Baugh et al 2003, class MDE, 639 genes Gene list file name: Baugh2003_classMDE.txt Type of gene identifier: Affymetrix custom chip Description: Baugh et al 2005, Supplymental Dataset, class MDE Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations AFF_C23H3.4 Aff_C23H3.4 AFF_C25H3.3 Aff_C25H3.3 AFF_C33A11.2 Aff_C33A11.2 AFF_C35D10.1 Aff_C35D10.1 AFF_E01A2.I Aff_E01A2.I AFF_F09E5.4 Aff_F09E5.4 AFF_F21H12.1 Aff_F21H12.1 AFF_F28B3.6 Aff_F28B3.6 AFF_F44A2.6 Aff_F44A2.6 AFF_F44B9.8 Aff_F44B9.8 AFF_F49H12.D Aff_F49H12.D AFF_F53C3.9 Aff_F53C3.9 AFF_R07E5.12 Aff_R07E5.12 AFF_R11D1.9 Aff_R11D1.9 AFF_R144.3 Aff_R144.3 AFF_T08B2.9 Aff_T08B2.9 AFF_Y105E8A.L Aff_Y105E8A.L AFF_Y113G7A.I Aff_Y113G7A.I AFF_Y116A8A.LL Aff_Y116A8A.LL AFF_Y13C8_223.D Aff_Y13C8_223.D AFF_Y25C1A.A Aff_Y25C1A.A AFF_Y37D8A.21 Aff_Y37D8A.21 AFF_Y38F2A_6126.E Aff_Y38F2A_6126.E AFF_Y40H7.D Aff_Y40H7.D AFF_Y46B2_176.B Aff_Y46B2_176.B AFF_Y54E10A_159.C Aff_Y54E10A_159.C AFF_Y73F8A.X Aff_Y73F8A.X AFF_ZC395.7 Aff_ZC395.7 AFF_ZK1236.5 Aff_ZK1236.5 B0035.14 Aff_B0035.14 dnj-1; B0035.14; 4M69; CE05169; NM_069721; WBGene00001019; WP:CE05169 This gene encodes a protein containing a DnaJ ('J') domain. DNAJ protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0035.4 Aff_B0035.4 tag-317; B0035.4; B0035.4.1; B0035.4.2; B0035.4.3; 4M79; 4M81; CE05162; WBGene00007107; WP:CE05162 paramyosin like Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated B0041.3 Aff_B0041.3 B0041.3; 1F213; CE07668; WBGene00015008; WP:CE07668 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated B0205.6 Aff_B0205.6 B0205.6; 1L315; CE30405; WBGene00015021; WP:CE30405 aminotransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated B0205.8 Aff_B0205.8 B0205.8; 1L306; CE17322; WBGene00015022; WP:CE17322 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0213.3 Aff_B0213.3 nlp-28; B0213.3; 5E463; CE16774; NM_071709; WBGene00003766; WP:CE16774 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination B0238.10 Aff_B0238.10 B0238.10; 5F753; CE07700; WBGene00015074; WP:CE07700 acyltransfersase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E B0252.4 Aff_B0252.4 cyn-10; cyp-10; B0252.4; 2H202; CE02420; CE27567; NM_063015; WBGene00000886; WP:CE02420; WP:CE27567 cyp-10 encodes a divergent cyclophilin isoform that is functional when expressed in E. coli. ViswanathanM et al 2005 S2 sir-2.1 regulated B0285.4 Aff_B0285.4 B0285.4; 3F433; CE00643; WBGene00007137; WP:CE00643 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated B0303.15 Aff_B0303.15 B0303.15; 3J807; CE00004; WBGene00015133; WP:CE00004 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Ribosomal protein L11 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0303.7 Aff_B0303.7 B0303.7; 3J787; CE36521; WBGene00015128; WP:CE36521 Neutrophil oxidase factor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0334.5 Aff_B0334.5 B0334.5; 2L789; CE30122; WBGene00007145; WP:CE30122 phytoene synthase precursor ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0336.6 Aff_B0336.6 B0336.6; B0336.6.1; B0336.6.2; 3G780; CE29545; WBGene00015146; WP:CE29545 B0336.6 encodes an Abl interactor ortholog, with an SH3 domain, required for embryonic development; mammalian Abl interactors are associated with synaptosomes, growth cone particles, and macropinocytic vesicles, and may regulate Rac-dependent cytoskeletal reorganization and Abl kinase activity; B0336.6's orthologs include human SSH3BP1 (ABI1; OMIM:603050, mutated in acute myeloid leukemia), ABI-2 (OMIM:606442), and NESH (OMIM:606363); B0336.6 binds UNC-53 in two-hybrid screens. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0361.2 Aff_F56C9.4 B0361.2; 3I397; CE33549; CE38480; WBGene00015156; WP:CE33549; WP:CE38480 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0361.3 Aff_B0361.3 B0361.3; B0361.3.1; B0361.3.2; 3I373; CE34242; WBGene00015157; WP:CE34242 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0412.4 Aff_B0412.4 rps-29; B0412.4; B0412.4.1; B0412.4.2; 3B413; CE26849; NM_064862; WBGene00004498; WP:CE26849 rps-29 encodes a small ribosomal subunit S29 protein; by homology, RPS-29 is predicted to function in protein biosynthesis; in C. elegans, RPS-29 activity is broadly required for embryonic and germline development, normal body coloration and morphology, normal postembryonic growth rates, and the overall health of the animal. 40S ribosomal protein S29 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0414.8 Aff_B0414.8 B0414.8; 1G380; CE30413; CE36910; WBGene00015176; WP:CE30413; WP:CE36910 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated B0416.6 Aff_B0416.6 gly-13; B0416.6; CE26434; NM_077165; WBGene00001638; WP:CE26434; XJ912 alpha-1,3-mannosyl-glycoprotein beta-1,2-n-acetyglucosaminyltransferase ViswanathanM et al 2005 S2 sir-2.1 regulated B0491.7 Aff_B0491.7 B0491.7; 2L641; CE02109; WBGene00007194; WP:CE02109 B0491.7 encodes a putative diphthine synthase orthologous to S. cerevisiae DPH5; DPH5 is an S-adenosylmethionine:EF-2 methyltransferase required for the enzymatic conversion of 3-amino-3-carboxypropyl-histidine to diphthine; DPH5 adds at least the last two of the three methyl groups present in diphthine, and is homologous to bacterial AdoMet:uroporphyrinogen III methyltransferases. diphthine synthase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA B0495.6 Aff_B0495.6 B0495.6; 2H988; CE01764; WBGene00015205; WP:CE01764 ViswanathanM et al 2005 S2 sir-2.1 regulated B0511.12 Aff_B0511.12 B0511.12; 1L232; CE28877; WBGene00015237; WP:CE28877 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated B0547.1 Aff_B0547.1 csn-5; B0547.1; B0547.1.1; B0547.1.2; 4G415; CE06722; NM_068440; WBGene00000817; WP:CE06722 csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated B0564.1 Aff_B0564.1 tin-9.2; B0564.1; 4N865; CE20469; CE37950; NM_070119; WBGene00007201; WBGene00044083; WP:CE20469; WP:CE37950 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C01A2.4 Aff_C01A2.4 C01A2.4; 1N983; CE34247; WBGene00007216; WP:CE34247 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C01F1.2 Aff_C01F1.2 C01F1.2; 2E591; CE06743; WBGene00015297; WP:CE06743 C01F1.2 is orthologous to the human gene SCO (CYTOCHROME OXIDASE DEFICIENT, YEAST) HOMOLOG 1 (SCO1; OMIM:603644), which when mutated leads to early-onset hepatic failure; the C01F1.2 protein is predicted to be mitochondrial with 68% accuracy. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C01F6.9 Aff_C01F6.9 C01F6.9; 4J862; CE17361; NX; WBGene00007223; WP:CE17361 The C01F6.9 gene resides in an operon that also contains the genes icl-1 and lpl-1. ViswanathanM et al 2005 S2 sir-2.1 regulated C01G6.4 Aff_C01G6.4 C01G6.4; 2J562; CE00866; WBGene00007226; WP:CE00866 Zinc finger, C3HC4 type (RING finger) ViswanathanM et al 2005 S2 sir-2.1 regulated C02F12.8 Aff_C02F12.8 C02F12.8; CE03902; WBGene00015357; WP:CE03902; XE310 Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C03D6.4 Aff_C03D6.4 npp-14; C03D6.4; 1K238; CE05198; CeNup214; NM_060167; WBGene00003800; WP:CE05198 npp-14 is orthologous to the human gene NUCLEOPORIN, 214-KD (NUP214; OMIM:114350), which encodes part of the nucleopore complex mediating nucleocytoplasmic transport; NUP214, as a fusion gene with DEK (OMIM:125264), is found in a subset of acute myeloid leukemia. nucleoporin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C04F12.10 Aff_C04F12.10 Ce-face-1; fce-1; C04F12.10; 1K288; CE19683; NM_060181; WBGene00001405; WP:CE19683 fce-1 encodes an ortholog of 'farnesylated-proteins converting enzyme 1' (FACE-1), and thus probably enables post-translational processing of proteins (such as LET-60/RAS) carrying a C-terminal CaaX motif; FCE-1 protein probably accounts for the EDTA-sensitive, tosylphenylalanylchloromethane-insensitive component of CaaX-proteolytic activity in membrane extracts from C. elegans, and FCE-1 can cleave a farnesylated peptide in vitro; the S. cerevisiae homolog of FCE-1 (Ste24p) cleaves the precursor of yeast a-factor mating pheromone after its farnesylated cysteine residue, and transgenic FCE-1 rescues a mating defect of mutant yeast lacking both the Ste24p and the Rce1p CaaX-proteases. Zinc-binding metalloprotease domain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C04F5.9 Aff_C04F5.9 C04F5.9; 5F594; CE19673; WBGene00015451; WP:CE19673 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C04F6.5 Aff_C04F6.5 dhs-27; C04F6.5; CE37079; NM_076190; WBGene00000990; WP:CE37079; XE32 dhs-27 encodes a short-chain dehydrogenase predicted to be mitochondrial. alcohol/ribitol dehydrogenase ViswanathanM et al 2005 S2 daf-16 Resveratrol C05D11.12 Aff_C05D11.12 let-721; C05D11.12; C05D11.12.1; C05D11.12.2; 3H534; CE29662; NM_066014; WBGene00002855; WP:CE29662 The let-721 gene encodes an ortholog of the human gene SIMILAR TO ELECTRON-TRANSFERRING-FLAVOPROTEIN DEHYDROGENASE (ETFDH), which when mutated leads to glutaricaciduria type IIC (OMIM:231675). YAAS McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Oxidation, ViswanathanM et al 2005 S2 sir-2.1 regulated C05D11.9 Aff_C05D11.9 C05D11.9; 3H518; CE24787; WBGene00015486; WP:CE24787 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated C05D9.7 Aff_C05D9.7 C05D9.7; CE07933; WBGene00015474; WP:CE07933; XB736 C06A5.11 Aff_C06A5.3 sir-2.4; C06A5.11; 1G567; CE27656; NM_059332; WBGene00004803; WP:CE27656 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C06G3.10 Aff_C06G3.10 cgo-2; cogc-2; C06G3.10; 4H802; CE28817; CELDLC; NM_068691; WBGene00000585; WP:CE28817; cog2 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C06G3.11 Aff_C06G3.11 tin-9.1; C06G3.11; C06G3.11b.1; C06G3.11b.2; 4H808; CE07987; CE33518; WBGene00006572; WP:CE07987; WP:CE33518; tim9a; tim9b tin-9 encodes a member of the Tim10/DDP family of zinc finger proteins, a family of proteins typically involved in mitochondrial protein import, and localized to the mitochondrial intermembrane space. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C07G1.5 Aff_C07G1.5 hgrs-1; pqn-9; C07G1.5; 4I966; CE32574; NM_068974; WBGene00004101; WP:CE32574 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C07H4.2 Aff_C07H4.2 clh-5; C07H4.2; C07H4.2.1; C07H4.2.2; 2J386; CE27360; NM_063539; WBGene00000532; WP:CE27360 The clh-5 gene encodes a chloride channel, whose human homologs include CLC1 and CLCN5; the latter homolog is imvolved in receptor-mediated endocytosis. chloride channel protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C07H6.1 Aff_C07H6.1 lig-4; C07H6.1; 3I613; CE34522; NM_066252; WBGene00002986; WP:CE34522 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C07H6.2 Aff_C07H6.2 C07H6.2; 3I609; CE00756; WBGene00015579; WP:CE00756 ViswanathanM et al 2005 S2 sir-2.1 regulated C08B11.7 Aff_C08B11.7 ubh-4; C08B11.7; 2I328; CE36913; NM_063283; WBGene00006724; WP:CE36913 thiolesterase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C08B11.8 Aff_C08B11.8 C08B11.8; 2I333; CE01478; WBGene00007435; WP:CE01478 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C08F8.1 Aff_C08F8.1 C08F8.1; 4L915; CE05248; WBGene00007443; WP:CE05248 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C08H9.3 Aff_C08H9.3 C08H9.3; 2K174; CE36914; CE37608; WBGene00007464; WP:CE36914; WP:CE37608 glucosyltransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C09G5.2 Aff_C09G5.2 C09G5.2; 2K992; CE15608; WBGene00007488; WP:CE15608 C09G5.2 encodes an ortholog of S. cerevisiae DPH2/YKL191W and human DPH2L2 (OMIM:603456); C09G5.2 is a putative protein component of diphtamide synthesis; C09G5.2 has no obvious function in mass RNAi assays. Diphthamide biosynthesis protein (diptheria resistance protein) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C C10F3.5 Aff_C10F3.5 pcm-1; C10F3.5; 5G442; CE08070; NM_072150; WBGene00003954; WP:CE08070 L-isoaspartyl/D-aspartyl methyltransferase ViswanathanM et al 2005 S2 sir-2.1 regulated C13B9.3 Aff_C13B9.3 phi-30; C13B9.3; 3H712; CE01778; WBGene00015734; WP:CE01778 C13B9.3 encodes a delta subunit of the coatomer (COPI) complex; in mass RNAi assays, C13B9.3 is required for fertility and general health. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C14A11.6 Aff_C14A11.6 C14A11.6; CE08154; WBGene00015751; WP:CE08154; XD426 C14A4.3 Aff_C14A4.3 C14A4.3; CE32796; NM_063881; WBGene00007556; WP:CE32796 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Metabolism, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C14A4.5 Aff_C14A4.5 crn-5; C14A4.5; 2K883; CE02146; NM_063883; WBGene00000798; WP:CE02146 Prokaryotic ribonuclease PH McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C14C10.4 Aff_C14C10.4 C14C10.4; C14C10.4.1; C14C10.4.2; 5N74; CE05283; WBGene00007587; WP:CE05283 Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C14C11.7 Aff_C14C11.7 C14C11.7; 5G146; CE06826; WBGene00015769; WP:CE06826 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C15F1.6 Aff_C15F1.C art-1; C15F1.6; 2H262; CE20509; NM_063029; WBGene00000198; WP:CE20509 a protein similar to synaptic glycoprotein SC2 from mammals. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C15H11.4 Aff_C15H11.4 dhs-22; C15H11.4; 5O900; CE08181; NM_074169; WBGene00000985; WP:CE08181 dhs-22 encodes a short-chain dehydrogenase predicted to be mitochondrial. dehydrogenase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C15H11.8 Aff_C15H11.8 C15H11.8; 5O904; CE08185; WBGene00007616; WP:CE08185 DNA-directed RNA polymerase I like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated C16A3.2 Aff_C16A3.2 C16A3.2; 3H479; CE08188; WBGene00015807; WP:CE08188 protein-tyrosine phosphatase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C16A3.5 Aff_C16A3.5 C16A3.5; C16A3.5.1; C16A3.5.2; 3H471; CE04005; WBGene00015810; WP:CE04005 NADH-ubiquinone oxidoreductase B22 Lund et al 2002 Fig1 aging-regulated genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C16C10.5 Aff_C16C10.5 C16C10.5; 3F260; CE01496; WBGene00007626; WP:CE01496 Glutaredoxin, Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan C17C3.1 Aff_C17C3.1 C17C3.1; 2F863; CE27070; CE27071; CE27072; CE27073; CE39676; WBGene00015887; WP:CE27070; WP:CE27071; WP:CE27072; WP:CE27073; WP:CE39676 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C17G1.4 Aff_C17G1.4 C17G1.4; CE08283; CE37318; WBGene00007651; WP:CE08283; WP:CE37318; XK546 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories C17G10.1 Aff_C17G10.1 C17G10.1; C17G10.1.1; C17G10.1.2; 2F887; CE01785; WBGene00015915; WP:CE01785 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C17G10.2 Aff_C17G10.2 C17G10.2; 2F885; CE29583; WBGene00015916; WP:CE29583 TPR domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C17G10.8 Aff_C17G10.8 dhs-6; C17G10.8; CED6.1; 2F906; CE02490; WBGene00000970; WP:CE02490 The dhs-6 locus is predicted to encode four transcripts derived from alternative splicing and alternative transcriptional initiation sites; the longest transcript is predicted to encode a member of the eukaryotic translation initiation factor family within its amino-terminal end, and is a member of both the SCP-2 sterol transfer family and short-chain dehydrogenase-reductase families within its carboxyl-terminal end; DHS-6 is predicted to be mitochondrial. Alcohol dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C18A3.2 Aff_C18A3.2 C18A3.2; 2G9; CE27707; WBGene00015940; WP:CE27707 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C18B2.4 Aff_C18B2.4 C18B2.4; CE04043; WBGene00015955; WP:CE04043; XE224 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C18E9.6 Aff_C18E9.6 C18E9.6; 2J262; CE05298; WBGene00007686; WP:CE05298 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C24D10.4 Aff_C24D10.4 C24D10.4; 4F925; CE16876; WBGene00016055; WP:CE16876 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C24D10.6 Aff_C24D10.6 C24D10.6; 4F924; CE16878; WBGene00016057; WP:CE16878 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C24F3.2 Aff_C24F3.2 C24F3.2; 4K987; CE18519; WBGene00007697; WP:CE18519 Dual specificity phosphatase, catalytic domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C24F3.4 Aff_C24F3.4 C24F3.4; 4K980; CE18521; WBGene00007698; WP:CE18521 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 C25A1.13 Aff_C25A1.13 C25A1.13; 1K769; CE08379; WBGene00007712; WP:CE08379 NADH-ubiquinone oxidoreductase B8 subunit McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C26B2.1 Aff_C26B2.1 C26B2.1; 4I784; CE04087; WBGene00016124; WP:CE04087 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol C26E6.6 Aff_C26E6.6 C26E6.6; C26E6.6.1; C26E6.6.2; 3G25; CE39477; WBGene00016142; WP:CE39477 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Ribosomal protein L3 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C27A12.9 Aff_C27A12.9 C27A12.9; 1G638; CE36272; WBGene00016159; WP:CE36272 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 C27F2.8 Aff_C27F2.8 C27F2.8; 3G82; CE39000; WBGene00016170; WP:CE39000 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C27H6.4 Aff_C27H6.4 C27H6.4; 5K464; CE08428; CE31322; WBGene00007786; WP:CE08428; WP:CE31322 C28H8.12 Aff_C28H8.12 dnc-2; C28H8.12; 3H14; CE01823; NM_065885; WBGene00001018; WP:CE01823 dnc-2 encodes a member of the dynamitin family that affects spindle alignment in polarized cells in early embryos, nuclear movement, spindle morphology, chromosome segregation, and pronuclear migration. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C30B5.2 Aff_C30B5.2 C30B5.2; 2G487; CE31889; CE31890; WBGene00016244; WP:CE31889; WP:CE31890 ViswanathanM et al 2005 S2 sir-2.1 regulated C30C11.1 Aff_C30C11.1 C30C11.1; 3J539; CE00100; WBGene00016249; WP:CE00100 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C30H6.8 Aff_C30H6.8 C30H6.8; 4S327; CE15652; WBGene00007825; WP:CE15652 Thioredoxins ViswanathanM et al 2005 S2 sir-2.1 regulated C33H5.15 Aff_C33H5.15 sgo-1; C33H5.15; 4I560; CE34732; NM_068889; WBGene00016381; WP:CE34732 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C33H5.7 Aff_C33H5.7 C33H5.7; 4I539; CE04150; WBGene00016374; WP:CE04150 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C34B2.10 Aff_C34B2.10 phi-56; C34B2.10; C34B2.10.1; C34B2.10.2; 1L258; CE16898; WBGene00016395; WP:CE16898 ViswanathanM et al 2005 S2 sir-2.1 regulated C34B2.2 Aff_C34B2.2 kbp-5; C34B2.2; 1L263; CE16890; NM_060399; WBGene00016387; WP:CE16890 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C34D4.13 Aff_C34D4.13 C34D4.13; 4H896; CE34735; WBGene00016404; WP:CE34735 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C34E10.8 Aff_C34E10.8 C34E10.8; 3G340; CE32158; WBGene00016409; WP:CE32158 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen C34G6.7 Aff_C34G6.7 pqn-19; C34G6.7; C34G6.7a.1; C34G6.7a.2; C34G6.7b.1; C34G6.7b.2; 1G480; CE29700; CE32816; NM_059309; NM_182013; WBGene00004109; WP:CE29700; WP:CE32816 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C35B8.3 Aff_C35B8.3 C35B8.3; C35B8.3a.1; C35B8.3a.2; CE02536; CE27827; WBGene00016438; WP:CE02536; WP:CE27827; XJ835 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol C35D10.10 Aff_C35D10.10 C35D10.10; 3F950; CE01191; WBGene00016446; WP:CE01191 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C35D10.9 Aff_C35D10.9 ced-4; C35D10.9; 3F943; CE01203; CE38154; WBGene00000418; WP:CE01203; WP:CE38154 ced-4 encodes a novel protein; along with CED-3, CED-4 is required for the initiation of programmed cell death; accordingly, genetic analyses indicate that ced-3 and ced-4 function upstream of ced-1, ced-2, and nuc-1 in the programmed cell death pathway; in yeast two-hybrid experiments, and upon coexpression in mammalian cells, CED-4 interacts with CED-9, an anti-apoptotic BCL-2 homolog; coexpression of CED-4 and CED-9 results in redistribution of CED-4 from the cytosol to organellar membranes, suggesting that CED-9 may negatively regulate CED-4 activity by sequestering CED-4 to intracellular membranes. Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C38D4.6 Aff_C38D4.6 ceh-3; nob-2; pal-1; C38D4.6; C38D4.6a.1; C38D4.6a.2; C38D4.6b.1; C38D4.6b.2; 3F896; CE05383; CE27837; NM_065590; WBGene00003912; WP:CE05383; WP:CE27837 pal-1 encodes a homeodomain protein that is the C. elegans Caudal ortholog; PAL-1 is required maternally and embryonically for cell fate specification and posterior patterning during embryogenesis; PAL-1 is also required postembryonically for fate specification of the posterior V6 neuroectoblast during male tail development; PAL-1 is expressed in posterior blastomeres beginning at the four-cell stage of embryogenesis and its expression continues during embryogenesis in posterior-derived tissues and cells undergoing movement or forming midline structures; pal-1 is subject to both transcriptional and translational regulation. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E C40H1.6 Aff_C40H1.6 C40H1.6; 3K421; CE00114; WBGene00008041; WP:CE00114 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Roy et al 2002 S3 muscle genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C42C1.11 Aff_C42C1.11 AP-1; C42C1.11; C42C1.11a.1; C42C1.11a.2; C42C1.11c.1; C42C1.11c.2; 4N45; CE24840; CE33564; CE33565; WBGene00016589; WP:CE24840; WP:CE33564; WP:CE33565 peptidase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C42C1.16 Aff_C42C1.10 C42C1.16; 4N49; CE29223; WBGene00016593; WP:CE29223 C42C1.5 Aff_C42C1.5 tag-335; C42C1.5; 4N40; CE16911; WBGene00016583; WP:CE16911 guanyltransferase Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C43E11.7 Aff_C43E11.7 ndx-7; C43E11.7; 1E808; CE30504; NM_058935; WBGene00003584; WP:CE30504 ndx-7 encodes a NUDIX hydrolase; by sequence comparison, NDX-7 is predicted to function as a pyrophosphatase, and is most closely related to the mouse RP2 protein that has unknown substrate specificity but is regulated transcriptionally by the presence of androgens; in C. elegans, loss of ndx-7 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, consistent with the proposed nonessential roles for Nudix proteins in eliminating potentially toxic nucleotide metabolites from cells and modulating levels of metabolic intermediates by shuttling them into alternative biochemical pathways. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C43E11.8 Aff_C43E11.8 C43E11.8; 1E812; CE08686; WBGene00016606; WP:CE08686 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C44B9.3 Aff_C44B9.3 C44B9.3; 3L966; CE05405; WBGene00008080; WP:CE05405 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C44C1.2 Aff_C44C1.2 C44C1.2; CE30126; WBGene00016642; WP:CE30126; XB577 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B C44H4.7 Aff_C44H4.7 eor-2; C44H4.7; CE31445; CE31446; WBGene00001325; WP:CE31445; WP:CE31446; XP225 eor-2 encodes an unfamiliar protein, similar to CG17233 in Drosophila and KIAA1205 in H. sapiens, required for signal transduction by both RAS and Wnt pathways in both excretory system development and P12 fate specification. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C45B11.1 Aff_C45B11.1 pak-4; tag-66; C45B11.1; 5L518; CE05425; CE20564; WBGene00006443; WP:CE05425; WP:CE20564 P21-Rho-binding domain ; Eukaryotic protein kinase domain Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C46H3.2 Aff_C46H3.2 C46H3.2; C46H3.2b.1; C46H3.2b.2; CE29228; CE33921; WBGene00016725; WP:CE29228; WP:CE33921; XB832 tyrosine-protein kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C47B2.2 Aff_C47B2.2 C47B2.2; C47B2.2b.1; C47B2.2b.2; CE17562; CE23599; WBGene00008131; WP:CE17562; WP:CE23599 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C47E12.4 Aff_C47E12.4 pyp-1; C47E12.4; C47E12.4c.1; C47E12.4c.2; C47E12.4c.3; C47E12.4d.1; C47E12.4d.2; C47E12.4d.3; 4K760; CE05448; CE33767; CE33768; CE33769; WBGene00008149; WP:CE05448; WP:CE33767; WP:CE33768; WP:CE33769 inorganic pyrophosphatase Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C48E7.3 Aff_C48E7.3 lpd-2; C48E7.3; 1G831; CE29953; NM_059405; WBGene00003059; WP:CE29953 lpd-2 encodes a predicted transcription factor with homology to transcription factors of the CCAAT/Enhancer Binding Protein family (C/EBPA and B, OMIM:116897, 189965, associated with the regulation of mammalian adipocyte differentiation); in C. elegans, LPD-2 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for larval development; in addition, LPD-2 may be part of a conserved pathway regulating lipogenesis, as LPD-2 appears to positively regulate expression of sbp-1, which encodes the C. elegans Sterol Regulatory Element Binding Protein (SREBP) homolog, a basic helix-loop-helix-type transcription factor also required for normal lipid metabolism and larval development. Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b TF, ViswanathanM et al 2005 S2 sir-2.1 regulated C49C3.15 Aff_C49C3.15 C49C3.15; 4S279; CE37493; WBGene00008204; WP:CE37493 C50F4.16 Aff_C50F4.11 C50F4.16; C50F4.16.1; C50F4.16.2; 5K18; CE28213; WBGene00008238; WP:CE28213 The C50F4.16 gene encodes a NUDIX hydrolase. C50F7.4 Aff_C50F7.4 C50F7.4; 4I495; CE04242; SCB2; WBGene00016844; WP:CE04242 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. succinyl-CoA synthetase beta chain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C52E4.2 Aff_C52E4.2 mif-2; C52E4.2; C52E4.2.1; C52E4.2.2; 5M458; CE08944; NM_073602; WBGene00003235; WP:CE08944 macrophage migration inhibitory factor like protein ViswanathanM et al 2005 S2 sir-2.1 regulated C56A3.6 Aff_C56A3.6 C56A3.6; 5O34; CE32339; WBGene00008345; WP:CE32339 EF hand (2 domains) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C56C10.10 Aff_C56C10.10 C56C10.10; 2G884; CE02564; WBGene00016966; WP:CE02564 TPR domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C56C10.3 Aff_C56C10.3 phi-27; tag-309; C56C10.3; C56C10.3.1; C56C10.3.2; 2G881; CE02568; WBGene00016961; WP:CE02568 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated CD4.3 Aff_CD4.3 CD4.3; CD4.3.1; CD4.3.2; 5G73; CE16951; WBGene00016989; WP:CE16951 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated CD4.4 Aff_CD4.4 CD4.4; 5G71; CE16952; WBGene00016990; WP:CE16952 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated D1007.5 Aff_D1007.5 D1007.5; D1007.5a.1; D1007.5a.2; D1007.5b.1; D1007.5b.2; 1F150; CE29034; CE33577; WBGene00017003; WP:CE29034; WP:CE33577 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated D1022.1 Aff_D1022.1 ubc-6; D1022.1; 2H771; CE29241; CE39712; NM_063165; WBGene00006703; WP:CE29241; WP:CE39712 Ubiquitin-conjugating enzyme Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol D2013.10 Aff_D2013.10 tag-175; D2013.10; 2J613; CE17622; WBGene00006520; WBGene00008406; WP:CE17622 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph D2013.6 Aff_D2013.6 D2013.6; 2J621; CE00931; WBGene00008404; WP:CE00931 ViswanathanM et al 2005 S2 sir-2.1 regulated D2023.4 Aff_D2023.4 D2023.4; D2023.4.1; D2023.4.2; 5M304; CE09074; WBGene00008408; WP:CE09074 D2023.4 encodes a thialysine N-(epsilon)-acetyltransferase, belonging to the GCN5-related N-acetyltransferase superfamily; recombinant D2023.4 protein forms a catalytically active homodimer, most efficiently catalysing the N-acetylation of thialysine [S-(2-aminoethyl)-L-cysteine], O-(2-aminoethyl)-L-serine and S-(2-aminoethyl)-D,L-homocysteine. diamine acetyltransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 D2023.5 Aff_D2023.5 D2023.5; 5M306; CE09075; WBGene00008409; WP:CE09075 thiosulphate sulphurtransferase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA D2024.6 Aff_D2024.6 cap-1; D2024.6; D2024.6.1; D2024.6.2; 4H994; CAPZ/A; CE04295; NM_068744; WBGene00000292; WP:CE04295 cap-1 encodes an F-actin capping protein alpha subunit that affects fertility; likely expressed in touch receptor neurons. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated D2030.5 Aff_D2030.5 mce-1; D2030.5; 1I159; CE09082; WBGene00008415; WP:CE09082 B.subtilis YQJC protein like ViswanathanM et al 2005 S2 sir-2.1 regulated D2030.8 Aff_D2030.8 D2030.8; 1I169; CE28545; WBGene00008418; WP:CE28545 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated D2089.3 Aff_D2089.3 D2089.3; 2K952; CE00938; WBGene00008434; WP:CE00938 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph D2096.2 Aff_D2096.2 D2096.2; 4J145; CE29245; CE38496; WBGene00017070; WP:CE29245; WP:CE38496 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated DY3.1 Aff_DY3.1 tim-13; tin-13; DY3.1; 1J336; CE15745; NM_059969; WBGene00006574; WP:CE15745; tim13 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol E01G6.1 Aff_E01G6.1 E01G6.1; CE03112; WBGene00008449; WP:CE03112; XM883 pancreatic trypsin inhibitor (kunitz) protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 E02H1.2 Aff_E02H1.2 E02H1.2; 2J878; CE01537; WBGene00008456; WP:CE01537 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. GTP binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA EEED8.10 Aff_EEED8.10 EEED8.10; 2F686; CE39344; WBGene00017138; WP:CE39344 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Probable RNA binding protein. Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F01F1.15 Aff_F01F1.11 F01F1.15; F01F1.15.1; F01F1.15.2; 3G958; CE26884; WBGene00017169; WP:CE26884 F01F1.2 Aff_F01F1.2 F01F1.2; 3G969; CE26886; WBGene00017159; WP:CE26886 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F01F1.8 Aff_F01F1.8 cct-6; F01F1.8; F01F1.8a.1; F01F1.8a.2; F01F1.8b.1; F01F1.8b.2; F01F1.8b.3; 3G944; CE01234; CE30647; NM_171135; NM_171136; WBGene00000381; WP:CE01234; WP:CE30647 eukaryotic cytosolic chaperonin; affects viability and fertility, and is expressed in various muscle and neuronal cells: near the pharynx, near the anal sphincter, in the ventral nerve cord and the nerve ring; occasionally the expression is visible in hypodermal cells and in some vulval cells. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F01G10.1 Aff_F01G10.1 F01G10.1; F01G10.1.1; F01G10.1.2; 4L9; CE09163; WBGene00008506; WP:CE09163 The F01G10.1 gene encodes an ortholog of the human gene TRANSKETOLASE (TKT; OMIM:606781), which when mutated leads to Wernicke-Korsakoff syndrome (OMIM:277730). transketolase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F02E8.3 Aff_F02E8.3 aps-2; F02E8.3; CE07018; NM_076366; WBGene00000157; WP:CE07018; XF77 The aps-2 gene encodes an adaptin: specifically, it encodes an ortholog of the sigma2 subunit of adaptor protein complex 2 (AP-2), which mediates endocytosis from the plasma membrane; APS-2 appears to be required for embryonic and larval development and for normal body morphology, but is not required for endocytosis of yolk protein in developing oocytes; APS-2 is expressed in nearly all cells during embryogenesis, but during larval and adult stages, expression is confined to neurons and some hypodermal cells, including vulval hypodermal cells during the fourth larval stage. Clathrin coat assembly protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F02E9.1 Aff_F02E9.1 F02E9.1; 1I981; CE09183; WBGene00008528; WP:CE09183 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F02E9.4 Aff_F02E9.4 pqn-28; F02E9.4; 1I999; CE33046; NM_059883; WBGene00004117; WP:CE33046 pqn-28 encodes an ortholog of the SIN3 family of histone deacetylase subunits, which also has a glutamine/asparagine-rich domain, possibly involved in epigenetic regulation; pqn-28 has no obvious phenotype in mass RNAi screens; on the basis of its homology, PQN-28, when activated by promoter-specific transcription factors, is expected to work in conjunction with other histone deacetylase components to induce chromatin silencing; PQN-28 may also silence genes by colocating to them with the O-GlcNAc transferase homolog OGT-1. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F02E9.5 Aff_F02E9.5 F02E9.5; 1J2; CE23628; WBGene00008530; WP:CE23628 Jones et al 2001 Dauer specific genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F02E9.7 Aff_F02E9.7 F02E9.7; 1I991; CE09190; WBGene00008531; WP:CE09190 acid phosphatase Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F07A11.2 Aff_F07A11.2 F07A11.2; F07A11.2b.1; F07A11.2b.2; F07A11.2b.3; 2L884; CE03144; CE27915; WBGene00008546; WP:CE03144; WP:CE27915 glucosamine-fructose-6-phosphate aminotransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, IVb male soma enriched genes F08B6.2 Aff_F08B6.E gpc-2; F08B6.2; F08B6.2.1; F08B6.2.2; F08B6.2.3; 1H335; CE20656; NM_059534; WBGene00001682; WP:CE20656 gpc-2 encodes one of two C. elegans heterotrimeric G protein gamma subunits; gpc-2 is required, along with its partner GPB-1, a G protein beta subunit, for proper mitotic spindle positioning and orientation during early embryonic cell divisions; to date, GPC-2 expression has been reported in electrically excitable cells (all neurons and muscles). ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08F1.7 Aff_F08F1.7 tag-123; F08F1.7; CE09254; WBGene00006472; WP:CE09254; XJ38 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated F08F8.2 Aff_F08F8.2 F08F8.2; 3I451; CE30649; WBGene00017268; WP:CE30649 Hydroxymethylglutaryl-coA reductase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F08G12.3 Aff_F08G12.3 F08G12.3; CE03168; WBGene00008587; WP:CE03168; XL921 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma F08G2.4 Aff_F08G2.4 F08G2.4; 2O121; 2O123; CE19776; WBGene00008576; WP:CE19776 Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F09E5.13 Aff_F09E5.13 agt-2; cAGT-2; F09E5.13; 2F660; CE02608; NM_062607; WBGene00000094; WP:CE02608 agt-2 encodes a paralog of the DNA repair enzyme O6-Alkylguanine DNA-alkyltransferase (AGT); AGT-2 has AGT biochemical activity and is expressed at all developmental stages. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F09E5.3 Aff_F09E5.3 F09E5.3; F09E5.3.1; F09E5.3.2; 2F665; CE02610; WBGene00017283; WP:CE02610 Deoxyribose-phosphate aldolase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F09E5.5 Aff_F09E5.5 F09E5.5; F09E5.5.1; F09E5.5.2; 2F661; CE29752; WBGene00017284; WP:CE29752 Reinke et al 2004, wt herm vs wt male enriched gen F09E5.8 Aff_F09E5.8 F09E5.8; 2F641; CE02615; WBGene00017286; WP:CE02615 Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F09F7.4 Aff_F09F7.4 F09F7.4; F09F7.4a.1; F09F7.4a.2; F09F7.4b.1; F09F7.4b.2; F09F7.4b.3; 3G645; CE00689; CE30654; WBGene00017301; WP:CE00689; WP:CE30654 Enoyl-CoA hydratase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F10B5.2 Aff_F10B5.2 F10B5.2; 2I437; CE01544; WBGene00008639; WP:CE01544 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Unkown F10C2.2 Aff_F10C2.2 kup-1; F10C2.2; 5M514; CE09306; NM_073615; WBGene00002241; WP:CE09306; kup1 kup-1 encodes a novel protein that is conserved in C. briggsae, but contains no other known homologs; kup-1 is the upstream gene in an operon with pkc-1, which encodes two protein kinase C isoforms of the nPKC isotype; the polycistronic kup-1/pkc-1 mRNA is detected at low levels in embryos and larvae, but its expression greatly increases in adults; as loss of kup-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kup-1 in C. elegans development and/or behavior is not yet known. KUP-1 protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F10C2.4 Aff_F10C2.4 F10C2.4; 5M525; CE09308; WBGene00008645; WP:CE09308 F10C2.4 encodes a homolog of the DNA polymerase delta complex subunit A that is required in embryos for the normal timing of embryonic cell divisions (much as DIV-1 is) and, also, for normal chromosome segregation (probably because of defective DNA replication). DNA polymerase family B McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F10C2.6 Aff_F10C2.6 drs-2; F10C2.6; 5M531; CE31906; NM_073618; WBGene00001095; WP:CE31906 drs-2 encodes a putative aspartyl-tRNA synthetase. aspartyl-tRNA synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F10D11.2 Aff_F10D11.2 F10D11.2; 1J12; CE32366; WBGene00008648; WP:CE32366 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F10E7.6 Aff_F10E7.6 F10E7.6; 2H405; CE04361; WBGene00017348; WP:CE04361 F10G7.3 Aff_F10G7.3 asf-1; F10G7.3; F10G7.3.1; F10G7.3.2; 2E993; CE39722; WBGene00017368; WP:CE39722 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F11G11.7 Aff_F11G11.7 dnj-9; F11G11.7; 2F149; CE07060; NM_062471; WBGene00001027; WP:CE07060 This gene encodes a protein containing a DnaJ ('J') domain. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F12F6.6 Aff_F12F6.6 sec-24.1; F12F6.6; 4M328; CE05594; NM_069777; WBGene00004755; WP:CE05594 sec-24.1 encodes one of two C. elegans Sec24 homologs; in Saccharomyces cerevisiae, Sec24 is a member of the Sec24-Sec23 subunit of the COPII coat complex, assembly of which is essential for the first step of secretory protein transport from the endoplasmic reticulum (ER) to the Golgi; by homology with Sec24, SEC-24.1 is predicted to facilitate vesicle cargo selection, and likely contains multiple, independent sites for binding to secreted proteins; loss of sec-24.1 activity via RNAi indicates that SEC-24.1 is required for cuticle secretion and oogenesis. Yeast hypothetical YIK9 protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F13D12.2 Aff_F13D12.2 ldh-1; F13D12.2; 2M15; CE02181; LDH; NM_064102; WBGene00002262; WP:CE02181 ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency. L-lactate dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F13G3.11 Aff_F13G3.7 F13G3.11; F13G3.11.1; F13G3.11.2; 1H885; CE28913; WBGene00008769; WP:CE28913 F13G3.4 Aff_F13G3.4 dylt-1; F13G3.4; 1H876; CE17659; NM_059662; WBGene00008764; WP:CE17659 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated F13G3.9 Aff_F13G3.9 mif-3; F13G3.9; 1H890; CE09371; NM_059668; WBGene00003236; WP:CE09371 macrophage migratory inhibitory factor MIF like Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F13H10.4 Aff_F13H10.4 F13H10.4; 4L782; CE05625; WBGene00008775; WP:CE05625 F13H10.4 is orthologous to the human gene A-GLUCOSIDASE I (GCS1; OMIM:601336), which when mutated leads to disease. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F17A9.2 Aff_F17A9.2 F17A9.2; 5G593; CE19798; WBGene00017534; WP:CE19798 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F17C11.7 Aff_F17C11.7 F17C11.7; 5L438; CE05654; CE37354; WBGene00008918; WP:CE05654; WP:CE37354 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F17H10.1 Aff_F17H10.1 F17H10.1; CE03226; WBGene00008925; WP:CE03226; XN725 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F18A1.2 Aff_F18A1.2 lin-26; F18A1.2; F18A1.2.1; F18A1.2.2; F18A1.2.3; 2H973; CE27972; WBGene00003012; WP:CE27972 lin-26 encodes a putative C2H2 zinc finger-containing protein required for proper differentiation of ectodermal and mesodermal epithelial cells; LIN-26 is expressed in many different cell types including the rectal rep cells, the somatic gonad, glial cells, and hypodermal cells; ectopic LIN-26 expression during embryogenesis induces epithelial-like cell fates suggesting that LIN-26 is sufficient for epithelial differentiation. transcription factor Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F20B6.2 Aff_F20B6.2 vha-12; F20B6.2; F20B6.2.1; F20B6.2.2; CE04424; NM_076310; WBGene00006921; WP:CE04424; XE811 vacuolar ATP synthase (strong) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F20D1.3 Aff_F20D1.3 F20D1.3; F20D1.3.1; F20D1.3.2; CE31486; WBGene00008975; WP:CE31486; XP595 F20D1.4 Aff_F20D1.4 F20D1.4; CE09497; WBGene00008976; WP:CE09497; XP602 transcriptional activator protein PUR-alpha like Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F21D5.8 Aff_F21D5.8 F21D5.8; 4J504; CE03250; WBGene00009013; WP:CE03250 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F21G4.2 Aff_F21G4.2 mrp-4; F21G4.2; CE09548; NM_077257; WBGene00003410; WP:CE09548; XK507 The mrp-4 gene encodes a homolog of human CFTR, which when mutated leads to cystic fibrosis (OMIM:219700). multidrug resistance-associated protein Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F22F7.1 Aff_F22F7.1 F22F7.1; F22F7.1a.1; F22F7.1a.2; 5C603; CE17691; CE32871; WBGene00017719; WP:CE17691; WP:CE32871 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F23B12.6 Aff_F23B12.6 tag-114; F23B12.6; F23B12.6.1; F23B12.6.2; 5O929; CE09598; WBGene00006465; WBGene00009083; WP:CE09598 protein farnesyltransferase beta subunit McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F23C8.4 Aff_F23C8.K ubxn-1; F23C8.4; F23C8.K; 1D3; CE20713; WBGene00017733; WP:CE20713 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F25B4.1 Aff_F25B4.1 F25B4.1; F25B4.1.1; F25B4.1.2; 5G193; CE09620; WBGene00017765; WP:CE09620 F25B4.1 is orthologous to the human gene GLYCINE CLEAVAGE SYSTEM T-PROTEIN (AMT; OMIM:238310), which when mutated leads to glycine encephalopathy. aminomethytransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 F25B4.4 Aff_F25B4.4 F25B4.4; 5G165; CE09622; WBGene00017767; WP:CE09622 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F25G6.8 Aff_F25G6.8 F25G6.8; F25G6.8.1; F25G6.8.2; 5J44; CE09644; WBGene00017799; WP:CE09644 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F25H2.13 Aff_F25H2.13 F25H2.13; 1L153; CE15894; WBGene00009124; WP:CE15894 DEAH-type helicase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol F25H5.6 Aff_F25H5.6 F25H5.6; F25H5.6.1; F25H5.6.2; 1J734; CE29591; WBGene00009128; WP:CE29591 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F25H8.1 Aff_F25H8.1 F25H8.1; 4K696; CE05727; WBGene00009131; WP:CE05727 Yeast protein 00926 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F25H9.6 Aff_F25H9.6 F25H9.6; 5N948; CE09663; WBGene00009138; WP:CE09663 Yeast hypothetical 65.2 KD protein like McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F26A1.1 Aff_F26A1.1 F26A1.1; 3F941; CE27757; WBGene00017801; WP:CE27757 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F26B1.2 Aff_F26B1.2 F26B1.2; F26B1.2c.1; F26B1.2c.2; F26B1.2c.3; 1G895; CE09674; CE33057; CE33058; CE33059; CE33060; WBGene00017816; WP:CE09674; WP:CE33057; WP:CE33058; WP:CE33059; WP:CE33060 RNA-binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F26D10.3 Aff_F26D10.3 hsp-1; F26D10.3; F26D10.3.1; F26D10.3.2; F26D10.3.3; T28F3.2; 4S223; CE09682; NM_070667; WBGene00002005; WP:CE09682 hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity. HSP-1 heat shock 70kd protein A Custodia et al 2001 T2 heat shock, Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated F26F4.3 Aff_F26F4.3 rom-1; F26F4.3; 3F995; CE32392; NM_065628; WBGene00004400; WP:CE32392 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F26F4.4 Aff_F26F4.4 tag-340; F26F4.4; F26F4.4.1; F26F4.4.2; F26F4.4.3; 3F991; CE30767; WBGene00017826; WP:CE30767 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F26H9.6 Aff_F26H9.6 CE-RAB5; rab-5; F26H9.6; F26H9.6.1; F26H9.6.2; 1J885; CE09711; NM_060080; WBGene00004268; WP:CE09711 rab-5 encodes a rab related protein of the Ras GTPase superfamily that affects both the localization of P-granules and of PAR-2, and also affects embryonic and larval viability and the cytoplasmic appearance of cells in the early embryo. RAS-related protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories F27D4.2 Aff_F27D4.2 F27D4.2; F27D4.2.1; F27D4.2.2; F27D4.2.3; F27D4.2.4; 1I282; CE36140; WBGene00009188; WP:CE36140 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F27D4.5 Aff_F27D4.5 tag-173; F27D4.5; F27D4.5.1; F27D4.5.2; 1I305; CE05736; WBGene00006518; WP:CE05736 tag-173/F27D4.5 is orthologous to the human gene BRANCHED CHAIN KETO ACID DEHYDROGENASE E1, ALPHA POLYPEPTIDE (BCKDHB; OMIM:248600), which when mutated leads to maple syrup urine disease, type 1a; F27D4.5 protein is predicted to be mitochondrial. 2-oxoisovalerate dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F28C6.3 Aff_F28C6.3 cpf-1; F28C6.3; 2I892; CE03274; NM_063421; WBGene00000773; WP:CE03274 cleavage stimulation factor like Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F28C6.8 Aff_F28C6.8 F28C6.8; 2I897; CE09746; WBGene00009207; WP:CE09746 MAP kinase phosphatase like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F28F8.5 Aff_F28F8.5 F28F8.5; 5Q54; CE09759; WBGene00009223; WP:CE09759 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F29A7.6 Aff_F29A7.6 F29A7.6; 2D42; CE09777; WBGene00017916; WP:CE09777 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F29B9.10 Aff_F29B9.10 F29B9.10; 4F422; CE09788; WBGene00017924; WP:CE09788 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated F29B9.2 Aff_F29B9.2 F29B9.2; 4F429; CE09781; CE27145; WBGene00017920; WP:CE09781; WP:CE27145 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F29C12.4 Aff_F29C12.4 F29C12.4; 2N411; CE19822; WBGene00009246; WP:CE19822 Elongation factor Tu family (contains ATP/GTP binding P-loop), Elongation factor G C-terminus McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated F29C4.7 Aff_F29C4.7 F29C4.7; F29C4.7a.1; F29C4.7a.2; F29C4.7b.1; F29C4.7b.2; 4A876; CE17724; CE31493; CE37226; WBGene00017929; WP:CE17724; WP:CE31493; WP:CE37226 F29C4.7 is orthologous to human RBM15 (OMIM:606077, mutated in infantile acute megakaryoblastic leukemia) and Drosophila NITO; F29C4.7 encodes a paralog of DIN-1; like DIN-1, it has N-terminal RNA recognition motifs (RRMs) and a C-terminal SID/RD (SMRT interaction domain/repressor) domain. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F29D10.4 Aff_F29D10.4 hum-1; F29D10.4; 1J422; CE05763; NM_059992; WBGene00002035; WP:CE05763 myosin McCarroll et al 2004 SFig5 conserved w/ yeast, McElwee et al 2003 T1 targets of daf-16, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F29G9.3 Aff_F29G9.3 aps-1; apt-2; F29G9.3; 5G505; CE09797; NM_072158; WBGene00000159; WP:CE09797 The apt-2 gene encodes an adaptin: specifically, it encodes an ortholog of the sigma1 subunit of adaptor protein complex 1 (AP-1). clathrin coat assembly protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F30A10.6 Aff_F30A10.6 F30A10.6; 1K67; CE09807; WBGene00009264; WP:CE09807 Yeast recessive suppressor RSD1 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F31C3.5 Aff_F31C3.5 F31C3.5; 1P647; CE17734; WBGene00009287; WP:CE17734 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F31D4.3 Aff_F31D4.3 fkb-6; F31D4.3; F31D4.3.1; F31D4.3.2; 5V317; CE15929; NM_075625; WBGene00001431; WP:CE15929 FKBP-type peptidyl-prolyl cis-trans isomerases McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F32B6.3 Aff_F32B6.3 F32B6.3; 4K646; CE35518; WBGene00009320; WP:CE35518 Human HPRP18 protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F32D1.1 Aff_F32D1.1 figl-1; F32D1.1; 5E820; CE09865; WBGene00017981; WP:CE09865 F32D1.1 encodes an homolog of human SPASTIN (OMIM:604277, mutated in spastic paraplegia), FIDGETIN (OMIM:605295, mutated in fidget mice), and FIDGETIN-LIKE-1, and of Drosophila SPASTIN; recombinant F32D1.1 protein has N-ethylmaleimide-sensitive ATPase activity in vitro, which is strongly dependent on the C368 residue immediately C-terminal to its Walker A motif; F32D1.1 is required for persistence of the germline in RNAi assays. ATPase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F32D8.6 Aff_F32D8.6 emo-1; oar-1; F32D8.6; F32D8.6.1; F32D8.6.2; 5L376; CE05785; NM_073377; WBGene00001303; WP:CE05785 emo-1 encodes an ortholog of S. cerevisiae Sec61p gamma subunit, which is required for translocation of secreted and membrane proteins into the endoplasmic reticulum; EMO-1 is required for oogenesis and ovulation. protein transport protein SEC61 gamma subunit McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F33H2.2 Aff_F33H2.2 F33H2.2; 1P619; CE17765; WBGene00009366; WP:CE17765 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F35D11.4 Aff_F35D11.4 F35D11.4; 2E893; CE32648; WBGene00018045; WP:CE32648 Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S4 Climbing, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S4 genes pass two-wayANOVA P0 F35D11.5 Aff_F35D11.5 F35D11.5; F35D11.5.1; F35D11.5.2; 2E892; CE29789; WBGene00018046; WP:CE29789 ViswanathanM et al 2005 S2 sir-2.1 regulated F35D2.3 Aff_F35D2.3 F35D2.3; 2H861; CE31804; WBGene00018041; WP:CE31804 Baugh et al 2005, PAL-1 target genes, Jones et al 2001 Non dauer genes P<0.05 F35G12.12 Aff_F35G12.12 F35G12.12; F35G12.12.1; F35G12.12.2; 3F673; CE31499; WBGene00009445; WP:CE31499 Lund et al 2002 Fig3C Germline-intrinsic, Lund et al 2002 Fig1 aging-regulated genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F35G12.6 Aff_F35G12.6 mab-21; F35G12.6; 3F691; CE32651; NM_065539; WBGene00003112; WP:CE32651 mab-21 encodes a novel protein that is a member of a highly conserved family of proteins with Drosophila and vertebrate orthologs; MAB-21 is cell-autonomously required for specifying the identity of sensory ray 6 in the male tail, and also for backward locomotion, normal body morphology, fecundity, and embryonic morphogenesis; MAB-21 expression begins in embryonic hypodermal cells and continues in larval and adult animals in hypodermis, anterior and ventral cord neurons, some body wall muscles, and ray cells. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F35H10.6 Aff_F35H10.6 F35H10.6; 4J65; CE38515; WBGene00018071; WP:CE38515 ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT F35H10.7 Aff_F35H10.7 F35H10.7; 4J63; CE04507; WBGene00018072; WP:CE04507 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F36A2.8 Aff_F36A2.8 F36A2.8; 1J389; CE32406; WBGene00009455; WP:CE32406 Drosophila sex-regulated protein janus like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F36D1.1 Aff_F36D1.1 F36D1.1; 1L870; CE19832; WBGene00009461; WP:CE19832 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F36D4.2 Aff_F36D4.2 F36D4.2; 5J881; CE07190; WBGene00018088; WP:CE07190 synbindin TRS23 family McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F36H1.1 Aff_F36H1.1 fkb-1; F36H1.1; 4L801; CE05813; NM_069655; WBGene00001426; WP:CE05813 fkb-1 encodes a homolog of mouse FK506-binding protein 2. FK506-binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated F37C12.2 Aff_F37C12.2 F37C12.2; 3I275; CE00741; WBGene00018150; WP:CE00741 Link et al 2003 T2 Abeta induced, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F37F2.2 Aff_F37F2.2 F37F2.2; 1B916; CE32185; WBGene00018159; WP:CE32185 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F38A5.1 Aff_F38A5.1 F38A5.1; 4H346; CE10028; CE33641; WBGene00018160; WP:CE10028; WP:CE33641 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F38E1.9 Aff_F38E1.9 F38E1.9; 5I838; CE04527; WBGene00018181; WP:CE04527 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated F38H4.10 Aff_F38H4.10 F38H4.10; 4M625; CE32887; WBGene00009551; WP:CE32887 Yeast hypothetical protein YIK6 like Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F38H4.8 Aff_F38H4.8 ech-2; F38H4.8; 4M616; CE17808; NM_069845; WBGene00001151; WP:CE17808 enoyl-CoA hydratase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 F39B2.4 Aff_F39B2.4 mdt-23; sur-2; F39B2.4; 1P370; CE28023; CE28024; NM_061174; WBGene00006349; WP:CE28023; WP:CE28024 SUR-2 PROTEIN Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F39B2.5 Aff_F39B2.5 F39B2.5; F39B2.5.1; F39B2.5.2; 1P354; CE34485; WBGene00009556; WP:CE34485 Src homology domain 2 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Romagnolo et al 2002 Fig3b signaling F40F9.7 Aff_F40F9.7 F40F9.7; F40F9.7a.1; F40F9.7a.2; F40F9.7b.1; F40F9.7b.2; F40F9.7b.3; F40F9.7b.4; 5K213; CE05856; CE33580; WBGene00009584; WP:CE05856; WP:CE33580 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F40G9.11 Aff_F40G9.11 mxl-2; F40G9.11; 3A804; CE19858; NM_064772; WBGene00003510; WP:CE19858 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F40G9.2 Aff_F40G9.2 F40G9.2; 3A809; CE19849; WBGene00018240; WP:CE19849 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F41E6.9 Aff_F41E6.9 F41E6.9; 5J86; CE10260; WBGene00018290; WP:CE10260 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F41H10.3 Aff_F41H10.3 F41H10.3; 4G139; CE10276; CE31694; WBGene00018316; WP:CE10276; WP:CE31694 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F41H10.6 Aff_Y4C6B.A F41H10.6; 4G122; CE20772; CE25887; WBGene00018319; WP:CE20772; WP:CE25887 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F42H10.7 Aff_F42H10.7 F42H10.7; 3J578; CE00169; CE37109; WBGene00018371; WP:CE00169; WP:CE37109 Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F42H11.2 Aff_F42H11.2 lem-3; F42H11.2; F42H11.2.1; F42H11.2.2; 1K156; CE10332; NM_060138; WBGene00002276; WP:CE10332 ankyrin domain Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F43G6.1 Aff_F43G6.1 dna-2; F43G6.1; 2M71; CE02219; CE23725; NM_064114; NM_064115; WBGene00001016; WP:CE02219; WP:CE23725 dna-2 encodes the C. elegans ortholog of the yeast and vertebrate Dna2 replication helicases; by homology, DNA-2 is predicted to function as an endonuclease and an ATP-dependent helicase that is involved in DNA replication and repair; in C. elegans, DNA-2 activity is required maternally and zygotically to maintain normal rates of cell division and for proper germ-line, embryonic, and larval development; DNA-2 activity is temperature-sensitive: animals lacking DNA-2 at 16 degrees Celsius (C) are less severely affected than those at 20 or 25 degrees C; in the hermaphrodite gonad, DNA-2 localizes to nuclei of germ cells and developing oocytes, and expression continues in embryos up to the comma stage; DNA-2 then reappears at the L3 larval stage, and in L3 and L4 larvae is visible in the proliferating somatic cells of the uterus and spermatheca. ViswanathanM et al 2005 S2 sir-2.1 regulated F43G9.12 Aff_F43G9.12 F43G9.12; 1J219; CE17822; WBGene00009672; WP:CE17822 Human GC-rich sequence DNA-binding factor (GCF) like Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen F43G9.4 Aff_F43G9.4 F43G9.4; 1J184; CE10360; WBGene00009667; WP:CE10360 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F44B9.5 Aff_F44B9.5 F44B9.5; F44B9.5.1; F44B9.5.2; 3J104; CE24973; WBGene00018408; WP:CE24973 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F44E2.8 Aff_F44E2.8 F44E2.8; 3J938; CE32420; WBGene00018421; WP:CE32420 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F44E7.9 Aff_F44E7.9 F44E7.9; 5G271; CE10396; WBGene00018431; WP:CE10396 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F45E12.5 Aff_F45E12.4 F45E12.5; F45E12.5b.1; F45E12.5b.2; 2H598; CE02741; CE32049; WBGene00018475; WP:CE02741; WP:CE32049 ViswanathanM et al 2005 S2 sir-2.1 regulated F45E4.2 Aff_F45E4.2 plp-1; F45E4.2; F45E4.2.1; F45E4.2.2; 4I399; CE10494; NM_068840; WBGene00004046; WP:CE10494 plp-1 encodes a protein containing three PUR repeats that are predicted to bind DNA/RNA and has similarity to the mammalian transcription factor pur alpha, and is required for embryonic development, development of the pharynx, and affects formation of the intestine; interacts with an Lef-1 site within the end-1 promoter and binding is regulated by phosphorylation Baugh et al 2005, PAL-1 target genes, Kwon et al 2004 T1 late-induction Ethanol-response, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b TF, ViswanathanM et al 2005 S2 sir-2.1 regulated F46B6.6 Aff_F46B6.6 F46B6.6; 5K264; CE26974; WBGene00009771; WP:CE26974 initiation factor IF-2 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F46C5.9 Aff_F46C5.9 F46C5.9; 2J100; CE10584; WBGene00009784; WP:CE10584 G-protein ViswanathanM et al 2005 S2 sir-2.1 regulated F46E10.10 Aff_F46E10.D F46E10.10; F46E10.10b.1; F46E10.10b.2; F46E10.10c.1; F46E10.10c.2; F46E10.D; F46E10.I; 5G996; CE20820; CE33096; CE33097; WBGene00018491; WP:CE20820; WP:CE33096; WP:CE33097 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Link et al 2003 T2 Abeta repressed, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F46F11.5 Aff_F46F11.5 vha-10; F46F11.5; F46F11.5.1; F46F11.5.2; F46F11.5.3; 1G178; CE10604; NM_059240; WBGene00006919; WP:CE10604 vacuolar ATPase G subunit McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol F48B9.8 Aff_F48B9.8 F48B9.8; CE04616; WBGene00018593; WP:CE04616; XC790 F48C1.6 Aff_F48C1.6 F48C1.6; 1F886; CE10742; WBGene00018599; WP:CE10742 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F49C12.11 Aff_F49C12.11 F49C12.11; F49C12.11.1; F49C12.11.2; 4K83; CE03371; WBGene00009880; WP:CE03371 ViswanathanM et al 2005 S2 sir-2.1 regulated F49C12.12 Aff_F49C12.12 phi-62; F49C12.12; F49C12.12.1; F49C12.12.2; 4K84; CE03372; WBGene00009881; WP:CE03372 ViswanathanM et al 2005 S2 sir-2.1 regulated F49C12.9 Aff_F49C12.9 F49C12.9; 4K80; CE10780; WBGene00009878; WP:CE10780 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F49E7.1 Aff_C05D9.6 rme-6; F49E7.1; CE26468; CE38712; WBGene00004377; WBGene00018633; WP:CE26468; WP:CE38712; XB721 The primary phenotype of rme-6 animals is an accumulation of secreted GFP in the pseudocoelom, suggesting a decrease in, or the absence of, endocytosis in coelomocytes. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F52A8.5 Aff_F52A8.5 F52A8.5; F52A8.5.1; F52A8.5.2; 1H922; CE05912; WBGene00009918; WP:CE05912 F52A8.5 is orthologous to the human gene GLYCINE CLEAVAGE SYSTEM PROTEIN H (GCSH; OMIM:238330), which when mutated leads to glycine encephalopathy. glycine cleavage system H protein like ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F52H2.7 Aff_F52H2.7 F52H2.7; CE31179; WBGene00018719; WP:CE31179; XD186 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol F52H3.2 Aff_F52H3.2 F52H3.2; 2K322; CE03398; WBGene00009944; WP:CE03398 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. glucose inhibited division protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F53A2.4 Aff_F53A2.4 nud-1; F53A2.4; 3O429; CE16096; NM_067348; WBGene00003829; WP:CE16096 nud-1 encodes the C. elegans ortholog of the Aspergillus nidulans nudC, which mediates nuclear migration along Aspergillus hyphae. Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F53F4.3 Aff_F53F4.3 F53F4.3; 5O73; CE10958; WBGene00009987; WP:CE10958 S.pombe hypothetical protein SPAC4G9.01 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E F54C8.3 Aff_F54C8.3 apc-4; emb-30; F54C8.3; 3K526; CE32676; NM_066673; WBGene00001284; WP:CE32676 emb-30 encodes an anaphase-promoting complex/cyclosome (APC/C) component orthologous to mammalian APC-4 and Schizosaccharomyces pombe Lid1; EMB-30 is required for the metaphase-to-anaphase transition during meiosis and mitosis, for establishing anterior-posterior polarity in the early embryo, and for proper localization of germline granules and the maternally provided PAR-2 and PAR-3 proteins. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F54C8.4 Aff_F54C8.4 F54C8.4; 3K532; CE00190; WBGene00010037; WP:CE00190 Protein-tyrosine phosphatase Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F54C9.9 Aff_F54C9.9 F54C9.9; 2I871; CE20865; WBGene00010044; WP:CE20865 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F54D5.12 Aff_Y62F5A.B F54D5.12; F54D5.12.1; F54D5.12.2; 2L830; CE26814; WBGene00010055; WP:CE26814 yeast hyothetical YET1 like protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F54D5.7 Aff_F54D5.7 F54D5.7; F54D5.7.1; F54D5.7.2; CE03411; NM_064068; WBGene00010052; WP:CE03411 The F54D5.7 gene encodes an ortholog of the human gene GLUTARYL-COENZYME A DEHYDROGENASE (GCDH), which when mutated leads to glutaricaciduria type I (OMIM:231670). acyl-CoA dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F54D8.3 Aff_F54D8.3 alh-1; F54D8.3; F54D8.3a.1; F54D8.3a.2; F54D8.3b.1; F54D8.3b.2; F54D8.3b.3; 3G169; CE29809; CE32434; NM_065680; NM_181921; WBGene00000107; WP:CE29809; WP:CE32434 alh-1 is orthologous to the human gene ALDEHYDE DEHYDROGENASE 2, MITOCHONDRIAL (ALDH2; OMIM:100650), in which a polymorphism can lead to acute ethanol intolerance. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F54E12.2 Aff_F54E12.2 F54E12.2; F54E12.2.1; F54E12.2.2; 4M98; CE11083; WBGene00010061; WP:CE11083 helicase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F54E7.1 Aff_F54E7.1 F54E7.1; 3G771; CE01312; WBGene00018827; WP:CE01312 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Transporters, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F54E7.3 Aff_F54E7.3 par-3; F54E7.3; 3G765; CE28449; CE28450; CE39941; NM_065816; WBGene00003918; WP:CE28449; WP:CE28450; WP:CE39941 par-3 encodes a PDZ domain-containing protein orthologous to mammalian atypical PKC isotype-specific interacting protein (ASIP) and Drosophila Bazooka; PAR-3 is required maternally for polarization of the zygote along the anterior-posterior (A-P) axis; PAR-3, PAR-6, and PKC-3 form a complex that localizes to the anterior cytoplasmic cortex of the one- and two-cell embryo; this localization is regulated spatially by PAR-2, which segregates to the posterior cortex. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F54G8.3 Aff_F54G8.3 ina-1; F54G8.3; 3K258; CE00205; NM_066631; WBGene00002081; WP:CE00205 Integrin alpha chain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F55A11.3 Aff_F55A11.3 F55A11.3; F55A11.3.1; F55A11.3.2; 5M249; CE05945; WBGene00010076; WP:CE05945 Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F55A12.2 Aff_F55A12.2 F55A12.2; F55A12.2d.1; F55A12.2d.2; 1F933; CE29396; CE30540; CE34317; CE34318; WBGene00018863; WP:CE29396; WP:CE30540; WP:CE34317; WP:CE34318 ViswanathanM et al 2005 S2 sir-2.1 regulated F55C5.5 Aff_F55C5.5 EF-TS; tsfm-1; F55C5.5; 5M750; CE11158; WBGene00010094; WP:CE11158 F55C5.5 encodes a translational elongation factor Ts (EF-Ts) that binds two different EF-Tu proteins (EF-TU1/Y71H2AM.23 and EF-TU2/C43E11.4) in vitro, stimulating guanine-nucleotide exchange and mRNA translation; F55C5.5 is predicted to be mitochondrial and has a putative N-terminal transit peptide sequence; F55C5.5 is required in mass RNAi assays for normally rapid growth and for maintenance of the germline. mitochondrial elongation factor TS McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, GO categories, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F55F8.5 Aff_F55F8.5 tag-345; F55F8.5; F55F8.5.1; F55F8.5.2; 1G224; CE11196; WBGene00018893; WP:CE11196 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F55H2.2 Aff_F55H2.2 vha-14; F55H2.2; F55H2.2.1; F55H2.2.2; 3K599; CE00209; NM_066693; WBGene00010130; WP:CE00209 Membrane-associated atpase gamma chain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56B3.8 Aff_F56B3.8 F56B3.8; 4B529; CE34320; WBGene00018932; WP:CE34320 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56C11.3 Aff_F56C11.3 F56C11.3; 1A656; CE17903; WBGene00018955; WP:CE17903 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F56D1.3 Aff_F56D1.3 F56D1.3; F56D1.3.1; F56D1.3.2; CE29407; WBGene00018961; WP:CE29407 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56G4.5 Aff_Y53H1C.A F56G4.5; F56G4.5.1; F56G4.5.2; 1L979; CE23786; WBGene00010160; WP:CE23786 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Thioredoxins McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F57B10.5 Aff_F57B10.5 F57B10.5; 1H139; CE11306; WBGene00019003; WP:CE11306 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F57B9.4 Aff_F57B9.4 coq-2; F57B9.4; 3I27; CE28469; CE28470; CE32444; CE32445; CE32446; NM_066111; NM_066112; NM_181953; NM_181954; WBGene00000762; WP:CE28469; WP:CE28470; WP:CE32444; WP:CE32445; WP:CE32446 coq-2 encodes a para-hydroxybenzoate-polyprenyl transferase (UbiA prenyltransferase) whose yeast ortholog is mitochondrial. ViswanathanM et al 2005 S2 sir-2.1 regulated F57B9.6 Aff_F57B9.6 inf-1; F57B9.6; F57B9.6a.1; F57B9.6a.2; 3I21; CE01341; CE38524; Ce1F; CeIF; NM_066108; WBGene00002083; WP:CE01341; WP:CE38524 inf-1 encodes a protein with high similarity to eukaryotic initiation factor 4A. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F57B9.7 Aff_T07E3.7 F57B9.7; 3I14; CE31011; CE31012; WBGene00018998; WP:CE31011; WP:CE31012 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F58A4.8 Aff_F58A4.8 sas-3; tbg-1; F58A4.8; F58A4.8.1; F58A4.8.2; 3K716; CE00224; NM_066730; TUBG; WBGene00006540; WP:CE00224 tbg-1 encodes gamma-tubulin; in C. elegans, tbg-1 activity is essential and is required for normal bipolar spindle assembly and function, as well as the fast phase of female pronuclear migration following fertilization; while tbg-1 is required for proper organization and function of kinetochore and interpolar microtubules, it does not appear to be absolutely required for microtubule nucleation and growth; TBG-1 localizes to centrosomes in both interphase and mitotic cells, exhibiting a dynamic behavior during mitosis that differs between anterior and posterior centrosomes. Gamma-like tubulin McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F58B3.5 Aff_F58B3.5 mrs-1; F58B3.5; 4M398; CE06007; NM_069795; WBGene00003415; WP:CE06007 mrs-1 encodes a predicted cytoplasmic methionyl-tRNA synthetase (MetRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of methionine to its cognate tRNA and is thus required for protein biosynthesis; MRS-1 is essential for embryogenesis and required also for a normal rate of postembryonic growth. methionyl-tRNA synthetase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol F58E10.4 Aff_F58E10.4 aip-1; F58E10.4; 5O493; CE18786; NM_074078; WBGene00000097; WP:CE18786 aip-1 encodes an AN-1-like zinc finger-containing protein homologous to arsenite-inducible RNA-associated protein (AIRAP), conserved among C. elegans, Drosophila, and mammals; like AIRAP itself, AIP-1 protects cells from arsenite toxicity; AIP-1 is a predicted RNA binding protein that may function in ubiquitin-mediated proteolysis following aresenite treatment; AIP-1 does not appear to be essential for viability, but is expressed at high levels in hypodermal and intestinal cells following such treatment. GuhaThakurta et al 2002 T1 upregu on heat stress, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Zhang et al 2002, T1 mec-3 dependent genes F58G11.6 Aff_F58G11.6 F58G11.6; 5O161; CE11410; WBGene00010283; WP:CE11410 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F58H1.1 Aff_F58H1.1 F58H1.1; 5M408; CE06025; CE39509; WBGene00010284; WP:CE06025; WP:CE39509 alpha-mannosidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F59A2.3 Aff_F59A2.3 F59A2.3; F59A2.3.1; F59A2.3.2; 3E487; CE17940; WBGene00010303; WP:CE17940 Splicing factor-associated 32K chain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F59B8.2 Aff_F59B8.2 F59B8.2; F59B8.2.1; F59B8.2.2; 4K204; CE03436; WBGene00010317; WP:CE03436 isocitrate dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 F59C6.4 Aff_F59C6.4 F59C6.4; 1L95; CE11462; WBGene00010325; WP:CE11462 McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F59E12.10 Aff_F59E12.10 ddl-1; F59E12.10; 2F936; CE11536; WBGene00019125; WP:CE11536 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E F59F4.4 Aff_F59F4.4 acl-1; F59F4.4; CE11552; NM_078205; WBGene00010339; WP:CE11552; XQ469 1-acyl-SN-glycerol-3-phosphate acyltransferase Jones et al 2001 Non dauer genes P<0.05, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched H01M10.1 Aff_H01M10.1 H01M10.1; CE19912; WBGene00019143; WP:CE19912; XD194 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol H12D21.7 Aff_H12D21.7 H12D21.7; 5P379; CE36178; WBGene00010383; WP:CE36178 Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination H13N06.4 Aff_H13N06.4 H13N06.4; CE18814; CE38383; WBGene00010397; WP:CE18814; WP:CE38383; XQ117 H13N06.4 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:12715) (SUOX; OMIM:602216), which when mutated leads to disease. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 H19N07.3 Aff_H19N07.3 H19N07.3; H19N07.3.1; H19N07.3.2; 5L598; CE16184; WBGene00010407; WP:CE16184 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination H20J04.5 Aff_H20J04_717.C tag-355; H20J04.5; H20J04.5.1; H20J04.5.2; H20J04.5.3; 2E617; CE23815; WBGene00019220; WP:CE23815 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated K01A6.2 Aff_K01A6.1 magi-1; K01A6.2; 4M493; CE37387; WBGene00010444; WP:CE37387 membrane-associated guanylate kinase homolog (MAGUK) Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 daf-16 Resveratrol K01C8.6 Aff_K01C8.6 K01C8.6; 2I566; CE02267; WBGene00010458; WP:CE02267 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ViswanathanM et al 2005 S2 sir-2.1 regulated K01C8.7 Aff_K01C8.7 K01C8.7; 2I565; CE02268; WBGene00010459; WP:CE02268 Mitochondrial carrier proteins McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K01D12.12 Aff_K01D12.12 cdr-6; K01D12.12; 5M892; CE06051; NM_073712; WBGene00010471; WP:CE06051 glutathione S-transferase ViswanathanM et al 2005 S2 sir-2.1 regulated K01G5.1 Aff_K01G5.1 tag-331; K01G5.1; 3K846; 3L846; CE26718; WBGene00010476; WP:CE26718 Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E K02B12.3 Aff_K02B12.3 phi-15; K02B12.3; K02B12.3.1; K02B12.3.2; 1J86; CE32461; WBGene00010496; WP:CE32461 WD domain, G-beta repeat McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA K02B2.1 Aff_K02B2.1 K02B2.1; 4G707; CE30082; WBGene00019295; WP:CE30082 6-phosphofructo-2-kinase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol K02D10.1 Aff_K02D10.1 K02D10.1; K02D10.1b.1; K02D10.1b.2; 3J865; CE17151; CE29423; WBGene00019301; WP:CE17151; WP:CE29423 4-NITROPHENYLPHOSPHATASE McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K04A8.6 Aff_F46E10.A F46E10.A; K04A8.6; 5H14; CE27388; WBGene00019377; WP:CE27388 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K04F10.3 Aff_K04F10.3 K04F10.3; 1G935; CE28586; WBGene00019396; WP:CE28586 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K04G2.6 Aff_K04G2.6 K04G2.6; K04G2.6.1; K04G2.6.2; 1I619; CE06100; WBGene00010565; WP:CE06100 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K04G7.4 Aff_K04G7.4 nuo-4; K04G7.4; K04G7.4a.1; K04G7.4a.2; K04G7.4a.3; K04G7.4a.4; K04G7.4b.1; K04G7.4b.2; 3I246; CE01361; CE31031; WBGene00019401; WP:CE01361; WP:CE31031 NADH dehydrogenase Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K05C4.2 Aff_K05C4.2 K05C4.2; K05C4.2.1; K05C4.2.2; 1P312; CE19970; WBGene00010579; WP:CE19970 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K05C4.6 Aff_K05C4.6 hmp-2; K05C4.6; KO5C4.6; 1P333; CE19974; NM_061165; WBGene00001979; WP:CE19974 hmp-2 encodes a beta-catenin; HMP-2 activity is required during embryonic development for cell adhesion at adherens junctions, cell migration, and body morphogenesis; as a beta-catenin, HMP-2 likely functions solely as part of a cadherin-catenin complex, as in yeast two-hybrid assays, HMP-2 is the only C. elegans beta-catenin that binds HMP-1/alpha-catenin and HMR-1/cadherin; additionally, in the embryo, HMP-2 co-localizes to sites of epithelial cell contacts with HMP-1 and HMR-1/cadherin; however, despite its normal role in embryonic cell adhesion, HMP-2 can activate transcription and when overexpressed in vivo, can partially rescue vulval defects produced by loss of BAR-1/beta-catenin, suggesting that HMP-2 has retained the ability to interact with the Wnt signaling pathway. Armadillo/beta-catenin-like repeats (4 domains) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K07A1.9 Aff_K07A1.9 K07A1.9; 1K188; CE32465; CE32466; CE32467; WBGene00010615; WP:CE32465; WP:CE32466; WP:CE32467 arginyl-tRNA protein transferase like (truncated) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K07A3.1 Aff_K07A3_50.C fbp-1; K07A3.1; K07A3.1.1; K07A3.1.2; K07A3.1.3; K07A3.B; 1D150; CE21023; NM_058603; WBGene00001404; WP:CE21023; fbp fbp-1 encodes fructose 1,6-bisphosphatase, a gluconeogenic enzyme that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate in a reaction that reverses the third enzymatic step of glycolysis; in C. elegans, loss of fbp-1 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities; FBP-1 is orthologous to human FBP1 (OMIM:229700, mutated in FBP deficiency). fructose-bisphosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K07B1.4 Aff_K07B1.4 K07B1.4; K07B1.4b.1; K07B1.4b.2; 5J811; CE11882; CE27391; WBGene00019464; WP:CE11882; WP:CE27391 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, McElwee et al 2003 T1 targets of daf-16, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K07B1.7 Aff_K07B1.7 K07B1.7; 5J826; CE29509; CE38846; WBGene00019467; WP:CE29509; WP:CE38846 Lund et al 2002 Fig3C Germline-intrinsic, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K07C5.1 Aff_K07C5.1 arx-2; K07C5.1; 5K816; CE06111; NM_073256; WBGene00000200; WP:CE06111 actin McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated K07G5.2 Aff_K07G5.2 xpa-1; K07G5.2; 1H737; CE06130; NM_059624; WBGene00006963; WP:CE06130 xpa-1 encodes an ortholog of human XPA, the xeroderma pigmentosum complementation group A protein (OMIM:278700, mutations are associated with sensitivity to ultraviolet light and carcinomata at an early age); by homology, XPA-1 is predicted to function as a DNA-binding protein that is required for nucleotide excision repair of damaged DNA; in C. elegans, loss of xpa-1 activity via mutation or RNA-mediated interference (RNAi) results in increased sensitivity to UV irradiation at all stages of development; xpa-1 mRNA is detected in eggs and mixed stage populations. DNA-repair protein XP-A homolog like Golden et al 2004, N2 vs daf-2 age different gene, Golden et al 2004, N2 differentially expressed gen, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K07H8.1 Aff_K07H8.1 K07H8.1; 4J61; CE18021; WBGene00019503; WP:CE18021 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K07H8.3 Aff_K07H8.3 K07H8.3; 4J55; CE18023; WBGene00019505; WP:CE18023 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K08D10.4 Aff_K08D10.4 rnp-2; K08D10.4; 4E937; CE28597; NM_068103; WBGene00004385; WP:CE28597 U1 small nuclear ribonucleoprotein A Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated K08F4.2 Aff_K08F4.2 K08F4.2; 4K892; CE37535; WBGene00010677; WP:CE37535 RNA recognition motif. (aka RRM, RBD, or RNP domain) Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated K08F9.2 Aff_K08F9.2 tag-216; K08F9.2; K08F9.2.1; K08F9.2.2; K08F9.2.3; 5P616; CE11944; WBGene00010685; WP:CE11944 beta-transducin like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA K08H10.7 Aff_K08H10.7 rde-1; K08H10.7; 5K468; CE28243; NM_171525; WBGene00004323; WP:CE28243 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K08H10.9 Aff_K08H10.9 K08H10.9; 5K473; CE18881; WBGene00010699; WP:CE18881 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K08H2.6 Aff_K08H2.6 hpl-1; K08H2.6; CE06164; NM_077798; WBGene00001995; WP:CE06164; XN865 The hpl-1 gene encodes a homolog of heterochromatin protein 1 (HP1) that acts to support the activity of HPL-2 in promoting germline function, but that by itself is dispensable for any obvious function in vivo. murine modifier 2 protein like ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K10B3.8 Aff_K10B3.8 gpd-2; K10B3.8; CE07371; NM_076134; WBGene00001684; WP:CE07371; XD732 gpd-2 encodes one of four C. elegans glyceraldehyde-3-phosphate dehydrogenases (GAPDHs); by homology, GPD-2 is predicted to reversibly catalyze the oxidation and phosphorylation of glyceraldehyde-3-phosphate to 1,3-diphosphoglycerate during glycolysis; in C. elegans, GPD-2 and GPD-3 constitute the major GAPDH isoenzymes and are expressed at highest levels during postembryonic development, primarily in the actin-containing A and I zones of body-wall muscle; loss of gpd-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Roy et al 2002 S3 muscle genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 K10D2.6 Aff_K10D2.6 emb-8; K10D2.6; K10D2.6.1; K10D2.6.2; 3G286; CE02018; WBGene00001262; WBGene00019632; WP:CE02018 Uncloned locus required for embryonic viability, for the normal generation of anterior-posterior asymmetry in the early embryo, and for normal P Granule and GLP-1 asymmetry in early embryos. NADPH-cytochrome P450 Custodia et al 2001 T2 Cytochrome P450, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph K11B4.2 Aff_K11B4.2 K11B4.2; 1P391; CE23868; WBGene00010767; WP:CE23868 K11G12.5 Aff_K11G12.5 K11G12.5; CE02827; WBGene00019656; WP:CE02827; XH342 mitochondrial 2-oxoglutartae McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K11H12.1 Aff_K11H12.1 K11H12.1; 4B404; CE12146; WBGene00019658; WP:CE12146 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. DNA-binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K11H12.8 Aff_K11H12.8 K11H12.8; 4B411; CE12160; CE31566; WBGene00019664; WP:CE12160; WP:CE31566 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph K11H3.1 Aff_K11H3.1 K11H3.1; K11H3.1b.1; K11H3.1b.2; 3K944; CE31850; CE31851; WBGene00010778; WP:CE31850; WP:CE31851 K11H3.1 encodes one of two C. elegans glycerol 3-phosphate dehydrogenases; although loss of K11H3.1 activity via large-scale RNAi screens results in no obvious defects, expression of a K11H3.1 cDNA in Saccharomyces cerevisiae hog1 mutants is able to rescue the high osmolarity-sensitive growth phenotype of these mutants, suggesting that K11H3.1 encodes a functional glycerol 3-phosphate dehydrogenase. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K12H4.4 Aff_K12H4.4 phi-20; K12H4.4; K12H4.4.1; K12H4.4.2; 3J133; CE00269; WBGene00019679; WP:CE00269 Signal peptidase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b secretion, ViswanathanM et al 2005 S2 sir-2.1 regulated M01B12.3 Aff_M01B12.3 arx-7; M01B12.3; 1D638; CE18061; NM_058698; WBGene00000205; WP:CE18061 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated M01D7.4 Aff_M01D7.4 tag-96; M01D7.4; 1C323; CE36705; WBGene00006461; WBGene00019707; WP:CE36705 galactokinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph M01E11.1 Aff_M01E11.1 M01E11.1; 1G151; CE12288; WBGene00019710; WP:CE12288 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated M01F1.6 Aff_M01F1.6 M01F1.6; M01F1.6.1; M01F1.6.2; 3E601; CE37982; WBGene00010812; WP:CE37982 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph M02B7.2 Aff_M02B7.2 M02B7.2; 4E569; CE12322; WBGene00019724; WP:CE12322 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated M03F4.7 Aff_M03F4.7 M03F4.7; CE12368; CE34060; WBGene00019760; WP:CE12368; WP:CE34060; XF588 calcium binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Zhang et al 2002, T1 mec-3 dependent genes M04B2.3 Aff_M04B2.3 gfl-1; M04B2.3; 4M287; CE12388; NM_069771; WBGene00001585; WP:CE12388 gfl-1 encodes an ortholog of human GLIOMA-AMPLIFIED SEQUENCE-41 (GAS41; OMIM:602116, found in increased copy number in low-grade glioma); loss of GLF-1, which is predicted to associate with chromatin, results in potent suppression of the RNA interference (RNAi) mechanism; GLF-1 is also similar to the transcription factors (yeast and human) AF-9 and human ENL, and thus may represent a novel class of transcription factors. Human AF-9 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated M05D6.2 Aff_M05D6.2 M05D6.2; 2I759; CE03500; WBGene00010875; WP:CE03500 testis-specific like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E M142.8 Aff_M142.5 M142.8; 3M25; CE37540; WBGene00043057; WP:CE37540 M176.2 Aff_M176.2 M176.2; M176.2.1; M176.2.2; 2J706; CE18087; WBGene00010941; WP:CE18087 M176.2 is orthologous to the human gene GLUTATHIONE SYNTHETASE (GSS; OMIM:601002), which when mutated leads to 5-oxoprolinuria, or to GSS deficiency restricted to erythrocytes and associated only with hemolytic anemia. glutathione synthase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA M70.4 Aff_M70.4 M70.4; 4D18; CE37266; WBGene00019786; WP:CE37266 M70.4 is orthologous to human O-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE (FLJ20277; OMIM:606822), which when mutated leads to muscle-eye-brain disease. M88.2 Aff_M88.2 M88.2; 3F630; CE23884; WBGene00010905; WP:CE23884 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes PAR2.1 Aff_PAR2.1 PAR2.1; PAR2.1.1; PAR2.1.2; 3J859; CE00768; WBGene00019800; WP:CE00768 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R03A10.4 Aff_R03A10.4 R03A10.4; R03A10.4a.1; R03A10.4a.2; R03A10.4b.1; R03A10.4b.2; CE29335; CE37983; WBGene00010984; WP:CE29335; WP:CE37983; XQ61 gluamine-phenylpyruvate transaminase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated R05D11.6 Aff_R05D11.6 R05D11.6; 1J173; CE32473; WBGene00011034; WP:CE32473 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen R05F9.6 Aff_R05F9.6 R05F9.6; 2F181; CE04809; WBGene00019890; WP:CE04809 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. phosphoglucomutase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched R06C7.5 Aff_R06C7.5 R06C7.5; R06C7.5b.1; R06C7.5b.2; 1H824; CE06248; CE32476; WBGene00011064; WP:CE06248; WP:CE32476 The R06C7.5 gene encodes an ortholog of the human gene ADSL, which when mutated leads to adenylosuccinate lyase deficiency (OMIM:103050). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated R07E4.4 Aff_R07E4.4 mig-23; R07E4.4; R07E4.4.1; R07E4.4.2; CE28748; NM_076593; WBGene00003254; WP:CE28748; XG566 guanosine-diphosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated R07E5.13 Aff_R07E5.13 R07E5.13; 3F505; CE00659; WBGene00011119; WP:CE00659 This gene encodes a homolog of mammalian BRAIN PROTEIN 44-LIKE (BRP44L). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 R07E5.14 Aff_R07E5.14 rnp-4; R07E5.14; R07E5.14.1; R07E5.14.2; 3F497; CE01044; NM_065490; WBGene00004387; WP:CE01044 rnp-4 encodes a putative member of the exon-exon junction complex, orthologous to Y14 in S. cerevisiae and TSUNAGI in D. melanogaster; RNP-4 is required for embryonic viability, fertility, vulval development, and cuticular integrity; however, rnp-4(RNAi) animals show no accumulation of poly(A)+ mRNA in their nuclei, indicating that RNP-4 is dispensable for mRNA export. RNA binding domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R07E5.2 Aff_R07E5.2 prdx-3; R07E5.2; R07E5.2.1; R07E5.2.2; 3F499; CE00657; NM_065491; WBGene00011110; WP:CE00657; ceprx1 Mer5 (mouse) Golden et al 2004, N2 vs daf-2 age different gene, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b Oxidation, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 R07E5.7 Aff_R07E5.7 R07E5.7; R07E5.7.1; R07E5.7.2; 3F510; CE00672; WBGene00011115; WP:CE00672 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R07H5.3 Aff_R07H5.3 R07H5.3; 4L951; CE12554; CE35186; WBGene00011123; WP:CE12554; WP:CE35186 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated R08B4.3 Aff_R08B4.3 R08B4.3; CE20025; WBGene00011139; WP:CE20025; XL738 ViswanathanM et al 2005 S2 sir-2.1 regulated R08D7.1 Aff_R08D7.1 R08D7.1; 3K56; CE00289; WBGene00011142; WP:CE00289 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated R08D7.2 Aff_R08D7.2 R08D7.2; 3K59; CE00290; WBGene00011143; WP:CE00290 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated R08D7.8 Aff_R08D7.4 R08D7.8; CE33293; WBGene00011148; WP:CE33293 Reinke et al 2004, wt herm vs wt male enriched gen R09B3.1 Aff_R09B3.1 exo-3; R09B3.1; 1M498; CE16306; CE38407; NM_060620; WBGene00001372; WP:CE16306; WP:CE38407 exo-3 encodes an ortholog of human APEX/REF1 and rat apurinic/apyrimidinic endonuclease (AP endonuclease 1); EXO-3 is implicated in a DNA damage checkpoint pathway that affects embryonic and larval viability. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated R09B3.4 Aff_R09B3.4 ubc-12; R09B3.4; 1M503; CE16309; NM_060623; WBGene00006707; WP:CE16309 The ubc-12 gene encodes a ubiquitin-conjugating enzyme whose substrate is NED-8, and which is required for both embryogenesis and terminal hypodermal differentiation; ubc-12(RNAi) mutants either arrest during embryonic development or show pleotropic defects (e.g., vulval eversion during the L4 stage), as well as defective alae. Ubiquitin-conjugating enzymes ViswanathanM et al 2005 S2 sir-2.1 regulated R09F10.8 Aff_R09F10.8 R09F10.8; R09F10.8.1; R09F10.8.2; CE28756; WBGene00019989; WP:CE28756; XI944 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R107.7 Aff_R107.7 gst-1; R107.7; R107.7.1; R107.7.2; 3K149; CE00302; NM_066605; WBGene00001749; WP:CE00302 gst-1 encodes a putative glutathione S-transferase with highest similarity to the pi class. glutathione S-transferase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination R10D12.13 Aff_R10D12.13 R10D12.13; 5O445; CE12696; CE23920; CE23921; WBGene00011194; WP:CE12696; WP:CE23920; WP:CE23921 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated R10E11.3 Aff_R10E11.3 R10E11.3; R10E11.3a.1; R10E11.3a.2; 3K867; CE23922; CE23923; WBGene00011216; WP:CE23922; WP:CE23923 Ubiquitin-specifc processing protease Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen R10E11.8 Aff_R10E11.8 vha-1; R10E11.8; R10E11.8.1; R10E11.8.2; R10E11.8.3; 3K871; CE06291; NM_066764; WBGene00006910; WP:CE06291 vha-1 encodes a 16-kDa proteolipid of the vacuolar-type H+-ATPase (V-ATPase) and is required for embryogenesis and for oocyte ovulation, based on RNAi analysis; expressed in the excretory cells and the rectum of adult animals as well as in a pair of cells posterior to the anus. ATP synthase subunit C (2 domains) Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C R10H10.6 Aff_R10H10.6 R10H10.6; 4L172; CE06297; WBGene00011224; WP:CE06297 Yeast protein YD8419.03c like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA R119.3 Aff_R119.3 R119.3; 1A848; CE28758; WBGene00020089; WP:CE28758 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. dehydrogenase Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated R11E3.7 Aff_R11E3.7 dpf-7; R11E3.7; 4F564; CE19549; CE31721; NM_171328; NM_171329; WBGene00001060; WP:CE19549; WP:CE31721 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated R11E3.8 Aff_R11E3.8 dpf-5; R11E3.8; R11E3.8.1; R11E3.8.2; R11E3.8.3; 4F568; CE29985; NM_068246; WBGene00001058; WP:CE29985 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated R11H6.2 Aff_R11H6.2 R11H6.2; R11H6.2.1; R11H6.2.2; 5P79; CE12772; WBGene00011250; WP:CE12772 Human placenta (DIFF33) protein like Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R12C12.2 Aff_R12C12.2 ran-5; R12C12.2; R12C12.2.1; R12C12.2.2; 2G339; CE02847; NM_062807; WBGene00004306; WP:CE02847 ran-5 encodes a protein containing a RanBP1 domain, domains which are predicted to interact with Ran proteins to inhibit dissociation of GTP and to stimulate GAP-mediated GTP hydrolysis by Ran, that affects body morphology, locomotion, and embryonic viability. Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated R12C12.6 Aff_R12C12.6 R12C12.6; 2G336; CE02851; CE39619; WBGene00020026; WP:CE02851; WP:CE39619 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated R13A5.7 Aff_R13A5.7 R13A5.7; 3I656; CE30389; WBGene00020050; WP:CE30389 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated R13G10.2 Aff_R13G10.2 amx-1; R13G10.2; 3E915; CE25088; NM_065371; WBGene00000137; WP:CE25088 monoamine oxidase Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R151.8 Aff_R151.8 R151.8; 3I318; CE27201; WBGene00020111; WP:CE27201 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated R166.3 Aff_R166.3 R166.3; 2K828; CE03582; WBGene00011303; WP:CE03582 The R166.3 gene encodes an unfamiliar protein, with homologs in yeast and archaea, that is orthologous to the human gene ALPORT SYNDROME, MENTAL RETARDATION, MIDFACE HYPOPLASIA, AND ELLIPTOCYTOSIS CHROMOSOMAL REGION GENE 1 (AMMECR1; OMIM:300195); AMMECR1, when mutated, may be at least partially responsible for mental retardation, midface hypoplasia, or elliptocytosis. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R186.3 Aff_R186.3 R186.3; 5N446; CE12874; WBGene00011306; WP:CE12874 signal recognition particle receptor beta subunit like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R53.1 Aff_R53.1 R53.1; R53.1a.1; R53.1a.2; R53.1b.1; R53.1b.2; CE02303; CE38215; WBGene00011271; WP:CE02303; WP:CE38215 FAD-1 like protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated R53.2 Aff_R53.2 R53.2; 2K254; CE03571; WBGene00011272; WP:CE03571 thymidylate kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T01E8.5 Aff_T01E8.5 T01E8.5; 2K534; CE18165; WBGene00011333; WP:CE18165 Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T01E8.6 Aff_T01E8.6 T01E8.6; T01E8.6.1; T01E8.6.2; 2K532; CE32923; WBGene00011334; WP:CE32923 mitochondrial ribosomal protein S14 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T02G5.8 Aff_T02G5.8 kat-1; T02G5.8; 2H367; CE29990; NM_063054; WBGene00002183; WP:CE29990 kat-1 encodes a homolog of the human gene ACAT1, which when mutated leads to alpha-methylacetoaceticaciduria (OMIM:203750). acetoacetyl-C0A thiolase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T03D8.2 Aff_T03D8.2 T03D8.2; 5V309; CE18920; WBGene00011391; WP:CE18920 Ribosomal protein S12 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T03F1.1 Aff_T03F1.1 T03F1.1; 1E443; CE13096; WBGene00020184; WP:CE13096 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T03F1.3 Aff_T03F1.3 T03F1.3; 1E435; CE13100; WBGene00020185; WP:CE13100 T03F1.3 is orthologous to the human gene PHOSPHOGLYCERETE KINASE 1 (PGK1; OMIM:311800), which when mutated leads to hemolytic anemia and neurologic disturbances. phosphoglycerate kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 T03F6.2 Aff_T03F6.2 dnj-17; T03F6.2; 3O480; CE16336; NM_067358; WBGene00001035; WP:CE16336 This gene encodes a protein containing a DnaJ ('J') domain. DnaJ, prokaryotic heat shock protein, Zinc finger, C2H2 type McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated T04A11.6 Aff_T04A11.6 blm-1; him-6; T04A11.6; 4N259; CE31724; NM_069989; WBGene00001865; WP:CE31724 him-6 encodes a RecQ-like ATP-dependent DNA helicase orthologous to human BLM (OMIM:604610, mutated in Bloom syndrome); HIM-6 is required for normal levels of recombination during meiosis and as such, loss of HIM-6 function results in an increased frequency of genotypically XO males and inviable aneuoploid embryos as a result of higher levels of chromosome nondisjunction; HIM-6 interacts both genetically and in vitro with TOP-3, DNA topoisomerase IIIalpha, with which it functions to regulate genomic stability during germ-line mitosis; HIM-6 is expressed primarily in the germ line. helicase Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen T04A8.11 Aff_T04A8.11 T04A8.11; 3F793; CE01066; WBGene00011412; WP:CE01066 50S ribosomal protein L16 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T04A8.12 Aff_T04A8.12 tag-189; T04A8.12; 3F795; CE01067; WBGene00007045; WBGene00011413; WP:CE01067 Yeast 107.9KD PGK1-MAK32 intergenic hypothetical protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T04A8.16 Aff_T04A8.16 clp-2; T04A8.16; 3F790; CE01070; NM_065563; WBGene00000543; WP:CE01070 clp-2 encodes a large calpain subunit that contains two predicted MIT (microtubule interacting and trafficking) domains and is homologous to the mammalian Calpain 7 proteins and the atypical, nuclear-localized Aspergillus calpain, PalB; by homology, CLP-2 is predicted to function as a calcium-dependent, cysteine protease that is involved in intracellular proteolysis and peptidolysis; however, as loss of clp-2 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of CLP-2 in C. elegans development and/or behavior is not yet known. Calpain thiol protease T04A8.6 Aff_T04A8.6 T04A8.6; 3F782; CE01075; WBGene00011408; WP:CE01075 ribonuleoprotein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T04A8.9 Aff_T04A8.9 dnj-18; T04A8.9; T04A8.9.1; T04A8.9.2; 3F787; CE01078; NM_065561; WBGene00001036; WP:CE01078 This gene encodes a protein containing a DnaJ ('J') domain. DNAJ Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T04C10.2 Aff_T04C10.2 epn-1; T04C10.2; CE26820; CE26821; NM_078057; NM_078058; WBGene00001329; WP:CE26820; WP:CE26821; XP436 Yeast hypothetical protein L8167.6 like ViswanathanM et al 2005 S2 sir-2.1 regulated T04D3.5 Aff_T04D3.5 T04D3.5; 1N922; CE13161; WBGene00011434; WP:CE13161 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T05A6.1 Aff_T05A6.1 cki-1; T05A6.1; 2I101; CE03628; NM_063240; WBGene00000516; WP:CE03628 cki-1 encodes a homolog of the mammalian cyclin-dependent kinase inhibitor p27/KIP1 that is required for the arrest of cell division in larval blast lineages, dauer larvae and starved L1 larvae; excess CKI-1 expression prematurely stops cell division while cki-1(RNAi) induces extra cell divisions, indicating that CKI-1 quantitatively regulates the amount of mitosis in postembryonic worms. Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order T05C12.6 Aff_T05C12.6 mig-5; T05C12.6; 2I474; CE02318; CE25100; CE28076; WBGene00003241; WP:CE02318; WP:CE25100; WP:CE28076 mig-5 encodes one of three C. elegans Dishevelled homologs; as part of both canonical and non-canonical Wnt signaling pathways, mig-5 activity is required maternally and embryonically for cell migration, cell fate specification, and proper spindle orientation in the early embryo; cells affected by mig-5 mutations include the distal tip cells (DTCs), the QL neuroblast descendants (QL.d), the vulval precursor cells, and the P12 ectoblast; in the early embryo, MIG-5 functions downstream of MOM-2/Wnt and MOM-1/Porc, and redundantly with two other Dishevelled homologs, DSH-1 and DSH-2, in a non-canonical Wnt pathway that specifies the endoderm cell fate and regulates mitotic spindle orientation in the EMS and ABar blastomeres; in posteriorly directed QL.d migrations, MIG-5 functions downstream of EGL-20/Wnt and upstream of PRY-1/Axin in a canonical Wnt pathway to positively regulate Wnt signaling and effect MAB-5 expression in QL.d; a mig-5::GFP fusion is reportedly expressed in many cells in the embryo, migrating DTCs, P cells, and the nerve ring. presynaptic density protein (PSD-95) repeat-like domain Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T05E11.3 Aff_T05E11.3 T05E11.3; T05E11.3.1; T05E11.3.2; 4L887; CE06362; WBGene00011480; WP:CE06362 endoplasmin precursor (GRP94) Lund et al 2002 Aging time course Fig2C heatshock, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated T05E11.5 Aff_T05E11.5 imp-2; T05E11.5; 4L882; CE06364; NM_069678; WBGene00011481; WP:CE06364 Yeast YKK0 like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T05F1.1 Aff_T05F1.1 T05F1.1; T05F1.1.1; T05F1.1.2; 1K197; CE13267; WBGene00011488; WP:CE13267 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T05F1.4 Aff_T05F1.4 T05F1.4; CE13261; NM_060157; WBGene00011490; WP:CE13261 ViswanathanM et al 2005 S2 sir-2.1 regulated T05G5.6 Aff_T05G5.6 ech-6; T05G5.6; T05G5.6.1; T05G5.6.2; 3K842; CE00318; NM_066755; WBGene00001155; WP:CE00318 Enoyl-CoA hydratase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 T05H4.13 Aff_T05H4.13 alh-4; T05H4.13; T05H4.13c.1; T05H4.13c.2; 5G908; CE27441; CE30827; CE33307; NM_072233; NM_171471; NM_171472; WBGene00000110; WP:CE27441; WP:CE30827; WP:CE33307 aldehyde dehydrogenase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T06D8.9 Aff_T06D8.9 T06D8.9; T06D8.9.1; T06D8.9.2; 2L531; CE38219; WBGene00011529; WP:CE38219 Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated T06E4.3 Aff_T06E4.3 Ce-atl1; atl-1; T06E4.3; 5K116; CE25103; CE28250; NM_073086; WBGene00000226; WP:CE25103; WP:CE28250 The atl-1 gene encodes a large, 2514-residue protein of the ATM family, homologous to human AT (OMIM:208900, mutated in ataxia telangiectasia); the C-terminal sequence of ATL-1 contains a PI-3 kinase-like domain; ATL-1 is required for survival through early embryogenesis and normal chromosomal segregation; atl-1 is expressed in both the mitotic and meiotic cells of adult gonads. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes T06E8.1 Aff_T06E8.1 acl-2; T06E8.1; 5K510; CE06378; NM_073177; WBGene00011543; WP:CE06378 T06E8.1 is orthologous to the human gene 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 2 (LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE, BETA) (AGPAT2; OMIM:603100), which when mutated leads to disease; T06E8.1 protein is predicted to be mitochondrial. 1-acyl-SN-glycerol-3-phophate acyltransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T06H11.4 Aff_T06H11.4 moc-1; T06H11.4; CE31596; NM_077299; WBGene00003384; WP:CE31596; XK756 moc-1 encodes an ortholog of human GEPHYRIN (GPHN; OMIM:603930), which when mutated leads to molybdenum cofactor (MoCo) deficiency; MOC-1 is also paralogous to LIN-46. gephyrin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated T07C4.1 Aff_T07C4.1 T07C4.1; T07C4.1.1; T07C4.1.2; 3L446; CE00638; WBGene00011559; WP:CE00638 T07C4.1 is orthologous to the human gene URIDINE MONOPHOSPHATE SYNTHETASE (OROTATE PHOSPHORIBOSYL TRANSFERASE AND OROTIDINE-5'-DECARBOXYLASE) (UMPS; OMIM:258900), which when mutated leads to disease. UMP synthase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T07E3.5 Aff_T07E3.5 brc-2; T07E3.5; 3H990; CE32718; NM_066101; WBGene00020316; WP:CE32718 The T07E3.5 gene encodes a single BRC domain (in residues 12-109) that might promote double-stranded DNA break repair; eight tandem BRC domains are encoded by the central coding region of the human BRCA2 gene, which when mutated leads to early-onset breast cancer 2 or hereditary male breast cancer (OMIM:600185). Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T08D10.2 Aff_T08D10.2 T08D10.2; CE33174; WBGene00011615; WP:CE33174; XM569 T08D10.2 encodes an ortholog of the human histone demethylase LSD1 (KIAA0601), and a paralog of C. elegans SPR-5; similar histone demethylase homologs are found in human, mouse, Drosophila, fission yeast, and Arabidopsis; T08D10.2 is predicted to demethylate histone H3 lysine 4 residues and act as a transcriptional corepressor. corticosteroid-binding protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T09A5.5 Aff_T09A5.5 T09A5.5; T09A5.5.1; T09A5.5.2; 2I142; CE01086; WBGene00011634; WP:CE01086 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated T09A5.6 Aff_T09A5.6 mdt-10; T09A5.6; 2I144; CE01087; NM_063249; WBGene00007014; WP:CE01087 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes T09A5.7 Aff_T09A5.7 T09A5.7; T09A5.7.1; T09A5.7.2; 2I146; CE01088; WBGene00011635; WP:CE01088 T09A5.9 Aff_T09A5.9 T09A5.9; T09A5.9.1; T09A5.9.2; T09A5.9.3; 2I149; CE01090; WBGene00011637; WP:CE01090 SDS22 protein Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset T09B4.10 Aff_T09B4.10 chn-1; tag-69; T09B4.10; T09B4.10.1; T09B4.10.2; 1G758; CE29991; NM_059380; WBGene00000500; WP:CE29991 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E T09B4.2 Aff_T09B4.2 T09B4.2; 1G761; CE13459; WBGene00020376; WP:CE13459 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T09E8.3 Aff_T09E8.3 T09E8.3; 5N661; CE23961; WBGene00011648; WP:CE23961 cornichon protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T10B5.6 Aff_T10B5.6 knl-3; T10B5.6; 5C349; CE18236; NM_071119; WBGene00020392; WP:CE18236 Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated T10C6.6 Aff_T10C6.6 T10C6.6; T10C6.6a.1; T10C6.6a.2; T10C6.6a.3; T10C6.6b.1; T10C6.6b.2; T10C6.6b.3; T10C6.6b.4; T10C6.6b.5; 5Q507; CE16381; CE23965; WBGene00011688; WP:CE16381; WP:CE23965 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ViswanathanM et al 2005 S2 sir-2.1 regulated T10E9.1 Aff_T10E9.1 T10E9.1; 1H121; CE13543; WBGene00020411; WP:CE13543 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T10H9.3 Aff_T10H9.3 T10H9.3; 5H134; CE18251; WBGene00020425; WP:CE18251 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T12A2.15 Aff_T12A2.14 T12A2.14; T12A2.15; 3H314; CE18255; CE30392; WBGene00020443; WP:CE18255; WP:CE30392 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T12A2.7 Aff_T12A2.7 T12A2.7; 3H334; CE30396; WBGene00020441; WP:CE30396 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T12B3.3 Aff_T12B3.B T12B3.3; T12B3.B; 4I141; CE21178; WBGene00020446; WP:CE21178 phosphodiesterase T12B3.4 Aff_T12B3.A T12B3.4; 4I150; CE21179; WBGene00020447; WP:CE21179 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T12D8.2 Aff_T12D8.2 drr-2; T12D8.2; T12D8.2.1; T12D8.2.2; 3O734; CE16399; WBGene00011730; WP:CE16399 RNA recognition motif. (aka RRM, RBD, or RNP domain) Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T12D8.6 Aff_T12D8.6 T12D8.6; 3O713; CE16403; WBGene00011734; WP:CE16403 EF hand McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T12D8.8 Aff_T12D8.8 T12D8.8; T12D8.8.1; T12D8.8.2; T12D8.8.3; 3O704; CE16405; WBGene00011735; WP:CE16405 TPR Domain (2 domains) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T12F5.1 Aff_T12F5.1 T12F5.1; 1E311; CE13595; WBGene00020466; WP:CE13595 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T12G3.4 Aff_T12G3.4 T12G3.4; 4M813; CE06440; WBGene00011739; WP:CE06440 strictosidine synthase like ViswanathanM et al 2005 S2 sir-2.1 regulated T12G3.5 Aff_T12G3.5 T12G3.5; T12G3.5.1; T12G3.5.2; 4M795; CE06441; WBGene00011740; WP:CE06441 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T13H5.5 Aff_T13H5.5 T13H5.5; 2I817; CE03656; WBGene00011759; WP:CE03656 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen T14B4.2 Aff_T14B4.2 T14B4.2; 2H27; CE04952; WBGene00020499; WP:CE04952 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T17E9.2 Aff_T17E9.2 T17E9.2; T17E9.2c.1; T17E9.2c.2; 3H204; CE01406; CE28669; CE31611; WBGene00020549; WP:CE01406; WP:CE28669; WP:CE31611 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T19A5.1 Aff_T19A5.1 T19A5.1; T19A5.1.1; T19A5.1.2; 5J441; CE07509; WBGene00020553; WP:CE07509 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T19B4.4 Aff_T19B4.4 dnj-21; T19B4.4; T19B4.4.1; T19B4.4.2; 1G245; CE13742; NM_059261; WBGene00001039; WP:CE13742 This gene encodes a protein containing a DnaJ ('J') domain. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T20B12.1 Aff_T20B12.1 T20B12.1; 3I479; CE01407; WBGene00020600; WP:CE01407 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T20D3.3 Aff_T20D3.3 T20D3.3; T20D3.3a.1; T20D3.3a.2; 4K98; CE28683; CE38418; WBGene00011857; WP:CE28683; WP:CE38418 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T20F10.2 Aff_T20F10.2 T20F10.2; 1K875; CE21191; WBGene00011864; WP:CE21191 ViswanathanM et al 2005 S2 sir-2.1 regulated T20F7.1 Aff_T20F7.1 T20F7.1; CE33698; WBGene00020630; WP:CE33698; XR491 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen T20G5.10 Aff_T20G5.10 T20G5.10; 3L300; CE00629; WBGene00011872; WP:CE00629 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T20G5.9 Aff_T20G5.9 T20G5.9; 3L299; CE34095; WBGene00011871; WP:CE34095 T20H4.3 Aff_T20H4.3 prs-1; T20H4.3; T20H4.3a.1; T20H4.3a.2; 3I329; CE00748; CE37410; WBGene00004189; WP:CE00748; WP:CE37410 prs-1 encodes a predicted cytoplasmic prolyl-tRNA synthetase (ProRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of proline to its cognate tRNA and is thus required for protein biosynthesis; PRS-1 is required for embryonic, germline, and postembryonic development. McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T21B10.1 Aff_T21B10.1 T21B10.1; 2J221; CE03683; WBGene00011883; WP:CE03683 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T21B10.2 Aff_T21B10.2 T21B10.2; T21B10.2a.1; T21B10.2a.2; 2J223; CE03684; CE32730; CE36954; WBGene00011884; WP:CE03684; WP:CE32730; WP:CE36954 T21B10.2 is orthologous to human ENOLASE 1 (also CRYSTALLIN, TAU; ENO1; OMIM:172430), which when mutated leads to spherocytic red cell enolase deficiency. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T21C9.5 Aff_T21C9.5 lpd-9; T21C9.5; T21C9.5.1; T21C9.5.2; 5L61; CE06474; NM_073313; WBGene00003065; WP:CE06474 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T22C1.3 Aff_T22C1.3 T22C1.3; 1I515; CE39412; WBGene00011914; WP:CE39412 cell division control protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T23B12.2 Aff_T23B12.2 T23B12.2; 5I949; CE14028; WBGene00020717; WP:CE14028 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ribosomal protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T23B12.3 Aff_T23B12.3 T23B12.3; 5I947; CE14030; WBGene00020718; WP:CE14030 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. ribosomal protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated T23D8.4 Aff_T23D8.4 eif-3.C; T23D8.4; T23D8.4.1; T23D8.4.2; 1K554; CE18958; NM_060237; WBGene00001226; WP:CE18958 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T23F11.4 Aff_T23F11.4 T23F11.4; 3F754; CE01097; WBGene00011956; WP:CE01097 Zinc finger protein (C2H2 type) ViswanathanM et al 2005 S2 sir-2.1 regulated T24B8.2 Aff_T24B8.2 T24B8.2; 2J345; CE03710; WBGene00011976; WP:CE03710 Yeast SNF7 like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, Romagnolo et al 2002 Fig3b secretion, ViswanathanM et al 2005 S2 sir-2.1 regulated T24D1.4 Aff_T24D1.4 tag-179; T24D1.4; 1K538; CE14168; WBGene00007043; WBGene00011987; WP:CE14168 Yeast DIE2 protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T24H10.6 Aff_T24H10.6 dyrb-1; T24H10.6; 2J396; CE03731; NM_063542; WBGene00012004; WP:CE03731 bithoraxoid-like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated T25B9.8 Aff_T25B9.8 T25B9.8; 4L532; CE32940; WBGene00012014; WP:CE32940 lin-15a like protein Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T25D3.2 Aff_T25D3.2 T25D3.2; 2A446; CE19599; WBGene00020796; WP:CE19599 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated T25G3.3 Aff_T25G3.3 T25G3.3; T25G3.3.1; T25G3.3.2; CE30306; NM_059713; WBGene00012030; WP:CE30306 Yeast nonsense-mediated mRNA decay protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T26A5.6 Aff_T26A5.6 T26A5.6; T26A5.6.1; T26A5.6.2; 3H538; CE29822; WBGene00020822; WP:CE29822 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T26G10.1 Aff_T26G10.1 T26G10.1; 3K494; CE00337; WBGene00012059; WP:CE00337 RNA helicase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated T27E9.2 Aff_T27E9.2 T27E9.2; T27E9.2.1; T27E9.2.2; 3O550; CE14265; WBGene00012094; WP:CE14265 ubiquinol-cytochrome c reductase complexn 11 KD protein Golden et al 2004, N2 vs daf-2 different genes at , Golden et al 2004, daf-2 differentially expressed , Golden et al 2004, N2 vs daf-2 age different gene T27E9.3 Aff_T27E9.3 cdk-5; T27E9.3; 3O554; CE21213; NM_067382; WBGene00000407; WP:CE21213 cdk-5 encodes a putative homolog of cyclin dependent kinase 5 that affects pronuclear migration and rotation in one-cell embryos and may affect neuronal development; expressed in neurons. serine/threonine kinase (CDC2/CDKX subfamily) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E T27E9.4 Aff_T27E9.4 kel-3; T27E9.4; T27E9.4a.1; T27E9.4a.2; T27E9.4a.3; 3O559; CE29824; CE29825; NM_067383; NM_067384; WBGene00002185; WP:CE29824; WP:CE29825 ring canal protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T27F7.1 Aff_F59A6.7 T27F7.1; T27F7.1.1; T27F7.1.2; CE27211; NM_062518; WBGene00020866; WP:CE27211 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated VF36H2L.1 Aff_VF36H2L.1 aph-1; pen-1; VF36H2L.1; 1J808; CE16526; NM_060068; WBGene00000147; WP:CE16526 aph-1 encodes an unfamiliar protein predicted to have seven transmembrane domains; APH-1 is a component of the GLP-1/LIN-12 (Notch) pathway, is required maternally for embryonic viability, and also affects morphogenesis, egg laying, germ line proliferation, and translocation of APH-2 to the cell surface; with PEN-2, APH-1 is required for Notch pathway signaling, gamma-secretase cleavage of beta-amyloid precursor protein, and presenilin protein accumulation. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated W01D2.5 Aff_W01D2.5 W01D2.5; 2P99; CE20128; WBGene00012182; WP:CE20128 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated W01G7.3 Aff_W01G7.3 W01G7.3; 2O351; CE18986; WBGene00012187; WP:CE18986 RNA polymerases L / 13 to 16 Kd subunit Lund et al 2002 Fig3C Germline-intrinsic, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated W02A11.2 Aff_W02A11.2 W02A11.2; 1N326; CE24025; WBGene00012193; WP:CE24025 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated W02A11.3 Aff_W02A11.3 W02A11.3; W02A11.3.1; W02A11.3.2; 1N331; CE18990; WBGene00012194; WP:CE18990 Zinc finger, C3HC4 type (RING finger) ViswanathanM et al 2005 S2 sir-2.1 regulated W02B12.10 Aff_W02B12.10 W02B12.10; 2L762; CE03770; WBGene00012205; WP:CE03770 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated W02D3.2 Aff_W02D3.2 W02D3.2; 1H315; CE14420; WBGene00020932; WP:CE14420 dihydroorotate dehydrogenase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated W02D9.2 Aff_W02D9.2 W02D9.2; 1N125; CE14456; WBGene00012208; WP:CE14456 Yeast YIP1 protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated W02F12.4 Aff_W02F12.4 W02F12.4; 5H186; CE39790; CE39791; CE39792; WBGene00020949; WP:CE39790; WP:CE39791; WP:CE39792 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated W02F12.5 Aff_W02F12.5 W02F12.5; W02F12.5.1; W02F12.5.2; W02F12.5.3; 5H188; CE31083; WBGene00020950; WP:CE31083 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. dihydrolipoamide succinyltransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated W03F9.2 Aff_W03F9.2 W03F9.2; 5A606; CE14526; CE24030; WBGene00021000; WP:CE14526; WP:CE24030 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated W05H7.3 Aff_W05H7.3 sedl-1; W05H7.3; CE14652; NM_075871; WBGene00021046; WP:CE14652; XC58 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol W05H9.2 Aff_W05H9.2 W05H9.2; CE33720; WBGene00021049; WP:CE33720; XG889 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated W07G4.4 Aff_W07G4.4 W07G4.4; 5N525; CE03794; WBGene00012338; WP:CE03794 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. cytosolic aminopeptidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated W08E3.3 Aff_W08E3.3 tag-210; W08E3.3; 1N935; CE14708; WBGene00012344; WBGene00044075; WP:CE14708 GTP-binding protein like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated W09B6.4 Aff_W09B6.4 W09B6.4; 2B424; CE39038; CE39801; WBGene00021104; WP:CE39038; WP:CE39801 ViswanathanM et al 2005 S2 sir-2.1 regulated W09D10.3 Aff_W09D10.3 W09D10.3; 3L797; CE16564; WBGene00012361; WP:CE16564 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. ribosomal protein L7/L12 mitochondrial Golden et al 2004, N2 vs daf-2 age different gene, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA W10D9.4 Aff_W10D9.4 W10D9.4; 2A752; CE14792; WBGene00021132; WP:CE14792 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y105E8B.2 Aff_Y105E8A.Y Y105E8B.2; Y105E8B.2b.1; Y105E8B.2b.2; 1P228; CE28785; CE34105; WBGene00013687; WP:CE28785; WP:CE34105 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma Y105E8B.5 Aff_Y105E8A.K Y105E8B.5; 1P253; CE24099; WBGene00013690; WP:CE24099 The Y105E8B. Y106G6H.14 Aff_Y106G6H.14 Y106G6H.14; 1L48; CE24111; WBGene00013724; WP:CE24111 Src homology domain 3 ; Ank repeat Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated Y106G6H.15 Aff_Y106G6H.15 Y106G6H.15; 1L50; CE20424; WBGene00013725; WP:CE20424 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y111B2A.20 Aff_Y111B2A.AA Y111B2A.20; Y111B2E.B; 3N803; CE24129; WBGene00013740; WP:CE24129 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y113G7A.3 Aff_Y113G7A.N sec-23; Y113G7A.3; Y113G7A.3.1; Y113G7A.3.2; 5U575; CE27230; NM_075476; WBGene00004754; WP:CE27230 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y113G7A.9 Aff_Y113G7A.K dcs-1; hsl-1; Y113G7A.9; 5U558; CE23280; DcpS; NM_075475; WBGene00000940; WP:CE23280 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y113G7B.23 Aff_Y113G7B.L psa-1; Y113G7B.23; 5U710; CE25208; NM_075505; WBGene00004203; WP:CE25208 psa-1 encodes an ortholog of SWI3, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-1 is probably required during mitosis of the T cells for asymmetric cell division, and in addition, is required for embryonic and larval development, as well as normal levels of fertility; psa-1 exhibits strong genetic interactions with lin-35/Rb, as psa-1 larval lethality and sterility at 20 degrees C are greatly enhanced in lin-35;psa-1 double mutants. SWI/SNF protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y11D7A.10 Aff_Y11D7A.10 Y11D7A.10; Y11D7A.10.1; Y11D7A.10.2; 4K24; CE20193; WBGene00012434; WP:CE20193 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y11D7A.12 Aff_Y11D7A.12 Y11D7A.12; 4K28; CE35915; WBGene00012435; WP:CE35915 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y14H12B.1 Aff_Y14H12B_90.B Y14H12B.1; 2E225; CE21365; CE32075; CE39810; WBGene00021191; WP:CE21365; WP:CE32075; WP:CE39810 zinc-finger protein Jiang et al 2001 Fig1 hermaphrodite-enriched TF, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y17G7B.7 Aff_Y17G7B.7 tpi-1; Y17G7B.7; Y17G7B.7.1; Y17G7B.7.2; 2M328; CE19040; NM_064162; TPI; WBGene00006601; WP:CE19040 tpi-1 is orthologous to the human gene TRIOSEPHOSPHATE ISOMERASE 1 (TPI1; OMIM:190450), which when mutated leads to disease. Triosephosphate isomerase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y18D10A.16 Aff_Y18D10A.O Y18D10A.16; 1N494; CE21412; WBGene00012483; WP:CE21412 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y19D10A.16 Aff_C01B4.H Y19D10A.16; WBGene00044734 Y23H5A.2 Aff_Y23H5A.2 Y23H5A.2; 1D191; CE18358; WBGene00021269; WP:CE18358 Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y24D9A.8 Aff_Y24D9A_29.F Y24D9A.8; Y24D9A.8a.1; Y24D9A.8a.2; Y24D9A.8a.3; Y24D9A.8b.1; Y24D9A.8b.2; 4F153; CE28974; CE30402; WBGene00021286; WP:CE28974; WP:CE30402 Y24D9A.8 is orthologous to the human gene TRANSALDOLASE 1 (TALDO1; OMIM:602063), which when mutated leads to disease. Y24F12A.1 Aff_Y24F12A.B Y24F12A.1; 4M371; CE28111; WBGene00012496; WP:CE28111 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y34D9A.1 Aff_Y34D9A_151.C, Aff_Y34D9A_153.A Y34D9A.1; 1B494; CE27249; WBGene00021327; WP:CE27249 Bishop et al 2004 T1 Upregulated in vhl-1 vs WT, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y37D8A.1 Aff_Y37D8A.1 arx-5; Y37D8A.1; 3N906; CE20206; NM_067266; WBGene00000203; WP:CE20206 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y37D8A.13 Aff_Y37D8A.13 adm-1; max-3; unc-71; Y37D8A.13; 3N972; CE20217; NM_067279; WBGene00006804; WP:CE20217 unc-71 encodes an ADAM, a disintegrin and metalloprotease-containing transmembrane protein that is a member of the metzincin superfamily of proteases; UNC-71 is required non-cell autonomously for motor axon guidance and sex myoblast migration; UNC-71 does not appear to have an active metalloprotease domain, but functions with UNC-6/netrin and integrins INA-1/PAT-3 to provide guidance cues during axonal migration; UNC-71 is expressed in a restricted pattern in the excretory and excretory gland cells, some head neurons, the sphincter muscles, and hypodermal cells surrounding the vulva. Disintegrin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E Y37D8A.18 Aff_Y37D8A.18 Y37D8A.18; 3O17; CE20222; WBGene00012556; WP:CE20222 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated Y37E11B.3 Aff_Y37E11B.3 Y37E11B.3; 4E346; CE19613; WBGene00021376; WP:CE19613 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y37E11B.6 Aff_Y37E11B.6 Y37E11B.6; 4E362; CE19616; WBGene00021378; WP:CE19616 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E Y38A8.1 Aff_Y38A8.1 ndx-3; Y38A8.1; 2F243; CE07570; NM_062511; WBGene00003580; WP:CE07570 The ndx-3 gene encodes a homolog of peroxisomal CoA diphosphatases in both S. cerevisiae (PCD1) and C. elegans (NDX-8); more generally, NDX-3 protein belongs to the family of NUDIX hydrolases. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y38F2AR.2 Aff_Y38F2A_6126.I Y38F2AR.2; Y38F2AR.2.1; Y38F2AR.2.2; Y38F2A_6126.I; 4D153; CE21634; WBGene00021420; WP:CE21634 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y39A1A.12 Aff_Y39A1A.12 Y39A1A.12; Y39A1A.12.1; Y39A1A.12.2; 3L735; CE19131; WBGene00012650; WP:CE19131 Y39A1A.12 encodes a homolog of origin recognition complex 1, which is also a distant paralog of CDC-6; both Y39A1A.12 and CDC-6 encode homologs of the origin complex which, in yeast, controls the start of DNA replication; whether either Y39A1A.12 or CDC-6 are required for this function in C. elegans, individually or in parallel, is unknown. ATPases associated with various cellular activities (AAA) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E Y39A1A.14 Aff_Y39A1A.14 Y39A1A.14; 3L739; CE19133; WBGene00012652; WP:CE19133 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated Y39A1A.3 Aff_Y39A1A.3 Y39A1A.3; 3L682; CE19121; WBGene00012643; WP:CE19121 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y39A1C.2 Aff_Y39A1C.2 oxi-1; Y39A1C.2; 3L955; CE19147; NM_066991; WBGene00003898; WP:CE19147 HECT-domain (ubiquitin-transferase). McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y39A3CR.4 Aff_Y39A3C_83.D ddp-1; tim-8; tin-8; Y39A3CR.4; 3C949; CE21655; NM_065066; WBGene00000941; WP:CE21655 ddp-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Tim8p and human deafness/dystonia peptide (DDP; OMIM:300356, mutated in Mohr-Tranebjaerg syndrome); by homology, DDP-1 is predicted to be part of a heterooligomeric complex that localizes to the mitochondrial intermembrane space and facilitates translocation of proteins from the cytosol to the inner mitochondrial membrane; loss of ddp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, indicating that ddp-1 is not essential for C. elegans development or may function redundantly with its paralogs, TIN-9, -10, and -13. ViswanathanM et al 2005 S2 sir-2.1 regulated Y39B6A.13 Aff_Y39B6.S Y39B6A.13; Y39B6B.S; 5T592; CE21694; WBGene00012675; WP:CE21694 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E Y39G8B.2 Aff_Y39G8B.D Y39G8B.2; 2O264; CE24244; WBGene00012723; WP:CE24244 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Shen et al 2005 T1 hif-1indepen hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated Y39H10A.7 Aff_Y39H10A_224.A chk-1; Y39H10A.7; Y39H10A.7b.1; Y39H10A.7b.2; Y39H10A_224.A; 5E232; CE26076; CE33867; WBGene00000498; WP:CE26076; WP:CE33867 chk-1 encodes a CHK1-like serine threonin protein kinase that affects fertility. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, male germline, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination Y40B10A.1 Aff_Y40B10A_106.C lbp-9; Y40B10A.1; Y40B10A.1b.1; Y40B10A.1b.2; 5C547; CE26077; CE39188; NM_071161; WBGene00021486; WP:CE26077; WP:CE39188 Reinke et al 2004, herm soma enriched genes Y40B10A.8 Aff_Y40B10A_107.B nhr-86; Y40B10A.8; 5C540; CE31110; NM_071160; WBGene00003676; WP:CE31110 Y41C4A.10 Aff_Y41C4A.10 elb-1; Y41C4A.10; 3L686; 3M808; CE20250; NM_067116; WBGene00001235; WP:CE20250 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated Y41C4A.9 Aff_Y41C4A.9 Y41C4A.9; Y41C4A.9.1; Y41C4A.9.2; Y41C4A.9.3; 3M800; CE20249; WBGene00012756; WP:CE20249 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y41E3.8 Aff_Y41E3.8 Y41E3.8; 4P792; CE18376; WBGene00012766; WP:CE18376 Y42G9A.6 Aff_Y42G9A_141.B Y42G9A.6; Y42G9A.6b.1; Y42G9A.6b.2; Y42G9A.A; Y42G9A.B; 3H232; CE33223; CE39827; WBGene00021535; WP:CE33223; WP:CE39827 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, herm soma enriched genes Y43C5A.5 Aff_Y43C5A.5 thk-1; Y43C5A.5; 4L44; CE19154; NM_069485; WBGene00006568; WP:CE19154 thymidine kinases Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated Y43F4B.2 Aff_Y43F4B.2 Y43F4B.2; 3O384; CE39650; WBGene00012801; WP:CE39650 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y43F4B.5 Aff_Y43F4B.5 Y43F4B.5; Y43F4B.5a.1; Y43F4B.5a.2; 3O391; CE16630; CE34117; WBGene00012803; WP:CE16630; WP:CE34117 Phosphoglucomutase and phosphomannomutase phosphoserine McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y43F8C.8 Aff_Y116F11.ZZ6 Y43F8C.8; 5U119; CE21906; WBGene00012830; WP:CE21906 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y45F10A.6 Aff_Y45F10A.6 Y45F10A.6; 4O242; CE18397; CE19171; WBGene00012868; WP:CE18397; WP:CE19171 Probable rabGAP domains McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y45F10D.4 Aff_Y45F10D.4 Y45F10D.4; 4O549; CE16643; WBGene00012885; WP:CE16643 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y46H3A.6 Aff_Y46H3A.A gly-7; Y46H3A.6; Y46H3A.A; 5C296; CE24309; NM_071111; WBGene00001632; WP:CE24309 gly-7 encodes an N-acetylgalactosaminyltransferase that exhibits activity when expressed in COS7 cells. N-acetylgalactosaminyltransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y46H3A.7 Aff_Y46H3A.H Y46H3A.7; CE38646; WBGene00044344; WP:CE38646 Y47D3A.4 Aff_Y47D3A.G cku-70; Y47D3A.4; 3M257; CE28984; NM_067037; WBGene00000519; WP:CE28984 ViswanathanM et al 2005 S2 sir-2.1 regulated Y47G6A.12 Aff_Y47G6A_246.B sep-1; stu-4; Y47G6A.12; 1E2; CE22098; NM_058759; WBGene00004775; WP:CE22098 The sep-1 gene encodes a homolog of separase, a protease that splits segregating chromosomes at their centromeres during anaphase by proteolyzing the Scc1 subunit of cohesin. McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order Y47G6A.6 Aff_Y47G6A_241.B pcaf-1; Y47G6A.6; 1E91; CE24372; NM_058772; WBGene00021636; WP:CE24372 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y48A6B.11 Aff_Y48A6B.11 Y48A6B.11; 3M157; CE24379; CE34514; WBGene00012972; WP:CE24379; WP:CE34514 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order Y48B6A.13 Aff_Y48B6A.L Y48B6A.13; Y48B6A.13b.1; Y48B6A.13b.2; 2O512; CE22128; CE22129; WBGene00012984; WP:CE22128; WP:CE22129 Y48C3A.10 Aff_Y48C3A.K Y48C3A.10; 2N629; CE22143; WBGene00012992; WP:CE22143 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y48E1C.4 Aff_Y48E1C.3 Y48E1C.4; 2N724; CE32977; CE32978; WBGene00013017; WP:CE32977; WP:CE32978 Y49A3A.2 Aff_Y49A3A.C phi-51; vha-13; Y49A3A.2; Y49A3A.2.1; Y49A3A.2.2; Y49A3A.2.3; Y49A3A.2.4; Y49A3A.B; Y49A3A.C; CE22210; NM_074158; WBGene00013025; WP:CE22210 ATP synthase alpha and beta subunits ; ATP synthase ab C terminal McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y49A3A.5 Aff_Y49A3A.D cyn-1; cyp-1; Y49A3A.5; Y49A3A.5.1; Y49A3A.5.2; 5O837; CE22213; NM_074160; WBGene00000877; WP:CE22213 cyp-1 encodes a functional cyclophilin that is predicted to be secreted; expression increases as worms progress from the L1 larval stage to the adult stage. Peptidyl-prolyl cis-trans isomerase Y49E10.1 Aff_Y49E10.C rpt-6; Y49E10.1; Y49E10.B; Y49E10.C; 3N461; CE22219; NM_067208; WBGene00004506; WP:CE22219 rpt-6 encodes a triple A ATPase that is a subunit of the 26S proteasome 19S regulatory particle (RP) base subcomplex; RPT-6 is required for embryonic and larval development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome. ATPases associated with various cellular activities (AAA) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated Y49E10.2 Aff_Y49E10.D Y49E10.2; Y49E10.D; 3N462; CE22220; WBGene00013029; WP:CE22220 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y50D7A.10 Aff_Y50D7_161.A Y50D7A.10; Y50D7A.10.1; Y50D7A.10.2; Y50D7A.10.3; 3A937; CE39439; WBGene00021758; WP:CE39439 Y50E8A.4 Aff_Y50E8A.D unc-61; Y50E8A.4; 5P212; CE24405; CE32023; NM_074237; NM_182356; WBGene00006795; WP:CE24405; WP:CE32023 unc-61, by alternative splicing, encodes two septin isoforms required (like the septin UNC-59) for normal axonal migration, distal tip cell migration, and postembryonic cytokinesis (at the cellular level) and for normal locomotion and formation of the postembryonic vulva, somatic gonad, and male tail (at the organismal level); both UNC-61A/B and UNC-59 are dispensable for embryonic cytokinesis and development, but are thought to be required for all postembryonic cytokinesis; UNC-61A/B and UNC-59 depend on each other for localization to the cytokinetic furrow. Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y51H1A.4 Aff_Y51H1A.4 Y51H1A.4; Y51H1A.4.1; Y51H1A.4.2; CE20286; WBGene00013095; WP:CE20286 Y51H1A.4 is orthologous to the human gene P33ING1B (ING1; OMIM:601566), which when mutated leads to disease. PHD-finger. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated Y52B11A.2 Aff_Y52B11A.2 Y52B11A.2; 1L558; CE20291; CE36243; WBGene00013122; WP:CE20291; WP:CE36243 Uncharacterized protein family UPF0029 McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, GO categories Y52B11A.3 Aff_Y52B11A.3 Y52B11A.3; 1L571; CE20292; CE34125; WBGene00013123; WP:CE20292; WP:CE34125 Heme-binding domain in cytochrome b5 and oxidoreductases Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y53C12B.1 Aff_Y53C12B.1 Y53C12B.1; 2K34; CE14894; WBGene00013143; WP:CE14894 WD domain, G-beta repeats (4 domains) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y53F4B.3 Aff_Y53F4B.D Y53F4B.3; Y53F4B.D; 2P254; CE22389; WBGene00013150; WP:CE22389 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes Y53F4B.4 Aff_Y53F4B.F Y53F4B.4; Y53F4B.F; 2P261; CE35679; CE39655; WBGene00013151; WP:CE35679; WP:CE39655 Y54E10A.7 Aff_Y54E10A_159.B Y54E10A.7; Y54E10A_159.B; 1D731; CE38572; WBGene00021829; WP:CE38572 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y54E10BR.5 Aff_Y54E10B_159.D Y54E10BR.5; 1D598; CE22466; WBGene00021844; WP:CE22466 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y54G2A.18 Aff_Y94H6A_148.O Y54G2A.18; Y54G2A.18.1; Y54G2A.18.2; Y94H6A_148.O; CE25462; WBGene00021883; WP:CE25462 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y54G2A.36 Aff_Y94H6A_148.S Y54G2A.36; 4D661; CE34417; WBGene00021898; WP:CE34417 Y55F3AR.2 Aff_Y55F3A_750.A Y55F3AR.2; Y55F3A_750.E; 4B849; CE34418; WBGene00021933; WP:CE34418 Y56A3A.21 Aff_Y56A3A.S Y56A3A.21; Y56A3A.21.1; Y56A3A.21.2; Y56A3A.S; 3N11; CE22589; WBGene00013238; WP:CE22589 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y57A10A.16 Aff_Y57A10A.O Y57A10A.16; 2M498; CE22619; WBGene00013259; WP:CE22619 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57E12AL.1 Aff_Y57E12_242.B Y57E12AL.1; Y57E12AL.1a.1; Y57E12AL.1a.2; 5H541; CE29890; CE29891; WBGene00021956; WP:CE29890; WP:CE29891 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57G11C.13 Aff_Y57G11C.13 Y57G11C.13; 4P563; CE14950; WBGene00013309; WP:CE14950 ADP-ribosylation factor Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57G11C.15 Aff_Y57G11C.15 Y57G11C.15; Y57G11C.15.1; Y57G11C.15.2; Y57G11C.15.3; 4P588; CE14954; WBGene00013311; WP:CE14954 protein transport protein SEC61 alpha subunit McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y60A3A.19 Aff_Y60A3.C Y60A3A.19; 5U389; CE38458; WBGene00013365; WP:CE38458 Y62E10A.8 Aff_Y62E10.B phlp-1; Y62E10A.8; 4O143; CE22697; NM_070173; WBGene00013377; WP:CE22697 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y63D3A.7 Aff_Y63D3A.7 Y63D3A.7; Y63D3A.7.1; Y63D3A.7.2; Y63D3A.7.3; 1O705; CE39300; WBGene00013406; WP:CE39300 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y65B4BR.8 Aff_Y65B4B_10.C Y65B4BR.8; 1B7; CE27304; WBGene00022043; WP:CE27304 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y66H1B.4 Aff_Y66H1B.4 spl-1; Y66H1B.4; 4B134; CE20348; NM_067512; WBGene00004981; WP:CE20348; spl McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y67D8A.1 Aff_Y67D8A_386.A Y67D8A.1; Y67D8A.1.1; Y67D8A.1.2; 4E15; CE31660; WBGene00022058; WP:CE31660 Y67D8A.1 is orthologous to the human gene PHOSPHORYLASE KINASE, BETA SUBUNIT (PHKB; OMIM:172490), which when mutated leads to glycogen storage disease. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y6D11A.2 Aff_Y6D11A_150.A arx-4; tag-286; Y6D11A.2; 3B481; CE30060; WBGene00021170; WP:CE30060 Y71F9AL.5 Aff_Y71F9A_282.A gst-43; Y71F9AL.5; 1D471; CE25559; NM_058669; WBGene00001791; WP:CE25559 glutathione S-transferase Y71F9AM.5 Aff_Y71F9A_279.B nxt-1; Y71F9AM.5; Y71F9AM.5.1; Y71F9AM.5.2; 1D499; CE26780; NM_058676; NXT1; WBGene00003836; WP:CE26780 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma Y71G12B.14 Aff_Y71G12A_187.B lsm-6; Y71G12B.14; 1C175; CE22886; NM_058482; WBGene00003080; WP:CE22886 U6 small nuclear RNA-associated Sm-like protein LSm6 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y73F8A.27 Aff_Y73F8A.DD Y73F8A.27; Y73F8A.27.1; Y73F8A.27.2; 4Q237; CE25595; WBGene00013532; WP:CE25595 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y75B12B.5 Aff_Y75B12B.5 cyn-3; cyp-3; Y75B12B.5; Y75B12B.5.1; Y75B12B.5.2; 5P671; CE20374; NM_074350; WBGene00000879; WP:CE20374 cyp-3 encodes an abundantly expressed cyclophilin A isoform with peptidyl-prolyl isomerase activity in vitro, which closely resembles the prototypical CypA and is thus likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; cyp-3 is exclusively expressed in the single anterior excretory cell, and is dispensable for viability and gross morphology in mass RNAi screens. Peptidyl-prolyl cis-trans isomerases McCarroll et al 2004 SFig5 conserved w/ yeast Y75B8A.14 Aff_Y75B8A.R Y75B8A.14; 3N306; CE23026; WBGene00013550; WP:CE23026 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes Y75B8A.30 Aff_Y75B8A.NN pph-4.1; Y75B8A.30; 3N436; CE23041; NM_067202; WBGene00004085; WP:CE23041 Ser/Thr protein phosphatase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y76A2B.4 Aff_Y76A2B.4 Y76A2B.4; 3O634; CE19276; WBGene00013576; WP:CE19276 Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y79H2A.6 Aff_Y79H2A.F arx-3; Y79H2A.6; 3N122; CE24672; NM_067169; WBGene00000201; WP:CE24672 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y82E9BR.14 Aff_Y119D3_446.D Y82E9BR.14; Y82E9BR.14a.1; Y82E9BR.14a.2; 3C500; CE27038; CE34433; WBGene00022347; WP:CE27038; WP:CE34433 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y87G2A.7 Aff_Y87G2A.L Y87G2A.7; 1O167; CE23136; WBGene00013596; WP:CE23136 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y8G1A.2 Aff_Y8G1A.2 inx-13; opu-13; Y8G1A.2; 1E318; CE18356; NM_058811; WBGene00002135; WP:CE18356 inx-13 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; INX-13 is essential for larval development and osmoregulation, and may be a component of the gap junctions that link the excretory and hypodermal cells; INX-13 is expressed embryonically in hypodermis and post-embryonically, in hypodermal seam cells, the excretory cell, and the developing vulva and spermatheca; in hypodermal cells, INX-13 localizes to the plasma membrane at points of contact between adjacent cells. membrane protein; probably a channel protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig3b Transporters, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZC302.2 Aff_ZC302.2 ZC302.2; 5L219; CE06574; WBGene00013862; WP:CE06574 guanine nucleotide binding protein Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC376.5 Aff_ZC376.5 trm-1; ZC376.5; 5O664; CE15201; NM_074112; Trm1; WBGene00006613; WP:CE15201 N2,N2-dimethylguanosine tRNA methyltransferase Jones et al 2001 Non dauer genes P<0.05, Lund et al 2002 Fig3D Oocyte-en, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA ZC376.6 Aff_ZC376.6 ZC376.6; 5O671; CE15203; WBGene00013877; WP:CE15203 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC410.2 Aff_ZC410.2 ZC410.2; ZC410.2.1; ZC410.2.2; 4J839; CE35701; WBGene00013880; WP:CE35701 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. mitochondrial processing peptidase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC434.7 Aff_ZC434.7 ZC434.7; ZC434.7.1; ZC434.7.2; 1K923; CE06582; WBGene00013893; WP:CE06582 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1098.4 Aff_ZK1098.4 ZK1098.4; 3K633; CE00367; WBGene00014221; WP:CE00367 GCN3 (yeast transcription activator) McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Protein Synthesis, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1098.5 Aff_ZK1098.5 ZK1098.5; 3K615; CE00368; WBGene00014222; WP:CE00368 ZK1098.5 encodes a unfamiliar protein that is individually dispensable for viability and gross morphology in RNAi assays, but is cotranscribed with ZK1098.1 and thus might act in concert with it. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1098.7 Aff_ZK1098.7 ZK1098.7; ZK1098.7.1; ZK1098.7.2; 3K612; CE00566; WBGene00014224; WP:CE00566 Romagnolo et al 2002 Fig3b Unkown, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA ZK1236.3 Aff_ZK1236.3 phi-57; ZK1236.3; 3J511; CE00532; WBGene00023405; WP:CE00532 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1248.3 Aff_ZK1248.3 ehs-1; ZK1248.3; 2G113; CE02903; CE32289; NM_062754; WBGene00001224; WP:CE02903; WP:CE32289 The ehs-1 gene encodes an ortholog of mammalian EPS15 that probably functions in endocytosis. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1290.4 Aff_ZK1290.4 gei-21; nfi-1; ZK1290.4; ZK1290.4b.1; ZK1290.4b.2; 2H831; CE37597; CE38016; CE38017; WBGene00003592; WP:CE37597; WP:CE38016; WP:CE38017 Nuclear factor 1 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1307.5 Aff_ZK1307.5 spe-2; sqv-8; ZK1307.5; 2J939; CE01694; NM_063675; WBGene00005026; WP:CE01694 The sqv-8 gene encodes a glucuronyl transferase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos and for vulval morphogenesis; SQV-8 is homologous to three distinct glucuronyl transferases (GlcAT-I, GlcAT-P and GlcAT-D) that play a role in the synthesis of different glycoconjugates; the common requirement for SQV-8 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E ZK1320.1 Aff_ZK1320.1 ZK1320.1; 2J947; CE01698; WBGene00014251; WP:CE01698 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1320.6 Aff_ZK1320.6 arc-1; arl-4; ZK1320.6; 2J967; CE37598; NM_063688; WBGene00000180; WP:CE37598 arc-1 encodes a member of the ARL (ADP-ribosylation factor(ARF)-like) family of proteins which are very similar to ARF proteins but lack the ability to stimulate ADP ribosylation by cholera toxin; arc-1 has a human homolog, MID1, which when mutated leads to Opitz syndrome (OMIM:300000). ADP-ribosylation factors (Arf family) (contains ATP/GTP binding P-loop), Zinc finger, C3HC4 type (RING finger) ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK180.3 Aff_ZK180.3 ZK180.3; ZK180.3b.1; ZK180.3b.2; ZK180.3b.3; 4F274; CE07621; CE33959; WBGene00022677; WP:CE07621; WP:CE33959 Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit ZK180.4 Aff_ZK180.4 ZK180.4; 4F278; CE07622; WBGene00022678; WP:CE07622 GTP-binding protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK265.6 Aff_ZK265.6 ZK265.6; 1I831; CE15299; WBGene00013958; WP:CE15299 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , ViswanathanM et al 2005 S2 sir-2.1 regulated ZK265.9 Aff_ZK265.5 ZK265.9; 1I830; CE38132; WBGene00044094; WP:CE38132 Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK353.6 Aff_ZK353.6 lap-1; ZK353.6; ZK353.6.1; ZK353.6.2; 3J490; CE00390; NM_066453; WBGene00002249; WP:CE00390 The lap-1 gene encodes a homolog of the zinc metalloprotease leucine aminopeptidase LAP that is predicted to be mitochondrial. Leucine aminopeptidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA ZK418.5 Aff_ZK418.5 ZK418.5; 3I162; CE28189; WBGene00022734; WP:CE28189 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA ZK546.2 Aff_ZK546.2 ZK546.2; 2F237; CE07632; CE36076; CE36077; WBGene00022759; WP:CE07632; WP:CE36076; WP:CE36077 Adenylate cyclase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK593.8 Aff_ZK593.8 ZK593.8; 4L703; CE28722; WBGene00014004; WP:CE28722 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK632.5 Aff_ZK632.5 ZK632.5; 3K901; CE00422; WBGene00014014; WP:CE00422 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK637.2 Aff_ZK637.2 ZK637.2; ZK637.2.1; ZK637.2.2; 3J979; CE32292; WBGene00014022; WP:CE32292 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK652.3 Aff_ZK652.3 ZK652.3; 3I949; CE00449; WBGene00022784; WP:CE00449 ZK652.3 encodes a conserved eukaryotic protein with a ubiquitin-like fold. ViswanathanM et al 2005 S2 sir-2.1 regulated ZK686.3 Aff_ZK686.3 ZK686.3; 3I858; CE00457; WBGene00022793; WP:CE00457 ZK686.3 is orthologous to the putative tumor suppressor N33 (OMIM:601385, associated with homozygous deletion in metastatic prostate cancer and with loss of function in other tumors); ZK686.3 is also homologous to the S. cerevisiae dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain (34-kD) subunit, OST3. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK792.6 Aff_ZK792.6 let-60; lin-34; ZK792.6; 4M454; CE03827; NM_069812; WBGene00002335; WP:CE03827 The let-60 gene encodes a member of the GTP-binding RAS protooncogene family that affects viability, vulval development, spicule development, germ line meiotic progression, posterior development of the hypodermis, and chemotaxis; it acts genetically downstream of let-23 with respect to vulval development and upstream of the MAPK pathway with respect to chemotaxis, and is expressed in neural, muscle, and hypodermal lineages. LET-60 RAS protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b signaling ZK809.5 Aff_ZK809.5 ZK809.5; 4M423; CE28874; CE33911; WBGene00014087; WP:CE28874; WP:CE33911 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK829.6 Aff_ZK829.6 tgt-1; ZK829.6; 4M722; CE06654; NM_069867; WBGene00006566; WP:CE06654; tgt tgt-1 encodes a tRNA-guanine transglycosylase predicted to be mitochondrial. queuine tRNA-ribosyltransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK856.11 Aff_ZK856.11 ZK856.11; 5K684; CE06668; WBGene00014112; WP:CE06668 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK858.7 Aff_ZK858.7 ZK858.7; 1J718; CE35204; WBGene00014120; WP:CE35204 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK899.8 Aff_C07B5.1 GAP-2-4; gap-2; ZK899.8; ZK899.8i.1; ZK899.8i.2; CE23470; CE23471; CE23472; CE23473; CE23474; CE23475; CE28277; CE31677; CE39119; NM_077193; WBGene00001516; WP:CE23470; WP:CE23471; WP:CE23472; WP:CE23473; WP:CE23474; WP:CE23475; WP:CE28277; WP:CE31677; WP:CE39119; XK133 gap-2 encodes a Ras GTPase-activating protein (RasGAP) that is orthologous to mammalian nGAP and synGAP (OMIM:606136, OMIM:603384, synGAP is essential for postnatal survival and neuronal development); by homology, GAP-2 is predicted to function as a negative regulator of Ras signaling by enhancing the intrinsically weak Ras GTPase activity; gap-2 loss-of-function mutations partially suppress the larval lethality of let-23 and let-60 loss-of-function mutations, supporting a role for gap-2 in negative regulation of Ras signaling in vivo; gap-2 can encode at least eight different isoforms that appear to be expressed in a wide variety of tissues including the vulva, gonad, pharynx, neurons, and blast/rectal cells of the tail. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK970.4 Aff_ZK970.4 vha-9; ZK970.4; ZK970.4.1; ZK970.4.2; 2K592; CE02404; NM_063816; WBGene00006918; WP:CE02404 H+-transporting ATPase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated