Baugh et al 2003, subclass E_66min, 275 genes Gene list file name: Baugh2003_classEpi_66min.txt Type of gene identifier: Affymetrix custom chip Description: Baugh et al 2005, Supplymental Dataset, subclass E_66min Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations AFF_B0564.10 Aff_B0564.10 AFF_C49A1.8 Aff_C49A1.8 AFF_F22D6.13 Aff_F22D6.13 AFF_F32A5.7 Aff_F32A5.7 AFF_F39E9.3 Aff_F39E9.3 AFF_H24O09.C Aff_H24O09.C AFF_R11G1.2 Aff_R11G1.2 AFF_T13C5.6 Aff_T13C5.6 AFF_T23H2.6 Aff_T23H2.6 AFF_Y41D4A_2491.A Aff_Y41D4A_2491.A AFF_Y71F9A_294.B Aff_Y71F9A_294.B AFF_ZK688.7 Aff_ZK688.7 B0024.14 Aff_B0024.14 crm-1; B0024.14; B0024.14c.1; B0024.14c.2; 5K804; CE31276; CE31277; CE31278; CE31279; CE36907; NM_171529; NM_171530; NM_171531; NM_171935; WBGene00007103; WP:CE31276; WP:CE31277; WP:CE31278; WP:CE31279; WP:CE36907 pro-collagen domains ViswanathanM et al 2005 S2 daf-16 Resveratrol B0218.1 Aff_B0218.1 B0218.1; B0218.1a.1; B0218.1a.2; B0218.1a.3; B0218.1a.4; B0218.1a.5; B0218.1b.1; B0218.1b.2; B0218.1b.3; 4I925; CE06684; CE33351; WBGene00015047; WP:CE06684; WP:CE33351 amidase McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0238.11 Aff_B0238.11 B0238.11; B0238.11.1; B0238.11.2; 5F747; CE07701; WBGene00015075; WP:CE07701 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0252.3 Aff_B0252.3 B0252.3; B0252.3c.1; B0252.3c.2; 2H194; CE30586; CE32095; CE34631; WBGene00015088; WP:CE30586; WP:CE32095; WP:CE34631 ViswanathanM et al 2005 S2 sir-2.1 regulated B0304.1 Aff_B0304.1 hlh-1; B0304.1; 2E811; CE02423; CE30067; CE31766; MyoD1; WBGene00001948; WP:CE02423; WP:CE30067; WP:CE31766 hlh-1 encodes a basic helix-loop-helix (bHLH) transcription factor that is the sole C. elegans member of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryonic development for the proper differentiation and function of body wall muscle cells, indicating that unlike its vertebrate counterparts, hlh-1 is not absolutely required for body wall muscle specification; however, ectopic expression of hlh-1 in the embryo is sufficient to convert nearly all embryonic cell types to a muscle-like fate; in regulating body wall muscle cell development in some cell lineages, hlh-1 likely lies downstream of the PAL-1 homeodomain protein that is required for specification of the C and D founder cell fates; HLH-1 is expressed in nuclei and first appears in body wall muscle precursors beginning at the ~80-cell stage of embryogenesis; expression then continues in these cells and their differentiated descendants throughout embryonic, larval, and adult stages of development. helix-loop-helix transcription factor Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Roy et al 2002 S2 positivecontrol L1 muscle, ViswanathanM et al 2005 S2 sir-2.1 regulated B0336.1 Aff_B0336.1 wrm-1; B0336.1; B0336.1.1; B0336.1.2; 3G815; CE26743; NM_065835; WBGene00006943; WP:CE26743 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0336.10 Aff_B0336.10 rpl-23; B0336.10; B0336.10.1; B0336.10.2; 3G794; CE00778; NM_065830; WBGene00004435; WP:CE00778 rpl-23 encodes a large ribosomal subunit L23 protein. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0412.4 Aff_B0412.4 rps-29; B0412.4; B0412.4.1; B0412.4.2; 3B413; CE26849; NM_064862; WBGene00004498; WP:CE26849 rps-29 encodes a small ribosomal subunit S29 protein; by homology, RPS-29 is predicted to function in protein biosynthesis; in C. elegans, RPS-29 activity is broadly required for embryonic and germline development, normal body coloration and morphology, normal postembryonic growth rates, and the overall health of the animal. 40S ribosomal protein S29 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C01F1.1 Aff_C01F1.1 C01F1.1; 2E595; CE06742; WBGene00015296; WP:CE06742 dna binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C01G10.8 Aff_C01G10.8 C01G10.8; C01G10.8.1; C01G10.8.2; 5P564; CE07817; WBGene00007235; WP:CE07817 Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C01G6.2 Aff_C01G6.2 C01G6.2; 2J557; CE02958; WBGene00007224; WP:CE02958 Reinke et al 2004, herm sperm, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, IVb male soma enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster D, ViswanathanM et al 2005 S2 sir-2.1 regulated C03A7.4 Aff_C03A7.4 pqn-5; C03A7.4; 5F633; CE07862; NM_071981; WBGene00004099; WP:CE07862 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 T1 pqn genes C03B1.7 Aff_C03B1.7 C03B1.7; CE03909; WBGene00015378; WP:CE03909; XG963 C03D6.8 Aff_C03D6.8 rpl-24.2; C03D6.8; C03D6.8.1; C03D6.8.2; 1K245; CE05202; NM_060171; WBGene00004437; WP:CE05202 rpl-24.2 encodes a large ribosomal subunit L24 protein paralog; its orthologs include ribosomal protein L30 isologs from mammals and 'Ribosomal Like Protein 24' (Rlp24p) from S. cerevisiae; it therefore appears to actually represent an ancient paralogy between two varieties of eukaryotic L24 protein. ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C05C8.2 Aff_C05C8.2 C05C8.2; 5H713; CE07920; WBGene00015461; WP:CE07920 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C05E4.9 Aff_H24O09.A gei-7; C05E4.9; C05E4.9a.1; C05E4.9a.2; C05E4.9a.3; C05E4.9b.1; C05E4.9b.2; 5B204; CE23521; CE32565; NM_070905; WBGene00001564; WP:CE23521; WP:CE32565 gei-7 encodes a predicted isocitrate lyase/malate synthase, an enzyme known to function in the glyoxylate cycle; GEI-7 was identified in a screen for proteins that interact with GEX-3, a homolog of human HEM-2 which is required for embryonic development; GEI-7 is required for embryonic morphogenesis and appears to act downstream of DAF-16 to influence lifespan. McCarroll et al 2004 SFig5 conserved w/ yeast, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated C06E2.5 Aff_C06E2.5 C06E2.5; C06E2.5.1; C06E2.5.2; CE30595; WBGene00015529; WP:CE30595; XJ476 C07A12.7 Aff_C07A12.7 C07A12.7; C07A12.7a.1; C07A12.7a.2; C07A12.7c.1; C07A12.7c.2; CE25764; CE27055; CE33557; WBGene00015561; WP:CE25764; WP:CE27055; WP:CE33557; XF138 C07B5.5 Aff_C07B5.5 nuc-1; C07B5.5; CE00895; NM_077203; WBGene00003828; WP:CE00895; XK159 The nuc-1 gene encodes a DNase II homolog similar to mammalian and Drosophila DNaseII enzymes and is required for DNA degradation during apoptosis as well as for degradation of dietary DNA during normal feeding; during apoptosis, NUC-1 functions in apoptotic cells at an intermediate stage of DNA degradation, after the killing step, but prior to cell-corpse engulfment. Golden et al 2004, daf-2 differentially expressed , McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C08B11.9 Aff_C08B11.9 C08B11.9; CE01479; WBGene00007436; WP:CE01479 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C10C5.3 Aff_C10C5.3 C10C5.3; 4K139; CE03011; WBGene00007507; WP:CE03011 aminoacylase-1 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated C10C5.5 Aff_C10C5.5 C10C5.5; 4K147; CE36099; WBGene00007509; WP:CE36099 aminoacylase-1 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C11H1.4 Aff_C11H1.6 prx-1; C11H1.4; CE30339; NM_077985; WBGene00004191; WP:CE30339; XO943; pex1 prx-1 encodes a predicted peroxin, a subfamily 2 member of the AAA (ATPases Associated with diverse cellular Activities) family that affects growth in one large-scale RNAi screen; expressed in intestinal cells throughout development. peroxisome biosynthesis protein like ViswanathanM et al 2005 S2 sir-2.1 regulated C13F10.7 Aff_C13F10.7 C13F10.7; 5H702; CE08148; WBGene00015746; WP:CE08148 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C14A4.4 Aff_C14A4.4 crn-3; C14A4.4; 2K881; CE02145; CE32797; NM_063882; NM_182164; WBGene00000796; WP:CE02145; WP:CE32797 crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C14B9.2 Aff_C14B9.2 C14B9.2; C14B9.2.1; C14B9.2.2; 3J225; CE30601; WBGene00015752; WP:CE30601 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. erp72 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C14H10.2 Aff_C14H10.2 C14H10.2; CE23543; WBGene00007592; WP:CE23543; XK862 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C16A3.6 Aff_C16A3.6 C16A3.6; 3H469; CE04006; WBGene00015811; WP:CE04006 Lund et al 2002 Fig1 aging-regulated genes, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C16C10.6 Aff_C16C10.6 C16C10.6; 3F258; CE01497; WBGene00007627; WP:CE01497 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated C17G1.7 Aff_C17G1.7 C17G1.7; C17G1.7.1; C17G1.7.2; CE39223; WBGene00007653; WP:CE39223; XK572 cysteine synthase Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order C23H4.6 Aff_C23H4.6 C23H4.6; CE08332; WBGene00007694; WP:CE08332; XM859 Yeast RAD18 protein like Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 daf-16 Resveratrol C26D10.2 Aff_C26D10.2 hel-1; C26D10.2; C26D10.2b.1; C26D10.2b.2; 2I618; CE03025; CE32593; WBGene00001840; WP:CE03025; WP:CE32593; hel translation initiation factor eIF-4A McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C26F1.4 Aff_C26F1.4 rps-30; C26F1.4; C26F1.4.1; C26F1.4.2; C26F1.4.3; 5I257; CE06878; NM_072606; WBGene00004499; WP:CE06878 rps-30 encodes two proteins, a small ribosomal subunit S30 protein and ubiquitin, which is cleaved from the ribosomal protein posttranslationally; by homology, S30 is predicted to function in protein biosynthesis and ubiquitin in protein degradation; in C. elegans, loss of rps-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. ribosomal protein/ubiquitin-like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C27D8.3 Aff_C27D8.3 C27D8.3; 4N472; CE08422; CE39679; WBGene00007779; WP:CE08422; WP:CE39679 The C27D8.3 gene encodes a protein that may be involved in apoptosis. ViswanathanM et al 2005 S2 sir-2.1 regulated C28H8.1 Aff_C28H8.1 C28H8.1; 3H17; CE01820; WBGene00016192; WP:CE01820 C28H8.1 is orthologous to the human gene BCL7A (OMIM:601406), which when mutated leads to high-grade B-cell non-Hodgkin lymphoma. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, IVb male soma enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C29F3.1 Aff_C29F3.1 ech-1; C29F3.1; 5P838; CE08435; NM_074409; WBGene00001150; WP:CE08435 long-chain enoyl-CoA hydratase C31H2.4 Aff_C31H2.4 C31H2.4; CE04132; WBGene00016294; WP:CE04132; XF772 C31H2.4 is orthologous to human 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (HPD; OMIM:276710), which when mutated leads to tyrosinemia type III; C31H2.4 is somewhat less similar to human HPD than C. elegans HPD-1 (to which C31H2.4 is paralogous). Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated C31H5.4 Aff_C31H5.4 C31H5.4; C31H5.4.1; C31H5.4.2; 1J618; CE17484; NM_060029; WBGene00007855; WP:CE17484 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C33H5.12 Aff_C33H5.12 rsp-6; srp-1; C33H5.12; C33H5.12a.1; C33H5.12a.2; C33H5.12b.1; C33H5.12b.2; 4I554; CE04155; CE29697; CE29698; CeSRp20; NM_171383; NM_171384; NM_171385; WBGene00004703; WP:CE04155; WP:CE29697; WP:CE29698 RNA binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C34G6.4 Aff_C34G6.4 pgp-2; C34G6.4; 1G471; CE29212; NM_059306; WBGene00003996; WP:CE29212 pgp-2 encodes a member of the ABC transporter family with highest similarity to the vertebrate MDR (multidrug resistance) family, and is orthologous to human MDR1 (ABCB1; OMIM:171050, mutated in Crohn disease); PGP-2 is expressed at lower levels during the embryonic stages with higher expression later in development. abc transporter McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C C36B7.6 Aff_C36B7.6 C36B7.6; C36B7.6.1; C36B7.6.2; CE34267; WBGene00016469; WP:CE34267; XH716 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C36E8.5 Aff_C36E8.5 rot-2; tbb-2; C36E8.5; C36E8.5.1; C36E8.5.2; C36E8.5.3; 3F106; CE00913; NM_065405; TUBB8; WBGene00006537; WP:CE00913 tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis. beta tubulin ViswanathanM et al 2005 S2 sir-2.1 regulated C37A2.7 Aff_C37A2.7 C37A2.7; C37A2.7.1; C37A2.7.2; 1H366; CE30433; WBGene00016493; WP:CE30433 ribosomal protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated C37C3.2 Aff_C37C3.2 phi-18; C37C3.2; C37C3.2a.1; C37C3.2a.2; C37C3.2b.1; C37C3.2b.2; C37C3.2b.3; C37C3.2b.4; C37C3.2c.1; C37C3.2c.2; 5I337; CE27367; CE29707; CE32821; WBGene00016496; WP:CE27367; WP:CE29707; WP:CE32821 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C37E2.5 Aff_C37E2.5 ceh-37; C37E2.5; CE08624; NM_077965; WBGene00000458; WP:CE08624; XO816 ceh-37 encodes one of three C. elegans proteins with an OTX-like homeodomain; however, CEH-37 lacks other domains found in OTX proteins, and the CEH-37 homeodomain is predicted to resemble the Myb domain of telomere-binding proteins; CEH-37 binds the telomeric sequence 'TTAGGC' if it is repeated at least 1.5 times, and is mainly localized to the telomere in vivo; ceh-37 mutants have a weak increase in chromosomal nondisjunction; CEH-37 is involved in specifying some aspects of the AWB olfactory neuron fate, such as expression of an AWB-specific odorant receptor and a LIM-class homeodomain protein, LIM-4; CEH-37 is expressed broadly in the early embryo, while in larvae and adults it is expressed solely in the excretory cell. Homeobox domain ViswanathanM et al 2005 S2 sir-2.1 regulated C37H5.5 Aff_C37H5.5 C37H5.5; C37H5.5.1; C37H5.5.2; 5F313; CE29708; WBGene00016508; WP:CE29708 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C38C10.5 Aff_C38C10.5 mdt-14; rgr-1; C38C10.5; 3K493; CE34528; CE34529; NM_066666; NM_066667; WBGene00004343; WP:CE34528; WP:CE34529 RGR1 (yeast) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C39F7.2 Aff_Y50D4A_25.A C39F7.2; C39F7.2.1; C39F7.2.2; 5B704; CE27581; WBGene00016539; WP:CE27581 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C41G7.3 Aff_C41G7.3 C41G7.3; 1K94; CE08667; WBGene00008061; WP:CE08667 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C42D8.3 Aff_C42D8.3 uvt-3; C42D8.3; CE04204; NM_076465; WBGene00006862; WP:CE04204; XF711 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C43H8.1 Aff_C43H8.1 C43H8.1; C43H8.1.1; C43H8.1.2; 1L201; CE19377; WBGene00016621; WP:CE19377 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C44C8.1 Aff_C44C8.1 C44C8.1; 4B655; CE17541; WBGene00016646; WP:CE17541 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C44E4.4 Aff_C44E4.4 C44E4.4; C44E4.4.1; C44E4.4.2; 1F203; CE08718; WBGene00016653; WP:CE08718 RNA-binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C50A2.4 Aff_C50A2.4 C50A2.4; 4B908; CE17582; WBGene00016798; WP:CE17582 C50B8.3 Aff_C50B8.3 C50B8.3; 5O46; CE08883; WBGene00008225; WP:CE08883 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C50F4.13 Aff_C50F4.13 his-35; C50F4.13; C50F4.13.1; C50F4.13.2; C50F4.13.3; 5K22; CE05477; NM_073062; WBGene00001909; WP:CE05477 his-35 encodes an H2A histone. histone H2A McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated C52B9.8 Aff_C52B9.8 C52B9.8; CE27114; WBGene00016868; WP:CE27114; XE918 helicase ViswanathanM et al 2005 S2 sir-2.1 regulated C54A12.1 Aff_C54A12.1 ptr-6; C54A12.1; 2F534; CE39341; NM_062585; WBGene00004221; WBGene00016908; WP:CE39341 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 C54G4.6 Aff_C54G4.6 dod-18; C54G4.6; 1I594; CE05512; NM_059804; WBGene00008316; WP:CE05512 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. MAF protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C55A6.2 Aff_C55A6.2 C55A6.2; 5L991; CE29733; WBGene00008331; WP:CE29733 Human KIAA0173 protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C55B7.8 Aff_C55B7.8 Ce-dbr1; dbr-1; C55B7.8; 1H68; CE30437; NM_059467; WBGene00000937; WP:CE30437 dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels. lariat debranching enzyme McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated D1007.12 Aff_D1007.12 rpl-24.1; RPL-24; D1007.12; D1007.12.1; D1007.12.2; 1F153; CE09047; NM_058998; WBGene00004436; WP:CE09047 rpl-24.1 encodes a large ribosomal subunit L24 protein. 60S ribosomal protein L24 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated D1014.8 Aff_D1014.8 spr-1; D1014.8; 5I608; CE27749; NM_072697; WBGene00005006; WP:CE27749 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated D2005.5 Aff_D2005.5 drh-3; ekl-3; D2005.5; 1I401; CE36120; WBGene00008400; WP:CE36120 RNA helicase like Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Romagnolo et al 2002 Fig3b Metabolism, ViswanathanM et al 2005 S2 daf-16 Resveratrol D2007.5 Aff_D2007.5 D2007.5; D2007.5.1; D2007.5.2; 3J246; CE00130; WBGene00017045; WP:CE00130 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated D2085.4 Aff_D2085.4 D2085.4; 2I957; CE15744; WBGene00008429; WP:CE15744 similarity with a human hypothetical protein (PIR Acc. No. A38919) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated DY3.4 Aff_DY3.4 trt-1; DY3.4; DY3.4a.1; DY3.4a.2; DY3.4b.1; DY3.4b.2; DY3.4b.3; DY3.4b.4; DY3.4b.5; 1J347; CE15748; CE27901; CETERT; NM_059972; NM_059973; WBGene00006618; WP:CE15748; WP:CE27901 trt-1 encodes C. elegans telomerase reverse transcriptase that affects fertility, maintenance of telomere length, and chromosome nondisjunction. Reverse transcriptase (RNA-dependent DNA polymerase) Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated E02H1.3 Aff_E02H1.3 tag-124; E02H1.3; CE01538; WBGene00006473; WP:CE01538 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. Yeast DEG-1 protein homolog Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated E04F6.3 Aff_E04F6.3 maoc-1; E04F6.3; 2H487; CE01215; WBGene00017123; WP:CE01215 E04F6.3 encodes a protein that is orthologous (with 52% identity over 93% of its length) to residues 334-609 of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE IV (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), a protein of 736 residues whose N- and C-terminal domains are orthologous to DHS-28; E04F6.3 contains a MaoC-like domain, found in diverse enzymes (HSD17B4, peroxisomal hydratase-dehydrogenase-epimerase, and the fatty acid synthase beta subunit); E04F6.3 has no obvious function in mass RNAi assays. Hydratase-dehydrogenase-epimerase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination EEED8.7 Aff_EEED8.7 rsp-4; srp-2; EEED8.7; 2F678; CE01891; CE27910; CeSC35; NM_062612; NM_062613; WBGene00004701; WP:CE01891; WP:CE27910 splicing factor SC35 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F02E8.1 Aff_F02E8.1 asb-2; F02E8.1; F02E8.1.1; F02E8.1.2; CE07016; NM_076369; WBGene00000207; WP:CE07016; XF89 asb-2 encodes a ATP synthase B homolog. ATP synthase B chain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C F02E8.5 Aff_F02E8.5 F02E8.5; CE07020; WBGene00017178; WP:CE07020; XF78 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F08B12.2 Aff_F08B12.2 prx-12; F08B12.2; CE03163; NM_077507; WBGene00004197; WP:CE03163; XM13 Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F08B6.1 Aff_F08B6.F F08B6.1; F08B6.F; 1H339; CE39717; WBGene00017239; WP:CE39717 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F08B6.2 Aff_F08B6.E gpc-2; F08B6.2; F08B6.2.1; F08B6.2.2; F08B6.2.3; 1H335; CE20656; NM_059534; WBGene00001682; WP:CE20656 gpc-2 encodes one of two C. elegans heterotrimeric G protein gamma subunits; gpc-2 is required, along with its partner GPB-1, a G protein beta subunit, for proper mitotic spindle positioning and orientation during early embryonic cell divisions; to date, GPC-2 expression has been reported in electrically excitable cells (all neurons and muscles). ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08C6.4 Aff_F08C6.4 sto-1; F08C6.4; CE27924; NM_076880; WBGene00006063; WP:CE27924; XI183 Erythrocyte band 7 integral membrane protein (human) Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order F08F1.8 Aff_F08F1.8 tth-1; F08F1.8; F08F1.8.1; F08F1.8.2; CE27929; NM_077029; WBGene00006649; WP:CE27929; XJ42 tth-1 encodes a thymosin beta ortholog that contains four functionally distinct thymosin beta repeats; in vitro, TTH-1 binds multiple actin monomers as well as filamentous actin suggesting that, as its homology predicts, TTH-1 plays a direct role in regulating actin polymerization and cytoskeletal organization in C. elegans; consistent with this, loss of tth-1 activity via a deletion mutation that removes upstream sequences results in animals with a dumpy morphology that are sterile as a result of maternal effect lethality associated with deformed oocytes containing abnormally distributed actin; tth-1 mRNA is present throughout development, while TTH-1 protein is detected in the adult gonad in the inside edges of the membranous structures surrounding germline nuclei, the cytoplasm and cortex of oocytes, early embryos at points of cell contact, the developing nerve ring, and then throughout the larval and adult body, with specific enrichment in the intestine and spermatheca. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F09B9.3 Aff_F09B9.3 erd-2; F09B9.3; CE23635; ERD2; NM_077302; WBGene00001331; WP:CE23635; XK776 erd-2 encodes a protein with homology to human ER lumen protein retaining receptor 1. ER lumen protein retaining receptor McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated F09C8.2 Aff_F09C8.2 F09C8.2; F09C8.2.1; F09C8.2.2; CE03178; WBGene00008622; WP:CE03178; XQ756 F09E10.3 Aff_F09E10.3 dhs-25; F09E10.3; CE30939; NM_075881; WBGene00000988; WP:CE30939; XC107 dhs-25 encodes a short-chain dehydrogenase predicted to be mitochondrial. short-chain alcohol dehydrogenase ViswanathanM et al 2005 S2 sir-2.1 regulated F09F7.3 Aff_F09F7.3 F09F7.3; F09F7.3.1; F09F7.3.2; 3G653; CE30653; WBGene00017300; WP:CE30653 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F10D2.10 Aff_F10D2.10 F10D2.10; 5H634; CE32860; WBGene00017335; WP:CE32860 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, fem3 enriched genes, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F11A10.7 Aff_F11A10.2 F11A10.7; 4M851; CE28911; WBGene00008688; WP:CE28911 F11E6.1 Aff_4R79.3 F11E6.1; 4S421; CE20669; CE26698; CE31166; WBGene00008706; WP:CE20669; WP:CE26698; WP:CE31166 F11E6.1 is homologous to to the human gene GLUCOCEREBROSIDASE (GBA; OMIM:606463), which when mutated leads to Gaucher disease. Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, IVb male soma enriched genes, Reinke et al 2004, mixed sperm soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 F12F6.1 Aff_F12F6.1 F12F6.1; 4M351; CE34803; WBGene00008720; WP:CE34803 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F13B9.5 Aff_F13B9.4 ksr-1; sar-2; sur-3; F13B9.5; F13B9.5.1; F13B9.5.2; CE25854; NM_076995; WBGene00002239; WP:CE25854; XI901 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F13E9.13 Aff_F13E9.3 F13G3.10 Aff_F13G3.10 F13G3.10; CE17660; NM_059669; WBGene00008768; WP:CE17660 ViswanathanM et al 2005 S2 sir-2.1 regulated F14H12.4 Aff_F14H12.4 F14H12.4; CE39916; CE39917; WBGene00017472; WP:CE39916; WP:CE39917; XE961 protein kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F18A1.5 Aff_F18A1.5 F18A1.5; F18A1.5.1; F18A1.5.2; 2H955; CE04405; WBGene00017546; WP:CE04405 F18A1.5 encodes the C. elegans ortholog of the replication protein A (RPA) large subunit; by homology, the F18A1.5 gene product is predicted to function as a DNA binding and oligonucleotide oligosaccharide binding (OB) protein that is required for DNA replication, repair, and recombination; large-scale RNAi screens indicate that the product of F18A1.5 is essential for embryonic development, and that in yeast two-hybrid assays interacts with the product of M04F3.1, the RPA medium subunit; in situ hybridization studies indicate that F18A1.5 transcripts are expressed in germ cells. replication factor A McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F18H3.1 Aff_F18H3.1 F18H3.1; CE37505; WBGene00008939; WP:CE37505; XO139 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F19C6.5 Aff_F19C6.5 F19C6.5; CE01558; WBGene00008954; WP:CE01558; XK598 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C F19F10.9 Aff_F19F10.9 F19F10.9; 5I52; CE27372; WBGene00017605; WP:CE27372 The F19F10.9 gene encodes a homolog of the human SART1 gene, which encodes a protein recognised by IgE that may be involved in atopic disease. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F20A1.1 Aff_F20A1.1 F20A1.1; 5H533; CE07091; WBGene00017613; WP:CE07091 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order F22F7.1 Aff_F22F7.1 F22F7.1; F22F7.1a.1; F22F7.1a.2; 5C603; CE17691; CE32871; WBGene00017719; WP:CE17691; WP:CE32871 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F23A7.4 Aff_F23A7.4 F23A7.4; CE09578; WBGene00009069; WP:CE09578; XQ825 glutamate receptor epsilon subunit like ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F23C8.6 Aff_F23C8.F phi-24; F23C8.6; F23C8.F; 1C988; CE20715; WBGene00017735; WP:CE20715 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F23H11.1 Aff_F23H11.1 bra-2; tag-285; F23H11.1; 3B529; CE09609; NM_064891; WBGene00017757; WP:CE09609 The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F23H11.5 Aff_F23H11.5 F23H11.5; F23H11.5.1; F23H11.5.2; F23H11.5.3; 3B528; CE09613; WBGene00000263; WP:CE09613 The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway. ViswanathanM et al 2005 S2 sir-2.1 regulated F26F4.11 Aff_F26F4.11 F26F4.11; 3G6; CE04448; WBGene00017830; WP:CE04448 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F26H11.2 Aff_F26H11.2 nurf-1; F26H11.2; F26H11.2a.1; F26H11.2a.2; 2O693; CE15909; CE15910; CE35294; CE35295; CE35296; CE36931; CE37638; WBGene00009180; WP:CE15909; WP:CE15910; WP:CE35294; WP:CE35295; WP:CE35296; WP:CE36931; WP:CE37638 Bromodomain Kwon et al 2004 T1 transient-induction Ethanol-res, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, IVb male soma enriched genes F28C6.10 Aff_F28C6.10 F28C6.10; 2I899; CE09747; WBGene00009209; WP:CE09747 Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes F28F8.3 Aff_F28F8.3 lsm-5; F28F8.3; F28F8.3.1; F28F8.3.2; 5Q49; CE09757; NM_074469; WBGene00003079; WP:CE09757 small nuclear ribonucleoprotein E (SNRNP-E) like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F31C3.1 Aff_F31C3.1 cyn-5; cyp-5; F31C3.1; F31C3.1.1; F31C3.1.2; 1P632; CE17730; NM_061223; WBGene00000881; WP:CE17730 cyp-5 encodes a cyclophilin that is functional in vitro and is predicted to be a secreted protein that is structurally most similar to human cyclophilin B; expressed in the intestine. cyclophillin McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F31D4.1 Aff_F31D4.1 F31D4.1; 5V311; CE31921; WBGene00009289; WP:CE31921 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F32E10.2 Aff_F32E10.2 F32E10.2; 4I341; CE04475; WBGene00017990; WP:CE04475 chromo domain of heterochromatin protein Jiang et al 2001 Fig1 hermaphrodite-enriched TF, Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories F33E11.1 Aff_F33E11.1 nhr-15; F33E11.1; 5A799; CE17759; NM_070773; WBGene00003614; WP:CE17759 nhr-15 is predicted to encode a member of the nuclear hormone receptor family. nuclear hormone receptor Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F34D10.3 Aff_F34D10.3 F34D10.3; 3E825; CE00963; WBGene00009373; WP:CE00963 F36A2.6 Aff_F36A2.6 rps-15; F36A2.6; F36A2.6.1; F36A2.6.2; 1J392; CE09945; NM_059983; WBGene00004484; WP:CE09945 rps-15 encodes a small ribosomal subunit S15 protein. 40S ribosomal protein S15 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F36A2.7 Aff_F36A2.7 F36A2.7; F36A2.7.1; F36A2.7.2; 1J391; CE09946; WBGene00009454; WP:CE09946 ViswanathanM et al 2005 S2 sir-2.1 regulated F36A4.8 Aff_F36A4.8 F36A4.8; F36A4.8.1; F36A4.8.2; 4F11; CE07184; WBGene00018085; WP:CE07184 F37C12.11 Aff_F37C12.11 rps-21; F37C12.11; F37C12.11.1; F37C12.11.2; 3I278; CE30779; NM_066178; WBGene00004490; WP:CE30779 rps-21 encodes a small ribosomal subunit S21 protein; by homology, RPS-21 is predicted to function in protein biosynthesis; in C. elegans, RPS-21 activity is required for embryonic and germline development, as well as the overall health of the animal. Ribosomal protein S21 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F37C12.4 Aff_F37C12.4 rpl-36; F37C12.4; F37C12.4.1; F37C12.4.2; F37C12.4.3; 3I271; CE30781; NM_066172; WBGene00004450; WP:CE30781 rpl-36 encodes a large ribosomal subunit L36 protein; by homology, RPL-36 is predicted to function in protein biosynthesis; in C. elegans, RPL-36 activity is required for embryonic and germline development and normal postembryonic growth rates. Ribosomal protein YL39 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F37C12.9 Aff_F37C12.9 rps-14; F37C12.9; F37C12.9.1; F37C12.9.2; 3I268; CE00821; NM_066171; WBGene00004483; WP:CE00821 rps-14 encodes a small ribosomal subunit S14 protein; by homology, RPS-14 is predicted to function in protein biosynthesis; in C. elegans, RPS-14 activity is required for embryonic and germline development, as well as the overall health of the animal. Ribosomal protein S14 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F37E3.1 Aff_F37E3.1 F37E3.1; 1H1; CE29793; WBGene00018156; WP:CE29793 CAP-binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F38A6.1 Aff_F38A6.1 Ce-fkh-1; fkh-1; pha-4; F38A6.1; 5V229; CE15998; NM_075605; WBGene00004013; WP:CE15998 Fork head domain, eukaryotic transcription factors Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F39B2.6 Aff_F39B2.6 rps-26; F39B2.6; F39B2.6.1; F39B2.6.2; 1P353; CE16012; NM_061170; WBGene00004495; WP:CE16012 rps-26 encodes a small ribosomal subunit S26 protein; by homology, RPS-26 is predicted to function in protein biosynthesis; in C. elegans, RPS-26 activity is required for embryonic, larval, and germline development, as well as normal locomotion and body morphology. 40S ribosomal protein S26 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F39G3.7 Aff_F39G3.7 pex-6; prx-6; F39G3.7; 5F194; CE10124; NM_071867; WBGene00004195; WP:CE10124 ATPase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F40F11.1 Aff_F40F11.1 rps-11; F40F11.1; F40F11.1.1; F40F11.1.2; 4M367; CE05860; NM_069785; WBGene00004480; WP:CE05860 rps-11 encodes a small ribosomal subunit S11 protein; by homology, RPS-11 is predicted to function in protein biosynthesis; in C. elegans, RPS-11 activity is required for embryonic and germline development, as well as the overall health of the animal. ribosomal protein S11 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F40F8.10 Aff_F40F8.10 rps-9; F40F8.10; F40F8.10.1; F40F8.10.2; F40F8.10.3; 2L416; CE05849; NM_063983; WBGene00004478; WP:CE05849 rps-9 encodes a small ribosomal subunit S9 protein. ribosomal protein S9 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F42C5.8 Aff_F42C5.8 rps-8; F42C5.8; F42C5.8.1; F42C5.8.2; 4I78; CE04561; NM_068766; WBGene00004477; WP:CE04561 rps-8 encodes a small ribosomal subunit S8 protein; by homology, RPS-8 is predicted to function in protein biosynthesis; in C. elegans, RPS-8 activity is required for germline development and the overall health of the animal. 40S ribosomal protein S8 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F42G2.6 Aff_F42G2.6 F42G2.6; 2C718; CE32659; WBGene00018355; WP:CE32659 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol F42G9.2 Aff_F42G9.2 cyn-6; cyp-6; F42G9.2; 3B391; CE01301; NM_064856; WBGene00000882; WP:CE01301 cyp-6 encodes a cyclophilin most similar to human secreted cyclophilin type B isoforms that is functional when expressed in E. coli; it is expressed in the intestine. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F44F1.6 Aff_F44F1.6 F44F1.6; 1N854; CE23728; CE23729; WBGene00009698; WP:CE23728; WP:CE23729 ViswanathanM et al 2005 S2 daf-16 Resveratrol F45H10.4 Aff_F45H10.4 drr-1; F45H10.4; 2N786; CE10548; WBGene00009741; WP:CE10548 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F47A4.2 Aff_F47A4.2 dpy-22; mdt-12; psa-6; sop-1; F47A4.2; CE16058; NM_077244; WBGene00001081; WP:CE16058; XK430 dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation; DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression. Reinke et al 2004, wt herm vs wt male enriched gen F47D12.6 Aff_F47D12.6 F47D12.6; 3H376; CE01950; WBGene00018562; WP:CE01950 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F48E3.6 Aff_F48E3.6 F48E3.6; CE02753; WBGene00018606; WP:CE02753; XI120 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E F49C12.9 Aff_F49C12.9 F49C12.9; 4K80; CE10780; WBGene00009878; WP:CE10780 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F52B5.6 Aff_F52B5.6 rpl-25.2; F52B5.6; F52B5.6.1; F52B5.6.2; 1I906; CE05721; NM_059862; WBGene00004439; WP:CE05721 rpl-25.2 encodes a large ribosomal subunit L23a protein. 60S ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated F52H3.3 Aff_F52H3.3 bath-38; F52H3.3; 2K334; CE03399; WBGene00009945; WP:CE03399 BTB (also known as BR-C/Ttk) domain. F53B7.3 Aff_F53B7.3 F53B7.3; 5L480; CE05922; WBGene00009966; WP:CE05922 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F53C11.3 Aff_F53C11.3 F53C11.3; 5O263; CE10908; WBGene00009973; WP:CE10908 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. 2,4-dienoyl-CoA reductase ViswanathanM et al 2005 S2 sir-2.1 regulated F53F10.2 Aff_F53F10.2 F53F10.2; F53F10.2a.1; F53F10.2a.2; F53F10.2a.3; F53F10.2b.1; F53F10.2b.2; F53F10.2b.3; F53F10.2b.4; 1E401; CE10982; CE30374; WBGene00018764; WP:CE10982; WP:CE30374 decarbaxylase ViswanathanM et al 2005 S2 sir-2.1 regulated F53G12.10 Aff_F53G12.10 rpl-7; F53G12.10; F53G12.10.1; F53G12.10.2; 1A583; CE11024; NM_058275; WBGene00004418; WP:CE11024 rpl-7 encodes a large ribosomal subunit L7 protein required in mass RNAi assays for embryonic viability and normally rapid growth. ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F53H1.1 Aff_Y104H12B_374.A F53H1.1; 4C62; CE27427; WBGene00018776; WP:CE27427 helicase Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F54B11.6 Aff_F54B11.6 bra-1; F54B11.6; CE05930; NM_077876; WBGene00000262; WBGene00010029; WP:CE05930; XO217 The bra-1 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1) that negatively regulates the DAF-1/DAF-7/DAF-14 TGF-beta signalling pathway. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F54E12.2 Aff_F54E12.2 F54E12.2; F54E12.2.1; F54E12.2.2; 4M98; CE11083; WBGene00010061; WP:CE11083 helicase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F54E7.2 Aff_F54E7.2 rps-12; F54E7.2; F54E7.2.1; F54E7.2.2; 3G769; CE26896; NM_065820; WBGene00004481; WP:CE26896 rps-12 encodes a small ribosomal subunit S12 protein; by homology, RPS-12 is predicted to function in protein biosynthesis; in C. elegans, RPS-12 activity is required for embryonic and germline development, normal movement, and the overall health of the animal. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F55A8.1 Aff_F55A8.1 egl-18; elt-5; pvl-3; F55A8.1; F55A8.1.1; F55A8.1.2; F55A8.1.3; 4C681; CE28339; NM_067742; WBGene00001186; WP:CE28339 egl-18 encodes a member of the GATA-family of transcription factors that affects cell migration, cell fate specification; expressed in the head, in hypodermal seam cells, VC neurons, and vulval precursor cells. zinc finger protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F55B11.1 Aff_F55B11.1 F55B11.1; 4P166; CE16116; WBGene00010083; WP:CE16116 The F55B11.1 gene encodes an ortholog of the human gene XANTHINE DEHYDROGENASE (XDH), which when mutated leads to xanthinuria (OMIM:278300). xanthine dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F56A6.2 Aff_F56A6.2 hum-7; F56A6.2; 1B60; CE23779; NM_058354; WBGene00002040; WP:CE23779 hum-7 encodes a class IX unconventional myosin heavy chain that contains a myosin motor domain in the head region and zinc-finger and rhoGAP (rho GTPase activating protein) domains in the tail region; HUM-7 is required during embryogenesis for cytokinesis and normal cytoplasmic rearrangements, and by homology, may function in organization of the actin cytoskeleton; the precise expression and localization patterns of HUM-7 are not yet known. myosin ViswanathanM et al 2005 S2 sir-2.1 regulated F56A6.4 Aff_Y65B4A_175.A F56A6.4; 1B88; CE34319; WBGene00018923; WP:CE34319 ViswanathanM et al 2005 S2 sir-2.1 regulated F57B10.10 Aff_F57B10.10 dad-1; F57B10.10; F57B10.10.1; F57B10.10.2; 1H132; CE11316; NM_059488; WBGene00000896; WP:CE11316 dad-1 encodes an ortholog of human DAD1 (OMIM:600243) that inhibits cell death and can functionally complement the hamster protein in cultured cells. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F57B10.8 Aff_F57B10.8 F57B10.8; 1H124; CE11312; WBGene00019005; WP:CE11312 Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset F57F4.3 Aff_F57F4.3 gfi-1; F57F4.3; 5G882; CE11342; NM_072225; WBGene00001581; WP:CE11342 gfi-1 encodes a protein that contains 21 ET modules; interacts with unc-68 in yeast two-hybrid assays. Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C F58B3.4 Aff_F58B3.4 F58B3.4; 4M394; CE36170; WBGene00010231; WP:CE36170 Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated F59A6.6 Aff_F59A6.6 rnh-1; F59A6.6; F59A6.6b.1; F59A6.6b.2; 2F287; CE33406; CE33659; NM_062519; NM_182182; WBGene00004382; WP:CE33406; WP:CE33659 rnh-1 encodes a putative RNAse H that is predicted, by phylogenetic profiling, to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated H06I04.4 Aff_Y53G8B_1025.B ubl-1; H06I04.4; H06I04.4a.1; H06I04.4a.2; H06I04.4a.3; H06I04.4b.1; H06I04.4b.2; 3E159; CE20938; CE31022; NM_171089; WBGene00006725; WP:CE20938; WP:CE31022 ubl-1 encodes a protein similar to Drosophila ubiquitin/ ribosomal protein S27a that affects body length, fertility, and larval viability. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated H24K24.5 Aff_H24K24.B fmo-15; fmo-5; H24K24.5; 5B378; CE20989; NM_070951; WBGene00001480; WP:CE20989 fmo-15 encodes a flavin-containing monooxygenase (FMO) homologous to various human FMOs mutated in trimethylaminuria (OMIM:602079). flavin-containing monooxygenase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 K01G5.8 Aff_K01G5.8 K01G5.8; K01G5.8a.1; K01G5.8a.2; 3L830; CE16198; CE16199; WBGene00010479; WP:CE16198; WP:CE16199 ViswanathanM et al 2005 S2 sir-2.1 regulated K02B2.5 Aff_K02B2.5 rps-25; K02B2.5; K02B2.5.1; K02B2.5.2; 4G712; CE04691; NM_068494; WBGene00004494; WP:CE04691 rps-25 encodes a small ribosomal subunit S25 protein. ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K02E7.6 Aff_K02E7.6 K02E7.6; K02E7.6.1; K02E7.6.2; 2B349; CE33417; WBGene00019311; WP:CE33417 Reinke et al 2004, IVb male soma enriched genes, Shen et al 2005 T1 hif-1 depend hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated K02F3.4 Aff_K02F3.4 zip-2; K02F3.4; K02F3.4.1; K02F3.4.2; 3B453; CE23848; WBGene00019327; WP:CE23848 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K03B4.7 Aff_K03B4.7 K03B4.7; K03B4.7a.1; K03B4.7a.2; 5F170; CE28581; CE33133; WBGene00019357; WP:CE28581; WP:CE33133 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, IVb male soma enriched genes, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched K03H1.7 Aff_K03H1.7 K03H1.7; 3L37; CE00573; WBGene00010542; WP:CE00573 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K04C2.2 Aff_K04C2.2 K04C2.2; 3H983; CE00722; WBGene00019380; WP:CE00722 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA K04D7.3 Aff_K04D7.3 gta-1; K04D7.3; 4K947; CE06092; NM_069461; WBGene00001794; WP:CE06092 The gta-1 gene encodes an ortholog of the human gene GABAT, which when mutated leads to GABA-transaminase deficiency (OMIM:137150). 4-aminobutyrate aminotransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K07A1.11 Aff_K07A1.11 rba-1; K07A1.11; 1K194; CE11860; NM_060150; WBGene00004312; WP:CE11860 retinablastoma-binding protein RBAP46 like Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K07A1.12 Aff_K07A1.12 lin-53; rba-2; K07A1.12; K07A1.12.1; K07A1.12.2; 1K196; CE16234; NM_060151; WBGene00003036; WP:CE16234 chromatin assembly factor 1 P55 subunit like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K07C5.6 Aff_K07C5.6 K07C5.6; K07C5.6.1; K07C5.6.2; 5K834; CE06116; WBGene00010629; WP:CE06116 Zinc finger, CCHC class McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated K08D10.3 Aff_K08D10.3 rnp-3; K08D10.3; 4E939; CE07355; NM_068104; WBGene00004386; WP:CE07355 U1 small nuclear ribonucleoprotein A McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K08E3.8 Aff_K08E3.8 mdt-29; K08E3.8; K08E3.8.1; K08E3.8.2; 3O867; CE18874; NM_067446; WBGene00007025; WP:CE18874 mdt-29 encodes a putative mediator subunit with a prion-like (asparagine- or glutamine-rich) domain; note that K08E3.8 is allegedly an ortholog of Drosophila INTERSEX/IX, but the actual C. elegans IX ortholog appears to be PQN-15); in yeast two-hybrid screens, MDT-29 interacts with SEL-7 and SEL-8; MDT-29 protein also self-associates; RNAi of K08E3.8 weakly enhances the two-anchor-cell phenotype of lin-12(ar170), roughly as much as sel-7 RNAi; since SEL-7 is a novel nuclear protein, MDT-29/SEL-7/SEL-8 is likely to form a nuclear complex formed in response to LIN-12 activation. ViswanathanM et al 2005 S2 sir-2.1 regulated K08H2.1 Aff_K08H2.1 skr-21; K08H2.1; CE06159; NM_077793; WBGene00004827; WP:CE06159; XN844 The skr-21 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-21(RNAi) animals are at least superficially normal. RNA polymerase II elongation factor like K11H12.2 Aff_K11H12.2 rpl-15; K11H12.2; K11H12.2.1; K11H12.2.2; K11H12.2.3; K11H12.2.4; 4B406; CE12148; NM_067563; WBGene00004427; WP:CE12148 rpl-15 encodes a large ribosomal subunit L15 protein. 60S ribosomal protein L15 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K12C11.2 Aff_K12C11.2 smo-1; K12C11.2; 1B815; CE18056; NM_058441; SMT3; WBGene00004888; WP:CE18056 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K12H4.3 Aff_K12H4.3 K12H4.3; 3J135; CE00268; WBGene00019678; WP:CE00268 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA M01F1.2 Aff_M01F1.2 rpl-16; M01F1.2; M01F1.2.1; M01F1.2.2; 3E592; CE01030; NM_065320; WBGene00004428; WP:CE01030 rpl-16 encodes a large ribosomal subunit L13a protein. L13P family ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R02F11.4 Aff_R02F11.4 R02F11.4; 5F290; CE12502; WBGene00019842; WP:CE12502 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated R03E1.2 Aff_R03E1.2 R03E1.2; R03E1.2.1; R03E1.2.2; CE18902; WBGene00010993; WP:CE18902; XO782 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 R05D11.7 Aff_R05D11.7 R05D11.7; 1J179; CE06242; WBGene00011035; WP:CE06242 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated R05H5.3 Aff_R05H5.3 R05H5.3; 2K489; CE02290; WBGene00011038; WP:CE02290 thioredoxin Golden et al 2004, N2 vs daf-2 different genes at , Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R06A4.8 Aff_R06A4.8 R06A4.8; 2O638; CE18115; WBGene00011050; WP:CE18115 R06A4.8 is orthologous to the human gene GLYCOGEN DEBRANCHING ENZYME ISOFORM 6 (AGL; OMIM:232400), which when mutated leads to glycogen storage disease, type III. Alpha amylase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol R07G3.3 Aff_R07G3.3 npp-21; R07G3.3; 2H897; CE37543; CE37544; WBGene00019940; WP:CE37543; WP:CE37544 myosin heavy chain Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated R09B3.5 Aff_R09B3.5 mag-1; R09B3.5; R09B3.5.1; R09B3.5.2; 1M504; CE16310; NM_060624; WBGene00003123; WP:CE16310 MAGO NASHI PROTEIN McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R11D1.8 Aff_R11D1.8 rpl-28; R11D1.8; R11D1.8.1; R11D1.8.2; R11D1.8.3; R11D1.8.4; R11D1.8.5; 5N208; CE06313; NM_073779; WBGene00004442; WP:CE06313 rpl-28 encodes a large ribosomal subunit L28 protein. ribsomal protein L28 like R11E3.6 Aff_R11E3.6 eor-1; R11E3.6; R11E3.6.1; R11E3.6.2; R11E3.6.3; 4F558; CE19548; NM_068244; WBGene00001324; WP:CE19548 eor-1 encodes an ortholog of the human BTB/zinc-finger transcription factor PLZF (OMIM:176797), which is is found as a retinoic acid receptor alpha (RARA) fusion in acute promyelocytic leukemia (APL); EOR-1 positively regulates RAS/RAF-mediated signalling during excretory system development, as well as RAS/RAF- and WNT-mediated signalling during P12 fate specification; EOR-1 may function with EOR-2 and Hox genes to control the expression of Ras- and Wnt-responsive genes. zinc-finger protein Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol R12H7.3 Aff_R12H7.3 skr-19; R12H7.3; CE03568; NM_077792; WBGene00004825; WP:CE03568; XN842 The skr-19 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-19(RNAi) animals are at least superficially normal. RNA polymerase II elongation factor like ViswanathanM et al 2005 S2 sir-2.1 regulated R13F6.1 Aff_R13F6.1 kbp-1; R13F6.1; 3H959; CE00720; NM_066094; WBGene00020064; WP:CE00720 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R151.3 Aff_R151.3 rpl-6; R151.3; R151.3.1; R151.3.2; 3I299; CE00744; NM_066183; WBGene00004417; WP:CE00744 rpl-6 encodes a large ribosomal subunit L6 protein. Ribosomal protein ML16 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated R151.9 Aff_R151.9 R151.9; 3H288; 3I288; CE00827; WBGene00020112; WP:CE00827 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T01B11.2 Aff_T01B11.2 T01B11.2; 4J214; CE12894; CE33686; WBGene00020139; WP:CE12894; WP:CE33686 aminotransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 T02G5.7 Aff_T02G5.7 T02G5.7; CE04859; NM_063055; WBGene00020166; WP:CE04859 The T02G5.7 gene encodes a homolog of the human gene ACAT1, which when mutated leads to alpha-methylacetoaceticaciduria (OMIM:203750). acetoacetyl CoA thiolase ReichertK et al 2005 T3 xenobiotic downregulated, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 T03F6.1 Aff_T03F6.1 qdpr-1; T03F6.1; 3O483; CE16335; WBGene00011398; WP:CE16335 The T03F6.1 gene encodes an ortholog of the human gene QUINOID DIHYDROPTERIDINE REDUCTASE (QDPR; DHPR), which when mutated leads to phenylketonuria II (OMIM:261630). Alcohol/other dehydrogenases, short chain type McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T04C10.1 Aff_T04C10.1 mbk-1; T04C10.1; CE33442; NM_078059; WBGene00003149; WP:CE33442; XP440 mbk-1 encodes a putative dual-specificity kinase (predicted to have both serine/threonine and tyrosine substrates) that is orthologous to Drosophila MINIBRAIN and mammalian DYRK1A/MnbK and that has a glutamine/asparagine-rich domain; MBK-1 is found in most or all nuclei, is dispensable for viability, and perturbs olfaction in AWC when overexpressed. serine/threonine kinase (2 domains) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T04C12.5 Aff_T04C12.5 act-2; T04C12.5; 5L558; CE13150; NM_073417; WBGene00000064; WP:CE13150; act2 act-2 encodes an invertebrate actin that may function specifically in the pharynx. actin ViswanathanM et al 2005 S2 sir-2.1 regulated T05E11.1 Aff_T05E11.1 rps-5; T05E11.1; T05E11.1.1; T05E11.1.2; 4L874; CE06360; NM_069676; WBGene00004474; WP:CE06360 rps-5 encodes a small ribosomal subunit S5 protein. 40S ribosomal protein S5 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T05F1.3 Aff_T05F1.3 rps-19; T05F1.3; T05F1.3.1; T05F1.3.2; 1K202; CE13265; NM_060154; WBGene00004488; WP:CE13265; rpS19 rps-19 encodes a small ribosomal subunit S19 protein, orthologous to human RPS19 (OMIM:603474, mutated in Diamond-Blackfan anemia). Ribosomal protein S19e McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T06E4.3 Aff_T06E4.3 Ce-atl1; atl-1; T06E4.3; 5K116; CE25103; CE28250; NM_073086; WBGene00000226; WP:CE25103; WP:CE28250 The atl-1 gene encodes a large, 2514-residue protein of the ATM family, homologous to human AT (OMIM:208900, mutated in ataxia telangiectasia); the C-terminal sequence of ATL-1 contains a PI-3 kinase-like domain; ATL-1 is required for survival through early embryogenesis and normal chromosomal segregation; atl-1 is expressed in both the mitotic and meiotic cells of adult gonads. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes T06E6.2 Aff_T06E6.2 cyb-2; cyb-3; T06E6.2; T06E6.2a.1; T06E6.2a.2; 5P877; CE13315; CE27776; NM_074424; WBGene00000868; WP:CE13315; WP:CE27776 cyb-3 encodes a member of the cyclin B family that is required for embryonic viability, and may be involved with sister chromatid segregation. Jiang et al 2001 Fig2 cyclin-genes, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T07A9.10 Aff_T07A9.10 T07A9.10; 4B145; CE17219; WBGene00020298; WP:CE17219 acetylcholine regulator Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T07C4.2 Aff_T07C4.2 tbx-8; T07C4.2; 3L437; CE36891; NM_066886; WBGene00006545; WP:CE36891 Brachyury Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes T07C4.4 Aff_T07C4.4 spp-1; T07C4.4; T07C4.4.1; T07C4.4.2; 3L444; CE35363; NM_066889; WBGene00004986; WP:CE35363 spp-1 encodes a predicted transmembrane protein containing a saposin (B) domain that is a member of a saposin-like protein superfamily containing mammalian NK-lysin and granulysin and the protozoan amoebapores; SPP-1 is predicted to function as a lipid-binding protein with cytotoxic, pore-forming activity, and in vitro, does exhibit antibacterial activity; loss of SPP-1 function via RNA-mediated interference (RNAi) does not, however, result in any abnormalities. ViswanathanM et al 2005 S2 sir-2.1 regulated T07C4.6 Aff_T07C4.6 tbx-9; T07C4.6; T07C4.6.1; T07C4.6.2; 3L430; CE36892; NM_066885; WBGene00006546; WP:CE36892 Brachyury Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E T07C4.9 Aff_T07C4.9 nex-2; T07C4.9; T07C4.9b.1; T07C4.9b.2; 3L416; CE23956; CE35364; WBGene00003589; WP:CE23956; WP:CE35364 nex-2 encodes an annexin, a member of a family of calcium-dependent phospholipid binding proteins; by homology, NEX-2 could function in a number of processes, such as membrane fusion, cytoskeletal interactions, and intracellular signaling; however, as loss of nex-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of NEX-2 in C. elegans development and/or behavior is not yet known. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T10C6.5 Aff_T10C6.5 T10C6.5; 5Q503; CE16380; WBGene00011687; WP:CE16380 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T12D8.1 Aff_T12D8.1 tag-350; T12D8.1; 3O745; CE16398; WBGene00011729; WP:CE16398 PHD-finger. (2 domains), SET domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order T13A10.11 Aff_T13A10.11 tag-32; T13A10.11; T13A10.11a.1; T13A10.11a.2; 4H42; CE30175; CE31726; WBGene00006416; WBGene00020470; WP:CE30175; WP:CE31726 S-adenosylmethionine synthetase Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 sir-2.1 regulated T13F2.7 Aff_T13F2.7 T13F2.7; 4K540; CE13631; WBGene00011747; WP:CE13631 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T20B12.8 Aff_T20B12.8 hmg-4; T20B12.8; 3I470; CE01414; NM_066232; WBGene00001974; WP:CE01414 hmg-4 encodes a protein with strong similarity to the highly conserved high mobility group protein SSRP1 (structure-specific DNA recognition protein); by homology, HMG-4 is predicted to be a member of the FACT (facilitates chromatin transcription) complex that functions as a transcription elongation factor; RNAi experiments indicate that hmg-4 is required for locomotion and larval development, and required redundantly with hmg-3, its paralog, for embryonic development. Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T22C1.11 Aff_T22C1.11 T22C1.11; 1I544; CE24001; WBGene00011920; WP:CE24001 ViswanathanM et al 2005 S2 sir-2.1 regulated T22D1.11 Aff_T22D1.11 T22D1.11; 4H692; CE17255; WBGene00020688; WP:CE17255 carboxyesterase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, herm soma enriched genes, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T23G7.3 Aff_T23G7.3 T23G7.3; 2J456; CE03704; WBGene00011966; WP:CE03704 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T24B8.1 Aff_T24B8.1 rpl-32; T24B8.1; T24B8.1.1; T24B8.1.2; T24B8.1.3; T24B8.1.4; 2J346; CE03709; NM_063533; WBGene00004446; WP:CE03709 rpl-32 encodes a large ribosomal subunit L32 protein. 60S ribosomal protein L32 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T24C4.1 Aff_T24C4.1 T24C4.1; 3B499; CE19592; WBGene00020757; WP:CE19592 T24C4.1 encodes an ubiquinol-cytochrome C reductase complex core protein 2 ortholog, predicted by Eisenberg and coworkers to be mitochondrial, and required for germline maintenance in mass RNAi assays. Ubiquinol-cytochrome C reductase complex core protein 2 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated T27F2.1 Aff_T27F2.1 skp-1; T27F2.1; T27F2.1.1; T27F2.1.2; 5M129; CE06519; NM_073549; WBGene00004806; WP:CE06519 Drosophila puff specific protein BX42 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T28C6.3 Aff_T28C6.3 T28C6.3; 4J585; CE03748; WBGene00012119; WP:CE03748 ViswanathanM et al 2005 S2 daf-16 Resveratrol W01B11.3 Aff_W01B11.3 W01B11.3; 1D835; CE18307; WBGene00020915; WP:CE18307 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA W03D8.2 Aff_W03D8.2 W03D8.2; 1D368; CE18322; WBGene00020985; WP:CE18322 ser/thr protein phosphatase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, fem3 enriched genes W05G11.2 Aff_W05G11.2 W05G11.2; 3A675; CE39797; WBGene00021040; WP:CE39797 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated W06E11.2 Aff_W06E11.2 W06E11.2; 3B259; CE01427; WBGene00021062; WP:CE01427 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated W07E6.2 Aff_W07E6.2 W07E6.2; 2A772; CE17294; WBGene00021074; WP:CE17294 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA W08D2.4 Aff_W08D2.4 fat-3; W08D2.4; 4K569; CE25153; NM_069351; WBGene00001395; WP:CE25153 The fat-3 gene encodes a delta-6 fatty acid desaturase ('linoleoyl-CoA desaturase') containing an N-terminal cytochrome b5 domain; FAT-3 expressed in yeast uses linoleic and alpha-linolenic acid as substrates; FAT-3 is absolutely required in vivo for synthesis of delta-6 fatty acids, and also required for fully normal synthesis of C20 fatty acids; FAT-3 is required for a normally fast growth rate and movement speed, and for normal defecation rhythms and fertility. Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated W09C2.1 Aff_W09C2.1 elt-1; W09C2.1; W09C2.1a.1; W09C2.1a.2; 4K383; CE03799; CE39113; NM_069307; WBGene00001249; WP:CE03799; WP:CE39113 The elt-1 gene encodes a GATA transcription factor expressed in the embryonic hypodermis, and is essential for the production of most hypodermal cells. elongation factor ELT Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes W09H1.5 Aff_W09H1.5 W09H1.5; 2N476; CE16575; WBGene00012375; WP:CE16575 Zinc-binding dehydrogenases McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y105C5B.9 Aff_Y105C5.FF Y105C5B.9; 4Q695; CE24085; WBGene00013650; WP:CE24085 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y105E8B.5 Aff_Y105E8A.K Y105E8B.5; 1P253; CE24099; WBGene00013690; WP:CE24099 The Y105E8B. Y105E8B.6 Aff_Y105E8A.M Y105E8B.6; 1P255; CE24100; WBGene00013691; WP:CE24100 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated Y106G6H.3 Aff_Y106G6H.3 rpl-30; Y106G6H.3; 1L13; CE20413; NM_060327; WBGene00004444; WP:CE20413 rpl-30 encodes a large ribosomal subunit L30 protein; by homology, RPL-30 is predicted to function in protein biosynthesis; in C. elegans, loss of rpl-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated Y37E11AM.1 Aff_Y37E11A_93.F Y37E11AM.1; 4E499; CE33853; WBGene00021365; WP:CE33853 The Y37E11AM.1 gene encodes a DEAH helicase orthologous to the Drosophila CG12211 protein. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y39A1A.6 Aff_Y39A1A.6 Y39A1A.6; 3L707; CE19125; WBGene00012645; WP:CE19125 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y39G10AR.14 Aff_Y39G10A_246.G mcm-4; Y39G10AR.14; Y39G10AR.14.1; Y39G10AR.14.2; 1C888; CE21767; NM_058561; WBGene00003156; WP:CE21767 mcm-4 encodes a member of the MCM2/3/5 family with similarity to human MCM4 minichromosome maintenance deficient 4 protein, and affects embryonic viability, nuclear morphology in early embryos, and larval viability. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated Y39G8B.1 Aff_Y39G8B.E Y39G8B.1; 2O262; CE21733; CE24243; WBGene00012722; WP:CE21733; WP:CE24243 ViswanathanM et al 2005 S2 sir-2.1 regulated Y45F10D.12 Aff_Y45F10D.12 rpl-18; Y45F10D.12; Y45F10D.12.1; Y45F10D.12.2; 4O543; CE16650; NM_070254; WBGene00004430; WP:CE16650 rpl-18 encodes a large ribosomal subunit L18 protein. Eukaryotic ribosomal protein L18 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y47G6A.20 Aff_Y47G6A_245.G rnp-6; Y47G6A.20; 1E108; CE24365; CE24366; CE31375; NM_058775; NM_058776; NM_170843; WBGene00004389; WP:CE24365; WP:CE24366; WP:CE31375 rnp-6 encodes an ortholog of HALF-PINT in D. melanogaster and FBP Interacting Repressor (FIR)/PUF60 in mammals, predicted to be involved in mRNA splicing regulation, mRNA localization, or transcriptional regulation via TFIIH. Y48B6A.6 Aff_Y48B6A.G Y48B6A.6; Y48B6A.6a.1; Y48B6A.6a.2; Y48B6A.G; 2O479; CE32970; CE32971; WBGene00012980; WP:CE32970; WP:CE32971 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y48G8AL.8 Aff_Y48G8A_3945.C rpl-17; Y48G8AL.8; Y48G8AL.8a.1; Y48G8AL.8a.2; Y48G8AL.8a.3; Y48G8A_3945.C; 1B631; CE22195; CE30023; NM_170799; NM_171832; WBGene00004429; WP:CE22195; WP:CE30023 rpl-17 encodes a large ribosomal subunit L17 protein; by homology, RPL-17 is predicted to function in protein biosynthesis; in C. elegans, RPL-17 activity is required for embryonic and germline development, as well as normal postembryonic growth rates. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Zhang et al 2002, T1 mec-3 dependent genes Y53F4B.9 Aff_Y53F4B.M Y53F4B.9; Y53F4B.M; Y53F4B.N; 2P292; CE22399; WBGene00013156; WP:CE22399 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order Y54E10A.15 Aff_Y54E10A_156.A cdt-1; Y54E10A.15; 1D792; CE22447; NM_058725; NM_182086; WBGene00000413; WP:CE22447 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes Y54G2A.36 Aff_Y94H6A_148.S Y54G2A.36; 4D661; CE34417; WBGene00021898; WP:CE34417 Y55B1AL.2 Aff_Y55B1A_122.B Y55B1AL.2; 3B194; CE22497; WBGene00021904; WP:CE22497 Y55B1AL.2 encodes an ortholog of human GENERAL TRANSCRIPTION FACTOR IIH, POLYPEPTIDE 5 (GTF2H5; OMIM:608780, mutated in DNA repair-deficient trichothiodystrophy, complementation group A) and of YDR079C-A (also known as NDR019C) in S. cerevisiae; Y55B1AL.2 is a small protein of ancient origin with other orthologs in plants and Schizosaccharomyces pombe. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57G11C.16 Aff_Y57G11C.16 rps-18; Y57G11C.16; Y57G11C.16.1; Y57G11C.16.2; Y57G11C.16.3; Y57G11C.16.4; 4P591; CE14956; NM_070393; WBGene00004487; WP:CE14956 rps-18 encodes a small ribosomal subunit S18 protein. ribosomal protein S13 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y59A8B.10 Aff_Y59A8A.G Y59A8B.10; 5S550; CE26206; WBGene00013347; WP:CE26206 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y70D2A.2 Aff_Y70D2.A Y70D2.A; Y70D2A.2; CE34134; WBGene00013497; WP:CE34134; XP520 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y71F9AL.6 Aff_Y71F9A_262.B Y71F9AL.6; 1D459; CE22840; WBGene00022111; WP:CE22840 Y71G12B.8 Aff_Y71G12A_203.C Y71G12B.8; 1C263; CE27030; WBGene00022148; WP:CE27030 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y71H2AM.13 Aff_Y71H2_390.F Y71H2AM.13; 3D824; CE22953; WBGene00022178; WP:CE22953 Y75B8A.26 Aff_Y75B8A.FF mrp-8; Y75B8A.26; 3N372; CE23037; NM_067197; WBGene00003414; WP:CE23037 mrp-8 encodes a predicted ATP-binding cassette (ABC) transporter that is a member of the ABCC subfamily of ABC transporters that includes the multidrug resistance-associated proteins and the cystic fibrosis transmembrane conductance regulator; by homology, MRP-8 is predicted to function as an ATP-dependent organic anion transporter that transports molecules across the plasma membrane into the extracellular space; at present, the precise role of MRP-8 in C. elegans development and/or behavior is not yet known. ABC transporters ; ABC transporter transmembrane region. Y7A9D.1 Aff_Y7A9D.1 Y7A9D.1; 4R146; CE14850; WBGene00012420; WP:CE14850 Reinke et al 2004, IVb male soma enriched genes Y87G2A.1 Aff_Y87G2A.F Y87G2A.1; 1O117; CE24681; WBGene00013593; WP:CE24681 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC262.3 Aff_ZC262.3 ZC262.3; 3J416; CE27345; CE29616; WBGene00022580; WP:CE27345; WP:CE29616 N-CAM IG domain Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC376.3 Aff_ZC376.3 ZC376.3; 5O650; CE15197; WBGene00013875; WP:CE15197 carboxylesterase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZC412.6 Aff_ZC412.6 nspa-5; ZC412.6; 5P359; CE15221; NM_074263; WBGene00013887; WP:CE15221 McElwee et al 2003 T1 targets of daf-16, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, shared sperm ZC412.7 Aff_ZC412.7 nspa-3; ZC412.7; 5P362; NM_074265; WBGene00013888 McElwee et al 2003 T1 targets of daf-16, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC434.2 Aff_ZC434.2 rps-7; ZC434.2; ZC434.2.1; ZC434.2.2; 1K907; CE06577; NM_060307; WBGene00004476; WP:CE06577 rps-7 encodes a small ribosomal subunit S7 protein. 40S ribosomal protein S7 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC434.7 Aff_ZC434.7 ZC434.7; ZC434.7.1; ZC434.7.2; 1K923; CE06582; WBGene00013893; WP:CE06582 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1058.5 Aff_ZK1058.5 ZK1058.5; 3F10; CE34138; WBGene00014205; WP:CE34138 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1127.6 Aff_ZK1127.6 ZK1127.6; ZK1127.6.1; ZK1127.6.2; 2H333; CE07644; WBGene00022853; WP:CE07644 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1236.2 Aff_ZK1236.2 cec-1; ZK1236.2; 3J517; CE00380; NM_066461; WBGene00000414; WP:CE00380 cec-1 encodes a nuclear protein with a chromodomain that is ubiquitously expressed in somatic cells, but is dispensable for embryonic survival or gross adult morphology. Nucleolin Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1307.1 Aff_ZK1307.1 ZK1307.1; ZK1307.1b.1; ZK1307.1b.2; 2J946; CE01690; CE35921; WBGene00014244; WP:CE01690; WP:CE35921 Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK185.2 Aff_ZK185.2 ZK185.2; 4F305; CE31747; WBGene00022682; WP:CE31747 ZK287.5 Aff_ZK287.5 Ce-rbx-1; rbx-1; ZK287.5; ZK287.5.1; ZK287.5.2; 5K170; CE06614; NM_073095; WBGene00004320; WP:CE06614 The rbx-1 gene encodes an ortholog of the mammalian RING box protein RBX1 (or ROC1), which interacts with several cullins and is a subunit of both the von Hippel-Lindau (VHL) tumor suppressor complex and of the SCF ubiquitin-ligase (E3) complex. Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK430.2 Aff_ZK430.2 tag-231; ZK430.2; 2E711; CE05079; WBGene00022740; WBGene00044063; WP:CE05079 ammonium transport protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK512.4 Aff_ZK512.4 ZK512.4; 3K235; CE00410; WBGene00013984; WP:CE00410 Signal Recognition Particle 9Kd protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph ZK546.14 Aff_ZK546.14 ZK546.14; ZK546.14a.1; ZK546.14a.2; ZK546.14b.1; ZK546.14b.2; 2F234; CE02914; CE33503; WBGene00022765; WP:CE02914; WP:CE33503 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Cell Structure, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK546.4 Aff_ZK546.4 ZK546.4; 2F229; CE02918; WBGene00022761; WP:CE02918 ZK593.8 Aff_ZK593.8 ZK593.8; 4L703; CE28722; WBGene00014004; WP:CE28722 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK632.10 Aff_ZK632.10 ZK632.10; 3K918; CE02385; WBGene00014017; WP:CE02385 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK637.11 Aff_ZK637.11 cdc-25.3; ZK637.11; 3K6; CE00429; NM_066571; WBGene00000388; WP:CE00429 cdc-25.3 encodes a tyrosine phosphatase that is a member of the cell division cycle 25 (CDC25) family of cell cycle regulators that includes Schizosaccharomyces pombe CDC25 and Drosophila string; cdc-25.3 is one of four cdc-25 genes in C. elegans and while it is known to be expressed in hermaphrodites, the precise function of cdc-25.3 is not yet clear; cdc-25.3 may function redundantly with cdc-25.2 during embryonic development and redundantly with cdc-25.1, cdc-25.2, and emb-29 during meiosis. CDC25/string McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK652.4 Aff_ZK652.4 rpl-35; ZK652.4; ZK652.4.1; ZK652.4.2; ZK652.4.3; ZK652.4.4; ZK652.4.5; ZK652.4.6; 3I945; CE00450; NM_066301; WBGene00004449; WP:CE00450 rpl-35 encodes a large ribosomal subunit L35 protein. 60S ribosomal protein L35 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK678.1 Aff_ZK678.1 lin-15A; ZK678.1; CE15383; WBGene00023498; WP:CE15383; XQ353 lin-15A encodes a novel, hydrophilic protein; LIN-15A activity is required non-cell autonomously to negatively regulate vulval development; genetic analysis indicates that lin-15A, a class A synMuv gene, functions upstream of the LET-23 receptor tyrosine and redundantly with class B synMuv genes, such as lin-15B and lin-35 Rb and class C synMuv genes such as trr-1 and mys-1; although the lin-15A expression pattern is not yet known, genetic mosaic analysis suggests that, in regulating vulval induction, LIN-15A functions outside of the six vulval precursor cells P(3-8).p, likely acting instead in the surrounding hypodermal tissue. LIN-15A protein ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK792.5 Aff_ZK792.5 ZK792.5; 4M450; CE03826; WBGene00014078; WP:CE03826 Pumilio-family RNA binding domains (aka PUM-HD, Pumilio homology domain) (3 domains) ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA ZK930.1 Aff_ZK930.1 ZK930.1; 2M200; CE06671; WBGene00014151; WP:CE06671 serine/threonine kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated