL.3 Aff_Y119D3_465.E Y82E9BL.3; 3C440; CE23419; WBGene00022320; WP:CE23419 ViswanathanM et al 2005 S2 daf-16 Resveratrol Y82E9BL.5 Aff_Y119D3_465.F Y82E9BL.5; 3C436; CE27547; WBGene00022322; WP:CE27547 Y82E9BR.17 Aff_Y119D3_448.B Y82E9BR.17; 3C536; CE27337; CE34434; WBGene00022349; WP:CE27337; WP:CE34434 Y87G2A.3 Aff_Y87G2A.I Y87G2A.3; 1O128; CE23129; WBGene00013595; WP:CE23129 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y87G2A.6 Aff_Y87G2A.K cyn-15; cyp-15; Y87G2A.6; Y87G2A.6.1; Y87G2A.6.2; 1O158; CE24686; NM_060977; WBGene00000891; WP:CE24686 cyp-15 encodes a little-characterized cyclophilin homolog. cyclophilin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y94H6A.9 Aff_Y94H6A_132.C ubxn-2; Y94H6A.9; Y94H6A_132.B; 4D486; CE27555; CE33955; WBGene00022381; WP:CE27555; WP:CE33955 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y9C9A.13 Aff_Y9C9A_54.B Y9C9A.13; 4F722; CE25647; WBGene00021180; WP:CE25647 ViswanathanM et al 2005 S2 sir-2.1 regulated ZC168.3 Aff_ZC168.3 ZC168.3; 4L498; CE35700; WBGene00013857; WP:CE35700 Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC168.4 Aff_ZC168.4 cyb-1; ZC168.4; ZC168.4.1; ZC168.4.2; ZC168.4.3; ZC168.4.4; 4L501; CE06570; NM_069586; WBGene00000865; WP:CE06570 cyb-1 encodes a cyclin B homolog that appears to be required both for embryogenesis (via maternally encoded CYB-1) and for postembryonic development and fertility (via zygotically encoded CYB-1); removing maternal product in cyb-1(RNAi) embryos causes multiple nuclei, and affected embryos arrest development at an early embryonic stage. cyclin Jiang et al 2001 Fig2 cyclin-genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol ZC204.2 Aff_ZC204.2 ZC204.2; 2B955; CE15086; WBGene00022554; WP:CE15086 homeobox protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC204.9 Aff_ZC204.9 fbxb-20; ZC204.9; 2B938; CE15100; WBGene00022559; WP:CE15100 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated ZC328.4 Aff_ZC328.4 san-1; ZC328.4; 1G985; CE34445; NM_059445; WBGene00004721; WP:CE34445 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC434.5 Aff_ZC434.5 ers-2; qrs-3; ZC434.5; 1K915; CE06580; NM_060310; WBGene00001337; WP:CE06580 ers-2 encodes a predicted mitochondrial glutamyl-tRNA synthetase (GluRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of glutamate to its cognate tRNA and is thus required for protein biosynthesis; ERS-2 contains, at its C-terminus, six tandemly repeated WHEP-TRS domains that have been predicted to function as general RNA-binding domains that may act as cis tRNA-binding cofactors. glutamyl-trna synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph ZC434.6 Aff_ZC434.6 aph-2; ZC434.6; 1K921; CE34446; NM_060311; WBGene00000148; WP:CE34446 aph-2 encodes an ortholog of nicastrin, which associates with presenilin and membrane-bound Notchl in aph-2 mutants, the specification of pi-cells is compromised. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC455.5 Aff_ZC455.5 ugt-4; ZC455.5; 5N274; CE06594; WBGene00013905; WP:CE06594 UDP-glucuronysltransferase ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK1058.6 Aff_ZK1058.6 nit-1; ZK1058.6; 3F11; CE01106; WBGene00014206; WP:CE01106 Nitrilase McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1098.1 Aff_ZK1098.1 ZK1098.1; 3K613; CE03847; WBGene00014218; WP:CE03847 ZK1098.1 encodes a protein, with multiple WW/rsp5/WWP domains and FF domains, required for embryonic viability and for normally high rates of postembryonic growth. WW/rsp5/WWP domain containing proteins (2 domains) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1127.3 Aff_ZK1127.3 ZK1127.3; 2H345; CE28171; WBGene00022850; WP:CE28171 Murphy et al 2003 Fig2 Class2 shorten lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1128.5 Aff_ZK1128.5 ZK1128.5; 3L211; CE01687; WBGene00014231; WP:CE01687 The ZK1128.5 gene encodes a homolog of Swp73/BAF60, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; ZK1128.5 may be involved in asymmetric cell division of the T cells. D15Kz1 protein homolog McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1251.6 Aff_ZK1251.6 msp-76; ZK1251.6; 4K453; NM_069321; WBGene00003463 msp-76 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein (MSP1) Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1251.7 Aff_ZK1251.7 sdz-36; ZK1251.7; 4K455; CE03854; WBGene00014242; WP:CE03854 ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK1307.1 Aff_ZK1307.1 ZK1307.1; ZK1307.1b.1; ZK1307.1b.2; 2J946; CE01690; CE35921; WBGene00014244; WP:CE01690; WP:CE35921 Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK131.4 Aff_ZK131.1 his-10; ZK131.4; 2O114; NM_064492; WBGene00001884 his-10 encodes an H4 histone. histone H4 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK131.6 Aff_ZK131.6 his-12; ZK131.6; 2O112; NM_064490; WBGene00001886 his-12 encodes an H2A histone; his-12 is contained within the histone gene cluster HIS3. histone H2A Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C ZK131.7 Aff_ZK131.2 his-13; ZK131.7; 2O111; NM_064489; WBGene00001887 his-13 encodes an H3 histone; his-13 is contained within the histone gene cluster HIS3. histone H3 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK131.9 Aff_ZK131.5 his-15; ZK131.9; 2O109; NM_064487; WBGene00001889 his-15 encodes an H2B histone. histone H2B McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma ZK1320.10 Aff_ZK1320.10 nlp-11; ZK1320.10; ZK1320.10.1; ZK1320.10.2; 2J978; CE01699; NM_063690; WBGene00003749; WP:CE01699 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK1321.3 Aff_ZK1321.3 aqp-10; ZK1321.3; ZK1321.3.1; ZK1321.3.2; 2K58; CE01710; NM_063704; WBGene00000178; WP:CE01710 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK154.5 Aff_ZK154.5 ZK154.5; CE28177; WBGene00022667; WP:CE28177; XI402 Lund et al 2002 Fig3D Oocyte-en, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK177.6 Aff_ZK177.6 fzy-1; ZK177.6; 2F793; CE26338; NM_062650; WBGene00001511; WP:CE26338 CDC20 Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK185.1 Aff_ZK185.1 ZK185.1; 4F315; CE17310; WBGene00022681; WP:CE17310 ZK20.6 Aff_ZK20.6 nep-1; ZK20.6; ZK20.6.1; ZK20.6.2; 2L946; CE39118; NM_064089; WBGene00013926; WP:CE39118 ZK20.6 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; ZK20.6 is closely paralogous to F18A12.8, and orthologous to CG9761 in Drosophila melanogaster; more generally, ZK20.6 falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes). neprilysin Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK287.5 Aff_ZK287.5 Ce-rbx-1; rbx-1; ZK287.5; ZK287.5.1; ZK287.5.2; 5K170; CE06614; NM_073095; WBGene00004320; WP:CE06614 The rbx-1 gene encodes an ortholog of the mammalian RING box protein RBX1 (or ROC1), which interacts with several cullins and is a subunit of both the von Hippel-Lindau (VHL) tumor suppressor complex and of the SCF ubiquitin-ligase (E3) complex. Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK328.2 Aff_ZK328.2 eft-1; ZK328.2; 3H101; CE05066; NM_065907; WBGene00001166; WP:CE05066 elongation factor 2 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA ZK328.4 Aff_ZK328.4 ZK328.4; 3H96; CE28182; WBGene00022694; WP:CE28182 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen ZK354.11 Aff_ZK354.11 msp-59; ZK354.11; 4G76; NM_068377; WBGene00003452 msp-59 encodes a member of the major sperm protein family. major sperm protein (MSP-59) Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK418.9 Aff_ZK418.9 ZK418.9; ZK418.9b.1; ZK418.9b.2; ZK418.9b.3; ZK418.9b.4; 3I176; CE28190; CE34457; WBGene00022738; WP:CE28190; WP:CE34457 ZK418.9 encodes two proteins by alternative splicing, belonging to an ancient family of single-stranded nucleic acid-binding proteins, that are predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; they are most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK430.5 Aff_ZK430.5 ZK430.5; 2E703; CE05081; WBGene00022741; WP:CE05081 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories ZK512.2 Aff_ZK512.2 ZK512.2; 3K232; CE03821; WBGene00013983; WP:CE03821 RNA helicase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph ZK525.2 Aff_ZK525.2 aqp-11; ZK525.2; 3O765; CE33909; NM_067420; WBGene00000179; WP:CE33909 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK593.6 Aff_ZK593.6 lgg-2; ZK593.6; ZK593.6.1; ZK593.6.2; 4L700; CE06627; NM_069634; WBGene00002981; WP:CE06627 lgg-2 encodes a homolog of the light chain 3 (LC3) subunit of the microtubule-associated proteins 1A and 1B (MAP1A and MAP1B); by homology, LGG-2 is predicted to associate with MAP1A and MAP1B and with microtubules and to perhaps play a role in regulating the microtubule-binding activity of MAP1A and MAP1B; in C. elegans, loss of lgg-2 activity via RNAi does not result in any obvious abnormalities and specifically, does not appear to affect autophagy as required for dauer formation and life-span extension. microtubule-associated protein 1 like ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA ZK632.2 Aff_ZK632.2 ZK632.2; 3K891; CE00419; WBGene00014011; WP:CE00419 Coiled coil protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK632.6 Aff_ZK632.6 cnx-1; ZK632.6; 3K904; CE00423; NM_066775; WBGene00000567; WP:CE00423 cnx-1 encodes the C. elegans ortholog of calnexin, a transmembrane calcium-binding protein that localizes to the endoplasmic reticulum; by homology, CNX-1 is predicted to function as a molecular chaperone that is required for glycoprotein folding and maturation as well as for regulation of intracellular calcium homeostasis; although loss of cnx-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, genetic studies indicate that cnx-1 RNAi can suppress the necrotic-like cell death induced by hyperactive mutations in the MEC-4 and DEG-1 ion channels; thus, in addition to its proposed role in glycoprotein processing, CNX-1 is also required for necrotic-like neuronal death. Calnexin McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK637.4 Aff_ZK637.4 ZK637.4; 3J983; CE00435; WBGene00014024; WP:CE00435 ZK637.7 Aff_ZK637.7 lin-9; ZK637.7; 3J990; CE28194; CE28195; WBGene00002998; WP:CE28194; WP:CE28195 lin-9 encodes two novel proteins that are conserved amongst C. elegans, Drosophila, plants, and vertebrates; lin-9 activity is required redundantly with activity of the synMuv A genes, such as lin-8, for negative regulation of the RTK/Ras-mediated signal transduction pathway that controls vulval development; in addition, lin-9 activity is required non-redundantly for hermaphrodite gonadal sheath cell development (and thus, reproduction), as well as for development of the male reproductive system including the male sensory rays and spicules. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK662.4 Aff_ZK662.4 lin-15B; ZK662.4; CE15381; WBGene00023497; WP:CE15381; XQ349 LIN-15B protein ViswanathanM et al 2005 S2 sir-2.1 regulated ZK792.7 Aff_ZK792.7 ZK792.7; 4M461; CE03828; WBGene00014079; WP:CE03828 Yeast CC1 like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph ZK822.2 Aff_ZK822.2 ZK822.2; 4M688; CE37867; WBGene00014090; WP:CE37867 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK856.7 Aff_ZK856.7 ZK856.7; 5K683; CE06664; WBGene00014108; WP:CE06664 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK856.8 Aff_ZK856.8 ZK856.8; ZK856.8.1; ZK856.8.2; 5K682; CE06665; WBGene00014109; WP:CE06665 EF-hand calcium binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph ZK896.9 Aff_ZK896.9 ZK896.9; 4N619; CE15465; WBGene00014139; WP:CE15465 CMP-sialic acid transporter McCarroll et al 2004 SFig1-4 conserved w/ Drosoph ZK899.2 Aff_ZK899.2 ZK899.2; ZK899.2.1; ZK899.2.2; CE15467; WBGene00014141; WP:CE15467; XK70 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK899.6 Aff_ZK899.6 ZK899.6; CE01123; WBGene00014144; WP:CE01123; XK81 ZK930.1 Aff_ZK930.1 ZK930.1; 2M200; CE06671; WBGene00014151; WP:CE06671 serine/threonine kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK930.6 Aff_ZK930.6 ZK930.6; 2M173; CE06676; WBGene00014156; WP:CE06676 Lund et al 2002 Fig1 aging-regulated genes, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK945.3 Aff_ZK945.3 ZK945.3; 2K391; CE01734; WBGene00014165; WP:CE01734 pumilio-repeat like domain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated