Baugh et al 2003, class ME, 2626 genes Gene list file name: Baugh2003_classME.txt Type of gene identifier: Affymetrix custom chip Description: Baugh et al 2005, Supplymental Dataset, class ME Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations 6R55.1 Aff_6R55.1 6R55.1; CE19652; CE26787; WBGene00007068; WP:CE19652; WP:CE26787; XS331 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 AFF_AC8.J Aff_AC8.J AFF_B0413.D Aff_B0413.D AFF_C06G1.3 Aff_C06G1.3 AFF_C23H3.4 Aff_C23H3.4 AFF_C25A1.6 Aff_C25A1.6 AFF_C25H3.3 Aff_C25H3.3 AFF_C33A11.2 Aff_C33A11.2 AFF_C35D10.1 Aff_C35D10.1 AFF_C45E1.4 Aff_C45E1.4 AFF_C46A5.6 Aff_C46A5.6 AFF_C49A1.8 Aff_C49A1.8 AFF_C50F2.2 Aff_C50F2.2 AFF_E01A2.I Aff_E01A2.I AFF_F07H5.5 Aff_F07H5.5 AFF_F09E5.4 Aff_F09E5.4 AFF_F10G7.10 Aff_F10G7.10 AFF_F15A4.1 Aff_F15A4.1 AFF_F20D12.5 Aff_F20D12.5 AFF_F21H12.1 Aff_F21H12.1 AFF_F22D6.13 Aff_F22D6.13 AFF_F22E5.15 Aff_F22E5.15 AFF_F23A7.6 Aff_F23A7.6 AFF_F23F12.2 Aff_F23F12.2 AFF_F26F4.8 Aff_F26F4.8 AFF_F28B3.6 Aff_F28B3.6 AFF_F32A5.7 Aff_F32A5.7 AFF_F36H2.2 Aff_F36H2.2 AFF_F36H5.7 Aff_F36H5.7 AFF_F39E9.3 Aff_F39E9.3 AFF_F43C11_37.B Aff_F43C11_37.B AFF_F44A2.6 Aff_F44A2.6 AFF_F44B9.8 Aff_F44B9.8 AFF_F45E6.5 Aff_F45E6.5 AFF_F46B6.3 Aff_F46B6.3 AFF_F48A11.6 Aff_F48A11.6 AFF_F49H12.D Aff_F49H12.D AFF_F52C12.2 Aff_F52C12.2 AFF_F52G2.2 Aff_F52G2.2 AFF_F53C3.9 Aff_F53C3.9 AFF_F56A11.1 Aff_F56A11.1 AFF_K02B12.5 Aff_K02B12.5 AFF_K07F5.14 Aff_K07F5.14 AFF_K10C9.2 Aff_K10C9.2 AFF_K11D12.7 Aff_K11D12.7 AFF_R06A4.3 Aff_R06A4.3 AFF_R07E5.12 Aff_R07E5.12 AFF_R07G3.4 Aff_R07G3.4 AFF_R11D1.9 Aff_R11D1.9 AFF_R11G1.2 Aff_R11G1.2 AFF_R144.3 Aff_R144.3 AFF_T01G9.2 Aff_T01G9.2 AFF_T05H4.8 Aff_T05H4.8 AFF_T05H4.9 Aff_T05H4.9 AFF_T08B2.9 Aff_T08B2.9 AFF_T13C5.6 Aff_T13C5.6 AFF_T27E9.7 Aff_T27E9.7 AFF_W10G11.19 Aff_W10G11.19 AFF_Y105E8A.H Aff_Y105E8A.H AFF_Y105E8A.L Aff_Y105E8A.L AFF_Y113G7A.I Aff_Y113G7A.I AFF_Y116A8A.LL Aff_Y116A8A.LL AFF_Y13C8_223.D Aff_Y13C8_223.D AFF_Y25C1A.A Aff_Y25C1A.A AFF_Y32F6A.1 Aff_Y32F6A.1 AFF_Y34D9A_150.D Aff_Y34D9A_150.D AFF_Y37D8A.21 Aff_Y37D8A.21 AFF_Y38A10A.B Aff_Y38A10A.B AFF_Y38A10A.C Aff_Y38A10A.C AFF_Y38F2A_6126.E Aff_Y38F2A_6126.E AFF_Y39B6.R Aff_Y39B6.R AFF_Y39G10A_246.I Aff_Y39G10A_246.I AFF_Y40H7.D Aff_Y40H7.D AFF_Y41D4A_2491.A Aff_Y41D4A_2491.A AFF_Y46B2_176.B Aff_Y46B2_176.B AFF_Y49E10.G Aff_Y49E10.G AFF_Y4C6A.D Aff_Y4C6A.D AFF_Y4C6A.J Aff_Y4C6A.J AFF_Y53F4B.H Aff_Y53F4B.H AFF_Y53G8A_2706.A Aff_Y53G8A_2706.A AFF_Y53G8B_93.E Aff_Y53G8B_93.E AFF_Y54E10A_159.C Aff_Y54E10A_159.C AFF_Y55B1B_119.E Aff_Y55B1B_119.E AFF_Y55F3A_746.B Aff_Y55F3A_746.B AFF_Y59A8A.H Aff_Y59A8A.H AFF_Y59A8A.U Aff_Y59A8A.U AFF_Y63D3A.1 Aff_Y63D3A.1 AFF_Y71F9A_294.B Aff_Y71F9A_294.B AFF_Y71H2_389.E Aff_Y71H2_389.E AFF_Y73F8A.X Aff_Y73F8A.X AFF_Y75B8A.U Aff_Y75B8A.U AFF_Y77E11A_3443.Q Aff_Y77E11A_3443.Q AFF_Y81G3A.A Aff_Y81G3A.A AFF_ZC395.7 Aff_ZC395.7 AFF_ZK105_3.G Aff_ZK105_3.G AFF_ZK1128.1 Aff_ZK1128.1 AFF_ZK1236.5 Aff_ZK1236.5 AFF_ZK688.7 Aff_ZK688.7 AFF_ZK783.4 Aff_ZK783.4 B0001.6 Aff_B0001.6 B0001.6; B0001.6.1; B0001.6.2; B0001.6.3; 4M927; CE31863; WBGene00007091; WP:CE31863 B0001.7 Aff_B0001.7 B0001.7; 4M916; CE05145; WBGene00007092; WP:CE05145 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated B0024.12 Aff_B0024.12 gna-1; B0024.12; 5K800; CE05156; CeGNA1; NM_073253; WBGene00001646; WP:CE05156 gna-1 encodes one of two C. elegans glucosamine 6-phosphate N-acetyltransferases (GNAs); by homology, GNA-1 is predicted to be required for the formation of UDP-N-acetylglucosamine, a substrate in chitin synthesis, Golgi and cytoplasmic glycosylation, and GPI anchoring; as loss of gna-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GNA-1 in C. elegans development and/or behavior is not yet known. Acetyltransferase (GNAT) family McCarroll et al 2004 SFig5 conserved w/ yeast, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 B0025.1 Aff_B0025.1 let-512; vps-34; B0025.1; B0025.1b.1; B0025.1b.2; B0025.1c.1; B0025.1c.2; B0025.1d.1; B0025.1d.2; 1G609; CE24759; CE24760; CE37691; CE37738; CE37739; NM_059340; WBGene00006932; WP:CE24759; WP:CE24760; WP:CE37691; WP:CE37738; WP:CE37739 The vps-34 gene encodes an ortholog of the phosphoinositide 3-kinase VPS34 in S. cerevisiae, a protein that regulates multiple steps in endocytosis, and that is required for growth at normal rates during development. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0035.11 Aff_B0035.11 B0035.11; 4M94; CE05166; WBGene00007110; WP:CE05166 Yeast LEO1 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0035.14 Aff_B0035.14 dnj-1; B0035.14; 4M69; CE05169; NM_069721; WBGene00001019; WP:CE05169 This gene encodes a protein containing a DnaJ ('J') domain. DNAJ protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0035.4 Aff_B0035.4 tag-317; B0035.4; B0035.4.1; B0035.4.2; B0035.4.3; 4M79; 4M81; CE05162; WBGene00007107; WP:CE05162 paramyosin like Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated B0035.7 Aff_F54E12.5 his-47; B0035.7; 4M88; NM_069730; WBGene00001921; his 12 his-47 encodes an H2A histone; by homology, HIS-47 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-47 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV. histone H2A Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated B0035.9 Aff_F54E12.3 his-46; B0035.9; 4M90; NM_069732; WBGene00001920 his-46 encodes an H4 histone. histone H4 ViswanathanM et al 2005 S2 sir-2.1 regulated B0041.2 Aff_B0041.2 B0041.2; B0041.2a.1; B0041.2a.2; 1F227; CE27563; CE29526; CE33546; WBGene00015007; WP:CE27563; WP:CE29526; WP:CE33546 ViswanathanM et al 2005 S2 sir-2.1 regulated B0041.3 Aff_B0041.3 B0041.3; 1F213; CE07668; WBGene00015008; WP:CE07668 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated B0041.4 Aff_B0041.4 rpl-4; B0041.4; B0041.4.1; B0041.4.2; B0041.4.3; 1F214; CE07669; NM_059015; WBGene00004415; WP:CE07669 rpl-4 encodes a large ribosomal subunit L4 protein. ribosomal protein L1 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0041.7 Aff_B0041.7 slr-8; xnp-1; B0041.7; 1F234; CE17314; NM_059022; WBGene00006961; WP:CE17314 xnp-1 encodes an ATP-dependent DNA helicase of the SNF2 family that is orthologous to human XNP/ATR-X, which is associated with a number of X-linked mental retardation syndromes; in C. elegans, xnp-1 activity is required at high temperatures for embryogenesis, somatic gonad development, fertility, and vulval morphogenesis; in addition, animals doubly mutant for xnp-1 and lin-35/Rb, hpl-2/HP1, or nucleosome remodelling and histone deacetylase (NuRD) complex members such as lin-53 and let-418, display larval arrest with growth cessation but continued cell proliferation; xnp-1 is also required, with lin-35/Rb and hpl-2/HP1, for proper regulation of transgene expression; xnp-1 mRNA, detectable in embryos and the germline by in situ hybridization, is expressed at highest levels in embryos with decreasing levels seen in successive larval stages; xnp-1 transcriptional reporter fusions exhibit strong expression beginning at mid-embryogenesis but fading by embryonic morphogenesis; at hatching, expression is observed in all dividing cells including the P lineage, and at later larval stages expression is observed in the vulval precursor cells. helicase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph B0205.6 Aff_B0205.6 B0205.6; 1L315; CE30405; WBGene00015021; WP:CE30405 aminotransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated B0205.7 Aff_B0205.7 kin-3; B0205.7; B0205.7.1; B0205.7.2; 1L311; CE17321; NM_060410; WBGene00002191; WP:CE17321 kin-3 encodes an ortholog of the catalytic subunit of casein kinase II alpha, which in Drosophila and mammals is required for normal circadian rhythms, and which directly phosphorylates the Drosophila PERIOD protein (which itself regulates circadian rhythms); by analogy, KIN-3 might be expected to help regulate heterochronic functions dependent on such proteins as LIN-42. casein kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0205.8 Aff_B0205.8 B0205.8; 1L306; CE17322; WBGene00015022; WP:CE17322 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0213.3 Aff_B0213.3 nlp-28; B0213.3; 5E463; CE16774; NM_071709; WBGene00003766; WP:CE16774 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination B0218.1 Aff_B0218.1 B0218.1; B0218.1a.1; B0218.1a.2; B0218.1a.3; B0218.1a.4; B0218.1a.5; B0218.1b.1; B0218.1b.2; B0218.1b.3; 4I925; CE06684; CE33351; WBGene00015047; WP:CE06684; WP:CE33351 amidase McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0228.7 Aff_B0228.7 B0228.7; 2I48; CE34630; WBGene00015064; WP:CE34630 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0238.10 Aff_B0238.10 B0238.10; 5F753; CE07700; WBGene00015074; WP:CE07700 acyltransfersase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E B0238.11 Aff_B0238.11 B0238.11; B0238.11.1; B0238.11.2; 5F747; CE07701; WBGene00015075; WP:CE07701 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0250.1 Aff_B0250.1 rpl-2; B0250.1; B0250.1.1; B0250.1.2; 5U949; CE18478; NM_075539; WBGene00004413; WP:CE18478 rpl-2 encodes a large ribosomal subunit L8 protein. Ribosomal Proteins L2 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0252.3 Aff_B0252.3 B0252.3; B0252.3c.1; B0252.3c.2; 2H194; CE30586; CE32095; CE34631; WBGene00015088; WP:CE30586; WP:CE32095; WP:CE34631 ViswanathanM et al 2005 S2 sir-2.1 regulated B0252.4 Aff_B0252.4 cyn-10; cyp-10; B0252.4; 2H202; CE02420; CE27567; NM_063015; WBGene00000886; WP:CE02420; WP:CE27567 cyp-10 encodes a divergent cyclophilin isoform that is functional when expressed in E. coli. ViswanathanM et al 2005 S2 sir-2.1 regulated B0261.2 Aff_B0261.2 CE-TOR; let-363; B0261.2; 1F831; CE32559; CE32560; CeTor; NM_059148; NM_059151; WBGene00002583; WP:CE32559; WP:CE32560 let-363 encodes, by alternative splicing, two large (>2600-residue) proteins with C-terminal similarity to phosphatidylinositol kinase (PIK); LET-363 proteins are orthologous to S. cerevisiae Tor1p and Tor2p and human FRAP1 (OMIM:601231, mammalian target of FKBP12-rapamycin); LET-363 proteins are required for progression through the L3 stage of larval development and are thought to generally stimulate translation of most or all mRNAs ('global translation'); LET-363 activity is also necessary for normal development and physiology of the intestine; LET-363 proteins are expressed ubiquitously, including a maternal contribution to the early embryo. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph B0280.10 Aff_B0280.10 B0280.10; 3I222; CE29533; WBGene00015105; WP:CE29533 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0280.3 Aff_B0280.3 B0280.3; B0280.3.1; B0280.3.2; 3I213; CE00733; WBGene00015101; WP:CE00733 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0280.8 Aff_B0280.8 nhr-10; B0280.8; 3I202; CE00815; NM_066153; WBGene00003609; WP:CE00815 nhr-10 encodes a predicted nuclear hormone receptor diverged from nuclear hormone receptors in other phyla; its mRNA is expressed throughout development with possibly lower expression from the L4 larval to adult stages, and the protein is expressed in neuronal processes. retinoic acid ViswanathanM et al 2005 S2 sir-2.1 regulated B0281.5 Aff_B0281.5 B0281.5; 2C588; CE07716; WBGene00015112; WP:CE07716 Jiang et al 2001 Fig1 hermaphrodite-enriched neuro, Jones et al 2001 Non dauer genes P<0.05, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0284.3 Aff_B0284.3 B0284.3; 3F468; CE28525; WBGene00007133; WP:CE28525 B0285.4 Aff_B0285.4 B0285.4; 3F433; CE00643; WBGene00007137; WP:CE00643 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated B0285.9 Aff_B0285.9 ckb-2; B0285.9; 3F459; CE33591; NM_065479; WBGene00000512; WP:CE33591 choline kinase Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig5 genes in let-60 timecour, Romagnolo et al 2002 Fig3b signaling, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 B0303.15 Aff_B0303.15 B0303.15; 3J807; CE00004; WBGene00015133; WP:CE00004 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Ribosomal protein L11 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0303.7 Aff_B0303.7 B0303.7; 3J787; CE36521; WBGene00015128; WP:CE36521 Neutrophil oxidase factor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0304.1 Aff_B0304.1 hlh-1; B0304.1; 2E811; CE02423; CE30067; CE31766; MyoD1; WBGene00001948; WP:CE02423; WP:CE30067; WP:CE31766 hlh-1 encodes a basic helix-loop-helix (bHLH) transcription factor that is the sole C. elegans member of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryonic development for the proper differentiation and function of body wall muscle cells, indicating that unlike its vertebrate counterparts, hlh-1 is not absolutely required for body wall muscle specification; however, ectopic expression of hlh-1 in the embryo is sufficient to convert nearly all embryonic cell types to a muscle-like fate; in regulating body wall muscle cell development in some cell lineages, hlh-1 likely lies downstream of the PAL-1 homeodomain protein that is required for specification of the C and D founder cell fates; HLH-1 is expressed in nuclei and first appears in body wall muscle precursors beginning at the ~80-cell stage of embryogenesis; expression then continues in these cells and their differentiated descendants throughout embryonic, larval, and adult stages of development. helix-loop-helix transcription factor Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Roy et al 2002 S2 positivecontrol L1 muscle, ViswanathanM et al 2005 S2 sir-2.1 regulated B0310.5 Aff_B0310.5 ugt-46; B0310.5; CE03878; WBGene00015141; WP:CE03878; XB146 7TM chemoreceptor, ugt family Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA B0334.4 Aff_B0334.4 B0334.4; 2L787; CE02936; WBGene00007144; WP:CE02936 Yeast hypothetical protein L8167.12 like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0334.5 Aff_B0334.5 B0334.5; 2L789; CE30122; WBGene00007145; WP:CE30122 phytoene synthase precursor ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0334.8 Aff_B0334.8 age-1; daf-23; B0334.8; 2L810; CE23506; NM_064061; WBGene00000090; WP:CE23506 age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects. phosphatidylinositol 3-kinase Jones et al 2001 T2 lifespan and Dauer, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated B0336.1 Aff_B0336.1 wrm-1; B0336.1; B0336.1.1; B0336.1.2; 3G815; CE26743; NM_065835; WBGene00006943; WP:CE26743 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0336.10 Aff_B0336.10 rpl-23; B0336.10; B0336.10.1; B0336.10.2; 3G794; CE00778; NM_065830; WBGene00004435; WP:CE00778 rpl-23 encodes a large ribosomal subunit L23 protein. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0336.2 Aff_B0336.2 arf-1.2; arf-1; B0336.2; B0336.2.1; B0336.2.2; 3G805; ARF/1; CE00696; NM_065834; WBGene00000182; WP:CE00696 arf-1 encodes an ADP-ribosylation factor homolog required in vivo for embryonic development, fertility, locomotion, vulval development, and cuticular synthesis; ARF proteins are N-myristoylated GTPases that regulate membrane traffic and the actin cytoskeleton, and that activate both phospholipase D1 (PLD1) and phosphatidylinositol 4-phosphate 5-kinase. ARF McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA B0336.3 Aff_B0336.3 B0336.3; 3G803; CE29542; WBGene00015143; WP:CE29542 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated B0336.4 Aff_B0336.4 rgs-5; B0336.4; 3G791; CE32098; NM_065828; WBGene00004348; WBGene00015144; WP:CE32098 rgs-5 encodes a regulator of G protein signaling; by homology, RGS-5 is predicted to function as a GTPase-activating protein that binds G protein alpha subunits and negatively regulates heterotrimeric G protein signaling; loss of rgs-5 activity via RNAi or a deletion mutation results in no obvious defects, and likewise, rgs-5 overexpression has no measurable effect on egg-laying behavior, locomotion, or viability; an rgs-5 transcriptional reporter is expressed in head neurons in larvae and adults. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 B0336.6 Aff_B0336.6 B0336.6; B0336.6.1; B0336.6.2; 3G780; CE29545; WBGene00015146; WP:CE29545 B0336.6 encodes an Abl interactor ortholog, with an SH3 domain, required for embryonic development; mammalian Abl interactors are associated with synaptosomes, growth cone particles, and macropinocytic vesicles, and may regulate Rac-dependent cytoskeletal reorganization and Abl kinase activity; B0336.6's orthologs include human SSH3BP1 (ABI1; OMIM:603050, mutated in acute myeloid leukemia), ABI-2 (OMIM:606442), and NESH (OMIM:606363); B0336.6 binds UNC-53 in two-hybrid screens. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0361.2 Aff_F56C9.4 B0361.2; 3I397; CE33549; CE38480; WBGene00015156; WP:CE33549; WP:CE38480 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0361.3 Aff_B0361.3 B0361.3; B0361.3.1; B0361.3.2; 3I373; CE34242; WBGene00015157; WP:CE34242 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0361.6 Aff_B0361.6 B0361.6; 3I366; CE00835; WBGene00015160; WP:CE00835 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA B0379.3 Aff_B0379.3 mut-16; pqn-3; B0379.3; 1K661; CE30474; CE30475; NM_060259; NM_060260; WBGene00003508; WP:CE30474; WP:CE30475 mut-16 encodes a glutamine/asparagine (Q/N)-rich domain-containing protein that lacks obvious homologs outside of other nematode species; MUT-16 activity is required for RNA-mediated interference (RNAi), transgene silencing in germ-line and somatic tissues, and for maintaining low levels of transposon mobilization; MUT-16 is thus predicted to play a role in chromatin organizataion and/or regulation of gene expression. ViswanathanM et al 2005 S2 sir-2.1 regulated B0393.1 Aff_B0393.1 rps-0; B0393.1; B0393.1.1; B0393.1.2; 3F842; CE00854; NM_065577; WBGene00004469; WP:CE00854 rps-0 encodes a small ribosomal subunit SA protein that appears to function as both a ribosomal component and a laminin receptor; by homology, RPS-0 is predicted to play roles in protein biosynthesis and cell adhesion; in C. elegans, RPS-0 activity is required for embryonic and germline development, vulval morphogenesis, and the overall health of the animal. 40S ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0395.3 Aff_B0395.3 B0395.3; B0395.3.1; B0395.3.2; CE02944; WBGene00007175; WP:CE02944; XQ650 B0395.3 is orthologous to the human gene CHOLINE ACETYLTRANSFERASE ISOFORM R (CHAT; OMIM:118490), which when mutated leads to disease. choline O-acetyltransferase Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0403.4 Aff_B0403.4 tag-320; B0403.4; CE03880; WBGene00015168; WP:CE03880; XH686 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. protein disulfide-isomerase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA B0410.2 Aff_B0410.2 vang-1; B0410.2; CE06708; CE27572; NM_076099; NM_076100; WBGene00015171; WP:CE06708; WP:CE27572; XD507 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0412.3 Aff_B0412.3 B0412.3; B0412.3.1; B0412.3.2; 3B425; CE03884; WBGene00015173; WP:CE03884 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0412.4 Aff_B0412.4 rps-29; B0412.4; B0412.4.1; B0412.4.2; 3B413; CE26849; NM_064862; WBGene00004498; WP:CE26849 rps-29 encodes a small ribosomal subunit S29 protein; by homology, RPS-29 is predicted to function in protein biosynthesis; in C. elegans, RPS-29 activity is broadly required for embryonic and germline development, normal body coloration and morphology, normal postembryonic growth rates, and the overall health of the animal. 40S ribosomal protein S29 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0414.5 Aff_B0414.5 cpb-3; B0414.5; 1G366; CE07735; NM_059279; WBGene00000772; WP:CE07735 The cbp-3 gene encodes a cytoplasmic polyadenylation element binding (CPEB) protein homolog. RNA binding protein Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated B0414.7 Aff_B0414.7 mtk-1; B0414.7; 1G372; CE07737; CE27573; NM_059281; NM_059282; WBGene00003472; WP:CE07737; WP:CE27573 protein kinase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated B0414.8 Aff_B0414.8 B0414.8; 1G380; CE30413; CE36910; WBGene00015176; WP:CE30413; WP:CE36910 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0416.4 Aff_B0416.4 B0416.4; CE02434; WBGene00015180; WP:CE02434; XJ899 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0416.5 Aff_B0416.5 B0416.5; B0416.5a.1; B0416.5a.2; CE02435; CE29548; WBGene00015181; WP:CE02435; WP:CE29548; XJ888 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA B0416.6 Aff_B0416.6 gly-13; B0416.6; CE26434; NM_077165; WBGene00001638; WP:CE26434; XJ912 alpha-1,3-mannosyl-glycoprotein beta-1,2-n-acetyglucosaminyltransferase ViswanathanM et al 2005 S2 sir-2.1 regulated B0432.10 Aff_B0432.10 B0432.10; 2A574; CE07748; WBGene00015191; WP:CE07748 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0432.2 Aff_B0432.2 B0432.2; 2A581; CE07740; WBGene00015184; WP:CE07740 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0432.3 Aff_B0432.3 B0432.3; 2A579; CE07741; WBGene00015185; WP:CE07741 ViswanathanM et al 2005 S2 sir-2.1 regulated B0432.4 Aff_B0432.4 B0432.4; 2A577; CE32102; WBGene00015186; WP:CE32102 mitochrondrial 2-oxoglutarate/malate carrier protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated B0454.9 Aff_B0454.9 B0454.9; 2D344; CE07759; WBGene00015200; WP:CE07759 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma B0457.1 Aff_B0457.1 lat-1; B0457.1; 2J197; CE02945; CE32789; CE36086; NM_063493; NM_182149; WBGene00002251; WP:CE02945; WP:CE32789; WP:CE36086 lat-1 encodes a predicted latrophilin that affects embryonic elongation, pharyngeal development, and reproductive organ formation; apically localized in developing epithelia and localized to presynaptic surfaces in neurons. Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated B0464.2 Aff_B0464.2 B0464.2; 3K585; CE20456; WBGene00007184; WP:CE20456 TPR Domain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated B0464.8 Aff_B0464.7 tag-342; B0464.8; 3K559; CE36465; WBGene00007187; WP:CE36465 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0491.7 Aff_B0491.7 B0491.7; 2L641; CE02109; WBGene00007194; WP:CE02109 B0491.7 encodes a putative diphthine synthase orthologous to S. cerevisiae DPH5; DPH5 is an S-adenosylmethionine:EF-2 methyltransferase required for the enzymatic conversion of 3-amino-3-carboxypropyl-histidine to diphthine; DPH5 adds at least the last two of the three methyl groups present in diphthine, and is homologous to bacterial AdoMet:uroporphyrinogen III methyltransferases. diphthine synthase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA B0495.2 Aff_B0495.2 B0495.2; 2H991; CE01761; WBGene00015203; WP:CE01761 CDC2 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated B0495.5 Aff_B0495.5 B0495.5; B0495.5.1; B0495.5.2; 2H986; CE29948; WBGene00015204; WP:CE29948 Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit B0495.6 Aff_B0495.6 B0495.6; 2H988; CE01764; WBGene00015205; WP:CE01764 ViswanathanM et al 2005 S2 sir-2.1 regulated B0495.7 Aff_B0495.7 B0495.7; B0495.7.1; B0495.7.2; 2H992; CE29550; WBGene00015206; WP:CE29550 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA B0507.3 Aff_B0507.3 B0507.3; 5J251; CE07762; CE39664; WBGene00015220; WP:CE07762; WP:CE39664 B0511.1 Aff_B0511.1 fkb-7; B0511.1; 1L245; CE26851; NM_060391; WBGene00001432; WP:CE26851 fkb-7 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506-binding proteins; by homology, FKB-7 could function in a number of different processes including protein folding, signal transduction, and regulation of muscle contraction; however, as loss of fkb-7 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of FKB-7 in C. elegans development and/or behavior is not yet known. Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated B0511.10 Aff_B0511.10 eif-3.E; B0511.10; 1L218; CE17349; NM_060384; WBGene00001228; WP:CE17349 eif-3. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA B0511.12 Aff_B0511.12 B0511.12; 1L232; CE28877; WBGene00015237; WP:CE28877 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated B0511.6 Aff_B0511.6 B0511.6; B0511.6.1; B0511.6.2; 1L203; CE26853; WBGene00015232; WP:CE26853 helicase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0511.9 Aff_B0511.9 B0511.9; 1L216; CE17348; CE26854; WBGene00015235; WP:CE17348; WP:CE26854 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 B0513.2 Aff_B0513.2 B0513.2; 4O649; CE23510; WBGene00007195; WP:CE23510 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen B0513.3 Aff_B0513.3 rpl-29; B0513.3; B0513.3.1; B0513.3.2; 4O647; CE15559; NM_070270; WBGene00004443; WP:CE15559 rpl-29 encodes a large ribosomal subunit L29 protein; by homology, RPL-29 is predicted to function in protein biosynthesis; in C. elegans, loss of rpl-29 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. 60S ribosomal protein L29 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0547.1 Aff_B0547.1 csn-5; B0547.1; B0547.1.1; B0547.1.2; 4G415; CE06722; NM_068440; WBGene00000817; WP:CE06722 csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated B0563.4 Aff_B0563.3 tag-132; B0563.4; CE30843; WBGene00006479; WP:CE30843; XJ777 ViswanathanM et al 2005 S2 sir-2.1 regulated B0564.1 Aff_B0564.1 tin-9.2; B0564.1; 4N865; CE20469; CE37950; NM_070119; WBGene00007201; WBGene00044083; WP:CE20469; WP:CE37950 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C01A2.4 Aff_C01A2.4 C01A2.4; 1N983; CE34247; WBGene00007216; WP:CE34247 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C01B10.5 Aff_C01B10.5 hil-7; C01B10.5; C01B10.5b.1; C01B10.5b.2; H1.Q; 4H411; CE06736; CE26856; CE26857; CE33357; NM_068626; WBGene00001858; WP:CE06736; WP:CE26856; WP:CE26857; WP:CE33357 hil-7 encodes a histone H1.1 isoform that is required in the germline for chromatin silencing (assayed by silencing of transgenic DNA), for proliferation and differentiation, and for fertility; hil-7(RNAi) phenotypes resemble the Mes phenotype resulting from the desilencing of genes required for somatic differentiation in the germline; HIL-7 is required in both the hermaphrodite and the male germlines, and is ubiquitously expressed in all nuclei (somatic and germline). C01B12.8 Aff_C01B12.8 C01B12.8; CE07796; NM_061235; WBGene00015291; WP:CE07796 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories C01B7.1 Aff_C01B7.1 C01B7.1; C01B7.1a.1; C01B7.1a.2; 5J271; CE29553; CE30719; WBGene00015274; WP:CE29553; WP:CE30719 zinc finger protein Murphy et al 2003 Fig2 Class2 shorten lifespan C01C10.3 Aff_C01C10.3 acl-12; C01C10.3; CE02449; NM_076859; WBGene00015295; WP:CE02449; XI58 C01F1.1 Aff_C01F1.1 C01F1.1; 2E595; CE06742; WBGene00015296; WP:CE06742 dna binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C01F1.2 Aff_C01F1.2 C01F1.2; 2E591; CE06743; WBGene00015297; WP:CE06743 C01F1.2 is orthologous to the human gene SCO (CYTOCHROME OXIDASE DEFICIENT, YEAST) HOMOLOG 1 (SCO1; OMIM:603644), which when mutated leads to early-onset hepatic failure; the C01F1.2 protein is predicted to be mitochondrial with 68% accuracy. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C01F6.5 Aff_C01F6.5 aly-1; ref-1; C01F6.5; 4J873; CE02954; NM_069187; WBGene00000120; WP:CE02954 RNA recognition motif. (aka RRM, RBD, or RNP domain) Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Romagnolo et al 2002 Fig3b Metabolism, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C01F6.8 Aff_C01F6.8 icl-1; C01F6.8; 4J860; CE17360; CE30069; ICln; WBGene00002046; WP:CE17360; WP:CE30069 The icl-1 gene encodes, through alternative splicing, two alternative forms (ICL-1A, or 'IClnN1', and ICL-1B, or 'IClnN2'), with distinct electrophysiological properties, of an anion channel homolog. nucleotide-sensitive chloride ion channel Kwon et al 2004 T1 late-induction Ethanol-response, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Transporters, ViswanathanM et al 2005 S2 sir-2.1 regulated C01F6.9 Aff_C01F6.9 C01F6.9; 4J862; CE17361; NX; WBGene00007223; WP:CE17361 The C01F6.9 gene resides in an operon that also contains the genes icl-1 and lpl-1. ViswanathanM et al 2005 S2 sir-2.1 regulated C01G10.8 Aff_C01G10.8 C01G10.8; C01G10.8.1; C01G10.8.2; 5P564; CE07817; WBGene00007235; WP:CE07817 Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C01G12.3 Aff_C01G12.3 C01G12.3; 2O868; CE15573; WBGene00007244; WP:CE15573 Lund et al 2002 Fig1 aging-regulated genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, shared sperm C01G5.6 Aff_C01G5.6 C01G5.6; 4H289; CE23513; WBGene00015308; WP:CE23513 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched C01G6.2 Aff_C01G6.2 C01G6.2; 2J557; CE02958; WBGene00007224; WP:CE02958 Reinke et al 2004, herm sperm, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, IVb male soma enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster D, ViswanathanM et al 2005 S2 sir-2.1 regulated C01G6.3 Aff_C01G6.3 C01G6.3; 2J561; CE37474; WBGene00007225; WP:CE37474 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C01G6.4 Aff_C01G6.4 C01G6.4; 2J562; CE00866; WBGene00007226; WP:CE00866 Zinc finger, C3HC4 type (RING finger) ViswanathanM et al 2005 S2 sir-2.1 regulated C01G6.5 Aff_C01G6.5 C01G6.5; 2J566; CE00867; WBGene00007227; WP:CE00867 Forkhead-associated (FHA) domain Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E C01G6.7 Aff_C01G6.7 C01G6.7; 2J583; CE00869; WBGene00007228; WP:CE00869 4-coumarate-coA ligase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, GO categories, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched C01G6.8 Aff_C01G6.8 cam-1; kin-8; C01G6.8; 2J586; CE24774; CE32563; CE39126; WBGene00000289; WP:CE24774; WP:CE32563; WP:CE39126 The cam-1 gene encodes a receptor tyrosine kinase of the immunoglobulin superfamily that is orthologous to human ROR1 (OMIM:602336) and ROR2 (OMIM:602337, mutation of which leads to type B brachydactyly) and is required for locomotion, cell migration, asymmetric cell division, axon outgrowth, and dauer formation; CAM-1 is broadly expressed during embryogenesis and larval development with expression first appearing at the 200-cell stage of embryogenesis. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C01G8.2 Aff_C01G8.2 cln-3.2; C01G8.2; C01G8.2.1; C01G8.2.2; 1F844; CE07802; NM_059155; WBGene00000540; WP:CE07802 cln-3.2 encodes a predicted transmembrane protein that comprises one of three C. elegans homologs of human CLN3 (OMIM:607042, mutations are associated with Batten disease (also known as juvenile neuronal ceroid lipofuscinosis), a recessively inherited childhood neurodegenerative lysosomal storage disease); loss of cln-3.2 activity via large-scale RNAi screens has been reported to result in either no defects or in embryonic lethality. Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C01H6.7 Aff_C01H6.7 tag-298; C01H6.7; 1H803; CE05190; WBGene00007256; WP:CE05190 Bromodomain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C01H6.9 Aff_C01H6.9 C01H6.9; 1H806; CE07824; WBGene00007258; WP:CE07824 C01H6.9 encodes a homolog of haploid germ cell-specific nuclear protein kinase (haspin) that specifically binds GOA-1 in yeast two-hybrid assays; C01H6.9 is expressed in PHB sensory neurons and PVT interneurons in the tail, several unidentified neurons in the head (with projections to the nose and nerve ring), and intestinal cells, with mainly nuclear localization; C01H6.9 has no obvious function or phenotype in RNAi assays, either alone or with inactivation of a close paralog (F22H10.5). Eukaryotic protein kinase domain Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Romagnolo et al 2002 Fig3b Unkown C02B10.4 Aff_C02B10.4 C02B10.4; C02B10.4.1; C02B10.4.2; 4F857; CE16801; WBGene00015329; WP:CE16801 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C02E11.1 Aff_C02E11.1 C02E11.1; C02E11.1a.1; C02E11.1a.2; 5B508; CE28528; CE32040; WBGene00015344; WP:CE28528; WP:CE32040 Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset C02F12.4 Aff_C02F12.4 tag-52; C02F12.4; CE03899; WBGene00006431; WP:CE03899; XE294 guanine-nucleotide releasing factor of the CDC24 family McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C02F12.8 Aff_C02F12.8 C02F12.8; CE03902; WBGene00015357; WP:CE03902; XE310 Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C02F5.1 Aff_C02F5.1 knl-1; C02F5.1; 3J343; CE02450; NM_066410; WBGene00002231; WP:CE02450 knl-1 encodes a novel acidic protein with a coiled-coil region at its C-terminus; KNL-1 is an essential kinetochore component that is required for proper spindle elongation and chromosome separation, and in the kinetochore assembly pathway, plays a key role in linking the initiation of kinetochore formation with the construction of a functional microtubule-binding interface; in the assembly pathway, KNL-1 functions downstream of the DNA-proximal kinetochore components CeCENP-A/HCP-3 and CeCENP-B/HCP-4 and upstream of the outer kinetochore components HIM-10/Nuf2p, NDC-80/HEC1, CeBUB-1, HCP-1, and CeCLASP2/CLS-2; in expression studies in the one-cell embryo, KNL-1 localizes to kinetochores throughout mitosis. Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C02F5.12 Aff_C02F5.9 C02F5.12; 3J330; CE39127; WBGene00015352; WP:CE39127 C02F5.6 Aff_C02F5.6 C02F5.6; CE00042; CE30417; NM_171212; NM_171213; WBGene00015349; WP:CE00042; WP:CE30417 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C03A7.4 Aff_C03A7.4 pqn-5; C03A7.4; 5F633; CE07862; NM_071981; WBGene00004099; WP:CE07862 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 T1 pqn genes C03B1.12 Aff_C03B1.12 lmp-1; C03B1.12; C03B1.12.1; C03B1.12.2; CE03912; NM_076671; WBGene00003053; WP:CE03912; XG996 lmp-1 encodes a protein with similarity to vertebrate lysosome-associated membrane proteins CD68, and appears to be the only protein in C. elegans that has a GYXX (phi) vertebrate lysosomal targeting sequence at its carboxy terminus; localized to the periphery of a large population of membrane bound organelles (granules) seen throughout the early embryos and restricted to the cells of the intestine during later stages. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C03B1.7 Aff_C03B1.7 C03B1.7; CE03909; WBGene00015378; WP:CE03909; XG963 C03B8.4 Aff_C03B8.4 lin-13; lin-51; C03B8.4; 3I790; CE30419; NM_066277; WBGene00003002; WP:CE30419 Gene Function : lin-13 encodes a large (2248-residue) nuclear protein with multiple zinc fingers of the C2H2 class and a LXCXE retinoblastoma protein-binding motif, that is required for survival through larval development and for negative regulation of vulval fates during postembryonic development. Zinc finger Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order C03C10.1 Aff_C03C10.1 kin-19; C03C10.1; C03C10.1.1; C03C10.1.2; C03C10.1.3; 3F174; CE00872; NM_065417; WBGene00002202; WP:CE00872 kin-19 encodes a serine/threonine kinase orthologous to human casein kinase I, alpha 1 (CSNK1A1, OMIM:600505); KIN-19 appears to be a component of the non-canonical Wnt signaling pathway that regulates endoderm formation in the early embryo; kin-19(RNAi) and mom-2(RNAi) enhance apr-1(RNAi), but not RNAi of each other. casein Kinase I McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C03D6.3 Aff_C03D6.3 cel-1; C03D6.3; 1K243; CE05197; CE32300; NM_060168; WBGene00000466; WP:CE05197; WP:CE32300 cel-1 encodes a mRNA capping enzyme, with a N-terminal region with RNA triphosphatase activity and a C-terminal region containing motifs found in yeast and vaccinia virus capping enzyme guanylytransferases; cel-1 is required for embryonic viability, body morphology, and vulval development. Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset C03D6.4 Aff_C03D6.4 npp-14; C03D6.4; 1K238; CE05198; CeNup214; NM_060167; WBGene00003800; WP:CE05198 npp-14 is orthologous to the human gene NUCLEOPORIN, 214-KD (NUP214; OMIM:114350), which encodes part of the nucleopore complex mediating nucleocytoplasmic transport; NUP214, as a fusion gene with DEK (OMIM:125264), is found in a subset of acute myeloid leukemia. nucleoporin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C03D6.8 Aff_C03D6.8 rpl-24.2; C03D6.8; C03D6.8.1; C03D6.8.2; 1K245; CE05202; NM_060171; WBGene00004437; WP:CE05202 rpl-24.2 encodes a large ribosomal subunit L24 protein paralog; its orthologs include ribosomal protein L30 isologs from mammals and 'Ribosomal Like Protein 24' (Rlp24p) from S. cerevisiae; it therefore appears to actually represent an ancient paralogy between two varieties of eukaryotic L24 protein. ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C03H12.1 Aff_ZK662.1 C03H12.1; CE35380; WBGene00007284; WP:CE35380; XQ313 C03H5.2 Aff_C03H5.2 C03H5.2; 2A681; CE32110; WBGene00015404; WP:CE32110 C03H5.7 Aff_C03H5.7 C03H5.7; 2A673; CE07900; WBGene00015409; WP:CE07900 ViswanathanM et al 2005 S2 daf-16 Resveratrol C04A2.1 Aff_C04A2.1 C04A2.1; 2H139; CE36523; WBGene00015410; WP:CE36523 Shen et al 2005 T1 hif-1 depend hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C04E7.2 Aff_C04E7.2 C04E7.2; CE28816; WBGene00015429; WP:CE28816; XA975 C04F12.10 Aff_C04F12.10 Ce-face-1; fce-1; C04F12.10; 1K288; CE19683; NM_060181; WBGene00001405; WP:CE19683 fce-1 encodes an ortholog of 'farnesylated-proteins converting enzyme 1' (FACE-1), and thus probably enables post-translational processing of proteins (such as LET-60/RAS) carrying a C-terminal CaaX motif; FCE-1 protein probably accounts for the EDTA-sensitive, tosylphenylalanylchloromethane-insensitive component of CaaX-proteolytic activity in membrane extracts from C. elegans, and FCE-1 can cleave a farnesylated peptide in vitro; the S. cerevisiae homolog of FCE-1 (Ste24p) cleaves the precursor of yeast a-factor mating pheromone after its farnesylated cysteine residue, and transgenic FCE-1 rescues a mating defect of mutant yeast lacking both the Ste24p and the Rce1p CaaX-proteases. Zinc-binding metalloprotease domain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C04F12.4 Aff_C04F12.4 rpl-14; C04F12.4; C04F12.4.1; C04F12.4.2; 1K265; CE19677; NM_060175; WBGene00004426; WP:CE19677 rpl-14 encodes a large ribosomal subunit L14 protein. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated C04F12.9 Aff_C04F12.9 C04F12.9; 1K286; CE19682; WBGene00007303; WP:CE19682 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Golden et al 2004, N2 vs daf-2 different genes at , Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C04F5.8 Aff_C04F5.8 C04F5.8; 5F590; CE19672; WBGene00015450; WP:CE19672 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C04F5.9 Aff_C04F5.9 C04F5.9; 5F594; CE19673; WBGene00015451; WP:CE19673 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C04F6.3 Aff_C04F6.3 cht-1; C04F6.3; C04F6.3.1; C04F6.3.2; CE03923; CHT1; NM_076187; WBGene00000503; WP:CE03923; XE16 cht-1 encodes a chitinase orthologous to human chitinase-1 (OMIM:600031, mutations are associated with chitotriosidase deficiency); CHT-1 is predicted to function as an extracellular O-glycosyl hydrolase that hydrolyzes the glycosidic bond between two or more carbohydrates; in C. elegans, CHT-1 may play a role in embryogenesis, and may also be required for cuticle degradation during molting and degradation of chitin-containing pathogens as part of a host defense mechanism. glycosyl hydrolase (family 18) Bishop et al 2004 T1 Upregulated in vhl-1 vs WT, Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C04F6.4 Aff_C04F6.4 unc-78; C04F6.4; C04F6.4b.1; C04F6.4b.2; CE03924; CE33554; NM_076189; WBGene00006810; WP:CE03924; WP:CE33554; XE28 The unc-78 gene encodes a homolog of actin-interacting protein 1 (AIP1) that regulates the ordered assembly of actin and cofilin in myofibrils. McCarroll et al 2004 SFig5 conserved w/ yeast, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C04F6.5 Aff_C04F6.5 dhs-27; C04F6.5; CE37079; NM_076190; WBGene00000990; WP:CE37079; XE32 dhs-27 encodes a short-chain dehydrogenase predicted to be mitochondrial. alcohol/ribitol dehydrogenase ViswanathanM et al 2005 S2 daf-16 Resveratrol C04G2.6 Aff_C04G2.6 dis-3; tag-128; C04G2.6; 4K869; CE05214; NM_069434; WBGene00001001; WP:CE05214 S.pombe mitotic control protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C05C10.2 Aff_C05C10.2 C05C10.2; C05C10.2b.1; C05C10.2b.2; 2K219; CE01466; CE27795; WBGene00007329; WP:CE01466; WP:CE27795 NAM7 protein ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C05C8.2 Aff_C05C8.2 C05C8.2; 5H713; CE07920; WBGene00015461; WP:CE07920 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C05C8.4 Aff_C05C8.4 gei-6; C05C8.4; 5H708; CE07922; NM_072435; WBGene00001563; WP:CE07922 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C05C8.5 Aff_C05C8.5 C05C8.5; 5H714; CE07923; WBGene00015462; WP:CE07923 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C05C8.6 Aff_C05C8.6 C05C8.6; 5H716; CE07924; WBGene00015463; WP:CE07924 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C05D10.1 Aff_C05D10.1 C05D10.1; C05D10.1a.1; C05D10.1a.2; C05D10.1c.1; C05D10.1c.2; C05D10.1c.3; C05D10.1c.4; 3H173; CE24783; CE30420; CE37698; WBGene00015477; WP:CE24783; WP:CE30420; WP:CE37698 ViswanathanM et al 2005 S2 sir-2.1 regulated C05D11.12 Aff_C05D11.12 let-721; C05D11.12; C05D11.12.1; C05D11.12.2; 3H534; CE29662; NM_066014; WBGene00002855; WP:CE29662 The let-721 gene encodes an ortholog of the human gene SIMILAR TO ELECTRON-TRANSFERRING-FLAVOPROTEIN DEHYDROGENASE (ETFDH), which when mutated leads to glutaricaciduria type IIC (OMIM:231675). YAAS McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Oxidation, ViswanathanM et al 2005 S2 sir-2.1 regulated C05D11.2 Aff_C05D11.2 tag-171; vps-16; C05D11.2; C05D11.2.1; C05D11.2.2; 3H525; CE24785; WBGene00006516; WP:CE24785 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Zhang et al 2002, T1 mec-3 dependent genes C05D11.9 Aff_C05D11.9 C05D11.9; 3H518; CE24787; WBGene00015486; WP:CE24787 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated C05D2.10 Aff_C05D2.6 C05D2.10; C05D2.10a.1; C05D2.10a.2; 3G688; CE26861; CE29560; WBGene00015470; WP:CE26861; WP:CE29560 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C05D9.5 Aff_C05D9.5 ife-4; C05D9.5; CE07931; NM_075809; WBGene00002062; WP:CE07931; XB723 The ife-4 gene encodes a member of the Initiation Factor 4E (eIF4E) family. initiation factor 4E (EIF-4E) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C05D9.7 Aff_C05D9.7 C05D9.7; CE07933; WBGene00015474; WP:CE07933; XB736 C05E11.1 Aff_C05E11.1 C05E11.1; CE29561; WBGene00015492; WP:CE29561; XF209 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C05E11.3 Aff_C05E11.3 C05E11.3; CE33029; WBGene00015494; WP:CE33029; XF199 ViswanathanM et al 2005 S2 daf-16 Resveratrol C05G5.2 Aff_C05G5.2 C05G5.2; CE05225; WBGene00007348; WP:CE05225; XP367 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol C05G5.4 Aff_C05G5.4 C05G5.4; CE05227; WBGene00007350; WP:CE05227; XP373 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. succinyl-CoA synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C06A1.1 Aff_C06A1.1 cdc-48.1; phi-31; C06A1.1; 2K850; CE02114; NM_063872; WBGene00007352; WP:CE02114 transitional endoplasmic reticulum ATPase homolog 1 (P97 protein) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C06A1.5 Aff_C06A1.5 C06A1.5; 2K871; CE02117; WBGene00007355; WP:CE02117 DNA directed RNA polymerase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C06A5.11 Aff_C06A5.3 sir-2.4; C06A5.11; 1G567; CE27656; NM_059332; WBGene00004803; WP:CE27656 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C06A5.2 Aff_C06A5.2 C06A5.2; 1G583; CE07949; WBGene00015500; WP:CE07949 Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, shared sperm C06A5.5 Aff_C06A5.5 C06A5.5; 1G558; CE07952; WBGene00015503; WP:CE07952 RNA-binding protein C06A6.2 Aff_C06A6.1 C06A6.2; 4I617; CE31152; CE31153; WBGene00015507; WP:CE31152; WP:CE31153 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C06A6.3 Aff_C06A6.3 C06A6.3; 4I599; CE03941; WBGene00015508; WP:CE03941 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C06A6.5 Aff_C06A6.5 C06A6.5; 4I598; CE27661; WBGene00015510; WP:CE27661 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C06A8.3 Aff_C06A8.3 C06A8.3; 2I81; CE02454; WBGene00015514; WP:CE02454 17k antigen (O. volvulus) ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Zhang et al 2002, T1 mec-3 dependent genes C06A8.5 Aff_C06A8.5 C06A8.5; 2I73; CE02456; WBGene00015515; WP:CE02456 Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated C06B3.4 Aff_C06B3.4 dod-8; stdh-1; C06B3.4; 5O389; CE07961; NM_074048; WBGene00007363; WP:CE07961 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. estradiol 17 beta-dehydrogenase Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated C06E1.1 Aff_C06E1.1 C06E1.1; 3J695; CE00054; WBGene00015518; WP:CE00054 ViswanathanM et al 2005 S2 sir-2.1 regulated C06E2.5 Aff_C06E2.5 C06E2.5; C06E2.5.1; C06E2.5.2; CE30595; WBGene00015529; WP:CE30595; XJ476 C06E7.1 Aff_C06E7.1 C06E7.1; 4G615; CE03957; CE32569; CE33515; CE37186; WBGene00015538; WP:CE03957; WP:CE32569; WP:CE33515; WP:CE37186 S-adenosylmethionine synthetase Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C06E7.4 Aff_C06E7.4 C06E7.4; 4G616; CE29026; WBGene00015541; WP:CE29026 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol C06G1.4 Aff_C06G1.4 ain-1; C06G1.4; C06G1.4.1; C06G1.4.2; CE03967; WBGene00015547; WP:CE03967; XR231 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C06G3.10 Aff_C06G3.10 cgo-2; cogc-2; C06G3.10; 4H802; CE28817; CELDLC; NM_068691; WBGene00000585; WP:CE28817; cog2 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C06G3.11 Aff_C06G3.11 tin-9.1; C06G3.11; C06G3.11b.1; C06G3.11b.2; 4H808; CE07987; CE33518; WBGene00006572; WP:CE07987; WP:CE33518; tim9a; tim9b tin-9 encodes a member of the Tim10/DDP family of zinc finger proteins, a family of proteins typically involved in mitochondrial protein import, and localized to the mitochondrial intermembrane space. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C06G3.5 Aff_C06G3.5 C06G3.5; C06G3.5b.1; C06G3.5b.2; 4H791; CE07981; CE26867; WBGene00015551; WP:CE07981; WP:CE26867 C06G3.5 is orthologous to human ADENOSINE DEAMINASE (ADA; OMIM:102700), which when mutated leads to severe combined immunodeficiency. Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit C06G3.6 Aff_C06G3.6 C06G3.6; 4H783; CE07982; WBGene00015552; WP:CE07982 zinc finger protein ViswanathanM et al 2005 S2 sir-2.1 regulated C06G3.9 Aff_C06G3.9 C06G3.9; C06G3.9.1; C06G3.9.2; 4H798; CE07985; WBGene00015555; WP:CE07985 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen C07A12.3 Aff_C07A12.3 nhr-35; C07A12.3; CE30855; CE38483; NM_076378; WBGene00003628; WP:CE30855; WP:CE38483; XF155 zinc finger protein C07A12.4 Aff_C07A12.4 pdi-2; C07A12.4; C07A12.4a.1; C07A12.4a.2; CE03972; CE31878; NM_076377; NM_182439; WBGene00003963; WP:CE03972; WP:CE31878; XF145 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Kwon et al 2004 T1 late-induction Ethanol-response, Link et al 2003 T2 Abeta repressed, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Roy et al 2002 S3 muscle genes, ViswanathanM et al 2005 S2 UPR genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 C07A12.7 Aff_C07A12.7 C07A12.7; C07A12.7a.1; C07A12.7a.2; C07A12.7c.1; C07A12.7c.2; CE25764; CE27055; CE33557; WBGene00015561; WP:CE25764; WP:CE27055; WP:CE33557; XF138 C07A9.2 Aff_C07A9.2 C07A9.2; C07A9.2.1; C07A9.2.2; 3J784; 3K784; CE00499; WBGene00007400; WP:CE00499 G10 protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories C07D10.5 Aff_C07D10.5 C07D10.5; 2H673; CE36628; WBGene00015569; WP:CE36628 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C07E3.1 Aff_C07E3.1 C07E3.1; 2K638; CE02118; CE23526; WBGene00007412; WP:CE02118; WP:CE23526 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C07E3.6 Aff_C07E3.6 C07E3.6; 2K660; CE35825; WBGene00007417; WP:CE35825 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C07G1.5 Aff_C07G1.5 hgrs-1; pqn-9; C07G1.5; 4I966; CE32574; NM_068974; WBGene00004101; WP:CE32574 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C07G2.3 Aff_C07G2.3 cct-5; C07G2.3; C07G2.3b.1; C07G2.3b.2; C07G2.3b.3; C07G2.3b.4; C07G2.3b.5; C07G2.3b.6; C07G2.3b.7; 3F590; CE02985; CE29569; NM_065514; WBGene00000380; WP:CE02985; WP:CE29569 A homolog of the mouse chaperonin Ccte that affects protein folding; it is expressed at all life stages. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C07G3.9 Aff_C07G3.9 ugt-64; C07G3.9; 5D982; CE08000; WBGene00015577; WP:CE08000 7TM chemoreceptor, ugt family Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories C07H4.2 Aff_C07H4.2 clh-5; C07H4.2; C07H4.2.1; C07H4.2.2; 2J386; CE27360; NM_063539; WBGene00000532; WP:CE27360 The clh-5 gene encodes a chloride channel, whose human homologs include CLC1 and CLCN5; the latter homolog is imvolved in receptor-mediated endocytosis. chloride channel protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C07H6.1 Aff_C07H6.1 lig-4; C07H6.1; 3I613; CE34522; NM_066252; WBGene00002986; WP:CE34522 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C07H6.2 Aff_C07H6.2 C07H6.2; 3I609; CE00756; WBGene00015579; WP:CE00756 ViswanathanM et al 2005 S2 sir-2.1 regulated C07H6.4 Aff_C07H6.4 C07H6.4; 3I591; CE00755; WBGene00015581; WP:CE00755 Probable RNA binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C07H6.5 Aff_C07H6.5 cgh-1; C07H6.5; C07H6.5.1; C07H6.5.2; 3I586; CE00839; NM_066245; WBGene00000479; WP:CE00839 The ortholog of a RNA helicase ste13/ME31B/RCK/p54 that is required for oocyte and sperm function and the prevention of physiological germline-associated apoptosis; it is expressed in the early embryo and germline and localizes to P granules. ATP-dependent RNA helicase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C08A9.6 Aff_C08A9.6 C08A9.6; CE06788; WBGene00015586; WP:CE06788; XR708 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C08A9.7 Aff_C08A9.7 sdz-2; C08A9.7; CE06789; WBGene00015587; WP:CE06789; XR714 ViswanathanM et al 2005 S2 daf-16 Resveratrol C08B11.2 Aff_C08B11.2 hda-2; C08B11.2; 2I312; CE01472; NM_063277; WBGene00001835; WP:CE01472 transcriptional regulatory protein (RPD3) Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C08B11.6 Aff_C08B11.6 C08B11.6; C08B11.6.1; C08B11.6.2; CE30856; WBGene00007434; WP:CE30856 actin McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C08B11.7 Aff_C08B11.7 ubh-4; C08B11.7; 2I328; CE36913; NM_063283; WBGene00006724; WP:CE36913 thiolesterase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C08B11.8 Aff_C08B11.8 C08B11.8; 2I333; CE01478; WBGene00007435; WP:CE01478 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C08B11.9 Aff_C08B11.9 C08B11.9; CE01479; WBGene00007436; WP:CE01479 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C08B6.7 Aff_C08B6.7 C08B6.7; 5K612; CE05244; WBGene00007428; WP:CE05244 59 protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C08F8.1 Aff_C08F8.1 C08F8.1; 4L915; CE05248; WBGene00007443; WP:CE05248 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C08F8.2 Aff_C08F8.2 C08F8.2; C08F8.2b.1; C08F8.2b.2; 4L917; CE05249; CE19689; WBGene00007444; WP:CE05249; WP:CE19689 ATP-dependent RNA helicase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories C08H9.2 Aff_C08H9.2 C08H9.2; 2K178; CE23530; WBGene00007463; WP:CE23530 high-density lipoprotein-binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C08H9.3 Aff_C08H9.3 C08H9.3; 2K174; CE36914; CE37608; WBGene00007464; WP:CE36914; WP:CE37608 glucosyltransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C09B8.5 Aff_C09B8.5 C09B8.5; CE02465; WBGene00015624; WP:CE02465; XG640 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated C09B8.7 Aff_C09B8.7 pak-1; C09B8.7; C09B8.7a.1; C09B8.7a.2; C09B8.7c.1; C09B8.7c.2; C09B8.7e.1; C09B8.7e.2; C09B8.7e.3; CE06792; CE27670; CE33559; CE33561; CePAK; WBGene00003911; WP:CE06792; WP:CE27670; WP:CE33559; WP:CE33561; XG664 pak-1 is orthologous to the human gene P21-ACTIVATED KINASE 3 (PAK3; OMIM:300142), which when mutated leads to nonsyndromic mental retardation. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C09D4.5 Aff_C09D4.5 rpl-19; C09D4.5; C09D4.5.1; C09D4.5.2; C09D4.5.3; 1G54; CE08034; NM_059207; WBGene00004431; WP:CE08034 rpl-19 encodes a large ribosomal subunit L19 protein. 60S ribosomal protein L19 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C09D8.1 Aff_C09D8.1 ptp-3; ptp-3A; ptp-3B; ypp-1; C09D8.1; 2L301; CE30244; CE30245; CE32793; WBGene00004215; WP:CE30244; WP:CE30245; WP:CE32793; YPP/1 ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b signaling, ViswanathanM et al 2005 S2 sir-2.1 regulated C09G4.1 Aff_C09G4.1 LAG1-1; hyl-1; C09G4.1; C09G4.1.1; C09G4.1.2; 4J307; CE27675; NM_069058; WBGene00002043; WP:CE27675 hyl-1 encodes a predicted transmembrane protein that is related to Saccharomyces cerevisiae LAG1 (longevity assurance gene), a protein preferentially expressed in young yeasts; by homology, HYL-1 is predicted to have several possible functions, including regulation of lipid, particularly ceramide, biosynthesis, regulation of lipid transport, and regulation of protein translocation in the endoplasmic reticulum; in C. elegans, however, neither the precise role of HYL-1 in development and/or behavior nor the hyl-1 expression pattern is yet known. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C09G4.4 Aff_C09G4.4 C09G4.4; CE03981; WBGene00044001; WP:CE03981 C09G5.2 Aff_C09G5.2 C09G5.2; 2K992; CE15608; WBGene00007488; WP:CE15608 C09G5.2 encodes an ortholog of S. cerevisiae DPH2/YKL191W and human DPH2L2 (OMIM:603456); C09G5.2 is a putative protein component of diphtamide synthesis; C09G5.2 has no obvious function in mass RNAi assays. Diphthamide biosynthesis protein (diptheria resistance protein) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C C09H10.2 Aff_C09H10.2 rpl-41; C09H10.2; C09H10.2.1; C09H10.2.2; C09H10.2.3; 2L388; CE02131; NM_063974; WBGene00004454; WP:CE02131 rpl-41 encodes a large ribosomal subunit L41 protein; by homology, RPL-41 is predicted to function in protein biosynthesis. 60S ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig3b Protein Synthesis C09H6.1 Aff_C09H6.1 spr-4; C09H6.1; 1I685; CE15609; CE30487; WBGene00005009; WP:CE15609; WP:CE30487 Zinc finger, C2H2 type (11 domains) Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C09H6.3 Aff_C09H6.3 mau-2; C09H6.3; 1I705; CE15611; NM_059827; WBGene00003136; WBGene00007498; WP:CE15611 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C10A4.8 Aff_C10A4.8 C10A4.8; CE35391; WBGene00015669; WP:CE35391; XI30 Zinc finger protein ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C10B5.1 Aff_C10B5.1 C10B5.1; 5J63; CE30722; WBGene00015670; WP:CE30722 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C10C6.1 Aff_C10C6.1 kin-4; C10C6.1; 4M211; CE39132; NM_069760; WBGene00002192; WP:CE39132 serine/threonine kinase Jones et al 2001 Dauer specific genes P<0.05, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset C10F3.5 Aff_C10F3.5 pcm-1; C10F3.5; 5G442; CE08070; NM_072150; WBGene00003954; WP:CE08070 L-isoaspartyl/D-aspartyl methyltransferase ViswanathanM et al 2005 S2 sir-2.1 regulated C10G11.5 Aff_C10G11.5 pnk-1; C10G11.5; C10G11.5c.1; C10G11.5c.2; 1G873; CE29080; CE30488; CE33269; NM_059414; NM_170878; NM_170879; WBGene00004068; WP:CE29080; WP:CE30488; WP:CE33269 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C10G11.7 Aff_C10G11.7 C10G11.7; C10G11.7.1; C10G11.7.2; C10G11.7.3; 1G865; CE08086; WBGene00015687; WP:CE08086 Reinke et al 2004, list of genes in cluster order C11G6.3 Aff_C11G6.3 C11G6.3; CE05257; NM_078257; WBGene00007524; WP:CE05257 PHD-finger. C11H1.4 Aff_C11H1.6 prx-1; C11H1.4; CE30339; NM_077985; WBGene00004191; WP:CE30339; XO943; pex1 prx-1 encodes a predicted peroxin, a subfamily 2 member of the AAA (ATPases Associated with diverse cellular Activities) family that affects growth in one large-scale RNAi screen; expressed in intestinal cells throughout development. peroxisome biosynthesis protein like ViswanathanM et al 2005 S2 sir-2.1 regulated C13B9.3 Aff_C13B9.3 phi-30; C13B9.3; 3H712; CE01778; WBGene00015734; WP:CE01778 C13B9.3 encodes a delta subunit of the coatomer (COPI) complex; in mass RNAi assays, C13B9.3 is required for fertility and general health. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C13C4.4 Aff_C13C4.4 C13C4.4; 5M590; CE20504; WBGene00007548; WP:CE20504 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes C13F10.4 Aff_C13F10.4 C13F10.4; 5H686; CE08145; WBGene00015743; WP:CE08145 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C13F10.6 Aff_C13F10.6 C13F10.6; 5H700; CE08147; WBGene00015745; WP:CE08147 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E C13F10.7 Aff_C13F10.7 C13F10.7; 5H702; CE08148; WBGene00015746; WP:CE08148 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C13G3.3 Aff_C13G3.3 C13G3.3; C13G3.3a.1; C13G3.3a.2; C13G3.3b.1; C13G3.3b.2; 5L508; CE05279; CE20505; WBGene00007554; WP:CE05279; WP:CE20505 proteion phosphatase Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C14A11.6 Aff_C14A11.6 C14A11.6; CE08154; WBGene00015751; WP:CE08154; XD426 C14A4.1 Aff_C14A4.1 tag-242; C14A4.1; C14A4.1.1; C14A4.1.2; CE02138; WBGene00007555; WP:CE02138 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C14A4.3 Aff_C14A4.3 C14A4.3; CE32796; NM_063881; WBGene00007556; WP:CE32796 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Metabolism, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C14A4.4 Aff_C14A4.4 crn-3; C14A4.4; 2K881; CE02145; CE32797; NM_063882; NM_182164; WBGene00000796; WP:CE02145; WP:CE32797 crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C14A4.5 Aff_C14A4.5 crn-5; C14A4.5; 2K883; CE02146; NM_063883; WBGene00000798; WP:CE02146 Prokaryotic ribonuclease PH McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C14B1.1 Aff_C14B1.1 pdi-1; C14B1.1; C14B1.1.1; C14B1.1.2; 3E790; CE00897; NM_065345; WBGene00003962; WP:CE00897 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. protein disulfide isomerase ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 UPR genes, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C14B1.3 Aff_C14B1.3 C14B1.3; 3E793; CE00900; WBGene00007574; WP:CE00900 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C14B1.6 Aff_C14B1.6 C14B1.6; 3E807; CE31415; WBGene00007577; WP:CE31415 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C14B9.2 Aff_C14B9.2 C14B9.2; C14B9.2.1; C14B9.2.2; 3J225; CE30601; WBGene00015752; WP:CE30601 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. erp72 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C14B9.4 Aff_C14B9.4, Aff_K06H7.1 plk-1; C14B9.4; C14B9.4a.1; C14B9.4a.2; 3J193; CE26649; CE30602; WBGene00004042; WP:CE26649; WP:CE30602; plc1 plk-1 encodes a serine/threonine polo-like kinase homologous to Drosophila polo and Saccharomyces cerevisiae CDC5; PLK-1 is required for meiotic nuclear envelope breakdown, polar body formation and extrusion, and proper chromosome segregation during meiosis, and additionally, may play a role in germline development; PLK-1 is proposed to phosphorylate REC-8, a meiotic-specific cohesin, thus promoting REC-8 degradation and subsequent separation of sister chromatids; PLK-1 is localized diffusely in the cytoplasm of mature oocytes, but during meiosis I becomes associated with pre-metaphase chromatin and then at anaphase with chromatin and the area between dividing chromatin; in embryos, PLK-1 localizes to centrosomes, metaphase chromatin, and during telophase, to the area between dividing chromatin. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C14B9.7 Aff_C14B9.7 rpl-21; C14B9.7; C14B9.7.1; C14B9.7.2; C14B9.7.3; 3J218; CE00078; NM_066373; WBGene00004433; WP:CE00078 rpl-21 encodes a large ribosomal subunit L21 protein; by homology, RPL-21 is predicted to function in protein biosynthesis; in C. elegans, RPL-21 activity is required for embryonic and germline development. Ribosomal protein L21 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C14B9.8 Aff_C14B9.8 C14B9.8; 3J230; CE38273; WBGene00015754; WP:CE38273 C14B9.8 is orthologous to the human gene PHOSPHORYLASE KINASE, LIVER, ALPHA-2 SUBUNIT (PHKA2; OMIM:306000), which when mutated leads to liver glycogenosis. Phosphorylase kinase Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit C14C10.4 Aff_C14C10.4 C14C10.4; C14C10.4.1; C14C10.4.2; 5N74; CE05283; WBGene00007587; WP:CE05283 Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C14C10.5 Aff_C14C10.5 C14C10.5; 5N87; CE05284; WBGene00007588; WP:CE05284 Human mRNA (KIAA0077) product like Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C14C11.7 Aff_C14C11.7 C14C11.7; 5G146; CE06826; WBGene00015769; WP:CE06826 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C14F5.1 Aff_C14F5.1 BCL-2; C14F5.1; CE01780; CE29172; WBGene00015776; WP:CE01780; WP:CE29172; XI573 C15F1.4 Aff_C15F1.E ppp-1; C15F1.4; C15F1.E; 2H256; CE23548; NM_063027; WBGene00004090; WP:CE23548 translation initiation factor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C15F1.6 Aff_C15F1.C art-1; C15F1.6; 2H262; CE20509; NM_063029; WBGene00000198; WP:CE20509 a protein similar to synaptic glycoprotein SC2 from mammals. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C15H11.4 Aff_C15H11.4 dhs-22; C15H11.4; 5O900; CE08181; NM_074169; WBGene00000985; WP:CE08181 dhs-22 encodes a short-chain dehydrogenase predicted to be mitochondrial. dehydrogenase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C15H11.8 Aff_C15H11.8 C15H11.8; 5O904; CE08185; WBGene00007616; WP:CE08185 DNA-directed RNA polymerase I like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C15H11.9 Aff_C15H11.9 C15H11.9; C15H11.9.1; C15H11.9.2; 5O906; CE08186; WBGene00007617; WP:CE08186 Human HA0609 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C15H9.1 Aff_C15H9.1 nnt-1; C15H9.1; CE08176; NM_076627; WBGene00003778; WP:CE08176; XG745 nnt-1 encodes a proton-pumping nicotinamide nucleotide transhydrogenase predicted to be mitochondrial. NAD(P) transhydrogenase, mitochondrial Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C15H9.6 Aff_C15H9.6 hsp-3; C15H9.6; C15H9.6.1; C15H9.6.2; C15H9.6.3; CE08177; NM_076618; WBGene00002007; WP:CE08177; XG708 hsp-3 encodes a heat shock response 70 (hsp70) protein orthologous to human glucose regulated protein 78 (grp78/BiP, OMIM:138120); HSP-3 likely functions as a molecular chaperone, and is expressed constitutively (expression is not heat inducible) throughout development with greatest abundance during the L1 larval stage; HSP-3 contains a long hydrophobic amino terminus and a carboxyl terminal KDEL sequence suggesting that it may be retained in the endoplasmic reticulum. heat shock protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig2a heat shock C16A3.1 Aff_C16A3.1 C16A3.1; C16A3.1a.1; C16A3.1a.2; 3H483; CE27688; CE30605; CE30606; WBGene00015806; WP:CE27688; WP:CE30605; WP:CE30606 C16A3.1 is orthologous to the human gene SMARCAL1 (SMARCAL1; OMIM:606622), which when mutated leads to disease Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C16A3.2 Aff_C16A3.2 C16A3.2; 3H479; CE08188; WBGene00015807; WP:CE08188 protein-tyrosine phosphatase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C16A3.3 Aff_C16A3.3 C16A3.3; 3H477; CE27690; NM_065997; WBGene00015808; WP:CE27690 Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C16A3.4 Aff_C16A3.4 C16A3.4; 3H473; CE04004; WBGene00015809; WP:CE04004 Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C16A3.5 Aff_C16A3.5 C16A3.5; C16A3.5.1; C16A3.5.2; 3H471; CE04005; WBGene00015810; WP:CE04005 NADH-ubiquinone oxidoreductase B22 Lund et al 2002 Fig1 aging-regulated genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C16A3.6 Aff_C16A3.6 C16A3.6; 3H469; CE04006; WBGene00015811; WP:CE04006 Lund et al 2002 Fig1 aging-regulated genes, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C16A3.9 Aff_C16A3.9 rps-13; C16A3.9; C16A3.9.1; C16A3.9.2; 3H464; CE04009; NM_065992; WBGene00004482; WP:CE04009 rps-13 encodes a small ribosomal subunit S13 protein; by homology, RPS-13 is predicted to function in protein biosynthesis; in C. elegans, RPS-13 activity is required for embryonic and germline development. 40S ribosomal protein S13 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C16B8.4 Aff_C16B8.4 C16B8.4; CE30248; WBGene00015824; WP:CE30248; XE590 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B C16C10.10 Aff_C16C10.10 tag-73; C16C10.10; 3F243; CE01490; WBGene00006448; WP:CE01490 Glyoxalase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C16C10.11 Aff_C16C10.11 C16C10.11; C16C10.11.1; C16C10.11.2; 3F241; CE01491; WBGene00007630; WP:CE01491 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C16C10.5 Aff_C16C10.5 C16C10.5; 3F260; CE01496; WBGene00007626; WP:CE01496 Glutaredoxin, Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan C16C10.6 Aff_C16C10.6 C16C10.6; 3F258; CE01497; WBGene00007627; WP:CE01497 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated C16C10.7 Aff_C16C10.7 rnf-5; C16C10.7; 3F254; CE01498; NM_065429; WBGene00004381; WP:CE01498 This gene encodes a homolog of mammalian RNF5, a C3HC4 (RING-finger) zinc-finger protein. Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C16D9.6 Aff_C16D9.6 C16D9.6; 5I726; CE35240; WBGene00015861; WP:CE35240 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C16H3.3 Aff_C16H3.4 C16H3.3; CE08237; CE27697; WBGene00015868; WP:CE08237; WP:CE27697; XS216 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol C17C3.1 Aff_C17C3.1 C17C3.1; 2F863; CE27070; CE27071; CE27072; CE27073; CE39676; WBGene00015887; WP:CE27070; WP:CE27071; WP:CE27072; WP:CE27073; WP:CE39676 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C17E4.2 Aff_C17E4.2 C17E4.2; 1J991; CE08251; WBGene00007642; WP:CE08251 myosin heavy chain like Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E C17E4.6 Aff_C17E4.8 C17E4.6; 1K7; CE25780; WBGene00007645; WP:CE25780 YL-1 protein like Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C17G1.4 Aff_C17G1.4 C17G1.4; CE08283; CE37318; WBGene00007651; WP:CE08283; WP:CE37318; XK546 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories C17G10.1 Aff_C17G10.1 C17G10.1; C17G10.1.1; C17G10.1.2; 2F887; CE01785; WBGene00015915; WP:CE01785 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C17G10.2 Aff_C17G10.2 C17G10.2; 2F885; CE29583; WBGene00015916; WP:CE29583 TPR domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C17G10.8 Aff_C17G10.8 dhs-6; C17G10.8; CED6.1; 2F906; CE02490; WBGene00000970; WP:CE02490 The dhs-6 locus is predicted to encode four transcripts derived from alternative splicing and alternative transcriptional initiation sites; the longest transcript is predicted to encode a member of the eukaryotic translation initiation factor family within its amino-terminal end, and is a member of both the SCP-2 sterol transfer family and short-chain dehydrogenase-reductase families within its carboxyl-terminal end; DHS-6 is predicted to be mitochondrial. Alcohol dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C18A11.5 Aff_C18A11.5 xol-1; C18A11.5; CE24807; CE35708; CE35709; WBGene00006962; WP:CE24807; WP:CE35708; WP:CE35709; XI661 ViswanathanM et al 2005 S2 sir-2.1 regulated C18A3.2 Aff_C18A3.2 C18A3.2; 2G9; CE27707; WBGene00015940; WP:CE27707 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C18A3.5 Aff_C18A3.5 C18A3.5; C18A3.5e.1; C18A3.5e.2; C18A3.5f.1; C18A3.5f.2; C18A3.5f.3; C18A3.5f.4; C18A3.5f.5; 2G2; CE27708; CE27709; CE27710; CE32130; CE32131; WBGene00015943; WP:CE27708; WP:CE27709; WP:CE27710; WP:CE32130; WP:CE32131 RNA binding protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma C18A3.8 Aff_C18A3.8 hlh-14; C18A3.8; 2G28; CE36629; NM_062730; WBGene00001958; WP:CE36629 hlh-14 encodes a basic helix-loop-helix (bHLH) transcription factor that is one of five C. elegans Achaete-Scute family homologs; HLH-14 activity is required generally for normal egg-laying, movement, body morphology, and larval development; more specifically, HLH-14 is required for proper neuronal development, particularly for regulation of the asymmetric cell division that gives rise to the PVQ/HSN/PHB neuroblasts and for normal differentiation of these neuroblast descendants, including their cell division patterns, migrations, and neurotransmitter expression; in specifying neuronal cell fates, genetic evidence suggests that hlh-14 acts together with hlh-2, which encodes the C. elegans E/Daughterless ortholog; HLH-14 is expresed exclusively in the embryo and detected in the left and right PVQ/HSN/PHB neuroblasts and their descendants, as well as in other cells identified, tentatively, as anterior neuroblasts and posterior neuroblasts such as Caapa. helix-loop-helix transcription factor C18B12.6 Aff_C18B12.6 C18B12.6; CE32590; WBGene00007668; WP:CE32590; XP624 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C18B2.4 Aff_C18B2.4 C18B2.4; CE04043; WBGene00015955; WP:CE04043; XE224 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C18C4.10 Aff_C18C4.10 klc-2; C18C4.10; C18C4.10b.1; C18C4.10b.2; C18C4.10b.3; C18C4.10b.4; C18C4.10b.5; C18C4.10c.1; C18C4.10c.2; C18C4.10d.1; C18C4.10d.2; 5G58; CE27362; CE32802; CE32803; CE36917; WBGene00002215; WP:CE27362; WP:CE32802; WP:CE32803; WP:CE36917 klc-2 encodes a kinesin light chain and was identified as a protein that interacts with UNC-16 by the yeast two-hybrid system, this association suggests that KLC-2 may be involved in the regulation of synaptic vesicle localization by the UNC-16-JNK signaling complex. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C18D11.4 Aff_C18D11.4 rsp-8; C18D11.4; C18D11.4.1; C18D11.4.2; 3M919; CE18515; NM_067132; WBGene00004705; WP:CE18515 RNA recognition motif. (aka RRM, RBD, or RNP domain) ViswanathanM et al 2005 S2 sir-2.1 regulated C18D4.6 Aff_C18D4.6 C18D4.6; 5S16; CE32310; CE32311; CE36469; WBGene00007675; WP:CE32310; WP:CE32311; WP:CE36469 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C18E3.2 Aff_C18E3.2 C18E3.2; C18E3.2.1; C18E3.2.2; 1E779; CE30249; WBGene00015971; WP:CE30249 The C18E3.2 gene encodes a homolog of Swp73/BAF60, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; C18E3.2 is probably required during mitosis of the T cells for asymmetric cell division. Jiang et al 2001 Fig1 hermaphrodite-enriched TF, Lund et al 2002 Fig3D Oocyte-en, ViswanathanM et al 2005 S2 sir-2.1 regulated C18E9.3 Aff_C18E9.3 pqn-14; C18E9.3; C18E9.3c.1; C18E9.3c.2; C18E9.3c.3; 2J258; CE20519; CE32804; CE38277; NM_063508; NM_063509; WBGene00004105; WP:CE20519; WP:CE32804; WP:CE38277 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen C18E9.6 Aff_C18E9.6 C18E9.6; 2J262; CE05298; WBGene00007686; WP:CE05298 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C18H7.3 Aff_C18H7.3 col-102; C18H7.3; 4B353; CE17428; NM_067556; WBGene00000676; WP:CE17428 cuticular collagen Romagnolo et al 2002 Fig3b Cell Structure, ViswanathanM et al 2005 S2 sir-2.1 regulated C18H9.3 Aff_C18H9.3 C18H9.3; 2G981; CE01803; WBGene00016002; WP:CE01803 C23G10.3 Aff_C23G10.3 rps-3; C23G10.3; C23G10.3.1; C23G10.3.2; 3H297; CE01810; NM_065948; WBGene00004472; WP:CE01810 rps-3 encodes a small ribosomal subunit S3 protein that contains a KH RNA-binding domain and by homology,is predicted to function in protein biosynthesis; in C. elegans, RPS-3 activity is required for embryonic and germline development, as well as the overall health of the animal. Ribosomal protein S3 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C23G10.8 Aff_C23G10.8 C23G10.8; C23G10.9; 3H292; CE25784; WBGene00016015; WP:CE25784 S. pombe adenylyl cyclase-associated protein (weak) Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen C23H3.1 Aff_C23H3.1 cog-4; egl-26; egl-48; C23H3.1; 2A377; CE08320; NM_061251; WBGene00001193; WP:CE08320 egl-26 encodes a novel protein that contains an H-box/NC domain that is highly conserved with CBP01801 in C. briggsae and is required for embryonic and larval viability, egg-laying, fertility, and affects the connection of the uterus to the vulva; required in the primary vulval lineage for vulF morphogenesis and is expressed in many cells, but is expressed near the vulva and uterus only during the L4 larval stage. Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C23H3.5 Aff_C23H3.5 C23H3.5; C23H3.5.1; C23H3.5.2; 2A339; CE08324; WBGene00016021; WP:CE08324 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C24D10.4 Aff_C24D10.4 C24D10.4; 4F925; CE16876; WBGene00016055; WP:CE16876 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C24D10.6 Aff_C24D10.6 C24D10.6; 4F924; CE16878; WBGene00016057; WP:CE16878 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C24F3.2 Aff_C24F3.2 C24F3.2; 4K987; CE18519; WBGene00007697; WP:CE18519 Dual specificity phosphatase, catalytic domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C24F3.4 Aff_C24F3.4 C24F3.4; 4K980; CE18521; WBGene00007698; WP:CE18521 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 C24G6.4 Aff_C24G6.4 Csr-1; nhr-279; nhr-47; C24G6.4; C24G6.4.1; C24G6.4.2; 5F989; CE27727; NM_072054; WBGene00003637; WP:CE27727 nhr-47 is predicted to encode a nuclear hormone receptor (NHR); gene expression of nhr-47 appears to be induced upon exposure of worm cultures to estradiol. zinc finger protein ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C24H12.4 Aff_C24H12.4 C24H12.4; 2A705; CE27728; CE29675; WBGene00016073; WP:CE27728; WP:CE29675 helicase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen C25A1.1 Aff_C25A1.1 C25A1.1; 1K739; CE08366; WBGene00007705; WP:CE08366 Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C25A1.10 Aff_C25A1.10 dao-5; C25A1.10; 1K764; CE08376; CE38279; WBGene00000931; WP:CE08376; WP:CE38279 dao-5 encodes a predicted nucleolar phosphoprotein related to Saccharomyces cerevisiae SRP40 and the vertebrate Nopp140 proteins that may play a role in rRNA gene transcription and nucleolar structural organization; dao-5 expression is negatively regulated by the DAF-2/insulin-like receptor and positively regulated by the DAF-16/fork-head transcription factor, suggesting that dao-5 may be involved in life-span determination; dao-5 is strongly expressed in dauer larvae. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes C25A1.13 Aff_C25A1.13 C25A1.13; 1K769; CE08379; WBGene00007712; WP:CE08379 NADH-ubiquinone oxidoreductase B8 subunit McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C25A1.3 Aff_C25A1.3 tag-72; C25A1.3; 1K736; CE36918; WBGene00006447; WP:CE36918 Yeast ABD1 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, GO categories, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C25A1.4 Aff_C25A1.4 C25A1.4; C25A1.4.1; C25A1.4.2; 1K746; CE08369; WBGene00007706; WP:CE08369 RNA binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C25A1.5 Aff_C25A1.5 C25A1.5; 1K755; CE08370; WBGene00007707; WP:CE08370 Yeast hypothetical 44.9 KD protein like Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C25B8.4 Aff_C25B8.4 C25B8.4; CE27087; CE34259; CE34260; WBGene00016088; WP:CE27087; WP:CE34259; WP:CE34260; XH236 asialoglycoprotein receptor ReichertK et al 2005 T3 xenobiotic downregulated, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C25D7.3 Aff_C25D7.3 dpy-29; sdc-3; C25D7.3; 5P520; CE08389; NM_074302; WBGene00004747; WP:CE08389 sdc-3 encodes a protein that contains two mutationally separable domains: a zinc finger motif required for dosage compensation and a myosin- like putative ATP- binding region required for her-1 regulation of sex determination; SDC-3 activates dosage compensation by directing the dosage compensation protein complex to the hermaphrodite X chromosomes, and is functionally redundant with SDC-2 with respect to dosage compensation; SDC-1, SDC-2, and SDC-3 proteins form a complex. Zinc finger, C2H2 type Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C25F6.1 Aff_C25F6.1 C25F6.1; CE02494; WBGene00016102; WP:CE02494; XG107 ViswanathanM et al 2005 S2 sir-2.1 regulated C25F6.2 Aff_C25F6.2 dlg-1; C25F6.2; C25F6.2a.1; C25F6.2a.2; C25F6.2b.1; C25F6.2b.2; CE34261; CE36524; NM_076527; WBGene00001006; WP:CE34261; WP:CE36524; XG103 dlg-1 encodes a MAGUK protein, orthologous to Drosophila disks large, that is physically located to adherens junctions in all epithelia and that is genetically required for organization of the embryonic gut epithelium into an coherent tube. Lund et al 2002 Fig1 aging-regulated genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C25F6.3 Aff_C25F6.3 C25F6.3; CE38489; WBGene00016103; WP:CE38489; XG89 The C25F6.3 gene encodes an ortholog of the human gene DIHYDROPYRIMIDINE DEHYDROGENASE (DPYD), which when mutated leads to thymine-uraciluria (OMIM:274270). McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C25G4.10 Aff_C25G4.10 C25G4.10; 4N233; CE28206; WBGene00007736; WP:CE28206 fibronectin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C25G4.2 Aff_C25G4.2 C25G4.2; 4N208; CE05303; WBGene00007730; WP:CE05303 dihydrofolate reductase like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C25G4.5 Aff_C25G4.5 dpy-26; C25G4.5; 4N212; CE08398; NM_069977; WBGene00001085; WP:CE08398 SDC-1, SDC-2, and SDC-3 proteins form a complex (detectable by coimmunoprecipitation); these three proteins, in turn, colocalize with DPY-26, DPY-27, and MIX-1 proteins both on a transgenic her-1(+) array and on the X chromosome. Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen C26B2.1 Aff_C26B2.1 C26B2.1; 4I784; CE04087; WBGene00016124; WP:CE04087 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol C26C6.1 Aff_C26C6.1 tag-185; C26C6.1; C26C6.1b.1; C26C6.1b.2; C26C6.1b.3; 1I79; CE30254; CE38280; WBGene00007042; WBGene00007738; WP:CE30254; WP:CE38280 HMG (high mobility group) box, Bromodomain (5 domains), Zinc finger, C2H2 type McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C26D10.2 Aff_C26D10.2 hel-1; C26D10.2; C26D10.2b.1; C26D10.2b.2; 2I618; CE03025; CE32593; WBGene00001840; WP:CE03025; WP:CE32593; hel translation initiation factor eIF-4A McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C26E6.4 Aff_C26E6.4 phi-14; rpb-2; C26E6.4; 3G33; CE01162; NM_065646; WBGene00016140; WP:CE01162 DNA-directed RNA polymerase II McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C26E6.6 Aff_C26E6.6 C26E6.6; C26E6.6.1; C26E6.6.2; 3G25; CE39477; WBGene00016142; WP:CE39477 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Ribosomal protein L3 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C26E6.8 Aff_C26E6.8 ula-1; C26E6.8; C26E6.8.1; C26E6.8.2; 3G8; CE29678; NM_065636; WBGene00006735; WP:CE29678 The ula-1 gene encodes a component of the enzyme that activates NED-8, which in turn is a ubiquitin-like protein whose conjugating enzyme is UBC-12. Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C26F1.4 Aff_C26F1.4 rps-30; C26F1.4; C26F1.4.1; C26F1.4.2; C26F1.4.3; 5I257; CE06878; NM_072606; WBGene00004499; WP:CE06878 rps-30 encodes two proteins, a small ribosomal subunit S30 protein and ubiquitin, which is cleaved from the ribosomal protein posttranslationally; by homology, S30 is predicted to function in protein biosynthesis and ubiquitin in protein degradation; in C. elegans, loss of rps-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. ribosomal protein/ubiquitin-like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C26F1.9 Aff_C26F1.9 rpl-39; C26F1.9; C26F1.9.1; C26F1.9.2; 5I256; CE06883; NM_072605; WBGene00004453; WP:CE06883 rpl-39 encodes a large ribosomal subunit L39 protein. ribosomal protein L39 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C27A12.2 Aff_C27A12.2 C27A12.2; 1G621; CE08411; WBGene00016154; WP:CE08411 zinc finger protein Jiang et al 2001 Fig1 hermaphrodite-enriched TF, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C27A12.6 Aff_C27A12.6 C27A12.6; 1G630; CE08415; WBGene00016156; WP:CE08415 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C27A12.7 Aff_C27A12.7 C27A12.7; C27A12.7a.1; C27A12.7a.2; C27A12.7b.1; C27A12.7b.2; C27A12.7b.3; C27A12.7b.4; C27A12.7b.5; C27A12.7b.6; 1G634; CE08416; CE32810; WBGene00016157; WP:CE08416; WP:CE32810 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C27A12.9 Aff_C27A12.9 C27A12.9; 1G638; CE36272; WBGene00016159; WP:CE36272 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 C27A2.2 Aff_C27A2.2 rpl-22; C27A2.2; C27A2.2a.1; C27A2.2a.2; 2F347; CE04102; CE29188; NM_062531; NM_062532; WBGene00004434; WP:CE04102; WP:CE29188 rpl-22 encodes a large ribosomal subunit L22 protein; by homology, RPL-22 is predicted to function in protein biosynthesis; in C. elegans, RPL-22 activity is broadly required for embryonic and germline development, as well as normal body coloration, morphology, and postembryonic growth rates. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C27A2.6 Aff_C27A2.6 dsh-2; C27A2.6; 2F370; CE27097; NM_062536; WBGene00001102; WP:CE27097 dsh-2 encodes a protein containing a DIX domain, a DEP domain, and a PDZ domain that is required for embryonic viability and functions in Wnt pathway signaling between the embryonic blastomeres P2 and EMS with respect to endoderm specification and to orient the division axis of the EMS cell; expressed from the four-cell embryo stage, and is primarily associated with membranes. Jiang et al 2001 Fig4 Wnt signaling genes, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C27B7.4 Aff_C27B7.4 C27B7.4; 4J665; CE17477; WBGene00007761; WP:CE17477 DNA repair protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol C27C12.1 Aff_C27C12.1 C27C12.1; CE05318; WBGene00007771; WP:CE05318; XP470 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C27D11.1 Aff_C27D11.1 eif-3.A; egl-45; C27D11.1; 3I914; CE00543; NM_066297; WBGene00001209; WP:CE00543 egl-45 encodes a homolog of eukaryotic translation initiation factor 3, subunit 10, that affects development of the HSNs that affect egg laying. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C27F2.5 Aff_C27F2.5 C27F2.5; C27F2.5.1; C27F2.5.2; 3G50; CE26875; WBGene00016167; WP:CE26875 S. cerevisiae Snf8p McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C27F2.8 Aff_C27F2.8 C27F2.8; 3G82; CE39000; WBGene00016170; WP:CE39000 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C27H5.3 Aff_C27H5.3 C27H5.3; C27H5.3.1; C27H5.3.2; C27H5.3.3; 2H445; CE27099; WBGene00016173; WP:CE27099 Probable RNA binding protein ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C27H6.2 Aff_C27H6.2 ruvb-1; C27H6.2; 5K460; CE08426; NM_073166; WBGene00007784; WP:CE08426 Yeast hypothetical 50.5 KD protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C27H6.4 Aff_C27H6.4 C27H6.4; 5K464; CE08428; CE31322; WBGene00007786; WP:CE08428; WP:CE31322 C27H6.8 Aff_K08H10.8 C27H6.8; C27H6.8.1; C27H6.8.2; K08H10.8; 5K466; CE18880; WBGene00007787; WP:CE18880 Yeast hypothetical protein YEY6 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C28H8.1 Aff_C28H8.1 C28H8.1; 3H17; CE01820; WBGene00016192; WP:CE01820 C28H8.1 is orthologous to the human gene BCL7A (OMIM:601406), which when mutated leads to high-grade B-cell non-Hodgkin lymphoma. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, IVb male soma enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C28H8.12 Aff_C28H8.12 dnc-2; C28H8.12; 3H14; CE01823; NM_065885; WBGene00001018; WP:CE01823 dnc-2 encodes a member of the dynamitin family that affects spindle alignment in polarized cells in early embryos, nuclear movement, spindle morphology, chromosome segregation, and pronuclear migration. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C28H8.3 Aff_C28H8.3 C28H8.3; C28H8.3.1; C28H8.3.2; C28H8.3.3; 3H3; CE29195; WBGene00016194; WP:CE29195 ViswanathanM et al 2005 S2 sir-2.1 regulated C28H8.9 Aff_C28H8.9 C28H8.9; 3G994; CE06896; CE32813; WBGene00016200; WP:CE06896; WP:CE32813 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen C29A12.3 Aff_C29A12.3 lig-1; C29A12.3; 5L295; CE37480; CE37481; NM_171537; NM_171538; WBGene00002985; WP:CE37480; WP:CE37481 lig-1 is orthologous to the human gene LIM HOMEOBOX PROTEIN 3 ISOFORM B (LIG1; OMIM:600577), which when mutated leads to disease. Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C29E4.2 Aff_C29E4.2 tag-261; C29E4.2; 3J33; CE30620; WBGene00016202; WP:CE30620 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C29E6.1 Aff_C29E6.1 let-653; C29E6.1; C29E6.1b.1; C29E6.1b.2; 4M655; CE05332; CE37323; WBGene00002827; WP:CE05332; WP:CE37323 let-653 encodes a mucin-like protein similar to the highly glycosylated mucins secreted by the apical surface of epithelia and believed to provide a protective barrier to exposed cellular surfaces; LET-653 is required for viability, locomotion, and for maintaining the tubular epithelial structure of the excretory cell canals. LET-653 mucin like protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT C29F3.1 Aff_C29F3.1 ech-1; C29F3.1; 5P838; CE08435; NM_074409; WBGene00001150; WP:CE08435 long-chain enoyl-CoA hydratase C29F4.1 Aff_C29F4.1 col-125; C29F4.1; C29F4.1.1; C29F4.1.2; 4L991; CE03038; NM_069706; WBGene00000699; WP:CE03038 collagen Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C29F7.3 Aff_C29F7.3 C29F7.3; CE08444; WBGene00007812; WP:CE08444; XO38 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. uridylate kinase McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C29F7.4 Aff_C29F7.4 fkh-3; C29F7.4; CE08445; NM_077836; WBGene00001435; WP:CE08445; XO40 fork head domain protein Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C29F7.5 Aff_C29F7.5 fkh-4; tag-39; C29F7.5; CE08446; NM_077837; WBGene00001436; WP:CE08446; XO46 fkh-4 encodes a member of the forkhead domain transcription factor family. fork head domain protein Jiang et al 2001 Fig1 hermaphrodite-enriched TF, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C29F9.7 Aff_C29F9.7 pat-4; C29F9.7; C29F9.7.1; C29F9.7.2; 3A708; CE19706; NM_064738; WBGene00003931; WP:CE19706 The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes. integrin-linked kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Roy et al 2002 S2 positivecontrol L1 muscle C29H12.2 Aff_C29H12.2 C29H12.2; C29H12.2.1; C29H12.2.2; C29H12.2.3; 2G415; CE02516; WBGene00016235; WP:CE02516 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C30B5.2 Aff_C30B5.2 C30B5.2; 2G487; CE31889; CE31890; WBGene00016244; WP:CE31889; WP:CE31890 ViswanathanM et al 2005 S2 sir-2.1 regulated C30C11.1 Aff_C30C11.1 C30C11.1; 3J539; CE00100; WBGene00016249; WP:CE00100 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C30F12.5 Aff_C30F12.5 C30F12.5; 1H568; CE16885; WBGene00016264; WP:CE16885 Jones et al 2001 Dauer specific genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S4 Climbing, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S4 genes pass two-wayANOVA P0 C30G4.6 Aff_C30G4.6 C30G4.6; CE39902; WBGene00016271; WP:CE39902; XR688 ViswanathanM et al 2005 S2 daf-16 Resveratrol C30H6.8 Aff_C30H6.8 C30H6.8; 4S327; CE15652; WBGene00007825; WP:CE15652 Thioredoxins ViswanathanM et al 2005 S2 sir-2.1 regulated C30H7.2 Aff_C30H7.2 C30H7.2; C30H7.2a.1; C30H7.2a.2; C30H7.2a.3; C30H7.2a.4; 1F986; CE27807; CE39231; WBGene00016278; WP:CE27807; WP:CE39231 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C31B8.8 Aff_C31B8.8 C31B8.8; 5D384; CE26674; WBGene00016283; WP:CE26674 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C31C9.2 Aff_C31C9.2 C31C9.2; C31C9.2.1; C31C9.2.2; 2N928; CE08497; WBGene00007836; WP:CE08497 C31C9.2 is orthologous to the human gene PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH; OMIM:606879), which when mutated leads to phosphoglycerate dehydrogenase deficiency. D-3-Phosphoglycerate dehydrogenase Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C31E10.5 Aff_C31E10.5 C31E10.5; CE08505; WBGene00007846; WP:CE08505; XO610 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C31E10.7 Aff_C31E10.7 C31E10.7; C31E10.7.1; C31E10.7.2; CE37487; WBGene00007848; WP:CE37487; XO621 C31E10.7 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:10230) (CYB5; OMIM:250790), which when mutated leads to disease. cytochrome b5 Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C31G12.1 Aff_C31G12.1 C31G12.1; 5S657; CE15660; WBGene00007850; WP:CE15660 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C31H5.4 Aff_C31H5.4 C31H5.4; C31H5.4.1; C31H5.4.2; 1J618; CE17484; NM_060029; WBGene00007855; WP:CE17484 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C32B5.10 Aff_C32B5.10 C32B5.10; 2B238; CE08518; WBGene00016303; WP:CE08518 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C32C4.2 Aff_C32C4.2 aqp-6; C32C4.2; 5L131; CE05345; NM_073326; WBGene00000174; WP:CE05345 MIP protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C32D5.5 Aff_C32D5.5 tag-337; C32D5.5; C32D5.5.1; C32D5.5.2; 2G620; CE01845; WBGene00016313; WP:CE01845 Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C32D5.8 Aff_C32D5.8 C32D5.8; C32D5.8a.1; C32D5.8a.2; 2G632; CE01848; CE37326; WBGene00016316; WP:CE01848; WP:CE37326 Thioredoxin Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C32D5.9 Aff_C32D5.9 lgg-1; C32D5.9; C32D5.9.1; C32D5.9.2; 2G636; CE01849; NM_062876; WBGene00002980; WP:CE01849 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C32E8.2 Aff_C32E8.2 rpl-13; C32E8.2; C32E8.2a.1; C32E8.2a.2; C32E8.2a.3; C32E8.2b.1; C32E8.2b.2; 1E357; CE08526; CE33562; WBGene00004425; WP:CE08526; WP:CE33562 rpl-13 encodes a large ribosomal subunit L13 protein. ViswanathanM et al 2005 S2 sir-2.1 regulated C32E8.4 Aff_C32E8.4 C32E8.4; 1E353; CE29692; WBGene00016322; WP:CE29692 Lund et al 2002 Fig1 aging-regulated genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 sir-2.1 regulated C32F10.2 Aff_C32F10.2 lin-35; C32F10.2; 1G391; CE24823; NM_059285; WBGene00003020; WP:CE24823 lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, lin-35 activity is required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C32F10.6 Aff_C32F10.6 crf-2; nhr-2; C32F10.6; C32F10.7; 1G396; CE39002; NM_059288; WBGene00003601; WP:CE39002 nhr-2 encodes a member of the nuclear hormone receptor family that is required for embryonic viability and morphogenesis; expressed during embryogenesis. nuclear homone receptor Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C33A12.3 Aff_C33A12.3 C33A12.3; 4K278; CE05349; WBGene00007882; WP:CE05349 Kwon et al 2004 T1 late-induction Ethanol-response, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C33D12.1 Aff_C33D12.1 ceh-31; C33D12.1; CE39566; NM_076124; WBGene00000452; WP:CE39566; XD686 ceh-31 encodes a protein containing a homeobox domain. homeobox protein ViswanathanM et al 2005 S2 sir-2.1 regulated C33E10.2 Aff_C33E10.2 fbxa-120; C33E10.2; CE17491; WBGene00016346; WP:CE17491; XR913 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C33F10.4 Aff_C33F10.3 C33F10.4; 2F87; CE02530; CE02531; CE27103; WBGene00016353; WP:CE02530; WP:CE02531; WP:CE27103 McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C33G3.3 Aff_C33G3.3 C33G3.3; CE08559; WBGene00007903; WP:CE08559; XO686 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C33G3.4 Aff_C33G3.4 C33G3.4; CE08560; WBGene00007904; WP:CE08560; XO693 C33G3.4 is orthologous to the human gene BETA-MANNOSIDASE (MANBA; OMIM:248510), which when mutated leads to disease. beta-mannosidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C33H5.12 Aff_C33H5.12 rsp-6; srp-1; C33H5.12; C33H5.12a.1; C33H5.12a.2; C33H5.12b.1; C33H5.12b.2; 4I554; CE04155; CE29697; CE29698; CeSRp20; NM_171383; NM_171384; NM_171385; WBGene00004703; WP:CE04155; WP:CE29697; WP:CE29698 RNA binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C33H5.15 Aff_C33H5.15 sgo-1; C33H5.15; 4I560; CE34732; NM_068889; WBGene00016381; WP:CE34732 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C33H5.7 Aff_C33H5.7 C33H5.7; 4I539; CE04150; WBGene00016374; WP:CE04150 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C33H5.8 Aff_C33H5.8 C33H5.8; 4I542; CE04151; WBGene00016375; WP:CE04151 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C33H5.9 Aff_C33H5.9 C33H5.9; 4I544; CE04152; WBGene00016376; WP:CE04152 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C34B2.10 Aff_C34B2.10 phi-56; C34B2.10; C34B2.10.1; C34B2.10.2; 1L258; CE16898; WBGene00016395; WP:CE16898 ViswanathanM et al 2005 S2 sir-2.1 regulated C34B2.2 Aff_C34B2.2 kbp-5; C34B2.2; 1L263; CE16890; NM_060399; WBGene00016387; WP:CE16890 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C34B2.3 Aff_C34B2.3 C34B2.3; 1L251; CE34266; WBGene00016388; WP:CE34266 protein kinase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, GO categories, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 sir-2.1 regulated C34B7.2 Aff_C34B7.2 C34B7.2; 1I917; CE32316; WBGene00007912; WP:CE32316 Yeast hypothetical protein YNOD like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated C34C12.4 Aff_C34C12.4 C34C12.4; C34C12.4.1; C34C12.4.2; 3E558; CE31434; WBGene00007923; WP:CE31434 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, fem3 enriched genes C34C12.5 Aff_C34C12.5 C34C12.5; C34C12.5.1; C34C12.5.2; 3E563; CE01513; WBGene00007924; WP:CE01513 RSP1 protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C C34C6.4 Aff_C34C6.4 C34C6.4; 2I988; CE03052; WBGene00007917; WP:CE03052 choline dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT C34D10.1 Aff_C34D10.1 C34D10.1; CE02532; WBGene00016406; WP:CE02532; XI649 ViswanathanM et al 2005 S2 sir-2.1 regulated C34D4.13 Aff_C34D4.13 C34D4.13; 4H896; CE34735; WBGene00016404; WP:CE34735 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C34D4.4 Aff_C34D4.4 C34D4.4; 4H913; CE06925; CE39683; WBGene00016400; WP:CE06925; WP:CE39683 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C34E10.7 Aff_C34E10.7 cnd-1; hlh-5; C34E10.7; 3G328; CE01187; NM_065714; WBGene00000561; WP:CE01187 cnd-1 is orthologous to the human gene NEUROGENIC DIFFERENTIATION 1 (NEUROD1; OMIM:601724), which when mutated leads to disease. C34E10.8 Aff_C34E10.8 C34E10.8; 3G340; CE32158; WBGene00016409; WP:CE32158 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen C34E7.4 Aff_C34E7.4 C34E7.4; CE03061; WBGene00007934; WP:CE03061; XN552 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol C34F11.4 Aff_C34F11.4 msp-50; C34F11.4; 2F491; NM_062571; WBGene00003443 msp-50 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C34F6.6 Aff_C34F6.6 C34F6.6; CE15675; WBGene00007940; WP:CE15675; XL826 ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT C34F6.8 Aff_C34F6.8 C34F6.8; C34F6.8.1; C34F6.8.2; C34F6.8.3; CE15677; WBGene00007942; WP:CE15677; XL835 Isocitrate and isopropylmalate dehydrogenases Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C34G6.5 Aff_C34G6.5 C34G6.5; 1G449; CE26909; WBGene00016421; WP:CE26909 ser/thr-protein kinase Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E C34G6.7 Aff_C34G6.7 pqn-19; C34G6.7; C34G6.7a.1; C34G6.7a.2; C34G6.7b.1; C34G6.7b.2; 1G480; CE29700; CE32816; NM_059309; NM_182013; WBGene00004109; WP:CE29700; WP:CE32816 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C35A5.8 Aff_C35A5.8 C35A5.8; 5L4; CE15680; WBGene00007952; WP:CE15680 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C35B1.5 Aff_C35B1.5 C35B1.5; C35B1.5.1; C35B1.5.2; C35B1.5.3; 4E848; CE16903; WBGene00016435; WP:CE16903 Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated C35B8.3 Aff_C35B8.3 C35B8.3; C35B8.3a.1; C35B8.3a.2; CE02536; CE27827; WBGene00016438; WP:CE02536; WP:CE27827; XJ835 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol C35C5.4 Aff_C35C5.4 mig-2; C35C5.4; CE18544; NM_077530; WBGene00003239; WP:CE18544; XM167 mig-2 encodes a member of the Rho family of GTP-binding proteins that affects the migration of Q neuroblasts, HSN cells, and CAN cells as well as axon outgrowth and guidance; it is expressed in early embryos and expressed in adults in the vulva, distal tip cells of the gonad, and the sex myoblasts and their descendants. RAS-related protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C35D10.10 Aff_C35D10.10 C35D10.10; 3F950; CE01191; WBGene00016446; WP:CE01191 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C35D10.13 Aff_C35D10.13 C35D10.13; 3F966; CE01194; WBGene00016449; WP:CE01194 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C35D10.9 Aff_C35D10.9 ced-4; C35D10.9; 3F943; CE01203; CE38154; WBGene00000418; WP:CE01203; WP:CE38154 ced-4 encodes a novel protein; along with CED-3, CED-4 is required for the initiation of programmed cell death; accordingly, genetic analyses indicate that ced-3 and ced-4 function upstream of ced-1, ced-2, and nuc-1 in the programmed cell death pathway; in yeast two-hybrid experiments, and upon coexpression in mammalian cells, CED-4 interacts with CED-9, an anti-apoptotic BCL-2 homolog; coexpression of CED-4 and CED-9 results in redistribution of CED-4 from the cytosol to organellar membranes, suggesting that CED-9 may negatively regulate CED-4 activity by sequestering CED-4 to intracellular membranes. Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C35D6.4 Aff_C35D6.4 C35D6.4; 4R103; CE15683; WBGene00007961; WP:CE15683 Zinc finger C-x8-C-x5-C-x3-H type (and similar). (2 domains) Lund et al 2002 Fig3D Oocyte-en, ViswanathanM et al 2005 S2 sir-2.1 regulated C35E7.1 Aff_C35E7.1 C35E7.1; 1L423; CE36273; NM_060435; WBGene00016453; WP:CE36273 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C36A4.8 Aff_C36A4.8 brc-1; C36A4.8; 3E944; CE31438; NM_065379; WBGene00000264; WP:CE31438 The brc-1 gene encodes a homolog of human BRCA1, which when mutated leads to early onset breast and ovarian cancer (OMIM:113705). Zinc finger, C3HC4 type (RING finger) Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C36B1.11 Aff_C36B1.11 C36B1.11; 1J332; CE05378; WBGene00007978; WP:CE05378 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C36B1.12 Aff_C36B1.12 imp-1; C36B1.12; C36B1.12a.1; C36B1.12a.2; C36B1.12c.1; C36B1.12c.2; 1J331; CE05379; CE38290; CE38291; WBGene00007979; WP:CE05379; WP:CE38290; WP:CE38291 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C36B1.5 Aff_C36B1.5 C36B1.5; C36B1.5.1; C36B1.5.2; 1J310; CE05372; WBGene00007972; WP:CE05372 U4/U6 small nuclear ribonucleoprotein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C36B7.6 Aff_C36B7.6 C36B7.6; C36B7.6.1; C36B7.6.2; CE34267; WBGene00016469; WP:CE34267; XH716 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C36E8.1 Aff_C36E8.1 C36E8.1; C36E8.1.1; C36E8.1.2; 3F90; CE00909; WBGene00007980; WP:CE00909 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C36E8.5 Aff_C36E8.5 rot-2; tbb-2; C36E8.5; C36E8.5.1; C36E8.5.2; C36E8.5.3; 3F106; CE00913; NM_065405; TUBB8; WBGene00006537; WP:CE00913 tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis. beta tubulin ViswanathanM et al 2005 S2 sir-2.1 regulated C37A2.5 Aff_F08B6.A pqn-21; C37A2.5; 1H350; CE27748; CE32818; WBGene00004111; WP:CE27748; WP:CE32818 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C37A2.7 Aff_C37A2.7 C37A2.7; C37A2.7.1; C37A2.7.2; 1H366; CE30433; WBGene00016493; WP:CE30433 ribosomal protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated C37A2.8 Aff_C37A2.8 C37A2.8; 1H376; CE08617; CE29218; WBGene00016494; WP:CE08617; WP:CE29218 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C37C3.2 Aff_C37C3.2 phi-18; C37C3.2; C37C3.2a.1; C37C3.2a.2; C37C3.2b.1; C37C3.2b.2; C37C3.2b.3; C37C3.2b.4; C37C3.2c.1; C37C3.2c.2; 5I337; CE27367; CE29707; CE32821; WBGene00016496; WP:CE27367; WP:CE29707; WP:CE32821 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C37C3.8 Aff_C37C3.8 tag-253; C37C3.8; C37C3.8a.1; C37C3.8a.2; C37C3.8a.3; C37C3.8a.4; 5I326; CE06933; CE30736; WBGene00016500; WP:CE06933; WP:CE30736 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C37E2.1 Aff_C37E2.1 C37E2.1; C37E2.1.1; C37E2.1.2; C37E2.1.3; CE08620; WBGene00007993; WP:CE08620; XO790 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. isocitrate dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C37H5.13 Aff_C37H5.13 C37H5.13; 5F336; CE27834; CE27835; CE39688; WBGene00016511; WP:CE27834; WP:CE27835; WP:CE39688 McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT C37H5.5 Aff_C37H5.5 C37H5.5; C37H5.5.1; C37H5.5.2; 5F313; CE29708; WBGene00016508; WP:CE29708 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C37H5.6 Aff_C37H5.6 C37H5.6; C37H5.6b.1; C37H5.6b.2; C37H5.6b.3; 5F298; CE08630; CE29709; WBGene00016509; WP:CE08630; WP:CE29709 adenylosuccinate synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C38C10.4 Aff_C38C10.4 ags-3.3; gpr-2; C38C10.4; 3K482; CE00107; NM_066665; WBGene00001689; WP:CE00107 gpr-2 encodes a protein containing a GPR (G Protein Regulator)/GoLoco motif characteristic of guanine nucleotide exchange factors specific for G-alpha GTPases; GPR-2 appears to function redundantly during early embryogenesis and germ-line development to regulate chromosome and spindle movements during cell division; GPR-2 likely acts as a positive regulator of G protein signaling and specifically, may regulate GOA-1 signaling in the embryo; GPR-2 forms a protein complex with the nearly identical GPR-1 and with LIN-5, a coiled-coil protein that is required for proper localization of GPR-2 to the cell cortex and spindle asters of the early embryo; in addition, proper GPR-2/GPR-1/LIN-5 localization between the P2 and EMS blastomeres at the four-cell stage, which may contribute to spindle positioning in EMS, requires the MES-1/SRC-1 tyrosine kinase signaling pathway; GPR-2 is believed to act downstream of, or in parallel to, PAR-3, a PDZ domain-containing protein, in mitotic spindle positioning in the early embryo. Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C38C10.5 Aff_C38C10.5 mdt-14; rgr-1; C38C10.5; 3K493; CE34528; CE34529; NM_066666; NM_066667; WBGene00004343; WP:CE34528; WP:CE34529 RGR1 (yeast) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C38C3.5 Aff_F53E2.C UNC-60A; unc-60; unc-66; C38C3.5; C38C3.5c.1; C38C3.5c.2; C38C3.5c.3; 5B957; CE20547; CE20549; CE31893; NM_071026; WBGene00006794; WP:CE20547; WP:CE20549; WP:CE31893 unc-60 encodes orthologs of actin depolymerizing factor/cofilin, actin-binding proteins that regulate actin filament dynamics; one UNC-60 isoform, UNC-60A, primarily binds G-actin, depolymerizes actin filaments, and inhibits actin polymerization; UNC-60A is essential during early embryonic development for polar body extrusion, cytokinesis, and embryonic patterning; UNC-60B, which does not inhibit actin polymerization, binds F- and G-actin and influences the rate of actin polymerization by the UNC-60B:actin ratio; UNC-60B is required for actin filament organization in body wall muscle, locomotion, and for efficient actin filament disassembly by UNC-78, an actin interactin protein 1 (AIP1) ortholog; UNC-60A and UNC-60B are differentially expressed: UNC-60A is found in oocytes, embryos, and the adult gonad and intestine, while UNC-60B is found in body wall muscle, the vulva, and spermatheca. Roy et al 2002 S2 positivecontrol L1 muscle, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C38D4.3 Aff_C38D4.3 C38D4.3; 3F881; CE36378; WBGene00008004; WP:CE36378 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol C38D4.5 Aff_C38D4.5 tag-325; C38D4.5; C38D4.5.1; C38D4.5.2; 3F891; CE00918; WBGene00008006; WP:CE00918 chimaerin McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma C38D4.6 Aff_C38D4.6 ceh-3; nob-2; pal-1; C38D4.6; C38D4.6a.1; C38D4.6a.2; C38D4.6b.1; C38D4.6b.2; 3F896; CE05383; CE27837; NM_065590; WBGene00003912; WP:CE05383; WP:CE27837 pal-1 encodes a homeodomain protein that is the C. elegans Caudal ortholog; PAL-1 is required maternally and embryonically for cell fate specification and posterior patterning during embryogenesis; PAL-1 is also required postembryonically for fate specification of the posterior V6 neuroectoblast during male tail development; PAL-1 is expressed in posterior blastomeres beginning at the four-cell stage of embryogenesis and its expression continues during embryogenesis in posterior-derived tissues and cells undergoing movement or forming midline structures; pal-1 is subject to both transcriptional and translational regulation. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E C38D4.9 Aff_C38D4.9 C38D4.9; C38D4.9.1; C38D4.9.2; 3F893; CE00922; WBGene00008008; WP:CE00922 methylase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C39D10.8 Aff_C39D10.4 C39D10.8; CE29713; CE29714; CE30501; WBGene00016535; WP:CE29713; WP:CE29714; WP:CE30501; XI498 Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C39E9.11 Aff_C39E9.11 C39E9.11; 4N856; CE20559; WBGene00008034; WP:CE20559 C39E9.11 is orthologous to the human gene PAPILLARY RENAL CELL CARCINOMA (TRANSLOCATION-ASSOCIATED) (PRCC; OMIM:179755), which when mutated leads to disease. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C39E9.12 Aff_C39E9.12 C39E9.12; 4N859; CE39690; WBGene00008035; WP:CE39690 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C39E9.13 Aff_C39E9.13 rfc-3; C39E9.13; 4N861; CE05396; NM_070116; WBGene00004339; WP:CE05396 Human activator 1 38 KD subunit like Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C39E9.14 Aff_C39E9.14 dli-1; C39E9.14; C39E9.14a.1; C39E9.14a.2; 4N862; CE30892; CE30893; NM_070117; NM_070118; WBGene00001007; WP:CE30892; WP:CE30893 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C39F7.2 Aff_Y50D4A_25.A C39F7.2; C39F7.2.1; C39F7.2.2; 5B704; CE27581; WBGene00016539; WP:CE27581 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C39F7.4 Aff_C39F7.4 rab-1; C39F7.4; C39F7.4.1; C39F7.4.2; 5B742; CE16905; NM_070996; WBGene00004266; WP:CE16905 rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline. RAS-related protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C40H1.6 Aff_C40H1.6 C40H1.6; 3K421; CE00114; WBGene00008041; WP:CE00114 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Roy et al 2002 S3 muscle genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C41A3.1 Aff_C41A3.1 C41A3.1; CE04187; WBGene00016558; WP:CE04187; XG59 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. polyketide synthase C41C4.6 Aff_C41C4.6 ulp-4; C41C4.6; 2I423; CE01521; NM_063302; WBGene00006739; WP:CE01521 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C41C4.8 Aff_C41C4.8 cdc-48.2; C41C4.8; C41C4.8.1; C41C4.8.2; C41C4.8.3; 2I431; CE05402; NM_063304; WBGene00008053; WP:CE05402 P97 protein Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C41D11.2 Aff_C41D11.2 eif-3.H; C41D11.2; 1F13; CE29220; NM_058969; WBGene00001231; WP:CE29220 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, male germline, Reinke et al 2004, wt males vs glp4 male enriched , Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C41D11.7 Aff_C41D11.7 C41D11.7; 1F20; CE36108; WBGene00016566; WP:CE36108 DNA-binding protein Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C41G7.1 Aff_C41G7.1 smn-1; C41G7.1; 1K88; CE08665; CE27843; CESMN; NM_060124; SMN; WBGene00004887; WP:CE08665; WP:CE27843 smn-1 encodes a homolog of human SMN, which when mutated leads to spinal muscular atrophy (OMIM:253300). Human muscular atrophy protein like Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C41G7.3 Aff_C41G7.3 C41G7.3; 1K94; CE08667; WBGene00008061; WP:CE08667 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C41H7.3 Aff_C41H7.3 C41H7.3; 2D297; CE08674; WBGene00016573; WP:CE08674 ViswanathanM et al 2005 S2 sir-2.1 regulated C41H7.4 Aff_C41H7.4 C41H7.4; 2D295; CE08675; WBGene00016574; WP:CE08675 ViswanathanM et al 2005 S2 sir-2.1 regulated C41H7.6 Aff_C41H7.6 C41H7.6; 2D291; CE08677; WBGene00016576; WP:CE08677 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C42C1.11 Aff_C42C1.11 AP-1; C42C1.11; C42C1.11a.1; C42C1.11a.2; C42C1.11c.1; C42C1.11c.2; 4N45; CE24840; CE33564; CE33565; WBGene00016589; WP:CE24840; WP:CE33564; WP:CE33565 peptidase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C42C1.16 Aff_C42C1.10 C42C1.16; 4N49; CE29223; WBGene00016593; WP:CE29223 C42C1.5 Aff_C42C1.5 tag-335; C42C1.5; 4N40; CE16911; WBGene00016583; WP:CE16911 guanyltransferase Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C42D4.6 Aff_C42D4.6 skr-16; C42D4.6; 4H931; CE37712; NM_068727; WBGene00004822; WP:CE37712 The skr-16 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-16(RNAi) animals are at least superficially normal. C42D8.3 Aff_C42D8.3 uvt-3; C42D8.3; CE04204; NM_076465; WBGene00006862; WP:CE04204; XF711 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C43E11.10 Aff_C43E11.10 cdc-6; C43E11.10; 1E838; CE08688; NM_058942; WBGene00000382; WP:CE08688 cdc-6 encodes a homolog of an origin complex component (CDC6) which in yeast controls the start of DNA replication, and also has a distant paralog (Y39A1A.12) within the C. elegans genome; CDC-6 is superficially dispensable for embryonic viability, perhaps because of redundancy with Y39A1A.12. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C43E11.7 Aff_C43E11.7 ndx-7; C43E11.7; 1E808; CE30504; NM_058935; WBGene00003584; WP:CE30504 ndx-7 encodes a NUDIX hydrolase; by sequence comparison, NDX-7 is predicted to function as a pyrophosphatase, and is most closely related to the mouse RP2 protein that has unknown substrate specificity but is regulated transcriptionally by the presence of androgens; in C. elegans, loss of ndx-7 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, consistent with the proposed nonessential roles for Nudix proteins in eliminating potentially toxic nucleotide metabolites from cells and modulating levels of metabolic intermediates by shuttling them into alternative biochemical pathways. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C43E11.8 Aff_C43E11.8 C43E11.8; 1E812; CE08686; WBGene00016606; WP:CE08686 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C43E11.9 Aff_C43E11.9 C43E11.9; C43E11.9.1; C43E11.9.2; 1E836; CE08687; WBGene00016607; WP:CE08687 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C43H6.1 Aff_C43H6.1 C43H6.1; CE37619; WBGene00016614; WP:CE37619; XD31 Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C43H6.4 Aff_C43H6.4 C43H6.4; CE33917; WBGene00016617; WP:CE33917; XD25 Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C43H6.7 Aff_C43H6.7 C43H6.7; CE06958; WBGene00016620; WP:CE06958; XD16 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C43H8.1 Aff_C43H8.1 C43H8.1; C43H8.1.1; C43H8.1.2; 1L201; CE19377; WBGene00016621; WP:CE19377 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C43H8.2 Aff_C43H8.2 C43H8.2; 1L199; CE19378; WBGene00016622; WP:CE19378 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C44B7.1 Aff_C44B7.1 C44B7.1; C44B7.1.1; C44B7.1.2; C44B7.1.3; C44B7.1.4; 2H191; CE25810; P27; WBGene00016623; WP:CE25810 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes C44B7.2 Aff_C44B7.2 C44B7.2; C44B7.2a.1; C44B7.2a.2; CE25812; CE34752; WBGene00016624; WP:CE25812; WP:CE34752 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C44B9.3 Aff_C44B9.3 C44B9.3; 3L966; CE05405; WBGene00008080; WP:CE05405 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C44B9.5 Aff_C44B9.5 C44B9.5; 3L989; CE37755; WBGene00008082; WP:CE37755 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C44C1.1 Aff_C44C1.1 C44C1.1; CE35432; WBGene00016641; WP:CE35432; XB601 Romagnolo et al 2002 Fig3b Unkown, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C44C1.2 Aff_C44C1.2 C44C1.2; CE30126; WBGene00016642; WP:CE30126; XB577 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B C44C10.8 Aff_C44C10.8 hlh-18; hlh-22; hnd-1; C44C10.8; CE05415; NM_077551; WBGene00001981; WP:CE05415; XM301 hnd-1 encodes a Hand bHLH transcription factor required for normal viability, gonadogenesis, and posterior body morphology; HND-1 is required for the formation of both somatic gonadal precursors and primordial germ cells, but not for later gonadogenesis; HND-1 is expressed embryogenesis in embryonic mesodermal precursor cells generating (mostly) body wall muscle, in somatic gonad precursor cells, and in some unidentified head cells; the primary defect in hnd-1 mutants may be, nonautonomously, in mesodermal precursor cells; somatic gonad precursor cells are normally generated in hnd-1 mutants, but not maintained. Helix-loop-helix DNA-binding domain Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes C44C8.6 Aff_C44C8.6 mak-2; C44C8.6; C44C8.6b.1; C44C8.6b.2; 4B641; CE17545; CE33566; NM_067604; NM_067605; WBGene00007007; WP:CE17545; WP:CE33566 protein kinase ViswanathanM et al 2005 S2 sir-2.1 regulated C44E4.4 Aff_C44E4.4 C44E4.4; C44E4.4.1; C44E4.4.2; 1F203; CE08718; WBGene00016653; WP:CE08718 RNA-binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C44E4.6 Aff_C44E4.6 acbp-1; C44E4.6; C44E4.6.1; C44E4.6.2; C44E4.6.3; C44E4.6.4; 1F204; CE08720; NM_059011; WBGene00016655; WP:CE08720 acyl-CoA-binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C44F1.3 Aff_C44F1.3 lec-4; C44F1.3; 3E862; CE02163; NM_065362; WBGene00002267; WP:CE02163 lec-4 encodes a predicted galectin that exhibits sugar binding properties in vitro. galactoside binding lectin Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C44H4.5 Aff_C44H4.5 tap-1; C44H4.5; CE08726; NM_078027; WBGene00006524; WP:CE08726; XP209 Protein phosphatase 2C Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C44H4.7 Aff_C44H4.7 eor-2; C44H4.7; CE31445; CE31446; WBGene00001325; WP:CE31445; WP:CE31446; XP225 eor-2 encodes an unfamiliar protein, similar to CG17233 in Drosophila and KIAA1205 in H. sapiens, required for signal transduction by both RAS and Wnt pathways in both excretory system development and P12 fate specification. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C45B11.1 Aff_C45B11.1 pak-4; tag-66; C45B11.1; 5L518; CE05425; CE20564; WBGene00006443; WP:CE05425; WP:CE20564 P21-Rho-binding domain ; Eukaryotic protein kinase domain Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C45B2.5 Aff_C45B2.5 gln-1; C45B2.5; C45B2.5.1; C45B2.5.2; CE27854; NM_076611; WBGene00001602; WP:CE27854; XG677 Glutamine synthetase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated C45E5.6 Aff_C45E5.6 nhr-46; C45E5.6; C45E5.6a.1; C45E5.6a.2; C45E5.6c.1; C45E5.6c.2; C45E5.6c.3; C45E5.6c.4; C45E5.6c.5; C45E5.6c.6; C45E5.6c.7; C45E5.6c.8; 4G512; CE08734; CE29226; CE29227; NM_068457; WBGene00003636; WP:CE08734; WP:CE29226; WP:CE29227 nuclear hormone receptor ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C45G3.1 Aff_C45G3.1 tag-255; C45G3.1; 1J798; CE15710; WBGene00008107; WP:CE15710 The C45G3.1 gene encodes a protein, with one N-terminal calponin-like actin-binding domain and two IQ calmodulin-binding domains, that is likely to be required for spindle structure and function, and (indirectly) for neural function, based on its orthology to Drosophila ABNORMAL SPINDLE and on its joint sterile and uncoordinated RNAi phenotypes; C45G3.1 is also orthologous to human ASPM (OMIM:605481), which when mutated leads to primary microcephaly; C45G3.1 is required for embryonic and larval viability, germline maintenance, vulval morphogenesis, meiosis, and locomotion. Actinin-type actin-binding domain containing proteins McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen C45G3.5 Aff_C45G3.3 C45G3.5; C45G3.5.1; C45G3.5.2; CE37812; WBGene00044008; WP:CE37812 C45G7.4 Aff_C45G7.4 C45G7.4; 4D199; CE17550; WBGene00016671; WP:CE17550 zinc finger protein ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT C45G9.5 Aff_C45G9.5 C45G9.5; 3G139; CE01856; WBGene00016676; WP:CE01856 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C45H4.14 Aff_C45H4.14 C45H4.14; 5C638; CE08747; CE32829; WBGene00016695; WP:CE08747; WP:CE32829 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C46A5.9 Aff_C46A5.9 hcf-1; C46A5.9; 4I536; CE26914; NM_068878; WBGene00001827; WP:CE26914 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C46C2.1 Aff_C46C2.1 wnk-1; C46C2.1; 4J975; CE37331; CE37332; NM_069202; NM_182275; WBGene00006941; WP:CE37331; WP:CE37332 wnk-1 is orthologous to the human gene PROTEIN KINASE, LYSINE-DEFICIENT 1 (PRKWNK1; OMIM:605232), which when mutated leads to pseudohypoaldosteronism type II. serine/threonine kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C46C2.2 Aff_C46C2.2 C46C2.2; C46C2.2.1; C46C2.2.2; 4J983; CE32832; WBGene00008110; WP:CE32832 transport protein Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol C46E10.4 Aff_C46E10.4 C46E10.4; 2E9; CE29724; WBGene00016710; WP:CE29724 ViswanathanM et al 2005 S2 sir-2.1 regulated C46F11.2 Aff_C46F11.2 C46F11.2; C46F11.2b.1; C46F11.2b.2; 3E741; CE08773; CE17558; WBGene00008117; WP:CE08773; WP:CE17558 C46F11.2 is orthologous to human MITOCHONDRIAL GLUTATHIONE REDUCTASE (GSR; OMIM:138300); GSR deficiency has been associated with hemolytic anemia. McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 C46F11.4 Aff_C46F11.4 C46F11.4; C46F11.4.1; C46F11.4.2; 3E748; CE17559; WBGene00008119; WP:CE17559 ATP-dependent RNA helicase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen C46H11.2 Aff_C46H11.2 C46H11.2; 1F619; CE08784; WBGene00016728; WP:CE08784 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 C46H3.2 Aff_C46H3.2 C46H3.2; C46H3.2b.1; C46H3.2b.2; CE29228; CE33921; WBGene00016725; WP:CE29228; WP:CE33921; XB832 tyrosine-protein kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C47A10.6 Aff_C47A10.6 srab-12; C47A10.6; 5S256; CE15719; NM_075091; WBGene00008128; WP:CE15719 ViswanathanM et al 2005 S2 sir-2.1 regulated C47B2.2 Aff_C47B2.2 C47B2.2; C47B2.2b.1; C47B2.2b.2; CE17562; CE23599; WBGene00008131; WP:CE17562; WP:CE23599 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C47B2.3 Aff_C47B2.3 mel-45; tba-2; C47B2.3; C47B2.3.1; C47B2.3.2; C47B2.3.3; 1N558; CE17563; NM_060869; TUBA4B; WBGene00006529; WP:CE17563 tba-2 encodes a tubulin with similarity to the murine alpha-2 chain; in small scale assays tba-1(RNAi) has no phenotype and was found to function redundantly with its isotype tba-1 to form spindle structures in embryos with the tbb-1 and tbb-2 beta-isotypes. Tubulin McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated C47B2.5 Aff_C47B2.5 eif-6; C47B2.5; C47B2.5.1; C47B2.5.2; 1N561; CE17565; NM_060871; WBGene00001234; WP:CE17565 EUKARYOTIC TRANSLATION INITIATION FACTOR 6 (EIF-6) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C47D12.1 Aff_C47D12.1 trr-1; C47D12.1; C47D12.1b.1; C47D12.1b.2; 2L952; CE36692; CE36693; CE38054; WBGene00007028; WP:CE36692; WP:CE36693; WP:CE38054 Yeast YHP9 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C47E12.4 Aff_C47E12.4 pyp-1; C47E12.4; C47E12.4c.1; C47E12.4c.2; C47E12.4c.3; C47E12.4d.1; C47E12.4d.2; C47E12.4d.3; 4K760; CE05448; CE33767; CE33768; CE33769; WBGene00008149; WP:CE05448; WP:CE33767; WP:CE33768; WP:CE33769 inorganic pyrophosphatase Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C47E12.7 Aff_C47E12.7 C47E12.7; 4K746; CE20571; WBGene00008151; WP:CE20571 Yeast YD78 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C47E8.4 Aff_C47E8.4 C47E8.4; 5P164; CE35838; WBGene00008143; WP:CE35838 Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C47E8.7 Aff_C47E8.7 unc-112; C47E8.7; C47E8.7.1; C47E8.7.2; 5P172; CE05443; NM_074227; WBGene00006836; WP:CE05443 The unc-112 gene encodes a pleckstrin homology domain-containing protein, orthologous to human Mitogen inducible gene-2, that is required for assembly of muscle dense bodies and M lines during embryogenesis; UNC-112 is a dense body/M-line component and requires PAT-3/beta-integrin, UNC-52/perlecan, and PAT-4/integrin-linked kinase for proper localization; UNC-112 binds PAT-4 directly, forms a ternary complex with PAT-4 and PAT-6/actopaxin, and is required for recruitment of PAT-3 and PAT-4 to muscle cell attachment sites; viable unc-112 mutations are suppressed by mutation of dim-1. mitogen inducible MIG-2 protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C C47G2.5 Aff_C47G2.5 C47G2.5; C47G2.5.1; C47G2.5.2; 2L591; CE38162; WBGene00008166; WP:CE38162 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma C48B6.2 Aff_C48B6.2 C48B6.2; C48B6.2.1; C48B6.2.2; 1H493; CE08804; WBGene00016740; WP:CE08804 ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C48B6.9 Aff_C48B6.9 C48B6.9; 1H502; CE08811; WBGene00016745; WP:CE08811 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C48E7.2 Aff_C48E7.2 C48E7.2; 1G833; CE08817; WBGene00016750; WP:CE08817 Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Protein Synthesis C48E7.3 Aff_C48E7.3 lpd-2; C48E7.3; 1G831; CE29953; NM_059405; WBGene00003059; WP:CE29953 lpd-2 encodes a predicted transcription factor with homology to transcription factors of the CCAAT/Enhancer Binding Protein family (C/EBPA and B, OMIM:116897, 189965, associated with the regulation of mammalian adipocyte differentiation); in C. elegans, LPD-2 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for larval development; in addition, LPD-2 may be part of a conserved pathway regulating lipogenesis, as LPD-2 appears to positively regulate expression of sbp-1, which encodes the C. elegans Sterol Regulatory Element Binding Protein (SREBP) homolog, a basic helix-loop-helix-type transcription factor also required for normal lipid metabolism and larval development. Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b TF, ViswanathanM et al 2005 S2 sir-2.1 regulated C49C3.15 Aff_C49C3.15 C49C3.15; 4S279; CE37493; WBGene00008204; WP:CE37493 C49C3.6 Aff_C49C3.6 C49C3.6; 4S275; CE19745; WBGene00008196; WP:CE19745 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C49C3.7 Aff_C49C3.7 C49C3.7; 4S277; CE19746; WBGene00008197; WP:CE19746 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E C49C3.8 Aff_C49C3.8 C49C3.8; 4S281; CE19747; WBGene00008198; WP:CE19747 Jones et al 2001 Dauer specific genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit C49H3.6 Aff_C49H3.6 C49H3.6; 4I671; CE29380; CE30506; WBGene00016792; WP:CE29380; WP:CE30506 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C49H3.8 Aff_C49H3.8 C49H3.8; 4I664; CE04234; WBGene00016793; WP:CE04234 actin-like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C49H3.9 Aff_C49H3.9 C49H3.9; 4I672; CE27873; WBGene00016794; WP:CE27873 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C50B6.3 Aff_C50B6.3 C50B6.3; 5N795; CE08872; WBGene00008219; WP:CE08872 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C50B8.3 Aff_C50B8.3 C50B8.3; 5O46; CE08883; WBGene00008225; WP:CE08883 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C50C3.6 Aff_C50C3.6 prp-8; C50C3.6; 3J261; CE00122; NM_066384; WBGene00004187; WP:CE00122 prp-8 is orthologous to the human gene SIMILAR TO U5 SNRNP-SPECIFIC PROTEIN (220 KD), ORTHOLOG OF S. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes C50E10.4 Aff_C44C11.2 sop-2; C50E10.4; 2M633; CE32334; NM_064220; WBGene00004945; WP:CE32334 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C50E3.5 Aff_C50E3.4 C50E3.5; 5I75; CE30738; WBGene00016816; WP:CE30738 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen C50F2.6 Aff_C50F2.6 dao-8; fkb-5; C50F2.6; C50F2.6a.1; C50F2.6a.2; 1E466; CE08912; CE27878; NM_058856; NM_058857; WBGene00001430; WP:CE08912; WP:CE27878 fkb-5 encodes a homolog of human FK506 binding protein 9. Link et al 2003 T2 Abeta repressed, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C50F4.13 Aff_C50F4.13 his-35; C50F4.13; C50F4.13.1; C50F4.13.2; C50F4.13.3; 5K22; CE05477; NM_073062; WBGene00001909; WP:CE05477 his-35 encodes an H2A histone. histone H2A McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated C50F4.16 Aff_C50F4.11 C50F4.16; C50F4.16.1; C50F4.16.2; 5K18; CE28213; WBGene00008238; WP:CE28213 The C50F4.16 gene encodes a NUDIX hydrolase. C50F4.5 Aff_C50F4.5 his-41; C50F4.5; CE05470; NM_073063; WBGene00001915; WP:CE05470 his-41 encodes an H2B histone. histone H2B McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C50F4.6 Aff_C50F4.6 his-36; C50F4.6; 5K25; CE05471; NM_073064; WBGene00001910; WP:CE05471 his-36 encodes an UNSPECIFIED histone. C50F4.7 Aff_C50F4.7 his-37; C50F4.7; 5K27; NM_073065; WBGene00001911 his-37 encodes an H4 histone. histone H4 ViswanathanM et al 2005 S2 sir-2.1 regulated C50F7.4 Aff_C50F7.4 C50F7.4; 4I495; CE04242; SCB2; WBGene00016844; WP:CE04242 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. succinyl-CoA synthetase beta chain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C52B9.7 Aff_C52B9.7 paf-2; C52B9.7; CE30264; CE30265; NM_171668; WBGene00003907; WP:CE30264; WP:CE30265; XE910 paf-2 encodes a homolog of vertebrate Type II Platelet-activating factor-acetylhydrolase (PAF-AH) that is 70% identical to PAF-2 that is required for embryogenesis and affects organization of the hypodermis. ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C52B9.8 Aff_C52B9.8 C52B9.8; CE27114; WBGene00016868; WP:CE27114; XE918 helicase ViswanathanM et al 2005 S2 sir-2.1 regulated C52D10.9 Aff_C52D10.9 skr-8; C52D10.9; C52D10.9.1; C52D10.9.2; 4S108; CE17593; NM_070643; WBGene00004814; WP:CE17593 skr-8 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-8 is required for is required for posterior body morphogenesis, embryonic and larval development, and cell proliferation; SKR-8 can interact with CUL-1, a C. elegans cullin homolog. cyclin A-associated protein Kwon et al 2004 T1 late-repression Ethanol-respon, Lund et al 2002 Fig3D Oocyte-en, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C52E2.6 Aff_C52E2.B fbxb-97; C52E2.6; C52E2.B; 2C122; CE36808; WBGene00016885; WP:CE36808 C52E4.2 Aff_C52E4.2 mif-2; C52E4.2; C52E4.2.1; C52E4.2.2; 5M458; CE08944; NM_073602; WBGene00003235; WP:CE08944 macrophage migration inhibitory factor like protein ViswanathanM et al 2005 S2 sir-2.1 regulated C52E4.3 Aff_C52E4.3 snr-4; C52E4.3; C52E4.3.1; C52E4.3.2; 5M460; CE08945; NM_073603; WBGene00004917; WP:CE08945 small nuclear ribonucleoprotein D2 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories C53A5.3 Aff_C53A5.3 gon-10; hda-1; C53A5.3; C53A5.3.1; C53A5.3.2; 5P7; CE08952; NM_074198; WBGene00001834; WP:CE08952 The hda-1 gene encodes a histone deacetylase 1, similar to histone deacetylases RPD3 from yeast and fly; maternal and zygotic expression of hda-1 is required for embryonic viability, and zygotic expression of hda-1 is also required for gonadogenesis and vulval development. Yeast RPD3 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C53B4.6 Aff_C53B4.6 C53B4.6; 4J751; CE03092; WBGene00008275; WP:CE03092 Yeast YEA4 like protein McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C53B7.4 Aff_C53B7.4 asg-2; C53B7.4; C53B7.4.1; C53B7.4.2; CE06974; NM_076751; WBGene00000210; WP:CE06974; XH461 asg-2 encodes a homolog of ATP synthase G required both for growth at a normally high rate and for normal osmoregulation. ATP synthase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C53D5.5 Aff_C53D5_1638.C C53D5.5; C53D5.5.1; C53D5.5.2; C53D5.5.3; CE23612; NM_058313; WBGene00016906; WP:CE23612 The C53D5.5 gene encodes an ortholog of the human gene GAMMA-GLUTAMYLTRANSFERASE 1 (GGT1), which when mutated leads to glutathionuria (OMIM:231950). gamma-glutamyltranspeptidase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C53D5.6 Aff_C53D5_1638.A imb-3; C53D5.6; C53D5.A; 1A780; CE26971; NM_058314; WBGene00002077; WP:CE26971 imb-3 encodes an importin-beta-like protein orthologous to Drosophila, vertebrate, and yeast importin/karyopherin-beta3; IMB-3 is predicted to function as a nuclear transport factor that, with the RAN-1 GTPase, regulates nuclear import of ribosomal proteins; in C. elegans, IMB-3 is essential for embryogenesis and germline development, and may also be required for normal postembryonic growth rates. importin beta, nuclear transport factor McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes C53D6.4 Aff_C53D6.4 C53D6.4; 4J784; CE36284; WBGene00008281; WP:CE36284 angiotensin receptor like Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C54A12.1 Aff_C54A12.1 ptr-6; C54A12.1; 2F534; CE39341; NM_062585; WBGene00004221; WBGene00016908; WP:CE39341 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 C54C6.1 Aff_C54C6.1 rpl-37; C54C6.1; C54C6.1.1; C54C6.1.2; 3E619; CE05493; NM_065326; WBGene00004451; WP:CE05493 rpl-37 encodes a large ribosomal subunit L37 protein. 60S ribosomal protein L37 ViswanathanM et al 2005 S2 sir-2.1 regulated C54G10.2 Aff_C54G10.2 rfc-1; C54G10.2; 5P124; CE20613; NM_074218; WBGene00004337; WP:CE20613 replication factor C 140 KD subunit like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen C54G10.4 Aff_C54G10.4 C54G10.4; 5P134; CE05519; CE32337; WBGene00008320; WP:CE05519; WP:CE32337 mitochrondrial carrier protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C54G4.6 Aff_C54G4.6 dod-18; C54G4.6; 1I594; CE05512; NM_059804; WBGene00008316; WP:CE05512 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. MAF protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C54G4.8 Aff_C54G4.8 cyc-1; C54G4.8; C54G4.8.1; C54G4.8.2; 1I600; CE05514; NM_059806; WBGene00000869; WP:CE05514 cyc-1 encodes a component of complex III ( cytochrome c reductase) required for normal ATP production; reduction of ATP production by cyc-1(RNAi) decreases growth rate and body size, slows behavior, and increases lifespan; cyc-1 encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial cytochrome C1, heme protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C54G4.9 Aff_C54G4.9 C54G4.9; 1I602; CE05515; WBGene00008318; WP:CE05515 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C54G7.2 Aff_C54G7.2 C54G7.2; C54G7.2.1; C54G7.2.2; CE04270; WBGene00016934; WP:CE04270; XG140 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C54G7.4 Aff_C54G7.4 C54G7.4; CE37621; WBGene00016935; WP:CE37621; XG166 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C54H2.3 Aff_C54H2.3 tag-294; C54H2.3; CE06985; WBGene00016937; WP:CE06985; XG380 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C55A6.2 Aff_C55A6.2 C55A6.2; 5L991; CE29733; WBGene00008331; WP:CE29733 Human KIAA0173 protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C55A6.9 Aff_C55A6.9 C55A6.9; 5M3; CE20614; WBGene00008338; WP:CE20614 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C55B7.8 Aff_C55B7.8 Ce-dbr1; dbr-1; C55B7.8; 1H68; CE30437; NM_059467; WBGene00000937; WP:CE30437 dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels. lariat debranching enzyme McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C55B7.9 Aff_C55B7.9 mdt-18; C55B7.9; C55B7.9.1; C55B7.9.2; 1H70; CE09020; NM_059468; WBGene00007018; WP:CE09020 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C56A3.5 Aff_C56A3.5 C56A3.5; 5O31; CE09033; WBGene00008344; WP:CE09033 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C56A3.6 Aff_C56A3.6 C56A3.6; 5O34; CE32339; WBGene00008345; WP:CE32339 EF hand (2 domains) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C56C10.10 Aff_C56C10.10 C56C10.10; 2G884; CE02564; WBGene00016966; WP:CE02564 TPR domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C56C10.3 Aff_C56C10.3 phi-27; tag-309; C56C10.3; C56C10.3.1; C56C10.3.2; 2G881; CE02568; WBGene00016961; WP:CE02568 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C56G2.15 Aff_C56G2.15 C56G2.15; 3H456; CE01870; WBGene00016983; WP:CE01870 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C56G7.1 Aff_C56G7.1 mlc-4; C56G7.1; C56G7.1.1; C56G7.1.2; 3E482; CE01531; NM_065299; WBGene00003372; WP:CE01531 myosin regulatory light chain 2 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol CD4.2 Aff_CD4.2 crn-2; CD4.2; 5G75; CE16950; NM_072075; WBGene00000795; WP:CE16950 crn-2 encodes a cell death-related nuclease, homologous to the magnesium-dependant TatD nuclease of E. coli; CRN-2 is required for normal levels of DNA degradation during apoptosis; crn-2(RNAi) 1.5-fold stage embryos display TUNEL labelling of nuclei that is five-fold higher than that seen in untreated N2 animals; CRN-2 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-3 but is parallel to CPS-6; CRN-2 is predicted to be mitochondrial. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated CD4.3 Aff_CD4.3 CD4.3; CD4.3.1; CD4.3.2; 5G73; CE16951; WBGene00016989; WP:CE16951 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated CD4.4 Aff_CD4.4 CD4.4; 5G71; CE16952; WBGene00016990; WP:CE16952 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated CD4.7 Aff_CD4.7 CD4.7; 5G74; CE35262; WBGene00016992; WP:CE35262 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated D1007.12 Aff_D1007.12 rpl-24.1; RPL-24; D1007.12; D1007.12.1; D1007.12.2; 1F153; CE09047; NM_058998; WBGene00004436; WP:CE09047 rpl-24.1 encodes a large ribosomal subunit L24 protein. 60S ribosomal protein L24 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated D1007.5 Aff_D1007.5 D1007.5; D1007.5a.1; D1007.5a.2; D1007.5b.1; D1007.5b.2; 1F150; CE29034; CE33577; WBGene00017003; WP:CE29034; WP:CE33577 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated D1007.6 Aff_D1007.6 rps-10; D1007.6; D1007.6.1; D1007.6.2; 1F152; CE09041; NM_058997; WBGene00004479; WP:CE09041 rps-10 encodes a small ribosomal subunit S10 protein. 40S ribosomal protein S10 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol D1007.7 Aff_D1007.7 D1007.7; 1F166; CE26916; WBGene00017004; WP:CE26916 RNA-binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order D1009.1 Aff_D1009.1 D1009.1; CE04285; CE27891; WBGene00017012; WP:CE04285; WP:CE27891; XJ557 fatty acid transporter protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 D1009.2 Aff_D1009.2 cyn-8; cyp-8; D1009.2; CE04286; CE27892; NM_077105; WBGene00000884; WP:CE04286; WP:CE27892; XJ531 cyp-8 encodes a peptidyl-propyl cis-trans isomerase of the cyclophilin family; cyclophilins are implicated in protein folding, however the precise role of cyp-8 is not known; a CYP-8-fusion protein localises specifically to gut cell nuclei. ViswanathanM et al 2005 S2 sir-2.1 regulated D1014.3 Aff_D1014.3 phi-29; D1014.3; D1014.3.1; D1014.3.2; 5I613; CE38494; WBGene00017016; WP:CE38494 alpha-SNAP protein Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated D1014.8 Aff_D1014.8 spr-1; D1014.8; 5I608; CE27749; NM_072697; WBGene00005006; WP:CE27749 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated D1022.1 Aff_D1022.1 ubc-6; D1022.1; 2H771; CE29241; CE39712; NM_063165; WBGene00006703; WP:CE29241; WP:CE39712 Ubiquitin-conjugating enzyme Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol D1022.4 Aff_D1022.4 D1022.4; 2H746; CE02578; WBGene00017023; WP:CE02578 ViswanathanM et al 2005 S2 sir-2.1 regulated D1043.1 Aff_D1043.1 D1043.1; 2L877; CE32842; WBGene00008361; WP:CE32842 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated D1044.1 Aff_D1044.1 D1044.1; 3G635; CE39140; WBGene00017027; WP:CE39140 ViswanathanM et al 2005 S2 sir-2.1 regulated D1046.1 Aff_D1046.1 D1046.1; D1046.1.1; D1046.1.2; D1046.1.3; D1046.1.4; 4J693; CE03094; WBGene00008362; WP:CE03094 glycine-rich RNA-binding protein Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen D1054.1 Aff_D1054.1 D1054.1; 5L248; CE35445; WBGene00008370; WP:CE35445 Human GS2 protein like ViswanathanM et al 2005 S2 sir-2.1 regulated D1054.13 Aff_D1054.13 D1054.13; 5L284; CE05531; WBGene00008379; WP:CE05531 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated D1054.14 Aff_D1054.14 D1054.14; D1054.14.1; D1054.14.2; 5L286; CE05532; WBGene00008380; WP:CE05532 Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated D1069.4 Aff_D1069.4 D1069.4; 2A642; CE17616; WBGene00017038; WP:CE17616 D1081.6 Aff_D1081.6 D1081.6; 1J54; CE05538; WBGene00008384; WP:CE05538 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E D1081.8 Aff_D1081.8 phi-7; D1081.8; D1081.8.1; D1081.8.2; 1J71; CE05540; WBGene00008386; WP:CE05540 MYB transforming protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E D2005.1 Aff_D2005.1 D2005.1; 1I360; CE09065; WBGene00008397; WP:CE09065 RNA adenosine deaminase like D2005.5 Aff_D2005.5 drh-3; ekl-3; D2005.5; 1I401; CE36120; WBGene00008400; WP:CE36120 RNA helicase like Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Romagnolo et al 2002 Fig3b Metabolism, ViswanathanM et al 2005 S2 daf-16 Resveratrol D2007.5 Aff_D2007.5 D2007.5; D2007.5.1; D2007.5.2; 3J246; CE00130; WBGene00017045; WP:CE00130 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated D2013.10 Aff_D2013.10 tag-175; D2013.10; 2J613; CE17622; WBGene00006520; WBGene00008406; WP:CE17622 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph D2013.6 Aff_D2013.6 D2013.6; 2J621; CE00931; WBGene00008404; WP:CE00931 ViswanathanM et al 2005 S2 sir-2.1 regulated D2021.1 Aff_D2021.1 D2021.1; CE01878; WBGene00017046; WP:CE01878; XJ181 glucose repression mediator protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated D2023.4 Aff_D2023.4 D2023.4; D2023.4.1; D2023.4.2; 5M304; CE09074; WBGene00008408; WP:CE09074 D2023.4 encodes a thialysine N-(epsilon)-acetyltransferase, belonging to the GCN5-related N-acetyltransferase superfamily; recombinant D2023.4 protein forms a catalytically active homodimer, most efficiently catalysing the N-acetylation of thialysine [S-(2-aminoethyl)-L-cysteine], O-(2-aminoethyl)-L-serine and S-(2-aminoethyl)-D,L-homocysteine. diamine acetyltransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 D2023.5 Aff_D2023.5 D2023.5; 5M306; CE09075; WBGene00008409; WP:CE09075 thiosulphate sulphurtransferase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA D2024.6 Aff_D2024.6 cap-1; D2024.6; D2024.6.1; D2024.6.2; 4H994; CAPZ/A; CE04295; NM_068744; WBGene00000292; WP:CE04295 cap-1 encodes an F-actin capping protein alpha subunit that affects fertility; likely expressed in touch receptor neurons. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated D2030.1 Aff_D2030.1 D2030.1; D2030.1.1; D2030.1.2; D2030.1.3; 1I144; CE09078; WBGene00008411; WP:CE09078 alpha 1,2 mannosidase precursor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol D2030.2 Aff_D2030.2 D2030.2; D2030.2a.1; D2030.2a.2; D2030.2a.3; D2030.2a.4; D2030.2b.1; D2030.2b.2; D2030.2b.3; D2030.2b.4; D2030.2b.5; D2030.2b.6; 1I153; CE09079; CE35176; WBGene00008412; WP:CE09079; WP:CE35176 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated D2030.4 Aff_D2030.4 D2030.4; D2030.4.1; D2030.4.2; 1I156; CE09081; WBGene00008414; WP:CE09081 NADH:CoQ oxidoreductase subunit B18 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA D2030.5 Aff_D2030.5 mce-1; D2030.5; 1I159; CE09082; WBGene00008415; WP:CE09082 B.subtilis YQJC protein like ViswanathanM et al 2005 S2 sir-2.1 regulated D2030.6 Aff_D2030.6 D2030.6; D2030.6.1; D2030.6.2; 1I162; CE09083; WBGene00008416; WP:CE09083 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated D2030.8 Aff_D2030.8 D2030.8; 1I169; CE28545; WBGene00008418; WP:CE28545 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated D2045.2 Aff_D2045.2 D2045.2; 3L542; CE00639; WBGene00008422; WP:CE00639 McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated D2045.6 Aff_D2045.6 cul-1; lin-19; D2045.6; 3L563; CE29089; WBGene00000836; WP:CE29089 cul-1 encodes a cullin, orthologous to Cdc53/Cul1 in S. cerevisiae and CUL-1 in humans (OMIM:603134), that is required both maternally and zygotically for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway, and that is probably also required for normally slow G1-to-S phase progression; CUL-1 physically interacts with eight Skp1-related proteins (SKR-1, -2, -3, -4, -7, -8, -9, and -10). Cuticlin family McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan D2085.1 Aff_D2085.1 pyr-1; D2085.1; 2I947; CE03105; NM_063437; WBGene00004259; WP:CE03105 pyr-1 is orthologous to the human gene CARBAMYL PHOSPHATE SYNTHETASE I (CPS1, which when mutated leads to hyperammonemia (OMIM:237300); PYR-1 protein is predicted to be mitochondrial with 68% accuracy. glutamine-dependent carbamoyl-phosphate synthase, aspartate carbamoyltransferase, dihydroorotase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated D2085.2 Aff_D2085.2 D2085.2; 2I949; CE34785; WBGene00008427; WP:CE34785 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated D2085.4 Aff_D2085.4 D2085.4; 2I957; CE15744; WBGene00008429; WP:CE15744 similarity with a human hypothetical protein (PIR Acc. No. A38919) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated D2089.1 Aff_D2089.1 rsp-7; D2089.1; D2089.1b.1; D2089.1b.2; D2089.1b.3; 2K951; CE03111; CE30507; NM_171033; NM_171034; WBGene00004704; WP:CE03111; WP:CE30507 RNA binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes D2089.3 Aff_D2089.3 D2089.3; 2K952; CE00938; WBGene00008434; WP:CE00938 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph D2089.5 Aff_D2089.5 gbh-1; D2089.5; 2K982; CE00940; NM_063904; WBGene00001522; WP:CE00940 gbh-1 encodes a predicted ortholog of human hBBOX1; expressed in the intestine and in head and body muscles. gamma-butyrobetaine,2-oxoglutarate dioxygenase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated D2092.2 Aff_D2092.2 D2092.2; D2092.2.1; D2092.2.2; 1H202; CE09101; WBGene00017064; WP:CE09101 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated D2096.2 Aff_D2096.2 D2096.2; 4J145; CE29245; CE38496; WBGene00017070; WP:CE29245; WP:CE38496 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated D2096.8 Aff_D2096.8 D2096.8; 4J144; CE04306; WBGene00017075; WP:CE04306 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated DY3.1 Aff_DY3.1 tim-13; tin-13; DY3.1; 1J336; CE15745; NM_059969; WBGene00006574; WP:CE15745; tim13 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol DY3.2 Aff_DY3.2 lmn-1; DY3.2; DY3.2.1; DY3.2.2; 1J341; CE15746; Lam1; NM_059970; WBGene00003052; WP:CE15746 The lmn-1 gene encodes a nuclear lamin; LMN-1 protein is essential for the nuclear envelope localization of emerin (EMR-1) protein during during early development. Intermediate filament proteins (2 domains) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated DY3.4 Aff_DY3.4 trt-1; DY3.4; DY3.4a.1; DY3.4a.2; DY3.4b.1; DY3.4b.2; DY3.4b.3; DY3.4b.4; DY3.4b.5; 1J347; CE15748; CE27901; CETERT; NM_059972; NM_059973; WBGene00006618; WP:CE15748; WP:CE27901 trt-1 encodes C. elegans telomerase reverse transcriptase that affects fertility, maintenance of telomere length, and chromosome nondisjunction. Reverse transcriptase (RNA-dependent DNA polymerase) Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated DY3.7 Aff_DY3.7 sup-17; DY3.7; 1J373; CE15751; NM_059976; WBGene00006324; WP:CE15751 sup-17 encodes an ADAM protein, an integral membrane disintegrin and zinc-activated metalloproteinase, orthologous to Drosophila and mouse KUZBANIAN and the vertebrate ADAM10 proteins; SUP-17 is required maternally for embryonic development and plays a role in LIN-12/Notch-mediated cell signaling required for several cell fate decisions during vulval development; SUP-17 is also required for normal body morphology and male tail development; SUP-17 functions cell autonomously to facilitate LIN-12 signaling and requires the LIN-12 extracellular domain to do so. Zinc-binding metalloprotease domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E E01A2.2 Aff_E01A2.H E01A2.2; E01A2.2b.1; E01A2.2b.2; 1E703; CE20643; CE33369; WBGene00017085; WP:CE20643; WP:CE33369 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen E01A2.4 Aff_E01A2.D, Aff_E01A2.E, Aff_E01A2.F E01A2.4; 1E698; CE24871; WBGene00017086; WP:CE24871 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated E01G4.5 Aff_E01G4.5 E01G4.5; 2N763; CE23623; WBGene00008447; WP:CE23623 Jones et al 2001 Dauer specific genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, IVb male soma enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset E01G6.1 Aff_E01G6.1 E01G6.1; CE03112; WBGene00008449; WP:CE03112; XM883 pancreatic trypsin inhibitor (kunitz) protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 E02D9.1 Aff_C37A2.1 C37A2.1; E02D9.1; E02D9.1b.1; E02D9.1b.2; 1H379; CE08610; CE27902; CE31335; CE31336; WBGene00017098; WP:CE08610; WP:CE27902; WP:CE31335; WP:CE31336 protein kinase Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 E02H1.1 Aff_E02H1.1 E02H1.1; 2J880; CE30642; WBGene00008455; WP:CE30642 rRNA methyltransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated E02H1.2 Aff_E02H1.2 E02H1.2; 2J878; CE01537; WBGene00008456; WP:CE01537 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. GTP binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA E02H1.3 Aff_E02H1.3 tag-124; E02H1.3; CE01538; WBGene00006473; WP:CE01538 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. Yeast DEG-1 protein homolog Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated E02H1.4 Aff_E02H1.4 pme-2; E02H1.4; 2J883; CE01539; WBGene00004050; WP:CE01539 ADP-Ribosyltransferase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated E02H1.6 Aff_E02H1.6 E02H1.6; 2J887; CE28286; WBGene00008458; WP:CE28286 ATP binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated E02H4.3 Aff_E02H4.3 tag-172; E02H4.3; CE31462; CE31463; WBGene00006517; WBGene00008461; WP:CE31462; WP:CE31463 serine/threonine kinase (CLK subfamily) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol E03A3.3 Aff_E03A3.3 his-69; E03A3.3; 3F148; CE00942; NM_065410; WBGene00001943; WP:CE00942 his-69 encodes a truncated H3 histone. histone H3 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol E04A4.8 Aff_E04A4.8, Aff_Y17G9B.E rpl-20; E04A4.8; E04A4.8.1; E04A4.8.2; 4F516; CE21392; NM_068229; WBGene00004432; WP:CE21392 rpl-20 encodes a large ribosomal subunit L18a protein. ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated EEED8.1 Aff_EEED8.1 tudr-1; EEED8.1; 2F713; CE26746; NM_062627; WBGene00017132; WP:CE26746 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated EEED8.10 Aff_EEED8.10 EEED8.10; 2F686; CE39344; WBGene00017138; WP:CE39344 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Probable RNA binding protein. Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol EEED8.2 Aff_EEED8.2 EEED8.2; 2F707; CE01886; WBGene00017133; WP:CE01886 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol EEED8.4 Aff_EEED8.4 EEED8.4; 2F699; CE39716; WBGene00017135; WP:CE39716 Probable RNA binding protein EEED8.7 Aff_EEED8.7 rsp-4; srp-2; EEED8.7; 2F678; CE01891; CE27910; CeSC35; NM_062612; NM_062613; WBGene00004701; WP:CE01891; WP:CE27910 splicing factor SC35 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated EEED8.8 Aff_EEED8.8 ndx-6; EEED8.8; 2F680; CE27911; NM_062614; WBGene00003583; WP:CE27911 The ndx-6 gene encodes a NUDIX hydrolase. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated EGAP2.1 Aff_EGAP2.1 EGAP2.1; 2F523; CE35268; WBGene00017147; WP:CE35268 Jones et al 2001 Dauer specific genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F01D4.5 Aff_F01D4.5 F01D4.5; 4L248; CE29035; CE29036; WBGene00008488; WP:CE29035; WP:CE29036 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F01F1.1 Aff_F01F1.1 F01F1.1; 3G971; CE26885; CE29249; CE32351; WBGene00017158; WP:CE26885; WP:CE29249; WP:CE32351 F01F1.10 Aff_F01F1.10 F01F1.10; 3G956; CE01223; CE32851; CE33045; WBGene00017164; WP:CE01223; WP:CE32851; WP:CE33045 F01F1.10 encodes two isoforms of an endo-beta-N-acetylglucosaminidase (ENGase, or Endo-M); recombinant F01F1.10 has ENGase activity when expressed in E. coli, with specificity mainly for high-mannose type oligosaccharides, and optimal activity on Man8GlcNAc2; F01F1.10 has no obvious phenotype in mass RNAi screens; F01F1.10 is predicted to catabolize free oligosaccharides in the cytosol. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F01F1.15 Aff_F01F1.11 F01F1.15; F01F1.15.1; F01F1.15.2; 3G958; CE26884; WBGene00017169; WP:CE26884 F01F1.2 Aff_F01F1.2 F01F1.2; 3G969; CE26886; WBGene00017159; WP:CE26886 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F01F1.6 Aff_F01F1.6 alh-9; F01F1.6; F01F1.6.1; F01F1.6.2; F01F1.6.3; 3G947; CE39486; NM_065862; WBGene00000115; WP:CE39486 Aldehyde dehydrogenase Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F01F1.8 Aff_F01F1.8 cct-6; F01F1.8; F01F1.8a.1; F01F1.8a.2; F01F1.8b.1; F01F1.8b.2; F01F1.8b.3; 3G944; CE01234; CE30647; NM_171135; NM_171136; WBGene00000381; WP:CE01234; WP:CE30647 eukaryotic cytosolic chaperonin; affects viability and fertility, and is expressed in various muscle and neuronal cells: near the pharynx, near the anal sphincter, in the ventral nerve cord and the nerve ring; occasionally the expression is visible in hypodermal cells and in some vulval cells. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F01F1.9 Aff_F01F1.9 F01F1.9; 3G952; CE01235; WBGene00017163; WP:CE01235 McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F01G10.1 Aff_F01G10.1 F01G10.1; F01G10.1.1; F01G10.1.2; 4L9; CE09163; WBGene00008506; WP:CE09163 The F01G10.1 gene encodes an ortholog of the human gene TRANSKETOLASE (TKT; OMIM:606781), which when mutated leads to Wernicke-Korsakoff syndrome (OMIM:277730). transketolase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F01G10.8 Aff_F01G10.8 daf-14; F01G10.8; 4L19; CE29090; NM_069479; WBGene00000910; WP:CE29090 daf-14 encodes a Smad-related protein that is unusual in that while its C-terminus is well-conserved with Smad proteins, it lacks the N-terminal DNA binding domain found in all other known Smads; DAF-14 is predicted to function as a transducer of the DAF-7/TGF-beta-mediated signal that promotes reproductive growth and negatively regulates dauer formation; as reduction of daf-14 function enhances the dauer constitutive phenotype of daf-8 mutants, and overexpression of daf-14 can rescue daf-8 mutant animals, it is likely that the DAF-14 and DAF-8 Smad proteins function in parallel to control dauer formation; further genetic analyses suggest that DAF-14 and DAF-8 function to antagonize the activities of the DAF-3 Smad and DAF-5 Sno/Ski oncoprotein, which are required for dauer formation; a DAF-14::GFP reporter is expressed in a dynamic pattern in tissues, such as the hypodermis, intestine, and pharynx, that are remodeled during dauer development. Mouse MSMAD protein like Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F01G4.1 Aff_F01G4.1 psa-4; F01G4.1; F01G4.1.1; F01G4.1.2; 4L895; CE05553; NM_069681; WBGene00004204; WP:CE05553 The psa-4 (phasmid socket absent) gene encodes an ortholog of SWI2/SNF2, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-4 is probably required during mitosis of the T cells for asymmetric cell division. SNF2alpha like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol F01G4.5 Aff_F01G4.5 F01G4.5; 4L910; CE03130; WBGene00008504; WP:CE03130 ViswanathanM et al 2005 S2 sir-2.1 regulated F02A9.2 Aff_F02A9.2 far-1; F02A9.2; F02A9.2.1; F02A9.2.2; F02A9.2.3; 3K170; CE00133; NM_066609; WBGene00001385; WP:CE00133 far-1 encodes a fatty acid/retinol binding protein; expressed throughout development with highest expression levels in L3 stage larvae and in adult males. O. volvulus 20Kd antigenic peptide Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F02E8.1 Aff_F02E8.1 asb-2; F02E8.1; F02E8.1.1; F02E8.1.2; CE07016; NM_076369; WBGene00000207; WP:CE07016; XF89 asb-2 encodes a ATP synthase B homolog. ATP synthase B chain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C F02E8.3 Aff_F02E8.3 aps-2; F02E8.3; CE07018; NM_076366; WBGene00000157; WP:CE07018; XF77 The aps-2 gene encodes an adaptin: specifically, it encodes an ortholog of the sigma2 subunit of adaptor protein complex 2 (AP-2), which mediates endocytosis from the plasma membrane; APS-2 appears to be required for embryonic and larval development and for normal body morphology, but is not required for endocytosis of yolk protein in developing oocytes; APS-2 is expressed in nearly all cells during embryogenesis, but during larval and adult stages, expression is confined to neurons and some hypodermal cells, including vulval hypodermal cells during the fourth larval stage. Clathrin coat assembly protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F02E8.5 Aff_F02E8.5 F02E8.5; CE07020; WBGene00017178; WP:CE07020; XF78 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F02E9.1 Aff_F02E9.1 F02E9.1; 1I981; CE09183; WBGene00008528; WP:CE09183 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F02E9.10 Aff_F02E9.6 F02E9.10; F02E9.10a.1; F02E9.10a.2; F02E9.10b.1; F02E9.10b.2; 1J4; CE27119; CE38314; WBGene00008533; WP:CE27119; WP:CE38314 F02E9.4 Aff_F02E9.4 pqn-28; F02E9.4; 1I999; CE33046; NM_059883; WBGene00004117; WP:CE33046 pqn-28 encodes an ortholog of the SIN3 family of histone deacetylase subunits, which also has a glutamine/asparagine-rich domain, possibly involved in epigenetic regulation; pqn-28 has no obvious phenotype in mass RNAi screens; on the basis of its homology, PQN-28, when activated by promoter-specific transcription factors, is expected to work in conjunction with other histone deacetylase components to induce chromatin silencing; PQN-28 may also silence genes by colocating to them with the O-GlcNAc transferase homolog OGT-1. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F02E9.5 Aff_F02E9.5 F02E9.5; 1J2; CE23628; WBGene00008530; WP:CE23628 Jones et al 2001 Dauer specific genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F02E9.7 Aff_F02E9.7 F02E9.7; 1I991; CE09190; WBGene00008531; WP:CE09190 acid phosphatase Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F02H6.2 Aff_F02H6.2 F02H6.2; 4O961; CE17626; WBGene00008535; WP:CE17626 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched F07A11.2 Aff_F07A11.2 F07A11.2; F07A11.2b.1; F07A11.2b.2; F07A11.2b.3; 2L884; CE03144; CE27915; WBGene00008546; WP:CE03144; WP:CE27915 glucosamine-fructose-6-phosphate aminotransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, IVb male soma enriched genes F07A11.3 Aff_F07A11.3 npp-5; F07A11.3; 2L888; CE03145; NM_064080; WBGene00003791; WP:CE03145 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F07A11.5 Aff_F07A11.5 F07A11.5; 2L903; CE03147; WBGene00008548; WP:CE03147 ribokinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F07C3.9 Aff_F07C3.9 F07C3.9; 5J734; CE07030; WBGene00017197; WP:CE07030 Jones et al 2001 Dauer specific genes P<0.05, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F07D10.1 Aff_F07D10.1 rpl-11.2; F07D10.1; F07D10.1.1; F07D10.1.2; F07D10.1.3; CE07033; NM_076012; WBGene00004423; WP:CE07033; XC860 rpl-11.2 encodes a large ribosomal subunit L11 protein; by homology, RPL-11.2 is predicted to function in protein biosynthesis. ribosomal protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated F07E5.5 Aff_F07E5.5 F07E5.5; 2C344; CE27916; WBGene00017210; WP:CE27916 zinc-finger protein Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes F08B4.5 Aff_F08B4.5 F08B4.5; 4J448; CE29749; WBGene00017237; WP:CE29749 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F08B4.7 Aff_F08B4.7 F08B4.7; F08B4.7.1; F08B4.7.2; 4J452; CE09232; WBGene00017238; WP:CE09232 U1 small nuclear ribonucleoprotein C McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08B6.1 Aff_F08B6.F F08B6.1; F08B6.F; 1H339; CE39717; WBGene00017239; WP:CE39717 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F08B6.2 Aff_F08B6.E gpc-2; F08B6.2; F08B6.2.1; F08B6.2.2; F08B6.2.3; 1H335; CE20656; NM_059534; WBGene00001682; WP:CE20656 gpc-2 encodes one of two C. elegans heterotrimeric G protein gamma subunits; gpc-2 is required, along with its partner GPB-1, a G protein beta subunit, for proper mitotic spindle positioning and orientation during early embryonic cell divisions; to date, GPC-2 expression has been reported in electrically excitable cells (all neurons and muscles). ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08B6.3 Aff_F08B6.C F08B6.3; F08B6.C; 1H336; CE34292; WBGene00017240; WP:CE34292 EF hand protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F08C6.2 Aff_F08C6.2 F08C6.2; CCT; CE30937; CE39144; WBGene00017241; WP:CE30937; WP:CE39144; XI199 F08C6.2 encodes a lipid-activated CTP:phosphocholine cytidylyltransferase (CCT), with CCT activity in vitro; recombinant F08C6.2 enzyme is most activated by a 1:1 mixture of phosphatidylcholine:oleate vesicles; a inhibitory 21-residue segment (residues 246-266) is critical for specific activation of F08C6.2 by lipids, since deletion or mutation of this segment causes F08C6.2 to be constitutively active without its normal lipid substrate; F08C6.2 has no obvious function in mass RNAi assays. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F08C6.4 Aff_F08C6.4 sto-1; F08C6.4; CE27924; NM_076880; WBGene00006063; WP:CE27924; XI183 Erythrocyte band 7 integral membrane protein (human) Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order F08C6.6 Aff_F08C6.6 F08C6.6; CE27925; WBGene00017244; WP:CE27925; XI186 Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F08F1.5 Aff_F08F1.5 ced-8; F08F1.5; CE34294; NM_077026; WBGene00000422; WP:CE34294; XJ34 The ced-8 gene encodes a homolog of the human putative membrane transporter XK; ced-8 is required for apoptosis to occur with normal speed during embryonic development. Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E F08F1.7 Aff_F08F1.7 tag-123; F08F1.7; CE09254; WBGene00006472; WP:CE09254; XJ38 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated F08F1.8 Aff_F08F1.8 tth-1; F08F1.8; F08F1.8.1; F08F1.8.2; CE27929; NM_077029; WBGene00006649; WP:CE27929; XJ42 tth-1 encodes a thymosin beta ortholog that contains four functionally distinct thymosin beta repeats; in vitro, TTH-1 binds multiple actin monomers as well as filamentous actin suggesting that, as its homology predicts, TTH-1 plays a direct role in regulating actin polymerization and cytoskeletal organization in C. elegans; consistent with this, loss of tth-1 activity via a deletion mutation that removes upstream sequences results in animals with a dumpy morphology that are sterile as a result of maternal effect lethality associated with deformed oocytes containing abnormally distributed actin; tth-1 mRNA is present throughout development, while TTH-1 protein is detected in the adult gonad in the inside edges of the membranous structures surrounding germline nuclei, the cytoplasm and cortex of oocytes, early embryos at points of cell contact, the developing nerve ring, and then throughout the larval and adult body, with specific enrichment in the intestine and spermatheca. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08F8.2 Aff_F08F8.2 F08F8.2; 3I451; CE30649; WBGene00017268; WP:CE30649 Hydroxymethylglutaryl-coA reductase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F08G12.2 Aff_F08G12.2 F08G12.2; CE18578; WBGene00008586; WP:CE18578; XL916 WD domain, G-beta repeat (6 domains) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F08G12.3 Aff_F08G12.3 F08G12.3; CE03168; WBGene00008587; WP:CE03168; XL921 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma F08G2.3 Aff_F08G2.3 his-42; F08G2.3; 2O120; NM_064498; WBGene00001916 his-42 encodes an H3 histone. Core histones H2A, H2B, H3 and H4 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F08G2.4 Aff_F08G2.4 F08G2.4; 2O121; 2O123; CE19776; WBGene00008576; WP:CE19776 Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F08G2.8 Aff_F08G2.8 F08G2.8; 2O145; CE19780; WBGene00008579; WP:CE19780 F09B12.2 Aff_F09B12.2 F09B12.2; CE17644; WBGene00008606; WP:CE17644; XP718 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F09B9.3 Aff_F09B9.3 erd-2; F09B9.3; CE23635; ERD2; NM_077302; WBGene00001331; WP:CE23635; XK776 erd-2 encodes a protein with homology to human ER lumen protein retaining receptor 1. ER lumen protein retaining receptor McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated F09C8.2 Aff_F09C8.2 F09C8.2; F09C8.2.1; F09C8.2.2; CE03178; WBGene00008622; WP:CE03178; XQ756 F09D1.1 Aff_F09D1.1 F09D1.1; 2C865; CE20660; WBGene00017280; WP:CE20660 ubiquitin protease McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories F09E10.3 Aff_F09E10.3 dhs-25; F09E10.3; CE30939; NM_075881; WBGene00000988; WP:CE30939; XC107 dhs-25 encodes a short-chain dehydrogenase predicted to be mitochondrial. short-chain alcohol dehydrogenase ViswanathanM et al 2005 S2 sir-2.1 regulated F09E5.13 Aff_F09E5.13 agt-2; cAGT-2; F09E5.13; 2F660; CE02608; NM_062607; WBGene00000094; WP:CE02608 agt-2 encodes a paralog of the DNA repair enzyme O6-Alkylguanine DNA-alkyltransferase (AGT); AGT-2 has AGT biochemical activity and is expressed at all developmental stages. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F09E5.3 Aff_F09E5.3 F09E5.3; F09E5.3.1; F09E5.3.2; 2F665; CE02610; WBGene00017283; WP:CE02610 Deoxyribose-phosphate aldolase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F09E5.5 Aff_F09E5.5 F09E5.5; F09E5.5.1; F09E5.5.2; 2F661; CE29752; WBGene00017284; WP:CE29752 Reinke et al 2004, wt herm vs wt male enriched gen F09E5.8 Aff_F09E5.8 F09E5.8; 2F641; CE02615; WBGene00017286; WP:CE02615 Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F09E8.2 Aff_F09E8.2 F09E8.2; 4N916; CE05579; WBGene00008624; WP:CE05579 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F09F7.3 Aff_F09F7.3 F09F7.3; F09F7.3.1; F09F7.3.2; 3G653; CE30653; WBGene00017300; WP:CE30653 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F09F7.4 Aff_F09F7.4 F09F7.4; F09F7.4a.1; F09F7.4a.2; F09F7.4b.1; F09F7.4b.2; F09F7.4b.3; 3G645; CE00689; CE30654; WBGene00017301; WP:CE00689; WP:CE30654 Enoyl-CoA hydratase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F09F7.6 Aff_F09F7.6 F09F7.6; 3G640; CE01238; WBGene00017303; WP:CE01238 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F09F7.7 Aff_F09F7.7 F09F7.7; 3G644; CE30655; CE30656; WBGene00017304; WP:CE30655; WP:CE30656 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F09F7.8 Aff_F09F7.8 nspb-12; F09F7.8; 3G656; CE38594; WBGene00017305; WP:CE38594 nspb family ViswanathanM et al 2005 S2 sir-2.1 regulated F09G2.2 Aff_F09G2.2 F09G2.2; 5H677; CE37626; WBGene00017311; WP:CE37626 ViswanathanM et al 2005 S2 sir-2.1 regulated F09G2.4 Aff_F09G2.4 F09G2.4; 5H661; CE09299; WBGene00017313; WP:CE09299 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol F09G2.8 Aff_F09G2.8 F09G2.8; F09G2.8.1; F09G2.8.2; 5H670; CE09303; WBGene00017316; WP:CE09303 Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F09G2.9 Aff_F09G2.9 F09G2.9; F09G2.9.1; F09G2.9.2; 5H674; CE09304; WBGene00017317; WP:CE09304 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F09G8.3 Aff_F09G8.3 F09G8.3; 3J357; CE24890; WBGene00017319; WP:CE24890 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F10B5.1 Aff_F10B5.1 rpl-10; F10B5.1; F10B5.1.1; F10B5.1.2; 2I435; CE01543; NM_063306; WBGene00004421; WP:CE01543 rpl-10 encodes a large ribosomal subunit L10 protein required in mass RNAi assays for embryonic viability, fertility, normally rapid growth, and normal body coloration; the rpl-10 transcription unit has a nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-10 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-7, rpl-12) have protein products that are involved in translation. ribosomal protein L10 (QM protein) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F10B5.2 Aff_F10B5.2 F10B5.2; 2I437; CE01544; WBGene00008639; WP:CE01544 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Unkown F10B5.7 Aff_F10B5.7 rrf-3; F10B5.7; 2I457; CE02178; NM_063312; WBGene00004510; WP:CE02178 rrf-3 encodes an RNA-directed RNA polymerase (RdRP) homolog that inhibits somatic RNAi, and thus promotes activity of repeated genes (e.g., multicopy transgenic arrays); the effect of RRF-3 on RNAi is opposite to that of RRF-1 (which stimulates somatic RNAi), which might arise from competition by RRF-3 with RRF-1 or EGO-1 in RNAi formation; rrf-3(allele) or rrf-3(allele2) mutants are hypersensitive to somatic RNAi, and conversely suppress the activity of an integrated rol6 (su1006) transgene. Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Metabolism F10C2.2 Aff_F10C2.2 kup-1; F10C2.2; 5M514; CE09306; NM_073615; WBGene00002241; WP:CE09306; kup1 kup-1 encodes a novel protein that is conserved in C. briggsae, but contains no other known homologs; kup-1 is the upstream gene in an operon with pkc-1, which encodes two protein kinase C isoforms of the nPKC isotype; the polycistronic kup-1/pkc-1 mRNA is detected at low levels in embryos and larvae, but its expression greatly increases in adults; as loss of kup-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kup-1 in C. elegans development and/or behavior is not yet known. KUP-1 protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F10C2.4 Aff_F10C2.4 F10C2.4; 5M525; CE09308; WBGene00008645; WP:CE09308 F10C2.4 encodes a homolog of the DNA polymerase delta complex subunit A that is required in embryos for the normal timing of embryonic cell divisions (much as DIV-1 is) and, also, for normal chromosome segregation (probably because of defective DNA replication). DNA polymerase family B McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F10C2.5 Aff_F10C2.5 F10C2.5; CE09309; NM_073617; WBGene00008646; WP:CE09309 mannosyl-oligosaccharide alpha-1,2-mannosidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Romagnolo et al 2002 Fig3b Adhesion F10C2.6 Aff_F10C2.6 drs-2; F10C2.6; 5M531; CE31906; NM_073618; WBGene00001095; WP:CE31906 drs-2 encodes a putative aspartyl-tRNA synthetase. aspartyl-tRNA synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F10C5.1 Aff_Y55B1A_115.C, Aff_Y55B1B_114.A apc-8; mat-3; pod-4; vex-2; F10C5.1; F10C5.1.1; F10C5.1.2; 3B99; CE26888; NM_064802; WBGene00003134; WBGene00006909; WP:CE26888 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F10D11.1 Aff_F10D11.1 sdm-1; sod-2; F10D11.1; F10D11.1.1; F10D11.1.2; 1J11; CE09323; NM_059889; WBGene00004931; WP:CE09323 sod-2 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-2 mRNA levels are diminished by mutation of daf-16, and heterologously expressed SOD-2 in E. coli protects against methyl viologen-induced oxidative stress. superoxide dismutase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F10D11.2 Aff_F10D11.2 F10D11.2; 1J12; CE32366; WBGene00008648; WP:CE32366 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F10D7.2 Aff_F10D7.2 F10D7.2; F10D7.2.1; F10D7.2.2; CE04352; WBGene00017339; WP:CE04352; XR980 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. calcium alpha subunit; tetracycline resistance Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig3b Transporters, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F10E7.2 Aff_F10E7.2 F10E7.2; 2H415; CE35460; WBGene00017344; WP:CE35460 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma F10E7.6 Aff_F10E7.6 F10E7.6; 2H405; CE04361; WBGene00017348; WP:CE04361 F10E7.7 Aff_F10E7.7 rpl-33; F10E7.7; F10E7.7.1; F10E7.7.2; 2H397; CE04362; NM_063067; WBGene00004447; WP:CE04362 rpl-33 encodes a large ribosomal subunit L35a protein. 60s ribosomal protein L35A McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated F10E9.8 Aff_F10E9.8 dcd-1; sas-4; F10E9.8; 3J404; CE29756; NM_066427; WBGene00004726; WP:CE29756 sas-4 encodes a predicted coiled-coil protein and centriole component recruited to the centrosome once per cell cycle at the time of organelle duplication and is required for centriole duplication and spindle assembly, levels dictate centrosome size, and also affects germ cell proliferation and locomotion; colocalizes with gamma-tubulin to centrosomes both in sperm and in the syncitial part of the gonad. Lund et al 2002 Fig1 aging-regulated genes, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F10G2.4 Aff_F10G2.4 F10G2.4; 5H805; CE09332; WBGene00017365; WP:CE09332 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F10G7.1 Aff_F10G7.1 tag-151; F10G7.1; F10G7.1.1; F10G7.1.2; 2F3; CE02624; WBGene00006497; WP:CE02624 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F10G7.3 Aff_F10G7.3 asf-1; F10G7.3; F10G7.3.1; F10G7.3.2; 2E993; CE39722; WBGene00017368; WP:CE39722 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F10G7.4 Aff_F10G7.4 rad-21.1; coh-2; scc-1; F10G7.4; 2E989; CE02628; NM_062435; WBGene00004737; WP:CE02628 scc-1 encodes a member of the Rad21/Rec8-like family of cohesion proteins that affects embryonic viability, fertility, the rate of embryonic cell divisions and the incidence of male progeny; interacts with ATL-1, F56D12.5, and F11E6.1 based on yeast two-hybrid assays, and is expressed in nondividing embryonic and germline nuclei. DNA double-strand break repair Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F10G8.3 Aff_F10G8.3 npp-17; F10G8.3; F10G8.3.1; F10G8.3.2; 1K605; CE09338; CeRAE1; NM_060249; WBGene00003803; WP:CE09338 polyA RNA export protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F10G8.6 Aff_F10G8.6 F10G8.6; 1K623; CE30749; WBGene00008664; WP:CE30749 F10G8.6 encodes an homolog of S. cerevisiae CFD1 (also known as YIL003W/DRE3), a putative P-loop ATPase conserved in eukaryotes and required in yeast for 4Fe-4S cluster assembly; F10G8.6 is also homologous to yeast NBP35/YGL091C; in C. elegans, F10G8.6 is required for normally rapid growth and maintenance of the germline; F10G8.6 protein was predicted to be mitochondrial on the basis of its phylogenetic profile. nucleotide binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F10G8.9 Aff_F10G8.9 F10G8.9; 1K625; CE09344; CE30752; WBGene00008667; WP:CE09344; WP:CE30752 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F11A10.7 Aff_F11A10.2 F11A10.7; 4M851; CE28911; WBGene00008688; WP:CE28911 F11A3.2 Aff_F11A3.2 F11A3.2; 5J997; CE05586; CE38501; WBGene00008670; WP:CE05586; WP:CE38501 guanine nucleotide exchange factor Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F11A5.9 Aff_F11A5.9 F11A5.9; F11A5.9.1; F11A5.9.2; 5Q697; CE15787; WBGene00008677; WP:CE15787 sodium/phosphate transporter Kwon et al 2004 T1 late-repression Ethanol-respon, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F11C1.1 Aff_F11C1.1 F11C1.1; CE03186; WBGene00008690; WP:CE03186; XN606 Jones et al 2001 Dauer specific genes P<0.05, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F11C1.2 Aff_F11C1.2 F11C1.2; CE31472; WBGene00008691; WP:CE31472; XN604 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F11C1.5 Aff_F11C1.5 F11C1.5; CE20666; CE20667; WBGene00008694; WP:CE20666; WP:CE20667; XN617 nir like gene involved in denitrification F11E6.3 Aff_F11E6.3 F11E6.3; F11E6.3.1; F11E6.3.2; 4S414; CE19783; WBGene00008707; WP:CE19783 F11E6.7 Aff_F11E6.7 F11E6.7; 4S402; CE19787; WBGene00008710; WP:CE19787 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F11G11.5 Aff_F11G11.5 F11G11.5; CE07058; NM_062473; WBGene00017385; WP:CE07058 ViswanathanM et al 2005 S2 sir-2.1 regulated F11G11.7 Aff_F11G11.7 dnj-9; F11G11.7; 2F149; CE07060; NM_062471; WBGene00001027; WP:CE07060 This gene encodes a protein containing a DnaJ ('J') domain. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F11H8.1 Aff_F11H8.1 cyk-5; rfl-1; uba-3; F11H8.1; 3I113; CE34538; NM_066133; WBGene00004341; WP:CE34538 rfl-1 (also known as cyk-5) encodes an ortholog of UBA3, a Nedd8 activating enzyme for ubiquitin-like proteins, which is required for proper cytokinesis and spindle orientation; NED-8 is presumably activated by an ULA-1/RFL-1 heterodimer. ubiquitin-activating enzyme McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 Resveratrol regulate WT F12F6.1 Aff_F12F6.1 F12F6.1; 4M351; CE34803; WBGene00008720; WP:CE34803 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F12F6.5 Aff_F12F6.5 tag-13; F12F6.5; 4M341; CE20680; WBGene00006406; WP:CE20680 chimaerin like Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E F12F6.6 Aff_F12F6.6 sec-24.1; F12F6.6; 4M328; CE05594; NM_069777; WBGene00004755; WP:CE05594 sec-24.1 encodes one of two C. elegans Sec24 homologs; in Saccharomyces cerevisiae, Sec24 is a member of the Sec24-Sec23 subunit of the COPII coat complex, assembly of which is essential for the first step of secretory protein transport from the endoplasmic reticulum (ER) to the Golgi; by homology with Sec24, SEC-24.1 is predicted to facilitate vesicle cargo selection, and likely contains multiple, independent sites for binding to secreted proteins; loss of sec-24.1 activity via RNAi indicates that SEC-24.1 is required for cuticle secretion and oogenesis. Yeast hypothetical YIK9 protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F13B10.2 Aff_F13B10.2 rpl-3; F13B10.2; F13B10.2a.1; F13B10.2a.2; F13B10.2d.1; F13B10.2d.2; 3E959; CE05598; CE36996; CE36997; NM_065382; WBGene00004414; WP:CE05598; WP:CE36996; WP:CE36997 rpl-3 encodes a large ribosomal subunit L3 protein required in mass RNAi assays for embryonic and larval viability, fertility, and general health; the rpl-3 transcription unit has a nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-3 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-7, rpl-10, rpl-12) have protein products that are involved in translation. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F13B12.1 Aff_F13B12.1 F13B12.1; F13B12.1.1; F13B12.1.2; 4L188; CE05599; WBGene00008729; WP:CE05599 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F13B9.1 Aff_F13B9.1 F13B9.1; CE30949; CE35469; CE37100; WBGene00017419; WP:CE30949; WP:CE35469; WP:CE37100; XI911 F13B9.1 encodes two proteins by alternative splicing which contain both an immunoglobulin/MHC-like domain and a glutamine/asparagine-rich domain. ViswanathanM et al 2005 S2 sir-2.1 regulated F13B9.5 Aff_F13B9.4 ksr-1; sar-2; sur-3; F13B9.5; F13B9.5.1; F13B9.5.2; CE25854; NM_076995; WBGene00002239; WP:CE25854; XI901 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F13D12.2 Aff_F13D12.2 ldh-1; F13D12.2; 2M15; CE02181; LDH; NM_064102; WBGene00002262; WP:CE02181 ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency. L-lactate dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F13D12.4 Aff_F13D12.4 alh-8; F13D12.4; F13D12.4a.1; F13D12.4a.2; F13D12.4a.3; F13D12.4a.4; 2M21; CE02183; CE36262; WBGene00000114; WP:CE02183; WP:CE36262 alh-8 is orthologous to the human gene METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (ALDH6A1; OMIM:603178), which when mutated leads to MMSDH deficiency. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F13E6.1 Aff_F13E6.1 F13E6.1; CE31474; WBGene00008745; WP:CE31474; XL294 D52 protein Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F13E6.5 Aff_F13E6.5 F13E6.5; CE37502; WBGene00008749; WP:CE37502; XL315 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F13G3.10 Aff_F13G3.10 F13G3.10; CE17660; NM_059669; WBGene00008768; WP:CE17660 ViswanathanM et al 2005 S2 sir-2.1 regulated F13G3.11 Aff_F13G3.7 F13G3.11; F13G3.11.1; F13G3.11.2; 1H885; CE28913; WBGene00008769; WP:CE28913 F13G3.4 Aff_F13G3.4 dylt-1; F13G3.4; 1H876; CE17659; NM_059662; WBGene00008764; WP:CE17659 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated F13G3.5 Aff_F13G3.5 F13G3.5; F13G3.5.1; F13G3.5.2; 1H878; CE29761; WBGene00008765; WP:CE29761 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. myo-inositol-1-monophosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F13G3.6 Aff_F13G3.6 F13G3.6; 1H880; CE05618; WBGene00008766; WP:CE05618 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. B.subtilis teichoic acids biosynthesis protein GGAB like Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F13G3.9 Aff_F13G3.9 mif-3; F13G3.9; 1H890; CE09371; NM_059668; WBGene00003236; WP:CE09371 macrophage migratory inhibitory factor MIF like Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F13H10.2 Aff_F13H10.2 ndx-9; F13H10.2; 4L776; CE35474; NM_069650; WBGene00003586; WP:CE35474 The ndx-9 gene encodes a member of the NADH pyrophosphatase subfamily of the NUDIX hydrolases. NADH pyrophosphatase ViswanathanM et al 2005 S2 sir-2.1 regulated F13H10.3 Aff_F13H10.3 F13H10.3; 4L778; CE27959; CE30342; WBGene00008774; WP:CE27959; WP:CE30342 Yeast YEH4 like protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F13H10.4 Aff_F13H10.4 F13H10.4; 4L782; CE05625; WBGene00008775; WP:CE05625 F13H10.4 is orthologous to the human gene A-GLUCOSIDASE I (GCS1; OMIM:601336), which when mutated leads to disease. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F13H8.7 Aff_F13H8.7 F13H8.7; F13H8.7.1; F13H8.7.2; F13H8.7.3; 2G578; CE02641; WBGene00017440; WP:CE02641 beta-ureidopropionase (rat) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F14D12.2 Aff_F14D12.2 unc-97; F14D12.2; CE04392; NM_076542; WBGene00006826; WP:CE04392; XG213 The unc-97 gene encodes a LIM domain-containing protein of the PINCH family that is highly similar to human LIMS1 (OMIM:602567) and LIMS2; UNC-97 functions as an adaptor protein important for assembly of muscle adherens junctions and the mechanosensory functions of the touch neurons; UNC-97 interacts with PAT-4/integrin-linked kinase and with UNC-98; UNC-97 colocalizes with PAT-3/beta integrin at dense bodies, focal adhesion-like muscle attachment structures. LIM domain containing protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order F14E5.2 Aff_F14E5.2 F14E5.2; 2I714; CE03205; CE36926; WBGene00008800; WP:CE03205; WP:CE36926 cysteine-rich fibroblast growth factor receptor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F14F3.2 Aff_F14F3.2 F14F3.2; CE31478; WBGene00008805; WP:CE31478; XL145 ankyrin motif McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F14F4.3 Aff_F14F4.3 mrp-5; F14F4.3; CE23649; CE23650; NM_078077; NM_078078; WBGene00003411; WP:CE23649; WP:CE23650; XP558 The mrp-5 gene encodes a homolog of the human gene CFTR, which when mutated leads to cystic fibrosis (OMIM:219700). F14H12.4 Aff_F14H12.4 F14H12.4; CE39916; CE39917; WBGene00017472; WP:CE39916; WP:CE39917; XE961 protein kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F14H3.3 Aff_F14H3.3 F14H3.3; 5Q532; CE23651; WBGene00008822; WP:CE23651 Golden et al 2004, daf-2 differentially expressed , Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F14H8.1 Aff_F14H8.1 obr-2; F14H8.1; 5P492; CE35859; NM_074294; WBGene00008832; WP:CE35859 oxysterol-binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes F15B10.2 Aff_F15B10.2 drh-1; F15B10.2; F15B10.2.1; F15B10.2.2; 4H372; CE16988; NM_068617; WBGene00001090; WP:CE16988 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Reinke et al 2004, wt herm vs wt male enriched gen F15B10.3 Aff_F15B10.3 F15B10.3; 4H369; CE16989; WBGene00017481; WP:CE16989 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F15B9.4 Aff_F15B9.4 F15B9.4; 5N485; CE37351; WBGene00008848; WP:CE37351 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F15C11.2 Aff_F15C11.2 F15C11.2; 1H603; CE09413; CE31479; CE31480; WBGene00008852; WP:CE09413; WP:CE31479; WP:CE31480 Ubiquitin family McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F16A11.1 Aff_F16A11.1 F16A11.1; 1J970; CE17679; WBGene00008876; WP:CE17679 Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F16B12.6 Aff_F16B12.6 F16B12.6; CE32383; WBGene00008882; WP:CE32383; XO725 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F16B4.8 Aff_F16B4.8 cdc-25.2; F16B4.8; 5C63; CE19796; NM_071045; WBGene00000387; WP:CE19796 cdc-25.2 encodes a putative homolog of Cdc25 phosphatase protein family that affects germline proliferation. protein-tyrosine phosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol F16D3.2 Aff_F16D3.2 rsd-6; F16D3.2; F16D3.2.1; F16D3.2.2; F16D3.2.3; 1I936; CE32384; NM_059868; WBGene00004684; WP:CE32384 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F16D3.4 Aff_F16D3.4 F16D3.4; 1I940; CE09437; WBGene00008887; WP:CE09437 F16D3.4 encodes an ortholog of human TUBULIN-SPECIFIC CHAPERONE D (TBCD; OMIM:604649), also known as tubulin-folding cofactor D; F16D3.4 may be a ligand and effector of the ARL2 ortholog EVL-20. Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F17A2.13 Aff_F17A2.13 F17A2.13; CE33999; WBGene00008904; WP:CE33999; XM941 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F17A2.5 Aff_F17A2.5 ceh-40; F17A2.5; CE03215; NM_077659; WBGene00000461; WP:CE03215; XM934 a homeodomain protein homologous to Extradenticle (Exd) from Drosophila, genetically interacts with ceh-20. Homeobox domain Reinke et al 2004, wt herm vs wt male enriched gen F17A9.2 Aff_F17A9.2 F17A9.2; 5G593; CE19798; WBGene00017534; WP:CE19798 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F17A9.4 Aff_F17A9.4 F17A9.4; 5G590; CE09448; WBGene00017536; WP:CE09448 McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F17A9.6 Aff_F17A9.6 ceh-49; F17A9.6; 5G600; CE27970; WBGene00017538; WP:CE27970 F17A9.6 encodes a divergent ONECUT class CUT homeobox protein with a single N-terminal cut domain; F17A9.6 has an atypical tyrosine residue at position 48 of its homeodomain rather than a phenylalanine or tryptophan residue; the cut domain may be a compact DNA-binding domain composed of alpha helices; phylogenetically, F17A9.6 is (somewhat distantly) affiliated with C17H12.9, Drosophila ONECUT, and mammalian HNF6 proteins; F17A9.6 has no obvious function in mass RNAi assays. homeobox protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F17C11.4 Aff_F17C11.4 F17C11.4; 5L433; CE05651; WBGene00008915; WP:CE05651 Jones et al 2001 Dauer specific genes P<0.05, Jones et al 2001 T3 20 most abundant Dauer, Lund et al 2002 Fig4 Mount 15, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F17C11.7 Aff_F17C11.7 F17C11.7; 5L438; CE05654; CE37354; WBGene00008918; WP:CE05654; WP:CE37354 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F17C11.8 Aff_F17C11.8 tag-318; F17C11.8; F17C11.8.1; F17C11.8.2; 5L440; CE38502; WBGene00008919; WP:CE38502 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F17E9.10 Aff_F17E9.10 his-32; F17E9.10; 4J99; NM_069006; WBGene00001906 his-32 encodes an H3 histone; by homology, HIS-32 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-32 is a replication-dependent histone locus that resides in the HIS5 cluster on chromosome IV. histone H3 F17E9.12 Aff_F17E9.12 his-31; F17E9.12; 4J96; NM_069005; WBGene00001905 his-31 encodes an H4 histone; his-31 is contained within the histone gene cluster HIS5. ViswanathanM et al 2005 S2 sir-2.1 regulated F17H10.1 Aff_F17H10.1 F17H10.1; CE03226; WBGene00008925; WP:CE03226; XN725 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F17H10.3 Aff_F17H10.3 F17H10.3; CE31483; WBGene00008927; WP:CE31483; XN732 PhoX homologous domain, present in p47phox and p40phox. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F18A1.2 Aff_F18A1.2 lin-26; F18A1.2; F18A1.2.1; F18A1.2.2; F18A1.2.3; 2H973; CE27972; WBGene00003012; WP:CE27972 lin-26 encodes a putative C2H2 zinc finger-containing protein required for proper differentiation of ectodermal and mesodermal epithelial cells; LIN-26 is expressed in many different cell types including the rectal rep cells, the somatic gonad, glial cells, and hypodermal cells; ectopic LIN-26 expression during embryogenesis induces epithelial-like cell fates suggesting that LIN-26 is sufficient for epithelial differentiation. transcription factor Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F18A1.4 Aff_F18A1.4 lir-2; F18A1.4; 2H961; CE27975; CE27976; WBGene00003045; WP:CE27975; WP:CE27976 contains C2H2-type zinc finger Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F18A1.5 Aff_F18A1.5 F18A1.5; F18A1.5.1; F18A1.5.2; 2H955; CE04405; WBGene00017546; WP:CE04405 F18A1.5 encodes the C. elegans ortholog of the replication protein A (RPA) large subunit; by homology, the F18A1.5 gene product is predicted to function as a DNA binding and oligonucleotide oligosaccharide binding (OB) protein that is required for DNA replication, repair, and recombination; large-scale RNAi screens indicate that the product of F18A1.5 is essential for embryonic development, and that in yeast two-hybrid assays interacts with the product of M04F3.1, the RPA medium subunit; in situ hybridization studies indicate that F18A1.5 transcripts are expressed in germ cells. replication factor A McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F18A11.3 Aff_F18A11.3 F18A11.3; 2N326; CE09453; WBGene00008930; WP:CE09453 ViswanathanM et al 2005 S2 sir-2.1 regulated F18C5.3 Aff_F18C5.3 tag-184; F18C5.3; 2G843; CE02652; WBGene00007050; WBGene00017558; WP:CE02652 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F18E2.3 Aff_F18E2.3 scc-3; F18E2.3; 5N247; CE05664; NM_073792; WBGene00004738; WP:CE05664 scc-3 encodes a cohesin complex subunit homologous to Saccharomyces cerevisiae Irr1p/Scc3p; SCC-3 is required during meiosis for synaptonemal complex formation and sister chromatid cohesion, proper localization of REC-8 to chromosomes, mitotic chromosome segregation, embryonic development, and vulval morphogenesis; in embryos, SCC-3 forms a cohesin complex with SCC-1, SMC-1, SMC-3, and TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS; in the germline, SCC-3 associates with chromatin of transistion zone nuclei, assembles along the longitudinal axes of synapsed chromosomes at pachytene, and unlike other cohesins, localizes throughout chromatin at diakinesis; SCC-3 localization requires TIM-1, and SCC-3 and REC-8 are mutually required for chromatin localization. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F18H3.1 Aff_F18H3.1 F18H3.1; CE37505; WBGene00008939; WP:CE37505; XO139 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F19B10.1 Aff_F19B10.1 F19B10.1; 2D975; CE09468; WBGene00017583; WP:CE09468 ViswanathanM et al 2005 S2 sir-2.1 regulated F19B10.9 Aff_F19B10.9 sea-1; tbx-18; F19B10.9; CE09476; WBGene00004750; WP:CE09476 Jiang et al 2001 Fig1 hermaphrodite-enriched TF, Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, Romagnolo et al 2002 Fig3b TF, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F19B6.1 Aff_F19B6.1 F19B6.1; CE05666; CE20700; NM_069949; NM_069950; WBGene00008948; WP:CE05666; WP:CE20700 uridine kinase Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F19F10.10 Aff_F19F10.10 F19F10.10; 5I58; CE09490; WBGene00017606; WP:CE09490 Jones et al 2001 Dauer specific genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F19F10.9 Aff_F19F10.9 F19F10.9; 5I52; CE27372; WBGene00017605; WP:CE27372 The F19F10.9 gene encodes a homolog of the human SART1 gene, which encodes a protein recognised by IgE that may be involved in atopic disease. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F20A1.1 Aff_F20A1.1 F20A1.1; 5H533; CE07091; WBGene00017613; WP:CE07091 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order F20B6.2 Aff_F20B6.2 vha-12; F20B6.2; F20B6.2.1; F20B6.2.2; CE04424; NM_076310; WBGene00006921; WP:CE04424; XE811 vacuolar ATP synthase (strong) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F20B6.7 Aff_F20B6.7 F20B6.7; CE04429; WBGene00017631; WP:CE04429; XE826 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F20B6.8 Aff_F20B6.8 hpk-1; F20B6.8; F20B6.8c.1; F20B6.8c.2; F20B6.8c.3; F20B6.8c.4; F20B6.8c.5; CE04430; CE30961; CE30962; NM_171662; NM_171663; NM_171664; WBGene00001994; WP:CE04430; WP:CE30961; WP:CE30962; XE830 hpk-1 encodes a predicted dual-specificity protein kinase with distant homology to the vertebrate protein kinase DYRK1A and the Drosophila homolog mini-brain; increased expression of DYRK1A is implicated in the neuropathology of trisomy 21/Down syndrome; RNA interference of hpk-1 does not result in any detectable phenotype; the HPK-1::GFP fusion protein is localized to the nucleus and is expressed in cleavage stage embryos. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol F20D1.1 Aff_F20D1.1 F20D1.1; F20D1.1.1; F20D1.1.2; CE09494; WBGene00008973; WP:CE09494; XP588 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F20D1.3 Aff_F20D1.3 F20D1.3; F20D1.3.1; F20D1.3.2; CE31486; WBGene00008975; WP:CE31486; XP595 F20D1.4 Aff_F20D1.4 F20D1.4; CE09497; WBGene00008976; WP:CE09497; XP602 transcriptional activator protein PUR-alpha like Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F20G2.2 Aff_F20G2.2 F20G2.2; 5O234; CE09505; WBGene00008986; WP:CE09505 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F20G4.1 Aff_F20G4.1 F20G4.1; 1I496; CE34296; WBGene00008990; WP:CE34296 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol F20H11.1 Aff_F20H11.1 F20H11.1; 3H680; CE29769; WBGene00017646; WP:CE29769 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F21A10.2 Aff_F21A10.2 F21A10.2; F21A10.2a.1; F21A10.2a.2; F21A10.2a.3; F21A10.2a.4; CE23678; CE31488; CE31489; WBGene00008999; WP:CE23678; WP:CE31488; WP:CE31489; XK800 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order F21C10.10 Aff_F21C10.10 F21C10.10; F21C10.10.1; F21C10.10.2; 5J577; CE30758; WBGene00017659; WP:CE30758 Kwon et al 2004 T1 late-repression Ethanol-respon, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F21C3.5 Aff_F21C3.5 F21C3.5; 1H860; CE05680; WBGene00009004; WP:CE05680 Mouse KE2 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F21D5.2 Aff_F21D5.2 F21D5.2; F21D5.2.1; F21D5.2.2; 4J493; CE03245; WBGene00009007; WP:CE03245 Yeast YHB3-like protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F21D5.6 Aff_F21D5.6 F21D5.6; 4J506; CE03249; WBGene00009011; WP:CE03249 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F21D5.8 Aff_F21D5.8 F21D5.8; 4J504; CE03250; WBGene00009013; WP:CE03250 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F21F3.6 Aff_F21F3.6 F21F3.6; F21F3.6.1; F21F3.6.2; 1F480; CE09536; WBGene00017675; WP:CE09536 Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F21G4.2 Aff_F21G4.2 mrp-4; F21G4.2; CE09548; NM_077257; WBGene00003410; WP:CE09548; XK507 The mrp-4 gene encodes a homolog of human CFTR, which when mutated leads to cystic fibrosis (OMIM:219700). multidrug resistance-associated protein Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F21H11.2 Aff_F21H11.1 sax-2; F21H11.2; 3G219; CE38067; CE38068; NM_171117; NM_171118; WBGene00004728; WBGene00017682; WP:CE38067; WP:CE38068 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT F21H11.3 Aff_F21H11.3 sdf-13; tbx-2; F21H11.3; F21H11.3.1; F21H11.3.2; 3G222; CE01245; NM_065687; WBGene00006543; WP:CE01245 tbx-2 encodes one of 21 C. elegans T-box transcription factors; during development, tbx-2 activity is required for normal adaptation, but not chemotaxis, to attractive odorants sensed by the AWC amphid neurons; tbx-2 is also required redundantly with unc-3 and unc-31 for negative regulation of dauer formation, and large-scale RNAi screens reveal an essential role for tbx-2 in early larval development, normal rates of postembryonic growth, and locomotory behavior; antibodies to TBX-2 detect expression in the cytoplasm of amphid and pharyngeal neurons in larvae and adults, suggesting that TBX-2 function may be controlled, in part, by regulation of its subcellular localization; in addition, in situ hybridization studies indicate that tbx-2 mRNA is expressed during mid-embryogenesis; tbx-2 expression in the AWC amphid neurons is sufficient to rescue the olfactory adaptation defects seen in tbx-2 mutant animals. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F22B3.2 Aff_F22B3.2 his-63; F22B3.2; 4M170; NM_069752; WBGene00001937 his-63 encodes an H3 histone; by homology, HIS-63 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-63 is a replication-dependent histone locus. histone H3 Jones et al 2001 Non dauer genes P<0.05 F22B5.2 Aff_F22B5.2 eif-3.G; F22B5.2; 2I733; CE02197; NM_063377; WBGene00001230; WP:CE02197 eif-3.G encodes a homolog of eukaryotic translation initiation factor 3, subunit 4 that affects embryonic viability, fertility, and growth. RNA binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F22B5.7 Aff_F22B5.8 zyg-9; F22B5.7; F22B5.8; 2I753; CE20707; NM_063383; WBGene00006994; WP:CE20707 zyg-9 encodes a predicted microtubule-association protein (MAP) of the XMAP215 family; during early embryonic development, maternal zyg-9 activity is required for microtubule-dependent processes such as meiotic and mitotic spindle organization and pronuclear migration; further, zyg-9 is essential for formation of long astral microtubules; ZYG-9 is required for centrosomal localization of TAC-1, the sole C. elegans TACC family member, with which it interacts, and mutually stabilizes, in vivo; in early embryos, ZYG-9 localizes to the meiotic spindle and spindle poles, as well as to mitotic centrosomes; during metaphase and anaphase ZYG-9 localizes to the central spindle region, and during interphase ZYG-9 is cytoplasmic; proper localization of ZYG-9 to the meiotic spindle is dependent upon wild-type activity of MEI-1, an ATPase essential for meiotic spindle formation, while proper localization of ZYG-9 to centrosomes is dependent, at least in part, upon TAC-1. elongation factor McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order F22B5.9 Aff_F22B5.9 frs-2; F22B5.9; 2I755; CE20708; WBGene00001498; WP:CE20708 phenylalanyl-tRNA synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F22B8.7 Aff_F22B8.7 F22B8.7; 5Q577; CE37509; WBGene00009049; WP:CE37509 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F22D3.2 Aff_F22D3.2 F22D3.2; 2H237; CE27138; CE37006; CE37762; WBGene00017699; WP:CE27138; WP:CE37006; WP:CE37762 ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F22D6.4 Aff_F22D6.4 F22D6.4; F22D6.4.1; F22D6.4.2; 1H669; CE05685; WBGene00009051; WP:CE05685 NADH_ubiquinone oxidoreductase subunit McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F22D6.5 Aff_F22D6.5 prp-4; F22D6.5; 1H668; CE05686; NM_059607; WBGene00004186; WP:CE05686 serine/threonine kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F22D6.7 Aff_F22D6.7 F22D6.7; 1H676; CE05688; WBGene00009053; WP:CE05688 F22F1.1 Aff_F22F1.1 hil-3; F22F1.1; H1.3; CE04443; NM_076974; WBGene00001854; WP:CE04443; XI779 histone h1 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes F22F4.2 Aff_F22F4.2 inx-3; opu-3; F22F4.2; F22F4.2.1; F22F4.2.2; CE33055; NM_076601; WBGene00002125; WP:CE33055; XG615 unc-7-like protein Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F22F7.1 Aff_F22F7.1 F22F7.1; F22F7.1a.1; F22F7.1a.2; 5C603; CE17691; CE32871; WBGene00017719; WP:CE17691; WP:CE32871 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F23A7.4 Aff_F23A7.4 F23A7.4; CE09578; WBGene00009069; WP:CE09578; XQ825 glutamate receptor epsilon subunit like ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F23B12.6 Aff_F23B12.6 tag-114; F23B12.6; F23B12.6.1; F23B12.6.2; 5O929; CE09598; WBGene00006465; WBGene00009083; WP:CE09598 protein farnesyltransferase beta subunit McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F23B12.8 Aff_F23B12.8 bmk-1; klp-14; F23B12.8; F23B12.8.1; F23B12.8.2; 5O934; CE09600; NM_074181; WBGene00000257; WP:CE09600 a homolog of BimC kinesin; affects embryogenesis, spindle and chromosome positioning during early embryogenesis, and genetically interacts with air-2. kinesin-like protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated F23B2.6 Aff_F23B2.6 aly-2; ref-2; F23B2.6; 4J913; CE09586; NM_069193; WBGene00000121; WP:CE09586 vimentin like Kwon et al 2004 T1 late-induction Ethanol-response, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F23C8.4 Aff_F23C8.K ubxn-1; F23C8.4; F23C8.K; 1D3; CE20713; WBGene00017733; WP:CE20713 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F23C8.5 Aff_F23C8.G F23C8.5; F23C8.5.1; F23C8.5.2; F23C8.G; 1C986; CE29774; WBGene00017734; WP:CE29774 The F23C8.5 gene encodes an ortholog of the human gene ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT (ETFB), which when mutated leads to glutaricaciduria type IIB (OMIM:130410). electron transfer flavoprotein beta McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F23C8.6 Aff_F23C8.F phi-24; F23C8.6; F23C8.F; 1C988; CE20715; WBGene00017735; WP:CE20715 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F23D12.4 Aff_F23D12.4 F23D12.4; CE05702; WBGene00009088; WP:CE05702; XP63 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F23F1.3 Aff_F23F1.3 F23F1.3; 2A323; CE31795; WBGene00017744; WP:CE31795 ViswanathanM et al 2005 S2 sir-2.1 regulated F23H11.1 Aff_F23H11.1 bra-2; tag-285; F23H11.1; 3B529; CE09609; NM_064891; WBGene00017757; WP:CE09609 The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F23H11.2 Aff_F23H11.2 F23H11.2; 3B517; CE34542; WBGene00017758; WP:CE34542 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F23H11.5 Aff_F23H11.5 F23H11.5; F23H11.5.1; F23H11.5.2; F23H11.5.3; 3B528; CE09613; WBGene00000263; WP:CE09613 The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway. ViswanathanM et al 2005 S2 sir-2.1 regulated F23H12.2 Aff_F23H12.2 F23H12.2; F23H12.2.1; F23H12.2.2; 5M822; CE05705; WBGene00009092; WP:CE05705 mitochondrial precursor receptor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F23H12.4 Aff_F23H12.4 col-1; dpy-15; sqt-3; F23H12.4; F23H12.4.1; F23H12.4.2; 5M833; CE05707; NM_073694; WBGene00005018; WP:CE05707 collagen Baugh et al 2005, PAL-1 target genes, Golden et al 2004, daf-2 differentially expressed , Golden et al 2004, N2 vs daf-2 different genes at , ReichertK et al 2005 T2 xenobiotic induced Collag, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 Resveratrol regulate WT, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 LateList F25B3.6 Aff_F25B3.6 F25B3.6; 5K60; CE09619; WBGene00009103; WP:CE09619 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F25B4.1 Aff_F25B4.1 F25B4.1; F25B4.1.1; F25B4.1.2; 5G193; CE09620; WBGene00017765; WP:CE09620 F25B4.1 is orthologous to the human gene GLYCINE CLEAVAGE SYSTEM T-PROTEIN (AMT; OMIM:238310), which when mutated leads to glycine encephalopathy. aminomethytransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 F25B4.2 Aff_F25B4.2 F25B4.2; 5G191; CE30760; PELLINO; WBGene00017766; WP:CE30760 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F25B4.4 Aff_F25B4.4 F25B4.4; 5G165; CE09622; WBGene00017767; WP:CE09622 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F25B4.5 Aff_F25B4.5 F25B4.5; F25B4.5.1; F25B4.5.2; 5G160; CE28000; WBGene00017768; WP:CE28000 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F25B5.2 Aff_F25B5.2 F25B5.2; F25B5.2.1; F25B5.2.2; 3H51; CE01919; WBGene00017774; WP:CE01919 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F25B5.5 Aff_F25B5.5 F25B5.5; 3H34; CE01922; WBGene00017776; WP:CE01922 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F25B5.6 Aff_F25B5.6 F25B5.6; F25B5.6c.1; F25B5.6c.2; 3H36; CE01923; CE29283; CE37764; WBGene00017777; WP:CE01923; WP:CE29283; WP:CE37764 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F25B5.7 Aff_F25B5.7 F25B5.7; 3H44; CE01924; CE29284; CE29285; CE32391; WBGene00017778; WP:CE01924; WP:CE29284; WP:CE29285; WP:CE32391 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F25E2.5 Aff_F25E2.5 daf-3; F25E2.5; CE26364; CE28002; CE30963; NM_075760; WBGene00000899; WP:CE26364; WP:CE28002; WP:CE30963; XB438 daf-3 encodes a Smad protein; DAF-3 functions as a transcriptional regulator that is required for formation of the alternative dauer larval stage; DAF-3 activity is antagonized by signaling through the DAF-7/TGF-beta pathway which promotes reproductive growth; in yeast two-hybrid studies, DAF-3 interacts with SMA-3, another Smad protein that does not appear to have a role in dauer formation; a DAF-3::GFP fusion protein is expressed in many tissues that undergo remodeling during dauer development; DAF-3 localizes predominantly to the cytoplasm, but is also found associated with chromosomes in mitotic cells. Jones et al 2001 T2 lifespan and Dauer, ViswanathanM et al 2005 S2 daf-16 Resveratrol F25E5.1 Aff_F25E5.1 F25E5.1; 5H951; CE07135; WBGene00017782; WP:CE07135 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F25F2.2 Aff_F25F2.2 cdh-4; F25F2.2; 3F625; CE00961; NM_065516; WBGene00000396; WP:CE00961 A homolog of a member of the cadherin superfamily that is involved in cell-cell adhesion. Approximately 25 cadherin-repeats, 3 EGF domains and one Laminin G domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol F25G6.8 Aff_F25G6.8 F25G6.8; F25G6.8.1; F25G6.8.2; 5J44; CE09644; WBGene00017799; WP:CE09644 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F25H2.10 Aff_F25H2.10 rpa-0; F25H2.10; F25H2.10.1; F25H2.10.2; 1L145; CE09655; NM_060365; WBGene00004408; WP:CE09655 rpa-0 encodes an acidic ribosomal subunit protein P0. deoxyribonuclease McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F25H2.12 Aff_F25H2.12 F25H2.12; 1L149; CE09657; CE32637; WBGene00009123; WP:CE09657; WP:CE32637 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F25H2.13 Aff_F25H2.13 F25H2.13; 1L153; CE15894; WBGene00009124; WP:CE15894 DEAH-type helicase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol F25H2.2 Aff_F25H2.2 F25H2.2; 1L121; CE09647; WBGene00009116; WP:CE09647 Phosphatase/kinase domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F25H2.4 Aff_F25H2.4 F25H2.4; 1L129; CE09649; WBGene00009118; WP:CE09649 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F25H2.8 Aff_F25H2.8 ubc-25; F25H2.8; F25H2.8.1; F25H2.8.2; 1L139; CE34543; NM_060363; WBGene00006720; WP:CE34543 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F25H5.5 Aff_F25H5.5 F25H5.5; 1J736; CE15901; WBGene00009127; WP:CE15901 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol F25H5.6 Aff_F25H5.6 F25H5.6; F25H5.6.1; F25H5.6.2; 1J734; CE29591; WBGene00009128; WP:CE29591 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F25H8.1 Aff_F25H8.1 F25H8.1; 4K696; CE05727; WBGene00009131; WP:CE05727 Yeast protein 00926 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F25H9.6 Aff_F25H9.6 F25H9.6; 5N948; CE09663; WBGene00009138; WP:CE09663 Yeast hypothetical 65.2 KD protein like McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F26A1.1 Aff_F26A1.1 F26A1.1; 3F941; CE27757; WBGene00017801; WP:CE27757 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F26A3.2 Aff_F26A3.2 F26A3.2; 1I218; CE09667; WBGene00009141; WP:CE09667 Cap binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F26A3.7 Aff_F26A3.7 F26A3.7; 1I250; CE09672; WBGene00009145; WP:CE09672 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F26A3.8 Aff_F26A3.3 rrf-1; F26A3.8; 1I220; CE27141; NM_059730; WBGene00004508; WP:CE27141 rrf-1 encodes an RNA-directed RNA polymerase (RdRP) homolog required for somatic (but not germline) RNAi; RRF-1 is also required for 'transitive interference'. F26B1.2 Aff_F26B1.2 F26B1.2; F26B1.2c.1; F26B1.2c.2; F26B1.2c.3; 1G895; CE09674; CE33057; CE33058; CE33059; CE33060; WBGene00017816; WP:CE09674; WP:CE33057; WP:CE33058; WP:CE33059; WP:CE33060 RNA-binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F26D10.12 Aff_F26D10.12 F26D10.12; 4S221; CE19812; WBGene00009156; WP:CE19812 Lectin C-type domain Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E F26D10.3 Aff_F26D10.3 hsp-1; F26D10.3; F26D10.3.1; F26D10.3.2; F26D10.3.3; T28F3.2; 4S223; CE09682; NM_070667; WBGene00002005; WP:CE09682 hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity. HSP-1 heat shock 70kd protein A Custodia et al 2001 T2 heat shock, Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated F26D11.11 Aff_F26D11.11 let-413; F26D11.11; 5I454; CE29778; CE37008; NM_072650; WBGene00002632; WP:CE29778; WP:CE37008 let-413 encodes a protein with strong similarity to human ERBIN, rat DENSIN, Drosophila SCRIB and its human ortholog hSCRIB; LET-413 protein is localized to the basolateral region of epithelial cells, and is required for the assembly of adherens junctions. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F26E4.1 Aff_F26E4.1 sur-6; F26E4.1; 1K333; CE09685; NM_060190; WBGene00006352; WP:CE09685 protein phosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F26E4.10 Aff_F26E4.13 CE-DROSHA; drsh-1; F26E4.10; 1K358; CE29039; NM_060198; WBGene00009163; WP:CE29039 drsh-1 encodes a predicted RNase III-type ribonuclease that is orthologous to Drosophila and human Drosha; by homology, DRSH-1 is predicted to function as an endoribonuclease that, in the nucleus, initiates cleavage of primary miRNA transcripts (pri-mRNAs) into pre-miRNAs that are then exported to the cytoplasm for further processing; loss of drsh-1 activity via RNAi results in re-expression of a let-7-silenced reporter in adults, suggesting that DRSH-1 is required for let-7 processing; in addition, DRSH-1 also appears to be required for fertility, as adults lacking drsh-1 activity are sterile; along with PASH-1, a double-stranded RNA binding protein, DRSH-1 may be part of a conserved multiprotein complex that regulates nuclear pri-miRNA splicing. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol F26E4.12 Aff_F26E4.12 F26E4.12; 1K359; CE09696; WBGene00009165; WP:CE09696 glutathione peroxidase Jones et al 2001 T2 lifespan and Dauer, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F26E4.8 Aff_F26E4.8 tba-1; F26E4.8; F26E4.8.1; F26E4.8.2; 1K362; CE09692; NM_060199; TUBA3; WBGene00006528; WP:CE09692 TBA-2 tubulin alpha-2 chain Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, IVb male soma enriched genes F26F12.7 Aff_F26F12.7 chd-4; evl-11; let-418; F26F12.7; 5G311; CE17716; NM_072122; WBGene00002637; WP:CE17716 The let-418 gene encodes a homolog of Mi-2/CHD3, a component of the nucleosome remodeling and histone deacetylase (NURD) complex; LET-418 is similar to DNA helicases, homologous to human AIRE (OMIM:607358, mutated in autoimmune polyendocrinopathy syndrome), and paralogous to CHD-3; with MEP-1, LET-418 is required to repress germline-specific genes in somatic cells, and also negatively regulates RAS-dependent postembryonic vulval development (via the synMuvB pathway); LET-418 and CHD-3 are redundantly required for specification of secondary cell fates in vulval development; LET-418 is expressed in all interphase nuclei throughout development; LET-418 is bound by MEP-1, and also interacts with HDA-1 and PIE-1; these interactions probably reflect repression of LET-418 by PIE-1 in the germline. DNA helicase Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F26F4.10 Aff_F26F4.10 rrt-1; F26F4.10; F26F4.10a.1; F26F4.10a.2; F26F4.10b.1; F26F4.10b.2; 3G4; CE29495; CE37225; WBGene00004679; WP:CE29495; WP:CE37225 rrt-1 encodes an arginyl-tRNA synthetase that affects embryonic viability and fertility McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F26F4.11 Aff_F26F4.11 F26F4.11; 3G6; CE04448; WBGene00017830; WP:CE04448 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F26F4.12 Aff_F26F4.9 F26F4.12; 3F998; CE28922; WBGene00017831; WP:CE28922 Reinke et al 2004, wt herm vs wt male enriched gen F26F4.3 Aff_F26F4.3 rom-1; F26F4.3; 3F995; CE32392; NM_065628; WBGene00004400; WP:CE32392 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F26F4.4 Aff_F26F4.4 tag-340; F26F4.4; F26F4.4.1; F26F4.4.2; F26F4.4.3; 3F991; CE30767; WBGene00017826; WP:CE30767 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F26G5.9 Aff_F26G5.9 tam-1; F26G5.9; 5F438; CE09704; NM_071934; WBGene00006523; WP:CE09704 tam-1 encodes a broadly expressed nuclear protein with RING finger, B-box, and glutamine/asparagine-rich domains that promotes signalling in the class B synthetic-multivulva gene pathway (which includes the lin-35/RB gene), and also promotes the activity of genes in multicopy transgenic arrays; the normal role of TAM-1's class B activity is presumably to inhibit RAS pathway activity in vulval development, while TAM-1's effect on transgenes may be through changes in the acetylation state of histones in chromatin. Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma F26H11.1 Aff_F26H11.1 kbp-3; F26H11.1; 2O674; 2O676; CE26712; NM_064592; WBGene00009179; WP:CE26712 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F26H11.2 Aff_F26H11.2 nurf-1; F26H11.2; F26H11.2a.1; F26H11.2a.2; 2O693; CE15909; CE15910; CE35294; CE35295; CE35296; CE36931; CE37638; WBGene00009180; WP:CE15909; WP:CE15910; WP:CE35294; WP:CE35295; WP:CE35296; WP:CE36931; WP:CE37638 Bromodomain Kwon et al 2004 T1 transient-induction Ethanol-res, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, IVb male soma enriched genes F26H9.5 Aff_F26H9.5 F26H9.5; 1J890; CE09710; WBGene00009177; WP:CE09710 phosphoserine aminotransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ReichertK et al 2005 T3 xenobiotic downregulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F26H9.6 Aff_F26H9.6 CE-RAB5; rab-5; F26H9.6; F26H9.6.1; F26H9.6.2; 1J885; CE09711; NM_060080; WBGene00004268; WP:CE09711 rab-5 encodes a rab related protein of the Ras GTPase superfamily that affects both the localization of P-granules and of PAR-2, and also affects embryonic and larval viability and the cytoplasmic appearance of cells in the early embryo. RAS-related protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories F27C1.4 Aff_F27C1.4 F27C1.4; 1F991; CE09717; WBGene00017854; WP:CE09717 ViswanathanM et al 2005 S2 sir-2.1 regulated F27D4.2 Aff_F27D4.2 F27D4.2; F27D4.2.1; F27D4.2.2; F27D4.2.3; F27D4.2.4; 1I282; CE36140; WBGene00009188; WP:CE36140 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F27D4.4 Aff_F27D4.4 F27D4.4; 1I303; CE36141; WBGene00009189; WP:CE36141 Yeast hypothetical protein YOR316OW like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated F27D4.5 Aff_F27D4.5 tag-173; F27D4.5; F27D4.5.1; F27D4.5.2; 1I305; CE05736; WBGene00006518; WP:CE05736 tag-173/F27D4.5 is orthologous to the human gene BRANCHED CHAIN KETO ACID DEHYDROGENASE E1, ALPHA POLYPEPTIDE (BCKDHB; OMIM:248600), which when mutated leads to maple syrup urine disease, type 1a; F27D4.5 protein is predicted to be mitochondrial. 2-oxoisovalerate dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F27D9.5 Aff_F27D9.5 F27D9.5; CE04451; WBGene00017864; WP:CE04451; XI276 The F27D9.5 gene encodes an ortholog of the human gene PROPIONYL-COA CARBOXYLASE ALPHA SUBUNIT (PCCA), which when mutated leads to propionicaciduria, type I (OMIM:232000). Propionyl-coA carboxylase alpha chain precursor Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F27E5.2 Aff_F27E5.2 pax-3; F27E5.2; 2K439; CE35862; NM_063788; WBGene00003939; WP:CE35862 pax-3 encodes a divergent paired-like homeodomain protein that does not belong to the Q50, K50, or S50 classes; PAX-3 is required for locomotion and vulval development; pax-3(RNAi) animals have consistent Pvl and Unc phenotypes (as well as less consistent Bmd, Rup, and Stp phenotypes). 'Paired box' domain, homeobox protein (paired subfamily) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F27E5.4 Aff_F27E5.4 phas-1; phg-1; F27E5.4; 2K425; CE30964; NM_063785; WBGene00004017; WP:CE30964 growth arrest protein extracellular domain Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 F28B3.1 Aff_F28B3.1 F28B3.1; 1F517; CE36644; WBGene00017882; WP:CE36644 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F28B3.7 Aff_F28B3.7 him-1; smc-1; F28B3.7; F28B3.7a.1; F28B3.7a.2; 1F522; CE29497; CE39925; NM_059085; WBGene00001860; WP:CE29497; WP:CE39925 him-1 encodes a homolog of the conserved eukaryotic protein, SMC1, a member of the SMC (structural maintenance of chromosomes) superfamily that is required for embryonic viability, germline mitosis, chromosome pairing, and the segregation of mitotic chromosomes; HIM-1 can interact with SMC-3 and is required for DPY-28 localization to meiotic chromosomes; associates with the chromatin of transition-zone nuclei. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F28C6.1 Aff_F28C6.1 F28C6.1; 2I881; CE03272; WBGene00009202; WP:CE03272 transcription factor AP-2 like Portman et al 2004 T1 newly found ray-genes in25c, Portman et al 2004 T1 25 candidate ray genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F28C6.10 Aff_F28C6.10 F28C6.10; 2I899; CE09747; WBGene00009209; WP:CE09747 Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes F28C6.3 Aff_F28C6.3 cpf-1; F28C6.3; 2I892; CE03274; NM_063421; WBGene00000773; WP:CE03274 cleavage stimulation factor like Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F28C6.6 Aff_F28C6.6 suf-1; F28C6.6; 2I895; CE03277; NM_063424; WBGene00006307; WP:CE03277 polyadenylation factor like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F28C6.7 Aff_F28C6.7 rpl-26; F28C6.7; F28C6.7a.1; F28C6.7a.2; 2I893; CE03278; CE20731; CE32883; NM_063422; NM_063423; NM_182165; WBGene00004440; WP:CE03278; WP:CE20731; WP:CE32883 rpl-26 encodes a large ribosomal subunit L26 protein; by homology, RPL-26 is predicted to function in protein biosynthesis; in C. elegans, RPL-26 activity is required for embryonic and germline development and normal rates of postembryonic growth. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F28C6.8 Aff_F28C6.8 F28C6.8; 2I897; CE09746; WBGene00009207; WP:CE09746 MAP kinase phosphatase like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F28D1.10 Aff_F28D1.10 gex-3; F28D1.10; 4N171; CE05750; NM_069967; WBGene00001580; WP:CE05750 The gex-3 gene encodes a homolog of NAP1/NCKAP1, a mammalian protein ligand of the small GTPase Rac1, and of Drosophila HEM2/NAP1/KETTE; gex-3 is required for tissue morphogenesis and cell migrations; in gex-3 mutants, cells differentiate properly but fail to become organized. Drosophila dhem transmembrane protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F28D1.2 Aff_F28D1.2 F28D1.2; 4N140; CE05742; WBGene00009212; WP:CE05742 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F28D1.7 Aff_F28D1.7 rps-23; F28D1.7; F28D1.7.1; F28D1.7.2; 4N154; CE05747; NM_069964; WBGene00004492; WP:CE05747 rps-23 encodes a small ribosomal subunit S23 protein; by homology, RPS-23 is predicted to function in protein biosynthesis; in C. elegans, RPS-23 activity is required for germline development, vulval morphogenesis, and the overall health of the animal. ribosomal protein S23 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F28F8.3 Aff_F28F8.3 lsm-5; F28F8.3; F28F8.3.1; F28F8.3.2; 5Q49; CE09757; NM_074469; WBGene00003079; WP:CE09757 small nuclear ribonucleoprotein E (SNRNP-E) like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F28F8.5 Aff_F28F8.5 F28F8.5; 5Q54; CE09759; WBGene00009223; WP:CE09759 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F28H1.3 Aff_F28H1.3 ars-2; F28H1.3; F28H1.3.1; F28H1.3.2; F28H1.3.3; 1E553; CE09768; NM_058880; WBGene00000197; WP:CE09768 ars-2 encodes a predicted cytoplasmic alanyl-tRNA synthetase (AlaRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of alanine to its cognate tRNA and is thus required for protein biosynthesis; ARS-2 is essential for embryogenesis, and is required for fertility and a normal rate of postembryonic development; ARS-2 expression is likely ubiquitous and detected in hypodermis, intestine, neurons, and the pharynx from late embryogenesis through the adult stage of development. aminoacyl-tRNA synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F28H6.4 Aff_F28H6.4 F28H6.4; CE23688; WBGene00009233; WP:CE23688; XO751 ViswanathanM et al 2005 S2 sir-2.1 regulated F29A7.6 Aff_F29A7.6 F29A7.6; 2D42; CE09777; WBGene00017916; WP:CE09777 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F29B9.10 Aff_F29B9.10 F29B9.10; 4F422; CE09788; WBGene00017924; WP:CE09788 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated F29B9.2 Aff_F29B9.2 F29B9.2; 4F429; CE09781; CE27145; WBGene00017920; WP:CE09781; WP:CE27145 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F29B9.6 Aff_F29B9.6 ubc-9; F29B9.6; F29B9.6.1; F29B9.6.2; 4F417; CE09784; WBGene00006706; WP:CE09784 ubc-9 encodes an E2 ubiquitin-conjugating enzyme orthologous to Saccharomyces cerevisiae Ubc9p, which mediates the covalent attachment of the small ubiquitin-related modifier (SUMO) to various substrates including Ran-GAP1 and p53; UBC-9 activity is required for several developmental processes including embryogenesis, larval development, vulval development, posterior morphogenesis, and the DNA damage response (both DNA repair and DNA damage checkpoint function); UBC-9 interacts with LIN-1, an ETS-domain-containing transcription factor that negatively regulates vulval development, and with RAD-51, the C. elegans RecA homolog that is required for DNA repair; the expression pattern and subcellular localization of UBC-9 are not yet known. ubiquitin-conjugating enzyme McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated F29C12.3 Aff_F29C12.2 F29C12.3; CE39247; WBGene00009245; WP:CE39247 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F29C12.4 Aff_F29C12.4 F29C12.4; 2N411; CE19822; WBGene00009246; WP:CE19822 Elongation factor Tu family (contains ATP/GTP binding P-loop), Elongation factor G C-terminus McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated F29C4.7 Aff_F29C4.7 F29C4.7; F29C4.7a.1; F29C4.7a.2; F29C4.7b.1; F29C4.7b.2; 4A876; CE17724; CE31493; CE37226; WBGene00017929; WP:CE17724; WP:CE31493; WP:CE37226 F29C4.7 is orthologous to human RBM15 (OMIM:606077, mutated in infantile acute megakaryoblastic leukemia) and Drosophila NITO; F29C4.7 encodes a paralog of DIN-1; like DIN-1, it has N-terminal RNA recognition motifs (RRMs) and a C-terminal SID/RD (SMRT interaction domain/repressor) domain. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F29D10.4 Aff_F29D10.4 hum-1; F29D10.4; 1J422; CE05763; NM_059992; WBGene00002035; WP:CE05763 myosin McCarroll et al 2004 SFig5 conserved w/ yeast, McElwee et al 2003 T1 targets of daf-16, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F29D11.2 Aff_F29D11.2 F29D11.2; 1I212; CE09790; WBGene00009254; WP:CE09790 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F29F11.1 Aff_F29F11.1 sqv-4; F29F11.1; F29F11.1.1; F29F11.1.2; 5L140; CE05767; NM_073329; WBGene00005022; WP:CE05767 sqv-4 encodes a UDP-glucose 6-dehydrogenase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-4 is orthologous to Drosophila SUGARLESS, human UGDH (OMIM:603370), and zebrafish JEKYLL; SQV-4 is expressed in many cell types, notably oocytes and uterine, seam, pharyngeal, and spermathecal cells, with expression being prominent in 14 of the 22 vulval nuclei of late L4 larvae; the common requirement for SQV-4 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. UDP-glucose dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F29G9.3 Aff_F29G9.3 aps-1; apt-2; F29G9.3; 5G505; CE09797; NM_072158; WBGene00000159; WP:CE09797 The apt-2 gene encodes an adaptin: specifically, it encodes an ortholog of the sigma1 subunit of adaptor protein complex 1 (AP-1). clathrin coat assembly protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F30A10.1 Aff_F30A10.1 F30A10.1; 1K48; CE09802; WBGene00009260; WP:CE09802 calcineurin B subunit like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F30A10.6 Aff_F30A10.6 F30A10.6; 1K67; CE09807; WBGene00009264; WP:CE09807 Yeast recessive suppressor RSD1 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F30A10.9 Aff_F30A10.9 F30A10.9; 1K80; CE09810; WBGene00009266; WP:CE09810 Yeast D96591.6 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F31C3.1 Aff_F31C3.1 cyn-5; cyp-5; F31C3.1; F31C3.1.1; F31C3.1.2; 1P632; CE17730; NM_061223; WBGene00000881; WP:CE17730 cyp-5 encodes a cyclophilin that is functional in vitro and is predicted to be a secreted protein that is structurally most similar to human cyclophilin B; expressed in the intestine. cyclophillin McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F31C3.2 Aff_F31C3.2 F31C3.2; 1P631; CE17731; CE36143; WBGene00009284; WP:CE17731; WP:CE36143 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F31C3.4 Aff_F31C3.4 F31C3.4; 1P644; CE17733; WBGene00009286; WP:CE17733 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F31C3.5 Aff_F31C3.5 F31C3.5; 1P647; CE17734; WBGene00009287; WP:CE17734 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F31D4.1 Aff_F31D4.1 F31D4.1; 5V311; CE31921; WBGene00009289; WP:CE31921 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F31D4.3 Aff_F31D4.3 fkb-6; F31D4.3; F31D4.3.1; F31D4.3.2; 5V317; CE15929; NM_075625; WBGene00001431; WP:CE15929 FKBP-type peptidyl-prolyl cis-trans isomerases McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F31E3.1 Aff_F31E3.1 ceh-20; F31E3.1; 3I71; CE01241; WBGene00000443; WP:CE01241 A co-factor homeodomain protein and homolog of Drosophila Extradenticle (Exd) that together with ceh-40 affects embryogenesis, loss of both functions affect embryonic viability; it is required as a cofactor for LIN-39- and MAB-5- dependent postembryonic mesoderm patterning; it genetically interacts with unc-62. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F31E3.4 Aff_F31E3.4 F31E3.4; 3I54; CE01269; WBGene00017951; WP:CE01269 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F31E8.4 Aff_F31E8.4 F31E8.4; 2H90; CE07167; WBGene00017954; WP:CE07167 Lund et al 2002 Fig3D Oocyte-en, ViswanathanM et al 2005 S2 sir-2.1 regulated F32A11.1 Aff_F32A11.1 F32A11.1; 2N449; CE17737; WBGene00009307; WP:CE17737 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F32A6.3 Aff_F32A6.3 vps-41; F32A6.3; CE37009; CE38956; WBGene00017974; WP:CE37009; WP:CE38956; XF907 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma F32A6.4 Aff_F32A6.4 ags-3.1; ags-3; F32A6.4; CE04472; CE29783; CE34009; NM_171684; NM_171951; WBGene00000092; WP:CE04472; WP:CE29783; WP:CE34009; XF910 ags-3 encodes an ortholog of mammalian AGS3, a receptor independent activator of G protein signalling, and of Drosophila RAPSYNOID; AGS-3 proteins have four GoLoco motifs; AGS-3 is involved in polarity and spindle orientation during early embryogenesis; a region of AGS-3 encompassing three GoLoco motifs specifically binds GOA-1 in yeast two-hybrid assays; AGS-3 is expressed in all muscles, intestine, and weakly in some head and ventral nerve cord neurons, with subcellular localization in strong dots. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F32B5.8 Aff_F32B5.8 cpz-1; F32B5.8; 1D256; CE36646; NM_058622; WBGene00000788; WP:CE36646 cysteine proteinase Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, fem3 enriched genes, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F32B6.1 Aff_F32B6.1 nhr-4; F32B6.1; F32B6.1.1; F32B6.1.2; 4K645; CE24934; NM_069374; WBGene00003603; WP:CE24934 nhr-4 is predicted to encode a nuclear hormone receptor (NHR); expression may peak during the late larval stages, based on mRNA expression analysis. Ligand-binding domain of nuclear hormone receptors, Zinc finger, C4 type (two domains) ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F32B6.3 Aff_F32B6.3 F32B6.3; 4K646; CE35518; WBGene00009320; WP:CE35518 Human HPRP18 protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F32B6.9 Aff_F32B6.9 F32B6.9; 4K667; CE09864; WBGene00009323; WP:CE09864 Putative membrane protein F32D1.1 Aff_F32D1.1 figl-1; F32D1.1; 5E820; CE09865; WBGene00017981; WP:CE09865 F32D1.1 encodes an homolog of human SPASTIN (OMIM:604277, mutated in spastic paraplegia), FIDGETIN (OMIM:605295, mutated in fidget mice), and FIDGETIN-LIKE-1, and of Drosophila SPASTIN; recombinant F32D1.1 protein has N-ethylmaleimide-sensitive ATPase activity in vitro, which is strongly dependent on the C368 residue immediately C-terminal to its Walker A motif; F32D1.1 is required for persistence of the germline in RNAi assays. ATPase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F32D1.10 Aff_F32D1.10 mcm-7; F32D1.10; F32D1.10.1; F32D1.10.2; 5E827; CE09874; NM_071798; WBGene00003159; WP:CE09874 cell division control protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F32D1.5 Aff_F32D1.5 F32D1.5; F32D1.5.1; F32D1.5.2; 5E848; CE09869; WBGene00017984; WP:CE09869 GMP reductase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F32D8.6 Aff_F32D8.6 emo-1; oar-1; F32D8.6; F32D8.6.1; F32D8.6.2; 5L376; CE05785; NM_073377; WBGene00001303; WP:CE05785 emo-1 encodes an ortholog of S. cerevisiae Sec61p gamma subunit, which is required for translocation of secreted and membrane proteins into the endoplasmic reticulum; EMO-1 is required for oogenesis and ovulation. protein transport protein SEC61 gamma subunit McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F32E10.2 Aff_F32E10.2 F32E10.2; 4I341; CE04475; WBGene00017990; WP:CE04475 chromo domain of heterochromatin protein Jiang et al 2001 Fig1 hermaphrodite-enriched TF, Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories F32E10.5 Aff_F32E10.5 F32E10.5; 4I340; CE04478; WBGene00017992; WP:CE04478 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F32E10.6 Aff_F32E10.6 F32E10.6; F32E10.6.1; F32E10.6.2; 4I344; CE04479; WBGene00017993; WP:CE04479 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F32H2.2 Aff_F32H2.2 mdt-31; F32H2.2; 1J543; CE09877; NM_060012; WBGene00007026; WP:CE09877 Yeast SOH1 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F32H2.4 Aff_F32H2.4 F32H2.4; 1J547; CE28927; WBGene00009341; WP:CE28927 WD domain, G-beta repeat (3 domains) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F33A8.1 Aff_F33A8.1 let-858; F33A8.1; F33A8.1.1; F33A8.1.2; 2L317; CE17753; NM_063962; WBGene00002957; WP:CE17753 let-858 encodes nucampholin, a highly conserved protein rich in acidic and basic residues that also shares some similarity to eukaryotic initiation factor eIF-4 gamma; LET-858 is required for early embryogenesis and tissue differentiation and is expressed ubiquitously throughout development; LET-858 localizes to nuclei where it overlaps, but is not restricted to, chromosomal regions; based upon its sequence and localization, LET-858 is likely to be involved in protein synthesis and/or RNA binding. Link et al 2003 T2 Abeta induced, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Roy et al 2002 S3 muscle genes F33A8.3 Aff_F33A8.3 cey-1; F33A8.3; F33A8.3.1; F33A8.3.2; 2L330; CE17755; NM_063965; WBGene00000472; WP:CE17755 cey-1 encodes a protein with a cold-shock/Y-box domain that is expressed in early embryonic blastomeres (at the 15-cell stage, i.e., pre-gastrulation), but is normally repressed in early germline blastomeres by PIE-1; it is predicted to be mitochondrial by phylogenetic profiling. 'Cold-shock' DNA-binding domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F33A8.4 Aff_F33A8.4 F33A8.4; F33A8.4.1; F33A8.4.2; CE17756; NM_063967; WBGene00009352; WP:CE17756 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F33A8.6 Aff_F33A8.6 F33A8.6; 2L343; CE18659; WBGene00009354; WP:CE18659 Protein phosphatase 2C F33C8.1 Aff_F33C8.1 tag-53; F33C8.1; CE32400; CE32401; WBGene00006432; WP:CE32400; WP:CE32401; XP337 tag-53 encodes a protein with high similarity to human Attractin, and affects fertility and locomotion. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F33D11.10 Aff_F33D11.10 F33D11.10; F33D11.10.1; F33D11.10.2; 1G444; CE09901; WBGene00018007; WP:CE09901 intiation factor/helicase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F33D11.11 Aff_F33D11.11 F33D11.11; 1G446; CE09902; WBGene00018008; WP:CE09902 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F33E2.5 Aff_F33E2.5 F33E2.5; F33E2.5.1; F33E2.5.2; 1N184; CE09906; NM_060790; WBGene00009361; WP:CE09906 Jones et al 2001 Non dauer genes P<0.05 F33G12.4 Aff_F33G12.4 F33G12.4; F33G12.4.1; F33G12.4.2; F33G12.4.3; 2F326; CE27150; WBGene00018016; WP:CE27150 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F33H1.1 Aff_F33H1.1 daf-19; daf-24; F33H1.1; 2K448; CE17763; CE28019; WBGene00000914; WP:CE17763; WP:CE28019 DNA binding transcription factor Jones et al 2001 T2 lifespan and Dauer, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F33H1.3 Aff_F33H1.3 F33H1.3; 2K463; CE01569; WBGene00009364; WP:CE01569 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F33H2.1 Aff_F33H2.1 dog-1; F33H2.1; 1P610; CE17764; NM_061217; WBGene00001049; WP:CE17764 dog-1 encodes a predicted DEAH helicase, orthologous to the human BRCA1-binding protein BACH1 (OMIM:605882, mutated in early-onset breast cancer); DOG-1 is required for maintenance of polyguanine tracts of germline and somatic DNA, and is proposed to resolve the secondary structure that can occur in guanine-rich DNA during lagging-strand DNA synthesis. Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F33H2.2 Aff_F33H2.2 F33H2.2; 1P619; CE17765; WBGene00009366; WP:CE17765 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F33H2.3 Aff_F33H2.3 F33H2.3; F33H2.3.1; F33H2.3.2; 1P627; CE17766; WBGene00009367; WP:CE17766 Leucine Rich Repeat (2 copies) (2 domains) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F33H2.5 Aff_F33H2.5 F33H2.5; 1P598; CE17767; WBGene00009368; WP:CE17767 DNA polymerase family B (3 domains) Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories F33H2.7 Aff_F33H2.7 F33H2.7; 1P620; CE34302; WBGene00009370; WP:CE34302 Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F34H10.3 Aff_F34H10.3 F34H10.3; F34H10.3.1; F34H10.3.2; CE01573; WBGene00009380; WP:CE01573; XK252 protein S10 ViswanathanM et al 2005 S2 sir-2.1 regulated F35C8.4 Aff_F35C8.4 syn-1; F35C8.4; CE30968; NM_076508; WBGene00006371; WP:CE30968; XF971 syn-1 encodes a syntaxin (t-SNARE) homologous to mammalian and Drosophila syntaxin 1; by homology, SYN-1 is a predicted plasma membrane protein that mediates fusion events between exocytic vesicles and the plasma membrane; however, as loss of syn-1 activity via RNAi does not result in any obvious abnormalities, the precise role of syn-1 in C. elegans development and/or behavior is not yet known. ViswanathanM et al 2005 S2 sir-2.1 regulated F35D11.4 Aff_F35D11.4 F35D11.4; 2E893; CE32648; WBGene00018045; WP:CE32648 Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S4 Climbing, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S4 genes pass two-wayANOVA P0 F35D11.5 Aff_F35D11.5 F35D11.5; F35D11.5.1; F35D11.5.2; 2E892; CE29789; WBGene00018046; WP:CE29789 ViswanathanM et al 2005 S2 sir-2.1 regulated F35D2.3 Aff_F35D2.3 F35D2.3; 2H861; CE31804; WBGene00018041; WP:CE31804 Baugh et al 2005, PAL-1 target genes, Jones et al 2001 Non dauer genes P<0.05 F35D6.1 Aff_F35D6.1 fem-1; isx-1; F35D6.1; 4G298; CE07175; CE28299; NM_068423; NM_068424; WBGene00001411; WP:CE07175; WP:CE28299 The fem-1 gene encodes an ankyrin repeat-containing protein orthologous to human FEM1A and is required for masculinization of germline and somatic tissues; FEM-1 is widely expressed and functions as a second messenger in the sex determination pathway, connecting the membrane protein TRA-2A to the transcription factor TRA-1A which it negatively regulates; FEM-1 may also play a role in apoptosis, as it is a substrate for the CED-3 protease and can induce apoptosis when overexpressed in mammalian cells. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F35E12.3 Aff_F35E12.3 F35E12.3; 5O205; CE09918; WBGene00009427; WP:CE09918 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Ser/Thr protein phosphatases Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes F35G12.12 Aff_F35G12.12 F35G12.12; F35G12.12.1; F35G12.12.2; 3F673; CE31499; WBGene00009445; WP:CE31499 Lund et al 2002 Fig3C Germline-intrinsic, Lund et al 2002 Fig1 aging-regulated genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F35G12.2 Aff_F35G12.2 F35G12.2; F35G12.2.1; F35G12.2.2; F35G12.2.3; F35G12.2.4; 3F659; CE31500; WBGene00009440; WP:CE31500 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. isocitrate dehydrogenase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, Romagnolo et al 2002 Fig3b Oxidation, ViswanathanM et al 2005 S2 sir-2.1 regulated F35G12.4 Aff_F35G12.4 F35G12.4; F35G12.4a.1; F35G12.4a.2; 3F671; CE31501; CE31502; WBGene00009441; WP:CE31501; WP:CE31502 WD domain, G-beta repeat Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F35G12.6 Aff_F35G12.6 mab-21; F35G12.6; 3F691; CE32651; NM_065539; WBGene00003112; WP:CE32651 mab-21 encodes a novel protein that is a member of a highly conserved family of proteins with Drosophila and vertebrate orthologs; MAB-21 is cell-autonomously required for specifying the identity of sensory ray 6 in the male tail, and also for backward locomotion, normal body morphology, fecundity, and embryonic morphogenesis; MAB-21 expression begins in embryonic hypodermal cells and continues in larval and adult animals in hypodermis, anterior and ventral cord neurons, some body wall muscles, and ray cells. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F35G12.7 Aff_F35G12.7 F35G12.7; 3F676; CE32184; WBGene00009443; WP:CE32184 ViswanathanM et al 2005 S2 sir-2.1 regulated F35G12.8 Aff_F35G12.8 smc-4; F35G12.8; 3F681; CE03287; NM_065534; WBGene00004874; WP:CE03287 The smc-4 gene encodes a homolog of the SMC4 subunit of mitotic condensin; SMC-4 acts with MIX-1 to enable chromosome segregation. chromosome segregation protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories F35G12.9 Aff_F35G12.9 apc-11; F35G12.9; 3F684; CE00978; NM_065536; WBGene00000145; WP:CE00978 apc-11 encodes a predicted key catalytic subunit of the anaphase promoting complex that is required for embryonic development past the embryonic one- cell stage. Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F35H10.11 Aff_F17E9.9 his-29; F35H10.11; 4J92; NM_069002; WBGene00001903 his-29 encodes an H2B histone. histone H2B F35H10.6 Aff_F35H10.6 F35H10.6; 4J65; CE38515; WBGene00018071; WP:CE38515 ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT F35H10.7 Aff_F35H10.7 F35H10.7; 4J63; CE04507; WBGene00018072; WP:CE04507 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F36A2.1 Aff_F36A2.1 F36A2.1; F36A2.1a.1; F36A2.1a.2; 1J382; CE39364; CE39365; WBGene00009451; WP:CE39364; WP:CE39365 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F36A2.13 Aff_F36A2.13 F36A2.13; 1J404; CE24948; WBGene00009460; WP:CE24948 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories F36A2.2 Aff_F36A2.2 F36A2.2; 1J378; CE09942; WBGene00009452; WP:CE09942 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Yeast protein 8248 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F36A2.6 Aff_F36A2.6 rps-15; F36A2.6; F36A2.6.1; F36A2.6.2; 1J392; CE09945; NM_059983; WBGene00004484; WP:CE09945 rps-15 encodes a small ribosomal subunit S15 protein. 40S ribosomal protein S15 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F36A2.7 Aff_F36A2.7 F36A2.7; F36A2.7.1; F36A2.7.2; 1J391; CE09946; WBGene00009454; WP:CE09946 ViswanathanM et al 2005 S2 sir-2.1 regulated F36A2.8 Aff_F36A2.8 F36A2.8; 1J389; CE32406; WBGene00009455; WP:CE32406 Drosophila sex-regulated protein janus like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F36A2.9 Aff_F36A2.9 F36A2.9; 1J397; CE32407; CE32408; WBGene00009456; WP:CE32407; WP:CE32408 phospholipase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F36A4.7 Aff_F36A4.7 ama-1; F36A4.7; 4F21; CE28300; NM_068122; WBGene00000123; WP:CE28300 ama-1 encodes the large subunit of RNA polymerase II required for mRNA transcription; AMA-1 is essential for proper embryonic development, particularly for the early division and migration of the endodermal precursor (E) cells that initiate gastrulation; AMA-1 is expressed ubiquitously in the developing embryo until the 550-cell stage. RNA polymerase II McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes F36D1.1 Aff_F36D1.1 F36D1.1; 1L870; CE19832; WBGene00009461; WP:CE19832 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F36D3.1 Aff_F36D3.1 F36D3.1; F36D3.1.1; F36D3.1.2; 5Q981; CE25872; WBGene00009469; WP:CE25872 ViswanathanM et al 2005 S2 sir-2.1 regulated F36D4.2 Aff_F36D4.2 F36D4.2; 5J881; CE07190; WBGene00018088; WP:CE07190 synbindin TRS23 family McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F36D4.5 Aff_F36D4.5 F36D4.5; F36D4.5b.1; F36D4.5b.2; F36D4.5b.3; F36D4.5b.4; 5J900; CE28391; CE30778; WBGene00018090; WP:CE28391; WP:CE30778 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F36G3.2 Aff_F36G3.2 F36G3.2; CE01577; WBGene00009483; WP:CE01577; XK412 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F36H1.1 Aff_F36H1.1 fkb-1; F36H1.1; 4L801; CE05813; NM_069655; WBGene00001426; WP:CE05813 fkb-1 encodes a homolog of mouse FK506-binding protein 2. FK506-binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated F36H2.1 Aff_F36H2.1 tat-5; F36H2.1; 1J812; CE34183; CE34184; CE39367; WBGene00009498; WP:CE34183; WP:CE34184; WP:CE39367 E1-E2 ATPase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F37A4.1 Aff_F37A4.1 F37A4.1; F37A4.1.1; F37A4.1.2; F37A4.1.3; 3H813; CE00711; WBGene00018131; WP:CE00711 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F37A4.2 Aff_F37A4.2 F37A4.2; 3H811; CE00710; WBGene00018132; WP:CE00710 F37A4.8 Aff_F37A4.8 isw-1; F37A4.8; 3H794; CE29792; NM_066067; WBGene00002169; WP:CE29792 isw-1 encodes a homolog of the chromatin remodeling ATPase ISW1 that may act downstream of or in parallel to synMuv genes, and upstream of or in parallel to the RTK Ras pathway. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F37B12.2 Aff_F37B12.2 gcs-1; F37B12.2; F37B12.2.1; F37B12.2.2; 2J326; CE32886; NM_063526; WBGene00001527; WP:CE32886 gcs-1 encodes the C. elegans ortholog of gamma-glutamine cysteine synthetase heavy chain (GCS(h)); GCS-1 is predicted to function, in a conserved oxidative stress response pathway, as a phase II detoxification enzyme that catalyzes the rate-limiting first step in glutathione biosynthesis; a GCS-1::GFP reporter fusion is expressed in larvae and adults in the pharynx, ASI chemosensory neurons, and anterior and posterior intestine and upon exposure to oxidative stress, such as heat or herbicide, the intestinal expression increases dramatically; constitutive and stress-inducible GCS-1::GFP expression in the ASI neurons and intestine, respectively, is under the control of the SKN-1 CNC transcription factor; loss of gcs-1 activity via RNAi results in a low percentage of larval lethality and intestinal abnormalities suggesting that gcs-1 plays a role in postembryonic development. glutamate-cysteine ligase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol F37C12.1 Aff_F37C12.1 F37C12.1; 3I277; CE00742; WBGene00018149; WP:CE00742 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F37C12.11 Aff_F37C12.11 rps-21; F37C12.11; F37C12.11.1; F37C12.11.2; 3I278; CE30779; NM_066178; WBGene00004490; WP:CE30779 rps-21 encodes a small ribosomal subunit S21 protein; by homology, RPS-21 is predicted to function in protein biosynthesis; in C. elegans, RPS-21 activity is required for embryonic and germline development, as well as the overall health of the animal. Ribosomal protein S21 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F37C12.2 Aff_F37C12.2 F37C12.2; 3I275; CE00741; WBGene00018150; WP:CE00741 Link et al 2003 T2 Abeta induced, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F37C12.3 Aff_F37C12.3 F37C12.3; F37C12.3.1; F37C12.3.2; 3I273; CE33082; WBGene00018151; WP:CE33082 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ViswanathanM et al 2005 S2 sir-2.1 regulated F37C12.4 Aff_F37C12.4 rpl-36; F37C12.4; F37C12.4.1; F37C12.4.2; F37C12.4.3; 3I271; CE30781; NM_066172; WBGene00004450; WP:CE30781 rpl-36 encodes a large ribosomal subunit L36 protein; by homology, RPL-36 is predicted to function in protein biosynthesis; in C. elegans, RPL-36 activity is required for embryonic and germline development and normal postembryonic growth rates. Ribosomal protein YL39 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F37C12.7 Aff_F37C12.7 F37C12.7; 3I259; CE29312; WBGene00018152; WP:CE29312 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F37C12.9 Aff_F37C12.9 rps-14; F37C12.9; F37C12.9.1; F37C12.9.2; 3I268; CE00821; NM_066171; WBGene00004483; WP:CE00821 rps-14 encodes a small ribosomal subunit S14 protein; by homology, RPS-14 is predicted to function in protein biosynthesis; in C. elegans, RPS-14 activity is required for embryonic and germline development, as well as the overall health of the animal. Ribosomal protein S14 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F37C4.6 Aff_F37C4.6 F37C4.6; F37C4.6.1; F37C4.6.2; 4E640; CE17049; WBGene00018146; WP:CE17049 phytoene desaturase Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F37E3.1 Aff_F37E3.1 F37E3.1; 1H1; CE29793; WBGene00018156; WP:CE29793 CAP-binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F37F2.2 Aff_F37F2.2 F37F2.2; 1B916; CE32185; WBGene00018159; WP:CE32185 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F37H8.1 Aff_F37H8.1 lir-3; F37H8.1; 2L474; CE15994; NM_063994; WBGene00003046; WP:CE15994 lir-3 encodes a lin-26-related protein that shares a unique C2H2 motif together with lir-1, lir-2 and lin-26; contains a region rich in acidic residues suggesting that it may be a transcription factor. Zinc finger, C2H2 type ViswanathanM et al 2005 S2 sir-2.1 regulated F38A5.1 Aff_F38A5.1 F38A5.1; 4H346; CE10028; CE33641; WBGene00018160; WP:CE10028; WP:CE33641 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F38A5.10 Aff_F38A5.10 nspb-4; F38A5.10; 4H361; CE10044; WBGene00018167; WP:CE10044 nspb family Bishop et al 2004 T4 57 vhl-1 depend hif-1 indep, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F38A5.2 Aff_F38A5.2 F38A5.2; F38A5.2b.1; F38A5.2b.2; CE34010; CE34011; WBGene00018161; WP:CE34010; WP:CE34011 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F38A5.7 Aff_F38A5.7 F38A5.7; 4H367; CE10038; WBGene00018164; WP:CE10038 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F38B2.4 Aff_F38B2.4 F38B2.4; F38B2.4.1; F38B2.4.2; CE02218; WBGene00009531; WP:CE02218; XL906 F38B2.4 is orthologous to the human gene ADENYLATE KINASE 1 (AK1; OMIM:103000), which when mutated leads to hemolytic anemia. adenylate kinase Link et al 2003 T2 Abeta repressed, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b Metabolism, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F38E1.9 Aff_F38E1.9 F38E1.9; 5I838; CE04527; WBGene00018181; WP:CE04527 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated F38E11.3 Aff_F38E11.3 cpin-1; F38E11.3; 4K215; CE26624; NM_069268; WBGene00000775; WP:CE26624 cpi-1 is orthologous to a mammalian protein variously identified as guanine aminohydrolase (or guanine deaminase, or guanase), cypin, or p51-nedasin. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F38H4.10 Aff_F38H4.10 F38H4.10; 4M625; CE32887; WBGene00009551; WP:CE32887 Yeast hypothetical protein YIK6 like Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F38H4.8 Aff_F38H4.8 ech-2; F38H4.8; 4M616; CE17808; NM_069845; WBGene00001151; WP:CE17808 enoyl-CoA hydratase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 F38H4.9 Aff_F38H4.9 PP2A-C; let-92; F38H4.9; F38H4.9.1; F38H4.9.2; 4M623; CE10074; NM_069846; WBGene00002363; WP:CE10074 let-92 encodes a homolog of PP2AC, the catalytic subunit of protein phosphatase 2A (PP2A), identified genetically in screens for essential genes on chromosome IV; LET-92 may regulate a number of signal transduction pathways as it is required for embryogenesis, larval development, Ras-mediated vulval development, and axonal guidance in the DD and VD neurons; let-92 interacts genetically with sur-6 which encodes a regulatory subunit of PP2A; LET-92 protein is bound both by SMG-2 and by POS-1, and also interacts in vitro with UNC-51 and UNC-14; LET-92 is expressed cytoplasmically in nearly all cells and strongly in many neurons. serine/threonine protein phosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F39B1.1 Aff_F39B1.1 F39B1.1; CE05832; WBGene00009552; WP:CE05832; XP854 phosphatidylinositol 3-kinase like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol F39B2.1 Aff_F39B2.1 F39B2.1; 1P385; CE16007; WBGene00009553; WP:CE16007 Zinc finger, C2H2 type (7 domains) Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories F39B2.10 Aff_F39B2.10 dnj-12; F39B2.10; F39B2.10.1; F39B2.10.2; F39B2.10.3; F39B2.10.4; 1P351; CE16015; NM_061169; WBGene00001030; WP:CE16015 This gene encodes a protein containing a DnaJ ('J') domain. DnaJ, prokaryotic heat shock protein Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated F39B2.2 Aff_F39B2.2 mms-2; uev-1; F39B2.2; F39B2.2.1; F39B2.2.2; 1P383; CE16008; NM_061177; WBGene00006730; WP:CE16008 uev-1 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the characteristic UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; as loss of UEV-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UEV-1 in C. elegans development and/or behavior is not yet known; UEV-1 does, however, interact with a number of proteins, such as UBC-13, that are likely involved in the response to DNA damage; thus, UEV-1 may play a role in ubiquitination and protein turnover in conjunction with DNA repair or the DNA damage checkpoint pathway. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F39B2.4 Aff_F39B2.4 mdt-23; sur-2; F39B2.4; 1P370; CE28023; CE28024; NM_061174; WBGene00006349; WP:CE28023; WP:CE28024 SUR-2 PROTEIN Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F39B2.5 Aff_F39B2.5 F39B2.5; F39B2.5.1; F39B2.5.2; 1P354; CE34485; WBGene00009556; WP:CE34485 Src homology domain 2 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Romagnolo et al 2002 Fig3b signaling F39B2.6 Aff_F39B2.6 rps-26; F39B2.6; F39B2.6.1; F39B2.6.2; 1P353; CE16012; NM_061170; WBGene00004495; WP:CE16012 rps-26 encodes a small ribosomal subunit S26 protein; by homology, RPS-26 is predicted to function in protein biosynthesis; in C. elegans, RPS-26 activity is required for embryonic, larval, and germline development, as well as normal locomotion and body morphology. 40S ribosomal protein S26 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F39G3.1 Aff_F39G3.1 ugt-61; F39G3.1; 5F221; CE30782; WBGene00018206; WP:CE30782 7TM chemoreceptor, ugt family F39G3.3 Aff_F39G3.3 F39G3.3; 5F211; CE33083; WBGene00018208; WP:CE33083 ViswanathanM et al 2005 S2 sir-2.1 regulated F39G3.7 Aff_F39G3.7 pex-6; prx-6; F39G3.7; 5F194; CE10124; NM_071867; WBGene00004195; WP:CE10124 ATPase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F39H11.1 Aff_F39H11.1 F39H11.1; 1J273; CE27158; WBGene00009565; WP:CE27158 Yeast YB81 protein like ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F39H11.2 Aff_F39H11.2 tlf-1; F39H11.2; 1J274; CE27159; NM_059955; WBGene00006577; WP:CE27159 The tlf-1 gene encodes a TATA binding protein (TBP)-like factor (TLF-1); TLF-1 is a functional transcriptional factor, and is required in vivo for zygotic embryonic RNA polymerase II transcription. transcription factor TFIID like F39H11.3 Aff_F39H11.3 cdk-8; F39H11.3; 1J281; CE32409; NM_059956; WBGene00000409; WP:CE32409 cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development. serine/threonine kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F39H2.2 Aff_F39H2.2 cyn-14; cyp-14; sig-7; F39H2.2; F39H2.2b.1; F39H2.2b.2; 1J227; CE32410; CE32411; NM_059942; NM_182005; WBGene00000890; WP:CE32410; WP:CE32411 cyp-14 encodes a predicted cyclophilin. peptidylprolyl isomerase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F39H2.4 Aff_F39H2.4 syp-3; F39H2.4; 1J240; CE17814; NM_059944; WBGene00006377; WP:CE17814 Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F39H2.5 Aff_F39H2.1 F39H2.5; F39H2.5.1; F39H2.5.2; 1J239; CE30531; WBGene00009564; WP:CE30531 Jones et al 2001 T3 20 most abundant Dauer, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes F40E10.6 Aff_F40E10.6 F40E10.6; F40E10.6.1; F40E10.6.2; F40E10.6.3; CE31508; WBGene00009574; WP:CE31508; XP322 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F40F11.1 Aff_F40F11.1 rps-11; F40F11.1; F40F11.1.1; F40F11.1.2; 4M367; CE05860; NM_069785; WBGene00004480; WP:CE05860 rps-11 encodes a small ribosomal subunit S11 protein; by homology, RPS-11 is predicted to function in protein biosynthesis; in C. elegans, RPS-11 activity is required for embryonic and germline development, as well as the overall health of the animal. ribosomal protein S11 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F40F4.3 Aff_F40F4.3 lbp-1; F40F4.3; CE04533; NM_076156; WBGene00002253; WP:CE04533; XD879 fatty acid-binding protein McElwee et al 2003 T1 targets of daf-16, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F40F4.4 Aff_F40F4.4 lbp-3; F40F4.4; CE30130; CE39932; NM_076155; WBGene00002255; WP:CE30130; WP:CE39932; XD877 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, Roy et al 2002 S3 muscle genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F40F4.7 Aff_F40F4.7 F40F4.7; CE28316; WBGene00018238; WP:CE28316; XD864 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F40F8.10 Aff_F40F8.10 rps-9; F40F8.10; F40F8.10.1; F40F8.10.2; F40F8.10.3; 2L416; CE05849; NM_063983; WBGene00004478; WP:CE05849 rps-9 encodes a small ribosomal subunit S9 protein. ribosomal protein S9 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F40F8.5 Aff_F40F8.5 F40F8.5; 2L424; CE32888; WBGene00009578; WP:CE32888 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F40F8.9 Aff_F40F8.9 lsm-1; F40F8.9; F40F8.9.1; F40F8.9.2; 2L417; CE05848; NM_063984; WBGene00003076; WP:CE05848 Yeast J0714 like Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F40F9.6 Aff_F40F9.6 F40F9.6; F40F9.6b.1; F40F9.6b.2; 5K206; CE05855; CE23714; WBGene00009583; WP:CE05855; WP:CE23714 glycosyl hydrolase F40F9.7 Aff_F40F9.7 F40F9.7; F40F9.7a.1; F40F9.7a.2; F40F9.7b.1; F40F9.7b.2; F40F9.7b.3; F40F9.7b.4; 5K213; CE05856; CE33580; WBGene00009584; WP:CE05856; WP:CE33580 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F40G9.11 Aff_F40G9.11 mxl-2; F40G9.11; 3A804; CE19858; NM_064772; WBGene00003510; WP:CE19858 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F40G9.2 Aff_F40G9.2 F40G9.2; 3A809; CE19849; WBGene00018240; WP:CE19849 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F40G9.3 Aff_F40G9.3 ubc-20; F40G9.3; 3A807; CE19850; NM_064773; WBGene00006715; WP:CE19850 ubiquitin conjugating enzyme McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F41B4.3 Aff_F41B4.3 F41B4.3; CE07213; WBGene00018259; WP:CE07213; XH454 ViswanathanM et al 2005 S2 sir-2.1 regulated F41C3.3 Aff_F41C3.3 acs-11; F41C3.3; F41C3.3.1; F41C3.3.2; 2F35; CE32658; WBGene00018269; WP:CE32658 Long-chain-fatty-acid coA ligase ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F41C3.4 Aff_F41C3.4 F41C3.4; 2F31; CE39501; WBGene00018270; WP:CE39501 ViswanathanM et al 2005 S2 sir-2.1 regulated F41E6.13 Aff_F41E6.13 tag-283; F41E6.13; F41E6.13b.1; F41E6.13b.2; 5J110; CE10268; CE30784; WBGene00018294; WP:CE10268; WP:CE30784 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F41E6.9 Aff_F41E6.9 F41E6.9; 5J86; CE10260; WBGene00018290; WP:CE10260 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F41H10.3 Aff_F41H10.3 F41H10.3; 4G139; CE10276; CE31694; WBGene00018316; WP:CE10276; WP:CE31694 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F41H10.6 Aff_Y4C6B.A F41H10.6; 4G122; CE20772; CE25887; WBGene00018319; WP:CE20772; WP:CE25887 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F42A10.1 Aff_F42A10.1 F42A10.1; F42A10.1.1; F42A10.1.2; F42A10.1.3; 3H265; CE01292; WBGene00018339; WP:CE01292 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F42A6.6 Aff_F42A6.6 F42A6.6; 4E94; CE34559; WBGene00018328; WP:CE34559 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F42A6.7 Aff_F42A6.7 hrp-1; rbp-1; F42A6.7; F42A6.7a.1; F42A6.7a.2; F42A6.7a.3; F42A6.7b.1; F42A6.7b.2; F42A6.7b.3; F42A6.7b.4; 4E102; CE17059; CE29317; CE31510; CE39251; NM_067925; WBGene00001999; WP:CE17059; WP:CE29317; WP:CE31510; WP:CE39251 The hrp-1 gene encodes a homolog of the human DRPLA gene (OMIM:125370), which when mutated leads to dentatorubral-pallidoluysian atrophy or to Haw River syndrome (OMIM:140340). McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F42A8.3 Aff_F42A8.3 F42A8.3; 2J643; CE35875; WBGene00009627; WP:CE35875 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E F42A9.2 Aff_F42A9.2 lin-49; F42A9.2; 4J389; CE07224; NM_069074; WBGene00003034; WP:CE07224 zinc-finger protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F42C5.8 Aff_F42C5.8 rps-8; F42C5.8; F42C5.8.1; F42C5.8.2; 4I78; CE04561; NM_068766; WBGene00004477; WP:CE04561 rps-8 encodes a small ribosomal subunit S8 protein; by homology, RPS-8 is predicted to function in protein biosynthesis; in C. elegans, RPS-8 activity is required for germline development and the overall health of the animal. 40S ribosomal protein S8 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F42E11.2 Aff_F42E11.2 F42E11.2; CE03309; CE23715; CE31512; WBGene00009632; WP:CE03309; WP:CE23715; WP:CE31512; XL991 F42G8.11 Aff_F42G8.11 sph-1; F42G8.11; 4I896; CE17070; NM_068959; WBGene00004979; WP:CE17070 sph-1 encodes a member of the synaptophysin/synaptoporin family that contains a MARVEL domain, a membrane-associating domain found in lipid-associating proteins, and contains a transmembrane domain. synaptic vesicle channel protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F42G9.1 Aff_F42G9.1 F42G9.1; 3B403; CE07231; CE30788; WBGene00018362; WP:CE07231; WP:CE30788 Protein phosphatase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, herm sperm, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F42G9.2 Aff_F42G9.2 cyn-6; cyp-6; F42G9.2; 3B391; CE01301; NM_064856; WBGene00000882; WP:CE01301 cyp-6 encodes a cyclophilin most similar to human secreted cyclophilin type B isoforms that is functional when expressed in E. coli; it is expressed in the intestine. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F42H10.6 Aff_F42H10.6 F42H10.6; F42H10.6.1; F42H10.6.2; 3J568; CE24969; WBGene00018370; WP:CE24969 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F42H10.7 Aff_F42H10.7 F42H10.7; 3J578; CE00169; CE37109; WBGene00018371; WP:CE00169; WP:CE37109 Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F42H11.2 Aff_F42H11.2 lem-3; F42H11.2; F42H11.2.1; F42H11.2.2; 1K156; CE10332; NM_060138; WBGene00002276; WP:CE10332 ankyrin domain Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F43D9.2 Aff_F43D9.2 rab-33; F43D9.2; 3L590; CE00992; NM_066913; WBGene00004283; WP:CE00992 F43E2.2 Aff_F43E2.2 F43E2.2; 2H665; CE28327; WBGene00018391; WP:CE28327 ViswanathanM et al 2005 S2 sir-2.1 regulated F43E2.4 Aff_F43E2.4 haf-2; F43E2.4; 2H644; CE07240; NM_063136; WBGene00001812; WP:CE07240 haf-2 encodes a predicted transmembrane protein of the ATP-binding cassette (ABC) transporter superfamily; by homology, HAF-2 is proposed to function in ATP-dependent transport of molecules across plasma and intracellular membranes; however, as loss of HAF-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of HAF-2 in C. elegans development and/or behavior is not yet known. membrane transport protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F43E2.7 Aff_F43E2.7 F43E2.7; 2H664; CE32664; CE33087; WBGene00018395; WP:CE32664; WP:CE33087 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F43G6.1 Aff_F43G6.1 dna-2; F43G6.1; 2M71; CE02219; CE23725; NM_064114; NM_064115; WBGene00001016; WP:CE02219; WP:CE23725 dna-2 encodes the C. elegans ortholog of the yeast and vertebrate Dna2 replication helicases; by homology, DNA-2 is predicted to function as an endonuclease and an ATP-dependent helicase that is involved in DNA replication and repair; in C. elegans, DNA-2 activity is required maternally and zygotically to maintain normal rates of cell division and for proper germ-line, embryonic, and larval development; DNA-2 activity is temperature-sensitive: animals lacking DNA-2 at 16 degrees Celsius (C) are less severely affected than those at 20 or 25 degrees C; in the hermaphrodite gonad, DNA-2 localizes to nuclei of germ cells and developing oocytes, and expression continues in embryos up to the comma stage; DNA-2 then reappears at the L3 larval stage, and in L3 and L4 larvae is visible in the proliferating somatic cells of the uterus and spermatheca. ViswanathanM et al 2005 S2 sir-2.1 regulated F43G6.7 Aff_F43G6.7 F43G6.7; 2M101; CE02225; WBGene00009659; WP:CE02225 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F43G9.10 Aff_F43G9.10 F43G9.10; 1J216; CE10372; WBGene00009671; WP:CE10372 MICROFIBRILLAR-ASSOCIATED PROTEIN 1 (ASSOCIATED MICROFIBRIL PROTEIN) (AMF) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Cell Structure, ViswanathanM et al 2005 S2 sir-2.1 regulated F43G9.12 Aff_F43G9.12 F43G9.12; 1J219; CE17822; WBGene00009672; WP:CE17822 Human GC-rich sequence DNA-binding factor (GCF) like Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen F43G9.4 Aff_F43G9.4 F43G9.4; 1J184; CE10360; WBGene00009667; WP:CE10360 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F43G9.5 Aff_F43G9.5 F43G9.5; 1J193; CE10362; WBGene00009668; WP:CE10362 F43G9.5 encodes a NUDIX hydrolase that is a (perhaps evolutionarily conserved) target of transcriptional activation by DAF-16; loss of F43G9.5 function has no obvious effect on lifespan, dauer formation, or fat storage. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F43H9.1 Aff_F43H9.1 ech-3; F43H9.1; 5I503; CE07245; NM_072665; WBGene00001152; WP:CE07245 enoyl-coA hydratase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F44A6.1 Aff_F44A6.1 nucb-1; F44A6.1; CE03322; CE31514; NM_171763; NM_171970; WBGene00009674; WP:CE03322; WP:CE31514; XK817 F44A6.1 encodes two isoforms of a nucleobindin homolog that each contain a calcium-binding EF-hand domain and a glutamine/asparagine-rich domain; F44A6.1 is expressed in muscle (pharyngeal, body wall, and vulval), with weak expression in head and tail neurons and in (mainly posterior) intestinal cells; F44A6.1 has no obvious function in vivo, since it has no obvious phenotype when deleted or inactivated by RNAi (whether in a normal genetic background, or in goa-1 and egl-30 mutant backgrounds). nucleobindin Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated F44A6.2 Aff_F44A6.2 nhr-24; sex-1; F44A6.2; F44A6.2.1; F44A6.2.2; CE03323; NM_077312; WBGene00004786; WP:CE03323; XK820; cnr14 sex-1 encodes a DNA-binding protein that is a member of the nuclear hormone receptor superfamily of transcriptional regulators; during embryonic development, SEX-1 functions as an X chromosome signal element that transmits the primary sex-determination signal by negatively regulating transcription of xol-1, a gene whose expression levels correlate with hermaphrodite or male development (low xol-1 levels result in hermaphrodite development, high xol-1, in that of males); in vivo, SEX-1 can associate with extrachromosomal arrays containing the xol-1 promoter, indicating that SEX-1's affect on xol-1 transcription is likely to be direct; SEX-1 localizes to nuclei from oogenesis through mid-embryogenesis, with highest levels of expression visible during early gastrulation (28-100-cell-stage); the SEX-1 expression pattern appears to be similar in hermaphrodites and males. nuclear hormone receptor ViswanathanM et al 2005 S2 sir-2.1 regulated F44B9.5 Aff_F44B9.5 F44B9.5; F44B9.5.1; F44B9.5.2; 3J104; CE24973; WBGene00018408; WP:CE24973 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F44B9.7 Aff_F44B9.7 pqn-38; F44B9.7; 3J116; CE29043; NM_066348; WBGene00004125; WP:CE29043 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F44D12.5 Aff_F44D12.5 F44D12.5; 4K795; WBGene00009682 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F44E2.2 Aff_F44E2.2 F44E2.2; 3J949; CE00180; CE07254; CE29321; WBGene00018416; WP:CE00180; WP:CE07254; WP:CE29321 Reverse Transcriptase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F44E2.3 Aff_F44E2.3 F44E2.3; 3J918; CE00181; WBGene00018417; WP:CE00181 DnaJ Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F44E2.6 Aff_F44E2.6 F44E2.6; 3J934; CE00184; WBGene00018419; WP:CE00184 Transcription regulation McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F44E2.8 Aff_F44E2.8 F44E2.8; 3J938; CE32420; WBGene00018421; WP:CE32420 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F44E7.2 Aff_F44E7.2 F44E7.2; 5G251; CE17072; WBGene00018424; WP:CE17072 nitrophenylphosphatase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F44E7.9 Aff_F44E7.9 F44E7.9; 5G271; CE10396; WBGene00018431; WP:CE10396 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F45C12.5 Aff_F45C12.5 fbxb-11; F45C12.5; 2C15; CE10444; WBGene00018436; WP:CE10444 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F45C12.7 Aff_F45C12.7 F45C12.7; 2C5; CE10448; WBGene00018438; WP:CE10448 Jones et al 2001 Non dauer genes P<0.05, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F45D11.10 Aff_F45D11_39.B F45D11.10; 2B281; CE23733; WBGene00018456; WP:CE23733 F45E1.6 Aff_F45E1.6 his-71; F45E1.6; F45E1.6.1; F45E1.6.2; CE01943; NM_076943; WBGene00001945; WP:CE01943; XI600 his-71 encodes an H3 histone required for embryonic viability, body morphology, and larval viability. Histone H3 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F45E12.1 Aff_F45E12.1 F45E12.1; 2H603; CE02737; WBGene00018474; WP:CE02737 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F45E12.2 Aff_F45E12.2 brf-1; F45E12.2; 2H597; BRF; CE02738; NM_063125; WBGene00000271; WP:CE02738 brf-1 encodes an ortholog of mammalian B-RELATED FACTOR (also known as BRF, TDS4, PCF4, or hTFIIIB90); BRF is thought to act as a molecular bridge between TATA-binding protein (TBP) associated factors that functions in TFIIIB (RNA polymerase III associated transcription factors). transcription initiation factor IIB Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F45E12.5 Aff_F45E12.4 F45E12.5; F45E12.5b.1; F45E12.5b.2; 2H598; CE02741; CE32049; WBGene00018475; WP:CE02741; WP:CE32049 ViswanathanM et al 2005 S2 sir-2.1 regulated F45E4.10 Aff_F45E4.10 gfi-4; F45E4.10; F45E4.10b.1; F45E4.10b.2; 4I412; CE31701; CE31702; NM_068845; NM_068846; WBGene00001584; WP:CE31701; WP:CE31702 gfi-4 encodes a novel protein that was identified in screens for proteins that interact with GEI-4, a coiled-coil domain protein required for embryonic viability, fertility, and vulval morphogenesis that also interacts with GEX-2, a putative Rac-binding protein, and intermediate filaments; based on its interaction with GEI-4, GFI-4 may be predicted to play a role in intermediate filament rearrangements during germline development or embryonic or vulval morphogenesis; however, as loss of gfi-4 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GFI-4 in C. elegans development and/or behavior is not yet known. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F45E4.2 Aff_F45E4.2 plp-1; F45E4.2; F45E4.2.1; F45E4.2.2; 4I399; CE10494; NM_068840; WBGene00004046; WP:CE10494 plp-1 encodes a protein containing three PUR repeats that are predicted to bind DNA/RNA and has similarity to the mammalian transcription factor pur alpha, and is required for embryonic development, development of the pharynx, and affects formation of the intestine; interacts with an Lef-1 site within the end-1 promoter and binding is regulated by phosphorylation Baugh et al 2005, PAL-1 target genes, Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b TF, ViswanathanM et al 2005 S2 sir-2.1 regulated F45E4.9 Aff_F45E4.9 hmg-5; F45E4.9; 4I410; CE10508; NM_068844; WBGene00001975; WP:CE10508 Baugh et al 2005, PAL-1 target genes, Jiang et al 2001 Fig1 hermaphrodite-enriched TF, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F45F2.11 Aff_F45F2.11 F45F2.11; 5J0; CE10536; WBGene00018483; WP:CE10536 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F45F2.13 Aff_F45F2.13 his-6; F45F2.13; 5J14; NM_072798; WBGene00001880 his-6 encodes an H3 histone. histone H3 F45F2.3 Aff_F45F2.3 his-5; F45F2.3; 5J15; NM_072799; WBGene00001879 his-5 encodes an H4 histone. histone H4 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F45F2.4 Aff_F45F2.4 his-7; F45F2.4; 5J13; NM_072797; WBGene00001881 his-7 encodes an H2A histone. histone H2A Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated F45F2.9 Aff_F45F2.9 F45F2.9; F45F2.9.1; F45F2.9.2; 5I990; CE33095; WBGene00018481; WP:CE33095 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen F45G2.4 Aff_F45G2.4 F45G2.4; 3O517; CE16047; WBGene00009732; WP:CE16047 F45G2.4 encodes an epsilon subunit of the coatomer (COPI) complex; in mass RNAi assays, F45G2.4 is required for larval viability, proper locomotion, and properly rapid growth. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F45G2.9 Aff_F45G2.9 F45G2.9; 3O526; CE16052; WBGene00009735; WP:CE16052 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F45H11.2 Aff_F45H11.2 ned-8; F45H11.2; 1K950; CE10552; NM_060316; WBGene00003587; WP:CE10552 The ned-8 gene encodes a ubiquitin-like protein that is required for both embryogenesis and terminal hypodermal differentiation. ubiquitin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F46B6.4 Aff_F46B6.4 F46B6.4; 5K258; CE05870; WBGene00009769; WP:CE05870 GTP-binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F46B6.6 Aff_F46B6.6 F46B6.6; 5K264; CE26974; WBGene00009771; WP:CE26974 initiation factor IF-2 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F46B6.7 Aff_F46B6.7 ztf-7; F46B6.7; F46B6.7.1; F46B6.7.2; 5K268; CE05873; WBGene00009772; WP:CE05873 Zinc finger, C2H2 type McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F46C5.9 Aff_F46C5.9 F46C5.9; 2J100; CE10584; WBGene00009784; WP:CE10584 G-protein ViswanathanM et al 2005 S2 sir-2.1 regulated F46C8.3 Aff_F46C8.3 F46C8.3; CE28334; WBGene00018485; WP:CE28334; XI145 ViswanathanM et al 2005 S2 sir-2.1 regulated F46E10.10 Aff_F46E10.D F46E10.10; F46E10.10b.1; F46E10.10b.2; F46E10.10c.1; F46E10.10c.2; F46E10.D; F46E10.I; 5G996; CE20820; CE33096; CE33097; WBGene00018491; WP:CE20820; WP:CE33096; WP:CE33097 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Link et al 2003 T2 Abeta repressed, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F46E10.2 Aff_F46E10.C, Aff_F46E10.J F46E10.2; F46E10.2.1; F46E10.2.2; F46E10.C; F46E10.H; F46E10.J; 5H1; CE20813; WBGene00018489; WP:CE20813 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Zhang et al 2002, T1 mec-3 dependent genes F46E10.9 Aff_F46E10.E dpy-11; F46E10.9; F46E10.9.1; F46E10.9.2; F46E10.9.3; F46E10.E; 5G992; CE20819; NM_072254; WBGene00001073; WP:CE20819 dpy-11 encodes a membrane- associated thioredoxin- like (TRX) protein that affects body shape and ray morphology; the TRX domain displays catalytic activity in vitro, and dpy-11 is expressed in cytoplasm of hypodermis. thioredoxin Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F46F11.4 Aff_F46F11.4 ubl-5; F46F11.4; 1G176; CE10602; NM_059239; WBGene00006726; WP:CE10602 This gene encodes an ortholog of the human ubiquitin-like gene UBL5, which is a distinct cytoplasmic paralog of nuclear ubiquitin or ubiquitin-like proteins. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F46F11.5 Aff_F46F11.5 vha-10; F46F11.5; F46F11.5.1; F46F11.5.2; F46F11.5.3; 1G178; CE10604; NM_059240; WBGene00006919; WP:CE10604 vacuolar ATPase G subunit McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol F46F3.1 Aff_F46F3.1 ceh-27; F46F3.1; 5M140; CE36695; NM_073551; WBGene00000449; WP:CE36695 ceh-27 encodes a homeodomain protein of the NK-2 class that contains Drosophila scarecrow and human NKX-2 (OMIM:606727); CEH-27 activity is essential for embryogenesis and appears to be required for maintaining hypodermal integrity during movement as embryos lacking CEH-27 burst at a breach in the ventral hypodermis upon commencement of muscle contractions; CEH-27 expression is first detected in the ~100-cell embryo in what appear to be MS-derived cells while in later embryos expression is seen in a number of cells in the anterior head region. homeobox protein (NK-2 subfamily) ViswanathanM et al 2005 S2 sir-2.1 regulated F46F3.4 Aff_F46F3.4 ape-1; F46F3.4; 5M165; CE19874; NM_073554; WBGene00000146; WP:CE19874 P53-binding protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F46F5.9 Aff_F46F5.9 F46F5.9; 2B110; CE19425; WBGene00018500; WP:CE19425 Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F46F6.2 Aff_F46F6.2 F46F6.2; CE31703; NM_077341; WBGene00009793; WP:CE31703; XL19 Protein kinase C terminal domain Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F46H5.3 Aff_F46H5.3 F46H5.3; F46H5.3b.1; F46H5.3b.2; F46H5.3b.3; CE33098; CE37112; WBGene00018519; WP:CE33098; WP:CE37112; XH850 arginine kinase Golden et al 2004, N2 vs daf-2 different genes at , McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 LateList F46H5.4 Aff_F46H5.4 F46H5.4; CE04590; WBGene00018520; WP:CE04590; XH864 Rat trg gene product McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol F46H6.2 Aff_F46H6.2 dgk-2; F46H6.2; F46H6.2b.1; F46H6.2b.2; F46H6.2b.3; CE34027; CE34028; CE34029; WBGene00000959; WP:CE34027; WP:CE34028; WP:CE34029; XF114 dgk-2 encodes a putative diacylglycerol kinase. Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F47B10.1 Aff_F47B10.1 F47B10.1; F47B10.1.1; F47B10.1.2; CE03351; SCB1; WBGene00009812; WP:CE03351; XL516 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. succinate-CoA ligase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F47B10.9 Aff_F47B10.9 F47B10.9; CE03359; WBGene00009820; WP:CE03359; XL530 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F47B7.1 Aff_F47B7.1 F47B7.1; F47B7.1.1; F47B7.1.2; CE02743; WBGene00018532; WP:CE02743; XE407 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination F47B7.2 Aff_F47B7.2 F47B7.2; CE04599; CE28394; CE28395; WBGene00018533; WP:CE04599; WP:CE28394; WP:CE28395; XE395 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F47D12.3 Aff_F47D12.3 F47D12.3; 3H389; CE01947; WBGene00018560; WP:CE01947 ViswanathanM et al 2005 S2 sir-2.1 regulated F47D12.4 Aff_F47D12.4 hmg-1.2; son-1; F47D12.4; 3H371; CE26923; CE28233; CE28234; NM_065974; WBGene00001972; WP:CE26923; WP:CE28233; WP:CE28234 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F47D12.5 Aff_F47D12.5 F47D12.5; 3H372; CE01949; WBGene00018561; WP:CE01949 Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F47D12.6 Aff_F47D12.6 F47D12.6; 3H376; CE01950; WBGene00018562; WP:CE01950 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F47G4.2 Aff_F47G4.2 F47G4.2; 1O670; CE19875; WBGene00009823; WP:CE19875 Leucine Rich Repeat (2 copies) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma F47G4.4 Aff_F47G4.4 F47G4.4; F47G4.4.1; F47G4.4.2; 1O656; CE18702; WBGene00009825; WP:CE18702 F47G4.4 encodes a paralog of MEI-2 that, like MEI-2, binds MEI-1 in vitro; F47G4.4 might thus be an alternative ligand of MEI-1 in vivo. F47H4.1 Aff_F47H4.1 F47H4.1; 5R830; CE16062; WBGene00009834; WP:CE16062 Zinc finger, C2H2 type (2 domains) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E F48A11.4 Aff_F48A11.4 F48A11.4; 2A502; CE32668; WBGene00018585; WP:CE32668 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F48B9.8 Aff_F48B9.8 F48B9.8; CE04616; WBGene00018593; WP:CE04616; XC790 F48C1.6 Aff_F48C1.6 F48C1.6; 1F886; CE10742; WBGene00018599; WP:CE10742 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F48D6.1 Aff_F48D6.1 taf-11.1; F48D6.1; F48D6.1.1; F48D6.1.2; TAF7.1; CE07258; NM_076326; WBGene00006393; WP:CE07258; XE875 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F48E3.3 Aff_F48E3.3 F48E3.3; CE02751; WBGene00018604; WP:CE02751; XI114 killer toxin-resistance protein (S. cerevisiae) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F48E8.3 Aff_F48E8.3 F48E8.3; F48E8.3.1; F48E8.3.2; F48E8.3.3; F48E8.3.4; 3G553; CE36546; WBGene00018610; WP:CE36546 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. fumarate reductase flavoprotein McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated F48E8.5 Aff_F48E8.5 PP2A-A; paa-1; F48E8.5; F48E8.5.1; F48E8.5.2; F48E8.5.3; F48E8.5.4; 3G541; CE30997; NM_065761; WBGene00003901; WP:CE30997 paa-1 encodes a homolog of PR65, the structural subunit of protein phosphatase 2A (PP2A); PAA-1 protein is bound by SMG-5; PAA-1 is required in mass RNAi assays for embryonic viability, fertility, and cuticular integrity. Protein phosphatase 2A McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F48F7.4 Aff_F48F7.4 pqn-39; F48F7.4; CE05891; NM_077924; WBGene00004126; WP:CE05891; XO584 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). ViswanathanM et al 2005 S2 sir-2.1 regulated F48F7.6 Aff_F48F7.6 F48F7.6; F48F7.6.1; F48F7.6.2; CE05893; WBGene00009851; WP:CE05893; XO597 F49C12.11 Aff_F49C12.11 F49C12.11; F49C12.11.1; F49C12.11.2; 4K83; CE03371; WBGene00009880; WP:CE03371 ViswanathanM et al 2005 S2 sir-2.1 regulated F49C12.12 Aff_F49C12.12 phi-62; F49C12.12; F49C12.12.1; F49C12.12.2; 4K84; CE03372; WBGene00009881; WP:CE03372 ViswanathanM et al 2005 S2 sir-2.1 regulated F49C12.9 Aff_F49C12.9 F49C12.9; 4K80; CE10780; WBGene00009878; WP:CE10780 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F49E7.1 Aff_C05D9.6 rme-6; F49E7.1; CE26468; CE38712; WBGene00004377; WBGene00018633; WP:CE26468; WP:CE38712; XB721 The primary phenotype of rme-6 animals is an accumulation of secreted GFP in the pseudocoelom, suggesting a decrease in, or the absence of, endocytosis in coelomocytes. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F49E8.1 Aff_F49E8.1 F49E8.1; 4I323; CE33650; WBGene00018635; WP:CE33650 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F49E8.3 Aff_F49E8.3 pam-1; F49E8.3; F49E8.3a.1; F49E8.3a.2; F49E8.3a.3; 4I310; CE10790; CE37649; NM_068819; WBGene00003914; WP:CE10790; WP:CE37649 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Zhang et al 2002, T1 mec-3 dependent genes F49E8.5 Aff_F49E8.5 dif-1; F49E8.5; F49E8.5.1; F49E8.5.2; 4I316; CE28408; NM_068822; WBGene00000996; WP:CE28408 dif-1 encodes a putative mitochondrial solute carrier, orthologous to human SLC25A20 (OMIM:212138, mutated in carnitine-acylcarnitine translocase deficiency) that is required for the maintenance of embryonic tissue differentiation and viability; expressed throughout development and in the intestinal cells and hypodermis of the embryo. mitochondrial carrier family Golden et al 2004, daf-2 differentially expressed , Golden et al 2004, N2 vs daf-2 age different gene, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 LateList F49H12.1 Aff_F49H12.I lsy-2; F49H12.1; F49H12.1b.1; F49H12.1b.2; CE28437; CE38521; NM_075984; WBGene00003087; WP:CE28437; WP:CE38521; XC711 C2H2-type zinc finger protein ViswanathanM et al 2005 S2 sir-2.1 regulated F52A8.5 Aff_F52A8.5 F52A8.5; F52A8.5.1; F52A8.5.2; 1H922; CE05912; WBGene00009918; WP:CE05912 F52A8.5 is orthologous to the human gene GLYCINE CLEAVAGE SYSTEM PROTEIN H (GCSH; OMIM:238330), which when mutated leads to glycine encephalopathy. glycine cleavage system H protein like ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F52B11.1 Aff_F52B11.1 F52B11.1; F52B11.1a.1; F52B11.1a.2; F52B11.1a.3; 4O847; CE33791; CE33792; WBGene00009924; WP:CE33791; WP:CE33792 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F52B11.3 Aff_F52B11.3 noah-2; phi-55; F52B11.3; F52B11.3.1; F52B11.3.2; 4O859; CE18723; WBGene00009926; WP:CE18723 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 F52B11.5 Aff_F52B11.5 F52B11.5; 4O866; CE18725; WBGene00009927; WP:CE18725 F52B11.6 Aff_F52B11.6 ins-34; F52B11.6; 4O871; CE39736; NM_070301; WBGene00002117; WP:CE39736 F52B5.2 Aff_F52B5.2 F52B5.2; 1I892; CE24993; WBGene00009921; WP:CE24993 serine/threonine kinase (2 domains) Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F52B5.5 Aff_F52B5.5 F52B5.5; F52B5.5a.1; F52B5.5a.2; F52B5.5b.1; F52B5.5b.2; 1I901; CE29805; CE38369; NM_059861; WBGene00000467; WP:CE29805; WP:CE38369 cep-1 encodes an ortholog of the human tumor suppressor p53 (OMIM:191170, mutated in Li-Fraumeni syndrome) that promotes DNA damage-induced apoptosis and is required for normal meiotic segregation in the germ line, and affects sensitivity to hypoxia-induced lethality and longevity in response to starvation; CEP-1 is expressed ubiquitously in embryos and in the nucleoli of a subset of pharyngeal cells. Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster E, Wang et al 2003 S6 removed genes of contamination F52B5.6 Aff_F52B5.6 rpl-25.2; F52B5.6; F52B5.6.1; F52B5.6.2; 1I906; CE05721; NM_059862; WBGene00004439; WP:CE05721 rpl-25.2 encodes a large ribosomal subunit L23a protein. 60S ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated F52C12.1 Aff_F52C12.1 F52C12.1; F52C12.1.1; F52C12.1.2; 4C727; CE19434; WBGene00018678; WP:CE19434 Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F52C9.8 Aff_F52C9.4 pqe-1; F52C9.8; F52C9.8d.1; F52C9.8d.2; 3G411; CE30672; CE30673; CE30674; CE30675; CE30802; CE30998; CE39256; NM_065734; NM_065735; NM_065736; NM_171119; NM_171120; NM_171864; WBGene00004095; WP:CE30672; WP:CE30673; WP:CE30674; WP:CE30675; WP:CE30802; WP:CE30998; WP:CE39256 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes F52D1.1 Aff_F52D1.1 F52D1.1; CE38522; WBGene00018682; WP:CE38522; XB85 acid alpha-glucosidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F52D10.2 Aff_F52D10.2 F52D10.2; CE03388; WBGene00009930; WP:CE03388; XM208 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F52D10.3 Aff_F52D10.3 ftt-2; F52D10.3; F52D10.3a.1; F52D10.3a.2; F52D10.3b.1; F52D10.3b.2; CE03389; CE36489; NM_077537; NM_077538; WBGene00001502; WP:CE03389; WP:CE36489; XM222 14-3-3 protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, IVb male soma enriched genes F52D2.6 Aff_F52D2.6 F52D2.6; CE20842; WBGene00018688; WP:CE20842; XC601 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol F52E10.1 Aff_F52E10.1 egl-16; sdc-1; F52E10.1; CE03393; NM_078249; WBGene00004745; WP:CE03393; XQ895 sdc-1 encodes a zinc-finger protein of the C2H2-type that affects egg laying and vulval development, and hermaphrodite sex determination; expressed at highest levels in embryos and in adults. Zinc finger, C2H2 type (3 domains) Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E F52E4.1 Aff_F52E4.1 F52E4.1; F52E4.1a.1; F52E4.1a.2; CE07269; CE30139; WBGene00018701; WP:CE07269; WP:CE30139; XD709 F52E4.1 is orthologous to the human gene PROPIONYL-CoA CARBOXYLASE, BETA SUBUNIT (PCCB; OMIM:232050), which when mutated leads to propionicacidemia; F52E4.1 protein is predicted to be mitochondrial. ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Zhang et al 2002, T1 mec-3 dependent genes F52E4.7 Aff_F52E4.7 F52E4.7; CE10836; WBGene00018703; WP:CE10836; XD714 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F52F12.6 Aff_F52F12.6 ekl-2; F52F12.6; 1K482; CE24995; WBGene00009939; WP:CE24995 C2HC type zinc finger protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F52F12.7 Aff_F52F12.7 F52F12.7; 1K507; CE10852; WBGene00009940; WP:CE10852 F52F12.7 is orthologous to the human gene STEROIDOGENIC ACUTE REGULATORY PROTEIN (STAR; OMIM:600617), which when mutated leads to disease. steroidogenic acute regulatory protein like Kwon et al 2004 T1 late-induction Ethanol-response, ViswanathanM et al 2005 S2 sir-2.1 regulated F52G3.4 Aff_F52G3.4 F52G3.4; CE10860; WBGene00018712; WP:CE10860; XR560 F52H2.7 Aff_F52H2.7 F52H2.7; CE31179; WBGene00018719; WP:CE31179; XD186 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol F52H3.2 Aff_F52H3.2 F52H3.2; 2K322; CE03398; WBGene00009944; WP:CE03398 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. glucose inhibited division protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F52H3.3 Aff_F52H3.3 bath-38; F52H3.3; 2K334; CE03399; WBGene00009945; WP:CE03399 BTB (also known as BR-C/Ttk) domain. F53A2.2 Aff_F53A2.2 sdz-20; F53A2.2; 3O425; CE16094; WBGene00009950; WP:CE16094 Jones et al 2001 Dauer specific genes P<0.05, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F53A2.3 Aff_F53A2.3 F53A2.3; 3O426; CE16095; WBGene00009951; WP:CE16095 ViswanathanM et al 2005 S2 sir-2.1 regulated F53A2.4 Aff_F53A2.4 nud-1; F53A2.4; 3O429; CE16096; NM_067348; WBGene00003829; WP:CE16096 nud-1 encodes the C. elegans ortholog of the Aspergillus nidulans nudC, which mediates nuclear migration along Aspergillus hyphae. Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F53A2.6 Aff_F53A2.6 ife-1; F53A2.6; F53A2.6.1; F53A2.6.2; F53A2.6.3; 3O433; CE31809; NM_067350; WBGene00002059; WP:CE31809 The ife-1 gene encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; it is specifically required for spermatogenesis, and is expressed in P granules. EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (EIF-4E) (EIF4E) (MRNA CAP-BINDING PROTEIN) (EIF-4F 25 KD SUBUNIT) Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F53A2.7 Aff_F53A2.7 F53A2.7; F53A2.7.1; F53A2.7.2; F53A2.7.3; 3O435; CE16099; WBGene00009952; WP:CE16099 Thiolases McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F53A3.3 Aff_F53A3.3 rps-22; F53A3.3; F53A3.3.1; F53A3.3.2; F53A3.3.3; 3D39; CE10884; NM_065080; WBGene00004491; WP:CE10884 rps-22 encodes a small ribosomal subunit S15a protein. 40S ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F53A3.4 Aff_F53A3.4 pqn-41; F53A3.4; 3D27; CE28443; NM_065077; WBGene00004128; WP:CE28443 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Jones et al 2001 Dauer specific genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F53B3.1 Aff_F53B3.1 F53B3.1; CE28444; WBGene00018740; WP:CE28444; XD472 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F53B3.5 Aff_F53B3.4, Aff_F53B3.5 F53B3.5; CE30142; WBGene00018743; WP:CE30142; XD492 F53B3.5 encodes a claudin homolog that may regulate ion channels; F53B3.5 is distantly similar to mammalian voltage-dependent calcium channel gamma subunits that are known or suspected to prevent epilepsy in vivo (e.g., stargazin; MGI:1316660); F53B3.5 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F53B7.3 Aff_F53B7.3 F53B7.3; 5L480; CE05922; WBGene00009966; WP:CE05922 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F53C11.3 Aff_F53C11.3 F53C11.3; 5O263; CE10908; WBGene00009973; WP:CE10908 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. 2,4-dienoyl-CoA reductase ViswanathanM et al 2005 S2 sir-2.1 regulated F53C11.4 Aff_F53C11.4 F53C11.4; F53C11.4.1; F53C11.4.2; 5O266; CE17853; WBGene00009974; WP:CE17853 ViswanathanM et al 2005 S2 sir-2.1 regulated F53C11.7 Aff_F53C11.7 swan-2; tag-206; F53C11.7; F53C11.7.1; F53C11.7.2; F53C11.7.3; 5O282; CE24997; WBGene00009976; WP:CE24997 Yeast hypothetical protein YPL247C like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F53C11.8 Aff_F53C11.8 swan-1; F53C11.8; F53C11.8.1; F53C11.8.2; 5O286; CE10918; WBGene00009977; WP:CE10918 Yeast hypothetical protein YPL247C like Reinke et al 2004, list of genes in cluster order F53E10.1 Aff_F53E10.1 F53E10.1; F53E10.1.1; F53E10.1.2; 5D95; CE10920; WBGene00018758; WP:CE10920 F53E10.6 Aff_F53E10.6 F53E10.6; F53E10.6.1; F53E10.6.2; 5D80; CE10930; WBGene00018762; WP:CE10930 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F53E2.1 Aff_F53E2.A tag-304; F53E2.1; F53E2.A; 5B949; CE30280; WBGene00018757; WP:CE30280 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F53F10.2 Aff_F53F10.2 F53F10.2; F53F10.2a.1; F53F10.2a.2; F53F10.2a.3; F53F10.2b.1; F53F10.2b.2; F53F10.2b.3; F53F10.2b.4; 1E401; CE10982; CE30374; WBGene00018764; WP:CE10982; WP:CE30374 decarbaxylase ViswanathanM et al 2005 S2 sir-2.1 regulated F53F10.4 Aff_F53F10.4 rab-2; unc-108; F53F10.4; F53F10.4.1; F53F10.4.2; 1E393; CE10986; NM_058832; WBGene00006833; WP:CE10986 unc-108 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; the precise biological role and expression pattern of unc-108 are not yet known. RAS-related protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F53F10.5 Aff_F53F10.5 npp-11; F53F10.5; F53F10.5.1; F53F10.5.2; 1E389; CE10988; NM_058831; WBGene00003797; WP:CE10988 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F53F4.11 Aff_F53F4.11 F53F4.11; F53F4.11.1; F53F4.11.2; 5O104; CE20849; WBGene00009993; WP:CE20849 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F53F4.14 Aff_F53F4.14 F53F4.14; F53F4.14.1; F53F4.14.2; 5O109; CE29593; WBGene00009996; WP:CE29593 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E F53F4.3 Aff_F53F4.3 F53F4.3; 5O73; CE10958; WBGene00009987; WP:CE10958 S.pombe hypothetical protein SPAC4G9.01 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E F53F8.3 Aff_F53F8.3 F53F8.3; 5V158; CE17857; WBGene00010000; WP:CE17857 Zinc finger, C3HC4 type (RING finger) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F53G12.10 Aff_F53G12.10 rpl-7; F53G12.10; F53G12.10.1; F53G12.10.2; 1A583; CE11024; NM_058275; WBGene00004418; WP:CE11024 rpl-7 encodes a large ribosomal subunit L7 protein required in mass RNAi assays for embryonic viability and normally rapid growth. ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F53G2.7 Aff_F53G2.7 mnat-1; F53G2.7; F53G2.7.1; F53G2.7.2; 2C764; CE31957; WBGene00018769; WP:CE31957 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F53H1.1 Aff_Y104H12B_374.A F53H1.1; 4C62; CE27427; WBGene00018776; WP:CE27427 helicase Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F53H1.3 Aff_F58F6.7 F53H1.3; 4C103; CE31538; WBGene00018777; WP:CE31538 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F53H1.4 Aff_F53H1.4 F53H1.4; 4C91; CE31539; CE33651; CE33652; WBGene00018778; WP:CE31539; WP:CE33651; WP:CE33652 F53H4.3 Aff_F53H4.3 F53H4.3; CE11032; WBGene00010008; WP:CE11032; XQ504 ViswanathanM et al 2005 S2 sir-2.1 regulated F53H8.1 Aff_F53H8.1 apm-3; apt-7; F53H8.1; CE35723; NM_075783; WBGene00000164; WP:CE35723; XB573 apt-7 gene encodes an adaptin, orthologous to the mu3 subunit of adaptor protein complex 3 (AP-3); APT-7 is also orthologous to human HPS, which when mutated leads to Hermansky-Pudlak syndrome (OMIM:203300); based on structural similarity, APT-7 may be involved in the formation of intracellular transport vesicles. clathrin coat assembly protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F53H8.2 Aff_F53H8.2 arr-1; F53H8.2; CE28831; NM_075782; WBGene00000195; WP:CE28831; XB571 arr-1 encodes the C. elegans beta-arrestin ortholog (OMIM:107940, 107941, mice lacking beta-arrestin family members display defects in G protein-coupled receptor desensitization); by homology, ARR-1 is predicted to be a multifunctional adaptor protein that interacts with intracellular signaling molecules as well as activated and phosphorylated G protein-coupled and TGF-beta receptors to: 1) downregulate receptor signaling, 2) promote receptor endocytosis, and 3) activate MAP kinase- and Src-dependent signaling pathways; in C. elegans, loss of arr-1 function via mutation or RNAi does not result in any obvious abnormalities and, in particular, does not appear to affect chemosensation or odorant discrimination; however, animals doubly mutant for arr-1 and grk-2, which encodes a G protein-coupled receptor kinase, are sick and slow growing; an arr-1 transcriptional reporter is expressed in neurons, including the ASH chemosensory neurons, and in the intestine beta-arrestin Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F53H8.4 Aff_F53H8.4 sms-2; F53H8.4; CE04657; NM_075781; WBGene00004893; WP:CE04657; XB564 F54A5.1 Aff_C54G6.4 F54A5.1; F54A5.1.1; F54A5.1.2; F54A5.E; 1B465; CE20859; WBGene00018786; WP:CE20859 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F54B11.3 Aff_F54B11.3 unc-84; F54B11.3; CE27761; CE28236; WBGene00006816; WP:CE27761; WP:CE28236; XO207 unc-84 encodes a transmembrane protein that contains a SUN domain with homology to S. pombe Sad1 and affects nuclear migration and anchoring of various cell types together with UNC-83 and ANC-1, thereby affecting coordinated locomotion, vulval formation, and egg laying; UNC-84 is localized to the nuclear envelope and requires LMN-1 for this localization, and it is expressed in the nuclear envelope of essentially all adult and embryonic cells. ViswanathanM et al 2005 S2 sir-2.1 regulated F54B11.6 Aff_F54B11.6 bra-1; F54B11.6; CE05930; NM_077876; WBGene00000262; WBGene00010029; WP:CE05930; XO217 The bra-1 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1) that negatively regulates the DAF-1/DAF-7/DAF-14 TGF-beta signalling pathway. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F54C4.4 Aff_F54C4.4 F54C4.4; 3A704; CE19893; WBGene00018795; WP:CE19893 F54C8.3 Aff_F54C8.3 apc-4; emb-30; F54C8.3; 3K526; CE32676; NM_066673; WBGene00001284; WP:CE32676 emb-30 encodes an anaphase-promoting complex/cyclosome (APC/C) component orthologous to mammalian APC-4 and Schizosaccharomyces pombe Lid1; EMB-30 is required for the metaphase-to-anaphase transition during meiosis and mitosis, for establishing anterior-posterior polarity in the early embryo, and for proper localization of germline granules and the maternally provided PAR-2 and PAR-3 proteins. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F54C8.4 Aff_F54C8.4 F54C8.4; 3K532; CE00190; WBGene00010037; WP:CE00190 Protein-tyrosine phosphatase Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F54C9.5 Aff_F54C9.5 rpl-5; F54C9.5; F54C9.5.1; F54C9.5.2; 2I861; CE02255; NM_063410; WBGene00004416; WP:CE02255 rpl-5 encodes a large ribosomal subunit L5 protein; by homology, RPL-5 is predicted to function in protein biosynthesis; in C. elegans RPL-5 activity is broadly required for embryonic, larval, germline, and vulval development, as well as normal body coloration, morphology, and postembryonic growth rates. 60S ribosomal protein L5 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F54C9.9 Aff_F54C9.9 F54C9.9; 2I871; CE20865; WBGene00010044; WP:CE20865 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F54D10.1 Aff_F54D10.1 skr-15; F54D10.1; 2E115; CE19451; NM_062261; WBGene00004821; WP:CE19451 The skr-15 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-15(RNAi) animals are at least superficially normal. Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F54D10.2 Aff_F54D10.2 fbxa-24; F54D10.2; 2E107; CE32677; WBGene00018803; WP:CE32677 Lund et al 2002 Fig1 aging-regulated genes, Lund et al 2002 Fig4 Mount 15, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F54D11.1 Aff_F54D11.1 F54D11.1; 5F113; CE11068; WBGene00018811; WP:CE11068 ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F54D5.12 Aff_Y62F5A.B F54D5.12; F54D5.12.1; F54D5.12.2; 2L830; CE26814; WBGene00010055; WP:CE26814 yeast hyothetical YET1 like protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F54D5.7 Aff_F54D5.7 F54D5.7; F54D5.7.1; F54D5.7.2; CE03411; NM_064068; WBGene00010052; WP:CE03411 The F54D5.7 gene encodes an ortholog of the human gene GLUTARYL-COENZYME A DEHYDROGENASE (GCDH), which when mutated leads to glutaricaciduria type I (OMIM:231670). acyl-CoA dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F54D5.8 Aff_F54D5.8 dnj-13; F54D5.8; 2L839; CE03412; NM_064067; WBGene00001031; WP:CE03412 This gene encodes a protein containing a DnaJ ('J') domain. DNAJ protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F54D7.2 Aff_F54D7.2 F54D7.2; 1F377; CE36936; WBGene00018797; WP:CE36936 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F54D8.1 Aff_F54D8.1 dpy-17; F54D8.1; F54D8.1.1; F54D8.1.2; 3G197; CE11066; NM_065685; WBGene00001076; WBGene00018799; WP:CE11066 Uncloned locus that affects body length and outgrowth of posterior canal cell processes. Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F54D8.3 Aff_F54D8.3 alh-1; F54D8.3; F54D8.3a.1; F54D8.3a.2; F54D8.3b.1; F54D8.3b.2; F54D8.3b.3; 3G169; CE29809; CE32434; NM_065680; NM_181921; WBGene00000107; WP:CE29809; WP:CE32434 alh-1 is orthologous to the human gene ALDEHYDE DEHYDROGENASE 2, MITOCHONDRIAL (ALDH2; OMIM:100650), in which a polymorphism can lead to acute ethanol intolerance. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F54E12.1 Aff_F54E12.1 his-55; F54E12.1; 4M102; NM_069737; WBGene00001929 his-55 encodes an H3 histone; by homology, HIS-55 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-55 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV. histone H3 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F54E12.2 Aff_F54E12.2 F54E12.2; F54E12.2.1; F54E12.2.2; 4M98; CE11083; WBGene00010061; WP:CE11083 helicase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F54E12.4 Aff_F54E12.4 his-58; F54E12.4; 4M104; NM_069739; WBGene00001932 his-58 encodes an H2B histone. histone H2B ViswanathanM et al 2005 S2 sir-2.1 regulated, Zhang et al 2002, T1 mec-3 dependent genes F54E7.1 Aff_F54E7.1 F54E7.1; 3G771; CE01312; WBGene00018827; WP:CE01312 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Transporters, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F54E7.2 Aff_F54E7.2 rps-12; F54E7.2; F54E7.2.1; F54E7.2.2; 3G769; CE26896; NM_065820; WBGene00004481; WP:CE26896 rps-12 encodes a small ribosomal subunit S12 protein; by homology, RPS-12 is predicted to function in protein biosynthesis; in C. elegans, RPS-12 activity is required for embryonic and germline development, normal movement, and the overall health of the animal. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F54E7.3 Aff_F54E7.3 par-3; F54E7.3; 3G765; CE28449; CE28450; CE39941; NM_065816; WBGene00003918; WP:CE28449; WP:CE28450; WP:CE39941 par-3 encodes a PDZ domain-containing protein orthologous to mammalian atypical PKC isotype-specific interacting protein (ASIP) and Drosophila Bazooka; PAR-3 is required maternally for polarization of the zygote along the anterior-posterior (A-P) axis; PAR-3, PAR-6, and PKC-3 form a complex that localizes to the anterior cytoplasmic cortex of the one- and two-cell embryo; this localization is regulated spatially by PAR-2, which segregates to the posterior cortex. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F54F2.2 Aff_F54F2.2 zfp-1; zpf-1; F54F2.2; F54F2.2a.1; F54F2.2a.2; F54F2.2a.3; F54F2.2c.1; F54F2.2c.2; 3J897; CE25003; CE26933; CE33653; WBGene00006975; WP:CE25003; WP:CE26933; WP:CE33653 zfp-1 encodes a leucine zipper, zinc finger, and PHD/LAP domain (plant homeodomain/leukemia-associated protein)-containing protein homologous to human AF10 (OMIM:602409, which is involved in chromosomal translocations associated with acute leukemia); loss of zfp-1 activity via RNA-mediated interference (RNAi) results in suppression of RNAi, suggesting that ZFP-1 plays a role in gene silencing; based on sequence similarity, ZFP-1 is predicted to associate with chromatin. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F54F3.4 Aff_F54F3.4 F54F3.4; 5N403; CE19894; WBGene00010063; WP:CE19894 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. dehydrogenase Wang et al 2003 S6 removed genes of contamination F54F7.1 Aff_F54F7.1 TAF-8.1; taf-7.1; F54F7.1; CE03416; NM_077575; WBGene00006388; WP:CE03416; XM454 The taf-7.1 gene encodes an ortholog of mammalian TATA-binding protein associated factor TAF7L (TAFIIQ, OMIM:300314) that in mice exhibits testis-specific expression; TAF-7 function in C. elegans is not yet known, as taf-7 inactivation by RNA interference does not result in any obvious developmental defects. McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma F54F7.6 Aff_F54F7.6 F54F7.6; CE03421; WBGene00010066; WP:CE03421; XM483 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F54G8.3 Aff_F54G8.3 ina-1; F54G8.3; 3K258; CE00205; NM_066631; WBGene00002081; WP:CE00205 Integrin alpha chain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F55A11.3 Aff_F55A11.3 F55A11.3; F55A11.3.1; F55A11.3.2; 5M249; CE05945; WBGene00010076; WP:CE05945 Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F55A12.2 Aff_F55A12.2 F55A12.2; F55A12.2d.1; F55A12.2d.2; 1F933; CE29396; CE30540; CE34317; CE34318; WBGene00018863; WP:CE29396; WP:CE30540; WP:CE34317; WP:CE34318 ViswanathanM et al 2005 S2 sir-2.1 regulated F55A12.4 Aff_F55A12.4 dhs-2; F55A12.4; 1F923; CE11123; CE26924; CE33397; NM_059174; NM_182014; NM_182015; WBGene00000966; WP:CE11123; WP:CE26924; WP:CE33397 dhs-2 encodes a short-chain dehydrogenase predicted to be mitochondrial. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F55A12.7 Aff_F55A12.7 apm-1; F55A12.7; 1F912; CE30145; NM_059171; WBGene00000150; WP:CE30145 The apm-1 gene encodes an adaptin: specifically, it encodes an ortholog of the mu1-II subunit of adaptor protein complex 1 (AP-1). clathrin coat assembly protein complex 1 medium chain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol F55A12.8 Aff_F55A12.8 F55A12.8; F55A12.8.1; F55A12.8.2; F55A12.8.3; 1F918; CE11131; WBGene00018866; WP:CE11131 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes F55A3.3 Aff_F55A3.3 phi-16; F55A3.3; 1L369; CE17113; WBGene00018849; WP:CE17113 transcritpion factor McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F55A4.1 Aff_F55A4.1 F55A4.1; F55A4.1.1; F55A4.1.2; CE19895; WBGene00018853; WP:CE19895; XB655 vesicle trafficking protein sec22b McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F55A8.1 Aff_F55A8.1 egl-18; elt-5; pvl-3; F55A8.1; F55A8.1.1; F55A8.1.2; F55A8.1.3; 4C681; CE28339; NM_067742; WBGene00001186; WP:CE28339 egl-18 encodes a member of the GATA-family of transcription factors that affects cell migration, cell fate specification; expressed in the head, in hypodermal seam cells, VC neurons, and vulval precursor cells. zinc finger protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F55B12.4 Aff_F55B12.4 F55B12.4; F55B12.4.1; F55B12.4.2; F55B12.4.3; CE26815; WBGene00010089; WP:CE26815 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. poly(A) polymerase like Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset F55C5.4 Aff_F55C5.4 F55C5.4; 5M755; CE11156; WBGene00010093; WP:CE11156 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol F55C5.5 Aff_F55C5.5 EF-TS; tsfm-1; F55C5.5; 5M750; CE11158; WBGene00010094; WP:CE11158 F55C5.5 encodes a translational elongation factor Ts (EF-Ts) that binds two different EF-Tu proteins (EF-TU1/Y71H2AM.23 and EF-TU2/C43E11.4) in vitro, stimulating guanine-nucleotide exchange and mRNA translation; F55C5.5 is predicted to be mitochondrial and has a putative N-terminal transit peptide sequence; F55C5.5 is required in mass RNAi assays for normally rapid growth and for maintenance of the germline. mitochondrial elongation factor TS McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, GO categories, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F55C5.8 Aff_F55C5.8 F55C5.8; 5M770; CE20875; WBGene00010097; WP:CE20875 signal recognition particle 68 KD protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F55C9.8 Aff_F55C9.8 fbxb-62; F55C9.8; 5T772; CE18740; WBGene00010105; WP:CE18740 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 daf-16 Resveratrol F55D10.2 Aff_F55D10.2 rpl-25.1; F55D10.2; F55D10.2.1; F55D10.2.2; CE02777; NM_076407; WBGene00004438; WP:CE02777; XF335 rpl-25.1 encodes a large ribosomal subunit L23a protein. Ribosomal protein L23 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F55D10.3 Aff_F55D10.3 glit-1; F55D10.3; CE04659; NM_076406; WBGene00018878; WP:CE04659; XF333 Esterase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F55F3.1 Aff_F55F3.1 aakb-1; F55F3.1; F55F3.1.1; F55F3.1.2; CE18744; WBGene00010115; WP:CE18744; XO377 Golden et al 2004, N2 vs daf-2 different genes at , Golden et al 2004, N2 vs daf-2 age different gene, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol F55F8.3 Aff_F55F8.3 F55F8.3; 1G218; CE30542; WBGene00018891; WP:CE30542 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F55F8.4 Aff_F55F8.4 tag-326; F55F8.4; F55F8.4.1; F55F8.4.2; F55F8.4.3; 1G222; CE11194; WBGene00018892; WP:CE11194 Jiang et al 2001 Fig1 hermaphrodite-enriched TF, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F55F8.5 Aff_F55F8.5 tag-345; F55F8.5; F55F8.5.1; F55F8.5.2; 1G224; CE11196; WBGene00018893; WP:CE11196 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F55G1.10 Aff_F55G1.10 his-61; F55G1.10; 4I250; NM_068800; WBGene00001935 his-61 encodes an H2A histone. Histone ViswanathanM et al 2005 S2 sir-2.1 regulated F55G1.2 Aff_F55G1.2 his-59; F55G1.2; 4I253; NM_068803; WBGene00001933 his-59 encodes an H3 histone; by homology, HIS-59 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-59 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV. Histone Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories F55G1.3 Aff_F55G1.3 his-62; F55G1.3; 4I251; NM_068801; WBGene00001936 his-62 encodes an H2B histone. Histone ViswanathanM et al 2005 S2 sir-2.1 regulated F55G1.4 Aff_F55G1.4 rod-1; F55G1.4; 4I249; CE07281; NM_068799; WBGene00018900; WP:CE07281 ViswanathanM et al 2005 S2 sir-2.1 regulated F55H12.5 Aff_F55H12.2 F55H12.5; 1J447; CE32441; WBGene00010136; WP:CE32441 Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, shared sperm F55H2.2 Aff_F55H2.2 vha-14; F55H2.2; F55H2.2.1; F55H2.2.2; 3K599; CE00209; NM_066693; WBGene00010130; WP:CE00209 Membrane-associated atpase gamma chain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56A3.2 Aff_F56A3.2 F56A3.2; 1F753; CE11216; WBGene00018909; WP:CE11216 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F56A4.12 Aff_F56A4.A, Aff_Y19D10A.F F56A4.12; 5C954; CE25010; WBGene00018920; WP:CE25010 ViswanathanM et al 2005 S2 sir-2.1 regulated F56A6.4 Aff_F56A6.4, Aff_Y65B4A_173.A, Aff_Y65B4A_175.A F56A6.4; 1B88; CE34319; WBGene00018923; WP:CE34319 ViswanathanM et al 2005 S2 sir-2.1 regulated F56A8.4 Aff_F56A8.4 F56A8.4; 3O353; CE16124; WBGene00010140; WP:CE16124 Jones et al 2001 Dauer specific genes P<0.05, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F56A8.5 Aff_F56A8.5 F56A8.5; 3O357; CE16125; WBGene00010141; WP:CE16125 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F56A8.8 Aff_F56A8.8 F56A8.8; 3O375; CE16128; WBGene00010142; WP:CE16128 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F56B3.8 Aff_F56B3.8 F56B3.8; 4B529; CE34320; WBGene00018932; WP:CE34320 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56B6.2 Aff_F56B6.2, Aff_F56B6.3 rgs-7; F56B6.2; CE29403; CE29404; CE30151; CE39019; NM_076209; WBGene00004350; WBGene00018936; WP:CE29403; WP:CE29404; WP:CE30151; WP:CE39019; XE175 F56B6.2 encodes three isoforms of an atypical regulator of G protein signaling (RGS) protein that contains both a C2 and an RGS domain, and that binds EGL-30 via both domains, similar in organization to mammalian PDZ-RGS3; the RGS domain has GTPase activator protein (GAP) activity in vitro on mammalian G[alphai]3; F56B6.2 thus may stably bind EGL-30 at all stages of EGL-30's GTPase cycle, might organize EGL-30 into a stable multiprotein signalling complex (with GTP[gamma]S), and might persistently inhibit EGL-30 when triggered by calcium or phospholipids; F56B6.2 has no obvious function in mass RNAi assays Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56C11.3 Aff_F56C11.3 F56C11.3; 1A656; CE17903; WBGene00018955; WP:CE17903 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F56C9.1 Aff_F56C9.1 CEGLC-7B; Ce-glc-7beta; gsp-2; F56C9.1; F56C9.1.1; F56C9.1.2; 3I433; CE01319; WBGene00001748; WP:CE01319 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F56C9.10 Aff_F56C9.10 F56C9.10; F56C9.10b.1; F56C9.10b.2; 3I420; CE01320; CE31003; WBGene00018953; WP:CE01320; WP:CE31003 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F56D1.3 Aff_F56D1.3 F56D1.3; F56D1.3.1; F56D1.3.2; CE29407; WBGene00018961; WP:CE29407 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56D1.4 Aff_F56D1.4 clr-1; F56D1.4; 2F767; CE32051; CE32052; CE32053; WBGene00000548; WP:CE32051; WP:CE32052; WP:CE32053 A receptor tyrosine phosphatase that negatively regulates the FGF receptorsignaling pathway; it localizes to the plasma membrane. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F56D2.2 Aff_F56D2.2 F56D2.2; 3G677; CE11228; WBGene00018964; WP:CE11228 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F56D2.6 Aff_F56D2.6 F56D2.6; F56D2.6b.1; F56D2.6b.2; 3G680; CE01334; CE32900; WBGene00018967; WP:CE01334; WP:CE32900 The F56D2.6 gene encodes a DEAH helicase orthologous to the Drosophila CG11107, the human DDX15, and the S. cerevisiae PRP43 proteins. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F56D5.5 Aff_F56D5.5 F56D5.5; 4K172; CE05961; WBGene00010149; WP:CE05961 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, list of genes in cluster E F56E10.4 Aff_F56E10.4 rps-27; F56E10.4; F56E10.4.1; F56E10.4.2; F56E10.4.3; F56E10.4.4; 5A582; CE19904; NM_070733; WBGene00004496; WP:CE19904 rps-27 encodes a small ribosomal subunit S27 protein. ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F56F11.4 Aff_F56F11.4 F56F11.4; 3D953; CE28467; CE31008; WBGene00018991; WP:CE28467; WP:CE31008 26S protease regulatory subunit Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E F56F3.2 Aff_F56F3.2 ndg-4; F56F3.2; 3F554; CE01015; CE33658; NM_065506; WBGene00003577; WP:CE01015; WP:CE33658 Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56F3.5 Aff_F56F3.5 rps-1; F56F3.5; F56F3.5.1; F56F3.5.2; 3F565; CE00664; NM_065509; WBGene00004470; WP:CE00664 rps-1 encodes a small ribosomal subunit S3A protein. Ribosomal protein S3a (human) homolog. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F56G4.3 Aff_F56G4.2 F56G4.3; 1L950; WBGene00010158 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F56G4.5 Aff_Y53H1C.A F56G4.5; F56G4.5.1; F56G4.5.2; 1L979; CE23786; WBGene00010160; WP:CE23786 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Thioredoxins McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F56H1.5 Aff_F56H1.5 F56H1.5; 1G338; CE17916; WBGene00018995; WP:CE17916 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F56H9.2 Aff_F56H9.2 F56H9.2; F56H9.2.1; F56H9.2.2; 5N119; CE05972; WBGene00010174; WP:CE05972 Lund et al 2002 Fig4 Mount 15, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56H9.5 Aff_F56H9.5 lin-25; F56H9.5; 5N137; CE05975; NM_073761; WBGene00003011; WP:CE05975 lin-25 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F57B10.10 Aff_F57B10.10 dad-1; F57B10.10; F57B10.10.1; F57B10.10.2; 1H132; CE11316; NM_059488; WBGene00000896; WP:CE11316 dad-1 encodes an ortholog of human DAD1 (OMIM:600243) that inhibits cell death and can functionally complement the hamster protein in cultured cells. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F57B10.11 Aff_F57B10.11 bag-1; F57B10.11; 1H140; CE11318; NM_059492; WBGene00000236; WP:CE11318 A homolog of the human BAG-family of co-chaperone proteins, negatively regulates Hsp70 and affects cell stress and cell growth. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F57B10.4 Aff_F57B10.4 F57B10.4; 1H143; CE11304; WBGene00019002; WP:CE11304 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F57B10.5 Aff_F57B10.5 F57B10.5; 1H139; CE11306; WBGene00019003; WP:CE11306 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F57B10.6 Aff_F57B10.6 F57B10.6; 1H135; CE11308; WBGene00019004; WP:CE11308 F57B10.6 is orthologous to the human gene EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 5 (XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G (COCKAYNE SYNDROME)) (ERCC5; OMIM:133530), which when mutated leads to disease. DNA repair protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F57B10.8 Aff_F57B10.8 F57B10.8; 1H124; CE11312; WBGene00019005; WP:CE11312 Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes i