Baugh et al 2003, subclass MDpd_66min, 153 genes Gene list file name: Baugh2003_classMDpd_66min.txt Type of gene identifier: Affymetrix custom chip Description: Baugh et al 2005, Supplymental Dataset, subclass MDpd_159min Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations AFF_R07E5.12 Aff_R07E5.12 AFF_T08D2.G Aff_T08D2.G AFF_Y13C8_223.D Aff_Y13C8_223.D B0001.4 Aff_B0001.4 B0001.4; 4M900; CE37307; WBGene00007089; WP:CE37307 uridine kinase like ViswanathanM et al 2005 S2 sir-2.1 regulated B0250.5 Aff_B0250.5 B0250.5; 5U965; CE18481; WBGene00007122; WP:CE18481 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. 3-HYDROXYISOBUTYRATE DEHYDROGENASE PRECURSOR (EC 1.1.1.31) (HIBADH) (FRAGMENT) Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 B0491.7 Aff_B0491.7 B0491.7; 2L641; CE02109; WBGene00007194; WP:CE02109 B0491.7 encodes a putative diphthine synthase orthologous to S. cerevisiae DPH5; DPH5 is an S-adenosylmethionine:EF-2 methyltransferase required for the enzymatic conversion of 3-amino-3-carboxypropyl-histidine to diphthine; DPH5 adds at least the last two of the three methyl groups present in diphthine, and is homologous to bacterial AdoMet:uroporphyrinogen III methyltransferases. diphthine synthase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA B0546.1 Aff_B0546.1 B0546.1; B0546.1.1; B0546.1.2; B0546.1.3; 4E151; CE16792; WBGene00015248; WP:CE16792 ATPase inhibitor ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C06A6.4 Aff_C06A6.4 C06A6.4; 4I592; CE35224; CE37607; WBGene00015509; WP:CE35224; WP:CE37607 aminoacylase-1 ViswanathanM et al 2005 S2 sir-2.1 regulated C08F8.3 Aff_C08F8.3 C08F8.3; 4L921; CE30596; WBGene00007445; WP:CE30596 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C14B1.6 Aff_C14B1.6 C14B1.6; 3E807; CE31415; WBGene00007577; WP:CE31415 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C15F1.6 Aff_C15F1.C art-1; C15F1.6; 2H262; CE20509; NM_063029; WBGene00000198; WP:CE20509 a protein similar to synaptic glycoprotein SC2 from mammals. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C15F1.7 Aff_C15F1.B sod-1; C15F1.7; C15F1.7b.1; C15F1.7b.2; C15F1.B; 2H264; CE20508; CE23550; NM_063030; WBGene00004930; WP:CE20508; WP:CE23550 The sod-1 gene encodes an ortholog of human SOD1 (OMIM:147450), which when mutated leads to amyotrophic lateral sclerosis (OMIM:105400). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C16A11.3 Aff_C16A11.3 C16A11.3; 2E523; CE19353; WBGene00015816; WP:CE19353 protein kinase Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C16A3.5 Aff_C16A3.5 C16A3.5; C16A3.5.1; C16A3.5.2; 3H471; CE04005; WBGene00015810; WP:CE04005 NADH-ubiquinone oxidoreductase B22 Lund et al 2002 Fig1 aging-regulated genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C16C10.11 Aff_C16C10.11 C16C10.11; C16C10.11.1; C16C10.11.2; 3F241; CE01491; WBGene00007630; WP:CE01491 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C16C8.11 Aff_C16C8.11 C16C8.11; 2D747; CE08222; WBGene00015849; WP:CE08222 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C18E3.5 Aff_C18E3.5 C18E3.5; 1E771; CE27713; WBGene00015974; WP:CE27713 beta transducin Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched C18F10.7 Aff_C18F10.7 C18F10.7; C18F10.7a.1; C18F10.7a.2; 3H366; CE00784; CE30608; WBGene00015978; WP:CE00784; WP:CE30608 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C24G6.3 Aff_C24G6.3 C24G6.3; 5F999; CE29673; WBGene00016060; WP:CE29673 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C25A1.12 Aff_C25A1.12 C25A1.12; 1K768; CE08378; WBGene00007711; WP:CE08378 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C25A1.9 Aff_C25A1.9 C25A1.9; 1K763; CE18532; WBGene00007710; WP:CE18532 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C27B7.5 Aff_C27B7.5 C27B7.5; 4J667; CE03034; WBGene00007762; WP:CE03034 Zinc finger, CCHC class Jiang et al 2001 Fig1 hermaphrodite-enriched TF, Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Romagnolo et al 2002 Fig3b TF, ViswanathanM et al 2005 S2 sir-2.1 regulated C27C7.1 Aff_C27C7.1 C27C7.1; 1M31; CE19705; WBGene00007766; WP:CE19705 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C28A5.1 Aff_C28A5.1 C28A5.1; 3F520; CE00675; WBGene00007788; WP:CE00675 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C32D5.10 Aff_C32D5.10 C32D5.10; 2G640; CE29688; WBGene00016317; WP:CE29688 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C32E8.9 Aff_C32E8.9 C32E8.9; 1E364; CE29693; WBGene00016325; WP:CE29693 Romagnolo et al 2002 Fig3b Metabolism, ViswanathanM et al 2005 S2 sir-2.1 regulated C34B2.2 Aff_C34B2.2 kbp-5; C34B2.2; 1L263; CE16890; NM_060399; WBGene00016387; WP:CE16890 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C35D6.4 Aff_C35D6.4 C35D6.4; 4R103; CE15683; WBGene00007961; WP:CE15683 Zinc finger C-x8-C-x5-C-x3-H type (and similar). (2 domains) Lund et al 2002 Fig3D Oocyte-en, ViswanathanM et al 2005 S2 sir-2.1 regulated C41C4.4 Aff_C41C4.4 ire-1; C41C4.4; 2I404; CE35836; NM_063300; WBGene00002147; WP:CE35836 ire-1 encodes a transmembrane serine/threonine protein kinase and site-specific endoribonuclease orthologous to Saccharomyces cerevisiae inositol-requiring 1 protein kinase (Ire1) and human endoplasmic reticulum-to-nucleus signaling 1 (ERN1, OMIM:604033); IRE-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); in response to ER stress, IRE-1 cleaves xbp-1 mRNA to produce transcriptionally active XBP-1 that positively regulates UPR gene expression in order to maintain ER homeostasis. serine/threonine kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C47B2.6 Aff_C47B2.6 C47B2.6; 1N569; CE17566; CE38295; WBGene00008132; WP:CE17566; WP:CE38295 The C47B2.6 gene encodes an ortholog of the human gene UDP-GALACTOSE-4-EPIMERASE (GALE; OMIM:606953), which when mutated leads to galactose epimerase deficiency (OMIM:230350). NAD dependant epimerase/dehydratase family Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C47C12.4 Aff_C47C12.4 C47C12.4; CE08797; WBGene00016737; WP:CE08797; XI366 ATP/GTP-binding protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C48B4.10 Aff_C48B4.10 C48B4.10; 3K654; CE33604; WBGene00008173; WP:CE33604 Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated F02A9.4 Aff_F02A9.5 F02A9.4; F02A9.5; 3K174; CE00136; CE33612; WBGene00008514; WP:CE00136; WP:CE33612 F02A9.4 is orthologous to the human gene SIMILAR TO METHYLCROTONOYL-COENZYME A CARBOXYLASE 2 (BETA) (MCCC2; OMIM:210210), which when mutated leads to disease. Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F09F7.4 Aff_F09F7.4 F09F7.4; F09F7.4a.1; F09F7.4a.2; F09F7.4b.1; F09F7.4b.2; F09F7.4b.3; 3G645; CE00689; CE30654; WBGene00017301; WP:CE00689; WP:CE30654 Enoyl-CoA hydratase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F13A7.10 Aff_F13A7.10 gst-44; F13A7.10; 5Q869; CE15815; NM_074741; WBGene00001792; WP:CE15815 glutathione S-transferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F13G3.5 Aff_F13G3.5 F13G3.5; F13G3.5.1; F13G3.5.2; 1H878; CE29761; WBGene00008765; WP:CE29761 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. myo-inositol-1-monophosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F14H3.5 Aff_F14H3.5 F14H3.5; 5Q536; CE15830; WBGene00008824; WP:CE15830 Golden et al 2004, daf-2 differentially expressed , Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F14H3.6 Aff_F14H3.6 F14H3.6; 5Q538; CE23652; WBGene00008825; WP:CE23652 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E F26D10.3 Aff_F26D10.3 hsp-1; F26D10.3; F26D10.3.1; F26D10.3.2; F26D10.3.3; T28F3.2; 4S223; CE09682; NM_070667; WBGene00002005; WP:CE09682 hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity. HSP-1 heat shock 70kd protein A Custodia et al 2001 T2 heat shock, Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated F29B9.4 Aff_F29B9.4 psr-1; tag-159; F29B9.4; F29B9.4a.1; F29B9.4a.2; F29B9.4b.1; F29B9.4b.2; 4F419; CE27146; CE39926; NM_068205; WBGene00004205; WP:CE27146; WP:CE39926 psr-1 encodes an ortholog of the mammalian apoptotic phosphatidylserine receptor, whose product recognizes phosphatidylserine on apoptotic cells and enables cells expressing the receptor to recognize and engulf apoptotic cells in a phosphatidylserine-specific manner; psr-1 was not mutated in classical screens for Ced mutants, but, given its high similarity, may nevertheless mediate phosphatidylserine recognition on apoptotic cells during their removal by phagocytes. Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F30A10.5 Aff_F30A10.5 stl-1; F30A10.5; F30A10.5.1; F30A10.5.2; 1K62; CE32397; NM_060116; WBGene00006061; WP:CE32397 erythrocyte band 7 integral membrane protein like Jones et al 2001 Non dauer genes P<0.05, Kwon et al 2004 T1 late-induction Ethanol-response, Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F35D2.3 Aff_F35D2.3 F35D2.3; 2H861; CE31804; WBGene00018041; WP:CE31804 Baugh et al 2005, PAL-1 target genes, Jones et al 2001 Non dauer genes P<0.05 F35G12.6 Aff_F35G12.6 mab-21; F35G12.6; 3F691; CE32651; NM_065539; WBGene00003112; WP:CE32651 mab-21 encodes a novel protein that is a member of a highly conserved family of proteins with Drosophila and vertebrate orthologs; MAB-21 is cell-autonomously required for specifying the identity of sensory ray 6 in the male tail, and also for backward locomotion, normal body morphology, fecundity, and embryonic morphogenesis; MAB-21 expression begins in embryonic hypodermal cells and continues in larval and adult animals in hypodermis, anterior and ventral cord neurons, some body wall muscles, and ray cells. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F36D1.1 Aff_F36D1.1 F36D1.1; 1L870; CE19832; WBGene00009461; WP:CE19832 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F36F12.8 Aff_F36F12.8 F36F12.8; 5C569; CE17788; WBGene00018099; WP:CE17788 zinc finger protein Kwon et al 2004 T1 late-induction Ethanol-response, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F37F2.2 Aff_F37F2.2 F37F2.2; 1B916; CE32185; WBGene00018159; WP:CE32185 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F42A8.2 Aff_F42A8.2 tag-55; F42A8.2; F42A8.2.1; F42A8.2.2; F42A8.2.3; 2J642; CE01579; WBGene00006433; WP:CE01579 tag-55/F42A8.2 is orthologous to the human gene SUCCINATE DEHYDROGENASE COMPLEX, SUBUNIT B, IRON SULFUR PROTEIN (SDHB; OMIM:185470), which when mutated leads to extraadrenal pheochromocytoma; F42A8.2 protein is predicted to be mitochondrial. succinate dehydrogenase (ubiquinone) iron sulphur protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F43D2.1 Aff_F43D2.1 F43D2.1; 5P93; CE38186; WBGene00009650; WP:CE38186 G1/S-specfic cyclin C like Jiang et al 2001 Fig2 cyclin-genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F43E2.8 Aff_F43E2.8 hsp-4; F43E2.8; F43E2.8.1; F43E2.8.2; 2H640; CE07244; NM_063135; WBGene00002008; WP:CE07244 hsp-4 encodes a predicted homolog of the mammalian ER chaperone BiP that affects embryonic and larval viability; expression is most prominent in the spermatheca and transcription of hsp-4 is induced in the gut and in the hypodermis upon ER stress. heat shock protein Kwon et al 2004 T1 late-induction Ethanol-response, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 UPR genes F43G6.9 Aff_F43G6.9 patr-1; F43G6.9; F43G6.9.1; F43G6.9.2; 2M66; CE18675; NM_064113; WBGene00009661; WP:CE18675 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F43G9.2 Aff_F43G9.2 F43G9.2; 1J185; CE10356; WBGene00009665; WP:CE10356 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F44E2.7 Aff_F44E2.7 F44E2.7; F44E2.7b.1; F44E2.7b.2; F44E2.7b.3; F44E2.7b.4; F44E2.7b.5; 3J936; CE24975; CE29802; CE30994; CE30995; WBGene00018420; WP:CE24975; WP:CE29802; WP:CE30994; WP:CE30995 Jiang et al 2001 Fig1 hermaphrodite-enriched TF, Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F45B8.2 Aff_F45B8.2 rgs-10; tag-215; F45B8.2; CE10430; NM_078081; WBGene00004353; WBGene00009719; WP:CE10430; XP581 phosphoprotein RGP4 like Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol F45D3.5 Aff_F45D3.5 sel-1; sup-25; F45D3.5; F45D3.5.1; F45D3.5.2; 5N43; CE16043; NM_073743; WBGene00004759; WP:CE16043 sel-1 encodes two isoforms of a highly conserved transmembrane protein orthologous to human SEL1 (OMIM:602329) and Saccharomyces cerevisiae HRD3, a member of the HMG-CoA Reductase Degradation (HRD) complex that degrades malfolded endoplasmic reticulum (ER)-resident proteins; SEL-1 functions as a negative regulator of the LIN-12/GLP-1 Notch-like signaling pathway in C. elegans where it appears to function cell autonomously to regulate LIN-12 turnover; along with ABU-1, an ER-associated Type I transmembrane protein, SEL-1 may be a component of a cell survival pathway induced when unfolded proteins accumulate in the ER; SEL-1 is expressed throughout larval and adult stages of development, and detected in all tissues except the pharynx; within cells, SEL-1 appears to localize to intracellular vesicles, consistent with its proposed role in protein turnover. Yeast hypothetical gene L8167.5 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 UPR genes F49H12.6 Aff_F49H12.B acl-4; F49H12.6; F49H12.6a.1; F49H12.6a.2; CE23754; CE30138; NM_075978; NM_075979; WBGene00018657; WP:CE23754; WP:CE30138; XC686 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F52C6.11 Aff_F52C6.11 bath-2; F52C6.11; 2C178; CE35974; WBGene00018668; WP:CE35974 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F53A2.8 Aff_F53A2.8 cup-6; mtm-6; F53A2.8; F53A2.8b.1; F53A2.8b.2; 3O443; CE16100; CE32050; CE37116; NM_067352; NM_181951; WBGene00003478; WP:CE16100; WP:CE32050; WP:CE37116 mtm-6 encodes a myotubularin-related protein that regulates phosphoinositide 3-phosphate localization and/or levels in vivo and mutation blocks endocytosis by coelomocytes; the MTM-6A isoform, which rescues the endocytic defect of mtm-6 mutants, is believed to function as part of a complex with MTM-9 and MTM-6A is predominantly localized to the coelomocyte cytoplasm, with some localization to the coelomocyte membrane. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F55H2.2 Aff_F55H2.2 vha-14; F55H2.2; F55H2.2.1; F55H2.2.2; 3K599; CE00209; NM_066693; WBGene00010130; WP:CE00209 Membrane-associated atpase gamma chain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56D2.1 Aff_F56D2.1 F56D2.1; F56D2.1.1; F56D2.1.2; 3G683; CE11226; WBGene00018963; WP:CE11226 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Mitochondrial processing protease enhancing protein ViswanathanM et al 2005 S2 sir-2.1 regulated F56H1.4 Aff_F56H1.4 rpt-5; F56H1.4; F56H1.4.1; F56H1.4.2; 1G318; CE17915; NM_059271; WBGene00004505; WP:CE17915 rpt-5 encodes a triple A ATPase subunit of the 26S proteasome's 19S regulatory particle (RP) base subcomplex; RPT-5 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome. ATPase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F57C9.5 Aff_F57C9.5 htp-3; F57C9.5; 1F397; CE11330; NM_059057; WBGene00002034; WP:CE11330 Reinke et al 2004, intrinsic, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E F58A4.10 Aff_F58A4.10 ubc-7; F58A4.10; F58A4.10.1; F58A4.10.2; 3K720; CE00216; NM_066732; WBGene00006704; WP:CE00216 Ubiquitin conjugating enzyme McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F58A4.8 Aff_F58A4.8 sas-3; tbg-1; F58A4.8; F58A4.8.1; F58A4.8.2; 3K716; CE00224; NM_066730; TUBG; WBGene00006540; WP:CE00224 tbg-1 encodes gamma-tubulin; in C. elegans, tbg-1 activity is essential and is required for normal bipolar spindle assembly and function, as well as the fast phase of female pronuclear migration following fertilization; while tbg-1 is required for proper organization and function of kinetochore and interpolar microtubules, it does not appear to be absolutely required for microtubule nucleation and growth; TBG-1 localizes to centrosomes in both interphase and mitotic cells, exhibiting a dynamic behavior during mitosis that differs between anterior and posterior centrosomes. Gamma-like tubulin McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F58H1.3 Aff_F58H1.3 F58H1.3; 5M415; CE39510; WBGene00010286; WP:CE39510 E-1 enzyme McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol H04M03.3 Aff_H04M03.E H04M03.3; H04M03.E; 4G657; CE20922; WBGene00019153; WP:CE20922 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol H12I13.4 Aff_H12I13.A fbf-1; H12I13.4; H12I13.A; 2G370; CE20960; NM_062815; WBGene00001401; WP:CE20960 fbf-1 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-1 is nearly identical to FBF-2 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages. RNA-binding protein H26D21.1 Aff_H26D21.B dam-1; hus-1; H26D21.1; H26D21.B; 1E267; CE20999; NM_058802; WBGene00002042; WP:CE20999 hus-1 encodes the C. elegans ortholog of the Schizosaccharomyces pombe Hus1 DNA damage checkpoint protein; in C. elegans, hus-1 activity is required for DNA damage-induced cell cycle arrest and apoptosis, telomere maintenance, and hence, genome stability and development; specifically, hus-1 is required for the CEP-1/p53-dependent increase in germline egl-1 expression following irradiation; a HUS-1::GFP fusion protein is detected in the nuclei of mitotic and meiotic germ cells, mature oocytes, embryos, and somatic larval cells, particularly those that are proliferating; while HUS-1 localization is generally diffuse throughout these nuclei, following irradiation, HUS-1 localizes to discrete foci that overlap with chromatin; HUS-1 nuclear localization is dependent upon the Rad9 homologue HPR-9 and upon the checkpoint protein MRT-2, with which it interacts in yeast two-hybrid and in vitro assays. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated H38K22.3 Aff_H38K22.3 tag-131; H38K22.3; 3F409; CE18831; WBGene00006478; WP:CE18831 Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit K01A6.2 Aff_K01A6.1 magi-1; K01A6.2; 4M493; CE37387; WBGene00010444; WP:CE37387 membrane-associated guanylate kinase homolog (MAGUK) Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 daf-16 Resveratrol K02B12.7 Aff_K02B12.7 K02B12.7; 1J104; CE11618; WBGene00010500; WP:CE11618 ADP-ribosylation factor 1-directed GTPase activating protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K02F3.10 Aff_K02F3.10 K02F3.10; 3B468; CE01346; WBGene00019333; WP:CE01346 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K05C4.2 Aff_Y105E8A.KK K05C4.2; K05C4.2.1; K05C4.2.2; 1P312; CE19970; WBGene00010579; WP:CE19970 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K07E8.7 Aff_K07E8.7 K07E8.7; 2A932; CE11898; WBGene00019498; WP:CE11898 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA K08D10.4 Aff_K08D10.4 rnp-2; K08D10.4; 4E937; CE28597; NM_068103; WBGene00004385; WP:CE28597 U1 small nuclear ribonucleoprotein A Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K08H10.1 Aff_K08H10.1 lea-1; K08H10.1; K08H10.1.1; K08H10.1.2; 5K507; CE18875; NM_073174; WBGene00002263; WP:CE18875; lea The lea-1 gene encodes a protein that is predicted to be hydrophilic and heat-resistant, and that might participate in anhydrobiosis. ViswanathanM et al 2005 S2 sir-2.1 regulated K08H10.7 Aff_K08H10.7 rde-1; K08H10.7; 5K468; CE28243; NM_171525; WBGene00004323; WP:CE28243 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K11D12.2 Aff_K11D12.2 pqn-51; K11D12.2; K11D12.2.1; K11D12.2.2; K11D12.2.3; K11D12.2.4; 5F529; CE12128; NM_071954; WBGene00004136; WP:CE12128 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K12H4.4 Aff_K12H4.4 phi-20; K12H4.4; K12H4.4.1; K12H4.4.2; 3J133; CE00269; WBGene00019679; WP:CE00269 Signal peptidase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b secretion, ViswanathanM et al 2005 S2 sir-2.1 regulated M142.8 Aff_M142.5 M142.8; 3M25; CE37540; WBGene00043057; WP:CE37540 M7.1 Aff_M7.1 let-70; ubc-2; M7.1; 4L846; CE03482; NM_069664; WBGene00002344; WP:CE03482 let-70 encodes a class I E2 ubiquitin conjugating enzyme; let-70 was identified in screens for essential genes and phenotypic analyses indicate that loss of let-70 activity results in embryonic and larval lethality with defects in sarcomere assembly; purified LET-70 can stimulate the self-ubiquitylation activities of CHN-1 and UFD-2, E4 ubiquitin conjugation factors and, in addition, can stimulate the CHN-1- and UFD-2-dependent multiubiquitylation of UNC-45, a myosin-directed chaperone; in this manner, LET-70 may regulate UNC-45 degradation and myosin assembly; RNA blot analyses and a let-70-lacZ reporter fusion reveal that let-70 is abundantly expressed at all stages of development, including the dauer larval stage; strong staining is observed in most somatic tissues until adult stages, when expression generally becomes restricted to the nervous system. ubiquitin-conjugating enzyme E2-17 KD McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Roy et al 2002 S3 muscle genes, ViswanathanM et al 2005 S2 sir-2.1 regulated M70.4 Aff_M70.4 M70.4; 4D18; CE37266; WBGene00019786; WP:CE37266 M70.4 is orthologous to human O-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE (FLJ20277; OMIM:606822), which when mutated leads to muscle-eye-brain disease. R03A10.4 Aff_R03A10.4 R03A10.4; R03A10.4a.1; R03A10.4a.2; R03A10.4b.1; R03A10.4b.2; CE29335; CE37983; WBGene00010984; WP:CE29335; WP:CE37983; XQ61 gluamine-phenylpyruvate transaminase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated R07H5.2 Aff_R07H5.2 cpt-2; R07H5.2; R07H5.2.1; R07H5.2.2; 4L947; CE18907; WBGene00011122; WP:CE18907 R07H5.2 is orthologous to the human gene CARNITINE PALMITOYLTRANSFERASE II (CPT2; OMIM:600650), which when mutated leads to disease. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R11E3.7 Aff_R11E3.7 dpf-7; R11E3.7; 4F564; CE19549; CE31721; NM_171328; NM_171329; WBGene00001060; WP:CE19549; WP:CE31721 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated R151.6 Aff_R151.6 R151.6; R151.6.1; R151.6.2; 3I312; CE39620; WBGene00020109; WP:CE39620 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA R151.8 Aff_R151.8 R151.8; 3I318; CE27201; WBGene00020111; WP:CE27201 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated R166.2 Aff_R166.2 R166.2; R166.2.1; R166.2.2; 2K826; CE03581; WBGene00011302; WP:CE03581 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T01B7.3 Aff_T01B7.3 rab-21; T01B7.3; 2J2; CE03587; NM_063453; WBGene00004279; WP:CE03587 ras-related protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T04A8.16 Aff_T04A8.16 clp-2; T04A8.16; 3F790; CE01070; NM_065563; WBGene00000543; WP:CE01070 clp-2 encodes a large calpain subunit that contains two predicted MIT (microtubule interacting and trafficking) domains and is homologous to the mammalian Calpain 7 proteins and the atypical, nuclear-localized Aspergillus calpain, PalB; by homology, CLP-2 is predicted to function as a calcium-dependent, cysteine protease that is involved in intracellular proteolysis and peptidolysis; however, as loss of clp-2 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of CLP-2 in C. elegans development and/or behavior is not yet known. Calpain thiol protease T05B9.1 Aff_T05B9.1 T05B9.1; 2L548; CE02310; WBGene00011464; WP:CE02310 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T05E7.3 Aff_T05E7.3 T05E7.3; 1G767; CE13235; WBGene00020259; WP:CE13235 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T05H10.6 Aff_T05H10.6 T05H10.6; T05H10.6a.1; T05H10.6a.2; T05H10.6a.3; T05H10.6a.4; T05H10.6b.1; T05H10.6b.2; CE01643; CE32929; NM_063292; NM_182153; WBGene00011510; WP:CE01643; WP:CE32929 T05H10.6 encodes an ortholog of the human gene PYRUVATE DEHYDROGENASE (LIPOAMIDE) ALPHA 1 (PDHA1; OMIM:312170), which when mutated leads to Leigh syndrome (OMIM:256000); the T05H10.6 protein is predicted to be mitochondrial with 68% accuracy. Golden et al 2004, N2 vs daf-2 different genes at , McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T05H4.13 Aff_T05H4.13 alh-4; T05H4.13; T05H4.13c.1; T05H4.13c.2; 5G908; CE27441; CE30827; CE33307; NM_072233; NM_171471; NM_171472; WBGene00000110; WP:CE27441; WP:CE30827; WP:CE33307 aldehyde dehydrogenase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T05H4.14 Aff_T05H4.14 gad-1; tag-86; T05H4.14; 5G912; CE13295; NM_072234; WBGene00001513; WP:CE13295 The gad-1 gene encodes a WD repeat-containing protein that is required maternally for gastrulation initiation during early embryogenesis by regulating the division timing, spindle orientation, and subsequent inward migration of the two gut precusor (E) cells at the 26-cell stage. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T06D8.8 Aff_T06D8.8 rpn-9; T06D8.8; T06D8.8.1; T06D8.8.2; 2L528; CE02329; NM_064004; WBGene00004465; WP:CE02329 rpn-9 is predicted to encode a non-ATPase subunit of the 19S regulatory complex of the proteasome that that affects body morphology, embryonic viability, locomotion, larval viability, fertility, and growth; interacts with RPN-11 in yeast two-hybrid assays. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T08D2.6 Aff_T08D2.F T08D2.6; CE21172; WBGene00011611; WP:CE21172; XA805 T09B4.1 Aff_T09B4.1 T09B4.1; 1G763; CE13457; WBGene00020375; WP:CE13457 Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T10F2.2 Aff_T10F2.2 T10F2.2; 3G254; CE02041; WBGene00020422; WP:CE02041 T10F2.2 is orthologous to the human gene SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER; ORNITHINE TRANSPORTER) MEMBER 15 (SLC25A15; OMIM:603861), which when mutated leads to disease. Mitochondrial carrier protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T15B7.2 Aff_T15B7.2 T15B7.2; T15B7.2.1; T15B7.2.2; 5H319; CE33319; WBGene00020517; WP:CE33319 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, herm soma enriched genes, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T16G1.11 Aff_T16G1.11 eif-3.K; pqn-69; T16G1.11; 5N435; CE20081; NM_073840; WBGene00001233; WP:CE20081 The protein product of this gene was predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS72 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T20F5.6 Aff_T20F5.6 T20F5.6; T20F5.6.1; T20F5.6.2; 1E490; CE28685; WBGene00020628; WP:CE28685 zinc finger protein Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T21C9.12 Aff_T21C9.12 T21C9.12; 5L81; CE06481; WBGene00011897; WP:CE06481 REV protein (anti-repression transactivator protein) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T22D1.3 Aff_T22D1.3 T22D1.3; T22D1.3b.1; T22D1.3b.2; 4H681; CE30188; CE33940; WBGene00020682; WP:CE30188; WP:CE33940 inosine monophosphate dehydrogenase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T22F3.2 Aff_T22F3.2 T22F3.2; 5E67; CE13964; CE30837; WBGene00020695; WP:CE13964; WP:CE30837 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T23B12.4 Aff_T23B12.4 T23B12.4; 5I945; CE29351; WBGene00020719; WP:CE29351 Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T23D8.4 Aff_T23D8.4 eif-3.C; T23D8.4; T23D8.4.1; T23D8.4.2; 1K554; CE18958; NM_060237; WBGene00001226; WP:CE18958 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T26A5.3 Aff_T26A5.3 tag-99; T26A5.3; 3H557; CE00702; WBGene00006463; WP:CE00702 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. NADH-ubiquinone oxidoreductase ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T28A8.4 Aff_T28A8.4 T28A8.4; 3O593; CE18975; WBGene00012110; WP:CE18975 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T28F3.1 Aff_F26D10.4 T28F3.1; 4S226; CE09683; CE19806; WBGene00012128; WP:CE09683; WP:CE19806 C2 domain Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Shen et al 2005 T1 hif-1 depend hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated VF11C1L.1 Aff_VF11C1L.1 ppk-3; C05E7.5; VF11C1L.1; CE18979; NM_077754; WBGene00004089; WP:CE18979; XN588 FYVE zinc finger McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol VW02B12L.3 Aff_VW02B12L.3 ebp-2; VW02B12L.3; VW02B12L.3.1; VW02B12L.3.2; 2L733; CE18982; WBGene00012156; WP:CE18982 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order W02A11.3 Aff_W02A11.3 W02A11.3; W02A11.3.1; W02A11.3.2; 1N331; CE18990; WBGene00012194; WP:CE18990 Zinc finger, C3HC4 type (RING finger) ViswanathanM et al 2005 S2 sir-2.1 regulated W02B12.10 Aff_W02B12.10 W02B12.10; 2L762; CE03770; WBGene00012205; WP:CE03770 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated W04B5.5 Aff_W04B5.5 W04B5.5; 3D502; CE20142; PIAK; WBGene00021022; WP:CE20142 The W04B5.5 gene encodes a phospholipid-independent AKT/PKB kinase. protein kinase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated W09B6.4 Aff_W09B6.4 W09B6.4; 2B424; CE39038; CE39801; WBGene00021104; WP:CE39038; WP:CE39801 ViswanathanM et al 2005 S2 sir-2.1 regulated Y113G7A.9 Aff_Y113G7A.K dcs-1; hsl-1; Y113G7A.9; 5U558; CE23280; DcpS; NM_075475; WBGene00000940; WP:CE23280 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y14H12B.2 Aff_Y14H12B_90.A Y14H12B.2; 2E222; CE21366; WBGene00021192; WP:CE21366 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y18H1A.4 Aff_Y18H1A_68.E Y18H1A.4; 1B166; CE29367; WBGene00021210; WP:CE29367 Y19D10A.16 Aff_C01B4.H Y19D10A.16; WBGene00044734 Y23H5A.2 Aff_Y23H5A.2 Y23H5A.2; 1D191; CE18358; WBGene00021269; WP:CE18358 Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y23H5A.3 Aff_Y23H5A.3 Y23H5A.3; 1D189; CE18359; WBGene00021270; WP:CE18359 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y32B12B.4 Aff_Y32B12B.4 Y32B12B.4; 5R43; CE24197; WBGene00012524; WP:CE24197 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen Y37D8A.2 Aff_Y37D8A.2 Y37D8A.2; Y37D8A.2.1; Y37D8A.2.2; 3N913; CE20207; WBGene00012544; WP:CE20207 ViswanathanM et al 2005 S2 sir-2.1 regulated Y38F1A.2 Aff_Y38F1A.B Y38F1A.2; Y38F1A.B; 2N247; CE21607; WBGene00012606; WP:CE21607 Zinc finger, C3HC4 type (RING finger) ViswanathanM et al 2005 S2 sir-2.1 regulated Y39E4A.3 Aff_Y39E4A.3 Y39E4A.3; Y39E4A.3a.1; Y39E4A.3a.2; Y39E4A.3a.3; 3O58; CE33866; CE38987; WBGene00012713; WP:CE33866; WP:CE38987 Y39E4A.3 is orthologous to the human gene MAPLE SYRUP URINE DISEASE, TYPE IA (MSUD, TYPE IA; E1-alpha subunit of branched-chain keto acid dehydrogenase; OMIM:248600), which when mutated leads to maple syrup urine disease; Y39E4A.3 protein is predicted to be mitochondrial. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y39H10A.7 Aff_Y39H10A_224.A chk-1; Y39H10A.7; Y39H10A.7b.1; Y39H10A.7b.2; Y39H10A_224.A; 5E232; CE26076; CE33867; WBGene00000498; WP:CE26076; WP:CE33867 chk-1 encodes a CHK1-like serine threonin protein kinase that affects fertility. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, male germline, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination Y41C4A.9 Aff_Y41C4A.9 Y41C4A.9; Y41C4A.9.1; Y41C4A.9.2; Y41C4A.9.3; 3M800; CE20249; WBGene00012756; WP:CE20249 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y43C5A.5 Aff_Y43C5A.5 thk-1; Y43C5A.5; 4L44; CE19154; NM_069485; WBGene00006568; WP:CE19154 thymidine kinases Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated Y43C5A.6 Aff_Y43C5A.6 rad-51; rdh-1; Y43C5A.6; 4L46; CE25285; CE29064; NM_069486; WBGene00004297; WP:CE25285; WP:CE29064; rad51 rad-51 encodes two isoforms of a protein orthologous to S. cerevisiae Rad51p and Dmc1p, and to E. coli RecA, and paralogous to C30A5.2; RAD-51 proteins are probably required for meiotic recombination; while dispensable for viability and meiotic synapsis, RAD-51A/B are required for normal chromosomal morphology, univalent formation, dissociation of chiasmata, hyperresistance of meiotic pachytene nuclei to X-irradiation, and the progress of oocytes through diakinesis; RAD-51A/B require CHK-2, MRE-11, and SPO-11 to localize to foci in late zygotene/early pachytene nuclei, and genetically acts downstream of CHK-2 and SPO-11; RAD-51A/B foci later disappear from homologously synapsed chromosomes. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y45F3A.9 Aff_Y45F3A.9 Y45F3A.9; CE19170; WBGene00012864; WP:CE19170 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. SpoU rRNA Methylase family McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated Y47D3A.4 Aff_Y47D3A.G cku-70; Y47D3A.4; 3M257; CE28984; NM_067037; WBGene00000519; WP:CE28984 ViswanathanM et al 2005 S2 sir-2.1 regulated Y48A5A.1 Aff_Y48A5A.C Y48A5A.1; 4C733; CE37290; WBGene00021655; WP:CE37290 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y48B6A.12 Aff_Y119D3_452.A Y48B6A.12; Y48B6A.12.1; Y48B6A.12.2; Y48B6A.12.3; 2O518; CE22127; WBGene00012983; WP:CE22127 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y48C3A.18 Aff_Y48C3A.T Y48C3A.18; 2N703; CE22152; WBGene00012997; WP:CE22152 Y49E10.1 Aff_Y49E10.C rpt-6; Y49E10.1; Y49E10.B; Y49E10.C; 3N461; CE22219; NM_067208; WBGene00004506; WP:CE22219 rpt-6 encodes a triple A ATPase that is a subunit of the 26S proteasome 19S regulatory particle (RP) base subcomplex; RPT-6 is required for embryonic and larval development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome. ATPases associated with various cellular activities (AAA) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated Y53G8AL.2 Aff_Y53G8A_9248.D Y53G8AL.2; Y53G8AL.2.1; Y53G8AL.2.2; 3E332; CE26163; WBGene00021800; WP:CE26163 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y54G2A.4 Aff_Y94H6A_148.V Y54G2A.4; Y94H6A_148.I; 4D701; CE31654; WBGene00021870; WP:CE31654 Y55F3AM.13 Aff_Y55F3A_748.B Y55F3AM.13; 4B808; CE22542; WBGene00021930; WP:CE22542 Murphy et al 2003 Fig2 Class2 shorten lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y56A3A.17 Aff_Y56A3A.P npp-16; Y56A3A.17; 3N7; CE22584; CE22585; CeNup50; NM_067149; NM_067150; WBGene00003802; WP:CE22584; WP:CE22585 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57E12AL.5 Aff_Y57E12_247.D let-425; mdt-6; med-6; Y57E12AL.5; Y57E12_247.D; 5H538; CE25510; NM_072390; WBGene00003164; WP:CE25510 mdt-6 encodes a highly conserved transcriptional mediator of the Med6 family that includes Saccharomyces cerevisiae Med6 and human MED6 (OMIM:602984); MDT-6 is an essential gene required maternally for embryogenesis and zygotically for postembryonic transcriptional regulation of genes involved in the Ras and Wnt signaling pathways that mediate vulval and male tail formation, respectively; mdt-6 is expressed in all cells at all stages and localizes to the peripheral region of nuclei, where actively transcribed portions of the genome may be localized. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y57G11C.12 Aff_Y57G11C.12 nuo-3; Y57G11C.12; Y57G11C.12.1; Y57G11C.12.2; Y57G11C.12.3; Y57G11C.12.4; 4P560; CE14948; WBGene00013308; WP:CE14948 NADH-ubiquinone oxidoreductase Golden et al 2004, N2 vs daf-2 different genes at , McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y73F8A.34 Aff_Y73F8A.NN tag-349; Y73F8A.34; Y73F8A.34a.1; Y73F8A.34a.2; Y73F8A.34b.1; Y73F8A.34b.2; 4Q290; CE25598; CE39877; WBGene00013538; WP:CE25598; WP:CE39877 Y75B8A.14 Aff_Y75B8A.R Y75B8A.14; 3N306; CE23026; WBGene00013550; WP:CE23026 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes Y77E11A.11 Aff_Y77E11A_3443.L clp-7; Y77E11A.11; Y77E11A.11.1; Y77E11A.11.2; 4C200; CE25612; NM_067681; WBGene00000547; WP:CE25612 clp-7 encodes a member of the calpain family of cysteine proteases. ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZC53.7 Aff_ZC53.7 rgs-9; ZC53.7; CE07589; NM_075949; WBGene00004352; WBGene00022513; WP:CE07589; XC535 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1248.13 Aff_ZK1248.12 ZK1248.13; 2G120; CE33497; WBGene00022882; WP:CE33497 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1320.6 Aff_ZK1320.6 arc-1; arl-4; ZK1320.6; 2J967; CE37598; NM_063688; WBGene00000180; WP:CE37598 arc-1 encodes a member of the ARL (ADP-ribosylation factor(ARF)-like) family of proteins which are very similar to ARF proteins but lack the ability to stimulate ADP ribosylation by cholera toxin; arc-1 has a human homolog, MID1, which when mutated leads to Opitz syndrome (OMIM:300000). ADP-ribosylation factors (Arf family) (contains ATP/GTP binding P-loop), Zinc finger, C3HC4 type (RING finger) ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK353.8 Aff_ZK353.8 ubxn-4; ZK353.8; ZK353.8.1; ZK353.8.2; 3J494; CE00392; WBGene00022703; WP:CE00392 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK512.5 Aff_ZK512.5 ZK512.5; ZK512.5.1; ZK512.5.2; 3K219; CE00411; WBGene00013985; WP:CE00411 ZK675.1 Aff_ZK675.1 ptc-1; ZK675.1; ZK675.1.1; ZK675.1.2; 2I189; CE01720; NM_063261; WBGene00004208; WP:CE01720 ptc-1 is orthologous to Drosophila patched and human PTC; mutation of human PTC leads to nevoid basal cell carcinoma syndrome (OMIM:109400). membrane protein patched McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK809.4 Aff_ZK809.4 ent-1; ZK809.4; 4M418; CE31754; NM_069803; WBGene00001320; WP:CE31754 ent-1 encodes a predicted equilibrative nucleoside transporter 1 that affects growth. hydrophobic nucleolar protein like Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK829.9 Aff_ZK829.9 ZK829.9; 4M735; CE06657; WBGene00014097; WP:CE06657 glucose transporter ViswanathanM et al 2005 S2 sir-2.1 regulated ZK970.3 Aff_ZK970.3 mdt-22; ZK970.3; 2K591; CE02403; NM_063815; WBGene00007022; WP:CE02403 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes