Baugh et al 2003, class SE, 942 genes Gene list file name: Baugh2003_classSE.txt Type of gene identifier: Affymetrix custom chip Description: Baugh et al 2005, Supplymental Dataset, class SE Organism: Caenorhabditis elegans (nematode) Gene list type: Experimental Gene name Source Gene ID All gene names WormBase description WormBase CDS description Proteome description Member of lists (Publications) Other annotations AC3.3 Aff_AC3.3 abu-1; pqn-1; AC3.3; 5K858; CE05133; NM_073266; WBGene00000024; WP:CE05133 abu-1 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-1 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-1 may help protect the organism from damage by improperly folded nascent protein. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 Fig6A Resveratrol, ViswanathanM et al 2005 S2 daf-16 Resveratrol AC3.7 Aff_AC3.7 dod-15; ugt-1; AC3.7; 5K877; CE05137; NM_073270; WBGene00007072; WP:CE05137 UDP-glucuronosyltransferase Kwon et al 2004 T1 late-induction Ethanol-response, Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T1 xenobiotic induced UDP-gl, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated AFF_B0564.10 Aff_B0564.10 AFF_C09G5.8 Aff_C09G5.8 AFF_C10B5.2 Aff_C10B5.2 AFF_C13B9.1 Aff_C13B9.1 AFF_C25D7.10 Aff_C25D7.10 AFF_F08G12.6 Aff_F08G12.6 AFF_F11D11.9 Aff_F11D11.9 AFF_F17C11.1 Aff_F17C11.1 AFF_F21D9.6 Aff_F21D9.6 AFF_F39D8.2 Aff_F39D8.2 AFF_F40F12.2 Aff_F40F12.2 AFF_F49H12.C Aff_F49H12.C AFF_H20H17.1 Aff_H20H17.1 AFF_H24O09.C Aff_H24O09.C AFF_K08B12.3 Aff_K08B12.3 AFF_K08F11.6 Aff_K08F11.6 AFF_K09D9.D Aff_K09D9.D AFF_M03A1.3 Aff_M03A1.3 AFF_R05F9.12 Aff_R05F9.12 AFF_R11A5.5 Aff_R11A5.5 AFF_R52.10 Aff_R52.10 AFF_T08B6.1 Aff_T08B6.1 AFF_T08G5.7 Aff_T08G5.7 AFF_T21C12.4 Aff_T21C12.4 AFF_T23H2.6 Aff_T23H2.6 AFF_T28A11.14 Aff_T28A11.14 AFF_W02A2.E Aff_W02A2.E AFF_W09G12.3 Aff_W09G12.3 AFF_Y105C5.RR Aff_Y105C5.RR AFF_Y105E8A.P Aff_Y105E8A.P AFF_Y106G6H.10 Aff_Y106G6H.10 AFF_Y106G6H.10_G Aff_Y106G6H.10_G AFF_Y116F11.ZZ17 Aff_Y116F11.ZZ17 AFF_Y119D3_465.L Aff_Y119D3_465.L AFF_Y13C8_223.B Aff_Y13C8_223.B AFF_Y17G9B.D Aff_Y17G9B.D AFF_Y2C2_202.A Aff_Y2C2_202.A AFF_Y40B10A_112.B Aff_Y40B10A_112.B AFF_Y41E3.5 Aff_Y41E3.5 AFF_Y45F10A.3 Aff_Y45F10A.3 AFF_Y47D3A.O Aff_Y47D3A.O AFF_Y49F6A_1689.C Aff_Y49F6A_1689.C AFF_Y50D7_162.A Aff_Y50D7_162.A AFF_Y52B11C.1 Aff_Y52B11C.1 AFF_Y54C5B.1 Aff_Y54C5B.1 AFF_Y55B1B_119.G Aff_Y55B1B_119.G AFF_Y56A3A.W Aff_Y56A3A.W AFF_Y71A12B.A Aff_Y71A12B.A AFF_Y71F9A_262.A Aff_Y71F9A_262.A B0024.14 Aff_B0024.14 crm-1; B0024.14; B0024.14c.1; B0024.14c.2; 5K804; CE31276; CE31277; CE31278; CE31279; CE36907; NM_171529; NM_171530; NM_171531; NM_171935; WBGene00007103; WP:CE31276; WP:CE31277; WP:CE31278; WP:CE31279; WP:CE36907 pro-collagen domains ViswanathanM et al 2005 S2 daf-16 Resveratrol B0207.12 Aff_B0207.12 avr-14; gbr-2; B0207.12; 1G544; CE26421; CE30227; CE32092; WBGene00000232; WP:CE26421; WP:CE30227; WP:CE32092 avr-14 encodes an alpha-type subunit of a glutamate-gated chloride channel homologous to human GLRA2, which when mutated leads to hyperekplexia (OMIM:149400); AVR-14 affects sensitivity to the antiparisitic drug, ivermectin, in parallel with avr-15 and glc-1 and in a genetic pathway with unc-9; it functions in the extrapharyngeal nervous system, and is expressed in a subset of neurons in the ring ganglia, ventral cord, and some mechanosensory neurons. B0213.6 Aff_B0213.6 nlp-31; B0213.6; 5E459; CE16777; NM_071706; WBGene00003769; WP:CE16777 nlp-31 encodes five predicted neuropeptide-like proteins; in C. elegans, nlp-31 is part of the YGGWamide neuropeptide family that also contains nlp-24, nlp-25, and nlp-27-32; nlp-31 is expressed in the hypodermis, suggesting that the peptides it encodes may have a non-neuronal function; nlp-31 expression is also detected in precomma-stage embryos; as loss of nlp-31 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of the nlp-31-encoded peptides in development and/or behavior is not yet known. Lund et al 2002 Fig4 Mount 15, Reinke et al 2004, IVb male soma enriched genes B0218.3 Aff_B0218.3 pmk-1; B0218.3; 4I913; CE06686; NM_068964; WBGene00004055; WP:CE06686 pmk-1 encodes a mitogen-activated protein kinase (MAPK), orthologous to human p38 MAPK (OMIM:600289), that is required for eliciting gonadal programmed cell death in response to Salmonella enterica infection; PMK-1 lies upstream of CED-9, a negative regulator of apoptosis, in the programmed cell death pathway. ser/thr kinases McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0228.6 Aff_B0228.6 B0228.6; 2I44; CE31283; WBGene00015063; WP:CE31283 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0238.1 Aff_B0238.1 B0238.1; 5F718; CE07691; WBGene00015067; WP:CE07691 carboxylesterase Murphy et al 2003 Fig2 Class1 elongate lifespan, ReichertK et al 2005 T1 B0250.9 Aff_B0250.9 B0250.9; 5U950; CE36579; WBGene00007126; WP:CE36579 B0250.9 is orthologous to the human gene 7-DEHYDROCHOLESTEROL REDUCTASE (DHCR7; OMIM:602858), which when mutated leads to disease. sterol reductase Lund et al 2002 Fig1 aging-regulated genes, McCarroll et al 2004 SFig5 conserved w/ yeast B0252.2 Aff_B0252.2 asm-1; B0252.2; 2H201; CE30230; NM_063014; WBGene00000211; WP:CE30230 Spingomyelin phosphodiesterase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated B0272.1 Aff_B0272.1 tbb-4; B0272.1; CE00850; NM_077184; WBGene00006538; WP:CE00850; XK54 tubulin beta chain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Portman et al 2004 T1 newly found ray-genes in25c, Portman et al 2004 T1 25 candidate ray genes, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated B0272.4 Aff_B0272.4 B0272.4; CE00853; WBGene00007130; WP:CE00853; XK47 enoyl-CoA hydratase/isomerase B0285.7 Aff_B0285.7 B0285.7; 3F453; CE00646; WBGene00007139; WP:CE00646 Aminopeptidase Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0285.8 Aff_B0285.8 ckb-1; B0285.8; 3F455; CE33590; NM_065478; WBGene00000511; WP:CE33590 choline kinase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0286.4 Aff_B0286.4 ntl-2; B0286.4; B0286.4a.1; B0286.4a.2; B0286.4c.1; B0286.4c.2; B0286.4c.3; B0286.4d.1; B0286.4d.2; B0286.4d.3; B0286.4d.4; B0286.4d.5; 2E664; CE03864; CE29537; CE29538; CE39662; NM_062371; NM_062372; NM_062373; WBGene00003825; WP:CE03864; WP:CE29537; WP:CE29538; WP:CE39662 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0303.14 Aff_B0303.14 B0303.14; 3J804; CE00003; WBGene00015132; WP:CE00003 Giant secretory protein I-C ViswanathanM et al 2005 S2 sir-2.1 regulated B0303.2 Aff_B0303.2 B0303.2; 3J775; CE00536; WBGene00015124; WP:CE00536 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 B0303.8 Aff_B0303.8 sdz-1; B0303.8; 3J788; CE00001; WBGene00015129; WP:CE00001 Romagnolo et al 2002 Fig3b Unkown B0310.2 Aff_B0310.2 B0310.2; B0310.2.1; B0310.2.2; CE03875; WBGene00015138; WP:CE03875; XB120 C2H2-type zinc fingers B0310.4 Aff_B0310.4 B0310.4; CE03877; WBGene00015140; WP:CE03877; XB132 repetitive proline-rich cell wall protein B0391.9 Aff_B0391.9 B0391.9; 5Q70; CE17337; WBGene00007164; WP:CE17337 B0462.3 Aff_B0462.3 fbxb-119; B0462.3; 5S797; CE15556; WBGene00007182; WP:CE15556 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol B0464.5 Aff_B0464.5 rsk-1; spk-1; srk-1; B0464.5; B0464.5b.1; B0464.5b.2; B0464.5c.1; B0464.5c.2; 3K551; CE20457; CE36373; CE36580; NM_066679; WBGene00004980; WP:CE20457; WP:CE36373; WP:CE36580 spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). Eukaryotic protein kinase domain ViswanathanM et al 2005 S2 sir-2.1 regulated B0491.1 Aff_B0491.1 B0491.1; 2L639; CE02103; WBGene00007189; WP:CE02103 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated B0507.1 Aff_B0507.1 B0507.1; 5J259; CE28815; WBGene00015218; WP:CE28815 Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 B0563.1 Aff_B0563.1 B0563.1; CE02439; WBGene00015261; WP:CE02439; XJ787 B0563.8 Aff_B0563.8 B0563.8; CE39467; WBGene00015265; WP:CE39467; XJ788 C01B12.2 Aff_C01B12.2 C01B12.2; 2A311; CE39124; WBGene00015285; WP:CE39124 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C01F1.3 Aff_C01F1.3 phi-41; C01F1.3; C01F1.3a.1; C01F1.3a.2; 2E587; CE06744; CE39553; WBGene00015298; WP:CE06744; WP:CE39553 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig3b Metabolism, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C01F4.2 Aff_F57C9.8 C01F4.2; 1F420; CE30414; CE33358; WBGene00015303; WP:CE30414; WP:CE33358 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C01G10.9 Aff_C01G10.9 C01G10.9; 5P563; CE07818; WBGene00007236; WP:CE07818 Initiation factor 2 subunit McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C01G8.9 Aff_C01G8.7 C01G8.9; 1F870; CE30415; CE33359; WBGene00015314; WP:CE30415; WP:CE33359 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C02B8.2 Aff_C02B8.2 C02B8.2; CE03891; WBGene00015321; WP:CE03891; XI761 C02B8.6 Aff_C02B8.6 C02B8.6; CE29656; WBGene00015324; WP:CE29656; XI752 DNA repair protein RAD16 (yeast, weak) ViswanathanM et al 2005 S2 sir-2.1 regulated C02D5.2 Aff_C02D5.2 C02D5.2; 3J647; CE00034; CE39554; WBGene00015336; WP:CE00034; WP:CE39554 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C02F12.1 Aff_C02F12.1 tsp-17; C02F12.1; CE35213; NM_076233; WBGene00006643; WP:CE35213; XE303 transpanin C02F12.7 Aff_C02F12.7 tag-278; C02F12.7; CE03901; WBGene00015356; WP:CE03901; XE304 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C05A9.2 Aff_C05A9.2 C05A9.2; CE05222; WBGene00007317; WP:CE05222; XL460 Jones et al 2001 Non dauer genes P<0.05 C05B5.4 Aff_C05B5.4 C05B5.4; 3L81; CE00880; WBGene00007321; WP:CE00880 ViswanathanM et al 2005 S2 sir-2.1 regulated C05B5.8 Aff_C05B5.6 C05B5.8; 3L96; CE33967; WBGene00007324; WP:CE33967 C05C8.3 Aff_C05C8.3 dao-1; fkb-3; C05C8.3; 5H707; CE07921; NM_072434; WBGene00001428; WP:CE07921 fkb-3 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506 immunosuppressant-binding protein 9; FKB-3 expression is positively regulated by signaling through the DAF-2 insulin receptor-like pathway and the activity of the DAF-16 fork-head transcription factor suggesting that FKB-3 could play a role in metabolism and longevity; however, as loss of FKB-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of FKB-3 in C. elegans development and/or behavior is not yet known; FKB-3 contains a predicted endoplasmic reticulum (ER) retention sequence and is thus proposed to localize to the ER. FKBP-binding protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C05D10.3 Aff_C05D10.3 C05D10.3; 3H174; CE29170; WBGene00015479; WP:CE29170 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C05D11.13 Aff_C05D11.13 C05D11.13; 3H532; CE03930; WBGene00015488; WP:CE03930 ViswanathanM et al 2005 S2 sir-2.1 regulated C05D11.5 Aff_C05D11.5 C05D11.5; 3H496; CE01135; WBGene00015483; WP:CE01135 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C05D11.7 Aff_C05D11.7 C05D11.7; C05D11.7a.1; C05D11.7a.2; 3H506; CE29663; CE30480; WBGene00015484; WP:CE29663; WP:CE30480 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order C05D12.4 Aff_C05D12.4 C05D12.4; 2L721; CE02972; WBGene00007341; WP:CE02972 Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C05D12.5 Aff_C05D12.5 C05D12.5; 2L723; CE02973; WBGene00007342; WP:CE02973 ViswanathanM et al 2005 S2 sir-2.1 regulated C05D9.3 Aff_C05D9.3 C05D9.3; CE35381; WBGene00015472; WP:CE35381; XB733 C05E4.1 Aff_C05E4.1 pes-21; C05E4.1; 5B243; CE07935; NM_070917; WBGene00005643; WP:CE07935 srp-2 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily that is orthologous to human NEUROSERPIN (OMIM:602445, mutated in familial encephalopathy with neuroserpin inclusion bodies); SRP-2 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases, and in vitro, recombinant SRP-2 is able to inhibit granzyme B activity; however, as loss of srp-2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-2 in C. elegans development and/or behavior is not yet known; srp-2 expression is detected in hypodermal cells, particularly in the lateral seam cells. serine protease inhibitor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S6 removed genes of contamination C05E4.9 Aff_H24O09.A gei-7; C05E4.9; C05E4.9a.1; C05E4.9a.2; C05E4.9a.3; C05E4.9b.1; C05E4.9b.2; 5B204; CE23521; CE32565; NM_070905; WBGene00001564; WP:CE23521; WP:CE32565 gei-7 encodes a predicted isocitrate lyase/malate synthase, an enzyme known to function in the glyoxylate cycle; GEI-7 was identified in a screen for proteins that interact with GEX-3, a homolog of human HEM-2 which is required for embryonic development; GEI-7 is required for embryonic morphogenesis and appears to act downstream of DAF-16 to influence lifespan. McCarroll et al 2004 SFig5 conserved w/ yeast, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated C05G5.3 Aff_C05G5.3 C05G5.3; CE30853; WBGene00007349; WP:CE30853; XP370 C06B8.7 Aff_C06B8.7 C06B8.7; 5P989; CE30854; WBGene00007372; WP:CE30854 Human M130 antigen like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated C06C3.1 Aff_C06C3.1 mel-11; C06C3.1; 2J657; CE20486; CE32566; CE32567; CE36682; NM_063593; WBGene00003196; WP:CE20486; WP:CE32566; WP:CE32567; WP:CE36682 ankyrin-like repeats McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order C06E1.10 Aff_C06E1.10 rha-2; C06E1.10; 3J700; CE29563; WBGene00015525; WP:CE29563 The C06E1.10 gene encodes a DEAH helicase orthologous to the Drosophila KURZ, the human KIAA1517, and the S. cerevisiae ECM16 proteins. ATP-dependent RNA helicase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C06G4.2 Aff_C06G4.2 clp-1; C06G4.2; C06G4.2a.1; C06G4.2a.2; C06G4.2b.1; C06G4.2b.2; C06G4.2b.3; 3J75; CE00517; CE30486; CE37743; CE37744; NM_066339; NM_066340; NM_171201; NM_171886; WBGene00000542; WP:CE00517; WP:CE30486; WP:CE37743; WP:CE37744 clp-1 encodes a calpain homolog that has significant identity to mammalian calpains over its whole length and that contains motifs typical of calpains, including a thiol (cysteine) protease active site and a Ca[2+]-binding domain; CLP-1 is required, in parallel with TRA-3 but in series with ASP-3 and ASP-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C06G8.1 Aff_C06G8.1 C06G8.1; 4L544; CE05229; WBGene00007384; WP:CE05229 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C07A9.6 Aff_C07A9.6 ugt-60; C07A9.6; C07A9.6.1; C07A9.6.2; 3K766; CE33970; WBGene00007402; WP:CE33970 UDP-glucuronosyltransferase C07B5.5 Aff_C07B5.5 nuc-1; C07B5.5; CE00895; NM_077203; WBGene00003828; WP:CE00895; XK159 The nuc-1 gene encodes a DNase II homolog similar to mammalian and Drosophila DNaseII enzymes and is required for DNA degradation during apoptosis as well as for degradation of dietary DNA during normal feeding; during apoptosis, NUC-1 functions in apoptotic cells at an intermediate stage of DNA degradation, after the killing step, but prior to cell-corpse engulfment. Golden et al 2004, daf-2 differentially expressed , McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C08B11.3 Aff_C08B11.3 C08B11.3; 2I314; CE01473; WBGene00007433; WP:CE01473 Zinc finger, C2H2 type McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated C08F1.3 Aff_C08F1.3 fbxb-13; C08F1.3; 2C79; CE08018; WBGene00015607; WP:CE08018 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. C08F1.6 Aff_C08F1.6 C08F1.6; 2C78; CE08021; WBGene00015610; WP:CE08021 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol C08F1.8 Aff_C08F1.8 C08F1.8; 2C92; CE08023; WBGene00015611; WP:CE08023 reverse transcriptase ViswanathanM et al 2005 S2 daf-16 Resveratrol C08F8.4 Aff_C08F8.4 C08F8.4; 4L922; CE05251; WBGene00007446; WP:CE05251 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm C08F8.5 Aff_C08F8.5 fbxb-9; C08F8.5; 4L924; CE05252; WBGene00007447; WP:CE05252 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol C08F8.8 Aff_C08F8.8 nhr-67; C08F8.8; 4L939; CE18491; NM_069693; WBGene00003657; WP:CE18491 nuclear hormone receptor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C09B8.4 Aff_C09B8.4 C09B8.4; CE30242; WBGene00015623; WP:CE30242; XG638 ViswanathanM et al 2005 S2 sir-2.1 regulated C09B9.1 Aff_C09B9.1 C09B9.1; 4F805; CE06793; WBGene00015626; WP:CE06793 Jones et al 2001 Dauer specific genes P<0.05, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit C09D4.2 Aff_C09D4.2 C09D4.2; 1G59; CE08031; WBGene00015633; WP:CE08031 Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C09G5.4 Aff_C09G5.4 col-39; C09G5.4; 2K995; CE01484; NM_063908; WBGene00000616; WP:CE01484 col-39 encodes a collagen that is individually dispensable for viability and gross morphology in mass RNAi screens; the amino- and carboxyl-terminal cysteine-rich regions of COL-39 are most closely related to those of COL-8, COL-19, and COL-35. collagen Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C09H6.2 Aff_C09H6.2 lin-10; C09H6.2; 1I686; CE15610; CE27060; NM_059825; WBGene00002999; WP:CE15610; WP:CE27060 The lin-10 gene encodes a PDZ and PTB domain-containing protein that is homologous to mammalian Munc interacting proteins (Mint1, OMIM:602414) and is required for polarized protein localization; LIN-10 is required for proper localization of the LET-23 EGF receptor to the basolateral membrane of the vulval precursor cells and for proper postsynaptic localization of GLR-1, an AMPA-type glutamate receptor in interneurons; LIN-10 is detected in the cytoplasm, membrane, and at particularly high levels in the Golgi. Phosphotyrosine interaction domain (PTB/PID)., PDZ domain (Also known as DHR or GLGF). (2 domains) C10A4.3 Aff_C10A4.3 C10A4.3; CE02471; WBGene00015664; WP:CE02471; XI19 ViswanathanM et al 2005 S2 sir-2.1 regulated C10C5.3 Aff_C10C5.3 C10C5.3; 4K139; CE03011; WBGene00007507; WP:CE03011 aminoacylase-1 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated C10C5.5 Aff_C10C5.5 C10C5.5; 4K147; CE36099; WBGene00007509; WP:CE36099 aminoacylase-1 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C10C6.3 Aff_C10C6.3 C10C6.3; 4M226; CE35392; WBGene00007512; WP:CE35392 Reinke et al 2004, herm sperm, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes C10E2.4 Aff_C10E2.4 C10E2.4; CE08063; WBGene00015674; WP:CE08063; XR360 C10F3.4 Aff_C10F3.4 C10F3.4; 5G449; CE30723; CE37609; WBGene00015678; WP:CE30723; WP:CE37609 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C10G8.6 Aff_C10G8.6 ceh-34; C10G8.6; 5F794; CE20496; NM_072018; WBGene00000455; WP:CE20496 ceh-34 encodes a homeodomain protein, homologous to human SIX2 (OMIM:604994), that is expressed very weakly in the pharynxes of late embryos and early larvae; it has no known function. homeobox protein C10H11.3 Aff_C10H11.3 ugt-25; C10H11.3; 1F303; CE08092; WBGene00015692; WP:CE08092 7TM chemoreceptor, ugt family Kwon et al 2004 T1 late-induction Ethanol-response, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, fem3 enriched genes C11G6.2 Aff_C11G6.2 C11G6.2; CE05256; WBGene00007523; WP:CE05256; XQ943 helicase like C11G6.4 Aff_C11G6.4 nhr-28; C11G6.4; C11G6.4a.1; C11G6.4a.2; C11G6.4b.1; C11G6.4b.2; C11G6.4b.3; CE27061; CE37954; WBGene00003624; WP:CE27061; WP:CE37954; XQ973 nuclear hormone receptor, nhr-28 C11H1.7 Aff_C11H1.7 C11H1.7; CE18492; WBGene00007531; WP:CE18492; XO945 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C11H1.9 Aff_C11H1.5 C11H1.9; CE05264; CE37316; WBGene00023500; WP:CE05264; WP:CE37316; XO938 Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C13B7.5 Aff_Y45G12C.G str-119; C13B7.5; C13B7.A; 5C904; CE20503; NM_071265; WBGene00006170; WP:CE20503 7TM chemoreceptor, str family C13C12.2 Aff_C13C12.2 C13C12.2; 5N4; CE08133; WBGene00007552; WP:CE08133 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 C13G5.1 Aff_C13G5.1 ceh-16; C13G5.1; 3J715; CE37477; NM_066497; WBGene00000439; WP:CE37477 ceh-16 encodes a protein that contains a homeobox domain. Engrailed homeotic protein Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C14A4.6 Aff_C14A4.6 C14A4.6; C14A4.6.1; C14A4.6.2; 2K884; CE02147; WBGene00007557; WP:CE02147 C14B9.6 Aff_C14B9.5 gei-8; pqn-12; C14B9.6; 3J202; CE29577; CE30603; CE36784; NM_066371; NM_066372; NM_171207; WBGene00001565; WP:CE29577; WP:CE30603; WP:CE36784 gei-8 encodes a novel protein highly similar to C. briggsae BP:CBP04038 that contains a glutamine/asparagine (Q/N)-rich ('prion') domain (by the algorithm of Michelitsch and Weissman) and two myb-like DNA-binding domains; interacts with GEX-3 in yeast two-hybrid assays. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C14F11.2 Aff_C14F11.2 C14F11.2; CE29578; WBGene00015779; WP:CE29578; XG828 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order C14F11.6 Aff_C14F11.6 C14F11.6; CE02482; WBGene00015781; WP:CE02482; XG856 DTDP-4-dehydrorhamnose 3,5-epimerase (RFBC gene) Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C14H10.2 Aff_C14H10.2 C14H10.2; CE23543; WBGene00007592; WP:CE23543; XK862 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C15C8.1 Aff_C15C8.1 C15C8.1; 5N215; CE05285; WBGene00007604; WP:CE05285 ViswanathanM et al 2005 S2 daf-16 Resveratrol C15H9.10 Aff_C15H9.10 C15H9.10; CE06836; WBGene00015804; WP:CE06836; XG730 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated C15H9.7 Aff_C15H9.7 C15H9.7; CE06835; WBGene00015802; WP:CE06835; XG726 kynureninase McCarroll et al 2004 SFig5 conserved w/ yeast, Murphy et al 2003 Fig2 Class2 shorten lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C15H9.8 Aff_C15H9.8 prx-3; C15H9.8; CE04000; NM_076624; WBGene00004193; WP:CE04000; XG732 prx-3 is orthologous to the human gene PEROXISOMAL BIOGENESIS FACTOR 3 (PEX3; OMIM:603164), which when mutated leads to Zellweger syndrome of complementation group G. ViswanathanM et al 2005 S2 sir-2.1 regulated C16C4.6 Aff_C16C4.6 fbxb-98; C16C4.6; 2C131; CE08202; WBGene00015830; WP:CE08202 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 daf-16 Resveratrol C16H3.3 Aff_C16H3.3 C16H3.3; CE08237; CE27697; WBGene00015868; WP:CE08237; WP:CE27697; XS216 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol C17B7.3 Aff_C17B7.3 C17B7.3; 5D823; CE16851; WBGene00015877; WP:CE16851 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C17C3.12 Aff_C17C3.12 acdh-2; C17C3.12; C17C3.12c.1; C17C3.12c.2; CE29175; CE29176; CE34697; NM_062665; NM_062666; NM_062667; WBGene00015894; WP:CE29175; WP:CE29176; WP:CE34697 acyl-CoA dehydrogenase ViswanathanM et al 2005 S2 sir-2.1 regulated C17C3.7 Aff_C17C3.7 hlh-25; C17C3.7; 2F825; CE04027; NM_062662; WBGene00001964; WP:CE04027 C17C3.8 Aff_C17C3.8 hlh-26; C17C3.8; 2F822; CE04028; NM_062661; WBGene00001965; WP:CE04028 C17D12.7 Aff_C17D12.7 C17D12.7; 1M196; CE23554; WBGene00007640; WP:CE23554 ViswanathanM et al 2005 S2 sir-2.1 regulated C17G1.3 Aff_C17G1.3 ugt-23; C17G1.3; CE08282; WBGene00007650; WP:CE08282; XK542 UDP-glucosyltransferase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C17G1.7 Aff_C17G1.7 C17G1.7; C17G1.7.1; C17G1.7.2; CE39223; WBGene00007653; WP:CE39223; XK572 cysteine synthase Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order C18A11.7 Aff_C18A11.7 dim-1; C18A11.7; C18A11.7b.1; C18A11.7b.2; C18A11.7b.3; C18A11.7b.4; CE04038; CE27706; WBGene00001000; WP:CE04038; WP:CE27706; XI670 Link et al 2003 T2 Abeta repressed, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C C18D1.1 Aff_C18D1.1 die-1; C18D1.1; C18D1.1.1; C18D1.1.2; 2K352; CE01501; NM_063774; WBGene00000995; WP:CE01501 die-1 encodes a C2H2 zinc finger protein containing four fingers, homologous to CG18265-PA in Drosophila; DIE-1 is autonomously required in the posterior dorsal hypodermis for intercalation, for morphogenesis in other embryonic tissues, and for normal postembryonic growth and vulval development. Zinc finger, C2H2 type (3 domains) Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol C18D11.2 Aff_C18D11.2 maa-1; C18D11.2; 3M910; CE18513; NM_067130; WBGene00007680; WP:CE18513 maa-1 encodes a predicted membrane-associated Acyl-CoA binding protein; loss of maa-1 activity via RNAi results in no obvious defects. Acyl CoA binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C18G1.2 Aff_C18G1.2 C18G1.2; 5F251; CE17418; WBGene00015981; WP:CE17418 GATA transcription factor Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C23F12.1 Aff_B0272.5 C23F12.1; CE32133; CE32134; WBGene00016006; WP:CE32133; WP:CE32134; XK45 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B C23H4.6 Aff_C23H4.6 C23H4.6; CE08332; WBGene00007694; WP:CE08332; XM859 Yeast RAD18 protein like Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 daf-16 Resveratrol C24B5.4 Aff_C24B5.4 C24B5.4; 5J674; CE37611; WBGene00016046; WP:CE37611 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C24H11.2 Aff_C24H11.1 C24H11.2; 3M880; CE18525; WBGene00007700; WP:CE18525 Protein phosphatase-1 (PP1) Reinke et al 2004, male sperm, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, mixed sperm soma, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, GO categories C24H11.3 Aff_C24H11.3 tbx-38; C24H11.3; 3M874; CE18526; NM_067125; WBGene00006557; WP:CE18526 T-box Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories C25G6.2 Aff_C25G6.2 tsp-9; C25G6.2; CE04083; NM_075831; WBGene00006635; WP:CE04083; XB865 transpanin ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C25G6.5 Aff_C25G6.5 C25G6.5; CE04086; WBGene00016110; WP:CE04086; XB868 G-protein coupled receptor (family 1) Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C26B9.1 Aff_C26B9.1 C26B9.1; CE30880; CE34262; NM_076507; WBGene00016131; WP:CE30880; WP:CE34262 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C26G2.1 Aff_C26G2.1 syg-2; C26G2.1; CE19703; NM_078034; WBGene00007750; WP:CE19703; XP281 syg-2 encodes a transmembrane protein that is a member of the immunoglobulin superfamily of proteins; during larval development, SYG-2 activity is required in vulval epithelial cells for proper synaptic specificity of the HSNL neuron; in regulating synapse formation, SYG-2 acts as a guidepost protein for the SYG-1 receptor that interacts with SYG-2 and acts within HSNL to regulate synaptic specificity; a SYG-2::GFP fusion protein is expressed in the primary vulval cell lineages beginning at the L3 larval stage, with expression increasing during the L4 stage and finally disappearing by adulthood; in embryos, SYG-2::GFP expression is detected in some head neurons and body wall muscles, the latter of which also express the reporter during the L1 and L2 larval stages. Immunoglobulin domain ; Fibronectin type III domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C27C12.6 Aff_C27C12.6 dmd-4; C27C12.6; CE23560; WBGene00007776; WP:CE23560; XP476 doublesex protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C27C7.7 Aff_C27C7.7 C27C7.7; 1M11; CE18537; WBGene00007769; WP:CE18537 C27D8.3 Aff_C27D8.3 C27D8.3; 4N472; CE08422; CE39679; WBGene00007779; WP:CE08422; WP:CE39679 The C27D8.3 gene encodes a protein that may be involved in apoptosis. ViswanathanM et al 2005 S2 sir-2.1 regulated C28A5.4 Aff_C28A5.4 ceh-43; C28A5.4; 3F536; CE05325; NM_065503; WBGene00000463; WP:CE05325 A homeobox protein of the Distal-less (Dll) class that is required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability; it is predominantly expressed in the head hypdodermis, neuronal support cells and CAN neurons. homeobox protein (distal-less subfamily) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Portman et al 2004 T1 25 candidate ray genes, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C28C12.7 Aff_C28C12.7 spp-10; C28C12.7; C28C12.7a.1; C28C12.7a.2; 4J243; CE29486; CE31323; NM_171399; NM_171400; WBGene00004995; WP:CE29486; WP:CE31323 spp-10 encodes two protein isoforms that are orthologous to the human gene PROSAPOSIN (PSAP; OMIM:176801, mutated in Gaucher disease and metachromatic leukodystrophy); SPP-10A and -10B are predicted to have 3 and 4 embedded saposin sequences, that are likely to be split into individual saposin peptides by proteolysis; in mammals, saposins activate the enzymes sphingomyelinphosphodiesterase and beta-glucosylceramidase; spp-10 has no obvious function in mass RNAi assays. 7TM chemoreceptor, spp family Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C28G1.4 Aff_C28G1.4 C28G1.4; CE04121; WBGene00016189; WP:CE04121; XJ468 zinc finger C29E4.5 Aff_C29E4.5 tag-250; C29E4.5; 3J8; CE29682; CE38589; WBGene00016203; WP:CE29682; WP:CE38589 C29F7.2 Aff_C29F7.2 C29F7.2; CE35414; WBGene00007811; WP:CE35414; XO35 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes C29F7.6 Aff_C29F7.6 C29F7.6; CE08447; WBGene00007813; WP:CE08447; XO59 Romagnolo et al 2002 Fig3b others, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C30G4.3 Aff_C30G4.3 gcy-11; C30G4.3; CE39901; NM_078354; WBGene00001537; WP:CE39901; XR660 guanylate cyclase receptor Baugh et al 2005, PAL-1 target genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C31C9.1 Aff_C31C9.1 tag-10; C31C9.1; 2N925; CE32597; CE32598; WBGene00006404; WP:CE32597; WP:CE32598 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial Bishop et al 2004 T1 Upregulated in vhl-1 vs WT, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C31E10.6 Aff_C31E10.6 C31E10.6; CE08506; WBGene00007847; WP:CE08506; XO617 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C31H2.4 Aff_C31H2.4 C31H2.4; CE04132; WBGene00016294; WP:CE04132; XF772 C31H2.4 is orthologous to human 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE (HPD; OMIM:276710), which when mutated leads to tyrosinemia type III; C31H2.4 is somewhat less similar to human HPD than C. elegans HPD-1 (to which C31H2.4 is paralogous). Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated C32B5.14 Aff_C32B5.14 C32B5.14; 2B254; CE08522; WBGene00016307; WP:CE08522 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated C32B5.15 Aff_C32B5.15 C32B5.15; 2B258; CE08523; WBGene00016308; WP:CE08523 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. C32B5.16 Aff_C32B5.16 sdz-4; C32B5.16; 2B251; CE08524; WBGene00016309; WP:CE08524 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C32B5.5 Aff_C32B5.5 C32B5.5; 2B261; CE34725; WBGene00016298; WP:CE34725 C32B5.9 Aff_C32B5.9 C32B5.9; 2B247; CE08517; WBGene00016302; WP:CE08517 ViswanathanM et al 2005 S2 daf-16 Resveratrol C32E8.7 Aff_C32E8.7 ric-19; C32E8.7; 1E346; CE39089; NM_058815; WBGene00004368; WP:CE39089 The ric-19 gene encodes an evolutionarily conserved cytosolic protein involved in neuroendocrine secretion via association with secretory vesicles. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C33A12.12 Aff_C33A12.12 C33A12.12; 4K248; CE15665; WBGene00007887; WP:CE15665 Leucine Rich Repeat (2 copies) (2 domains) ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C33A12.2 Aff_C33A12.2 nlp-35; C33A12.2; 4K284; CE05348; WBGene00007881; WP:CE05348 C33B4.3 Aff_C33B4.3 tag-67; C33B4.3; 2L676; CE01508; CE36107; WBGene00006444; WP:CE01508; WP:CE36107 ankyrin and proline rich domains McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C33C12.5 Aff_C33C12.5 fbxb-38; C33C12.5; 2C458; CE08553; WBGene00016337; WP:CE08553 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes C33D12.7 Aff_C33D12.7 ceh-30; C33D12.7; CE06909; NM_076123; WBGene00000451; WP:CE06909; XD683 ceh-30 encodes a homeodomain protein most similar to Drosophila and mammalian BarH1 (OMIM:605211) which function in neuronal cell fate determination; the precise biological role of CEH-30 in C. elegans development and/or behavior is not yet known. homeobox protien McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C33D3.1 Aff_C33D3.1 elt-2; C33D3.1; CE31430; GATA; NM_077354; WBGene00001250; WP:CE31430; XL101 elt-2 encodes a GATA-type transcription factor most similar to the vertebrate GATA4-6 transcription factors required for cardiac and endoderm development (OMIM:601656, 600576); in C. elegans, ELT-2 is required redundantly with ELT-7 for initiating and maintaining terminal differentiation of the intestine; ELT-2 is expressed solely in the intestine, beginning embryonically at the 2E-cell stage and continuing in all intestinal cells throughout the life of the animal; in the regulatory hierarchy controlling endoderm development, ELT-2 lies downstream of the maternal regulators SKN-1 and POP-1 and the embryonic GATA factors MED-1/-2, and END-1/-3; in turn, ELT-2, along with ELT-7, likely regulates transcription of a number of intestine-specific terminal differentiation genes such as ges-1, ifb-2, pha-4, and the stress-induced mtl-2; ELT-2 also positively autoregulates, presumably to ensure maintenance of intestinal differentiation zinc finger protein (GATA type) C33D9.5 Aff_C33D9.5 C33D9.5; 4J544; CE37808; WBGene00007899; WP:CE37808 Yeast RAD50 like protein ViswanathanM et al 2005 S2 daf-16 Resveratrol C33D9.8 Aff_C33D9.8 C33D9.8; 4J548; CE03048; WBGene00007901; WP:CE03048 ViswanathanM et al 2005 S2 sir-2.1 regulated C33E10.1 Aff_C33E10.1 C33E10.1; CE34265; WBGene00016345; WP:CE34265; XR919 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C33F10.7 Aff_C33F10.7 C33F10.7; C33F10.7b.1; C33F10.7b.2; 2F108; CE04140; CE37751; WBGene00016355; WP:CE04140; WP:CE37751 esterase and beta-lactamase Kwon et al 2004 T1 late-induction Ethanol-response, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C34C6.6 Aff_C34C6.6 PEX-5; prx-5; C34C6.6; 2I995; CE03054; CE36377; WBGene00004194; WP:CE03054; WP:CE36377 prx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B C34E11.1 Aff_C34E11.1 rsd-3; C34E11.1; C34E11.1.1; C34E11.1.2; CE03062; NM_077572; WBGene00004682; WP:CE03062; XM421 yeast hypothetical L8167.6 like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C34G6.4 Aff_C34G6.4 pgp-2; C34G6.4; 1G471; CE29212; NM_059306; WBGene00003996; WP:CE29212 pgp-2 encodes a member of the ABC transporter family with highest similarity to the vertebrate MDR (multidrug resistance) family, and is orthologous to human MDR1 (ABCB1; OMIM:171050, mutated in Crohn disease); PGP-2 is expressed at lower levels during the embryonic stages with higher expression later in development. abc transporter McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C C34G6.6 Aff_C34G6.6 noah-1; C34G6.6; C34G6.6a.1; C34G6.6a.2; 1G452; CE29699; CE30432; WBGene00016422; WP:CE29699; WP:CE30432 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 C34H3.2 Aff_C34H3.A odd-2; C34H3.2; CE23571; NM_076631; WBGene00003846; WP:CE23571; XG778 odd-2 encodes a protein with homology to the Drosophila ODD-SKIPPED family members and affects larval viability; expressed in the intestine. C2H2-type zinc finger protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Romagnolo et al 2002 Fig3b TF C35C5.1 Aff_C35C5.1 sdc-2; C35C5.1; CE18542; NM_077523; WBGene00004746; WP:CE18542; XM151 The sdc-2 gene encodes a protein that represses transcription of X chromosomes to achieve dosage compensation, and that also represses the male sex-determination gene her-1 to elicit hermaphrodite differentiation. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C35D10.8 Aff_C35D10.8 C35D10.8; 3F945; CE29702; WBGene00016445; WP:CE29702 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order C35D6.3 Aff_C35D6.3 C35D6.3; 4R99; CE15682; WBGene00007960; WP:CE15682 ViswanathanM et al 2005 S2 sir-2.1 regulated C35E7.3 Aff_C35E7.3 C35E7.3; 1L415; CE17516; WBGene00016455; WP:CE17516 Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated C35E7.5 Aff_C35E7.5 C35E7.5; 1L403; CE17518; CE32817; WBGene00016457; WP:CE17518; WP:CE32817 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C36E8.3 Aff_C36E8.3 C36E8.3; 3F99; CE30889; WBGene00007982; WP:CE30889 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol C36F7.1 Aff_C36F7.1 irx-1; C36F7.1; 1K114; CE17526; WBGene00007984; WP:CE17526 Homeobox domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C37E2.4 Aff_C37E2.4 ceh-36; C37E2.4; CE08623; NM_077964; WBGene00000457; WP:CE08623; XO802 ceh-36 encodes a paired-like homeodomain transcription factor that is one of three orthodenticle (OTD)-like homeodomain proteins in C. elegans (the others being ttx-1 and ceh-37); CEH-36 is required broadly for specification of the AWC olfactory neuron and also for establishing the left-right asymmetry of the ASEL and ASER gustatory neurons; in addition, CEH-36 is sufficient to specify the AFD thermosensory neuron fate in some cell types; CEH-36 is expressed in the AWC and ASE chemosensory neurons. Homeobox domain C37E2.5 Aff_C37E2.5 ceh-37; C37E2.5; CE08624; NM_077965; WBGene00000458; WP:CE08624; XO816 ceh-37 encodes one of three C. elegans proteins with an OTX-like homeodomain; however, CEH-37 lacks other domains found in OTX proteins, and the CEH-37 homeodomain is predicted to resemble the Myb domain of telomere-binding proteins; CEH-37 binds the telomeric sequence 'TTAGGC' if it is repeated at least 1.5 times, and is mainly localized to the telomere in vivo; ceh-37 mutants have a weak increase in chromosomal nondisjunction; CEH-37 is involved in specifying some aspects of the AWB olfactory neuron fate, such as expression of an AWB-specific odorant receptor and a LIM-class homeodomain protein, LIM-4; CEH-37 is expressed broadly in the early embryo, while in larvae and adults it is expressed solely in the excretory cell. Homeobox domain ViswanathanM et al 2005 S2 sir-2.1 regulated C38C6.4 Aff_C38C6.4 sre-13; C38C6.4; 2O918; CE38042; NM_064641; WBGene00007997; WP:CE38042 7TM receptor, sre family C39B5.2 Aff_C39B5.C C39B5.2; 3D325; CE23578; WBGene00016520; WP:CE23578 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, herm soma enriched genes C39E6.4 Aff_C39E6.3 mls-2; C39E6.4; CE30891; NM_076414; WBGene00003377; WP:CE30891; XF378 C39F7.2 Aff_C39F7.2 C39F7.2; C39F7.2.1; C39F7.2.2; 5B704; CE27581; WBGene00016539; WP:CE27581 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C40A11.2 Aff_C40A11.2 C40A11.2; C40A11.2.1; C40A11.2.2; 2C437; CE34742; WBGene00016545; WP:CE34742 C40A11.3 Aff_C40A11.3 C40A11.3; 2C433; CE19366; WBGene00016546; WP:CE19366 Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated C40A11.4 Aff_C40A11.4 C40A11.4; 2C429; CE36797; WBGene00016547; WP:CE36797 C40A11.7 Aff_C40A11.7 C40A11.7; 2C438; CE19370; WBGene00016550; WP:CE19370 C41D11.1 Aff_C41D11.1 C41D11.1; 1F33; CE08658; WBGene00016561; WP:CE08658 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C41H7.1 Aff_C41H7.1 C41H7.1; 2D307; CE32605; WBGene00016571; WP:CE32605 C43D7.2 Aff_C43D7.2 fbxb-65; C43D7.2; 5T805; CE18547; WBGene00008066; WP:CE18547 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C43D7.8 Aff_Y116F11.I C43D7.8; 5T784; CE18552; WBGene00008070; WP:CE18552 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 daf-16 Resveratrol C44B7.9 Aff_C44B7.9 pmp-2; C44B7.9; 2H174; CE02547; NM_063007; WBGene00004059; WP:CE02547 peroxisomal membrane protein (PMP70, an ATP-binding transport protein) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C44C10.1 Aff_C44C10.1 col-180; C44C10.1; CE05408; NM_077559; WBGene00000753; WP:CE05408; XM332 collagen Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C44C8.1 Aff_C44C8.1 C44C8.1; 4B655; CE17541; WBGene00016646; WP:CE17541 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C44C8.2 Aff_C44C8.2 C44C8.2; 4B653; CE17542; WBGene00016647; WP:CE17542 Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C44H4.2 Aff_C44H4.2 sym-5; C44H4.2; CE08723; NM_078024; WBGene00006370; WP:CE08723; XP197 sym-5 encodes a predicted transmembrane protein that contains 13 contiguous leucine-rich repeats (LRRs) and that is similar to SYM-1, a secreted protein involved in muscle attachment; sym-5 activity appears to be required for embryogenesis and functionally overlaps with that of sym-1 and mec-8 in affecting muscle attachment; in addition, loss of sym-5 activity via RNA-mediated interference (RNAi) in a hypersensitized strain indicates that SYM-5 may also be required for locomotion, body morphology, and normal rates of postembryonic growth. Drosophila chaoptin protein like Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 C44H4.3 Aff_C44H4.3 sym-1; C44H4.3; CE08724; NM_078025; WBGene00006366; WP:CE08724; XP201 sym-1 encodes a protein containing 15 contiguous leucine-rich repeats (LRRs) that functionally overlaps with sym-5 and interacts with mec-8 with respect to embryonic viability and attachment of body muscle to the extracellular cuticle; expression begins at the time of embryonic elongation and SYM-1 is secreted from the apical hypodermal surface of the embryo Drosophila chaoptin protein like Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 C45B11.3 Aff_C45B11.3 dhs-18; C45B11.3; C45B11.3.1; C45B11.3.2; 5L526; CE05427; NM_073411; WBGene00000981; WP:CE05427 alcohol dehydrogenase Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order C45E1.1 Aff_C45E1.1 nhr-64; C45E1.1; 1D677; CE39696; CE39697; WBGene00003654; WP:CE39696; WP:CE39697 nhr-64 encodes a conserved nuclear receptor that is a member of the NR2 subfamily of nuclear receptors that contains Drosophila and human HNF4 (OMIM:600281, mutations in human HNF4A are associated with Type I MODY (maturity-onset diabetes of the young)); by homology, NHR-64 is predicted to function as a transcription factor that may activate or repress transcription in response to a hormonal signal; however, as loss of nhr-64 activity via RNAi does not result in any obvious abnormalities, the precise role of NHR-64 in C. elegans development and/or behavior is not yet known; nhr-64 is broadly expressed and detected in anterior and posterior neurons, the ventral nerve cord, the pharynx, gut, and hypodermis. Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S8 SAGE genes in the dauer exit C45G9.11 Aff_C45G9.11 C45G9.11; 3G154; CE27856; WBGene00016682; WP:CE27856 C46C11.2 Aff_C46C11.2 C46C11.2; CE39005; CE39006; WBGene00016705; WP:CE39005; WP:CE39006; XF253 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph C46G7.1 Aff_C46G7.1 C46G7.1; C46G7.1.1; C46G7.1.2; 4G783; CE37213; WBGene00016721; WP:CE37213 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B C46H11.9 Aff_C46H11.9 phat-2; C46H11.9; 1F614; CE08791; WBGene00016733; WP:CE08791 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 C47C12.3 Aff_C47C12.3 C47C12.3; C47C12.3a.1; C47C12.3a.2; CE33037; CE35437; NM_076907; WBGene00004335; WP:CE33037; WP:CE35437; XI361 ref-2 is orthologous to the human gene ZINC FINGER PROTEIN OF CEREBELLUM ZIC2 (ZIC2; OMIM:603073), which when mutated leads to disease. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C47D12.4 Aff_C47D12.4 C47D12.4; 2L969; CE20568; WBGene00008138; WP:CE20568 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol C47E12.8 Aff_C47E12.8 CeCRMP/DHP-2; dhp-2; C47E12.8; 4K745; CE05452; NM_069396; WBGene00000964; WP:CE05452 The dhp-2 gene encodes an ortholog of the human gene DIHYDROPYRIMIDINASE (DPYS), which when mutated leads to dihydropyrimidinuria (OMIM:222748). Ulip like protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C47F8.1 Aff_C47F8.1 C47F8.1; 1M929; CE17570; WBGene00008157; WP:CE17570 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated C47G2.2 Aff_C47G2.2 unc-130; C47G2.2; 2L573; CE02166; NM_064010; WBGene00006853; WP:CE02166 A member of the forkhead domain family of transcription factors that affects the generation of the AWA and ASG chemosensory neurons and is partially required for male tail morphogenesis and embryogenesis; it is expressed in the AWA and ASG precursors; it is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor. fork head domain protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated C48D1.1 Aff_C48D1.1 C48D1.1; 4N958; CE32833; CE39701; WBGene00008177; WP:CE32833; WP:CE39701 C.elegans ZYG-11 like protein Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes C48E7.1 Aff_C48E7.1 C48E7.1; 1G839; CE08816; WBGene00016749; WP:CE08816 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA C49A1.4 Aff_C49A1.4 eya-1; C49A1.4; C49A1.4b.1; C49A1.4b.2; 1O814; CE15722; CE36113; WBGene00001377; WP:CE15722; WP:CE36113 eya-1 encodes a protein orthologous to Drosophila EYES ABSENT (EYA), human EYA1, and human EYA4; the human genes EYA1 and EYA4, when mutated, lead to branchiootorenal dysplasia syndrome (BOR; OMIM:113650) and autosomal dominant nonsyndromic sensorineural (late-onset) deafness (DFNA10; OMIM:601316). McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C50A2.4 Aff_C50A2.4 C50A2.4; 4B908; CE17582; WBGene00016798; WP:CE17582 C50B6.9 Aff_C50B6.9 C50B6.9; 5N819; CE08878; WBGene00008222; WP:CE08878 C50E10.4 Aff_C50E10.4 sop-2; C50E10.4; 2M633; CE32334; NM_064220; WBGene00004945; WP:CE32334 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C50F2.1 Aff_C50F2.1 C50F2.1; 1E461; CE36635; WBGene00016835; WP:CE36635 ViswanathanM et al 2005 S2 sir-2.1 regulated C50F2.4 Aff_C50F2.4 C50F2.4; 1E456; CE08910; WBGene00016838; WP:CE08910 C50F2.7 Aff_C50F2.7 C50F2.7; 1E468; CE08913; WBGene00016840; WP:CE08913 ViswanathanM et al 2005 S2 sir-2.1 regulated C50F4.4 Aff_C50F4.4 C50F4.4; 5K15b; CE33985; WBGene00008232; WP:CE33985 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C51E3.2 Aff_C51E3.2 srsx-27; C51E3.2; 5K627; CE33986; NM_073208; WBGene00008248; WP:CE33986 opoid receptor C52A10.3 Aff_C52A10.3 C52A10.3; 5F716; CE17584; WBGene00016864; WP:CE17584 ViswanathanM et al 2005 S2 sir-2.1 regulated C52B11.2 Aff_C52B11.2 tag-303; C52B11.2; CE04258; WBGene00016871; WP:CE04258; XB927 potassium channel protein Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit C52D10.6 Aff_C52D10.6 skr-12; C52D10.6; 4S111; CE17590; NM_070644; WBGene00004818; WP:CE17590 skr-12 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-12 has no known function in vivo, since skr-12(RNAi) animals are at least superficially normal. cyclin A-associated protein Lund et al 2002 Fig3D Oocyte-en, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C52D10.7 Aff_C52D10.7 skr-9; C52D10.7; 4S107; CE17591; NM_070642; WBGene00004815; WP:CE17591 skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation. cyclin A-associated protein Jones et al 2001 Non dauer genes P<0.05, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated C52D10.8 Aff_C52D10.8 skr-13; C52D10.8; 4S106; CE17592; NM_070641; WBGene00004819; WP:CE17592 The skr-13 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-13(RNAi) animals are at least superficially normal. cyclin A-associated protein Kwon et al 2004 T1 late-repression Ethanol-respon, Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, Romagnolo et al 2002 Fig3b Proteases, ViswanathanM et al 2005 S2 sir-2.1 regulated C52E2.1 Aff_C52E2.I fbxb-95; C52E2.1; C52E2.I; 2C127; CE25826; WBGene00016880; WP:CE25826 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma C52E2.2 Aff_C52E2.H C52E2.2; C52E2.H; 2C125b; CE20597; WBGene00016881; WP:CE20597 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 C53C11.4 Aff_C53C11.4 C53C11.4; CE04267; WBGene00016901; WP:CE04267; XR923 S. muris microneme antigen C53H9.2 Aff_C53H9.2 C53H9.2; C53H9.2b.1; C53H9.2b.2; C53H9.2b.3; C53H9.2b.4; C53H9.2c.1; C53H9.2c.2; C53H9.2c.3; C53H9.2c.4; 1C307; CE08963; CE33575; CE39907; WBGene00016907; WP:CE08963; WP:CE33575; WP:CE39907 C53H9.2 encodes at least three protein isoforms orthologous to the GTP-binding proteins human GNL1 (HSR1; OMIM:143024) and murine MMR1, as well as LSG1 in S. cerevisiae and many other eukaryotic and bacterial proteins; one alternative transcription unit of the C53H9.2 locus, C53H9.2a, has a natural nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that C53H9.2 is a natural substrate for SMG-mediated nonsense suppresssion; C53H9.2 is required in mass RNAi assays for embryonic viability, normally rapid growth, and early embryonic nuclear positioning; since several other natural mRNA substrates of SMG suppression (e.g., rpl-3, rpl-8, rpl-10a, rpl-12) have protein products that are involved in translation, C53H9.2's protein products may function in translation as well, an inference supported by the observed role of LSG1 in cytoplasmic 60S ribosomal subunit biogenesis. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated C54D1.4 Aff_C54D1.4 alh-10; C54D1.4; C54D1.4.1; C54D1.4.2; CE06980; NM_076802; WBGene00000116; WP:CE06980; XH760 aldehyde dehydrogenase ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 C54D1.5 Aff_C54D1.5 C54D1.5; CE30916; WBGene00016913; WP:CE30916; XH764 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol C54F6.8 Aff_C54F6.8 nhr-171; C54F6.8; 5H991; CE17603; WBGene00016926; WP:CE17603 nuclear hormone receptor Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, ViswanathanM et al 2005 S2 sir-2.1 regulated C55B6.2 Aff_C55B6.2 dnj-7; C55B6.2; CE09008; NM_076808; WBGene00001025; WP:CE09008; XH815 This gene encodes a protein containing a DnaJ ('J') domain that is predicted to be mitochondrial. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 C55B7.3 Aff_C55B7.3 C55B7.3; 1H77; CE09014; WBGene00016942; WP:CE09014 protein-tyrosine phosphatase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm C55B7.4 Aff_C55B7.4 acdh-1; dod-12; C55B7.4; C55B7.4b.1; C55B7.4b.2; C55B7.4b.3; C55B7.4b.4; 1H75; CE09015; CE32840; NM_059470; NM_181994; WBGene00016943; WP:CE09015; WP:CE32840 acyl-CoA dehydrogenase Bishop et al 2004 T1 Upregulated in vhl-1 vs WT, Golden et al 2004, N2 differentially expressed gen, Golden et al 2004, N2 vs daf-2 different genes at , McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated D1005.2 Aff_D1005.2 D1005.2; CE29741; WBGene00016996; WP:CE29741; XC81 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 D1025.2 Aff_D1025.2 D1025.2; CE17610; WBGene00008354; WP:CE17610; XP132 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 D1044.6 Aff_D1044.6 D1044.6; 3G626; CE32173; WBGene00017031; WP:CE32173 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen D1053.1 Aff_D1053.1 gst-42; D1053.1; CE03099; NM_077561; WBGene00001790; WP:CE03099; XM346 gst-42 is orthologous to the human gene GLUTATHIONE TRANSFERASE ZETA-1 (also known as MALEYLACETOACETATE ISOMERASE; GSTZ1; OMIM:603758), which when mutated is thought to lead to a variety of type I tyrosinemia. glutathione S-transferase Kwon et al 2004 T1 late-repression Ethanol-respon, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Romagnolo et al 2002 Fig3b Oxidation, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 D1081.2 Aff_D1081.2 unc-120; D1081.2; 1J37; CE05534; NM_059895; WBGene00006844; WP:CE05534 unc-120 encodes a member of the MADS-box family of transcription factors that contains human and Drosophila serum response factor (SRF) and Saccharomyces cerevisiae MCM1 and ARG80; UNC-120 is required for locomotion and muscle development and for formation of the normal number of muscle A and I bands; UNC-120 is also required for maintaining wild-type expression levels of the muscle components actin and myosin; UNC-120 is first expressed in the early embryo in body wall muscle precursors and later is expressed in both body wall and vulval muscles. MADS domain Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order D2045.7 Aff_D2045.7 D2045.7; 3L565; CE37761; WBGene00008424; WP:CE37761 serine/threonine kinase Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, fem3 enriched genes, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit D2045.9 Aff_D2045.9 D2045.9; CE33988; WBGene00008426; WP:CE33988 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 D2096.1 Aff_D2096.1 D2096.1; 4J163; CE04299; WBGene00017069; WP:CE04299 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA DY3.3 Aff_DY3.3 hlh-16; DY3.3; 1J342; CE15747; NM_059971; WBGene00001960; WP:CE15747 Helix-loop-helix DNA-binding domain E03E2.1 Aff_E03E2.1 cyp-43A1; E03E2.1; E03E2.1.1; E03E2.1.2; CE29747; NM_076560; WBGene00017108; WP:CE29747; XG335 cytochrome P450 ViswanathanM et al 2005 S2 sir-2.1 regulated E04A4.1 Aff_E04A4.1 fbxb-78; E04A4.1; 4F501; CE32346; WBGene00017116; WP:CE32346 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated E04F6.2 Aff_E04F6.2 E04F6.2; 2H491; CE01214; WBGene00017122; WP:CE01214 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated E04F6.3 Aff_E04F6.3 maoc-1; E04F6.3; 2H487; CE01215; WBGene00017123; WP:CE01215 E04F6.3 encodes a protein that is orthologous (with 52% identity over 93% of its length) to residues 334-609 of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE IV (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), a protein of 736 residues whose N- and C-terminal domains are orthologous to DHS-28; E04F6.3 contains a MaoC-like domain, found in diverse enzymes (HSD17B4, peroxisomal hydratase-dehydrogenase-epimerase, and the fatty acid synthase beta subunit); E04F6.3 has no obvious function in mass RNAi assays. Hydratase-dehydrogenase-epimerase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination EEED8.12 Aff_EEED8.12 EEED8.12; 2F700; CE01885; WBGene00017140; WP:CE01885 Probable RNA binding protein Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F01G10.2 Aff_F01G10.2 ech-8; F01G10.2; 4L2; CE35450; NM_069475; WBGene00001157; WP:CE35450 enoyl-CoA hydratase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F01G10.7 Aff_F01G10.7 F01G10.7; 4L4; CE09169; WBGene00008510; WP:CE09169 triacylglycerol lipase Jones et al 2001 Non dauer genes P<0.05 F07A5.7 Aff_F07A5.7 unc-15; F07A5.7; F07A5.7.1; F07A5.7.2; F07A5.7.3; F07A5.7.4; 1H954; CE09197; NM_059684; WBGene00006754; WP:CE09197 The unc-15 gene encodes a paramyosin ortholog; UNC-15 protein physically interacts with MHC A, one isoform of myosin heavy chain (MHC) in striated muscle; UNC-15 accumulation is decreased in the absence of UNC-54 (myosin B), implying that degradation of UNC-15 is inhibited by its binding myosin B; conversely, myosin B (but not MYO-3/myosin A) fails to accumulate in unc-15 mutants. paramyosin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, IVb male soma enriched genes, Roy et al 2002 S2 positivecontrol L1 muscle, ViswanathanM et al 2005 S2 sir-2.1 regulated F07E5.2 Aff_F07E5.2 fbxb-35; F07E5.2; 2C343; CE09215; WBGene00017208; WP:CE09215 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated F07E5.6 Aff_F07E5.6 fbxb-36; F07E5.6; 2C348; CE09218; WBGene00017211; WP:CE09218 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes F08A8.1 Aff_F08A8.1 F08A8.1; F08A8.1a.1; F08A8.1a.2; F08A8.1b.1; F08A8.1b.2; F08A8.1b.3; F08A8.1b.4; F08A8.1c.1; F08A8.1c.2; 1N533; CE17633; CE36125; CE39570; WBGene00008564; WP:CE17633; WP:CE36125; WP:CE39570 F08A8.1 is orthologous to the human gene ACYL-CoA OXIDASE 1, PALMITOYL (ACOX1; OMIM:264470), which when mutated leads to pseudoneonatal adrenoleukodystrophy. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F08B12.2 Aff_F08B12.2 prx-12; F08B12.2; CE03163; NM_077507; WBGene00004197; WP:CE03163; XM13 Zinc finger, C3HC4 type (RING finger) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F08D12.10 Aff_F08D12.10 fbxb-110; sdz-9; F08D12.10; 2D62; CE09243; WBGene00017253; WP:CE09243 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E F08D12.11 Aff_F08D12.11 fbxb-111; F08D12.11; 2D64; CE09244; WBGene00017254; WP:CE09244 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F08D12.8 Aff_F08D12.8 fbxb-105; F08D12.8; 2D58; CE09241; WBGene00017251; WP:CE09241 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08D12.9 Aff_F08D12.9 fbxb-109; sdz-10; F08D12.9; 2D60; CE09242; WBGene00017252; WP:CE09242 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol F08G12.1 Aff_F08G12.1 F08G12.1; CE03166; WBGene00008585; WP:CE03166; XL922 ras-related like protein F08G2.7 Aff_F08G2.7 F08G2.7; 2O128; CE19779; WBGene00008578; WP:CE19779 F08H9.3 Aff_F08H9.3 F08H9.3; 5O942; CE09267; WBGene00008591; WP:CE09267 F08H9.3 encodes a heat shock protein (HSP) of the HSP16 class; unlike most HSP16s in C. elegans, it is specifically expressed in a particular tissue (the larval pharynx and the anterior adult pharynx), and its expression is not strongly induced by heat shock; however, F08H9.3 expression is increased by heat shock (with adult expression in the full pharynx) and probably aids heat shock resistance, since F08H9.3(RNAi) animals have sensitivity to heat shock that is sporadically higher than normal; in general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP. heat shock protein Kwon et al 2004 T1 Class1 rapid-induction Ethanol, Lund et al 2002 Aging time course Fig2C heatshock, Lund et al 2002 Fig4 Mount 15, Romagnolo et al 2002 Fig2a heat shock F09C3.4 Aff_F09C3.4 fbxa-103; F09C3.4; 1O876; CE09279; WBGene00008612; WP:CE09279 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F09C3.5 Aff_F09C3.3 fbxb-69; F09C3.5; 1O872; CE24886; WBGene00008613; WP:CE24886 F09E5.10 Aff_F09E5.10 F09E5.10; 2F638; CE02605; WBGene00017288; WP:CE02605 ViswanathanM et al 2005 S2 sir-2.1 regulated F10C1.5 Aff_F10C1.5 dmd-5; F10C1.5; 2G62; CE29753; WBGene00017326; WP:CE29753 D. melanogaster doublesex protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F10D2.10 Aff_F10D2.10 F10D2.10; 5H634; CE32860; WBGene00017335; WP:CE32860 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, fem3 enriched genes, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F10D2.12 Aff_F10D2.8 F10D2.12; 5H628; CE30746; WBGene00017337; WP:CE30746 F10D2.6 Aff_F10D2.6 ugt-37; F10D2.6; 5H616; CE30747; WBGene00017332; WP:CE30747 7TM chemoreceptor, ugt family Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F10D7.3 Aff_F10D7.3 F10D7.3; CE29754; WBGene00017340; WP:CE29754; XR988 This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. glutaredoxin McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F10E7.1 Aff_F10E7.1 F10E7.1; 2H419; CE39350; WBGene00017343; WP:CE39350 ViswanathanM et al 2005 S2 daf-16 Resveratrol F10E9.6 Aff_F10E9.6 mig-10; F10E9.6; F10E9.6a.1; F10E9.6a.2; 3J395; CE00150; CE29261; CE36129; NM_066420; NM_066421; WBGene00003243; WP:CE00150; WP:CE29261; WP:CE36129 mig-10 encodes a protein containing a pleckstrin homology domain and a proline-rich region, and is similar to the SH2-domain containing adapter proteins Grb7 and Grb10 which are involved in receptor tyrosine kinase-mediated signal transduction; MIG-10 is likely required for signal transduction during cell migration, as it is required non-cell autonomously for excretory canal development and anterior-posterior migrations of the embryonic neurons ALM, CAN, and HSN; mig-10 mutations appear to interact genetically with mutations in all three C. elegans rac genes, ced-10, mig-2, and rac-2, suggesting partial redundancy during neuronal migration and excretory canal outgrowth; MIG-10 is expressed in many embryonic cells and in four cells in the adult head. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F11A3.1 Aff_F11A3.1 F11A3.1; F11A3.1.1; F11A3.1.2; 5J989; CE05585; WBGene00008669; WP:CE05585 4-coumarate-CoA ligase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F11C1.6 Aff_F11C1.6 nhr-25; F11C1.6; F11C1.6a.1; F11C1.6a.2; F11C1.6b.1; F11C1.6b.2; F11C1.6b.3; CE03191; CE35856; NM_077761; WBGene00003623; WP:CE03191; WP:CE35856; XN631 nhr-25 encodes a nuclear hormone receptor orthologous to Drosophila Ftz-F1; NHR-25 is required for embryogenesis, molting, vulval and gonadal development, and hypodermal expression of acn-1; nhr-25 is expressed in gonads and loaded into embryos as a maternal transcript; nhr-25 is zygotically expressed in progeny of the E cell, and then in hypodermis and gut; the role of NHR-25 in molting may be evolutionarily conserved between nematodes and arthopods. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F11C3.2 Aff_F11C3.2 cof-1; ofm-1; unc-122; F11C3.2; 1P467; CE20668; NM_061197; WBGene00006845; WP:CE20668 unc-122 encodes a predicted type II transmembrane protein with extracellular collagen-like domains and a highly conserved olfactomedin (OLF) domain that is found in a family of secreted proteins involved in formation and function of nervous systems; UNC-122 is required for proper locomotion and for normal morphology of the DVB motorneuron, and may regulate neuromuscular function by acting in an aminergic/peptidergic pathway parallel to cholinergic neurotransmission; although mosaic analysis indicates that UNC-122 activity is required in muscle cells, the precise expression and localization patterns of UNC-122 are not yet known. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F11E6.1 Aff_4R79.3, Aff_F11E6.1 F11E6.1; 4S421; CE20669; CE26698; CE31166; WBGene00008706; WP:CE20669; WP:CE26698; WP:CE31166 F11E6.1 is homologous to to the human gene GLUCOCEREBROSIDASE (GBA; OMIM:606463), which when mutated leads to Gaucher disease. Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, IVb male soma enriched genes, Reinke et al 2004, mixed sperm soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 genes pass two-wayANOVA P0 F11F1.7 Aff_F11F1.7 F11F1.7; 3O495; CE15807; WBGene00008719; WP:CE15807 Transthyretin-like family F13C5.2 Aff_F13C5.2 F13C5.2; CE19384; WBGene00017423; WP:CE19384; XB213 bromodomain-containing protein McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol F13E9.13 Aff_F13E9.3 F13E9.6 Aff_F13E9.6 sdz-13; F13E9.6; 4L642; CE05608; WBGene00008755; WP:CE05608 F14B4.1 Aff_F14B4.1 F14B4.1; 1J842; CE38950; WBGene00008779; WP:CE38950 LDL receptor-related protein Reinke et al 2004, list of genes in cluster order F14B6.1 Aff_F14B6.1 sdz-14; F14B6.1; 1M808; CE17663; WBGene00008782; WP:CE17663 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F14B6.3 Aff_F14B6.3 F14B6.3; 1M823; CE17665; WBGene00008784; WP:CE17665 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol F14B6.6 Aff_F14B6.6 F14B6.6; 1M825; CE25856; WBGene00008787; WP:CE25856 Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F14E5.4 Aff_F14E5.4 F14E5.4; 2I720; CE03207; WBGene00008802; WP:CE03207 acid phosphatase Reinke et al 2004, male sperm, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, mixed sperm soma, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, GO categories F15A4.2 Aff_F15A4.2 F15A4.2; 2M755; CE15839; WBGene00008838; WP:CE15839 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F16H11.2 Aff_F16H11.2 F16H11.2; CE04397; WBGene00017531; WP:CE04397; XF281 ViswanathanM et al 2005 S2 sir-2.1 regulated F17A9.5 Aff_F17A9.5 F17A9.5; 5G592; CE09449; WBGene00017537; WP:CE09449 Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination F17C11.2 Aff_F17C11.2 F17C11.2; F17C11.2.1; F17C11.2.2; 5L427; CE05649; WBGene00008914; WP:CE05649 Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F17C8.4 Aff_F17C8.4 ras-2; F17C8.4; F17C8.4.1; F17C8.4.2; F17C8.4.3; 3F828; CE00958; NM_065571; Ras2; WBGene00004311; WP:CE00958 ras-2 encodes member of the Ras subfamily of RAS small GTPases with highest similarity to human M-Ras Ras-like protein Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order F17E9.13 Aff_F35H10.1 his-33; F17E9.13; 4J100; NM_069007; WBGene00001907 his-33 encodes an H2A histone; by homology, HIS-33 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-33 is a replication-dependent histone locus that resides in the HIS5 cluster on chromosome IV. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated F18A11.4 Aff_Y38F1A.M F18A11.4; Y38F1A.M; 2N306; CE20689; WBGene00008931; WP:CE20689 F18C5.10 Aff_F18C5.4 F18C5.10; F18C5.10.1; F18C5.10.2; 2G850; CE31790; WBGene00017563; WP:CE31790 F18E9.5 Aff_F18E9.5 tag-279; F18E9.5; CE30957; CE30958; WBGene00017571; WP:CE30957; WP:CE30958; XJ193 Murphy et al 2003 Fig2 Class2 shorten lifespan F18F11.1 Aff_F18F11.1 F18F11.1; 4B88; CE17684; WBGene00017574; WP:CE17684 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F19C6.5 Aff_F19C6.5 F19C6.5; CE01558; WBGene00008954; WP:CE01558; XK598 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C F19C7.3 Aff_F19C7.3 F19C7.3; 4F361; CE04417; WBGene00017593; WP:CE04417 F19F10.1 Aff_F19F10.1 F19F10.1; 5I41; CE09481; WBGene00017598; WP:CE09481 DNA-binding protein Jiang et al 2001 Fig1 male-enriched TF, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F19F10.5 Aff_F19F10.5 F19F10.5; 5I36; CE09485; WBGene00017601; WP:CE09485 DNA-binding protein ViswanathanM et al 2005 S2 sir-2.1 regulated F19H8.1 Aff_F19H8.1 tps-2; F19H8.1; CE37507; NM_064634; WBGene00006603; WP:CE37507 tps-2 encodes one of two trehalose-6-phosphate synthase proteins in C. elegans, and RNAi of both enzymes leads to a more than 90% reduction decrease in trehalose levels, but does not appear to affect viability or development; the tps-2 mRNA is expressed throughout development. trehalose phosphate synthase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan F20C5.2 Aff_F20C5.2 klp-11; F20C5.2; 4J520; CE03239; CE27986; NM_171407; WBGene00002222; WP:CE03239; WP:CE27986; krp95 klp-11 encodes a predicted kinesin protein with high similarity to OSM-3 in the motor domain and encodes one of the motor subunits of heterotrimeric CeKinesin-II; expressed throughout the nervous system. kinesin ViswanathanM et al 2005 S2 daf-16 Resveratrol F21A3.2 Aff_F21A3.2 F21A3.2; 5Q12; CE31909; WBGene00008992; WP:CE31909 acid phosphatase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F21A9.2 Aff_F21A9.2 F21A9.2; 1E272; CE09522; WBGene00017651; WP:CE09522 zinc finger protein Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, fem3 enriched genes F21D5.9 Aff_F21D5.9 F21D5.9; 4J485; CE03251; WBGene00009014; WP:CE03251 Zinc finger, C2H2 type ViswanathanM et al 2005 S2 sir-2.1 regulated F21D9.1 Aff_F21D9.1 F21D9.1; 5T745; CE18627; WBGene00009015; WP:CE18627 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F21D9.3 Aff_F21D9.3 F21D9.3; 5T724; CE18629; WBGene00009017; WP:CE18629 Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, shared sperm F21D9.5 Aff_F21D9.5 F21D9.5; 5T721; CE18631; WBGene00009019; WP:CE18631 F22B7.9 Aff_F22B7.9 F22B7.9; 3J742; CE29771; WBGene00017698; WP:CE29771 Jones et al 2001 Dauer specific genes P<0.05, Kwon et al 2004 T1 late-repression Ethanol-respon, Lund et al 2002 Fig4 Mount 15, Romagnolo et al 2002 Fig3b Unkown, Romagnolo et al 2002 Fig5 genes in let-60 timecour, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S8 SAGE genes in the dauer exit, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F22B8.6 Aff_F22B8.6 F22B8.6; F22B8.6.1; F22B8.6.2; 5Q581; CE15884; WBGene00009048; WP:CE15884 cystathione gamma-lyase like Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F22E5.1 Aff_F22E5.1 F22E5.1; 2C965; CE09553; WBGene00017703; WP:CE09553 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F22E5.17 Aff_F34D6.1 F22E5.17; 2C969; CE27992; WBGene00017712; WP:CE27992 F22G12.3 Aff_F22G12.3 F22G12.3; 1N737; CE15890; WBGene00009063; WP:CE15890 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F22G12.5 Aff_F22G12.5 F22G12.5; 1N773; CE15892; WBGene00009065; WP:CE15892 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F22H10.4 Aff_F22H10.4 F22H10.4; CE09573; WBGene00017728; WP:CE09573; XR296 F23A7.1 Aff_F23A7.1 F23A7.1; CE09576; WBGene00009067; WP:CE09576; XQ831 F23D12.5 Aff_F23D12.5 F23D12.5; CE15893; WBGene00009089; WP:CE15893; XP71 F23F12.4 Aff_F23F12.4 sdz-15; F23F12.4; 3H587; CE01251; WBGene00017752; WP:CE01251 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated F23F12.9 Aff_F23F12.9 F23F12.9; 3H569; CE01256; CE32389; WBGene00017755; WP:CE01256; WP:CE32389 Portman et al 2004 T1 25 candidate ray genes, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order F25B4.6 Aff_F25B4.6 phi-50; F25B4.6; 5G164; CE09624; WBGene00017769; WP:CE09624 F25B4.6 is orthologous to the human gene 3-HYDROXY-3-METHYLGLUTARYL COA SYNTHASE (HMGCS2; OMIM:600234), which when mutated leads to disease. hydroxymethlglutaryl-CoA synthase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F25B4.8 Aff_F25B4.8 F25B4.8; 5G170; CE30761; CE30762; WBGene00017771; WP:CE30761; WP:CE30762 ViswanathanM et al 2005 S2 sir-2.1 regulated F25C8.2 Aff_F25C8.2 amx-3; F25C8.2; 5V368; CE39726; NM_075633; WBGene00000139; WP:CE39726 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F25C8.4 Aff_F25C8.4 F25C8.4; 5V375; CE18637; WBGene00009106; WP:CE18637 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. AMP-binding enzymes ViswanathanM et al 2005 S2 sir-2.1 regulated F25G6.3 Aff_F25G6.3 acr-16; F25G6.3; 5J43; CE09639; CE32878; Ce21; NM_072806; WBGene00000055; WP:CE09639; WP:CE32878 acr-16 encodes an alpha-7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily orthologous to human nicotinic cholinergic receptor alpha 7 (CHRNA7; OMIM:118511; possibly associated with schizophrenia and juvenile myoclonic epilepsy); ACR-16 functions as a ligand-gated ion channel that probably regulates fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-16 is active as a homomeric receptor and responds robustly to acetylcholine when expressed in Xenopus oocytes. Lund et al 2002 Fig3B neuro-specific genes, Romagnolo et al 2002 Fig3b signaling, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F26A1.2 Aff_F26A1.2 fkh-5; F26A1.2; 3F935; CE02683; NM_065602; WBGene00001437; WP:CE02683 fkh-5 encodes a member of the forkhead domain transcription factor family. F26D10.11 Aff_F26D10.11 F26D10.11; 4S219; CE19811; WBGene00009155; WP:CE19811 F26D10.11 encodes an ortholog of murine TMHS (mutated in hurry-scurry/hscy mice), a predicted tetraspan membrane protein required for stereociliary function and a possible ortholog of human DFNB53; the cysteine mutated in hscy mice is conserved in F26D10.11. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F27D9.6 Aff_F27D9.6 dhs-29; F27D9.6; CE28011; NM_076893; WBGene00000992; WP:CE28011; XI282 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 F27E11.3 Aff_F27E11.3 cfz-2; F27E11.3; 5D920; CE39149; CE39150; CFZ2; NM_071563; NM_071564; WBGene00000478; WP:CE39149; WP:CE39150 cfz-2 encodes a member of the Frizzled family of membrane receptors. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol F28H1.1 Aff_F28H1.1 F28H1.1; 1E565; CE09766; WBGene00017908; WP:CE09766 ViswanathanM et al 2005 S2 sir-2.1 regulated F29A7.1 Aff_F29A7.1 fbxb-106; F29A7.1; 2D53; CE09772; WBGene00017911; WP:CE09772 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes F29A7.2 Aff_F29A7.2 fbxb-107; F29A7.2; 2D51; CE36834; WBGene00017912; WP:CE36834 F29F11.6 Aff_F29F11.6 CEGLC-7A; Ce-glc-7alpha; glc-7; gsp-1; F29F11.6; F29F11.6.1; F29F11.6.2; F29F11.6.3; F29F11.6.4; 5L165; CE20735; NM_073332; WBGene00001747; WP:CE20735 serine/threonine protein phosphatase ViswanathanM et al 2005 S2 sir-2.1 regulated F29G9.1 Aff_F29G9.1 F29G9.1; 5G519; CE35297; WBGene00017930; WP:CE35297 Jones et al 2001 Non dauer genes P<0.05, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen F30A10.10 Aff_F30A10.10 F30A10.10; 1K87; CE32639; WBGene00009267; WP:CE32639 ubiquitin carboxyl-termianl hydrolase Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated F30F8.5 Aff_F30F8.5 F30F8.5; 1I424; CE37511; WBGene00009274; WP:CE37511 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol F31D5.6 Aff_F31D5.6 F31D5.6; 2E501; CE19829; WBGene00017949; WP:CE19829 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated F31E9.4 Aff_F31E9.4 sdz-16; F31E9.4; 5R806; CE15938; WBGene00009297; WP:CE15938 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated F32A11.6 Aff_F32A11.6 moe-3; F32A11.6; 2N452; CE18657; NM_064394; WBGene00003388; WP:CE18657 Zinc finger C-x8-C-x5-C-x3-H type (and similar). ViswanathanM et al 2005 S2 sir-2.1 regulated F32A5.6 Aff_F32A5.6 prx-13; F32A5.6; 2H540; CE28290; NM_063112; WBGene00004198; WP:CE28290 prx-13 is orthologous to the human gene PEX13 (OMIM:601789), which when mutated leads to Zellweger syndrome or neonatal adrenoleukodystrophy. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F32B6.6 Aff_F32B6.6 msp-77; F32B6.6; 4K659; CE09861; NM_069380; WBGene00003464; WP:CE09861 msp-77 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm F32H2.6 Aff_F32H2.6 phi-46; F32H2.6; 1J574; CE09881; WBGene00009343; WP:CE09881 fatty acid synthase (N-terminus) Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F33E11.1 Aff_F33E11.1 nhr-15; F33E11.1; 5A799; CE17759; NM_070773; WBGene00003614; WP:CE17759 nhr-15 is predicted to encode a member of the nuclear hormone receptor family. nuclear hormone receptor Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F34D10.3 Aff_F34D10.3 F34D10.3; 3E825; CE00963; WBGene00009373; WP:CE00963 F35C11.6 Aff_F35C11.6 F35C11.6; 2I548; CE02212; WBGene00009405; WP:CE02212 F35E2.2 Aff_F35E2.2 F35E2.2; 1M326; CE17772; WBGene00009410; WP:CE17772 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated F35E2.8 Aff_F35E2.8 F35E2.8; 1M309; CE17777; WBGene00009415; WP:CE17777 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated F35G2.4 Aff_F35G2.4 phy-2; F35G2.4; F35G2.4.1; F35G2.4.2; 4M976; CE05811; NM_069916; WBGene00004025; WP:CE05811 prolyl 4-hydroxylase alpha subunit McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Romagnolo et al 2002 Fig3b others F35H8.7 Aff_F35H8.7 wee-1.1; F35H8.7; 2J872; CE09940; NM_063657; WBGene00006938; WP:CE09940 serine/threonine kinase ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F36A2.3 Aff_F36A2.3 F36A2.3; 1J377; CE15964; WBGene00009453; WP:CE15964 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F36A4.8 Aff_F36A4.8 F36A4.8; F36A4.8.1; F36A4.8.2; 4F11; CE07184; WBGene00018085; WP:CE07184 F36H1.6 Aff_F36H1.6 alh-3; F36H1.6; 4L789; CE05817; NM_069653; WBGene00000109; WP:CE05817 alh-3 encodes an aldehyde dehydrogenase predicted to be mitochondrial. formyltetrahydrofolate dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination F36H5.4 Aff_F36H5.4 F36H5.4; 2C53; CE09961; WBGene00018103; WP:CE09961 F36H5.8 Aff_F36H5.8 F36H5.8; 2C38; CE09965; WBGene00018106; WP:CE09965 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Murphy et al 2003 Fig2 Class2 shorten lifespan F37C4.4 Aff_F37C4.4 F37C4.4; F37C4.4b.1; F37C4.4b.2; 4E635; CE17047; CE31505; WBGene00018144; WP:CE17047; WP:CE31505 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 F37D6.4 Aff_F37D6.4 F37D6.4; 1L65; CE05821; WBGene00009510; WP:CE05821 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma F37H8.5 Aff_F37H8.5 F37H8.5; CE15997; WBGene00009514; WP:CE15997 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F38A6.1 Aff_F38A6.1 Ce-fkh-1; fkh-1; pha-4; F38A6.1; 5V229; CE15998; NM_075605; WBGene00004013; WP:CE15998 Fork head domain, eukaryotic transcription factors Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit F38B6.6 Aff_F38B6.6 F38B6.6; CE30976; WBGene00018175; WP:CE30976; XH300 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol F38C2.5 Aff_F38C2.5 F38C2.5; 4R43; CE16004; WBGene00009537; WP:CE16004 Zinc finger C-x8-C-x5-C-x3-H type (and similar). (2 domains) Lund et al 2002 Fig3D Oocyte-en, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F38C2.7 Aff_F38C2.7 F38C2.7; 4R32; CE16006; WBGene00009539; WP:CE16006 Zinc finger C-x8-C-x5-C-x3-H type (and similar). (2 domains) ViswanathanM et al 2005 S2 sir-2.1 regulated F38E9.5 Aff_F38E9.5 F38E9.5; F38E9.5.1; F38E9.5.2; CE28307; WBGene00018187; WP:CE28307; XR65 protein tyrosine kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C F38H4.2 Aff_F38H4.2 fbxb-3; F38H4.2; 4M605; CE10060; WBGene00009546; WP:CE10060 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated F39B2.8 Aff_Y105E8A.VV F39B2.8; CE30529; WBGene00009558; WP:CE30529 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F39F10.4 Aff_F39F10.4 F39F10.4; CE07206; WBGene00018204; WP:CE07206; XR516 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma F39G3.2 Aff_F39G3.2 F39G3.2; 5F217; CE35304; WBGene00018207; WP:CE35304 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F39G3.5 Aff_F39G3.5 F39G3.5; 5F201; CE10120; CE36933; WBGene00018210; WP:CE10120; WP:CE36933 Golden et al 2004, N2 vs daf-2 different genes at , Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order F40E10.1 Aff_F40E10.1 hch-1; nas-34; F40E10.1; CE24964; NM_078039; WBGene00001828; WP:CE24964; XP316 hch-1 encodes a member of the zinc-dependent metalloprotease family that contains an epidermal growth factor-like domain, a CUB domain, and a TSP1 domain and affects hatching and QL neuroblast migration. metalloprotease Golden et al 2004, N2 vs daf-2 different genes at , Golden et al 2004, N2 vs daf-2 age different gene, Jones et al 2001 Non dauer genes P<0.05 F40F11.2 Aff_F40F11.2 F40F11.2; 4M365; CE28557; WBGene00009587; WP:CE28557 ViswanathanM et al 2005 S2 sir-2.1 regulated F40F4.1 Aff_F40F4.1 fbxb-71; F40F4.1; CE04531; WBGene00018236; WP:CE04531; XD883 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Murphy et al 2003 Fig2 Class2 shorten lifespan, Romagnolo et al 2002 Fig3b Unkown, Romagnolo et al 2002 Fig5 genes in let-60 timecour, ViswanathanM et al 2005 S2 sir-2.1 regulated F40F9.5 Aff_F40F9.5 F40F9.5; 5K202; CE37834; WBGene00009582; WP:CE37834 translocase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F40G9.12 Aff_F40G9.12 F40G9.12; 3A789; CE19859; WBGene00018247; WP:CE19859 ViswanathanM et al 2005 S2 sir-2.1 regulated F40G9.5 Aff_F40G9.5 F40G9.5; 3A799; CE19852; WBGene00018241; WP:CE19852 Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F40G9.6 Aff_F40G9.6 F40G9.6; 3A795; CE19853; WBGene00018242; WP:CE19853 Reinke et al 2004, list of genes in cluster order F40G9.9 Aff_F40G9.9 F40G9.9; 3A784; CE32413; WBGene00018245; WP:CE32413 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F40H6.4 Aff_F40H6.4 CE-TBX-11; tbx-11; F40H6.4; 3H134; CE01281; NM_065916; WBGene00006547; WP:CE01281 tbx-11 encodes a T-box transcription factor that is orthologous to members of the Tbx2 subfamily of T-box transcription factors; by homology, TBX-11 is predicted to function in transcriptional regulation during cellular differentiation, potentially as both an activator and a repressor; however, as loss of tbx-11 function via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of tbx-11 in C. elegans development and/or behavior is not yet known. Reinke et al 2004, list of genes in cluster order F41C6.1 Aff_F41C6.1 unc-106; unc-6; F41C6.1; F41C6.1.1; F41C6.1.2; CE04538; NM_076764; WBGene00006746; WP:CE04538; XH515 unc-6 encodes a netrin orthologous to the human and mouse netrin-1 precursor proteins; UNC-6 functions as a guidance molecule that regulates the migrations of pioneer axons and mesodermal cells, such as the gonadal distal tip cell, along the dorsoventral axis; a secreted molecule, UNC-6 is expressed during embryogenesis by epidermoblasts and neurons; UNC-6 is involved in both attractive and repulsive interactions that are mediated by the UNC-40 and UNC-5 netrin receptors, respectively. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F41D9.3 Aff_F41D9.3 wrk-1; F41D9.3; F41D9.3b.1; F41D9.3b.2; CE30985; CE30986; CE30987; CE34015; CE37643; WBGene00006942; WP:CE30985; WP:CE30986; WP:CE30987; WP:CE34015; WP:CE37643; XJ6 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F41E6.5 Aff_F41E6.5 F41E6.5; 5J85; CE31936; WBGene00018286; WP:CE31936 glycolate oxidase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F41E6.6 Aff_F41E6.6 tag-196; F41E6.6; F41E6.6.1; F41E6.6.2; 5J77; CE35305; WBGene00007055; WBGene00018287; WP:CE35305 cysteine protease and a protease inhibitor Kwon et al 2004 T1 late-induction Ethanol-response, Lund et al 2002 Fig1 aging-regulated genes, Lund et al 2002 Fig4 Mount 15, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated F42E11.1 Aff_F42E11.1 pgp-4; F42E11.1; F42E11.1.1; F42E11.1.2; CE03308; NM_077501; WBGene00003998; WP:CE03308; XL981 pgp-4 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-4 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-4 activity via deletion mutations or RNAi results in no obvious defects, the precise role of PGP-4 in C. elegans development and/or behavior is not yet known; pgp-4 promoter-gfp fusion proteins are expressed in the larval excretory cell. p-glycoprotein F42F12.4 Aff_F42F12.4 F42F12.4; F42F12.4.1; F42F12.4.2; CE16031; WBGene00009636; WP:CE16031; XM970 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F42G2.6 Aff_F42G2.6 F42G2.6; 2C718; CE32659; WBGene00018355; WP:CE32659 Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol F42G9.4 Aff_F42G9.4 F42G9.4; 3B379; CE30789; WBGene00018363; WP:CE30789 Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F43C11.6 Aff_F43C11_37.D F43C11.6; 2C633; CE20780; WBGene00018383; WP:CE20780 ViswanathanM et al 2005 S2 sir-2.1 regulated F43C9.4 Aff_F43C9.4 mig-13; F43C9.4; CE28324; CE34562; NM_076419; WBGene00003245; WP:CE28324; WP:CE34562; XF416 mig-13 encodes a novel single-pass transmembrane protein with a N-terminal signal sequence and two motifs that have been implicated in protein-protein interactions: a CUB domain and a LDL receptor repeat; mig-13 affects the migration and thus the positioning of the Q neuroblasts and their descendants and also the anterior migration of the BDU neuron and may be a component of a global anterior/posterior migration system; a mig-13-gfp translational fusion protein is expressed in embryonic pharyngeal, hypodermal and anterior body neuronal precursors as well as in the cell bodies and axons of a number of neurons in the retrovascular ganglion and the ventral cord; mig-13 localizes to the plasma membrane; mig-13 expression along the A/P axis is restricted by hox gene activity. F43G6.11 Aff_F43G6.4 F43G6.11; 2M91; CE31698; CE31699; NM_171044; NM_171045; WBGene00009663; WP:CE31698; WP:CE31699 Wang et al 2003 S6 removed genes of contamination F43G6.5 Aff_F43G6.5 F43G6.5; 2M106; CE23726; WBGene00009658; WP:CE23726 poly (A) polymerase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F44A2.7 Aff_F44A2.7 F44A2.7; 5J799; CE35308; WBGene00018406; WP:CE35308 F44B9.3 Aff_F44B9.3 cit-1.2; F44B9.3; 3J103; CE29042; CE32417; NM_066344; NM_181926; WBGene00000508; WP:CE29042; WP:CE32417 cit-1.2 encodes one of two C. elegans cyclin T orthologs; RNAi experiments indicate that CIT-1.2 functions redundantly with CIT-1.1 to broadly regulate embryonic transcription; by homology, CIT-1.1 and CIT-1.2 are predicted to interact with the CDK-9 kinase to form the P-TEFb transcription elongation factor that in C. elegans is required for Ser2, but not Ser5, phosphorylation in the C-terminal domain (CTD) repeat of AMA-1/PolII. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F44C4.5 Aff_F44C4.5 ppt-1; F44C4.5; 5H104; CE07253; NM_072283; WBGene00004092; WP:CE07253 ppt-1 is orthologous to the human gene PALMITOYL-PROTEIN THIOESTERASE 1 (PPT1; OMIM:600722), which when mutated leads to infantile neuronal ceroid lipofuscinosis 1 (OMIM:256730) and juvenile neuronal ceroid lipofuscinosis with granular osmiophilic deposits (OMIM:600680). palmitoyl-protein thioesterase precursor Lund et al 2002 Fig1 aging-regulated genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, IVb male soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F44E5.2 Aff_F44E5.2 F44E5.2; 2M63; CE18677; WBGene00009689; WP:CE18677 Leucine Rich Repeat (2 copies) F44E5.3 Aff_F44E5.3 F44E5.3; 2M52; CE18678; WBGene00009690; WP:CE18678 F44E5.4 Aff_F44E5.4 F44E5.4; F44E5.4.1; F44E5.4.2; 2M48; CE18679; WBGene00009691; WP:CE18679 Heat shock hsp70 proteins Custodia et al 2001 T2 heat shock, GuhaThakurta et al 2002 T1 upregu on heat stress, Lund et al 2002 Aging time course Fig2C heatshock, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig2a heat shock, Shen et al 2005 T1 hif-1indepen hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated F44F1.4 Aff_F44F1.4 F44F1.4; 1N856; CE10418; WBGene00009696; WP:CE10418 ViswanathanM et al 2005 S2 sir-2.1 regulated F44F1.5 Aff_F44F1.5 F44F1.5; 1N848; CE10420; WBGene00009697; WP:CE10420 F44F1.6 Aff_F44F1.6 F44F1.6; 1N854; CE23728; CE23729; WBGene00009698; WP:CE23728; WP:CE23729 ViswanathanM et al 2005 S2 daf-16 Resveratrol F44F1.7 Aff_F44F1.7 vet-6; F44F1.7; 1N863; CE10424; NM_060931; WBGene00006902; WBGene00009699; WP:CE10424 vet-6 encodes a protein that contains a spectrin repeat; vet-6 is preferentially transcribed in embryos prior to gastrulation. ViswanathanM et al 2005 S2 sir-2.1 regulated F45C12.11 Aff_F45C12.11 bath-32; sdz-18; F45C12.11; 2B994; CE10456; WBGene00018442; WP:CE10456 ViswanathanM et al 2005 S2 sir-2.1 regulated F45C12.13 Aff_F45C12.13 fbxb-48; F45C12.13; 2C6; CE10460; WBGene00018444; WP:CE10460 F45C12.14 Aff_F45C12.14 fbxb-5; F45C12.14; 2C8; CE36850; WBGene00018445; WP:CE36850 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. F45C12.6 Aff_F45C12.6 F45C12.6; 2C13; CE10446; WBGene00018437; WP:CE10446 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F45D11.13 Aff_F45D11_40.E fbxb-30; F45D11.13; 2B292; CE35933; WBGene00018458; WP:CE35933 F45D11.5 Aff_F45D11_40.I F45D11.5; F45D11.M; 2B293; CE35934; WBGene00018452; WP:CE35934 F45D11.6 Aff_F45D11_40.H F45D11.6; 2B289; CE35935; WBGene00018453; WP:CE35935 F45D3.1 Aff_F45D3.1 F45D3.1; 5N7; CE10468; WBGene00009721; WP:CE10468 F45H10.4 Aff_F45H10.4 drr-1; F45H10.4; 2N786; CE10548; WBGene00009741; WP:CE10548 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F45H11.1 Aff_F45H11.1 F45H11.1; 1K947; CE16055; CE38353; WBGene00009743; WP:CE16055; WP:CE38353 Zinc finger, C2H2 type F46A9.6 Aff_C17E4.11 mec-8; F46A9.6; F46A9.6.1; F46A9.6.2; F46A9.6.3; 1K18; CE08260; NM_060107; WBGene00003172; WP:CE08260 mecanosensory gene mec-8 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F47A4.2 Aff_F47A4.2 dpy-22; mdt-12; psa-6; sop-1; F47A4.2; CE16058; NM_077244; WBGene00001081; WP:CE16058; XK430 dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation; DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression. Reinke et al 2004, wt herm vs wt male enriched gen F48E3.6 Aff_F48E3.6 F48E3.6; CE02753; WBGene00018606; WP:CE02753; XI120 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E F48E8.1 Aff_F48E8.1 lon-1; F48E8.1; 3G567; CE01953; CE29046; CE30996; NM_065765; NM_065766; NM_171866; WBGene00003055; WP:CE01953; WP:CE29046; WP:CE30996 The lon-1 gene encodes a protein belonging to the PR-protein superfamily that is a target of DBL-1 (TGF-beta) signaling, and that regulates polyploidization and body length. ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F49B2.1 Aff_F49B2.1 fbxb-8; F49B2.1; 1O891; CE28559; WBGene00009861; WP:CE28559 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Lund et al 2002 Fig1 aging-regulated genes F49B2.2 Aff_F49B2.2 fbxb-67; F49B2.2; 1O885; CE16073; WBGene00009862; WP:CE16073 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol F49D11.9 Aff_F49D11.9 tag-296; F49D11.9; 1L520; CE17083; CE33286; WBGene00018632; WP:CE17083; WP:CE33286 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F49E12.6 Aff_F49E12.6 F49E12.6; 2I705; CE37018; WBGene00009899; WP:CE37018 The F49E12.6 gene encodes a protein with two E2F domains that may be involved in apoptosis. RBB3 like protein Jiang et al 2001 Fig3 Rb complex genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol F49H6.5 Aff_F49H6.5 F49H6.5; 5R501; CE18715; WBGene00009908; WP:CE18715 The F49H6.5 gene encodes a homolog of the human gene MOCS1A, which when mutated leads to molybdenum cofactor deficiency (OMIM:252150). F52E4.8 Aff_F32E4.8 F32E4.8; F52E4.8; CE09875; WBGene00018704; WP:CE09875; XD718 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F52G3.1 Aff_F52G3.1 F52G3.1; CE28439; WBGene00018710; WP:CE28439; XR585 ViswanathanM et al 2005 S2 daf-16 Resveratrol F52G3.5 Aff_F52G3.5 F52G3.5; CE35720; WBGene00018713; WP:CE35720; XR588 ViswanathanM et al 2005 S2 sir-2.1 regulated F52H3.1 Aff_F52H3.1 let-268; F52H3.1; F52H3.1.1; F52H3.1.2; F52H3.1.3; 2K324; CE03397; NM_063769; WBGene00002497; WP:CE03397 let-268 encodes a procollagen lysyl hydroxylase that processes type IV collagen, a collagen secreted and incorporated into the basement membrane during embryogenesis (and encoded partly by emb-9); LET-268 activity is essential for type IV collagen processing and secretion and for the stability, but not the formation of, the basement membrane that provides mechanical support to body wall muscle once contraction begins; LET-268 also appears to be required for pharyngeal muscle contraction. procollagen-lysine,2-oxoglutarate 5-dioxygenase precusor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F52H3.5 Aff_F52H3.5 F52H3.5; 2K321; CE03401; WBGene00009947; WP:CE03401 Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F53B2.6 Aff_F53B2.6 ham-1; F53B2.6; 4N309; CE17851; NM_070000; WBGene00001820; WP:CE17851 ham-1 encodes a novel protein with a winged helix DNA-binding motif; ham-1 is required for the asymmetric divisions of several neuroblasts in the developing embryo and may influence their spindle position; ham-1 mutations also exhibit HSN motor neuron migration defects; HAM-1 interacts with itself in a yeast two-hybrid screen and observations suggest that its multimerization is required for its proper localization; HAM-1 is cytoplasmic and is asymmetrically distributed to the posterior of the HSNPHB neuroblast. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F53C3.11 Aff_F53C3.11 F53C3.11; 2E196; CE19449; WBGene00018754; WP:CE19449 F53C3.2 Aff_F53C3.2 fbxb-103; F53C3.2; 2E197; CE19440; WBGene00018746; WP:CE19440 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Murphy et al 2003 Fig2 Class2 shorten lifespan F53F8.5 Aff_F53F8.5 F53F8.5; 5V168; CE17859; WBGene00010002; WP:CE17859 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes F53G2.1 Aff_F53G2.1 F53G2.1; 2C783; CE10990; WBGene00018766; WP:CE10990 ViswanathanM et al 2005 S2 daf-16 Resveratrol F53G2.6 Aff_F53G2.6 tsr-1; F53G2.6; 2C752; CE37021; NM_061878; WBGene00006647; WP:CE37021 tsr-1 encodes a homolog of human transportin-SR, a nuclear transport receptor, and affects embryonic viability. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol F53H2.3 Aff_F53H2.3 F53H2.3; 5U866; CE19888; WBGene00010006; WP:CE19888 F53H8.3 Aff_F53H8.3 F53H8.3; CE04656; WBGene00018779; WP:CE04656; XB557 glucose transporter Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F54A5.1 Aff_F54A5.E F54A5.1; F54A5.1.1; F54A5.1.2; F54A5.E; 1B465; CE20859; WBGene00018786; WP:CE20859 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Climbing, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 F54A5.2 Aff_F54A5.C F54A5.2; F54A5.C; 1B438; CE20860; WBGene00018787; WP:CE20860 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt herm enriched gen F54C9.1 Aff_F54C9.1 iff-2; F54C9.1; F54C9.1.1; F54C9.1.2; F54C9.1.3; 2I850; CE02249; NM_063406; WBGene00002065; WP:CE02249 initiation factor 5A McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F54D11.2 Aff_F54D11.2 F54D11.2; F54D11.2.1; F54D11.2.2; F54D11.2.3; 5F105; CE30805; WBGene00018812; WP:CE30805 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol F54E7.5 Aff_F54E7.5 sdz-21; F54E7.5; 3G744; CE01316; WBGene00018828; WP:CE01316 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F54E7.7 Aff_F54E7.7 rcn-1; F54E7.7; 3G772; CE31002; DSCR1L; NM_065822; SC; WBGene00004321; WP:CE31002 rcn-1 encodes a calcipressin, which binds and inhibits calcineurin; RCN-1's orthologs include yeast Rcn1p and human DSCR1 (OMIM:602917; overexpressed in Down syndrome and Alzheimer disease); rcn-1 is expressed in hypodermal seam cells, various neurons, vulval epithelial and muscle cells, marginal pharyngeal cells, and in the male tail; rcn-1 transcription is regulated by TAX-6, and RCN-1 binds TAX-6 protein if free Ca[2+] is present; RCN-1 overexpression, like calcineurin deficiency, causes defects in body size, cuticle thickness, fertility, growth rate, and serotonin-resistance in egg-laying. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F54H12.3 Aff_F54H12.3 F54H12.3; 3J48; CE00545; WBGene00018843; WP:CE00545 ViswanathanM et al 2005 S2 sir-2.1 regulated F55A4.8 Aff_F55A4.8 F55A4.8; F55A4.8c.1; F55A4.8c.2; CE19463; CE31182; CE31183; WBGene00018860; WP:CE19463; WP:CE31182; WP:CE31183; XB658 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B F55A8.1 Aff_Y48A5B.B egl-18; elt-5; pvl-3; F55A8.1; F55A8.1.1; F55A8.1.2; F55A8.1.3; 4C681; CE28339; NM_067742; WBGene00001186; WP:CE28339 egl-18 encodes a member of the GATA-family of transcription factors that affects cell migration, cell fate specification; expressed in the head, in hypodermal seam cells, VC neurons, and vulval precursor cells. zinc finger protein Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F55B11.1 Aff_F55B11.1 F55B11.1; 4P166; CE16116; WBGene00010083; WP:CE16116 The F55B11.1 gene encodes an ortholog of the human gene XANTHINE DEHYDROGENASE (XDH), which when mutated leads to xanthinuria (OMIM:278300). xanthine dehydrogenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated F55B12.5 Aff_F55B12.5 nrf-5; F55B12.5; F55B12.5.1; F55B12.5.2; 5O309; CE32438; NM_074023; WBGene00003812; WBGene00010090; WP:CE32438 F55C10.2 Aff_F55C10.2 col-154; F55C10.2; 5L865; CE05952; NM_073485; WBGene00000727; WP:CE05952 collagen Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F55C9.1 Aff_F55C9.1 fbxb-117; F55C9.1; 5T759; CE18733; WBGene00010099; WP:CE18733 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F55C9.10 Aff_F55C9.10, Aff_Y116F11.H fbxb-61; F55C9.10; 5T775; CE18742; WBGene00010106; WP:CE18742 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F55C9.13 Aff_F55C9.9 fbxb-63; F55C9.13; F55C9.9; CE18741; WBGene00044197; WP:CE18741 ViswanathanM et al 2005 S2 sir-2.1 regulated F55C9.3 Aff_F55C9.3 F55C9.3; 5T762; CE18735; WBGene00010100; WP:CE18735 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F55C9.4 Aff_F55C9.4 fbxb-57; F55C9.4; 5T763; CE18736; WBGene00010101; WP:CE18736 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F55C9.5 Aff_F55C9.5 F55C9.5; 5T764; CE18737; WBGene00010102; WP:CE18737 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F55C9.7 Aff_F55C9.7, Aff_Y116F11.F fbxb-60; F55C9.7; 5T771; CE18739; WBGene00010104; WP:CE18739 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F55D12.1 Aff_F55D12.1 F55D12.1; 1I459; CE05955; WBGene00010110; WP:CE05955 Jones et al 2001 Non dauer genes P<0.05 F55G7.2 Aff_F55G7.2 F55G7.2; CE03424; WBGene00010120; WP:CE03424; XM546 F56A11.3 Aff_F56A11.3 efn-4; mab-26; F56A11.3; 4B319; CE29503; NM_067546; WBGene00001165; WP:CE29503 efn-4 encodes a member of the ephrin family of ligands that affects neuroblast migrations during closure of the ventral gastrulation cleft and subsequent epidermal morphogenesis, possibly functioning independently of EFN-1, EFN-2, EFN-3, and the VAB-1 receptor during morphogenesis; can interact with VAB-1 in vitro, and is expressed in neural and epidermal precursors at the 100-cell stage, in head neurons, pharyngeal cells, lateral and tail neurons, and in the ectoderm during epidermal enclosure. Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order F56A12.1 Aff_F56A12.1 mig-3; unc-39; F56A12.1; 5O855; CE37921; NM_074162; WBGene00006775; WP:CE37921 unc-39 encodes a homeodomain transcription factor that belongs to the Six4/5 family of homeodomain proteins that includes human Six5; UNC-39 is required for axonal pathfinding in anterior-derived neurons and for specification of most mesodermal cell types and may regulate a developmental decision between migration and differentiation; UNC-39 is expressed in the embryo in anterior neurons, posteriorly derived mesoderm (somatic gonad, M mesoblast, and possibly the coelomocytes and muIntR), the CAN neurons, and body wall muscle. so class homeobox protein ViswanathanM et al 2005 S2 sir-2.1 regulated F56A6.2 Aff_F56A6.2 hum-7; F56A6.2; 1B60; CE23779; NM_058354; WBGene00002040; WP:CE23779 hum-7 encodes a class IX unconventional myosin heavy chain that contains a myosin motor domain in the head region and zinc-finger and rhoGAP (rho GTPase activating protein) domains in the tail region; HUM-7 is required during embryogenesis for cytokinesis and normal cytoplasmic rearrangements, and by homology, may function in organization of the actin cytoskeleton; the precise expression and localization patterns of HUM-7 are not yet known. myosin ViswanathanM et al 2005 S2 sir-2.1 regulated F56B3.10 Aff_F56B3.10 gst-40; F56B3.10; 4B515; CE27168; NM_067580; WBGene00001788; WP:CE27168 glutathione S-transferase Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated F56B3.2 Aff_F56B3.2 F56B3.2; 4B518; CE29402; CE31545; WBGene00018928; WP:CE29402; WP:CE31545 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56B3.4 Aff_F56B3.4 skr-18; F56B3.4; 4B540; CE29969; CE37243; WBGene00004824; WP:CE29969; WP:CE37243 skr-18 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-18 has no known function in vivo, since skr-18(RNAi) animals are at least superficially normal. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA F56B3.7 Aff_F56B3.7 ugt-52; F56B3.7; 4B535; CE23781; WBGene00018931; WP:CE23781 7TM chemoreceptor, ugt family ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F56C11.6 Aff_F56C11.6 F56C11.6; 1A647; CE17905; CE33402; WBGene00018958; WP:CE17905; WP:CE33402 carboxylesterases McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, list of genes in cluster D, ViswanathanM et al 2005 S2 sir-2.1 regulated F56F4.1 Aff_F56F4.1 sdz-22; F56F4.1; 1G727; CE39020; WBGene00018978; WP:CE39020 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F56H1.3 Aff_C04F1.3 F56H1.3; 1G306; CE17914; WBGene00018994; WP:CE17914 Reinke et al 2004, herm sperm, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F56H6.2 Aff_F56H6.2 F56H6.2; 1M871; CE28567; WBGene00010163; WP:CE28567 F57C12.5 Aff_F57C12.5 mrp-1; sdf-14; F57C12.5; F57C12.5d.1; F57C12.5d.2; F57C12.5d.3; CE25015; CE29412; CE31189; CE34565; CE39102; NM_075721; WBGene00003407; WP:CE25015; WP:CE29412; WP:CE31189; WP:CE34565; WP:CE39102; XB196 ABC transporter McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F57F4.2 Aff_F57F4.2 F57F4.2; 5G868; CE11340; WBGene00019016; WP:CE11340 Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F57F4.3 Aff_F57F4.3 gfi-1; F57F4.3; 5G882; CE11342; NM_072225; WBGene00001581; WP:CE11342 gfi-1 encodes a protein that contains 21 ET modules; interacts with unc-68 in yeast two-hybrid assays. Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C F57G12.1 Aff_F57G12.1 F57G12.1; F57G12.1.1; F57G12.1.2; CE03426; WBGene00010221; WP:CE03426; XM788 Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated F57G8.8 Aff_F57G8.2 srv-36; F57G8.8; 5Q806; CE35184; NM_074725; WBGene00005747; WP:CE35184 ViswanathanM et al 2005 S2 sir-2.1 regulated F57G9.3 Aff_F57G9.3 F57G9.3; 2M700; CE17919; WBGene00010219; WP:CE17919 F58A6.1 Aff_F58A6.1 F58A6.1; 2F429; CE04675; WBGene00019022; WP:CE04675 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated F58D2.1 Aff_F58D2.1 F58D2.1; 4N951; CE18782; WBGene00010240; WP:CE18782 C.elegans ZYG-11 protein like Romagnolo et al 2002 Fig3b others F58E1.10 Aff_F58E1.10 F58E1.10; 2B980; CE11390; WBGene00019041; WP:CE11390 Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated F58E1.11 Aff_F58E1.11 F58E1.11; 2B982; CE36171; WBGene00019042; WP:CE36171 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 daf-16 Resveratrol F58E1.12 Aff_F58E1.12 F58E1.12; 2B984; CE11394; WBGene00019043; WP:CE11394 Reinke et al 2004, list of genes in cluster order, Romagnolo et al 2002 Fig3b Unkown F58E1.14 Aff_F58E1.14 fbxb-47; F58E1.14; 2B992; CE11398; WBGene00019045; WP:CE11398 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol F58E1.3 Aff_F58E1.3 fbxb-26; F58E1.3; 2B971; CE11376; WBGene00019035; WP:CE11376 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated F58E1.5 Aff_F58E1.5 fbxb-17; F58E1.5; 2B965; CE11380; WBGene00019037; WP:CE11380 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F58E1.8 Aff_F58E1.8 fbxb-18; F58E1.8; 2B974; CE11386; WBGene00019039; WP:CE11386 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains leucine-rich repeats. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol F58E1.9 Aff_F58E1.9 fbxb-19; F58E1.9; 2B976; CE11388; WBGene00019040; WP:CE11388 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated F58E10.2 Aff_F58E10.2 end-1; F58E10.2; 5O467; CE18784; NM_074074; WBGene00001310; WP:CE18784 end-1 encodes a GATA-like transcription factor sufficient to initiate endoderm differentiation and binds to the canonical target DNA sequence WGATAR with specificity similar to GATA-1 and D4 transcription factors; its expression bypasses requirement for maternal SKN-1 and the maternal Wnt signaling pathway in endoderm formation and it activates endoderm differentiation in isolated Xenopus ectoderm. GATA family of transcription factors Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 F58E10.5 Aff_F58E10.5 end-3; F58E10.5; 5O495; CE18787; NM_074079; WBGene00001311; WP:CE18787 end-3 encodes a GATA zinc finger protein, paralogous to end-1, that helps specify mesoendodermal (as opposed to mesectodermal) lineages derived from the E blastomere. GATA family of transcription factors F58E10.7 Aff_F58E10.7 F58E10.7; 5O473; CE18789; WBGene00010262; WP:CE18789 Reinke et al 2004, IVb male soma enriched genes, Romagnolo et al 2002 Fig3b Unkown, Romagnolo et al 2002 Fig5 genes in let-60 timecour, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 F58G1.4 Aff_F58G1.4 F58G1.4; 2N223; CE17924; WBGene00010266; WP:CE17924 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C F58G4.4 Aff_F58G4.4 sdz-23; F58G4.4; 5I575; CE07309; WBGene00019066; WP:CE07309 F58G6.1 Aff_F58G6.1 F58G6.1; F58G6.1.1; F58G6.1.2; 4K410; CE03428; WBGene00010272; WP:CE03428 amphiphysin like McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph F58H1.5 Aff_F58H1.5 F58H1.5; F58H1.5.1; F58H1.5.2; 5M441; CE06029; WBGene00010288; WP:CE06029 F58H7.7 Aff_F58H7.7 F58H7.7; 4B667; CE34326; WBGene00019072; WP:CE34326 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. F59A1.10 Aff_F59A1.10 F59A1.10; 5S141; CE18794; WBGene00010296; WP:CE18794 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen F59F5.8 Aff_F59F5.2 F59F5.8; CE26716; WBGene00010346; WP:CE26716 F59G1.5 Aff_F59G1.5 ptp-2; stp-1; F59G1.5; F59G1.5.1; F59G1.5.2; 2G211; CE02705; NM_062783; WBGene00004214; WP:CE02705 PROTEIN-TYROSINE PHOSPHATASE McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA H10E21.1 Aff_H10E21.1 H10E21.1; 3A635; CE32456; WBGene00019182; WP:CE32456 H12C20.3 Aff_H12C20.3 nhr-68; H12C20.3; 5M55; CE18808; NM_073535; WBGene00003658; WP:CE18808 nuclear hormone receptor Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated H12D21.8 Aff_H12D21.8 H12D21.8; 5P385; CE19921; WBGene00010384; WP:CE19921 H20J04.6 Aff_H20J04_717.A H20J04.6; H20J04.B; 2E613; CE20973; WBGene00019221; WP:CE20973 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated H24O09.2 Aff_H24O09.B fbxb-72; H24O09.2; 5B202; CE23825; WBGene00019243; WP:CE23825 Reinke et al 2004, male sperm, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, mixed sperm soma, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, fem3 enriched genes H28G03.1 Aff_H28G03.1 H28G03.1; H28G03.1a.1; H28G03.1a.2; H28G03.1c.1; H28G03.1c.2; CE30079; CE30080; CE31190; WBGene00019249; WP:CE30079; WP:CE30080; WP:CE31190; XF837 RNA binding protein ViswanathanM et al 2005 S2 sir-2.1 regulated H32C10.2 Aff_H32C10.B H32C10.2; 4G697; CE21004; WBGene00019256; WP:CE21004 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B H38K22.1 Aff_H38K22.1 evl-14; H38K22.1; 3F394; CE33526; NM_065464; WBGene00001352; WP:CE33526 evl-14 encodes a homolog of the yeast sister cohesion protein Pds5p that functions during both mitosis and meiosis and is implicated in the maintenance of sister chromatid cohesion in late prophase, and affects vulval morphology, meiotic germline development, embryonic and larval viability, fertility, and cell divisions in the germ line as well as in vulval and somatic gonad lineages; some of the defects, such as somatic gonad defects, are due at least partially to cell division defects. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K01D12.14 Aff_K01D12.14 cdr-5; K01D12.14; 5M888; CE38390; NM_073710; WBGene00010473; WP:CE38390 K02B12.2 Aff_K02B12.2 K02B12.2; 1J88; CE06063; WBGene00010495; WP:CE06063 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K02D3.1 Aff_K02D3.1 K02D3.1; CE06069; WBGene00010504; WP:CE06069; XO323 K02D7.1 Aff_K02D7.1 K02D7.1; 4B46; CE17994; WBGene00019298; WP:CE17994 K02D7.1 is orthologous to the human gene PURINE NUCLEOSIDE PHOSPHORYLASE (NP; OMIM:164050), which when mutated leads to disease. phosphorylase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated K02E10.2 Aff_K02E10.2 hid-1; K02E10.2; CE04694; CE34327; NM_076053; WBGene00001844; WP:CE04694; WP:CE34327; XD111 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph K02E2.4 Aff_K02E2.4 ins-35; K02E2.4; 5U845; CE18839; NM_075525; WBGene00002118; WP:CE18839 ins-35 encodes one of several insulin-related peptides. Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order K02E7.6 Aff_K02E7.6 K02E7.6; K02E7.6.1; K02E7.6.2; 2B349; CE33417; WBGene00019311; WP:CE33417 Reinke et al 2004, IVb male soma enriched genes, Shen et al 2005 T1 hif-1 depend hypoxia, ViswanathanM et al 2005 S2 sir-2.1 regulated K02E7.9 Aff_K02E7.9 K02E7.9; 2B350; CE11638; WBGene00019313; WP:CE11638 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K02F2.6 Aff_K02F2.6 ser-3; K02F2.6; 1H400; CE17158; NM_059553; WBGene00004778; WP:CE17158 ser-3 encodes a predicted G protein-coupled receptor that is a candidate metabotropic serotonin receptor; SER-3 activity is required for fertility and for embryonic development; to date, SER-3 expression has been detected in the pharynx. seven trans-membrane receptor ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 K02F3.4 Aff_K02F3.4 zip-2; K02F3.4; K02F3.4.1; K02F3.4.2; 3B453; CE23848; WBGene00019327; WP:CE23848 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K02G10.8 Aff_K02G10.8 dnj-14; K02G10.8; CE04708; NM_076405; WBGene00001032; WP:CE04708; XF330 This gene encodes a protein containing a DnaJ ('J') domain. Lund et al 2002 Fig3B neuro-specific genes, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated K05C4.9 Aff_K05C4.9, Aff_Y105E8A.MM K05C4.9; 1P318; CE19977; WBGene00010585; WP:CE19977 Leucine Rich Repeat (2 copies) (3 domains) Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT K05F1.5 Aff_K05F1.4 K05F1.5; 2G83; CE28587; WBGene00019407; WP:CE28587 K05F6.1 Aff_K05F6.1 fbxb-49; K05F6.1; 2B861; CE17159; WBGene00019412; WP:CE17159 ViswanathanM et al 2005 S2 daf-16 Resveratrol K05F6.4 Aff_K05F6.4 K05F6.4; 2B837; CE17162; WBGene00019415; WP:CE17162 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated K05F6.7 Aff_K05F6.7 fbxb-54; K05F6.7; 2B846; CE28588; WBGene00019418; WP:CE28588 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol K05F6.9 Aff_K05F6.9 fbxb-46; K05F6.9; 2B858; CE17167; WBGene00019420; WP:CE17167 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 daf-16 Resveratrol K07C11.4 Aff_K07C11.4 K07C11.4; 5I685; CE07347; WBGene00019477; WP:CE07347 esterase Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Zhang et al 2002, T1 mec-3 dependent genes K07C5.5 Aff_K07C5.5 K07C5.5; 5K836; CE06115; WBGene00010628; WP:CE06115 hydrolase ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 K07C6.5 Aff_K07C6.5 cyp-35A5; K07C6.5; 5E415; CE17176; NM_071691; WBGene00019473; WP:CE17176 cytochrome P450 ReichertK et al 2005 T1 xenobiotic induced P450 K07F5.1 Aff_K07F5.1 msp-81; K07F5.1; 4K600; NM_069358; WBGene00003467 msp-81 encodes a member of the major sperm protein family. major sperm protein K07F5.2 Aff_K07F5.2 msp-10; K07F5.2; 4K603; CE03853; NM_069359; WBGene00003425; WP:CE03853 msp-10 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm K08A8.2 Aff_K08A8.2 sox-2; K08A8.2; K08A8.2a.1; K08A8.2a.2; K08A8.2b.1; K08A8.2b.2; K08A8.2b.3; CE28595; CE31200; NM_171725; NM_171726; WBGene00004949; WP:CE28595; WP:CE31200; XI78 The sox-2 gene encodes a homolog of human SRY, which when mutated leads to gonadal dysgenesis (OMIM:306100). K08B12.2 Aff_K08B12.2 K08B12.2; 5G731; CE29814; CE30817; WBGene00019521; WP:CE29814; WP:CE30817 K08B4.2 Aff_K08B4.2 K08B4.2; 4G840; CE25940; WBGene00019514; WP:CE25940 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 daf-16 Resveratrol K08B4.4 Aff_K08B4.4 ugt-20; K08B4.4; 4G846; CE18033; WBGene00019516; WP:CE18033 7TM chemoreceptor, ugt family Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order K08B5.1 Aff_K08B5.1 K08B5.1; CE35740; WBGene00019518; WP:CE35740; XR175 Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K08C7.3 Aff_K08C7.3 egf-3; epi-1; lgx-3; K08C7.3; 4L443; CE06136; CE25049; NM_069569; WBGene00001328; WP:CE06136; WP:CE25049 epi-1 encodes a laminin alpha chain that affects oogenesis due to its affect on gonad development, and also affects cell migrations, axon extension and GABAergic defasciculation, morphology of the VD and DD motor neurons, body morphology, locomotion, gonad sheath epithelialization, body muscle structure, and germ cell proliferation. laminin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K08D10.8 Aff_K08D10.8 K08D10.8; K08D10.8.1; K08D10.8.2; 4E929; CE07360; WBGene00019531; WP:CE07360 K08D10.7 encodes a homolog of human scramblase (PLSCR1; OMIM:604170), which is activated by a rise of intracellular calcium, and which promotes the exposure of phosphatidylserine on the surface of cells undergoing activation, injury, or apoptosis; a close paralog of K08D10.8 is K08D10.7, and other paralogs include F46A8.9, F46A8.10, and Y50E8A.9> Exposure of phosphatidylserine on the surface of apoptotic cells occurs because of a phospholipid scramblase and inactivation of an aminophospolipid translocase that would normally keep the PS on the interior of the cell; by virtue of its similarity to mammalian scramblase, K08D10.8 may promote clearage of apoptotic cells by phagocytosis. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 sir-2.1 regulated K08F4.8 Aff_K08F4.8 msp-38; K08F4.8; 4K908; CE06156; NM_069448; WBGene00003434; WP:CE06156 msp-38 encodes a member of the major sperm protein family; msp-38 has a C. briggsae homolog as predicted by the Wobble Bulk Aware Bulk Aligner (WABA). major sperm protein MSP-38 K09C4.8 Aff_K09C4.8 sul-1; tag-37; K09C4.8; CE04736; NM_076159; WBGene00006308; WP:CE04736; XD886 sul-1 encodes a member of the sulfatase family. sulfatase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 K09C6.6 Aff_K09C6.6 K09C6.6; 5B323; CE11998; WBGene00019560; WP:CE11998 K09E2.4 Aff_K09E2.4 rig-1; K09E2.4; CE02817; CE34053; WBGene00004369; WP:CE02817; WP:CE34053; XJ289 K09F6.8 Aff_K09F6.8 K09F6.8; 2C584; CE12038; WBGene00019591; WP:CE12038 ViswanathanM et al 2005 S2 sir-2.1 regulated K09H11.1 Aff_K09H11.1 K09H11.1; 5G231; CE21068; WBGene00019599; WP:CE21068 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 Resveratrol regulate WT K09H9.7 Aff_K09H9.7 K09H9.7; 1D718; CE39596; WBGene00019598; WP:CE39596 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated K10B3.1 Aff_K10B3.1 K10B3.1; CE07364; CE37127; WBGene00019609; WP:CE07364; WP:CE37127; XD755 K10D2.7 Aff_K10D2.7 K10D2.7; 3G285; CE02019; WBGene00019633; WP:CE02019 Jones et al 2001 Dauer specific genes P<0.05, Wang et al 2003 S8 SAGE genes in the dauer exit K11D2.3 Aff_K11D2.3 unc-101; K11D2.3; K11D2.3.1; K11D2.3.2; 1N105; CE28050; NM_060773; WBGene00006829; WP:CE28050 unc-101 encodes an adaptin orthologous to the mu1-I subunit of adaptor protein complex 1 (AP-1) that is involved in motility, egg-laying, negative regulation of LET-23 / EGF-receptor signalling, and localization of the neuronal receptors ODR-10 and GLR-1; it is broadly expressed. K11G9.1 Aff_K11G9.1 K11G9.1; 5H159; CE07374; WBGene00019652; WP:CE07374 esterase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 K12B6.1 Aff_K12B6.1 K12B6.1; 5G787; CE12164; WBGene00019666; WP:CE12164 K12F2.2 Aff_K12F2.2 klp-5; unc-107; vab-8; K12F2.2; 5M705; CE23870; CE31041; NM_073662; NM_073663; WBGene00006874; WP:CE23870; WP:CE31041 The vab-8 gene encodes a novel protein containing an atypical kinesin-like motor domain that is required for many posteriorly-directed cell migrations, as well as axonal outgrowth and pathfinding; vab-8 encodes two protein isoforms: VAB-8S, a novel protein expressed in migrating cells, and VAB-8L, which contains a kinesin-related domain, is expressed in neurons and functions in growth cone migrations; VAB-8 interacts with UNC-51, a serine-threonine kinase also required for axon outgrowth. kinesin-like protein K12H6.11 Aff_K12H6.11 K12H6.11; 2D109; CE20014; WBGene00019690; WP:CE20014 K12H6.7 Aff_K12H6.7 K12H6.7; 2D126; CE20010; WBGene00019687; WP:CE20010 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol M01D1.1 Aff_M01D1.1 str-148; M01D1.1; 2B337; CE21071; NM_061497; WBGene00006195; WP:CE21071 7TM chemoreceptor, str family M01D1.3 Aff_F45D11_40.A, Aff_M01D1.3 M01D1.3; 2B314; CE23871; WBGene00019700; WP:CE23871 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol M01D1.8 Aff_M01D1.8 fbxb-41; M01D1.8; 2B332; CE12256; WBGene00019703; WP:CE12256 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E M01D1.9 Aff_M01D1.9 fbxb-40; M01D1.9; 2B340; CE12258; WBGene00019704; WP:CE12258 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. M01D7.1 Aff_M01D7.1 M01D7.1; 1C330; CE12260; WBGene00019706; WP:CE12260 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 daf-16 Resveratrol M01D7.2 Aff_M01D7.2 scm-1; M01D7.2; 1C336; CE25946; NM_058510; SCAMP; WBGene00004743; WP:CE25946 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph M01E5.6 Aff_M01E5.6 M01E5.6; 1N890; CE12286; WBGene00010808; WP:CE12286 ViswanathanM et al 2005 S2 daf-16 Resveratrol M01H9.4 Aff_M01H9.4 M01H9.4; 4F244; CE39601; WBGene00019720; WP:CE39601 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order M02A10.3 Aff_M02A10.3 sli-1; M02A10.3; CE25058; CE27393; CE37131; NM_075744; WBGene00004829; WP:CE25058; WP:CE27393; WP:CE37131; XB340 adaptor-like E3 ubiquitin ligase ViswanathanM et al 2005 S2 sir-2.1 regulated M03A1.1 Aff_M03A1.1 vab-1; M03A1.1; 2E879; CE25060; CE28617; NM_062405; NM_062406; WBGene00006868; WP:CE25060; WP:CE28617 tyrosine-protein kinase receptor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol M03A8.1 Aff_M03A8.1 dhs-28; M03A8.1; CE04770; NM_076745; WBGene00000991; WP:CE04770; XH437 dhs-28 encodes an ortholog of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE 4 (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), which contains a C-terminal SCP-2 sterol transfer domain; the deletion allele dhs-28(ok450) is superficially wild-type. alcohol dehydrogenase; non-specific lipid transfer protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated M03A8.2 Aff_M03A8.2 M03A8.2; CE30679; WBGene00019748; WP:CE30679; XH435 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph M04B2.5 Aff_M04B2.5 M04B2.5; 4M273; CE36554; NM_069769; WBGene00006678; WP:CE36554 potassium channel protein Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated M05D6.7 Aff_M05D6.7 gbh-2; M05D6.7; 2I777; CE35896; NM_063392; WBGene00001523; WP:CE35896 gbh-2 encodes an ortholog of human gamma butyrobetaine hydroxilase 2 involved in carnitine biosynthesis; RNA interference of gbh-2 results in malformation of the gonad and accumulation of fat in the pseudocoelomic cavity and in intestinal cells; the GBH-2-GFP fusion protein is predominantly expressed in intestinal cells from early embryogenesis. gamma-butyrobetaine,2-oxoglutarate dioxygenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph M110.4 Aff_M110.4 ifg-1; M110.4; 2I511; CE02277; CE35745; WBGene00002066; WP:CE02277; WP:CE35745 ifg-1 encodes, by alternative splicing, two orthologs of the translational initiation factor eIF4 (eIF-4) gamma. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph M117.5 Aff_M117.5 fbxb-4; M117.5; 4M595; CE18086; WBGene00010921; WP:CE18086 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 daf-16 Resveratrol M151.5 Aff_M151.5 fbxb-31; M151.5; 2D922; CE12442; WBGene00019797; WP:CE12442 ViswanathanM et al 2005 S2 daf-16 Resveratrol M151.8 Aff_M151.6 fbxb-33; M151.8; CE38623; WBGene00044314; WP:CE38623 M153.1 Aff_M153.1 M153.1; CE03511; WBGene00010924; WP:CE03511; XM767 pyrroline-5-carboxylate reductase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig3b Metabolism, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 LateList M163.3 Aff_M163.3 his-24; M163.3; CE12450; HH1; NM_078009; WBGene00001898; WP:CE12450; XP109 The his-24 gene encodes a histone H1 isoform (H1.1) that is essential for chromatin silencing and germline development. histone H1 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, IVb male soma enriched genes R02C2.1 Aff_R02C2.1 R02C2.1; 5A716; CE33150; WBGene00019814; WP:CE33150 protein kinase ViswanathanM et al 2005 S2 daf-16 Resveratrol R03E9.1 Aff_R03E9.1 mdl-1; R03E9.1; CE04784; NM_076735; WBGene00003163; WP:CE04784; XH361 human Max-interacting bHLH-Zip protein Murphy et al 2003 Fig2 Class1 elongate lifespan, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 R03E9.2 Aff_R03E9.2 R03E9.2; CE04785; WBGene00019843; WP:CE04785; XH350 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 R04B3.2 Aff_R04B3.2 R04B3.2; CE28745; WBGene00019867; WP:CE28745; XD90 The R04B3.2 gene encodes an ortholog of the human gene LYSOSOMAL GLYCOSYLASPARAGINASE (AGA; OMIM:208400), which when mutated leads to aspartylglucosaminuria (OMIM:208400). glycosylasparaginase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R04B5.5 Aff_R04B5.5 R04B5.5; 5K569; CE06215; WBGene00011003; WP:CE06215 sorbitol dehydrogenase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol R05D3.9 Aff_R05D3.9 R05D3.9; 3J452; CE31049; WBGene00019882; WP:CE31049 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 R06A4.6 Aff_R06A4.6 sdz-26; R06A4.6; 2O669; CE18113; WBGene00011049; WP:CE18113 similar to PES-10 Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol R06C7.3 Aff_R06C7.3 CeCRMP/DHP-1; dhp-1; R06C7.3; R06C7.3.1; R06C7.3.2; 1H816; CE30293; NM_170899; WBGene00000963; WP:CE30293 The R06C7.3 gene encodes a homolog of the human gene DPYS, which when mutated leads to dihydropyrimidinuria (OMIM:222748). dihydropyrimidinase R06F6.6 Aff_R06F6.6 R06F6.6; 2L101; CE01622; WBGene00011069; WP:CE01622 Homeobox domain ViswanathanM et al 2005 S2 daf-16 Resveratrol R07B5.9 Aff_R07B5.8 R07B5.9; CE31575; WBGene00011086; WP:CE31575 R07C3.11 Aff_R07C3.11 R07C3.11; 2B196; CE12542; WBGene00019927; WP:CE12542 Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol R07C3.5 Aff_R07C3.5 R07C3.5; 2B217; CE12530; WBGene00019921; WP:CE12530 R07C3.6 Aff_R07C3.6 R07C3.6; 2B213; CE12532; WBGene00019922; WP:CE12532 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R07C3.7 Aff_R07C3.7 R07C3.7; 2B207; CE12534; WBGene00019923; WP:CE12534 ViswanathanM et al 2005 S2 sir-2.1 regulated R07C3.9 Aff_R07C3.9 R07C3.9; 2B203; CE12538; WBGene00019925; WP:CE12538 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R07G3.1 Aff_R07G3.1 cdc-42; R07G3.1; R07G3.1.1; R07G3.1.2; 2H907; CE02020; NM_063197; WBGene00000390; WP:CE02020 The cdc-42 gene encodes a RHO GTPase which controls polarity of both individual cells and developing embryos by regulating the localization of PAR proteins; it is expressed at hypodermal cell boundaries. RAS protein McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R07H5.4 Aff_R07H5.4 sdz-27; R07H5.4; 4L953; CE12556; WBGene00011124; WP:CE12556 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination R07H5.9 Aff_R07H5.9 R07H5.9; 4L975; CE39953; WBGene00011129; WP:CE39953 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 R08B4.2 Aff_R08B4.2 alr-1; sns-10; R08B4.2; CE03536; WBGene00011138; WBGene00044330; WP:CE03536; XL742 homeobox protein (otd subfamily) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol R08E3.4 Aff_R08E3.4 R08E3.4; CE37662; CE37663; WBGene00019960; WP:CE37662; WP:CE37663; XF426 C2H2-type zinc finger McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol R08E5.3 Aff_R08E5.3 R08E5.3; R08E5.3.1; R08E5.3.2; 5E251; CE12576; WBGene00019963; WP:CE12576 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R09F10.4 Aff_R09F10.4 inx-5; opu-5; R09F10.4; CE33811; NM_077002; WBGene00002127; WP:CE33811; XI916 inx-5 encodes a predicted member of the innexin family; expressed in the embryonic hypodermis, developing vulva, seam cells, and spermatheca. unc-7-like protein Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig3b Transporters, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 R09H10.3 Aff_R09H10.3 R09H10.3; 4L369; CE34083; WBGene00011181; WP:CE34083 R09H10.3 is orthologous to the human gene TRANSTHYRETIN (PREALBUMIN, AMYLOIDOSIS TYPE I) (TTR; OMIM:176300), which when mutated leads to disease. ViswanathanM et al 2005 S2 sir-2.1 regulated R107.1 Aff_R107.1 indy-3; nac-2; nat-1; R107.1; R107.1.1; R107.1.2; 3K130; CE33536; NM_066599; WBGene00003518; WP:CE33536 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol R10D12.1 Aff_R10D12.1 R10D12.1; 5O414; CE12672; WBGene00011185; WP:CE12672 sodium/phosphate transporter Reinke et al 2004, IVb male soma enriched genes, Shen et al 2005 T1 hif-1 depend hypoxia, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 R10E11.1 Aff_R10E11.1 cbp-1; cep-1; R10E11.1; 3K863; CE21117; CE28069; NM_066759; NM_066760; WBGene00000366; WP:CE21117; WP:CE28069 cbp-1 encodes a homolog of the mammalian transcriptional cofactors CBP (OMIM:600140) and p300 (E1A-BINDING PROTEIN, 300-KD; OMIM:602700) that have been shown to possess histone acetyltransferase activity, and which, when mutated, lead to Rubinstein-Taybi syndrome (OMIM:180849) and colorectal cancer (OMIM:114500); at least one splicing form of CBP-1 exhibits histone acetyltransferase (HAT) activity in vitro and has a glutamine/asparagine-rich domain; CBP-1 is required during embryogenesis for differentiation of all non-neuronal somatic cell types; CBP-1 is expressed very early in embryogenesis, suggesting that it may interact with maternally provided transcription factors, such as SKN-1, to specific developmental fates. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph R11A5.3 Aff_R11A5.3 R11A5.3; 1I438; CE12726; WBGene00011231; WP:CE12726 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R11B5.1 Aff_R11B5.1 tag-236; R11B5.1; CE28759; WBGene00020002; WBGene00044061; WP:CE28759; XD144 R11D1.11 Aff_R11D1.11 dhs-21; R11D1.11; 5N212; CE39954; NM_073781; WBGene00000984; WP:CE39954 dhs-21 encodes a member of the short-chain dehydrogenases/reductases family (SDR) expressed in the intestine, hypodermis, uterus, and spermatheca. Mouse adipocyte P27 protein like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R11E3.2 Aff_R11E3.2 R11E3.2; 4F535; CE19544; WBGene00020004; WP:CE19544 permease McCarroll et al 2004 SFig1-4 conserved w/ Drosoph R11F4.1 Aff_R11F4.1 R11F4.1; R11F4.1.1; R11F4.1.2; 2E383; CE04828; WBGene00020007; WP:CE04828 The R11F4.1 gene encodes a homolog of human glycerol kinase (GK), which when mutated leads to hyperglycerolemia (glycerol kinase deficiency; OMIM:307030). Glycerol kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 R12C12.1 Aff_R12C12.1 R12C12.1; R12C12.1a.1; R12C12.1a.2; 2G343; CE02846; CE33434; WBGene00020022; WP:CE02846; WP:CE33434 R12C12.1 is orthologous to human GLYCINE DECARBOXYLASE (GLDC; OMIM:238300), which when mutated leads to glycine encephalopathy. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 R12E2.6 Aff_R12E2.6 R12E2.6; 1E720; CE18138; WBGene00020032; WP:CE18138 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated R12H7.2 Aff_R12H7.2 asp-4; R12H7.2; CE03567; NM_077790; WBGene00000217; WP:CE03567; XN838 asp-4 encodes an aspartyl protease homolog that is required, in parallel with ASP-3 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf). aspartyl protease McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated R12H7.3 Aff_R12H7.3 skr-19; R12H7.3; CE03568; NM_077792; WBGene00004825; WP:CE03568; XN842 The skr-19 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-19(RNAi) animals are at least superficially normal. RNA polymerase II elongation factor like ViswanathanM et al 2005 S2 sir-2.1 regulated R13A5.5 Aff_R13A5.5 ceh-13; R13A5.5; 3I647; CE28767; NM_066254; WBGene00000437; WP:CE28767 a homolog of Hox genes of labial/Hox1 type; affects viability, body shape and anterior patterning during embryogenesis, interacts genetically with hox genes; and is expressed in A, D, E and MS lineages in the early embryo, and in the anterior dorsal hypodermal cells, anterior body wall muscle cells, and in the cells of the prospective ventral nerve cord at the comma stage; and in the ventral nerve cord and and ventral and dorsal hypodermal cells in L1 larvae. Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S6 removed genes of contamination, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit R13D11.7 Aff_R13D11.7 R13D11.7; 5B266; CE12794; WBGene00020061; WP:CE12794 Lund et al 2002 Fig1 aging-regulated genes R144.4 Aff_R144.4 R144.4; 3G109; CE34587; CE34588; WBGene00020094; WP:CE34587; WP:CE34588 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R148.4 Aff_R148.4 R148.4; 3E261; CE12854; WBGene00020103; WP:CE12854 Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated R17.1 Aff_R17.1 fbxb-85; R17.1; 3L936; CE16314; WBGene00011267; WP:CE16314 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 daf-16 Resveratrol R52.1 Aff_R52.1 bath-16; sdz-28; R52.1; 2C421; CE12824; WBGene00020073; WP:CE12824 Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol R52.8 Aff_R52.8 math-36; R52.8; 2C404; CE12838; WBGene00020079; WP:CE12838 Jones et al 2001 Non dauer genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated R57.1 Aff_R57.1 R57.1; R57.1b.1; R57.1b.2; R57.1c.1; R57.1c.2; R57.1c.3; CE12844; CE30114; CE37270; WBGene00020082; WP:CE12844; WP:CE30114; WP:CE37270; XA925 trans-membrane protein McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T01B11.2 Aff_T01B11.2 T01B11.2; 4J214; CE12894; CE33686; WBGene00020139; WP:CE12894; WP:CE33686 aminotransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 T01C4.2 Aff_T01C4.2 odr-2; T01C4.2; 5H593; CE28348; CE28349; CE28350; WBGene00003849; WP:CE28348; WP:CE28349; WP:CE28350 odr-2 encodes three isoforms of a predicted membrane-associated protein related to the Ly-6 (leukocyte antigen-6) family of GPI (glycosylated phosphatidylinositol)-linked signaling proteins; ODR-2 activity is required for proper functioning of the AWC olfactory neurons and thus for chemotaxis in response to AWC-sensed odorants; ODR-2 is expressed at high levels in sensory neurons, motor neurons, and interneurons, where it appears to be enriched in axons. T01C8.1 Aff_T01C8.1 aak-2; T01C8.1; T01C8.1c.1; T01C8.1c.2; CE07458; CE31222; CE31223; NM_078309; NM_078310; WBGene00020142; WP:CE07458; WP:CE31222; WP:CE31223; XR417 aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of stressors and energy level signals, as well as daf-2-mediated insulin signaling, to positively regulate adult lifespan; in addition, genetic analysis with daf-16 mutants indicates that, in regulating lifespan, AAK-2 likely acts in parallel with DAF-16; aak-2 activity is also required for dauer formation of daf-2 mutant animals at high temperature, in a manner that does not appear to be dependent upon the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate. Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit T01C8.5 Aff_T01C8.5 T01C8.5; CE07462; WBGene00020146; WP:CE07462; XR406 aminotransferase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T01H10.8 Aff_T01H10.8 T01H10.8; CE03607; WBGene00011361; WP:CE03607; XM748 Yeast hypothetical protein YCR32 like Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T02C1.1 Aff_T02C1.1 T02C1.1; 3K337; CE00312; WBGene00011365; WP:CE00312 Zinc finger, C3HC4 type (RING finger) ViswanathanM et al 2005 S2 daf-16 Resveratrol T02G6.6 Aff_T02G6.6 T02G6.6; 1M413; CE18177; WBGene00011389; WP:CE18177 ViswanathanM et al 2005 S2 sir-2.1 regulated T03D3.1 Aff_T03D3.1 ugt-53; T03D3.1; 5D329; CE13068; WBGene00020182; WP:CE13068 7TM chemoreceptor, ugt family Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 T03D8.3 Aff_T03D8.3 sbt-1; T03D8.3; 5V298; CE18921; WBGene00011392; WP:CE18921 neuroendocrine protein 7B2 Jiang et al 2001 Fig1 male-enriched neuronal, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA T03D8.6 Aff_T03D8.6 T03D8.6; 5V288; CE37271; WBGene00011393; WP:CE37271 Gamma-glutamyltranspeptidase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T03E6.7 Aff_T03E6.7 cpl-1; T03E6.7; T03E6.7.1; T03E6.7.2; 5R74; CE16333; NM_074798; WBGene00000776; WP:CE16333 cpl-1 encodes a member of the cathepsin L-like cysteine protease family required for embryonic viability and normal growth; expressed in eggshells and throughout early embryos, accumulates in intestinal cells during late embryogenesis, and expressed in the cuticle, gonad, and pharynx later in development. cathepsin-like protease McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0, Wang et al 2003 S4 Dauer Enriched T04B8.3 Aff_T04B8.3 T04B8.3; 2A919; CE39176; WBGene00020205; WP:CE39176 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E T04D1.4 Aff_T04D1.4 tag-192; T04D1.4; 1F262; CE18196; WBGene00007053; WBGene00020213; WP:CE18196 helicase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T04D3.2 Aff_T04D3.2 sdz-30; T04D3.2; 1N899; CE13155; WBGene00011432; WP:CE13155 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T04G9.4 Aff_T04G9.4 T04G9.4; CE04885; WBGene00020215; WP:CE04885; XB393 B. subtilis sfp protein; Anabaena sp. HETI protein Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T05A10.1 Aff_T05A10.1 sma-9; T05A10.1; T05A10.1h.1; T05A10.1h.2; T05A10.1k.1; T05A10.1k.2; T05A10.1k.3; CE36395; CE36396; CE36397; CE36398; CE36399; CE36400; CE36401; CE36402; CE36403; CE36404; CE39627; NM_171771; NM_171772; WBGene00004862; WP:CE36395; WP:CE36396; WP:CE36397; WP:CE36398; WP:CE36399; WP:CE36400; WP:CE36401; WP:CE36402; WP:CE36403; WP:CE36404; WP:CE39627; XL401 sma-9 encodes, by alternative splicing, at least two large (~2000-residue) protein with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain; SMA-9 is orthologous to human HIVEP1 (OMIM:194540), HIVEP2 (OMIM:143054), and HIVEP3 (OMIM:606649), and to Drosophila SCHNURRI (FBgn0003396); SMA-9 proteins are required for growth to normally large body size. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated T05A7.3 Aff_T05A7.3 T05A7.3; 2E967; CE04889; WBGene00020221; WP:CE04889 T05B11.1 Aff_T05B11.1 T05B11.1; 5I231; CE07464; WBGene00020245; WP:CE07464 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, list of genes in cluster B T05B4.2 Aff_T05B4.2 nhr-57; T05B4.2; 5E613; CE13195; NM_071752; WBGene00003647; WP:CE13195 zinc finger protein Jones et al 2001 Dauer specific genes P<0.05, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit T05D4.2 Aff_T05D4.2 T05D4.2; 3O650; CE16342; WBGene00011475; WP:CE16342 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T05E7.1 Aff_T05E7.1 T05E7.1; 1G781; CE13231; WBGene00020258; WP:CE13231 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Early genes, Wang et al 2003 S4 genes pass two-wayANOVA P0 T05E7.5 Aff_T05E7.5 T05E7.5; 1G778; CE13239; NM_059386; WBGene00020261; WP:CE13239 Romagnolo et al 2002 Fig3b Cell Structure, ViswanathanM et al 2005 S2 sir-2.1 regulated T05H10.3 Aff_T05H10.3 T05H10.3; 2I340; CE01640; WBGene00011508; WP:CE01640 T06A10.2 Aff_C26C9.2 T06A10.2; 4R835; CE36609; WBGene00020285; WP:CE36609 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T06C10.4 Aff_T06C10.4 flp-10; T06C10.4; T06C10.4.1; T06C10.4.2; 4I635; CE04902; NM_068905; WBGene00001453; WP:CE04902 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T06E6.13 Aff_T06E6.13 fbxa-104; T06E6.13; 5P900; CE18215; WBGene00011542; WP:CE18215 ViswanathanM et al 2005 S2 sir-2.1 regulated T07C4.2 Aff_T07C4.2 tbx-8; T07C4.2; 3L437; CE36891; NM_066886; WBGene00006545; WP:CE36891 Brachyury Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes T07C4.8 Aff_T07C4.8 ced-9; T07C4.8; 3L427; CE25104; NM_066883; WBGene00000423; WP:CE25104 ced-9 is required for control of programmed cell death during development; it encodes the only C. elegans homolog of BCL-2. Apoptosis regulator proteins, Bcl-2 family Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T07D1.4 Aff_T07D1.4 fox-1; T07D1.4; T07D1.4.1; T07D1.4.2; CE25105; NM_076045; WBGene00001484; WP:CE25105; XD66 fox-1 encodes an RNA-binding protein of the RNA recognition motif (RRM) superfamily of ribonucleic acid binding proteins; during C. elegans development, FOX-1 functions redundantly with other numerator elements to effect proper dosage compensation in the early embryo; in influencing dosage compensation, FOX-1 likely acts via post-transcriptional regulation of xol-1 mRNA levels; in addition to its role in dosage compensation, fox-1 activity is also required for normal male mating behavior; Western analysis and lacZ reporter constructs indicate that FOX-1 is expressed throughout the life cycle, beginning at the 18-20-cell stage of embryogenesis and continuing on through larval stages and into adult hermaphrodites and males; while early embryonic expression of fox-1 is ubiquitous, postembryonic expression is limited to a subset of head and tail neurons. RNA-binding protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T07D3.7 Aff_T07D3.7 alg-2; T07D3.7; TO7D3.7; 2B167; CE13367; CE32063; NM_061436; NM_182192; WBGene00000106; WP:CE13367; WP:CE32063 alg-2 encodes a PAZ and PIWI-domain containing protein that is a member of the highly conserved eukaryotic RDE-1/AGO1/PIWI family of proteins that regulate posttranscriptional gene silencing (PTGS); ALG-2 functions with ALG-1 to control specific developmental timing events by positively regulating expression of small temporal RNAs (stRNAs) encoded by lin-4 and let-7; ALG-2 and ALG-1 are also required for RNAi in the germline, although they are not required for RNAi in the soma. ViswanathanM et al 2005 S2 sir-2.1 regulated T07E3.4 Aff_T07E3.4 T07E3.4; T07E3.4a.1; T07E3.4a.2; T07E3.4b.1; T07E3.4b.2; 3H989; CE01385; CE32717; WBGene00020315; WP:CE01385; WP:CE32717 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C T08B1.6 Aff_T08B1.6 T08B1.6; 5C451; CE27444; WBGene00020343; WP:CE27444 long-chain fatty-acid CoA ligase Romagnolo et al 2002 Fig3b Metabolism, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 T08B2.5 Aff_T08B2.6 T08B2.5; 1G795; CE13429; CE25984; CE26949; CE30298; CE33171; CE33172; CE38728; WBGene00020346; WP:CE13429; WP:CE25984; WP:CE26949; WP:CE30298; WP:CE33171; WP:CE33172; WP:CE38728 ViswanathanM et al 2005 S2 sir-2.1 regulated T08E11.5 Aff_T08E11.5 T08E11.5; 2C113; CE33448; WBGene00020361; WP:CE33448 T08E11.6 Aff_T08E11.6 fbxb-10; T08E11.6; 2C104; CE19573; WBGene00020362; WP:CE19573 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E T08G5.3 Aff_T08G5.3 T08G5.3; 5O506; CE18945; WBGene00011624; WP:CE18945 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 T08G5.9 Aff_T08G5.8 T08G5.9; 5O526; CE18949; WBGene00011628; WP:CE18949 ViswanathanM et al 2005 S2 sir-2.1 regulated T08H4.3 Aff_T08H4.3 ast-1; T08H4.3; 2E418; CE19576; WBGene00020368; WP:CE19576 ETS protein T09B4.4 Aff_T09B4.4 T09B4.4; 1G745; CE36196; WBGene00020378; WP:CE36196 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated T09B4.5 Aff_T09B4.5 T09B4.5; T09B4.5a.1; T09B4.5a.2; 1G733; CE13465; CE33175; WBGene00020379; WP:CE13465; WP:CE33175 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T10B10.3 Aff_T10B10.3 T10B10.3; T10B10.3.1; T10B10.3.2; CE06401; WBGene00011680; WP:CE06401; XP798 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol T10C6.10 Aff_T10C6.10 T10C6.10; 5Q517; CE16385; WBGene00011691; WP:CE16385 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated T10C6.12 Aff_T10C6.12 his-3; T10C6.12; 5Q521; CE04501; NM_074631; WBGene00001877; WP:CE04501 his-3 encodes an H2A histone; by homology, HIS-3 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-3 is a replication-dependent histone locus that resides in the HIS1 cluster on chromosome V. histone H2A Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated T10C6.14 Aff_T10C6.14 his-1; T10C6.14; 5Q523; CE03252; NM_074633; WBGene00001875; WP:CE03252 his-1 encodes an H4 histone; his-1 is contained within the histone gene cluster HIS1; transcript analysis suggests that it encodes the major class of H4 transcripts. histone H4 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 T11A5.5 Aff_T11A5.5 sdz-31; T11A5.5; 5K359; CE06411; WBGene00011704; WP:CE06411 ViswanathanM et al 2005 S2 sir-2.1 regulated T12D8.1 Aff_T12D8.1 tag-350; T12D8.1; 3O745; CE16398; WBGene00011729; WP:CE16398 PHD-finger. (2 domains), SET domain McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order T12G3.1 Aff_T12G3.1 T12G3.1; T12G3.1.1; T12G3.1.2; 4M801; CE37554; WBGene00011737; WP:CE37554 Drosphila REF (2)P like ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 T14F9.3 Aff_T14F9.3 T14F9.3; CE07499; WBGene00020509; WP:CE07499; XC843 T14F9.3 is orthologous to the human gene CERVICAL CANCER PROTO-ONCOGENE 7 (HEXB; OMIM:606873), which when mutated leads to disease. beta-hexosaminidase beta subunit McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T14F9.5 Aff_T14F9.5 hlh-7; lin-32; T14F9.5; CE33318; NM_076009; WBGene00003018; WP:CE33318; XC846 lin-32 encodes a basic helix-loop-helix transcription factor that is required for development of several types of neurons, including the touch receptor neurons and the male sensory ray neurons. hlh transcription factor ViswanathanM et al 2005 S2 sir-2.1 regulated T14G10.2 Aff_T14G10.2 pxf-1; ra-gef; T14G10.2; T14G10.2a.1; T14G10.2a.2; T14G10.2b.1; T14G10.2b.2; 4K930; CE28080; CE28081; PXF; WBGene00004254; WP:CE28080; WP:CE28081 cell division control protein 25 like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 daf-16 Resveratrol T14G8.2 Aff_T14G8.2 T14G8.2; CE03658; WBGene00011770; WP:CE03658; XN477 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. T15B7.5 Aff_T15B7.5 col-141; T15B7.5; 5H311; CE13656; NM_072334; WBGene00000714; WP:CE13656 collagen Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated T15H9.6 Aff_T15H9.6 T15H9.6; 2J898; CE01669; WBGene00011791; WP:CE01669 poly(A) polymerase ViswanathanM et al 2005 S2 daf-16 Resveratrol T16A1.8 Aff_T16A1.8 fbxb-37; T16A1.8; 2C376; CE13716; WBGene00020537; WP:CE13716 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated T17A3.4 Aff_T17A3.4 fbxb-82; T17A3.4; 3A756; CE19582; WBGene00020542; WP:CE19582 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Lund et al 2002 Fig3D Oocyte-en, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E T17A3.6 Aff_T17A3.6 fbxb-83; T17A3.6; 3A758; CE29343; WBGene00020543; WP:CE29343 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma T17A3.7 Aff_T17A3.7 fbxb-84; T17A3.7; 3A764; CE19584; NM_064756; WBGene00020544; WP:CE19584 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated T18D3.3 Aff_T18D3.3 T18D3.3; CE03664; WBGene00011821; WP:CE03664; XN84 cobalt uptake like protein McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 T19B10.1 Aff_T19B10.1 cyp-29A2; T19B10.1; 5L699; CE06455; NM_073446; WBGene00011830; WP:CE06455 cytochrome P450 Custodia et al 2001 T2 Cytochrome P450, McCarroll et al 2004 SFig5 conserved w/ yeast, Menzel et al 2001 T3 CYP genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T19C3.1 Aff_T19C3.1 T19C3.1; 3B226; CE30182; WBGene00020559; WP:CE30182 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C T19C3.5 Aff_T19C3.5 T19C3.5; 3B242; CE29347; WBGene00020563; WP:CE29347 T19C4.1 Aff_T19C4.1 T19C4.1; 5L629; CE06465; WBGene00011838; WP:CE06465 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T19H12.1 Aff_T19H12.1 ugt-9; T19H12.1; 5F375; CE13752; WBGene00020587; WP:CE13752 7TM chemoreceptor, ugt family Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, GO categories, Romagnolo et al 2002 Fig5 genes in let-60 timecour, Romagnolo et al 2002 Fig3b Detoxification, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T20B12.6 Aff_T20B12.6 mml-1; T20B12.6; 3I460; CE30186; CE32727; MYC; WBGene00003378; WP:CE30186; WP:CE32727; mio Jones et al 2001 Dauer specific genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit T20B3.1 Aff_T20B3.1 T20B3.1; 5R299; CE20086; WBGene00011850; WP:CE20086 Carnitate acyltransferase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B T20D4.15 Aff_T20D4.15 T20D4.15; 5D868; CE13806; WBGene00020620; WP:CE13806 T20D4.19 Aff_T20D4.19 T20D4.19; 5D900; CE13814; WBGene00020624; WP:CE13814 T20G5.4 Aff_T20G5.4 T20G5.4; 3L303; CE28844; WBGene00011868; WP:CE28844 Putative membrane protein T20G5.7 Aff_T20G5.7 dod-6; T20G5.7; 3L287; CE00587; NM_066856; WBGene00011869; WP:CE00587 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 daf-16 Resveratrol T21B6.1 Aff_T21B6.1 dgn-1; T21B6.1; T21B6.1.1; T21B6.1.2; CE03679; NM_077425; WBGene00000961; WP:CE03679; XL540 T21C12.2 Aff_T21C12.2 hpd-1; T21C12.2; 3L625; CE02347; NM_066923; WBGene00001993; WP:CE02347 hpd-1 encodes a 4-hydroxyphenylpyruvate dioxygenase that is required for normally short lifespan and negative regulation of the dauer larval stage, with loss of hpd-1 function prolonging lifespan and promoting dauer formation; hpd-1 is a (perhaps evolutionarily conserved) target of transcriptional activation by DAF-16; HPD-1 is orthologous to human HPD (OMIM:276710, mutated in tyrosinemia type III). 4-hydroxyphenylpyruvate dioxygenase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B T21H8.1 Aff_T21H8.1 CELIPRIN-BETA; T21H8.1; CE37412; WBGene00011904; WP:CE37412; XO484 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B T22A3.8 Aff_C43H8.3 lam-3; T22A3.8; 1L197; CE31067; NM_060374; WBGene00002248; WP:CE31067; lama1/2 lam-3 is orthologous to human LAMININ ALPHA-2 (LAMA2; OMIM:156225), which when mutated leads to merosin-deficient congenital muscular dystrophy. laminin B McCarroll et al 2004 SFig1-4 conserved w/ Drosoph T22B2.1 Aff_T22B2.1 T22B2.1; CE13928; WBGene00020665; WP:CE13928; XE545 ViswanathanM et al 2005 S2 sir-2.1 regulated T22B2.4 Aff_T22B2.4 sup-12; T22B2.4; CE13934; NM_076273; WBGene00006321; WBGene00020668; WP:CE13934; XE525 RNA-binding protein ViswanathanM et al 2005 S2 sir-2.1 regulated T22B7.3 Aff_T22B7.2, Aff_T22B7.3 T22B7.3; CE31242; WBGene00020672; WP:CE31242; XG273 Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, IVb male soma enriched genes, Romagnolo et al 2002 Fig3b Unkown T22D1.11 Aff_T22D1.11 T22D1.11; 4H692; CE17255; WBGene00020688; WP:CE17255 carboxyesterase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, herm soma enriched genes, Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T22E5.3 Aff_T22E5.3 T22E5.3; CE37152; WBGene00020691; WP:CE37152; XH5 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T22F7.5 Aff_T22F7.3 T22F7.5; 3B132; CE30305; WBGene00020704; WP:CE30305 T22H2.4 Aff_T22H2.4 T22H2.4; 1M288; CE14002; WBGene00011934; WP:CE14002 ViswanathanM et al 2005 S2 sir-2.1 regulated T22H2.6 Aff_T22H2.6 T22H2.6; 1M295; CE24004; CE24005; WBGene00011936; WP:CE24004; WP:CE24005 granulin precursor ViswanathanM et al 2005 S2 sir-2.1 regulated T22H6.2 Aff_T22H6.2 T22H6.2; T22H6.2a.1; T22H6.2a.2; CE03697; CE26824; WBGene00011938; WP:CE03697; WP:CE26824; XN405 1-pyroline-5-carboxylate synthetase ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T23C6.4 Aff_T23C6.4 T23C6.4; CE07529; WBGene00020726; WP:CE07529; XR762 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order T23D8.9 Aff_T23D8.9 sys-1; T23D8.9; 1K556; CE18959; CE27209; WBGene00006379; WBGene00011946; WP:CE18959; WP:CE27209 sys-1 encodes a novel protein that contains three divergent armadillo repeats; during gonadogenesis, SYS-1 functions in a Wnt/MAPK signaling pathway as a dosage-dependent beta-catenin-like transcriptional coactivator required for specification of distal cell fates; consistent with its role as a beta-catenin, SYS-1 interacts, in yeast two-hybrid and coimmunoprecipitation assays, with the POP-1/TCF transcription factor with which it can stimulate transcription via TCF binding sites; in two hybrid-assays, the POP-1/SYS-1 interaction requires the N-terminal beta-catenin binding domain of POP-1, and most of the SYS-1 protein; the SYS-1 expression pattern is not yet known. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T23G4.1 Aff_T23G4.1 tlp-1; T23G4.1; T23G4.1.1; T23G4.1.2; 4O466; CE16453; NM_070246; WBGene00006580; WP:CE16453 The tlp-1 gene encodes a C2H2-type zinc finger of the Sp-1-like protein family, which is required for normal asymmetry in the divisions of the T.p and T.ap cells; such asymmetry, in turn, is required for normal, rounded tail morphology in adult males. ViswanathanM et al 2005 S2 sir-2.1 regulated T23G5.6 Aff_T23G5.6 T23G5.6; 3K331; CE37794; WBGene00011964; WP:CE37794 ViswanathanM et al 2005 S2 sir-2.1 regulated T24A6.17 Aff_T24A6.17 T24A6.17; 5E42; WBGene00020754 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T24B8.6 Aff_T24B8.6 hlh-3; T24B8.6; 2J377; CE03714; NM_063537; WBGene00001950; WP:CE03714 hlh-3 encodes a basic helix-loop-helix transcription factor homologous to Drosophila Achaete-scute; in vitro, HLH-3 can heterodimerize, and bind an E-box-containing probe, with HLH-2, the C. elegans E/daughterless ortholog with which it is coexpressed in the nuclei of embryonic neuronal precursors. helix-loop-helix protein T24C12.3 Aff_T24C12.3 T24C12.3; CE31247; WBGene00020765; WP:CE31247; XC816 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, herm soma enriched genes T24C2.3 Aff_T24C2.3 T24C2.3; CE03717; WBGene00011982; WP:CE03717; XP161 ViswanathanM et al 2005 S2 sir-2.1 regulated T24C4.2 Aff_T24C4.2 T24C4.2; 3B482; CE19593; WBGene00020758; WP:CE19593 T24F1.3 Aff_T24F1.3 T24F1.3; T24F1.3b.1; T24F1.3b.2; T24F1.3b.3; 2L601; CE02363; CE38227; WBGene00011995; WP:CE02363; WP:CE38227 DAG binding domain Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order T25D10.4 Aff_T25D10.4 T25D10.4; 2G700; CE02061; WBGene00020801; WP:CE02061 ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination T25G12.8 Aff_T25G12.8 T25G12.8; CE07545; WBGene00020814; WP:CE07545; XR852 Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T26E3.5 Aff_T26E3.5 T26E3.5; 1N254; CE14192; WBGene00012038; WP:CE14192 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes T26E3.8 Aff_T26E3.8 T26E3.8; 1N250; CE21207; WBGene00012041; WP:CE21207 ViswanathanM et al 2005 S2 daf-16 Resveratrol T26H2.1 Aff_T26H2.1 fbxb-1; T26H2.1; 5T711; CE16487; WBGene00012063; WP:CE16487 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. T26H2.2 Aff_T26H2.2 fbxb-115; T26H2.2; 5T708; CE16488; WBGene00012064; WP:CE16488 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated T26H2.3 Aff_T26H2.3 fbxb-2; T26H2.3; 5T706; CE16489; WBGene00012065; WP:CE16489 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol T26H2.4 Aff_T26H2.4 fbxb-116; T26H2.4; 5T705; CE16490; WBGene00012066; WP:CE16490 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated T26H2.7 Aff_T26H2.7 T26H2.7; 5T697; CE16492; WBGene00012068; WP:CE16492 Romagnolo et al 2002 Fig3b signaling, ViswanathanM et al 2005 S2 daf-16 Resveratrol T26H2.9 Aff_T26H2.9 nhr-79; T26H2.9; 5T682; CE31072; NM_075333; WBGene00003669; WP:CE31072 Zinc finger, C4 type (two domains) T27A1.5 Aff_T27A1.5 T27A1.5; T27A1.5a.1; T27A1.5a.2; T27A1.5b.1; T27A1.5b.2; 2A815; CE14213; CE39784; WBGene00020837; WP:CE14213; WP:CE39784 McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T27A10.3 Aff_T27A10.3 ckc-1; T27A10.3; T27A10.3a.1; T27A10.3a.2; CE07553; CE33710; WBGene00000515; WP:CE07553; WP:CE33710; XE193 choline kinase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T27C4.4 Aff_T27C4.4 egr-1; T27C4.4; 5E189; CE21211; CE21212; CE33330; CE33331; NM_071630; NM_071631; NM_182323; NM_182324; WBGene00001219; WP:CE21211; WP:CE21212; WP:CE33330; WP:CE33331 egr-1 encodes a homolog of human MTA1, part of an ATP-dependent complex with nucleosome remodelling and histone deacetylation activities that may promote tumor metastasis; in conjunction with its paralog egl-27, egr-1 is required for proper organization in all parts of the embryo, and for the embryonic expression of hlh-8. Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma T27D12.1 Aff_T27D12.1 T27D12.1; T27D12.1.1; T27D12.1.2; T27D12.1.3; 2M135; CE06516; WBGene00012085; WP:CE06516 sodium/phosphate transporter Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol T27E4.1 Aff_T27E4.1 T27E4.1; 5J573; CE29357; WBGene00020861; WP:CE29357 Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated T27E4.8 Aff_T27E4.2 hsp-16.1; hsp-16; T27E4.8; 5J568; CE14249; NM_072953; WBGene00002015; WP:CE14249 hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein HSP16-1 Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated T27E4.9 Aff_T27E4.3 hsp-16.49; T27E4.9; 5J570; NM_072955; WBGene00002020 hsp-16.49 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.48; HSP-16.49 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein HSP16-48 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated T27E9.6 Aff_T27E9.6 T27E9.6; 3O564; CE34099; WBGene00012096; WP:CE34099 T28B4.3 Aff_T28B4.3 T28B4.3; CE14325; WBGene00020886; WP:CE14325; XH214 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, GO categories, Reinke et al 2004, fem3 enriched genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 T28F2.4 Aff_T28F2.4 T28F2.4; 1E200; CE28497; CE37050; WBGene00020902; WP:CE28497; WP:CE37050 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 T28F4.4 Aff_T28F4.4 T28F4.4; 1I62; CE06526; WBGene00012139; WP:CE06526 ViswanathanM et al 2005 S2 daf-16 Resveratrol T28H10.1 Aff_T28H10.1 T28H10.1; 5M985; CE06529; WBGene00012142; WP:CE06529 B.subtilis SFP protein like ViswanathanM et al 2005 S2 sir-2.1 regulated T28H10.3 Aff_T28H10.3 T28H10.3; 5M993; CE14367; WBGene00012144; WP:CE14367 vacuolar processing enzyme like Lund et al 2002 Fig4 Mount 15, ViswanathanM et al 2005 S2 daf-16 Resveratrol VF13D12L.1 Aff_VF13D12L.A VF13D12L.1; VF13D12L.1.1; VF13D12L.1.2; 2L990; CE31076; WBGene00012148; WP:CE31076 myo-inisitol-1-phosphate synthase McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated W01B6.1 Aff_W01B6.1 Wnt-2; cwn-2; W01B6.1; 4K833; CE03753; WBGene00000858; WP:CE03753 cwn-2 encodes a member of the WNT family; expressed at highest levels in embryos and expression declines and is almost absent by the third larval stage. WNT-2 precursor McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol W01C8.5 Aff_W01C8.5 W01C8.5; CE26751; WBGene00020921; WP:CE26751; XG314 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 W01G7.5 Aff_W01G7.5 lem-2; W01G7.5; 2O355; CE20129; NM_064543; WBGene00002275; WP:CE20129 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes W02B9.1 Aff_W02B9.1 hmr-1; W02B9.1; Y52B11B.2; 1L668; CE25133; CE30357; WBGene00001980; WP:CE25133; WP:CE30357 hmr-1 encodes two isoforms of a classical cadherin that contain extracellular cadherin, EGF-like, and laminin G domains as well as a highly conserved intracellular domain that binds beta-catenin; by homology, the HMR-1 proteins are predicted to function as calcium-dependent, homophilic cell-cell adhesion receptors; in vivo, HMR-1A activity is required for mediating the cell migrations, cell shape changes, and presumably actin cytoskeleton rearrangements that occur during embryonic morphogenesis; HMR-1B is required for fasciculation and outgrowth of a subset of motor neuron processes; HMR-1 antibodies detect expression in all embryonic blastomeres at early stages of development but as hypodermal adherens junctions form and morphogenesis begins, HMR-1 becomes highly expressed in the apical junctions of all hypodermal cells; later, HMR-1 is expressed primarily at the apical margins of hypodermal, pharyngeal, and intestinal cells in a pattern consistent with localization to adherens junctions; an HMR-1B reporter fusion is expressed in neurons, including the DD, VD, and AS class of motor neurons; HMR-1 activity is required for proper localization of other junctional components, such as HMP-1/alpha-catenin and HMP-2/beta-catenin, but not for localization of AJM-1, the junctional component recognized by the MH27 antibody. cadherin McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma W02D3.7 Aff_W02D3.7 lbp-5; W02D3.7; W02D3.7.1; W02D3.7.2; 1H308; CE14430; NM_059527; WBGene00002257; WP:CE14430 lbp-5 encodes a predicted intracellular fatty acid binding protein (iFABP) that is most similar to the vertebrate muscle and heart FABPs; by homology, LBP-5 is predicted to function as an intracellular transporter for small hydrophobic molecules such as lipids and steroid hormones; loss of lbp-5 activity via large-scale RNAi screens indicates that, in C. elegans, LBP-5 is required for movement. fatty acid-binding protein Jones et al 2001 Non dauer genes P<0.05, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated W02H5.8 Aff_W02H5_1932.C, Aff_W02H5_1932.J W02H5.8; W02H5.A; W02H5_1932.A; 5D126; CE21240; WBGene00020962; WP:CE21240 McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 W03A3.1 Aff_W03A3.1 ceh-10; mig-11; W03A3.1; 3G889; CE07563; NM_065850; WBGene00000435; WP:CE07563 ceh-10 encodes a member of the Paired-like class of homeodomain proteins; the CEH-10 homeodomain is closely related to the homeodomains of two vertebrate retina proteins (Chx10 from mice and Vsx-1 from goldfish); ceh-10 is required for CAN cell fate specification and migration, complete loss of ceh-10 function results in failure of CAN cell migration and loss of expression of CEH-23 and CEH-10 itself in the CAN and AIY interneurons; CEH-10, along with TTX-3 and CEH-23, constitutes a regulatory cascade of transcription factors that controls all sub-type specific features of the AIY interneurons. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 daf-16 Resveratrol W03C9.6 Aff_W03C9.6 W03C9.6; W03C9.6.1; W03C9.6.2; 2M251; CE32948; WBGene00012222; WP:CE32948 W03D2.1 Aff_W03D2.1 pqn-75; W03D2.1; 4E841; CE14506; CE28501; CE31729; NM_171311; NM_171312; NM_171903; WBGene00004157; WP:CE14506; WP:CE28501; WP:CE31729 The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). W04A8.3 Aff_W04A8.3 W04A8.3; 1O436; CE16537; WBGene00012238; WP:CE16537 W04A8.4 Aff_W04A8.4 W04A8.4; 1O434; CE16538; WBGene00012239; WP:CE16538 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order W04A8.5 Aff_W04A8.5 W04A8.5; 1O442; CE16539; WBGene00012240; WP:CE16539 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated W04D2.1 Aff_W04D2.1 atn-1; W04D2.1; 5M963; CE06539; CE21256; NM_073726; NM_073727; WBGene00000228; WP:CE06539; WP:CE21256 atn-1 encodes an alpha-actinin homolog. W04G3.8 Aff_W04G3.8 W04G3.8; W04G3.8.1; W04G3.8.2; CE19004; WBGene00012261; WP:CE19004; XL677 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Reinke et al 2004, IVb male soma enriched genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 LateList, Wang et al 2003 S4 genes pass two-wayANOVA P0 W05E10.3 Aff_W05E10.3 ceh-32; W05E10.3; W05E10.3.1; W05E10.3.2; 5M182; CE29364; NM_073557; WBGene00000453; WP:CE29364 ceh-32 encodes a Six/sine oculis-type homeodomain protein most closely related to the Six3/6 subfamily that contains Drosophila OPTIX and human SIX3 (OMIM:603714, which when mutated leads to holoprosencephaly 2); CEH-32 appears to be essential for development and required for proper head morphogenesis; during embryogenesis, CEH-32 is expressed in hypodermal and neuronal precursors, and at later stages, in the descendants of these cells and in gonadal sheath cells; in some hypodermal cells, ceh-32 is a direct transcriptional target of VAB-3, a PAX-6 ortholog sufficient to induce ceh-32 expression in some cell types and able to bind the ceh-32 promoter in vitro. homeobox protein (so subfamily) McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol W05H12.2 Aff_W05H12.2 W05H12.2; 1O0; CE14660; WBGene00012290; WP:CE14660 ViswanathanM et al 2005 S2 sir-2.1 regulated W05H7.4 Aff_W05H7.4 W05H7.4; CE33719; CE35046; CE35047; CE38431; CE38432; WBGene00021047; WP:CE33719; WP:CE35046; WP:CE35047; WP:CE38431; WP:CE38432; XC60 ViswanathanM et al 2005 S2 sir-2.1 regulated W05H9.1 Aff_W05H9.1 W05H9.1; W05H9.1.1; W05H9.1.2; CE05036; WBGene00021048; WP:CE05036; XG891 Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Zhang et al 2002, T1 mec-3 dependent genes, Zhang et al. 2002, Fig2b overexpressed in mec-3MT W05H9.3 Aff_W05H9.3 W05H9.3; W05H9.3.1; W05H9.3.2; CE05038; WBGene00021050; WP:CE05038; XG873 Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated W06D4.5 Aff_T06D10.C tag-157; W06D4.5; 1J640; CE16547; WBGene00006503; WP:CE16547 PhoX homologous domain, present in p47phox and p40phox. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated W06E11.2 Aff_W06E11.2 W06E11.2; 3B259; CE01427; WBGene00021062; WP:CE01427 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated W06H12.1 Aff_Y53H1A.A ztf-6; W06H12.1; W06H12.1.1; W06H12.1.2; 1L803; CE25145; WBGene00012317; WP:CE25145 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 W06H8.1 Aff_W06H8.E rme-1; W06H8.1; W06H8.1f.1; W06H8.1f.2; W06H8.1f.3; 5G697; CE25146; CE25147; CE25148; CE30204; CE31086; CE33335; WBGene00004373; WP:CE25146; WP:CE25147; WP:CE25148; WP:CE30204; WP:CE31086; WP:CE33335 The rme-1 gene encodes a C. elegans protein required for endocytosis. W08G11.3 Aff_W08G11.3 W08G11.3; 5Q849; CE39423; CE39424; WBGene00012347; WP:CE39423; WP:CE39424 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol W09D6.4 Aff_W09D6.4 W09D6.4; 3M169; CE19018; WBGene00012357; WP:CE19018 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 sir-2.1 regulated W09G12.1 Aff_W09G12.1 dsl-2; W09G12.1; 4B956; CE23182; NM_067651; WBGene00001104; WP:CE23182 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, list of genes in cluster E W09G12.4 Aff_W09G12.4 dsl-1; W09G12.4; 4B960; CE18343; NM_067653; WBGene00001103; WP:CE18343 W10C8.2 Aff_W03D8.4, Aff_W10C8.2 pop-1; sys-2; W10C8.2; 1D392; CE26031; NM_058652; WBGene00004077; WP:CE26031 pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E W10G6.2 Aff_W10G6.2 sgk-1; tag-74; W10G6.2; W10G6.2a.1; W10G6.2a.2; CE39527; CE39528; NM_078246; WBGene00004789; WP:CE39527; WP:CE39528; XQ870 Protein kinase C terminal domain McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B Y102A5C.12 Aff_Y102A5C.10 Y102A5C.12; 5R422; CE20384; WBGene00013618; WP:CE20384 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y105C5A.14 Aff_Y105C5.N Y105C5A.14; 4Q408; CE39802; WBGene00013638; WP:CE39802 ViswanathanM et al 2005 S2 sir-2.1 regulated Y105C5B.13 Aff_Y105C5.KK, Aff_Y105C5.LL skr-10; Y105C5B.13; 4Q711; CE24062; NM_070501; WBGene00004816; WP:CE24062 skr-10 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-10 is required for posterior body morphogenesis, embryonic and larval development, and cell proliferation; SKR-10 is expressed in the tip and end regions of the intestine and can interact in vivo with CUL-1 and CUL-2, C. elegans cullin homologs. Y105C5B.9 Aff_Y105C5.FF Y105C5B.9; 4Q695; CE24085; WBGene00013650; WP:CE24085 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y106G6D.1 Aff_Y106G6D.1 Y106G6D.1; 1K682; CE19299; WBGene00013698; WP:CE19299 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y106G6D.2 Aff_Y106G6D.2 Y106G6D.2; 1K687; CE19300; WBGene00013699; WP:CE19300 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated Y106G6H.4 Aff_Y106G6H.4 Y106G6H.4; 1L14; CE20414; WBGene00013717; WP:CE20414 Y106G6H.9 Aff_Y106G6H.9 Y106G6H.9; 1L30; CE20419; WBGene00013721; WP:CE20419 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Murphy et al 2003 Fig2 Class2 shorten lifespan Y110A2AL.4 Aff_Y110A2A_54.H Y110A2AL.4; 2D131; CE33472; CE33473; WBGene00022441; WP:CE33472; WP:CE33473 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y111B2A.1 Aff_Y111B2A.A Y111B2A.1; 3N580; CE34107; WBGene00013727; WP:CE34107 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y113G7B.8 Aff_Y113G7B.F fbxb-59; Y113G7B.8; 5U674; CE23290; WBGene00013759; WP:CE23290 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y116A8B.1 Aff_Y116A8B.1 Y116A8B.1; 4S161; CE16679; WBGene00013779; WP:CE16679 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated Y116A8C.19 Aff_Y116A8A.G Y116A8A.G; Y116A8C.19; 4R982; CE23328; WBGene00013796; WP:CE23328 ViswanathanM et al 2005 S2 daf-16 Resveratrol Y116A8C.20 Aff_Y116A8A.F Y116A8A.F; Y116A8C.20; 4R985; CE23329; WBGene00013797; WP:CE23329 ViswanathanM et al 2005 S2 sir-2.1 regulated Y119D3B.17 Aff_Y119D3_447.A pes-4; Y119D3B.17; 3C306; CE32746; NM_064950; WBGene00003978; WP:CE32746 pes-4 encodes a protein that contains two type 1 KH domains, RNA-binding domains that are present in a diverse group of nucleic acid-binding proteins; pes-4 was identified in promoter-trapping screens and by homology, is predicted to function as an RNA-binding protein; however, the precise role of PES-4 in C. elegans development and/or behavior is not yet known; a pes-4 reporter is expressed in three rectal epithelial cells from the L1 larval stage through adulthood and is also seen dispersed throughout the pharynx in all postembryonic stages. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y18D10A.5 Aff_Y18D10A.F gsk-3; sgg-1; Y18D10A.5; Y18D10A.F; 1N417; CE21401; NM_060842; WBGene00001746; WP:CE21401 Eukaryotic protein kinase domain McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y22D7AL.14 Aff_Y119D3_465.U Y22D7AL.14; 3C742; CE23435; WBGene00021252; WP:CE23435 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y23H5A.1 Aff_Y23H5A.1 crs-2; Y23H5A.1; 1D199; CE31095; CE32959; NM_170831; NM_170832; WBGene00000801; WP:CE31095; WP:CE32959 crs-2 encodes a predicted cysteinyl-tRNA synthetase required for fertility. Y25C1A.6 Aff_Y25C1A.I Y25C1A.6; Y25C1A.6.1; Y25C1A.6.2; Y25C1A.I; CE21473; WBGene00021293; WP:CE21473 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, ViswanathanM et al 2005 S2 sir-2.1 regulated Y32H12A.5 Aff_Y32H12A_57.D Y32H12A.5; Y32H12A.5.1; Y32H12A.5.2; 3G466; CE35070; WBGene00021313; WP:CE35070 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y34D9A.4 Aff_Y34D9A_151.A spd-1; Y34D9A.4; 1B504; CE37061; NM_058408; WBGene00004952; WBGene00021330; WP:CE37061 spd-1 encodes a homolog of human PRC1, tobacco MAP-65, and S. cerevisiae Ase1p that is required for embryonic viability due to its requirement for mitotic spindle stability during the late stages of cytokinesis; SPD-1 is also required for fertility, gonad development, locomotion, and vulval development. Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, Fig2b shared gemlines, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y37A1B.5 Aff_Y37A1B.5 Y37A1B.5; 4O819; CE19075; WBGene00012538; WP:CE19075 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination Y37D8A.17 Aff_Y37D8A.17 Y37D8A.17; 3O12; CE20221; WBGene00012555; WP:CE20221 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y37E11B.1 Aff_Y37E11B.1 Y37E11B.1; 4E345; CE33856; CE34609; WBGene00021374; WP:CE33856; WP:CE34609 zinc finger protein Y37E11B.5 Aff_Y37E11B.5 Y37E11B.5; 4E360; CE19615; WBGene00021377; WP:CE19615 This gene encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial. McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y38F2AL.1 Aff_Y38F2A_5743.J Y38F2AL.1; 4D91; CE39822; WBGene00021415; WP:CE39822 Y38F2AL.1 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; Y38F2AL.1 is worm-specific, with obvious homologs only in C. elegans; Y38F2AL.1 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y38H6C.10 Aff_Y38H6C.10 Y38H6C.10; 5U988; CE19104; WBGene00012623; WP:CE19104 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Y38H6C.11 Aff_Y38H6C.11 Y38H6C.11; 5U995; CE19105; WBGene00012624; WP:CE19105 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction. Lund et al 2002 Fig1 aging-regulated genes Y38H6C.16 Aff_Y38H6C.16 Y38H6C.16; 5V6; CE19110; WBGene00012628; WP:CE19110 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y38H6C.7 Aff_Y38H6C.7 Y38H6C.7; 5U985; CE19101; WBGene00012620; WP:CE19101 GuhaThakurta et al 2002 T1 upregu on heat stress Y39A1A.16 Aff_Y39A1A.16 Y39A1A.16; 3L769; CE19136; WBGene00012654; WP:CE19136 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated Y39A3CL.5 Aff_Y39A3C_85.A clp-4; Y39A3CL.5; Y39A3CL.5b.1; Y39A3CL.5b.2; 3C898; CE33219; CE33220; NM_065059; NM_181914; WBGene00000545; WP:CE33219; WP:CE33220 clp-4 encodes a large calpain subunit that is homologous to Drosophila CalpainB and the mammalian muscle-specific Calpain 3 proteins (OMIM:114240, mutations are associated with limb-girdle muscular dystrophy); by homology, CLP-4 is predicted to function as a nonlysosomal, calcium-dependent, cysteine protease that is involved in intracellular proteolysis and peptidolysis; however, as loss of clp-4 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of CLP-4 in C. elegans development and/or behavior is not yet known. Y39B6A.11 Aff_Y39B6.V Y39B6A.11; Y39B6B.V; 5T605; CE21697; WBGene00012673; WP:CE21697 Y39B6A.6 Aff_B0413.A tsp-13; Y39B6A.6; 5T631; CE21670; NM_171602; WBGene00006639; WP:CE21670 Y39G10AR.10 Aff_Y39G10A_246.A Y39G10AR.10; Y39G10AR.10.1; Y39G10AR.10.2; 1C869; CE26989; WBGene00021468; WP:CE26989 Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y39G10AR.18 Aff_Y74C10A_151.B Y39G10AR.18; 1C952; CE36735; CE38003; WBGene00021474; WP:CE36735; WP:CE38003 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y40B10B.2 Aff_Y40B10B.A srj-15; Y40B10B.2; Y40B10B.A; 5C440; CE21799; NM_071138; WBGene00005603; WP:CE21799 7TM chemoreceptor, srj family ViswanathanM et al 2005 S2 sir-2.1 regulated Y40B1B.3 Aff_Y40B1B.3 fbxb-66; tag-228; Y40B1B.3; 1O14; CE20237; WBGene00012737; WBGene00044066; WP:CE20237 Y41D4A.4 Aff_Y41D4A_5905.B Y41D4A.4; Y41D4A.4.1; Y41D4A.4.2; 4C515; CE21847; WBGene00021506; WP:CE21847 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y41D4B.26 Aff_Y41D4B_930.A nhr-146; Y41D4B.26; 4C397; CE36740; WBGene00021525; WP:CE36740 Y43F11A.1 Aff_Y43F11.A Y43F11A.1; 2M402; CE21916; WBGene00012841; WP:CE21916 Y43F8C.13 Aff_Y116F11.ZZ9 Y43F8C.13; 5U164; CE21911; WBGene00012834; WP:CE21911 Inosine-uridine preferring nucleoside hydrolase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes Y44A6C.2 Aff_Y44A6C.2 Y44A6C.2; 5V193; CE18389; WBGene00012851; WP:CE18389 Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order Y45F10D.10 Aff_Y45F10D.10 Y45F10D.10; 4O550; CE16648; WBGene00012889; WP:CE16648 Jones et al 2001 Dauer specific genes P<0.05, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S7 SAGE genes in the dataset, Wang et al 2003 S8 SAGE genes in the dauer exit Y45G12C.3 Aff_Y45G12C.L Y45G12C.3; Y45G12C.E; 5D31; WBGene00021566 Custodia et al 2001 T2 Glut-S-transferase, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y46E12A.4 Aff_Y119D3_463.A Y46H3A.1 Aff_Y32G9B_366.D srt-42; Y46H3A.1; 5C285; CE35804; CE38004; WBGene00021599; WP:CE35804; WP:CE38004 7TM chemoreceptor, srt family ViswanathanM et al 2005 S2 sir-2.1 regulated Y46H3A.2 Aff_Y46H3A.E hsp-16.41; HSP16-41; Y46H3A.2; Y46H3A.E; 5C283; CE22003; NM_071107; WBGene00002018; WP:CE22003 hsp-16.41 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; an hsp-16.41 reporter fusion, expressed broadly but strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.41 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein Golden et al 2004, N2 differentially expressed gen, Link et al 2003 T3 Abeta highly induced, Link et al 2003 T2 Abeta induced, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated Y46H3A.3 Aff_Y46H3A.D hsp-16.2; Y46H3A.3; Y46H3A.D; 5C282; CE22002; NM_071106; WBGene00002016; WP:CE22002 hsp-16.2 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; hsp-16.2 expression, strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; HSP-16.2 has been shown to interact with intracellular human beta amyloid peptide, a primary component of the extracellular plaques found in Alzheimer's disease; HSP-16.2 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. heat shock protein Golden et al 2004, N2 differentially expressed gen, Golden et al 2004, daf-2 differentially expressed , Link et al 2003 T3 Abeta highly induced, Link et al 2003 T2 Abeta induced, Murphy et al 2003 Fig2 Class1 elongate lifespan, Romagnolo et al 2002 Fig2a heat shock, ViswanathanM et al 2005 S2 sir-2.1 regulated Y46H3C.6 Aff_Y46H3C_14.B Y46H3C.6; 5C176; CE35806; WBGene00021606; WP:CE35806 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated Y47D3A.15 Aff_Y47D3A.Q aakb-2; Y47D3A.15; 3M327; CE22044; WBGene00012928; WP:CE22044 McCarroll et al 2004 SFig5 conserved w/ yeast Y47H9B.2 Aff_Y47H9B.1 Y47H9B.2; 1M339; CE34123; WBGene00012946; WP:CE34123 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y48A6B.9 Aff_Y48A6B.9 Y48A6B.9; Y48A6B.9.1; Y48A6B.9.2; 3M125; CE19192; WBGene00012970; WP:CE19192 Zinc-binding dehydrogenases Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y48E1A.1 Aff_Y48E1A.1 Y48E1A.1; 2N962; CE22157; CE37860; WBGene00012999; WP:CE22157; WP:CE37860 DNA-directed RNA polymerase I largest subunit McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y48E1B.10 Aff_Y48E1B.10 gst-20; Y48E1B.10; 2N898; CE14870; NM_064457; WBGene00001768; WP:CE14870 glutathione S-transferase ReichertK et al 2005 T1 xenobiotic induced GSTs, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S6 removed genes of contamination Y48G1C.6 Aff_Y48G1B_55.E Y48G1C.6; 1A558; CE22175; WBGene00021679; WP:CE22175 ViswanathanM et al 2005 S2 sir-2.1 regulated Y49F6B.1 Aff_Y49F6B_108.I cyh-1; Y49F6B.1; Y49F6B.R; 2D797; CE36037; NM_062163; WBGene00021714; WP:CE36037 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y49F6B.2 Aff_Y49F6B_108.H Y49F6B.2; 2D793; CE25336; WBGene00021715; WP:CE25336 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y49F6B.5 Aff_Y49F6B_110.F sdz-32; Y49F6B.5; 2D765; CE25339; WBGene00021717; WP:CE25339 Y50D4B.2 Aff_Y50D4B_10.A Y50D4B.2; 5B579; CE24401; WBGene00021741; WP:CE24401 Y50E8A.11 Aff_Y50E8A.Q Y50E8A.11; 5P263; CE22318; WBGene00013054; WP:CE22318 Y51A2D.17 Aff_Y51A2D.17 nhr-70; Y51A2D.17; 5T99; CE22324; NM_075235; WBGene00003660; WP:CE22324 Zinc finger, C4 type (two domains) ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y51B9A.3 Aff_Y51B9A.3 Y51B9A.3; 2J696; CE19213; WBGene00013085; WP:CE19213 Reinke et al 2004, male sperm, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, mixed sperm soma, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, fem3 enriched genes Y51H7BR.2 Aff_Y51H7B_6.B fbxb-43; Y51H7BR.2; 2B827; CE22356; WBGene00021774; WP:CE22356 Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes Y53C10A.5 Aff_Y53C10A.B Y53C10A.5; 1M593; CE22373; WBGene00013136; WP:CE22373 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, ViswanathanM et al 2005 S2 sir-2.1 regulated Y53F4B.14 Aff_Y53F4B.Q Y53F4B.14; 2P325; CE25395; WBGene00013161; WP:CE25395 Y53G8AM.7 Aff_Y53G8A_2706.B Y53G8AM.7; 3E350; CE25413; WBGene00021807; WP:CE25413 ViswanathanM et al 2005 S2 daf-16 Resveratrol Y53G8B.1 Aff_Y53G8B_9248.A Y53G8B.1; 3E219; CE25427; WBGene00021817; WP:CE25427 Murphy et al 2003 Fig2 Class1 elongate lifespan Y54E10A.15 Aff_Y54E10A_156.A cdt-1; Y54E10A.15; 1D792; CE22447; NM_058725; NM_182086; WBGene00000413; WP:CE22447 Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, herm soma enriched genes Y54E2A.12 Aff_Y54E2A.12 Y54E2A.12; 2P85; CE37068; WBGene00013196; WP:CE37068 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated Y54E5A.1 Aff_Y105E8A.AA Y54E5A.1; 1P280; CE28791; WBGene00013197; WP:CE28791 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C Y54G11B.1 Aff_Y54G11B.1 Y54G11B.1; 2O747; CE16663; WBGene00013222; WP:CE16663 Jones et al 2001 Non dauer genes P<0.05 Y55B1AR.1 Aff_Y55B1A_120.D lec-6; Y55B1AR.1; Y55B1AR.1.1; Y55B1AR.1.2; 3B218; CE22493; NM_064814; WBGene00002269; WP:CE22493 lec-6 encodes a 'proto' type galectin (beta-galactosyl-binding lectin) containing a single carbohydrate recognition domain; by homology, LEC-6 may play roles in cell adhesion and aggregation, proliferation, or programmed cell death, but as loss of lec-6 activity via large-scale RNAi screens does not result in obvious abnormalities, the precise role of LEC-6 in C. elegans development and/or behavior is not yet known; in vitro, LEC-6 can interact with several types of blood group precursor oligosaccharides and gangliosides. Reinke et al 2004, intrinsic, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, IVb male soma enriched genes Y55B1BR.3 Aff_Y55B1B_119.B Y55B1BR.3; 3B49; CE24463; WBGene00021913; WP:CE24463 Reinke et al 2004, list of genes in cluster order Y55D5A.1 Aff_Y55D5A_392.F Y55D5A.1; 3E77; CE27294; CE34131; WBGene00021915; WP:CE27294; WP:CE34131 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y55D5A.6 Aff_Y55D5A_391.A Y55D5A.6; 3E132; CE22512; WBGene00021919; WP:CE22512 Golden et al 2004, N2 vs daf-2 different genes at Y55F3AM.15 Aff_Y55F3A_739.A csn-4; Y55F3AM.15; 4B832; CE25482; NM_067633; WBGene00000816; WP:CE25482 csn-4 encodes a protein with similarity to human COP9 proteasome subunit 4. Jones et al 2001 Non dauer genes P<0.05, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y55F3AR.2 Aff_Y55F3A_750.E Y55F3AR.2; Y55F3A_750.E; 4B849; CE34418; WBGene00021933; WP:CE34418 Y55F3BR.8 Aff_Y55F3A_747.E Y55F3BR.8; 4B602; CE31657; CE37730; WBGene00021945; WP:CE31657; WP:CE37730 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, list of genes in cluster order, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated Y56A3A.15 Aff_Y56A3A.M fbxb-24; Y56A3A.15; Y56A3A.G; 3M999; CE22582; WBGene00013234; WP:CE22582 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. Murphy et al 2003 Fig2 Class2 shorten lifespan, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57A10A.19 Aff_Y57A10A.S Y57A10A.19; 2M517; CE25503; WBGene00013260; WP:CE25503 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, intrinsic, Reinke et al 2004, list of genes in cluster F, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order Y57A10A.23 Aff_Y57A10A.W Y57A10A.23; Y57A10A.23.1; Y57A10A.23.2; 2M531; CE22626; WBGene00013263; WP:CE22626 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S5 genes common to feeding ANOVA, Wang et al 2003 S3 genes pass one-way ANOVA Y57A10C.1 Aff_Y57A10C.1 Y57A10C.1; 2M702; CE22632; WBGene00013280; WP:CE22632 Y57A10C.6 Aff_Y57A10C.6 P-44; Y57A10C.6; 2M714; CE18418; WBGene00013284; WP:CE18418 3-keto-acyl-CoA thiolase McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57G11C.8 Aff_Y57G11C.8 Y57G11C.8; 4P547; CE39974; WBGene00013306; WP:CE39974 Reinke et al 2004, herm sperm, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated Y57G7A.2 Aff_Y57G7A.2 Y57G7A.2; 2B587; CE19631; WBGene00021966; WP:CE19631 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y58G8A.4 Aff_Y58G8A_208.A Y58G8A.4; 5A756; CE33345; CE36962; WBGene00021983; WP:CE33345; WP:CE36962 Y60A3A.1 Aff_Y60A3.W unc-51; Y60A3.W; Y60A3A.1; Y60A3A.1.1; Y60A3A.1.2; 5U466; CE24516; NM_075468; WBGene00006786; WP:CE24516 The unc-51 gene encodes an activity required for both axonogenesis and sex myoblast migration. serine/threonine protein kinase McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y60A9.3 Aff_Y60A9.A Y60A9.3; Y60A9B.A; CE22669; WBGene00013370; WP:CE22669; XO997 ViswanathanM et al 2005 S2 sir-2.1 regulated Y61A9LA.3 Aff_Y61A9LA_71.B Y61A9LA.3; 5F63; CE27412; CE31122; CE36964; WBGene00022015; WP:CE27412; WP:CE31122; WP:CE36964 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y63D3A.2 Aff_Y63D3A.2 fbxb-100; Y63D3A.2; 1O684; CE20333; WBGene00013403; WP:CE20333 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins. ViswanathanM et al 2005 S2 sir-2.1 regulated Y63D3A.3 Aff_Y63D3A.3 fbxb-101; Y63D3A.3; 1O681; CE25528; WBGene00013404; WP:CE25528 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y63D3A.8 Aff_Y63D3A.8 Y63D3A.8; 1O709; CE39301; WBGene00013407; WP:CE39301 Y69A2AR.29 Aff_Y69A2A_7278.I ngn-1; Y69A2AR.29; 4D392; CE26560; NM_067835; WBGene00003595; WP:CE26560 ngn-1 encodes a member of the neurogenein family that is required for axonal guidance and connectivity of a subset of neurons, and also affects locomotion. Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated Y69H2.6 Aff_Y69H2.I ubc-19; Y69H2.6; Y69H2.I; 5T168; CE22824; NM_075246; WBGene00006714; WP:CE22824 ubc-19 encodes a predicted conjgating enzyme (UBCs/E2s) of the ubiquitin-conjugation system with a potentially low effect on embryonic viability, based on RNAi analysis. ViswanathanM et al 2005 S2 daf-16 Resveratrol Y69H2.9 Aff_Y69H2.L Y69H2.9; 5T183; CE22827; WBGene00013484; WP:CE22827 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order Y70D2A.2 Aff_Y70D2.A Y70D2.A; Y70D2A.2; CE34134; WBGene00013497; WP:CE34134; XP520 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y71A12B.3 Aff_Y71A12B.M Y71A12B.3; 1O485; WBGene00013501 Y71D11A.3 Aff_Y71D11A.C Y71D11A.3; 3C231; ACMSD; CE25548; CE32030; WBGene00022104; WP:CE25548; WP:CE32030 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster B, Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S4 Early genes, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 Y71F9AL.6 Aff_Y71F9A_262.B Y71F9AL.6; 1D459; CE22840; WBGene00022111; WP:CE22840 Y71F9AL.7 Aff_Y71F9A_294.G Y71F9AL.7; 1D457; CE22861; WBGene00022112; WP:CE22861 ViswanathanM et al 2005 S2 sir-2.1 regulated Y71F9B.5 Aff_Y71F9B_299.B lin-17; Y71F9B.5; Y71F9B.5b.1; Y71F9B.5b.2; Y71F9B_287.C; 1D285; CE25569; CE28810; NM_058627; WBGene00003006; WP:CE25569; WP:CE28810 lin-17 encodes one of four C. elegans Frizzled homologs, integral membrane proteins that contain an external cysteine rich domain (CRD) and seven transmembrane domains and that function in a wide variety of species as receptors for Wnt glycoprotein signaling molecules; LIN-17 activity is required for specifying the polarity of a number of asymmetric cell divisions that, in C. elegans, are essential for development of such structures as the vulva, somatic gonad, and tail; LIN-17 is also required for the proper polarity of neuronal migrations along the anterior-posterior axis; genetic interactions indicate that LIN-17 likely functions as a receptor for several different Wnt molecules, including LIN-44 and EGL-20, and that in specifying cell fates, the LIN-17-mediated signaling pathway often functions redundantly with other signaling pathways, including the RTK/Ras pathway; a LIN-17 translational reporter fusion shows membrane-associated expression in all of the Pn.pxx vulval precursor cells, in the descendants of V6 and T in males, in the P11.p and B cells, as well as their daughters, and granddaughters, and weakly in P10.p and its daughters; the reporter fusion does not reveal expression in P7.p, Z1, Z4, and T Reinke et al 2004, wt herm vs wt herm enriched gen, ViswanathanM et al 2005 S2 sir-2.1 regulated Y71F9B.8 Aff_Y71F9B_297.C Y71F9B.8; 1D304; CE25571; WBGene00022129; WP:CE25571 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y71G12B.11 Aff_Y71G12A_195.A Y71G12B.11; 1C213; CE27024; CE29914; WBGene00022151; WP:CE27024; WP:CE29914 Romagnolo et al 2002 Fig3b Unkown, ViswanathanM et al 2005 S2 sir-2.1 regulated Y71H2AM.13 Aff_Y71H2_390.F Y71H2AM.13; 3D824; CE22953; WBGene00022178; WP:CE22953 Y71H2AM.17 Aff_Y71H2_375.B, Aff_Y71H2_390.A Y71H2AM.17; 3D854; CE39070; WBGene00022182; WP:CE39070 McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, oogenesis enriched genes, Reinke et al 2004, wt herm vs wt male enriched gen, Reinke et al 2004, list of genes in cluster E, ViswanathanM et al 2005 S2 sir-2.1 regulated Y73C8C.3 Aff_Y73C8C.3 Y73C8C.3; 5D597; CE20359; WBGene00022262; WP:CE20359 Y73F8A.16 Aff_Y73F8A.O tbx-39; Y73F8A.16; 4Q89; CE22985; NM_070450; WBGene00006558; WP:CE22985 Y73F8A.17 Aff_Y73F8A.P tbx-40; Y73F8A.17; 4Q90; CE22986; NM_070451; WBGene00006559; WP:CE22986 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y75B12A.2 Aff_Y75B12A.2 Y75B12A.2; 5P591; CE19269; WBGene00013566; WP:CE19269 ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol Y75B8A.13 Aff_Y75B8A.Q Y75B8A.13; Y75B8A.Q; 3N294; CE23025; WBGene00013549; WP:CE23025 ViswanathanM et al 2005 S2 sir-2.1 regulated Y75B8A.2 Aff_Y75B8A.C nob-1; Y75B8A.2; Y75B8A.C; 3N168; CE29009; CE29010; WBGene00003779; WP:CE29009; WP:CE29010 The nob-1 gene encodes one of three C. elegans posterior group homeodomain transcription factors orthologous to Drosophila Abd-B and the vertebrate Hox9-13 proteins; NOB-1, along with an additional posterior Hox ortholog, PHP-3, is required during embryogenesis for proper fate specification and morphogenesis of cells in the posterior region. Baugh et al 2005, validated PAL-1 target genes, Baugh et al 2005, PAL-1 target genes Y75B8A.26 Aff_Y75B8A.FF mrp-8; Y75B8A.26; 3N372; CE23037; NM_067197; WBGene00003414; WP:CE23037 mrp-8 encodes a predicted ATP-binding cassette (ABC) transporter that is a member of the ABCC subfamily of ABC transporters that includes the multidrug resistance-associated proteins and the cystic fibrosis transmembrane conductance regulator; by homology, MRP-8 is predicted to function as an ATP-dependent organic anion transporter that transports molecules across the plasma membrane into the extracellular space; at present, the precise role of MRP-8 in C. elegans development and/or behavior is not yet known. ABC transporters ; ABC transporter transmembrane region. Y75B8A.29 Aff_Y75B8A.LL Y75B8A.29; 3N421; CE23040; WBGene00013560; WP:CE23040 Y75B8A.4 Aff_Y75B8A.E Y75B8A.4; Y75B8A.4.1; Y75B8A.4.2; 3N201; CE23016; WBGene00013541; WP:CE23016 ATPases associated with various cellular activities (AAA) ViswanathanM et al 2005 S2 sir-2.1 regulated Y76A2B.3 Aff_Y76A2B.3 Y76A2B.3; 3O630; CE19275; WBGene00013575; WP:CE19275 AMP-binding enzyme Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C Y76B12C.8 Aff_Y76B12C_67.D Y76B12C.8; Y76B12C.8.1; Y76B12C.8.2; 4C743; CE23063; WBGene00022302; WP:CE23063 Y7A9D.1 Aff_Y7A9D.1 Y7A9D.1; 4R146; CE14850; WBGene00012420; WP:CE14850 Reinke et al 2004, IVb male soma enriched genes Y82E9BL.2 Aff_Y119D3_465.D Y82E9BL.2; 3C442; CE23418; WBGene00022319; WP:CE23418 Y82E9BL.3 Aff_Y119D3_465.E Y82E9BL.3; 3C440; CE23419; WBGene00022320; WP:CE23419 ViswanathanM et al 2005 S2 daf-16 Resveratrol Y82E9BL.5 Aff_Y119D3_465.F Y82E9BL.5; 3C436; CE27547; WBGene00022322; WP:CE27547 Y82E9BR.1 Aff_Y119D3_465.J Y82E9BR.1; 3C557; CE27035; WBGene00022334; WP:CE27035 ViswanathanM et al 2005 S2 daf-16 Resveratrol Y82E9BR.17 Aff_Y119D3_448.B Y82E9BR.17; 3C536; CE27337; CE34434; WBGene00022349; WP:CE27337; WP:CE34434 Y82E9BR.20 Aff_Y119D3_444.A Y82E9BR.20; 3C465; CE29934; WBGene00022352; WP:CE29934 Y94H6A.9 Aff_Y94H6A_132.B ubxn-2; Y94H6A.9; Y94H6A_132.B; 4D486; CE27555; CE33955; WBGene00022381; WP:CE27555; WP:CE33955 McCarroll et al 2004 SFig5 conserved w/ yeast, McCarroll et al 2004 SFig1-4 conserved w/ Drosoph Y9C9A.13 Aff_Y9C9A_54.B Y9C9A.13; 4F722; CE25647; WBGene00021180; WP:CE25647 ViswanathanM et al 2005 S2 sir-2.1 regulated ZC204.3 Aff_ZC204.3 ZC204.3; 2B945; CE36349; WBGene00022555; WP:CE36349 ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S6 removed genes of contamination ZC204.7 Aff_ZC204.7 fbxb-15; ZC204.7; 2B942; CE29615; WBGene00022557; WP:CE29615 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, mixed oogenesis soma ZC204.9 Aff_ZC204.9 fbxb-20; ZC204.9; 2B938; CE15100; WBGene00022559; WP:CE15100 This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. ViswanathanM et al 2005 S2 sir-2.1 regulated ZC376.1 Aff_ZC376.1 ZC376.1; 5O656; CE15193; WBGene00013873; WP:CE15193 carboxylesterase ZC376.3 Aff_ZC376.3 ZC376.3; 5O650; CE15197; WBGene00013875; WP:CE15197 carboxylesterase Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, Reinke et al 2004, list of genes in cluster B, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZC412.6 Aff_ZC412.6 nspa-5; ZC412.6; 5P359; CE15221; NM_074263; WBGene00013887; WP:CE15221 McElwee et al 2003 T1 targets of daf-16, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, shared sperm ZC412.7 Aff_ZC412.7 nspa-3; ZC412.7; 5P362; NM_074265; WBGene00013888 McElwee et al 2003 T1 targets of daf-16, Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated ZC455.5 Aff_ZC455.5 ugt-4; ZC455.5; 5N274; CE06594; WBGene00013905; WP:CE06594 UDP-glucuronysltransferase ViswanathanM et al 2005 S2 sir-2.1 regulated, ViswanathanM et al 2005 S2 daf-16 Resveratrol, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZC8.3 Aff_ZC8.2 tag-226; ZC8.3; CE33744; WBGene00022499; WP:CE33744; XF621 ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK1058.6 Aff_ZK1058.6 nit-1; ZK1058.6; 3F11; CE01106; WBGene00014206; WP:CE01106 Nitrilase McCarroll et al 2004 SFig5 conserved w/ yeast, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1193.5 Aff_ZK1193.5 ZK1193.5; CE33746; CE33747; CE33748; WBGene00022861; WP:CE33746; WP:CE33747; WP:CE33748; XB46 ZK1193.5 encodes, by alternative splicing, three proteins with a COMPASS (CMP) domain and two homeodomains; the CMP domain is found in the N-terminus of SATB-class CUT homeodomain proteins (e.g. human SATB1), and in Drosophila DEFECTIVE PROVENTRICULUS (DVE), to which ZK1193.5 may be orthologous; both DVE and ZK1193.5 encode two homeodomains which are highly divergent, but homologous between species, and probably derived by intragenic duplication; ZK1193.5 is required for a normally high rate of growth, fluid excretion, and larval viability in in mass RNAi assays. McCarroll et al 2004 SFig1-4 conserved w/ Drosoph, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK1251.6 Aff_ZK1251.6 msp-76; ZK1251.6; 4K453; NM_069321; WBGene00003463 msp-76 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein (MSP1) Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK1320.10 Aff_ZK1320.10 nlp-11; ZK1320.10; ZK1320.10.1; ZK1320.10.2; 2J978; CE01699; NM_063690; WBGene00003749; WP:CE01699 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 Dauer Enriched, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK177.2 Aff_ZK177.2 ZK177.2; 2F807; CE02091; WBGene00022670; WP:CE02091 Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK185.1 Aff_ZK185.1 ZK185.1; 4F315; CE17310; WBGene00022681; WP:CE17310 ZK185.2 Aff_ZK185.2 ZK185.2; 4F305; CE31747; WBGene00022682; WP:CE31747 ZK228.3 Aff_ZK228.3 ZK228.3; 5S940; CE24719; WBGene00013946; WP:CE24719 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK270.1 Aff_ZK270.1 ptr-23; ZK270.1; 1P503; CE15305; NM_061202; WBGene00004237; WP:CE15305 Baugh et al 2005, PAL-1 target genes, Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order ZK287.8 Aff_ZK287.8 her-1; ZK287.8; 5K181; CE06617; CE37304; WBGene00001842; WP:CE06617; WP:CE37304 The autosomal gene her-1 is repressed by SDC-2 to elicit hermaphrodite differentiation; SDC-2 also represses transcription of X chromosomes to achieve dosage compensation. Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, IVb male soma enriched genes ZK328.8 Aff_ZK328.6 tbx-7; ZK328.8; 3H114; CE29639; NM_065912; WBGene00006544; WP:CE29639 tbx-7 encodes one of 21 C. elegans T-box transcription factors; in large-scale RNAi screens for early embryonic defects, loss of tbx-7 activity results in no obvious abnormalities; thus, the precise role of tbx-7 in C. elegans development and/or behavior is not yet known. ZK354.1 Aff_ZK354.1 msp-65; ZK354.1; 4G81; NM_068379; WBGene00003458 msp-65 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. major sperm protein (MSP-65) Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, list of genes in cluster D, Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 daf-16 Resveratrol, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK380.1 Aff_Y75D11B_91.A, Aff_ZK380.1 tbx-32; ZK380.1; CE26339; NM_075903; WBGene00006551; WP:CE26339; XC271 DNA-binding protein ZK430.5 Aff_ZK430.5 ZK430.5; 2E703; CE05081; WBGene00022741; WP:CE05081 Reinke et al 2004, fem1 enriched genes, Reinke et al 2004, mixed oogenesis soma, Reinke et al 2004, GO categories ZK512.3 Aff_ZK512.3 ced-11; ZK512.3; 3K213; CE00409; NM_066620; WBGene00000425; WP:CE00409 The ced-11 gene encodes a predicted transmembrane ion channel related to the long transient receptor potential channel (LTRPC) subfamily of TRP channels found in Drosophila and mammals; CED-11 functions as a downstream effector in the programmed cell death pathway and may play a role in affecting the morphological changes seen in the nucleus, cytoplasm, and plasma membrane of apoptotic cells. Wang et al 2003 S4 TransientList, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK525.2 Aff_ZK525.2 aqp-11; ZK525.2; 3O765; CE33909; NM_067420; WBGene00000179; WP:CE33909 Reinke et al 2004, list of genes in cluster order, Reinke et al 2004, list of genes in cluster C, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK546.4 Aff_ZK546.4 ZK546.4; 2F229; CE02918; WBGene00022761; WP:CE02918 ZK550.6 Aff_ZK550.6 ZK550.6; ZK550.6.1; ZK550.6.2; 4S204; CE20432; WBGene00014000; WP:CE20432 The ZK550.6 gene encodes an ortholog of the human gene PHYTANOYL-COA HYDROXYLASE (PHYH; PAHX; OMIM:602026), which when mutated leads to Refsum disease (OMIM:266500). Murphy et al 2003 Fig2 Class1 elongate lifespan, Reinke et al 2004, mixed sperm soma, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, IVb male soma enriched genes ZK593.1 Aff_ZK593.1 ZK593.1; 4L677; CE24731; WBGene00014001; WP:CE24731 pyruvate kinase McCarroll et al 2004 SFig5 conserved w/ yeast, Reinke et al 2004, GO categories, Reinke et al 2004, herm soma enriched genes, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK622.3 Aff_ZK622.3 phi-40; ZK622.3; ZK622.3a.1; ZK622.3a.2; ZK622.3a.3; ZK622.3c.1; ZK622.3c.10; ZK622.3c.11; ZK622.3c.2; ZK622.3c.3; ZK622.3c.4; ZK622.3c.5; ZK622.3c.6; ZK622.3c.7; ZK622.3c.8; ZK622.3c.9; ZK622.3d.1; ZK622.3d.2; ZK622.3d.3; ZK622.3d.4; ZK622.3d.5; ZK622.3d.6; ZK622.3d.7; ZK622.3d.8; 2F570; CE29162; CE32290; CE33504; CE33505; WBGene00022781; WP:CE29162; WP:CE32290; WP:CE33504; WP:CE33505 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order, ViswanathanM et al 2005 S2 sir-2.1 regulated, Wang et al 2003 S4 Climbing, Wang et al 2003 S3 genes pass one-way ANOVA, Wang et al 2003 S4 genes pass two-wayANOVA P0 ZK637.4 Aff_ZK637.4 ZK637.4; 3J983; CE00435; WBGene00014024; WP:CE00435 ZK673.5 Aff_ZK673.5 ZK673.5; 2K751; CE02394; WBGene00014061; WP:CE02394 ViswanathanM et al 2005 S2 sir-2.1 regulated ZK75.2 Aff_ZK75.2 ins-2; ZK75.2; 2G277; CE02101; NM_062793; WBGene00002085; WP:CE02101 7TM chemoreceptor, ins family Lund et al 2002 Fig1 aging-regulated genes, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK792.7 Aff_ZK792.7 ZK792.7; 4M461; CE03828; WBGene00014079; WP:CE03828 Yeast CC1 like McCarroll et al 2004 SFig1-4 conserved w/ Drosoph ZK809.7 Aff_ZK809.7 prx-2; ZK809.7; 4M411; CE03835; NM_069800; WBGene00004192; WP:CE03835 prx-2 is orthologous to the human gene PEROXISOMAL MEMBRANE PROTEIN 3 (PXMP3; OMIM:170993), which when mutated leads to Zellweger syndrome 3 or infantile Refsum disease. Zinc finger, C3HC4 type (RING finger) Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order ZK896.9 Aff_ZK896.9 ZK896.9; 4N619; CE15465; WBGene00014139; WP:CE15465 CMP-sialic acid transporter McCarroll et al 2004 SFig1-4 conserved w/ Drosoph ZK899.6 Aff_ZK899.6 ZK899.6; CE01123; WBGene00014144; WP:CE01123; XK81 ZK909.5 Aff_ZK909.5 fbxb-70; ZK909.5; 1P546; CE15481; WBGene00014149; WP:CE15481 ViswanathanM et al 2005 S2 daf-16 Resveratrol ZK930.3 Aff_ZK930.3 ZK930.3; 2M188; CE37306; CE37948; WBGene00014153; WP:CE37306; WP:CE37948 Reinke et al 2004, list of genes in cluster A, Reinke et al 2004, list of genes in cluster order ZK930.6 Aff_ZK930.6 ZK930.6; 2M173; CE06676; WBGene00014156; WP:CE06676 Lund et al 2002 Fig1 aging-regulated genes, Reinke et al 2004, spermatogenesis enriched genes, Reinke et al 2004, wt herm vs wt herm enriched gen, Reinke et al 2004, fem3 enriched genes, Reinke et al 2004, wt vs glp-4 enriched genes, Reinke et al 2004, wt males vs glp4 male enriched , Reinke et al 2004, shared sperm, ViswanathanM et al 2005 S2 sir-2.1 regulated ZK938.2 Aff_ZK938.2 ZK938.2; 2K128; CE02397; WBGene00014159; WP:CE02397 ViswanathanM et al 2005 S2 daf-16 Resveratrol